1ilh A 2.76 BS01 SRL A 1 M243 M246 S247 F251 F281 C284 Q285 F288 W299 M82 M85 S86 F90 F120 C123 Q124 F127 W138 ? 0003677,0004879,0006355 -logKd/Ki=7.39, Kd=41nM EC50=440nM O75469 11408620 1 GLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGI 1nrl A 2.0 BS02 SRL A 1 M243 A244 S247 Q285 Y306 M323 H407 L411 F429 M88 A89 S92 Q130 Y151 M168 H252 L256 F274 ? 0003677,0004879,0006355 EC50=440nM O75469 12909012 1 GLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITG 1nrl B 2.0 BS02 SRL B 1 L209 M243 S247 Q285 W299 Y306 M323 H327 H407 L411 F420 F429 L53 M87 S91 Q129 W143 Y150 M167 H171 H251 L255 F264 F273 ? 0003677,0004879,0006355 EC50=440nM O75469 12909012 2 GLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGI 3hvl A 2.1 BS01 SRL A 1 M243 S247 F281 Q285 F288 W299 Y306 H407 L411 F429 M89 S93 F127 Q131 F134 W145 Y152 H247 L251 F269 2.3.1.48 0003677,0004879,0006355 O75469,Q15788 18456871 1 GLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITSLTERHKILHRLLQE 3hvl B 2.1 BS01 SRL B 1 M243 S247 F281 Q285 W299 Y306 M323 H327 H407 L411 F420 F429 M91 S95 F129 Q133 W147 Y154 M164 H168 H248 L252 F261 F270 2.3.1.48 0003677,0004879,0006355 O75469,Q15788 18456871 2 VQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGISLTERHKILHRLLQEGS 4j5x A 2.8 BS01 SRL A 1 L209 M243 M246 S247 Q285 F288 W299 Y306 M323 H407 M425 L55 M89 M92 S93 Q131 F134 W145 Y152 M169 H253 M271 2.3.1.48 0003677,0004879,0006355 O75469,Q15788 23602807 501 QGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITSLTERHKILHRLLQE 4j5x B 2.8 BS01 SRL B 1 L209 V211 M243 S247 Q285 F288 W299 Y306 M323 H327 H407 M425 L57 V59 M91 S95 Q133 F136 W147 Y154 M167 H171 H251 M269 2.3.1.48 0003677,0004879,0006355 O75469,Q15788 23602807 501 GVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGISSLTERHKILHRLLQEGS