1u8a A 2.15 BS02 SKM A 1 D34 F49 R58 G80 G81 L119 R136 D33 F48 R57 G79 G80 L116 R133 2.7.1.71 0000287,0004765,0005524,0005737,0005829,0008652,0009073,0009423,0016301,0016310,0019632,0019752,0046872 P9WPY3 15358538 181 APKAVLVGLPGSGKSTIGRRLAKALGVGLLDTDVAIEQRTGRSIADIFATDGEQEFRRIEEDVVRAALADHDGVLSLGGGAVTSPGVRAALAGHTVVYLEISAAEGVRRTGGVRPLLAGPDRAEKYRALMAKRAPLYRRVATMRVDTNRRNPGAVVRHILSRL 1zui A 2.3 BS01 SKM A 1 M10 D33 F48 R57 G79 G80 E114 R116 R132 M9 D32 F47 R56 G78 G79 E111 R113 R129 2.7.1.71 0000287,0004765,0005524,0005737,0005829,0008652,0009073,0009423,0016301,0016310,0019752,0046872 P56073 16291688 2001 QHLVLIGFMGSGKSSLAQELGLALKLEVLDTDMIISERVGLSVREIFEELGEDNFRMFEKNLIDELKTLKTPHVISTGGGIVMHENLKGLGTTFYLKMDFETLIKRLNQREKRPLLNNLTQAKELFEKRQALYEKNASFIIDARGGLNNSLKQVLQFI 1zyu A 2.9 BS02 SKM A 1 D34 R58 G81 P118 L119 R136 D33 R57 G80 P117 L118 R135 2.7.1.71 0000287,0004765,0005524,0005737,0005829,0008652,0009073,0009423,0016301,0016310,0019632,0019752,0046872 P9WPY3 16834327 401 APKAVLVGLPGSGKSTIGRRLAKALGVGLLDTDVAIEQRTGRSIADIFATDGEQEFRRIEEDVVRAALADHDGVLSLGGGAVTSPGVRAALAGHTVVYLEISAAEGVRRTGGNTVRPLLAGPDRAEKYRALMAKRAPLYRRVATMRVDTNRRNPGAVVRHILSRLQVP 2aa9 A 1.5 BS01 SKM A 1 K22 S23 R27 T97 Q171 Y200 D313 K340 K22 S23 R27 T97 Q171 Y200 D313 K340 K22 S23 D49 N94 P119 R124 D313 E341 H385 R386 K411 K22 S23 D49 N94 P119 R124 D313 E341 H385 R386 K411 2.5.1.19 0003824,0003866,0005737,0005829,0008652,0009073,0009423,0016740,0016765 -logKd/Ki=2.92, IC50=1.2mM IC50=>90000000nM P0A6D3 16225867 501 MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTALGVSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPRMKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTAPLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVEGDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTRGELNAIDMDMNHIPDAAMTIATAALFAKGTTTLRNIYNWRVKETDRLFAMATELRKVGAEVEEGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILDPKCTAKTFPDYFEQLARISQAA 2aay A 1.55 BS01 SKM A 1 K22 S23 R27 T97 Q171 Y200 D313 K340 K22 S23 R27 T97 Q171 Y200 D313 K340 K22 S23 D49 N94 P119 R124 D313 E341 H385 R386 K411 K22 S23 D49 N94 P119 R124 D313 E341 H385 R386 K411 2.5.1.19 0003824,0003866,0005737,0005829,0008652,0009073,0009423,0016740,0016765 ic50=1.2mM -logKd/Ki=2.92, IC50=1.2mM IC50=>90000000nM P0A6D3 16225867 701 MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTALGVSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPRMKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTAPLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVEGDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTRGELNAIDMDMNHIPDAAMTIATAALFAKGTTTLRNIYNWRVKETDRLFAMATELRKVGAEVEEGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILDPKCTAKTFPDYFEQLARISQAA 2d5c A 1.65 BS01 SKM A 1 S14 S16 N58 K64 N85 D100 Q235 S14 S16 N58 K64 N85 D100 Q235 K64 D100 K64 D100 1.1.1.25 0004764,0005829,0008652,0009073,0009423,0016491,0019632,0050661 Q5SJF8 17825835 301 MLRFAVLGHPVAHSLSPAMHAFALESLGLEGSYEAWDTPLEALPGRLKEVRRAFRGVNLTLPLKEAALAHLDWVSPEAQRIGAVNTVLQVEGRLFGFNTDAPGFLEALKAGGIPLKGPALVLGAGGAGRAVAFALREAGLEVWVWNRTPQRALALAEEFGLRAVPLEKAREARLLVNATRVGLEDPSASPLPAELFPEEGAAVDLVYRPLWTRFLREAKAKGLKVQTGLPMLAWQGALAFRLWTGLLPDPSGMEEAARRAL 2d5c B 1.65 BS01 SKM B 1 S14 S16 N58 K64 N85 D100 L232 Q235 S14 S16 N58 K64 N85 D100 L228 Q231 K64 D100 K64 D100 1.1.1.25 0004764,0005829,0008652,0009073,0009423,0016491,0019632,0050661 Q5SJF8 17825835 302 MLRFAVLGHPVAHSLSPAMHAFALESLGLEGSYEAWDTPLEALPGRLKEVRRAFRGVNLTLPLKEAALAHLDWVSPEAQRIGAVNTVLQVEGRLFGFNTDAPGFLEALKAGGIPLKGPALVLGAGGAGRAVAFALREAGLEVWVWNRTPQRALALAEEFGLRAVPLEKAREARLLVNATRVGLASPLPAELFPEEGAAVDLVYRPLWTRFLREAKAKGLKVQTGLPMLAWQGALAFRLWTGLLPDPSGMEEAARRALGV 2dfn A 1.93 BS03 SKM A 1 D34 I45 F57 R58 G79 G80 G81 R136 D33 I44 F56 R57 G78 G79 G80 R135 2.7.1.71 0000287,0004765,0005524,0005737,0005829,0008652,0009073,0009423,0016301,0016310,0019632,0019752,0046872 P9WPY3 17183161 500 APKAVLVGLPGSGKSTIGRRLAKALGVGLLDTDVAIEQRTGRSIADIFATDGEQEFRRIEEDVVRAALADHDGVLSLGGGAVTSPGVRAALAGHTVVYLEISAAEGVRRTGGNTVRPLLAGPDRAEKYRALMAKRAPLYRRVATMRVDTNRRNPGAVVRHILSRL 2ev9 A 1.9 BS01 SKM A 1 S14 S16 N58 K64 N85 D100 Q235 S14 S16 N58 K64 N85 D100 Q235 K64 D100 K64 D100 1.1.1.25 0004764,0005829,0008652,0009073,0009423,0016491,0019632,0050661 Q5SJF8 17825835 301 MLRFAVLGHPVAHSLSPAMHAFALESLGLEGSYEAWDTPLEALPGRLKEVRRAFRGVNLTLPLKEAALAHLDWVSPEAQRIGAVNTVLQVEGRLFGFNTDAPGFLEALKAGGIPLKGPALVLGAGGAGRAVAFALREAGLEVWVWNRTPQRALALAEEFGLRAVPLEKAREARLLVNATRVGLEDPSASPLPAELFPEEGAAVDLVYRPLWTRFLREAKAKGLKVQTGLPMLAWQGALAFRLWTGLLPDPSGMEEAARRAL 2ev9 B 1.9 BS01 SKM B 1 S14 S16 N58 T60 K64 N85 D100 Q235 S14 S16 N58 T60 K64 N85 D100 Q235 K64 D100 K64 D100 1.1.1.25 0004764,0005829,0008652,0009073,0009423,0016491,0019632,0050661 Q5SJF8 17825835 302 MLRFAVLGHPVAHSLSPAMHAFALESLGLEGSYEAWDTPLEALPGRLKEVRRAFRGVNLTLPLKEAALAHLDWVSPEAQRIGAVNTVLQVEGRLFGFNTDAPGFLEALKAGGIPLKGPALVLGAGGAGRAVAFALREAGLEVWVWNRTPQRALALAEEFGLRAVPLEKAREARLLVNATRVGLEDPSASPLPAELFPEEGAAVDLVYRPLWTRFLREAKAKGLKVQTGLPMLAWQGALAFRLWTGLLPDPSGMEEAARRALGV 2g1k A 1.75 BS01 SKM A 1 D34 R58 G80 G81 R136 D33 R57 G79 G80 R135 2.7.1.71 0000287,0004765,0005524,0005737,0005829,0008652,0009073,0009423,0016301,0016310,0019632,0019752,0046872 P9WPY3 16834327 401 APKAVLVGLPGSGKSTIGRRLAKALGVGLLDTDVAIEQRTGRSIADIFATDGEQEFRRIEEDVVRAALADHDGVLSLGGGAVTSPGVRAALAGHTVVYLEISAAEGVRRTGGNTVRPLLAGPDRAEKYRALMAKRAPLYRRVATMRVDTNRRNPGAVVRHILSRLQVP 2gpt A 1.95 BS01 SKM A 1 I328 S336 S338 T381 K385 N406 D423 Y550 Q578 Q582 I239 S247 S249 T292 K296 N317 D334 Y436 Q464 Q468 E159 H214 K241 E70 H125 K152 1.1.1.25,4.2.1.10 0003855,0004764,0019632,0050661 Q9SQT8 16784230 4733 VKNPSLICAPVMADSIDKMVIETSKAHELGADLVEIRLDWLKDFNPLEDLKTIIKKSPLPTLFTYRPKWEGGQYEGDENERRDVLRLAMELGADYIDVELQVASEFIKSIDGKKPGKFKVIVSSHNYQNTPSVEDLDGLVARIQQTGADIVKIATTAVDIADVARMFHITSKAQVPTIGLVMGERGLMSRILCSKFGGYLTFGTLDSSKVSAPGQPTIKDLLDLYNFRRIGPDTKVYGIIGKPVSHSKSPIVHNQAFKSVDFNGVYVHLLVDNLVSFLQAYSSSDFAGFSCTIPHKEAALQCCDEVDPLAKSIGAVNTILRRKSDGKLLGYNTDCIGSISAIEDGLTVVVIGAGGAGKALAYGAKEKGAKVVIANRTYERELAEAIGALSLTDLDNYEDGMVLANTTSMGMQPNVEETPISKDALKHYALVFDAVYTPRITRLLREAEESGAITVSGSEMFVRQAYEQFEIFTGLPAPKELYWQIMSKYGSRENLYFQ 2hk9 A 2.2 BS02 SKM A 1 S19 S21 N64 K70 N91 D106 Y216 L239 Q242 S19 S21 N64 K70 N91 D106 Y216 L239 Q242 1.1.1.25 0004764,0005829,0008652,0009073,0009423,0016491,0019632,0050661 O67049 17649975 1102 MINAQTQLYGVIGFPVKHSLSPVFQNALIRYAGLNAVYLAFEINPEELKKAFEGFKALKVKGINVTVPFKEEIIPLLDYVEDTAKEIGAVNTVKFENGKAYGYNTDWIGFLKSLKSLIPEVKEKSILVLGAGGASRAVIYALVKEGAKVFLWNRTKEKAIKLAQKFPLEVVNSPEEVIDKVQVIVNTTSVGLKDEDPEIFNYDLIKKDHVVVDIIYKETKLLKKAKEKGAKLLDGLPMLLWQGIEAFKIWNGCEVPYSVAERSVRDLRG 2hk9 B 2.2 BS02 SKM B 1 S19 S21 N64 T66 K70 N91 D106 Y216 L239 Q242 S19 S21 N64 T66 K70 N91 D106 Y216 L239 Q242 1.1.1.25 0004764,0005829,0008652,0009073,0009423,0016491,0019632,0050661 O67049 17649975 1202 MINAQTQLYGVIGFPVKHSLSPVFQNALIRYAGLNAVYLAFEINPEELKKAFEGFKALKVKGINVTVPFKEEIIPLLDYVEDTAKEIGAVNTVKFENGKAYGYNTDWIGFLKSLKSLIPEVKEKSILVLGAGGASRAVIYALVKEGAKVFLWNRTKEKAIKLAQKFPLEVVNSPEEVIDKVQVIVNTTSVGLKDEDPEIFNYDLIKKDHVVVDIIYKETKLLKKAKEKGAKLLDGLPMLLWQGIEAFKIWNGCEVPYSVAERSVRDL 2hk9 C 2.2 BS02 SKM C 1 S19 S21 N64 T66 K70 D106 Y216 L239 Q242 S19 S21 N64 T66 K70 D106 Y216 L239 Q242 1.1.1.25 0004764,0005829,0008652,0009073,0009423,0016491,0019632,0050661 O67049 17649975 1302 MINAQTQLYGVIGFPVKHSLSPVFQNALIRYAGLNAVYLAFEINPEELKKAFEGFKALKVKGINVTVPFKEEIIPLLDYVEDTAKEIGAVNTVKFENGKAYGYNTDWIGFLKSLKSLIPEVKEKSILVLGAGGASRAVIYALVKEGAKVFLWNRTKEKAIKLAQKFPLEVVNSPEEVIDKVQVIVNTTSVGLKDEDPEIFNYDLIKKDHVVVDIIYKETKLLKKAKEKGAKLLDGLPMLLWQGIEAFKIWNGCEVPYSVAERSVRD 2hk9 D 2.2 BS02 SKM D 1 S19 S21 N64 T66 K70 N91 D106 Y216 L239 Q242 S19 S21 N64 T66 K70 N91 D106 Y216 L239 Q242 1.1.1.25 0004764,0005829,0008652,0009073,0009423,0016491,0019632,0050661 O67049 17649975 1402 MINAQTQLYGVIGFPVKHSLSPVFQNALIRYAGLNAVYLAFEINPEELKKAFEGFKALKVKGINVTVPFKEEIIPLLDYVEDTAKEIGAVNTVKFENGKAYGYNTDWIGFLKSLKSLIPEVKEKSILVLGAGGASRAVIYALVKEGAKVFLWNRTKEKAIKLAQKFPLEVVNSPEEVIDKVQVIVNTTSVGLKDEDPEIFNYDLIKKDHVVVDIIYKETKLLKKAKEKGAKLLDGLPMLLWQGIEAFKIWNGCEVPYSVAERSVRD 2iyq A 1.8 BS01 SKM A 1 D34 I45 R58 G79 G80 G81 R136 D33 I44 R57 G78 G79 G80 R135 2.7.1.71 0000287,0004765,0005524,0005737,0005829,0008652,0009073,0009423,0016301,0016310,0019632,0019752,0046872 P9WPY3 17020768 201 APKAVLVGLPGSGKSTIGRRLAKALGVGLLDTDVAIEQRTGRSIADIFATDGEQEFRRIEEDVVRAALADHDGVLSLGGGAVTSPGVRAALAGHTVVYLEISAAEGVRRTGGNTVRPLLAGPDRAEKYRALMAKRAPLYRRVATMRVDTNRRNPGAVVRHILSRLQ 2iyr A 1.98 BS01 SKM A 1 D34 I45 R58 G79 R136 D33 I44 R57 G78 R130 2.7.1.71 0000287,0004765,0005524,0005737,0005829,0008652,0009073,0009423,0016301,0016310,0019632,0019752,0046872 P9WPY3 17020768 201 APKAVLVGLPGSGKSTIGRRLAKALGVGLLDTDVAIEQRTGRSIADIFATDGEQEFRRIEEDVVRAALADHDGVLSLGGGAVTSPGVRAALAGHTVVYLEISAAEGVRRTGGNTAGPDRAEKYRALMAKRAPLYRRVATMRVDTNRRNPGAVVRHILSRLQVPS 2iyr B 1.98 BS01 SKM B 1 D34 F49 R58 G80 G81 L119 R136 D33 F48 R57 G79 G80 L116 R133 2.7.1.71 0000287,0004765,0005524,0005737,0005829,0008652,0009073,0009423,0016301,0016310,0019632,0019752,0046872 P9WPY3 17020768 201 APKAVLVGLPGSGKSTIGRRLAKALGVGLLDTDVAIEQRTGRSIADIFATDGEQEFRRIEEDVVRAALADHDGVLSLGGGAVTSPGVRAALAGHTVVYLEISAAEGVRRTGGNTVLLAGPDRAEKYRALMAKRAPLYRRVATMRVDTNRRNPGAVVRHILSRLQVPS 2iys A 1.4 BS01 SKM A 1 D34 G80 G81 D33 G79 G80 2.7.1.71 0000287,0004765,0005524,0005737,0005829,0008652,0009073,0009423,0016301,0016310,0019632,0019752,0046872 P9WPY3 17020768 201 APKAVLVGLPGSGKSTIGRRLAKALGVGLLDTDVAIEQRTGRSIADIFATDGEQEFRRIEEDVVRAALADHDGVLSLGGGAVTSPGVRAALAGHTVVYLEISAAEGVRRTGGNTVRPLLAGPDRAEKYRALMAKRAPLYRRVATMRVDTNRRNPGAVVRHILSRLQVPSPSEAAT 2iyx A 1.49 BS01 SKM A 1 D34 R58 G81 R136 D33 R57 G80 R135 2.7.1.71 0000287,0004765,0005524,0005737,0005829,0008652,0009073,0009423,0016301,0016310,0019632,0019752,0046872 P9WPY3 17020768 201 APKAVLVGLPGSGKSTIGRRLAKALGVGLLDTDVAIEQRTGRSIADIFATDGEQEFRRIEEDVVRAALADHDGVLSLGGGAVTSPGVRAALAGHTVVYLEISAAEGVRRTGGNTVRPLLAGPDRAEKYRALMAKRAPLYRRVATMRVDTNRRNPGAVVRHILSRLQVPS 3baf A 2.25 BS02 SKM A 1 D34 R136 D33 R135 2.7.1.71 0000287,0004765,0005524,0005737,0005829,0008652,0009073,0009423,0016301,0016310,0019632,0019752,0046872 P9WPY3 500 APKAVLVGLPGSGKSTIGRRLAKALGVGLLDTDVAIEQRTGRSIADIFATDGEQEFRRIEEDVVRAALADHDGVLSLGGGAVTSPGVRAALAGHTVVYLEISAAEGVRRTGGNTVRPLLAGPDRAEKYRALMAKRAPLYRRVATMRVDTNRRNPGAVVRHILSRL 3doo A 2.2 BS01 SKM A 1 S13 S15 N58 T60 K64 N85 D100 F236 Q239 S13 S15 N58 T60 K64 N85 D100 F227 Q230 1.1.1.25 0004764,0005829,0008652,0009073,0009423,0016491,0019632,0050661 Q5HNV1 19215302 300 MKFAVIGNPISHSLSPLMHHANFQSLNLENTYEAINVPVNQFQDIKKIISEKSIDGFNVTIPHKERIIPYLDDINEQAKSVGAVNTVLVKDGKWIGYNTDGIGYVNGLKQIYEGIEDAYILILGAGGASKGIANELYKIVRPTLTVANRTMSRFNNWSLNINKINLSHAESHLDEFDIIINTTPVISLNRLASHTLVSDIVYNPYKTPILIEAEQRGNPIYNGLDMFVHQGAESFKIWTNLEPDIKAMKNIVIQKLKG 3jyq A 1.16 BS02 SKM A 1 S17 N67 T69 N94 D110 Q258 S16 N66 T68 N93 D109 Q257 1.1.1.-,1.1.1.24 0004764,0005829,0008652,0009073,0009423,0016491,0019632,0030266,0050661,0052734,0070403 Q9X5C9 23929881 378 NDSILLGLIGQGLDLSRTPAMHEAEGLAQGRATVYRRIDTLGSRASGQDLKTLLDAALYLGFNGLNITHPYKQAVLPLLDEVSEQATQLGAVNTVVIDATGHTTGHNTDVSGFGRGMEEGLPNAKLDSVVQVGAGGVGNAVAYALVTHGVQKLQVADLDTSRAQALADVINNAVGREAVVGVDARGIEDVIAAADGVVNATPMGMPAHPGTAFDVSCLTKDHWVGDVVYMPIETELLKAARALGCETLDGTRMAIHQAVDAFRLFTGLEPDVSRMRETFLSL 3nvs A 1.021 BS02 SKM A 1 S23 R27 Q172 Y201 D314 K341 S23 R27 Q172 Y201 D314 K341 K22 S23 D49 N94 P119 R124 H128 Q135 Y142 E144 A247 A255 D314 E342 H386 R387 K412 K22 S23 D49 N94 P119 R124 H128 Q135 Y142 E144 A247 A255 D314 E342 H386 R387 K412 2.5.1.19 0003824,0003866,0005737,0008652,0009073,0009423,0016740,0016765 Q9KRB0 428 MESLTLQPIELISGEVNLPGSKSVSNRALLLAALASGTTRLTNLLDSDDIRHMLNALTKLGVNYRLSADKTTCEVEGLGQAFHTTQPLELFLGNAGTAMRPLAAALCLGQGDYVLTGEPRMKERPIGHLVDALRQAGAQIEYLEQENFPPLRIQGTGLQAGTVTIDGSISSQFLTAFLMSAPLAQGKVTIKIVGELVSKPYIDITLHIMEQFGVQVINHDYQEFVIPAGQSYVSPGQFLVEGDASSASYFLAAAAIKGGEVKVTGIGKNSIQGDIQFADALEKMGAQIEWGDDYVIARRGELNAVDLDFNHIPDAAMTIATTALFAKGTTAIRNVYNWRVKETDRLAAMATELRKVGATVEEGEDFIVITPPTKLIHAAIDTYDDHRMAMCFSLVALSDTPVTINDPKCTSKTFPDYFDKFAQLSR 3pgj A 2.49 BS01 SKM A 1 S18 S20 N63 T65 K69 N90 D106 Q248 S14 S16 N59 T61 K65 N86 D102 Q244 1.1.1.25 0003674,0004764,0005575,0005829,0008150,0008652,0009073,0009423,0016491,0019632,0050661 Q9KVT3 279 IDQYAVFGNPINHSKSPFIHTLFARQTQQSMIYTAQCVPVDGFTEAAKHFFAQGGRGCNVTVPFKEEAYRFADRLTERARLAGAVNTLKKLDDGEILGDNTDGEGLVQDLLAQQVLLKGATILLIGAGGAARGVLKPLLDQQPASITVTNRTFAKAEQLAELVAAYGEVKAQAFEQLKQSYDVIINSTSASLDGELPAIDPVIFSSRSVCYDMMYGKGYTVFNQWARQHGCAQAIDGLGMLVGQAAESFMLWRGLRPGTKQILRELRKNLEG 3pgj B 2.49 BS01 SKM B 1 S18 S20 N63 T65 K69 N90 D106 Q248 S11 S13 N56 T58 K62 N83 D99 Q241 1.1.1.25 0003674,0004764,0005575,0005829,0008150,0008652,0009073,0009423,0016491,0019632,0050661 Q9KVT3 279 IDQYAVFGNHSKSPFIHTLFARQTQQSMIYTAQCVPVDGFTEAAKHFFAQGGRGCNVTVPFKEEAYRFADRLTERARLAGAVNTLKKLDDGEILGDNTDGEGLVQDLLAQQVLLKGATILLIGAGGAARGVLKPLLDQQPASITVTNRTFAKAEQLAELVAAYGEVKAQAFEQLKQSYDVIINSTSASLDGELPAIDPVIFSSRSVCYDMMYGKGYTVFNQWARQHGCAQAIDGLGMLVGQAAESFMLWRGLRPGTKQILRELRKNLE 3pgj C 2.49 BS01 SKM C 1 S18 S20 N63 T65 K69 N90 D106 Q248 S14 S16 N59 T61 K65 N86 D102 Q237 1.1.1.25 0003674,0004764,0005575,0005829,0008150,0008652,0009073,0009423,0016491,0019632,0050661 Q9KVT3 279 IDQYAVFGNPINHSKSPFIHTLFARQTQQSMIYTAQCVPVDGFTEAAKHFFAQGGRGCNVTVPFKEEAYRFADRLTERARLAGAVNTLKKLDDGEILGDNTDGEGLVQDLLAQQVLLKGATILLIGAGGAARGVLKPLLDQQPASITVTNRTFAKAEQLAELVAAYGEVKAQAFEQLKQSYDVIINSTSPAIDPVIFSSRSVCYDMMYGKGYTVFNQWARQHGCAQAIDGLGMLVGQAAESFMLWRGLRPGTKQILRELRKNLE 3pgj D 2.49 BS01 SKM D 1 S18 S20 T65 K69 D106 Q248 S14 S16 T61 K65 D102 Q244 1.1.1.25 0003674,0004764,0005575,0005829,0008150,0008652,0009073,0009423,0016491,0019632,0050661 Q9KVT3 279 IDQYAVFGNPINHSKSPFIHTLFARQTQQSMIYTAQCVPVDGFTEAAKHFFAQGGRGCNVTVPFKEEAYRFADRLTERARLAGAVNTLKKLDDGEILGDNTDGEGLVQDLLAQQVLLKGATILLIGAGGAARGVLKPLLDQQPASITVTNRTFAKAEQLAELVAAYGEVKAQAFEQLKQSYDVIINSTSASLDGELPAIDPVIFSSRSVCYDMMYGKGYTVFNQWARQHGCAQAIDGLGMLVGQAAESFMLWRGLRPGTKQILRELRKNLE 3phh A 1.42 BS01 SKM A 1 S16 S18 N63 T65 K69 N90 D105 Y210 L234 Q237 S16 S18 N63 T65 K69 N90 D105 Y207 L231 Q234 1.1.1.25 0004764,0005829,0008652,0009073,0009423,0016491,0019632,0050661 P56119 500 MKLKSFGVFGNPIKHSKSPLIHNACFLTFQKELRFLGHYHPILLPLESHIKSEFLHLGLSGANVTLPFKERAFQVCDKIKGIALECGAVNTLVLENDELVGYNTDALGFYLSLKYQNALILGAGGSAKALACELKKQGLQVSVLNRSSRGLDFFQRLGCDCFMEPPKSAFDLIINATSASLHNELPLNKEVLKGYFKEGKLAYDLAYGFLTPFLSLAKELKTPFQDGKDMLIYQAALSFEKFSASQIPYSKAFEVMRSVF 3phi A 2.04 BS01 SKM A 1 S16 S18 N63 K69 N90 D105 Y210 Q237 S16 S18 N63 K69 N90 D105 Y207 Q234 1.1.1.25 0004764,0005829,0008652,0009073,0009423,0016491,0019632,0050661 P56119 500 MKLKSFGVFGNPIKHSKSPLIHNACFLTFQKELRFLGHYHPILLPLESHIKSEFLHLGLSGANVTLPFKERAFQVCDKIKGIALECGAVNTLVLENDELVGYNTDALGFYLSLKYQNALILGAGGSAKALACELKKQGLQVSVLNRSSRGLDFFQRLGCDCFMEPPKSAFDLIINATSASLHNELPLNKEVLKGYFKEGKLAYDLAYGFLTPFLSLAKELKTPFQDGKDMLIYQAALSFEKFSASQIPYSKAFEVMRSV 3phi B 2.04 BS01 SKM B 1 S16 S18 N63 T65 K69 N90 D105 Y210 Q237 S16 S18 N63 T65 K69 N90 D105 Y207 Q234 1.1.1.25 0004764,0005829,0008652,0009073,0009423,0016491,0019632,0050661 P56119 500 MKLKSFGVFGNPIKHSKSPLIHNACFLTFQKELRFLGHYHPILLPLESHIKSEFLHLGLSGANVTLPFKERAFQVCDKIKGIALECGAVNTLVLENDELVGYNTDALGFYLSLKYQNALILGAGGSAKALACELKKQGLQVSVLNRSSRGLDFFQRLGCDCFMEPPKSAFDLIINATSASLHNELPLNKEVLKGYFKEGKLAYDLAYGFLTPFLSLAKELKTPFQDGKDMLIYQAALSFEKFSASQIPYSKAFEVMRSV 3sef B 2.4 BS02 SKM B 1 S18 S20 N63 T65 K69 D106 Q248 S11 S13 N56 T58 K62 D99 Q241 1.1.1.25 0003674,0004764,0005575,0005829,0008150,0008652,0009073,0009423,0016491,0019632,0050661 Q9KVT3 280 IDQYAVFGNHSKSPFIHTLFARQTQQSMIYTAQCVPVDGFTEAAKHFFAQGGRGCNVTVPFKEEAYRFADRLTERARLAGAVNTLKKLDDGEILGDNTDGEGLVQDLLAQQVLLKGATILLIGAGGAARGVLKPLLDQQPASITVTNRTFAKAEQLAELVAAYGEVKAQAFEQLKQSYDVIINSTSASLDGELPAIDPVIFSSRSVCYDMMYGKGYTVFNQWARQHGCAQAIDGLGMLVGQAAESFMLWRGLRPGTKQILRELRKNLEG 3sef C 2.4 BS01 SKM C 1 S18 S20 K69 D106 Q248 S14 S16 K65 D101 Q217 1.1.1.25 0003674,0004764,0005575,0005829,0008150,0008652,0009073,0009423,0016491,0019632,0050661 Q9KVT3 279 IDQYAVFGNPINHSKSPFIHTLFARQTQQSMIYTAQCVPVDGFTEAAKHFFAQGGRGCNVTVPFKEEAYRFADRLTERARLAGAVNTLKKDDGEILGDNTDGEGLVQDLLAQQVLLKGATILLIGAGGAARGVLKPLLDQQPASITVTNRTFAKAEQLAELVAAYGEVKAQAFEQLKQSYDVIINSTSAIDPVIFSSRSVCYDMMYGIDGLGMLVGQAAESFMLWRGLRPGTKQILRELRKNLE 3slh A 1.7 BS03 SKM A 1 S22 R26 Q169 R194 D315 K342 S23 R27 Q170 R195 D316 K343 K21 S22 D48 N93 R123 D315 E343 H386 R387 T413 K22 S23 D49 N94 R124 D316 E344 H387 R388 T414 2.5.1.19 0003824,0003866,0005737,0008652,0009073,0009423,0016740,0016765 Q83E11 445 AMDYQTIPSQGLSGEICVPGDKSISHRAVLLAAIAEGQTQVDGFLMGADNLAMVSALQQMGASIQVIEDENILVVEGVGMTGLQAPPEALDCGNSGTAIRLLSGLLAGQPFNTVLTGDSSLQRRPMKRIIDPLTLMGAKIDSTGNVPPLKIYGNPRLTGIHYQLPMASAQVKSCLLLAGLYARGKTCITEPAPSRDHTERLLKHFHYTLQKDKQSICVSGGGKLKANDISIPGDISSAAFFIVAATITPGSAIRLCRVGVNPTRLGVINLLKMMGADIEVTHYTEKNEEPTADITVRHARLKGIDIPPDQVPLTIDEFPVLLIAAAVAQGKTVLRDAAELRVKETDRIAAMVDGLQKLGIAAESLPDGVIIQGGTLEGGEVNSYDDHRIAMAFAVAGTLAKGPVRIRNCDNVKTSFPNFVELANEVGMNVKGVRGR 3slh B 1.7 BS03 SKM B 1 S22 R26 Q169 R194 D315 K342 S23 R27 Q170 R195 D316 K343 K21 S22 D48 N93 R123 D315 E343 H386 R387 T413 K22 S23 D49 N94 R124 D316 E344 H387 R388 T414 2.5.1.19 0003824,0003866,0005737,0008652,0009073,0009423,0016740,0016765 Q83E11 443 AMDYQTIPSQGLSGEICVPGDKSISHRAVLLAAIAEGQTQVDGFLMGADNLAMVSALQQMGASIQVIEDENILVVEGVGMTGLQAPPEALDCGNSGTAIRLLSGLLAGQPFNTVLTGDSSLQRRPMKRIIDPLTLMGAKIDSTGNVPPLKIYGNPRLTGIHYQLPMASAQVKSCLLLAGLYARGKTCITEPAPSRDHTERLLKHFHYTLQKDKQSICVSGGGKLKANDISIPGDISSAAFFIVAATITPGSAIRLCRVGVNPTRLGVINLLKMMGADIEVTHYTEKNEEPTADITVRHARLKGIDIPPDQVPLTIDEFPVLLIAAAVAQGKTVLRDAAELRVKETDRIAAMVDGLQKLGIAAESLPDGVIIQGGTLEGGEVNSYDDHRIAMAFAVAGTLAKGPVRIRNCDNVKTSFPNFVELANEVGMNVKGVRGRGGF 3slh C 1.7 BS02 SKM C 1 S22 R26 T96 Q169 D315 K342 S24 R28 T98 Q171 D317 K344 K21 S22 D48 N93 R123 D315 E343 H386 R387 T413 K23 S24 D50 N95 R125 D317 E345 H388 R389 T415 2.5.1.19 0003824,0003866,0005737,0008652,0009073,0009423,0016740,0016765 Q83E11 443 NAMDYQTIPSQGLSGEICVPGDKSISHRAVLLAAIAEGQTQVDGFLMGADNLAMVSALQQMGASIQVIEDENILVVEGVGMTGLQAPPEALDCGNSGTAIRLLSGLLAGQPFNTVLTGDSSLQRRPMKRIIDPLTLMGAKIDSTGNVPPLKIYGNPRLTGIHYQLPMASAQVKSCLLLAGLYARGKTCITEPAPSRDHTERLLKHFHYTLQKDKQSICVSGGGKLKANDISIPGDISSAAFFIVAATITPGSAIRLCRVGVNPTRLGVINLLKMMGADIEVTHYTEKNEEPTADITVRHARLKGIDIPPDQVPLTIDEFPVLLIAAAVAQGKTVLRDAAELRVKETDRIAAMVDGLQKLGIAAESLPDGVIIQGGTLEGGEVNSYDDHRIAMAFAVAGTLAKGPVRIRNCDNVKTSFPNFVELANEVGMNVKGVRGRG 3slh D 1.7 BS03 SKM D 1 S22 R26 T96 Q169 R194 D315 K342 S24 R28 T98 Q171 R196 D317 K344 K21 S22 D48 N93 R123 D315 E343 H386 R387 T413 K23 S24 D50 N95 R125 D317 E345 H388 R389 T415 2.5.1.19 0003824,0003866,0005737,0008652,0009073,0009423,0016740,0016765 Q83E11 443 NAMDYQTIPSQGLSGEICVPGDKSISHRAVLLAAIAEGQTQVDGFLMGADNLAMVSALQQMGASIQVIEDENILVVEGVGMTGLQAPPEALDCGNSGTAIRLLSGLLAGQPFNTVLTGDSSLQRRPMKRIIDPLTLMGAKIDSTGNVPPLKIYGNPRLTGIHYQLPMASAQVKSCLLLAGLYARGKTCITEPAPSRDHTERLLKHFHYTLQKDKQSICVSGGGKLKANDISIPGDISSAAFFIVAATITPGSAIRLCRVGVNPTRLGVINLLKMMGADIEVTHYTEKNEEPTADITVRHARLKGIDIPPDQVPLTIDEFPVLLIAAAVAQGKTVLRDAAELRVKETDRIAAMVDGLQKLGIAAESLPDGVIIQGGTLEGGEVNSYDDHRIAMAFAVAGTLAKGPVRIRNCDNVKTSFPNFVELANEVGMNVKGVRGRGGF 3t39 D 2.7 BS01 SKM D 1 R31 R138 R31 R138 Y71 T152 Y71 T152 ? 0001818,0005576,0008270,0008745,0009253,0016019,0016045,0042742,0042834,0045087,0050830 Q9GK12 6873 EDPPACGSIVPRREWRALASECRERLTRPVRYVVVSHTAGSHCDTPASCAQQAQNVQSYHVRNLGWCDVGYNFLIGEDGLVYEGRGWNIKGAHAGPTWNPISIGISFMGNYMNRVPPPRALRAAQNLLACGVALGALRSNYEVKGHRDVQPTLSPGDRLYEIIQTWSHYRA 3tnl A 1.45 BS02 SKM A 1 S26 S28 N71 S73 K77 N98 D113 Q268 S23 S25 N68 S70 K74 N95 D110 Q265 1.1.1.25 0004764,0008652,0009073,0009423,0016491,0019632,0050661 Q8Y9N5 293 KITERITGHTELIGLIATPIRHSLSPTMHNEAFAKLGLDYVYLAFEVGDKELKDVVQGFRAMNLRGWNVSMPNKTNIHKYLDKLSPAAELVGAVNTVVNDDGVLTGHITDGTGYMRALKEAGHDIIGKKMTICGAGGAATAICIQAALDGVKEISIFNRKDDFYANAEKTVEKINSKTDCKAQLFDIEDHEQLRKEIAESVIFTNATGVGMKPFEGETLLPSADMLRPELIVSDVVYKPTKTRLLEIAEEQGCQTLNGLGMMLWQGAKAFEIWTHKEMPVDYIKEILF 3tnl C 1.45 BS02 SKM C 1 S26 S28 N71 K77 N98 D113 Q268 S24 S26 N69 K75 N96 D111 Q266 1.1.1.25 0004764,0008652,0009073,0009423,0016491,0019632,0050661 Q8Y9N5 293 NKITERITGHTELIGLIATPIRHSLSPTMHNEAFAKLGLDYVYLAFEVGDKELKDVVQGFRAMNLRGWNVSMPNKTNIHKYLDKLSPAAELVGAVNTVVNDDGVLTGHITDGTGYMRALKEAGHDIIGKKMTICGAGGAATAICIQAALDGVKEISIFNRKDDFYANAEKTVEKINSKTDCKAQLFDIEDHEQLRKEIAESVIFTNATGVGMKPFEGETLLPSADMLRPELIVSDVVYKPTKTRLLEIAEEQGCQTLNGLGMMLWQGAKAFEIWTHKEMPVDYIKEILF 4fos A 1.72 BS01 SKM A 1 S16 S18 N63 V64 T65 K69 N90 D105 Y210 L234 S16 S18 N63 V64 T65 K69 N90 D105 Y210 L234 1.1.1.25 0004764,0005829,0008652,0009073,0009423,0016491,0019632,0050661 P56119 500 MKLKSFGVFGNPIKHSKSPLIHNACFLTFQKELRFLGHYHPILLPLESHIKSEFLHLGLSGANVTLPFKERAFQVCDKIKGIALECGAVNTLVLENDELVGYNTDALGFYLSLKQKNYQNALILGAGGSAKALACELKKQGLQVSVLNRSSRGLDFFQRLGCDCFMEPPKSAFDLIINATSASLHNELPLNKEVLKGYFKEGKLAYDLAYGFLTPFLSLAKELKTPFQDGKDMLIYAAALSFEKFSASQIPYSKAFEVMRSVF 4fq8 A 2.07 BS01 SKM A 1 S16 S18 N63 T65 K69 N90 D105 Q237 S16 S18 N63 T65 K69 N90 D105 Q237 1.1.1.25 0004764,0005829,0008652,0009073,0009423,0016491,0019632,0050661 P56119 500 MKLKSFGVFGNPIKHSKSPLIHNACFLTFQKELRFLGHYHPILLPLESHIKSEFLHLGLSGANVTLPFKERAFQVCDKIKGIALECGAVNTLVLENDELVGYNTDALGFYLSLKQKNYQNALILGAGGSAKALACELKKQGLQVSVLNRSSRGLDFFQRLGCDCFMEPPKSAFDLIINATSASLHNELPLNKEVLKGYFKEGKLAYDLAAGFLTPFLSLAKELKTPFQDGKDMLIYQAALSFEKFSASQIPYSKAFEVMRSVF 4fq8 B 2.07 BS01 SKM B 1 S16 S18 N63 T65 K69 N90 D105 Q237 S16 S18 N63 T65 K69 N90 D105 Q237 1.1.1.25 0004764,0005829,0008652,0009073,0009423,0016491,0019632,0050661 P56119 500 MKLKSFGVFGNPIKHSKSPLIHNACFLTFQKELRFLGHYHPILLPLESHIKSEFLHLGLSGANVTLPFKERAFQVCDKIKGIALECGAVNTLVLENDELVGYNTDALGFYLSLKQKNYQNALILGAGGSAKALACELKKQGLQVSVLNRSSRGLDFFQRLGCDCFMEPPKSAFDLIINATSASLHNELPLNKEVLKGYFKEGKLAYDLAAGFLTPFLSLAKELKTPFQDGKDMLIYQAALSFEKFSASQIPYSKAFEVMRSVF 4fr5 A 2.2 BS01 SKM A 1 S16 S18 N63 T65 K69 N90 D105 Q237 S16 S18 N63 T65 K69 N90 D105 Q237 1.1.1.25 0004764,0005829,0008652,0009073,0009423,0016491,0019632,0050661 P56119 500 MKLKSFGVFGNPIKHSKSPLIHNACFLTFQKELRFLGHYHPILLPLESHIKSEFLHLGLSGANVTLPFKERAFQVCDKIKGIALECGAVNTLVLENDELVGYNTDALGFYLSLKQKNYQNALILGAGGSAKALACELKKQGLQVSVLNRSSRGLDFFQRLGCDCFMEPPKSAFDLIINATSASLHNELPLNKEVLKGYFKEGKLAYDLASGFLTPFLSLAKELKTPFQDGKDMLIYQAALSFEKFSASQIPYSKAFEVMRSVF 4fr5 B 2.2 BS01 SKM B 1 S16 S18 N63 T65 K69 N90 D105 Q237 S16 S18 N63 T65 K69 N90 D105 Q237 1.1.1.25 0004764,0005829,0008652,0009073,0009423,0016491,0019632,0050661 P56119 500 MKLKSFGVFGNPIKHSKSPLIHNACFLTFQKELRFLGHYHPILLPLESHIKSEFLHLGLSGANVTLPFKERAFQVCDKIKGIALECGAVNTLVLENDELVGYNTDALGFYLSLKQKNYQNALILGAGGSAKALACELKKQGLQVSVLNRSSRGLDFFQRLGCDCFMEPPKSAFDLIINATSASLHNELPLNKEVLKGYFKEGKLAYDLASGFLTPFLSLAKELKTPFQDGKDMLIYQAALSFEKFSASQIPYSKAFEVMRSVF 4fsh A 2.85 BS01 SKM A 1 S16 S18 N63 K69 N90 D105 Y210 Q237 S16 S18 N63 K69 N90 D105 Y207 Q234 1.1.1.25 0004764,0005829,0008652,0009073,0009423,0016491,0019632,0050661 P56119 500 MKLKSFGVFGNPIKHSKSPLIHNACFLTFQKKLGFLGHYRPILLPLESHIKNEFLHLGLSGANVTLPFKERAFQVCDKIKGIALECASINTLVLENDELVGYNTDALGFYLSLKHQNYQNALILGSGGSAKALACGLKKQGLKVSVLNRSPRGLDFFQRLGCDCFMEPPKSAFDLIINATSASLNPLNKEVLKGYFKEAKLAYDLAYGFLTPFLALAKELKIPFQDGKDMLIYQASLSFEKFSASQIPYSKAFEVMRSVF 4guj A 1.5 BS01 SKM A 1 E46 R48 R82 H143 R213 F225 S232 A233 Q236 E45 R47 R81 H142 R212 F224 S231 A232 Q235 E86 H143 K170 E85 H142 K169 4.2.1.10 0003855,0008652,0009073,0009423,0016829,0046279 -logKd/Ki=3.05, Kd=0.9mM P58687 24437575 301 KTVTVRDLVVGEGAPKIIVSLMGKTITDVKSEALAYREADFDILEWRVDHFANVTTAESVLEAAGAIREIITDKPLLFTFRSAKEGGEQALTTGQYIDLNRAAVDSGLVDMIDLELFTGDDEVKATVGYAHQHNVAVIMSNHDFHKTPAAEEIVQRLRKMQELGADIPKIAVMPQTKADVLTLLTATVEMQERYADRPIITMSMSKTGVISRLAGEVFGSAATFGAVKKASAPGQISVADLRTVLTILHQA 4guj B 1.5 BS01 SKM B 1 S21 E46 K170 M203 R213 F225 S20 E45 K169 M202 R212 F224 E86 H143 K170 E85 H142 K169 4.2.1.10 0003855,0008652,0009073,0009423,0016829,0046279 P58687 24437575 303 KTVTVRDLVVGEGAPKIIVSLMGKTITDVKSEALAYREADFDILEWRVDHFANVTTAESVLEAAGAIREIITDKPLLFTFRSAKEGGEQALTTGQYIDLNRAAVDSGLVDMIDLELFTGDDEVKATVGYAHQHNVAVIMSNHDFHKTPAAEEIVQRLRKMQELGADIPKIAVMPQTKADVLTLLTATVEMQERYADRPIITMSMSKTGVISRLAGEVFGSAATFGAVKKASAPGQISVADLRTVLTILHQA 4p4g A 1.7 BS01 SKM A 1 S18 S20 T65 K69 N90 D105 Y215 L240 Q243 S14 S16 T61 K65 N86 D101 Y211 L236 Q239 1.1.1.25 0004764,0005737,0005829,0009423,0019632,0050661 I6Y120 301 PKKAGVLGSPIAHSRSPQLHLAAYRALGLHDWTYERIECGAAELPVVVGGFGPEWVGVSVTMPGKFAALRFADERTARADLVGSANTLVRTPHGWRADNTDIDGVAGALGAAAGHALVLGSGGTAPAAVVGLAELGVTDITVVARNSDKAARLVDLGTRVGVATRFCAFDSGGLADAVAAAEVLVSTIPAEVAAGYAGTLAAIPVLLDAIYDPWPTPLAAAVGSAGGRVISGLQMLLHQAFAQVEQFTGLPAPREAMTCALAALD 4p4l A 2.009 BS01 SKM A 1 S18 S20 T65 K69 N90 D105 L240 Q243 S14 S16 T61 K65 N86 D101 L236 Q239 1.1.1.25 0004764,0005737,0005829,0009423,0019632,0050661 I6Y120 301 PKKAGVLGSPIAHSRSPQLHLAAYRALGLHDWTYERIECGAAELPVVVGGFGPEWVGVSVTMPGKFAALRFADERTARADLVGSANTLVRTPHGWRADNTDIDGVAGALGAAAGHALVLGSGGTAPAAVVGLAELGVTDITVVARNSDKAARLVDLGTRVGVATRFCAFDSGGLADAVAAAEVLVSTIPAEVAAGYAGTLAAIPVLLDAIYDPWPTPLAAAVGSAGGRVISGLQMLLHQAFAQVEQFTGLPAPREAMTCALAAL 4p4l B 2.009 BS01 SKM B 1 S18 S20 T65 K69 N90 D105 L240 Q243 S14 S16 T61 K65 N86 D101 L229 Q232 1.1.1.25 0004764,0005737,0005829,0009423,0019632,0050661 I6Y120 301 PKKAGVLGSPIAHSRSPQLHLAAYRALGLHDWTYERIECGAAELPVVVGGFGPEWVGVSVTMPGKFAALRFADERTARADLVGSANTLVRTPHGWRADNTDIDGVAGALGAAGHALVLGSGGTAPAAVVGLAELGVTDITVVARNSDKAARLVDLGTRVGVATRFCAFDAVAAAEVLVSTIPAEVAAGYAGTLAAIPVLLDAIYDPWPTPLAAAVGSAGGRVISGLQMLLHQAFAQVEQFTGLPAPREAMTCALAAL 4p4l C 2.009 BS01 SKM C 1 S18 S20 T65 K69 N90 D105 Q243 Q247 S14 S16 T61 K65 N86 D101 Q238 Q242 1.1.1.25 0004764,0005737,0005829,0009423,0019632,0050661 I6Y120 301 PKKAGVLGSPIAHSRSPQLHLAAYRALGLHDWTYERIECGAAELPVVVGGFGPEWVGVSVTMPGKFAALRFADERTARADLVGSANTLVRTPHGWRADNTDIDGVAGALGAAAHALVLGSGGTAPAAVVGLAELGVTDITVVARNSDKAARLVDLGTRVGVATRFCAFDSGGLADAVAAAEVLVSTIPAEVAAGYAGTLAAIPVLLDAIYDPWPTPLAAAVGSAGGRVISGLQMLLHQAFAQVEQFTGLPAPREAMTCALAAL 4y0a A 1.911 BS01 SKM A 1 M27 D50 F73 R74 G96 G97 L136 R153 M17 D40 F63 R64 G86 G87 L126 R143 2.7.1.71 0000287,0004765,0005524,0005737,0005829,0008652,0009073,0009423,0016301,0016310,0019752,0046872 -logKd/Ki=2.31, Ki=4950uM A0A0M3KL09 26249354 201 PSKAFETLPNIYLVGPMGAGKTTVGRHLAELLGREFLDSDHEIERKTGATIPWIFEKEGEVGFRTRETVVLNELTSRKALVLATGGGAITQAPNREFLKQRGIVVYLYTPVELQLQRTYRDKNRPLLQVENPEQKLRDLLKIRDPLYREVAHYTIETNQGAARDLAQKILQLILSNKLK 5ted A 1.889 BS02 SKM A 1 I98 Y99 T131 F196 S200 G201 E224 D226 I10 Y11 T43 F108 S112 G113 E136 D138 ? Q8Y9N7 29530613 401 SHGNIDLGFIYTMGAHTVPELVQNFTKVESHKDITFSFFQGATKSIIPDLKNEKFDLAICSYVENEPDIEFLPLTKQELVVVVAENHPLAKYDSIDLQDTADYSYIFFSDTSGLRPLIDSLFAEINIQPKIGCYVEEDTAMVGLVSVDYGISIMPKISSLAHYNVKVLSINEPKHDRFIYLASLKNHYISPASKAFKDFALRYGKKHFL 5ted B 1.889 BS01 SKM B 1 I98 Y99 T131 S149 F196 S200 G201 E224 D226 R265 I10 Y11 T43 S61 F108 S112 G113 E136 D138 R177 ? Q8Y9N7 29530613 401 SHGNIDLGFIYTMGAHTVPELVQNFTKVESHKDITFSFFQGATKSIIPDLKNEKFDLAICSYVENEPDIEFLPLTKQELVVVVAENHPLAKYDSIDLQDTADYSYIFFSDTSGLRPLIDSLFAEINIQPKIGCYVEEDTAMVGLVSVDYGISIMPKISSLAHYNVKVLSINEPKHDRFIYLASLKNHYISPASKAFKDFALRYGKKHFLR 6bmb A 2.077 BS01 SKM A 1 I328 S336 S338 K385 D423 Y550 Q578 Q582 I239 S247 S249 K296 D334 Y436 Q464 Q468 E159 H214 K241 E70 H125 K152 1.1.1.25,4.2.1.10 0003855,0004764,0019632,0050661 Q9SQT8 29890023 704 VKNPSLICAPVMADSIDKMVIETSKAHELGADLVEIRLDWLKDFNPLEDLKTIIKKSPLPTLFTYRPKWEGGQYEGDENERRDVLRLAMELGADYIDVELQVASEFIKSIDGKKPGKFKVIVSSHNYQNTPSVEDLDGLVARIQQTGADIVKIATTAVDIADVARMFHITSKAQVPTIGLVMGERGLMSRILCSKFGGYLTFGTLDSSKVSAPGQPTIKDLLDLYNFRRIGPDTKVYGIIGKPVSHSKSPIVHNQAFKSVDFNGVYVHLLVDNLVSFLQAYSSSDFAGFSCGIPHKEAALQCCDEVDPLAKSIGAVNTILRRKSDGKLLGYNTDCIGSISAIEDGLTVVVIGAGGAGKALAYGAKEKGAKVVIANRTYERELAEAIGALSLTDLDNYEDGMVLANTTSMGMQPNVEETPISKDALKHYALVFDAVYTPRITRLLREAEESGAITVSGSEMFVRQAYEQFEIFTGLPAPKELYWQIMSKYGSRENLYFQ 6hqv A 3.0 BS05 SKM A 1 S1303 S1305 T1349 K1353 N1374 D1394 Q1552 S1277 S1279 T1323 K1327 N1348 D1368 Q1526 R137 K159 E201 K257 E267 R271 N275 H278 H282 H294 R123 K145 E187 K243 E253 R257 N261 H264 H268 H280 1.1.1.25,2.5.1.19,2.7.1.71,4.2.1.10,4.2.3.4 0003824,0003855,0003856,0003866,0004764,0004765,0005524,0005737,0008652,0009073,0009423,0016301,0016310,0016491,0016765,0016829,0046872 G0S061 32632294 1606 EPTRIAILGKEDIIVDHGIWLNFVAHDLLQTLPSSTYVLITDTNLYTTYVPPFQAVFEAAAPRDVRLLTYAIPPGEYSKSRETKAEIEDWMLSHACTRDTVIIALGGGVIGDMIGYVAATFMRGVRFVQVPTTLLAMVDSSIGGKTAIDTPMGKNLIGAFWQPRRIYIDLAFLETLPVREFINGMAEVIKTAAIWNETEFTALEENAAAILEAVRSKASSPAARLAPIRHILKRIVLGSARVKAEVVSADEREGGLRNLLNFGHSIGHAYEAILAPQVLHGECVAIGMVKEAELARYLGVLRPSAVARLTKLIASYDLPTSVHDKRIAKLSAGKECPVDVLLQKMAVDKKNEGRKKKIVLLSAIGKTYEKKATVVDDRAIRLVLSPSVRVTPGVPKGLSVTVTPPGSKSISNRALVLAALGEGTTRIHGLLHSDDVQYMLAAIEQLHGADFSWEDAGEILVVTGKGGKLQASKEPLYLGNAGTASRFLTSVVALCAPSAVSSTVLTGNARMKVRPIGALVDALRANGVGVKYLEKEKSLPVEVDAAGGFAGGVIELAATVSSQYVSSILMAAPYAHQPVTLRLVGGKPISQPYIDMTIAMMASFGIKVERSAEDPNTYLIPKGVYKNPPEYVVESDASSATYPLAVAAITGTTCTIPNIGSESLQGDARFAVEVLRPMGCAVEQTATSTTVTGPPIGTLKAIPHVDMEPMTDAFLTAAVLAAVADGTTQITGIANQRVKECNRIAAMKDQLAKFGVQCNELEDGIEVIGKPYQELRNPVEGIYCYDDHRVAMSHSVLSTISPHPVLILERECTAKTWPGWWDILSQFFKVQLDGEEDPTGTDRSIFIVGMRGAGKSTAGRWMSELLKRPLVDLDAELERREGMTIPEIIRGERGWEGFRQAELELLQDVIKNQSKGYIFSCGGGIVETEAARKLLIDYHKNGGPVLLVHRDTDQVVEYLMRDKTRPAYSENIREVYERRKPWFYECSNLQYHSPHEDGSEALLQPPADFARFVKLIAGQSTHLEDVRAKKHSFFVSLTVPNVADALDIIPRVVVGSDAVELRVDLLESYEPEFVARQVALLRAAAQVPIVYTVRTQSQGGKFPDEDYDLALRLYQTGLRSGVEYLDLEMTMPDHILQAVTDAKGFTSIIASHHDPQCKLSWKSGSWIPFYNKALQYGDVIKLVGVAREMADNFALTNFKAKMLAAHDNKPMIALNMGTAGKLSRVLNGFLTPVSHPALPSKAAPGQLSATEIRQALSLIGEIEPKSFYLFGKPISASRSPALHNTLFYKTGLPHHYSRFETDEASKALESLIRSPDFGGASVTIPLKLDIMPLLDSATDAARTIGAVNTIIPQTRDGSTTTLVGDNTDWRGMVHALLHSSGSGSVVQRTAAPRGAAMVVGSGGTARAAIYALHDLGFAPIWIVARSEERVAELVRGFDGYDLRRMTSPHQGKDNMPSVVISTIPATQPIDPSMREVIVEVLKHGHPSAEGKVLLEMAYQPPRTPLMTLAEDQGWRTVGGLEVLAAQGWYQFQLWTGITPLYEEARAAVMGEDSVE 6hqv A 3.0 BS06 SKM A 2 D900 G949 G950 R1005 D874 G923 G924 R979 R137 K159 E201 K257 E267 R271 N275 H278 H282 H294 R123 K145 E187 K243 E253 R257 N261 H264 H268 H280 1.1.1.25,2.5.1.19,2.7.1.71,4.2.1.10,4.2.3.4 0003824,0003855,0003856,0003866,0004764,0004765,0005524,0005737,0008652,0009073,0009423,0016301,0016310,0016491,0016765,0016829,0046872 G0S061 32632294 1607 EPTRIAILGKEDIIVDHGIWLNFVAHDLLQTLPSSTYVLITDTNLYTTYVPPFQAVFEAAAPRDVRLLTYAIPPGEYSKSRETKAEIEDWMLSHACTRDTVIIALGGGVIGDMIGYVAATFMRGVRFVQVPTTLLAMVDSSIGGKTAIDTPMGKNLIGAFWQPRRIYIDLAFLETLPVREFINGMAEVIKTAAIWNETEFTALEENAAAILEAVRSKASSPAARLAPIRHILKRIVLGSARVKAEVVSADEREGGLRNLLNFGHSIGHAYEAILAPQVLHGECVAIGMVKEAELARYLGVLRPSAVARLTKLIASYDLPTSVHDKRIAKLSAGKECPVDVLLQKMAVDKKNEGRKKKIVLLSAIGKTYEKKATVVDDRAIRLVLSPSVRVTPGVPKGLSVTVTPPGSKSISNRALVLAALGEGTTRIHGLLHSDDVQYMLAAIEQLHGADFSWEDAGEILVVTGKGGKLQASKEPLYLGNAGTASRFLTSVVALCAPSAVSSTVLTGNARMKVRPIGALVDALRANGVGVKYLEKEKSLPVEVDAAGGFAGGVIELAATVSSQYVSSILMAAPYAHQPVTLRLVGGKPISQPYIDMTIAMMASFGIKVERSAEDPNTYLIPKGVYKNPPEYVVESDASSATYPLAVAAITGTTCTIPNIGSESLQGDARFAVEVLRPMGCAVEQTATSTTVTGPPIGTLKAIPHVDMEPMTDAFLTAAVLAAVADGTTQITGIANQRVKECNRIAAMKDQLAKFGVQCNELEDGIEVIGKPYQELRNPVEGIYCYDDHRVAMSHSVLSTISPHPVLILERECTAKTWPGWWDILSQFFKVQLDGEEDPTGTDRSIFIVGMRGAGKSTAGRWMSELLKRPLVDLDAELERREGMTIPEIIRGERGWEGFRQAELELLQDVIKNQSKGYIFSCGGGIVETEAARKLLIDYHKNGGPVLLVHRDTDQVVEYLMRDKTRPAYSENIREVYERRKPWFYECSNLQYHSPHEDGSEALLQPPADFARFVKLIAGQSTHLEDVRAKKHSFFVSLTVPNVADALDIIPRVVVGSDAVELRVDLLESYEPEFVARQVALLRAAAQVPIVYTVRTQSQGGKFPDEDYDLALRLYQTGLRSGVEYLDLEMTMPDHILQAVTDAKGFTSIIASHHDPQCKLSWKSGSWIPFYNKALQYGDVIKLVGVAREMADNFALTNFKAKMLAAHDNKPMIALNMGTAGKLSRVLNGFLTPVSHPALPSKAAPGQLSATEIRQALSLIGEIEPKSFYLFGKPISASRSPALHNTLFYKTGLPHHYSRFETDEASKALESLIRSPDFGGASVTIPLKLDIMPLLDSATDAARTIGAVNTIIPQTRDGSTTTLVGDNTDWRGMVHALLHSSGSGSVVQRTAAPRGAAMVVGSGGTARAAIYALHDLGFAPIWIVARSEERVAELVRGFDGYDLRRMTSPHQGKDNMPSVVISTIPATQPIDPSMREVIVEVLKHGHPSAEGKVLLEMAYQPPRTPLMTLAEDQGWRTVGGLEVLAAQGWYQFQLWTGITPLYEEARAAVMGEDSVE 6hqv A 3.0 BS07 SKM A 3 R427 S576 Q577 R413 S562 Q563 R137 K159 E201 K257 E267 R271 N275 H278 H282 H294 R123 K145 E187 K243 E253 R257 N261 H264 H268 H280 1.1.1.25,2.5.1.19,2.7.1.71,4.2.1.10,4.2.3.4 0003824,0003855,0003856,0003866,0004764,0004765,0005524,0005737,0008652,0009073,0009423,0016301,0016310,0016491,0016765,0016829,0046872 G0S061 32632294 1609 EPTRIAILGKEDIIVDHGIWLNFVAHDLLQTLPSSTYVLITDTNLYTTYVPPFQAVFEAAAPRDVRLLTYAIPPGEYSKSRETKAEIEDWMLSHACTRDTVIIALGGGVIGDMIGYVAATFMRGVRFVQVPTTLLAMVDSSIGGKTAIDTPMGKNLIGAFWQPRRIYIDLAFLETLPVREFINGMAEVIKTAAIWNETEFTALEENAAAILEAVRSKASSPAARLAPIRHILKRIVLGSARVKAEVVSADEREGGLRNLLNFGHSIGHAYEAILAPQVLHGECVAIGMVKEAELARYLGVLRPSAVARLTKLIASYDLPTSVHDKRIAKLSAGKECPVDVLLQKMAVDKKNEGRKKKIVLLSAIGKTYEKKATVVDDRAIRLVLSPSVRVTPGVPKGLSVTVTPPGSKSISNRALVLAALGEGTTRIHGLLHSDDVQYMLAAIEQLHGADFSWEDAGEILVVTGKGGKLQASKEPLYLGNAGTASRFLTSVVALCAPSAVSSTVLTGNARMKVRPIGALVDALRANGVGVKYLEKEKSLPVEVDAAGGFAGGVIELAATVSSQYVSSILMAAPYAHQPVTLRLVGGKPISQPYIDMTIAMMASFGIKVERSAEDPNTYLIPKGVYKNPPEYVVESDASSATYPLAVAAITGTTCTIPNIGSESLQGDARFAVEVLRPMGCAVEQTATSTTVTGPPIGTLKAIPHVDMEPMTDAFLTAAVLAAVADGTTQITGIANQRVKECNRIAAMKDQLAKFGVQCNELEDGIEVIGKPYQELRNPVEGIYCYDDHRVAMSHSVLSTISPHPVLILERECTAKTWPGWWDILSQFFKVQLDGEEDPTGTDRSIFIVGMRGAGKSTAGRWMSELLKRPLVDLDAELERREGMTIPEIIRGERGWEGFRQAELELLQDVIKNQSKGYIFSCGGGIVETEAARKLLIDYHKNGGPVLLVHRDTDQVVEYLMRDKTRPAYSENIREVYERRKPWFYECSNLQYHSPHEDGSEALLQPPADFARFVKLIAGQSTHLEDVRAKKHSFFVSLTVPNVADALDIIPRVVVGSDAVELRVDLLESYEPEFVARQVALLRAAAQVPIVYTVRTQSQGGKFPDEDYDLALRLYQTGLRSGVEYLDLEMTMPDHILQAVTDAKGFTSIIASHHDPQCKLSWKSGSWIPFYNKALQYGDVIKLVGVAREMADNFALTNFKAKMLAAHDNKPMIALNMGTAGKLSRVLNGFLTPVSHPALPSKAAPGQLSATEIRQALSLIGEIEPKSFYLFGKPISASRSPALHNTLFYKTGLPHHYSRFETDEASKALESLIRSPDFGGASVTIPLKLDIMPLLDSATDAARTIGAVNTIIPQTRDGSTTTLVGDNTDWRGMVHALLHSSGSGSVVQRTAAPRGAAMVVGSGGTARAAIYALHDLGFAPIWIVARSEERVAELVRGFDGYDLRRMTSPHQGKDNMPSVVISTIPATQPIDPSMREVIVEVLKHGHPSAEGKVLLEMAYQPPRTPLMTLAEDQGWRTVGGLEVLAAQGWYQFQLWTGITPLYEEARAAVMGEDSVE 6hqv B 3.0 BS05 SKM B 1 S1303 S1305 T1349 K1353 N1374 D1394 Y1524 Q1552 S1258 S1260 T1304 K1308 N1329 D1349 Y1479 Q1507 R137 K159 E201 K257 E267 R271 N275 H278 H282 H294 R123 K145 E187 K243 E253 R257 N261 H264 H268 H280 1.1.1.25,2.5.1.19,2.7.1.71,4.2.1.10,4.2.3.4 0003824,0003855,0003856,0003866,0004764,0004765,0005524,0005737,0008652,0009073,0009423,0016301,0016310,0016491,0016765,0016829,0046872 G0S061 32632294 1606 EPTRIAILGKEDIIVDHGIWLNFVAHDLLQTLPSSTYVLITDTNLYTTYVPPFQAVFEAAAPRDVRLLTYAIPPGEYSKSRETKAEIEDWMLSHACTRDTVIIALGGGVIGDMIGYVAATFMRGVRFVQVPTTLLAMVDSSIGGKTAIDTPMGKNLIGAFWQPRRIYIDLAFLETLPVREFINGMAEVIKTAAIWNETEFTALEENAAAILEAVRSKASSPAARLAPIRHILKRIVLGSARVKAEVVSADEREGGLRNLLNFGHSIGHAYEAILAPQVLHGECVAIGMVKEAELARYLGVLRPSAVARLTKLIASYDLPTSVHDKRIAKLSAGKECPVDVLLQKMAVDKKNEGRKKKIVLLSAIGKTYEKKATVVDDRAIRLVLSPSVRVTPGVPKGLSVTVTPPGSKSISNRALVLAALGEGTTRIHGLLHSDDVQYMLAAIEQLHGADFSWEDAGEILVVTGKGGKLQASKEPLYLGNAGTASRFLTSVVALCAPSAVSSTVLTGNARMKVRPIGALVDALRANGVGVKYLEKEKSLPVEVDAAGGFAGGVIELAATVSSQYVSSILMAAPYAHQPVTLRLVGGKPISQPYIDMTIAMMASFGIKVERSAEDPNTYLIPKGVYKNPPEYVVESDASSATYPLAVAAITGTTCTIPNIGSESLQGDARFAVEVLRPMGCAVEQTATSTTVTGPPIGTLKAIPHVDMEPMTDAFLTAAVLAAVADGTTQITGIANQRVKECNRIAAMKDQLAKFGVQCNELEDGIEVIGKPYQELRNPVEGIYCYDDHRVAMSHSVLSTISPHPVLILERECTAKTWPGWWDILSQFFKVQLDGEEDPTGTDRSIFIVGMRGAGKSTAGRWMSELLKRPLVDLDAELERREGMTIPEIIRGERGWEGFRQAELELLQDVIKNQSKGYIFSCGGGIVETEAARKLLIDYHKNGGPVLLVHRDNIREVYERRKPWFYECSNLQYHSPHEDGSEALLQPPADFARFVKLIAGQSTHLEDVRAKKHSFFVSLTVPNVADALDIIPRVVVGSDAVELRVDLLESYEPEFVARQVALLRAAAQVPIVYTVRTQSQGGKFPDEDYDLALRLYQTGLRSGVEYLDLEMTMPDHILQAVTDAKGFTSIIASHHDPQCKLSWKSGSWIPFYNKALQYGDVIKLVGVAREMADNFALTNFKAKMLAAHDNKPMIALNMGTAGKLSRVLNGFLTPVSHPALPSKAAPGQLSATEIRQALSLIGEIEPKSFYLFGKPISASRSPALHNTLFYKTGLPHHYSRFETDEASKALESLIRSPDFGGASVTIPLKLDIMPLLDSATDAARTIGAVNTIIPQTRDGSTTTLVGDNTDWRGMVHALLHSSGSGSVVQRTAAPRGAAMVVGSGGTARAAIYALHDLGFAPIWIVARSEERVAELVRGFDGYDLRRMTSPHQGKDNMPSVVISTIPATQPIDPSMREVIVEVLKHGHPSAEGKVLLEMAYQPPRTPLMTLAEDQGWRTVGGLEVLAAQGWYQFQLWTGITPLYEEARAAVMGEDSVE 6hqv B 3.0 BS06 SKM B 2 D900 G949 G950 R1005 D874 G923 G924 R960 R137 K159 E201 K257 E267 R271 N275 H278 H282 H294 R123 K145 E187 K243 E253 R257 N261 H264 H268 H280 1.1.1.25,2.5.1.19,2.7.1.71,4.2.1.10,4.2.3.4 0003824,0003855,0003856,0003866,0004764,0004765,0005524,0005737,0008652,0009073,0009423,0016301,0016310,0016491,0016765,0016829,0046872 G0S061 32632294 1607 EPTRIAILGKEDIIVDHGIWLNFVAHDLLQTLPSSTYVLITDTNLYTTYVPPFQAVFEAAAPRDVRLLTYAIPPGEYSKSRETKAEIEDWMLSHACTRDTVIIALGGGVIGDMIGYVAATFMRGVRFVQVPTTLLAMVDSSIGGKTAIDTPMGKNLIGAFWQPRRIYIDLAFLETLPVREFINGMAEVIKTAAIWNETEFTALEENAAAILEAVRSKASSPAARLAPIRHILKRIVLGSARVKAEVVSADEREGGLRNLLNFGHSIGHAYEAILAPQVLHGECVAIGMVKEAELARYLGVLRPSAVARLTKLIASYDLPTSVHDKRIAKLSAGKECPVDVLLQKMAVDKKNEGRKKKIVLLSAIGKTYEKKATVVDDRAIRLVLSPSVRVTPGVPKGLSVTVTPPGSKSISNRALVLAALGEGTTRIHGLLHSDDVQYMLAAIEQLHGADFSWEDAGEILVVTGKGGKLQASKEPLYLGNAGTASRFLTSVVALCAPSAVSSTVLTGNARMKVRPIGALVDALRANGVGVKYLEKEKSLPVEVDAAGGFAGGVIELAATVSSQYVSSILMAAPYAHQPVTLRLVGGKPISQPYIDMTIAMMASFGIKVERSAEDPNTYLIPKGVYKNPPEYVVESDASSATYPLAVAAITGTTCTIPNIGSESLQGDARFAVEVLRPMGCAVEQTATSTTVTGPPIGTLKAIPHVDMEPMTDAFLTAAVLAAVADGTTQITGIANQRVKECNRIAAMKDQLAKFGVQCNELEDGIEVIGKPYQELRNPVEGIYCYDDHRVAMSHSVLSTISPHPVLILERECTAKTWPGWWDILSQFFKVQLDGEEDPTGTDRSIFIVGMRGAGKSTAGRWMSELLKRPLVDLDAELERREGMTIPEIIRGERGWEGFRQAELELLQDVIKNQSKGYIFSCGGGIVETEAARKLLIDYHKNGGPVLLVHRDNIREVYERRKPWFYECSNLQYHSPHEDGSEALLQPPADFARFVKLIAGQSTHLEDVRAKKHSFFVSLTVPNVADALDIIPRVVVGSDAVELRVDLLESYEPEFVARQVALLRAAAQVPIVYTVRTQSQGGKFPDEDYDLALRLYQTGLRSGVEYLDLEMTMPDHILQAVTDAKGFTSIIASHHDPQCKLSWKSGSWIPFYNKALQYGDVIKLVGVAREMADNFALTNFKAKMLAAHDNKPMIALNMGTAGKLSRVLNGFLTPVSHPALPSKAAPGQLSATEIRQALSLIGEIEPKSFYLFGKPISASRSPALHNTLFYKTGLPHHYSRFETDEASKALESLIRSPDFGGASVTIPLKLDIMPLLDSATDAARTIGAVNTIIPQTRDGSTTTLVGDNTDWRGMVHALLHSSGSGSVVQRTAAPRGAAMVVGSGGTARAAIYALHDLGFAPIWIVARSEERVAELVRGFDGYDLRRMTSPHQGKDNMPSVVISTIPATQPIDPSMREVIVEVLKHGHPSAEGKVLLEMAYQPPRTPLMTLAEDQGWRTVGGLEVLAAQGWYQFQLWTGITPLYEEARAAVMGEDSVE 6hqv B 3.0 BS07 SKM B 3 R427 S576 Q577 R413 S562 Q563 R137 K159 E201 K257 E267 R271 N275 H278 H282 H294 R123 K145 E187 K243 E253 R257 N261 H264 H268 H280 1.1.1.25,2.5.1.19,2.7.1.71,4.2.1.10,4.2.3.4 0003824,0003855,0003856,0003866,0004764,0004765,0005524,0005737,0008652,0009073,0009423,0016301,0016310,0016491,0016765,0016829,0046872 G0S061 32632294 1608 EPTRIAILGKEDIIVDHGIWLNFVAHDLLQTLPSSTYVLITDTNLYTTYVPPFQAVFEAAAPRDVRLLTYAIPPGEYSKSRETKAEIEDWMLSHACTRDTVIIALGGGVIGDMIGYVAATFMRGVRFVQVPTTLLAMVDSSIGGKTAIDTPMGKNLIGAFWQPRRIYIDLAFLETLPVREFINGMAEVIKTAAIWNETEFTALEENAAAILEAVRSKASSPAARLAPIRHILKRIVLGSARVKAEVVSADEREGGLRNLLNFGHSIGHAYEAILAPQVLHGECVAIGMVKEAELARYLGVLRPSAVARLTKLIASYDLPTSVHDKRIAKLSAGKECPVDVLLQKMAVDKKNEGRKKKIVLLSAIGKTYEKKATVVDDRAIRLVLSPSVRVTPGVPKGLSVTVTPPGSKSISNRALVLAALGEGTTRIHGLLHSDDVQYMLAAIEQLHGADFSWEDAGEILVVTGKGGKLQASKEPLYLGNAGTASRFLTSVVALCAPSAVSSTVLTGNARMKVRPIGALVDALRANGVGVKYLEKEKSLPVEVDAAGGFAGGVIELAATVSSQYVSSILMAAPYAHQPVTLRLVGGKPISQPYIDMTIAMMASFGIKVERSAEDPNTYLIPKGVYKNPPEYVVESDASSATYPLAVAAITGTTCTIPNIGSESLQGDARFAVEVLRPMGCAVEQTATSTTVTGPPIGTLKAIPHVDMEPMTDAFLTAAVLAAVADGTTQITGIANQRVKECNRIAAMKDQLAKFGVQCNELEDGIEVIGKPYQELRNPVEGIYCYDDHRVAMSHSVLSTISPHPVLILERECTAKTWPGWWDILSQFFKVQLDGEEDPTGTDRSIFIVGMRGAGKSTAGRWMSELLKRPLVDLDAELERREGMTIPEIIRGERGWEGFRQAELELLQDVIKNQSKGYIFSCGGGIVETEAARKLLIDYHKNGGPVLLVHRDNIREVYERRKPWFYECSNLQYHSPHEDGSEALLQPPADFARFVKLIAGQSTHLEDVRAKKHSFFVSLTVPNVADALDIIPRVVVGSDAVELRVDLLESYEPEFVARQVALLRAAAQVPIVYTVRTQSQGGKFPDEDYDLALRLYQTGLRSGVEYLDLEMTMPDHILQAVTDAKGFTSIIASHHDPQCKLSWKSGSWIPFYNKALQYGDVIKLVGVAREMADNFALTNFKAKMLAAHDNKPMIALNMGTAGKLSRVLNGFLTPVSHPALPSKAAPGQLSATEIRQALSLIGEIEPKSFYLFGKPISASRSPALHNTLFYKTGLPHHYSRFETDEASKALESLIRSPDFGGASVTIPLKLDIMPLLDSATDAARTIGAVNTIIPQTRDGSTTTLVGDNTDWRGMVHALLHSSGSGSVVQRTAAPRGAAMVVGSGGTARAAIYALHDLGFAPIWIVARSEERVAELVRGFDGYDLRRMTSPHQGKDNMPSVVISTIPATQPIDPSMREVIVEVLKHGHPSAEGKVLLEMAYQPPRTPLMTLAEDQGWRTVGGLEVLAAQGWYQFQLWTGITPLYEEARAAVMGEDSVE