5x8i A 1.902 BS01 SQZ A 1 L167 G168 F172 V175 A189 K191 F241 L244 N293 L295 D325 L14 G15 F19 V22 A36 K38 F88 L91 N140 L142 D172 D288 K290 N293 D325 T342 D135 K137 N140 D172 T189 2.7.12.1 0004672,0005524,0006468 ic50=2nM IC50=2.0nM P49759 28692292 501 GDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLK 5x8i B 1.902 BS01 SQZ B 1 L167 G168 F172 V175 A189 K191 F241 L244 N293 L295 D325 L13 G14 F18 V21 A35 K37 F87 L90 N139 L141 D171 D288 K290 N293 D325 T342 D134 K136 N139 D171 T188 2.7.12.1 0004672,0005524,0006468 ic50=2nM -logKd/Ki=8.70, IC50=2nM IC50=2.0nM P49759 28692292 501 DVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLK