3ow3 A 1.9 BS02 SMY A 1 L49 G50 T51 V57 A70 K72 M120 Y122 V123 E127 L173 T183 D184 F327 L35 G36 T37 V43 A56 K58 M106 Y108 V109 E113 L159 T169 D170 F313 D166 K168 E170 N171 D184 T201 D152 K154 E156 N157 D170 T187 2.7.11.11 0000122,0000287,0001669,0001707,0001843,0004672,0004674,0004679,0004691,0004712,0005515,0005524,0005634,0005654,0005737,0005739,0005813,0005829,0005886,0005930,0005952,0006397,0006468,0006611,0007189,0007193,0016310,0016607,0018105,0019901,0019904,0030145,0031410,0031514,0031594,0031625,0032024,0034237,0034605,0036126,0044853,0045542,0045667,0045722,0045879,0046827,0048240,0048471,0050804,0051726,0061136,0070417,0070613,0071333,0071374,0071377,0097546,0098794,0098978,0099170,0106310,0141156,1904262,1904539,1990044,2000810 ic50=742nM -logKd/Ki=6.13, IC50=742nM P05132 20971641 401 VKEFLAKAKEDFLKKWETPSQNTAQLDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFTEF 3ow4 A 2.6 BS02 SMY A 1 L156 G162 K163 V164 A230 E234 M281 T291 F438 L13 G19 K20 V21 A87 E91 M138 T148 F295 D274 K276 N279 D292 T312 D131 K133 N136 D149 T169 2.7.11.1 0004672,0004674,0005524,0006468 -logKd/Ki=7.66, IC50=22nM IC50=22nM P31749 20971641 1 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITRPHFPQFDYSASS 3ow4 B 2.6 BS02 SMY B 1 L156 G157 K158 G162 A177 K179 A230 E234 M281 T291 F438 L13 G14 K15 G19 A34 K36 A87 E91 M138 T148 F295 D274 K276 N279 D292 T312 D131 K133 N136 D149 T169 2.7.11.1 0004672,0004674,0005524,0006468 IC50=22nM P31749 20971641 2 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITRPHFPQFDYSASS