1aqj A 2.6 BS01 SFG A 1 V21 A47 E71 F90 N105 P106 P107 Y108 F146 V1 A27 E51 F70 N85 P86 P87 Y88 F114 N105 P106 Y108 F196 N85 P86 Y88 F164 2.1.1.72 0003676,0003677,0006304,0008168,0009007,0009307,0032259 -logKd/Ki=6.47, Kd=0.34uM P14385 8995524 500 VETPPEVVDFMVSLAEAPRGGRVLEPACAHGPFLRAFREAHGTGYRFVGVEIDPKALDLPPWAEGILADFLLWEPGEAFDLILGNPPYGIVAVKDLYKKAFSTWKGKYNLYGAFLEKAVRLLKPGGVLVFVVPATWLVLEDFALLREFLAREGKTSVYYLGEVFPQKKVSAVVIRFQKSGKGLSLWDTQESESGFTPILWAEYPHWEGEIIRFETEETRKLEISGMPLGDLFHIRFAARSPEFKKHPAVRKEPGPGLVPVLTGRNLKPGWVDYEKNHSGLWMPKERAKELRDFYATPHLVVAHTKGTRVVAAWDERAYPWREEFHLLPKEGVRLDPSSLVQWLNSEAMQKHVRTLYRDFVPHLTLRMLERLPVRREYGFHT 1aqj B 2.6 BS01 SFG B 1 V21 A47 E71 I72 D89 F90 N105 P106 P107 Y108 V1 A27 E51 I52 D69 F70 N85 P86 P87 Y88 N105 P106 Y108 F196 N85 P86 Y88 F166 2.1.1.72 0003676,0003677,0006304,0008168,0009007,0009307,0032259 P14385 8995524 500 VETPPEVVDFMVSLAEAPRGGRVLEPACAHGPFLRAFREAHGTGYRFVGVEIDPKALDLPPWAEGILADFLLWEPGEAFDLILGNPPYGIVFKAVKDLYKKAFSTWKGKYNLYGAFLEKAVRLLKPGGVLVFVVPATWLVLEDFALLREFLAREGKTSVYYLGEVFPQKKVSAVVIRFQKSGKGLSLWDTQESESGFTPILWAEYPHWEGEIIRFETEETRKLEISGMPLGDLFHIRFAARSPEFKKHPAVRKEPGPGLVPVLTGRNLKPGWVDYEKNHSGLWMPKERAKELRDFYATPHLVVAHTKGTRVVAAWDERAYPWREEFHLLPKEGVRLDPSSLVQWLNSEAMQKHVRTLYRDFVPHLTLRMLERLPVRREYGFHT 1nw6 A 1.94 BS02 SFG A 1 D46 C47 D65 P66 T225 F250 D271 A272 D11 C12 D30 P31 T190 F215 D236 A237 D65 P66 D30 P31 2.1.1.72 0003676,0003677,0008168,0008170,0009007,0009307,0032259 P14751 12732637 401 GTTRHVYDVCDCLDTLAKLPDDSVQLIICDPPYNIMLADWDDHMDYIGWAKRWLAEAERVLSPTGSIAIFGGLQYQGEAGSGDLISIISHMRQNSKMLLANLIIWNYPNGMSAQRFFANRHEEIAWFAKTKKYFFDLDAVREPYDEETKAAYMKDKRLNPESVEKGRNPTNVWRMSRLNGNSLERVGHPTQKPAAVIERLVRALSHPGSTVLDFFAGSGVTARVAIQEGRNSICTDAAPVFKEYYQKQLTFLQRSYEIVEGAANFGAALQR 1qaq A 2.8 BS01 SFG A 1 Q10 N11 F12 I13 G38 S39 G40 E59 I60 L64 D84 I85 N101 P103 I106 Q2 N3 F4 I5 G30 S31 G32 E51 I52 L56 D76 I77 N93 P95 I98 G38 E59 N101 Y104 F163 G30 E51 N93 Y96 F155 2.1.1.184 0000154,0000179,0003723,0005829,0008168,0031167,0032259,0046677,0052910 -logKd/Ki=4.74, Ki=18uM P13956 10366505 245 SQNFITSKHNIDKIMTNIRLNEHDNIFEIGSGKGHFTLELVQRCNFVTAIEIDHKLCKTTENKLVDHDNFQVLNKDILQFKFPKNQSYKIFGNIPYNISTDIIRKIVFDSIADEIYLIVEYGFAKRLLNTKRSLALFLMAEVDISILSMVPREYFHPKPKVNSSLIRLNRKKSRISHKDKQKYNYFVMKWVNKEYKKIFTKNQFNNSLKHAGIDDLNNISFEQFLSLFNSYKLFNK 1xdu A 2.7 BS01 SFG A 1 W146 Y171 G190 G191 E213 L214 D240 F241 F242 S255 F256 N260 W136 Y161 G180 G181 E203 L204 D230 F231 F232 S245 F246 N250 L259 N260 D287 V316 L249 N250 D277 V299 4.1.1.- 0008168,0008171,0016829,0016831,0017000 Q54527 15548527 5635 LEPTDQDLDVLLKNLGNLVTPMALRVAATLRLVDHLLAGADTLAGLADRTDTHPQALSRLVRHLTVVGVLEGGEKGRPLRPTRLGMLLADGHPAQQRAWLDLNGAVSHADLAFTGLLDVVRTGRPAYAGRYGRPFWEDLSADVALADSFDALMSCDEDLAYEAPADAYDWSAVRHVLDVGGGNGGMLAAIALRAPHLRGTLVELAGPAERARRRFADAGLADRVTVAEGDFFKPLPVTADVVLLSFVLLNWSDEDALTILRGCVRALEPGGRLLVLDRADRFFSTLLDLRMLTFMGGRVRTRDEVVDLAGSAGLALASERTSGSTTLPFDFSILEFTAVS 1yfl A 3.09 BS03 SFG A 1 Y7 N10 F32 C33 G34 G35 S37 D50 I51 Q52 H156 F157 D171 P173 Y181 F184 Y7 N10 F32 C33 G34 G35 S37 D50 I51 Q52 H156 F157 D171 P173 Y181 F184 2.1.1.72 0003676,0003677,0006260,0006298,0008168,0009007,0009008,0009307,0019049,0032259,0043565,0052170,0099018,1904047 P04392 15882618 300 MLGAIAYTGNKQSLLPELKSHFPKYNRFVDLFCGGLSVSLNVNGPVLANDIQEPIIEMYKRLINVSWDDVLKVIKQYKLSKTSKEEFLKLREDYNKTRDPLLLYVLHFHGFSNMIRINDKGNFTTPFGKRTINKNSEKRFNHFKQNCDKIIFSSLHFKDVKILDGDFVYVDPPYLITVADYNKFWSEDEEKDLLNLLDSLNDRGIKFGLSNVLEHHGKENTLLKEWSKKYNVKHLNNGTDEVYIFN 1yfl B 3.09 BS03 SFG B 1 Y7 N10 F32 C33 G34 G35 S37 D50 I51 Q52 H156 F157 D171 P173 Y181 F184 Y7 N10 F32 C33 G34 G35 S37 D50 I51 Q52 H156 F157 D171 P173 Y181 F184 2.1.1.72 0003676,0003677,0006260,0006298,0008168,0009007,0009008,0009307,0019049,0032259,0043565,0052170,0099018,1904047 P04392 15882618 301 MLGAIAYTGNKQSLLPELKSHFPKYNRFVDLFCGGLSVSLNVNGPVLANDIQEPIIEMYKRLINVSWDDVLKVIKQYKLSKTSKEEFLKLREDYNKTRDPLLLYVLHFHGFSNMIRINDKGNFTTPFGKRTINKNSEKRFNHFKQNCDKIIFSSLHFKDVKILDGDFVYVDPPYLITVADYNKFWSEDEEKDLLNLLDSLNDRGIKFGLSNVLEHHGKENTLLKEWSKKYNVKHLNNGTDEVYIFN 1yfl D 3.09 BS03 SFG D 1 Y7 N10 F32 C33 G34 G35 D50 I51 D171 Y181 F184 Y7 N10 F32 C33 G34 G35 D50 I51 D171 Y181 F184 2.1.1.72 0003676,0003677,0006260,0006298,0008168,0009007,0009008,0009307,0019049,0032259,0043565,0052170,0099018,1904047 P04392 15882618 302 MLGAIAYTGNKQSLLPELKSHFPKYNRFVDLFCGGLSVSLNVNGPVLANDIQEPIIEMYKRLINVSWDDVLKVIKQYKLSKTSKEEFLKLREDYNKTRDPLLLYVLHFHGFSNMIRINDKGNFTTPFGKRTINKNSEKRFNHFKQNCDKIIFSSLHFKDVKILDGDFVYVDPPYLITVADYNKFWSEDEEKDLLNLLDSLNDRGIKFGLSNVLEHHGKENTLLKEWSKKYNVKHLNKKYNGTDEVYIFN 1yfl E 3.09 BS03 SFG E 1 Y7 N10 F32 C33 G35 S37 D50 I51 D171 Y181 F184 Y7 N10 F32 C33 G35 S37 D50 I51 D171 Y181 F184 2.1.1.72 0003676,0003677,0006260,0006298,0008168,0009007,0009008,0009307,0019049,0032259,0043565,0052170,0099018,1904047 P04392 15882618 303 MLGAIAYTGNKQSLLPELKSHFPKYNRFVDLFCGGLSVSLNVNGPVLANDIQEPIIEMYKRLINVSWDDVLKVIKQYKLSKTSKEEFLKLREDYNKTRDPLLLYVLHFHGFSNMIRINDKGNFTTPFGKRTINKNSEKRFNHFKQNCDKIIFSSLHFKDVKILDGDFVYVDPPYLITVADYNKFWSEDEEKDLLNLLDSLNDRGIKFGLSNVLEHHGKENTLLKEWSKKYNVKHLNKKNGTDEVYIFN 2h2j A 2.45 BS01 SFG A 1 E80 G81 L82 P151 T154 S221 R222 D239 N242 H243 Y287 F302 E31 G32 L33 P102 T105 S172 R173 D187 N190 H191 Y224 F239 Y287 Y224 2.1.1.127,2.1.1.259 0009507,0016279,0018022,0030785 Kd=4.2uM -logKd/Ki=5.38, Kd=4.2uM Q43088 16682405 800 LSPAVQTFWKWLQEEGVITAKTPVKASVVTEGLGLVALKDISRNDVILQVPKRLWINPDAVAASEIGRVCSELKPWLSVILFLIRERSREDSVWKHYFGILPQETDSTIYWSEEELQELQGSQLLKTTVSVKEYVKNECLKLEQEIILPNKRLFPDPVTLDDFFWAFGILRSRAFSRLNLVVVPMADLINHSAGVTTEDHAYEYLFSLKSPLSVKAGEQVYIQYDLNKSNAELALDYGFIEPNENRHAYTLTLEISESDPFFDDKLDVAESNGFAQTAYFDIFYNRTLPPGLLPYLRLVALGGTDAFLLESLFRDTIWGHLELSVSRDNEELLCKAVREACKSALAGYHTTIEQDRELKEGNLDSRLAIAVGIREGEKMVLQQIDGIFEQKELELDQLEYYQERRLKDLGLCGENGDILENLY 2h2j B 2.45 BS01 SFG B 1 E80 G81 L82 S221 R222 D239 N242 H243 Y287 F302 E32 G33 L34 S173 R174 D191 N194 H195 Y239 F254 Y287 Y239 2.1.1.127,2.1.1.259 0009507,0016279,0018022,0030785 Kd=4.2uM Q43088 16682405 801 SLSPAVQTFWKWLQEEGVITAKTPVKASVVTEGLGLVALKDISRNDVILQVPKRLWINPDAVAASEIGRVCSELKPWLSVILFLIRERSREDSVWKHYFGILPQETDSTIYWSEEELQELQGSQLLKTTVSVKEYVKNECLKLEQEIILPNKRLFPDPVTLDDFFWAFGILRSRAFSRLRNENLVVVPMADLINHSAGVTTEDHAYEVKGAAGLFSWDYLFSLKSPLSVKAGEQVYIQYDLNKSNAELALDYGFIEPNENRHAYTLTLEISESDPFFDDKLDVAESNGFAQTAYFDIFYNRTLPPGLLPYLRLVALGGTDAFLLESLFRDTIWGHLELSVSRDNEELLCKAVREACKSALAGYHTTIEQDRELKEGNLDSRLAIAVGIREGEKMVLQQIDGIFEQKELELDQLEYYQERRLKDLGLCGENGDILENLYF 2h2j C 2.45 BS01 SFG C 1 E80 G81 L82 T154 S221 R222 D239 N242 H243 Y287 F302 E31 G32 L33 T105 S172 R173 D190 N193 H194 Y238 F253 Y287 Y238 2.1.1.127,2.1.1.259 0009507,0016279,0018022,0030785 Kd=4.2uM Q43088 16682405 802 LSPAVQTFWKWLQEEGVITAKTPVKASVVTEGLGLVALKDISRNDVILQVPKRLWINPDAVAASEIGRVCSELKPWLSVILFLIRERSREDSVWKHYFGILPQETDSTIYWSEEELQELQGSQLLKTTVSVKEYVKNECLKLEQEIILPNKRLFPDPVTLDDFFWAFGILRSRAFSRLRNENLVVVPMADLINHSAGVTTEDHAYEVKGAAGLFSWDYLFSLKSPLSVKAGEQVYIQYDLNKSNAELALDYGFIEPNENRHAYTLTLEISESDPFFDDKLDVAESNGFAQTAYFDIFYNRTLPPGLLPYLRLVALGGTDAFLLESLFRDTIWGHLELSVSRDNEELLCKAVREACKSALAGYHTTIEQDRELKEGNLDSRLAIAVGIREGEKMVLQQIDGIFEQKELELDQLEYYQERRLKDLGLCGENGDILENLYF 2hv9 A 2.6 BS01 SFG A 1 K54 G72 D94 I95 A96 D122 S123 Y124 Q140 F141 S142 Y145 K14 G32 D54 I55 A56 D82 S83 Y84 Q100 F101 S102 Y105 2.1.1.56 0003723,0004482,0005634,0006370,0008168,0032259,0106005 Q8SR66 16971388 299 SKTINIRNANNFIKACLIRLYTKRGDSVLDLGCGKGGDLLKYERAGIGEYYGVDIAEVSINDARVRARNMKRRFKVFFRAQDSYGRHMDLGKEFDVISSQFSFHYAFSTSESLDIAQRNIARHLRPGGYFIMTVPSRDVILERYKQGRMSNDFYKIELEKMVPMESVREYRFTLLDSVNNCIEYFVDFTRMVDGFKRLGLSLVERKGFIDFYEDEGRRNPELSKKLGCLTREESEVVGIYEVVVFRKL 2xva A 1.9 BS01 SFG A 1 G38 R43 N44 D59 K60 D86 L87 T102 V103 V104 L108 G40 R45 N46 D61 K62 D88 L89 T104 V105 V106 L110 2.1.1.265 0005737,0005829,0008168,0008757,0009636,0032259,0046677,0046690 P25397 21244361 1198 GAMVIRDENYFTDKYELTRTHSEVLEAVKVVKPGKTLDLGCGNGRNSLYLAANGYDVDAWDKNAMSIANVERIKSIENLDNLHTRVVDLNNLTFDRQYDFILSTVVLMFLEAKTIPGLIANMQRCTKPGGYNLIVAAMDTADYPCTVGFPFAFKEGELRRYYEGWERVKYNEDVGELHRTDANGNRIKLRFATMLARKK 2xva B 1.9 BS01 SFG B 1 G38 R43 D59 K60 V85 D86 L87 T102 V103 V104 L108 G40 R45 D61 K62 V87 D88 L89 T104 V105 V106 L110 2.1.1.265 0005737,0005829,0008168,0008757,0009636,0032259,0046677,0046690 P25397 21244361 1198 GAMVIRDENYFTDKYELTRTHSEVLEAVKVVKPGKTLDLGCGNGRNSLYLAANGYDVDAWDKNAMSIANVERIKSIENLDNLHTRVVDLNNLTFDRQYDFILSTVVLMFLEAKTIPGLIANMQRCTKPGGYNLIVAAMDTADYPCTVGFPFAFKEGELRRYYEGWERVKYNEDVGELHRTDANGNRIKLRFATMLARKK 2xva C 1.9 BS01 SFG C 1 G38 G40 R43 N44 D59 K60 D86 L87 T102 V103 V104 L108 G35 G37 R40 N41 D56 K57 D83 L84 T99 V100 V101 L105 2.1.1.265 0005737,0005829,0008168,0008757,0009636,0032259,0046677,0046690 P25397 21244361 1197 RDENYFTDKYELTRTHSEVLEAVKVVKPGKTLDLGCGNGRNSLYLAANGYDVDAWDKNAMSIANVERIKSIENLDNLHTRVVDLNNLTFDRQYDFILSTVVLMFLEAKTIPGLIANMQRCTKPGGYNLIVAAMDTADYPCTVGFPFAFKEGELRRYYEGWERVKYNEDVGELHRTDNRIKLRFATMLARK 2xva D 1.9 BS01 SFG D 1 G38 R43 D59 K60 D86 L87 T102 V103 V104 L108 G35 R40 D56 K57 D83 L84 T99 V100 V101 L105 2.1.1.265 0005737,0005829,0008168,0008757,0009636,0032259,0046677,0046690 P25397 21244361 1198 RDENYFTDKYELTRTHSEVLEAVKVVKPGKTLDLGCGNGRNSLYLAANGYDVDAWDKNAMSIANVERIKSIENLDNLHTRVVDLNNLTFDRQYDFILSTVVLMFLEAKTIPGLIANMQRCTKPGGYNLIVAAMDTADYPCTVGFPFAFKEGELRRYYEGWERVKYNEDVGELHRTDANGNRIKLRFATMLARKK 2xyr A 2.5 BS01 SFG A 1 N43 G71 G73 P80 G81 D99 L100 C115 D130 M131 Y132 N41 G69 G71 P78 G79 D97 L98 C113 D128 M129 Y130 2.1.1.-,2.1.1.56,2.1.1.57,2.7.7.48,2.7.7.50,3.1.13.-,3.4.19.12,3.4.22.-,3.4.22.69,3.6.4.12,3.6.4.13,4.6.1.- 0004483 -logKd/Ki=6.13, IC50=0.74uM P0C6X7 21637813 1298 QAWQPGVAMPNLYKMQRMLLEKCDLQNYGENAVIPKGIMMNVAKYTQLCQYLNTLTLAVPYNMRVIHFGAGSDKGVAPGTAVLRQWLPTGTLLVDSDLNDFVSDADSTLIGDCATVHTANKWDLIISDMYDPRTKENDSKEGFFTYLCGFIKQKLALGGSIAVKITEHSWNADLYKLMGHFSWWTAFVTNVNASSSEAFLIGANYLGKPKEQIDGYTMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLRGTAVMSLKENQINDMIYSLLEKGRLIIRENNRVVVSS 2y1w A 2.1 BS01 SFG A 1 F151 Y154 M163 R169 G193 C194 G195 I198 L199 E215 A216 K242 E244 E258 M269 F16 Y19 M28 R34 G58 C59 G60 I63 L64 E80 A81 K107 E109 E123 M134 D166 E258 E267 H415 D31 E123 E132 H280 2.1.1.319 0016274,0018216 Q86X55 21410432 1001 SVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYT 2y1w B 2.1 BS01 SFG B 1 Y150 F151 Y154 M163 R169 G193 C194 I198 L199 E215 A216 K242 E244 E258 M269 Y15 F16 Y19 M28 R34 G58 C59 I63 L64 E80 A81 K107 E109 E123 M134 D166 E258 E267 H415 D31 E123 E132 H280 2.1.1.319 0016274,0018216 Q86X55 21410432 1001 SVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYT 2y1w C 2.1 BS01 SFG C 1 Y150 F151 Y154 M163 R169 G193 C194 I198 E215 A216 K242 E244 E258 M269 Y15 F16 Y19 M28 R34 G58 C59 I63 E80 A81 K107 E109 E123 M134 D166 E258 E267 H415 D31 E123 E132 H280 2.1.1.319 0016274,0018216 Q86X55 21410432 1001 SVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYT 2y1w D 2.1 BS01 SFG D 1 F151 Y154 Q160 M163 R169 G193 C194 I198 L199 E215 A216 K242 V243 E244 E258 M269 S272 F16 Y19 Q25 M28 R34 G58 C59 I63 L64 E80 A81 K107 V108 E109 E123 M134 S137 D166 E258 E267 H415 D31 E123 E132 H280 2.1.1.319 0016274,0018216 Q86X55 21410432 1001 SVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYT 2yx1 A 2.2 BS03 SFG A 1 R186 F203 A204 P208 F209 D223 I224 D251 V252 N265 L266 R173 F190 A191 P195 F196 D210 I211 D238 V239 N252 L253 2.1.1.228 0002939,0005737,0008033,0008168,0008175,0016740,0030488,0032259,0052906 Q58293 18384044 401 PLCLKINKKHGEQTRRILIENNLLNKDYKITSEGNYLYLPIKDVDEDILKSILNIEFELVDKELEEKPSFREIISKKYRKEIDEGLISLSYDVVGDLVILQISDEVDEKIRKEIGELAYKLIPCKGVFRRKRVRELEHLAGENRTLTIHKENGYRLWVDIAKVYFSPRLGGERARIMKKVSLNDVVVDMFAGVGPFSIACKNAKKIYAIDINPHAIELLKKNIKLNKLEHKIIPILSDVREVDVKGNRVIMNLPKFAHKFIDKALDIVEEGGVIHYYTIGKDFDKAIKLFEKKCDCEVLEKRIVKSYAPREYILALDFKINKK 2yx1 B 2.2 BS04 SFG B 1 R186 F203 A204 P208 F209 D223 I224 D251 V252 N265 L266 R160 F177 A178 P182 F183 D197 I198 D225 V226 N239 L240 2.1.1.228 0002939,0005737,0008033,0008168,0008175,0016740,0030488,0032259,0052906 Q58293 18384044 402 PLCLKINKKHGEQTRRILIENNLLNKDYKITSEGNYLYLPIKDVDEDILKSILNIEFELVDKELEEKFREIIGLISLSYDVVGDLVILQISDEVDEKIRKEIGELAYKLIPCKGVFRRKVRELEHLAGENRTLTIHKENGYRLWVDIAKVYFSPRLGGERARIMKKVSLNDVVVDMFAGVGPFSIACKNAKKIYAIDINPHAIELLKKNIKLNKLEHKIIPILSDVREVDVKGNRVIMNLPKFAHKFIDKALDIVEEGGVIHYYTIGKDFDKAIKLFEKKCDCEVLEKRIVKSYAPREYILALDFKINKK 2yxl A 2.55 BS01 SFG A 1 A267 A268 A269 P270 G271 G272 K273 D291 V292 R296 A319 D337 P339 A262 A263 A264 P265 G266 G267 K268 D286 V287 R291 A314 D332 P334 ? 0001510,0003723,0006396,0008168,0008173,0008757,0016428,0016740,0030488,0032259 O58581 21123870 5748 KKLSIPPKGIRAIIEAIRLGEIIKPSQYAKREAFKKHDVEEAWLNRVLTMIFYDIMKKQGLIDKVIKEIVGVTPLILDPWLRAALRVAVDIALFHDPSSQTIKNLRWKASDFISSRTHPYVGMYFWDLLDKIFEYKPNPKNELEELEWKYLAPSWLIERVKGILGDETEDFFRSVNKRHEWISIRVNTLKANVEEVIGELEEDGVEVVRSERVPTILKIKGPYNFDTSSAFNEGKIIVQEEASAVASIVLDPKPGETVVDLAAAPGGKTTHLAELMKNKGKIYAFDVDKMRMKRLKDFVKRMGIKIVKPLVKDARKAPEIIGEEVADKVLLDAPCTSSGTIGKNPELRWRLREDKINEMSQLQRELLESAARLVKPGGRLLYTTCSIFKEENEKNIRWFLNVHPEFKLVPLKSPYDPGFLEGTMRAWPHRHSTIGFFYALLEK 2zbr A 1.9 BS01 SFG A 1 T107 G128 L134 D149 I150 S175 N191 T101 G122 L128 D143 I144 S169 N185 2.1.1.- 0005515,0005737,0006338,0006479,0008168,0008276,0032259,0042054 Q84BQ9 300 MWVYRLKGTLEALDPILPGLFDGGARGLWEREGEVWAFFPAPVDLPYEGVWEEVGDEDWLEAWRRDLKPALAPPFVVLAPWHTWEGAEIPLVIEPGHHETTRLALKALARHLRPGDKVLDLGTGSGVLAIAAEKLGGKALGVDIDPMVLPQAEANAKRNGVRPRFLEGSLEAALPFGPFDLLVANLYAELHAALAPRYREALVPGGRALLTGILKDRAPLVREAMAGAGFRPLEEAAEGEWVLLAYGR 3a4t A 2.3 BS01 SFG A 1 C91 A92 A93 G96 K97 E115 I116 R120 M143 D163 P165 N169 R189 C83 A84 A85 G88 K89 E107 I108 R112 M135 D155 P157 N161 R173 2.1.1.- 0001510,0003723,0005737,0006396,0008033,0008168,0008173,0008757,0016428,0016740,0030488,0032259 Q60343 20600111 500 KMQFIRVNTLKINPEVLKKRLENKGVVLEKTFLDYAFEVKKSPFSIGSTPEYLFGYYMPQSISSMIPPIVLNPREDDFILDMCAAPGGKTTHLAQLMKNKGTIVAVEISKTRTKALKSNINRMGVLNTIIINADMRKYKDYLLKNEIFFDKILLDAPCSGNISEEDIKYCSLRQKELIDIGIDLLKKDGELVYSTCSMEVEENEEVIKYILQKRNDVELIIIKANEFKGINIKEGYIKGTLRVFPPNEPFFIAKLRKI 3a4t B 2.3 BS01 SFG B 1 C91 A92 A93 P94 G96 K97 E115 I116 R120 M143 D163 P165 R189 C82 A83 A84 P85 G87 K88 E106 I107 R111 M134 D154 P156 R168 2.1.1.- 0001510,0003723,0005737,0006396,0008033,0008168,0008173,0008757,0016428,0016740,0030488,0032259 Q60343 20600111 501 MQFIRVNTLKINPEVLKKRLENKGVVLEKTFLDYAFEVKKSPFSIGSTPEYLFGYYMPQSISSMIPPIVLNPREDDFILDMCAAPGGKTTHLAQLMKNKGTIVAVEISKTRTKALKSNINRMGVLNTIIINADMRKYKDYLLKNEIFFDKILLDAPCSGNDIKYCSLRQKELIDIGIDLLKKDGELVYSTCSMEVEENEEVIKYILQKRNDVELIIIKANEFKGINIKEGYIKGTLRVFPPNEPFFIAKLRKI 3axs A 2.162 BS02 SFG A 1 R36 L60 A62 I65 R66 D84 I85 E113 A114 D132 F134 R36 L60 A62 I65 R66 D84 I85 E113 A114 D132 F134 2.1.1.215 0000049,0002940,0003723,0006400,0008033,0008168,0016423,0030488,0032259,0160103,0160104 O67010 21844194 501 MEIVQEGIAKIIVPEIPKTVSSDMPVFYNPRMRVNRDLAVLGLEYLCKKLGRPVKVADPLSASGIRAIRFLLETSCVEKAYANDISSKAIEIMKENFKLNNIPEDRYEIHGMEANFFLRKEWGFGFDYVDLDPFGTPVPFIESVALSMKRGGILSLTATDTAPLSGTYPKTCMRRYMARPLRNEFKHEVGIRILIKKVIELAAQYDIAMIPIFAYSHLHYFKLFFVKERGVEKVDKLIEQFGYIQYCFNCMNREVVTDLYKFKEKCPHCGSKFHIGGPLWIGKLWDEEFTNFLYEEAQKREEIEKETKRILKLIKEESQLQTVGFYVLSKLAEKVKLPAQPPIRIAVKFFNGVRTHFVGDGFRTNLSFEEVMKKMEELKEKQKEFLE 3bbh A 2.25 BS01 SFG A 1 M141 T142 K143 G162 F164 S184 I185 Y186 G189 L190 V195 M140 T141 K142 G161 F163 S183 I184 Y185 G188 L189 V194 2.1.1.- 0006364,0008168,0019843,0032259,0042254,0042803,0070037,0070475 Q57977 18208838 206 TYNIILAKSALELIPEEIKNKIRKSRVYKYDILDSNYHYKAMEKLKDKEMRGRPDIIHISLLNILDSPINHEKKLNIYIHTYDDKVLKINPETRLPRNYFRFLGVMEKVLKGERNHLIKMEEKTLEDLLNEINAKKIAIMTKTGKLTHPKLLKEYDTFIIGGFPYGKLKINKEKVFGDIKEISIYNKGLMAWTVCGIICYSLSF 3bbh B 2.25 BS01 SFG B 1 M141 T142 K143 G162 F164 S184 I185 Y186 K188 G189 L190 V195 M140 T141 K142 G161 F163 S183 I184 Y185 K187 G188 L189 V194 2.1.1.- 0006364,0008168,0019843,0032259,0042254,0042803,0070037,0070475 Q57977 18208838 206 TYNIILAKSALELIPEEIKNKIRKSRVYKYDILDSNYHYKAMEKLKDKEMRGRPDIIHISLLNILDSPINHEKKLNIYIHTYDDKVLKINPETRLPRNYFRFLGVMEKVLKGERNHLIKMEEKTLEDLLNEINAKKIAIMTKTGKLTHPKLLKEYDTFIIGGFPYGKLKINKEKVFGDIKEISIYNKGLMAWTVCGIICYSLSF 3cbp A 1.42 BS02 SFG A 1 A226 E228 G264 N265 H293 K294 N296 H297 Y335 W352 E356 A110 E112 G148 N149 H177 K178 N180 H181 Y219 W228 E232 Y245 H293 H297 Y305 Y335 Y129 H177 H181 Y189 Y219 2.1.1.364 0005694,0006355,0016279,0140945 -logKd/Ki=5.60, IC50=2.5uM IC50=2500nM Q8WTS6 18471979 1501 GVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLATLMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFTPNCIYDMFVHPRFGPIKCIRTLRAVEADEELTVAYGYDHEAPEWYQVELKAFQAT 3cjr A 2.05 BS01 SFG A 1 F99 T107 G128 T129 L134 D149 I150 S175 N191 F94 T102 G123 T124 L129 D144 I145 S170 N186 2.1.1.- 0005515,0005737,0006338,0006479,0008168,0008276,0032259,0042054 Q84BQ9 18611379 255 MWVYRLKGTLEALDPILPGLFDGGARGLWEREGEVWAFFPAPVDLPYEGVWEEVLEAWRRDLKPALAPPFVVLAPWHTWEGAEIPLVIEPGMAFGTGHHETTRLALKALARHLRPGDKVLDLGTGSGVLAIAAEKLGGKALGVDIDPMVLPQAEANAKRNGVRPRFLEGSLEAALPFGPFDLLVANLYAELHAALAPRYREALVPGGRALLTGILKDRAPLVREAMAGAGFRPLEEAAEGEWVLLAYGR 3eld A 1.9 BS01 SFG A 1 S56 G81 G86 W87 T104 L105 H110 S130 N131 V132 F133 D146 I147 S51 G76 G81 W82 T99 L100 H105 S125 N126 V127 F128 D141 I142 2.1.1.57 0000166,0004482,0004483,0006370,0008168,0032259,0106005 D0VX01 18976670 293 VTLGEVWKRQLNMLGKQEFERYKVSDITEVDRTAARRYLKEGRTDVGISVSRGAAKIRWLHERGYLRITGRVLDLGCGRGGWSYYAAAQKEVMSVKGYTLGIEGHEKPIHMQTLGWNIVKFKDKSNVFTMPTEPSDTLLCDIGESSSNPLVERDRTMKVLENFERWKHVNTENFCVKVLAPYHPDVIEKLERLQLRFGGGIVRVPFSRNSTHEMYYISGARNNITHMVNTTSRSLLRRMTRPSGKAIIEGDVFLPTGTRSVAGTIDHEALKLRVDQI 3emd A 2.0 BS01 SFG A 1 S56 G58 G81 G86 W87 T104 L105 E111 S130 N131 V132 F133 D146 I147 S51 G53 G76 G81 W82 T99 L100 E106 S125 N126 V127 F128 D141 I142 2.1.1.57 0000166,0004482,0004483,0006370,0008168,0032259,0106005 D0VX01 18976670 293 VTLGEVWKRQLNMLGKQEFERYKVSDITEVDRTAARRYLKEGRTDVGISVSRGAAKIRWLHERGYLRITGRVLDLGCGRGGWSYYAAAQKEVMSVKGYTLGIEGHEKPIHMQTLGWNIVKFKDKSNVFTMPTEPSDTLLCDIGESSSNPLVERDRTMKVLENFERWKHVNTENFCVKVLAPYHPDVIEKLERLQLRFGGGIVRVPFSRNSTHEMYYISGARNNITHMVNTTSRSLLRRMTRPSGKAIIEGDVFLPTGTR 3epp A 2.41 BS01 SFG A 1 K17 G42 D64 I65 S100 Q121 F122 V123 Y126 M137 K12 G35 D57 I58 S91 Q112 F113 V114 Y117 M128 2.1.1.56 0004482,0006370 O43148 401 IFYLRNFNNWMKSVLIGEFLEKVRQKKDITVLDLGCGKGGDLLKWKKGRINKLVCTDIADVSVKQCQQRYEDMKNRSEYIFSAEFITADSSKELLIDKFRDPQMCFDICSCQFVCHYSFESYEQADMMLRNACERLSPGGYFIGTTPNSFELIRRLEASETESFGNEIYTVKFQKKGDYPLFGCKYDFNDVPEFLVYFPLLNEMAKKYNMKLVYKKTFLEFYEEKIKNNENKMLLKRMQLPLGTLSKSEWEATSIYLVFAFEKQQ 3epp B 2.41 BS01 SFG B 1 K17 G42 D64 I65 D98 S99 Q121 F122 V123 M137 K13 G38 D60 I61 D90 S91 Q113 F114 V115 M129 2.1.1.56 0004482,0006370 O43148 401 RIFYLRNFNNWMKSVLIGEFLEKVRQKKKRDITVLDLGCGKGGDLLKWKKGRINKLVCTDIADVSVKQCQQRYEDMKNRYIFSAEFITADSSKELLIDKFRDPQMCFDICSCQFVCHYSFESYEQADMMLRNACERLSPGGYFIGTTPNSFELIRRLEASETESFGNEIYTVKFQKKGDYPLFGCKYDFNLEDVPEFLVYFPLLNEMAKKYNMKLVYKKTFLEFYEEKIKNNENKMLLKRMQLPLGTLSKSEWEATSIYLVFAFEKQQ 3g2q A 2.18 BS01 SFG A 1 A71 A72 R76 E92 L93 D122 M123 A54 A55 R59 E75 L76 D105 M106 ? O52805 19389626 400 GPVRTPHADVLLASVGERGVLCDFYDEGAAADGTSEAREFATRTGVSGPVLELAAGMGRLTFPFLDLGWEVTALELSTSVLAAFRKRLAEAPADVRDRCTLVQGDMSAFALDKRFGTVVISSGSINELDEADRRGLYASVREHLEPGGKFLLSLAMSEAAESEPLERKQVLHVRHLPAEEIQEITIHPADETTDPFVVCTHRRRLLAPDQVVRELVRSGFDVIAQTPFASGGAGRKDMVLVEAVMPG 3g2q B 2.18 BS01 SFG B 1 A71 R76 E92 L93 D122 M123 A37 R42 E58 L59 D88 M89 ? O52805 19389626 500 GPVRTPHACDFYADGTSEAREFATRTGPVSGPVLELAAGMGRLTFPFLDLGWEVTALELSTSVLAAFRKRLAEAPADVRDRCTLVQGDMSAFALDKRFGTVVISSGSINELDEADRRGLYASVREHLEPGGKFLLSLAMSEAAESEPLERKQELPGGRRYVLHVRHLPAEEIQEITIHPADVCTHRRRLLAPDQVVRELVRSGFDVIAQTPFASGGAGRKDMVLVEAVMP 3ha5 A 2.3 BS01 SFG A 1 S43 G81 L104 G131 W132 E133 I145 E146 A147 H150 F151 S23 G61 L84 G111 W112 E113 I125 E126 A127 H130 F131 2.1.1.- 0005515,0005886,0006629,0008168,0008610,0008757,0009274,0032259,0071768 Q79FX8 302 IQAHYDVSDDFFALFQDPTRTYSCAYFEPPELTLEEAQYAKVDLNLDKLDLKPGMTLLDIGCGWGTTMRRAVERFDVNVIGLTLSKNQHARCEQVLASIDTNRSRQVLLQGWEDFAEPVDRIVSIEAFEHFGHENYDDFFKRCFNIMPADGRMTVQSSVSYHPYEMAARGKKLSFETARFIKFIVTEIFPGGRLPSTEMMVEHGEKAGFTVPEPLSLRPHYIKTLRIWGDTLQSNKDKAIEVTSEEVYNRYMKYLRGCEHYFTDEMLDCSLVTYLKPGAAA 3lkz A 2.0 BS01 SFG A 1 S56 G58 G81 G86 W87 K105 H110 E111 D131 V132 F133 D146 I147 S52 G54 G77 G82 W83 K101 H106 E107 D127 V128 F129 D142 I143 2.1.1.56,2.1.1.57,2.7.7.48,3.4.21.91,3.6.1.15,3.6.4.13 0003968,0004482,0004483,0005524,0008168,0032259 -logKd/Ki=6.15, IC50=0.7uM Q9Q6P4 20685660 301 GRTLGEVWKERLNQMTKEEFTRYRKEAIIEVDRSAAKHARKEGNVTGGHPVSRGTAKLRWLVERRFLEPVGKVIDLGCGRGGWCYYMATQKRVQEVRGYTKGGPGHEEPQLVQSYGWNIVTMKSGVDVFYRPSECCDTLLCDIGESSSSAEVEEHRTIRVLEMVEDWLHRGPREFCVKVLCPYMPKVIEKMELLQRRYGGGLVRNPLSRNSTHEMYWVSRASGNVVHSVNMTSQVLLGRMEKRTWKGPQYEEDVNLGSGTRA 3lkz B 2.0 BS01 SFG B 1 S56 G58 G81 G86 W87 T104 K105 H110 E111 D131 V132 F133 D146 I147 S52 G54 G77 G82 W83 T100 K101 H106 E107 D127 V128 F129 D142 I143 2.1.1.56,2.1.1.57,2.7.7.48,3.4.21.91,3.6.1.15,3.6.4.13 0003968,0004482,0004483,0005524,0008168,0032259 Q9Q6P4 20685660 301 GRTLGEVWKERLNQMTKEEFTRYRKEAIIEVDRSAAKHARKEGNVTGGHPVSRGTAKLRWLVERRFLEPVGKVIDLGCGRGGWCYYMATQKRVQEVRGYTKGGPGHEEPQLVQSYGWNIVTMKSGVDVFYRPSECCDTLLCDIGESSSSAEVEEHRTIRVLEMVEDWLHRGPREFCVKVLCPYMPKVIEKMELLQRRYGGGLVRNPLSRNSTHEMYWVSRASGNVVHSVNMTSQVLLGRMEKRTWKGPQYEEDVNLGSGTRA 3lv2 A 2.18 BS02 SFG A 1 Y25 W64 L385 R400 P401 F402 Y19 W50 L369 R384 P385 F386 Y157 E220 D254 A257 K283 Y407 Y143 E206 D240 A243 K269 Y391 2.6.1.62 0004015,0005737,0008483,0009102,0030170 P9WQ81 20565114 600 GLTPEQIIAVDGAHLWHPYSPVVAVAAHGAWLTLIRDGQPIEVLDAMSSWWTAIHGHGHPALDQALTTQLRVMNHVMFGGLTHEPAARLAKLLVDITPAGLDTVFFSDSGSVSVEVAAKMALQYWRGRGLPGKRRLMTWRGGYHGDTFLAMSICDPHGGMHSLWTDVLAAQVFAPQVPRDYDPAYSAAFEAQLAQHAGELAAVVVEPVVQGAGGMRFHDPRYLHDLRDICRRYEVLLIFDEIATGFGRTGALFAADHAGVSPDIMCVGKALTGGYLSLAATLCTADVAHTISAGAALMRGPTFMANPLACAVSVASVELLLGQDWRTRITELAAGLTAGLDTARALPAVTDVRVCGAIGVIECDRPVDLAVATPAALDRGVWLRPFRNLVYAMPPYICTPAEITQITSAMVEVARLVGSLP 3n71 A 2.3 BS01 SFG A 1 K17 R19 Q133 H135 G202 L203 N205 H206 Y252 Y270 F272 K17 R19 Q133 H135 G202 L203 N205 H206 Y252 Y270 F272 2.1.1.354 0003677,0003714,0005515,0005634,0005654,0005737,0006338,0007507,0008168,0010831,0032259,0035914,0042800,0045663,0045892,0046872,0140999 P97443 20943667 491 MTIGSMENVEVFTSEGKGRGLKATKEFWAADVIFAERAYSAVVFDSLINFVCHTCFKRQEKLHRCGQCKFAHYCDRTCQKDAWLNHKNECAAIKKYGKVPNENIRLAARIMWRVEREGTGLTEGCLVSVDDLQNHVEHFGEEEQKELRVDVDTFLQYWPPQSQQFSMQYISHIFGVINCNGFTLSDQRGLQAVGVGIFPNLGLVNHDCWPNCTVIFNNGNHEAVKSMFHTQMRIELRALGKISEGEELTVSYIDFLHLSEERRRQLKKQYYFDCSCEHCQKGLKDDLFLAAKEDPKPSQEVVKEMIQFSKDTLEKIDKARSEGLYHEVVKLCRECLEKQEPVFADTNLYVLRLLSIASEVLSYLQAYEEASHYARRMVDGYMKLYHHNNAQLGMAVMRAGLTNWHAGHIEVGHGMICKAYAILLVTHGPSHPITKDLEAMRMQTEMELRMFRQNEFMYHKMREAALNN 3pdn A 1.7 BS01 SFG A 1 R14 N16 Y124 E130 N132 N181 S202 N205 H206 Y239 Y257 F259 R13 N15 Y123 E129 N131 N180 S201 N204 H205 Y238 Y256 F258 2.1.1.354 0000978,0000993,0001162,0005515,0005634,0005654,0005737,0005829,0006325,0006334,0008168,0014904,0032259,0042054,0045184,0045944,0046872,0071549,0140939,0140954,0140999 Q9H7B4 21167177 429 EPLKVEKFATANRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSESEKLYSFYDLESNINKLTEDRKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIRAS 3qww A 1.8 BS01 SFG A 1 K17 R19 E135 H137 C181 N182 A203 N206 H207 Y240 Y258 F260 K15 R17 E133 H135 C179 N180 A201 N204 H205 Y238 Y256 F258 2.1.1.-,2.1.1.354 0000122,0000993,0002039,0005515,0005634,0005737,0005829,0006325,0006338,0007507,0008168,0008285,0016279,0018026,0018027,0032259,0042054,0043516,0046872,0046975,0140999 Q8R5A0 21738746 434 AEARGGLERFCSAGKGRGLRALRPFHVGDLLFSCPAYACVLTVGERGHHCECCFARKEGLSKCGRCKQAFYCDVECQKEDWPLHKLECSSMVVLGENWNPSETVRLTARILAKQKIHPERTPSEKLLAVREFESHLDKLDNEKKDLIQSDIAALHQFYSKYLEFPDHSSLVVLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIHPGDEVFTSYIDLLYPTEDRNDRLRDSYFFTCECRECTTKDKDKAKVEVRKLSSPPQAEAIRDMVRYARNVIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLYMQDWEGALKYGQKIIKPYSKHYPVYSLNVASMWLKLGRLYMGLENKAAGEKALKKAIAIMEVAHGKDHPYISEIKQEIES 3ru0 A 1.849 BS01 SFG A 1 R14 N16 Y124 N132 C180 N181 S202 N205 H206 Y239 Y257 F259 R11 N13 Y121 N129 C177 N178 S199 N202 H203 Y236 Y254 F256 2.1.1.354 0000978,0000993,0001162,0005515,0005634,0005654,0005737,0005829,0006325,0006334,0008168,0014904,0032259,0042054,0045184,0045944,0046872,0071549,0140939,0140954,0140999 Q9H7B4 21779408 437 LKVEKFATANRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIRAS 3ru0 B 1.849 BS01 SFG B 1 R14 N16 Y124 N132 N181 S202 N205 H206 Y239 Y257 F259 R11 N13 Y121 N129 N178 S199 N202 H203 Y236 Y254 F256 2.1.1.354 0000978,0000993,0001162,0005515,0005634,0005654,0005737,0005829,0006325,0006334,0008168,0014904,0032259,0042054,0045184,0045944,0046872,0071549,0140939,0140954,0140999 Q9H7B4 21779408 437 LKVEKFATANRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECD 3sw9 A 3.05 BS06 SFG A 1 M1105 W1107 S1141 Y1142 R1166 F1167 N1169 H1170 Y1211 F1223 C1225 R1226 M131 W133 S167 Y168 R192 F193 N195 H196 Y237 F249 C251 R252 Y1124 Y1211 Y150 Y237 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054,0046974 IC50=28400nM Q9H9B1 22086334 101 VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS 3sw9 B 3.05 BS06 SFG B 1 M1105 W1107 S1141 R1166 F1167 N1169 H1170 Y1211 F1215 R1226 M131 W133 S167 R192 F193 N195 H196 Y237 F241 R252 Y1124 Y1211 Y150 Y237 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054,0046974 IC50=28400nM Q9H9B1 22086334 102 VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKCRHS 3swr A 2.49 BS01 SFG A 1 F1145 S1146 G1150 L1151 E1168 M1169 L1247 N1578 A1579 V1580 F510 S511 G515 L516 E533 M534 L612 N943 A944 V945 C1226 E1266 R1310 R1312 C591 E631 R675 R677 2.1.1.37 0003677,0003682,0003886,0005634,0006346,0008168,0008270 P26358 300 RQTIRHSTREPTKATTTKLVYQIFDTFFAEQINAFKRRRCGVCEVCQQPECGKCKACKDMVKFGGSGRSKQACQERRCPNMAMKEADDDEEVDDNIPEMPSPKKMHQGKKKKQNKNRISWVGEAVKTDGKKSYYKKVCIDAETLEVGDCVSVIPDDSSKPLYLARVTALWEDSSNGQMFHAHWFCAGTDTVLGATSDPLELFLVDECEDMQLSYIHSKVKVIYKAPSENWAMEGGMDPESLLEGDDGKTYFYQLWYDQDYARFESPPKTQPTEDNKFKFCVSCARLAEMRQKEIPRVLEQLEDLDSRVLYYSATKNGILYRVGDGVYLPPEAFTFNIKLSSPVKRPRKEPVDEDLYPEHYRKYSDYIKGSNLDAPEPYRIGRIKEIFCPKKSNGRPNETDIKIRVNKFYRPENTHKSTPASYHADINLLYWSDEEAVVDFKAVQGRCTVEYGEDLPECVQVYSMGGPNRFYFLEAYNAKSKSFEDPPNHARSPEPEIEIKLPKLRTLDVFSGCGGLSEGFHQAGISDTLWAIEMWDPAAQAFRLNNPGSTVFTEDCNILLKLVMAGETTNSRGQRLPQKGDVEMLCGGPPCQGFSGMNRFNSRTYSKFKNSLVVSFLSYCDYYRPRFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRRAIILAAAPGEKLPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRTITVRDTMSDLPEVRNGASALEISYNGEPQSWFQRQLRGAQYQPILRDHICKDMSALVAARMRHIPLAPGSDWRDLPNIEVRLSDGTMARKLRYTHHDRKNGRSSSGALRGVCSCVEAGKACDPAARQFNTLIPWCLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVLHPEQHRVVSVRECARSQGFPDTYRLFGNILDKHRQVGNAVPPPLAKAIGLEIKLCMLAKA 3tm5 A 2.27 BS01 SFG A 1 H198 A200 H201 L202 M225 S228 T230 E248 K249 H253 D276 A277 N293 H198 A200 H201 L202 M225 S228 T230 E248 K249 H253 D276 A277 N293 2.1.1.256 0003723,0005737,0008033,0008168,0016423,0016740,0030488,0032259,0160117 Q8U248 22362751 401 MKFLLTTAQGIEDIAKREVSLLLKKLGISFQIEEKPLGIEGRLLLEAEKAYYVDEKGRKRELSISTYLNENSRLLHRVIIEIASEKFNGIEKDESEEALKRIKDFVSSLPVEQFVKVSETFAVRSFRKGDHNITSIDIARTVGEAIFERLSRFGTPLVNLDHPAVIFRAELIKDVFFLGIDTTGDSSLHKRPWRVYDHPAHLKASIANAMIELAELDGGSVLDPMCGSGTILIELALRRYSGEIIGIEKYRKHLIGAEMNALAAGVLDKIKFIQGDATQLSQYVDSVDFAISNLPYGLKIGKSMIPDLYMKFFNELAKVLEKRGVFITTEKKAIEEAIAENGFEIIHHRVIGHGGLMVHLYVVKLEHH 3tm5 B 2.27 BS01 SFG B 1 H198 A200 H201 L202 M225 C226 G227 S228 T230 E248 K249 D276 A277 N293 H198 A200 H201 L202 M225 C226 G227 S228 T230 E248 K249 D276 A277 N293 2.1.1.256 0003723,0005737,0008033,0008168,0016423,0016740,0030488,0032259,0160117 Q8U248 22362751 401 MKFLLTTAQGIEDIAKREVSLLLKKLGISFQIEEKPLGIEGRLLLEAEKAYYVDEKGRKRELSISTYLNENSRLLHRVIIEIASEKFNGIEKDESEEALKRIKDFVSSLPVEQFVKVSETFAVRSFRKGDHNITSIDIARTVGEAIFERLSRFGTPLVNLDHPAVIFRAELIKDVFFLGIDTTGDSSLHKRPWRVYDHPAHLKASIANAMIELAELDGGSVLDPMCGSGTILIELALRRYSGEIIGIEKYRKHLIGAEMNALAAGVLDKIKFIQGDATQLSQYVDSVDFAISNLPYGLKIGKKSMIPDLYMKFFNELAKVLEKRGVFITTEKKAIEEAIAENGFEIIHHRVIGHGGLMVHLYVVKLEH 3uj8 A 1.351 BS01 SFG A 1 Y19 I36 S37 G63 D85 I86 I111 R127 D128 A129 H132 Y11 I28 S29 G55 D77 I78 I103 R119 D120 A121 H124 2.1.1.103 0000139,0000234,0005737,0005794,0006656,0008168,0008654,0009058,0016020,0032259 Q8IDQ9 22117061 300 SDKTFLENNQYTDEGVKVYEFIFGENYISSGGLEATKKILSDIELNENSKVLDIGSGLGGGCMYINEKYGAHTHGIDICSNIVNMANERVSGNNKIIFEANDILTKEFPENNFDLIYSRDAILHLSLENKNKLFQKCYKWLKPTGTLLITDYCATEKENWDDEFKEYVKQRKYTLITVEEYADILTACNFKNVVSKDLSDYWNQLLEVEHKYLHENKEEFLKLFSEKKFISLDDGWSRKIKDSKRKMQRWGYFKATKN 4c03 A 1.58 BS01 SFG A 1 Y50 Y51 Y54 M63 R69 G93 A94 G95 L99 E115 A116 P142 V143 E144 E158 M169 S172 Y10 Y11 Y14 M23 R29 G53 A54 G55 L59 E75 A76 P102 V103 E104 E118 M129 S132 D66 E158 E167 H320 D26 E118 E127 H280 2.1.1.319 0000122,0003682,0005515,0005634,0005654,0005730,0006281,0006325,0006338,0008168,0008469,0010821,0016274,0018216,0032259,0035241,0035242,0036211,0042054,0042393,0044020,0045892,0070611,0070612,0090398,1901796,2000059 Q6NZB1 26094878 1378 RTKSERDQLYYECYSDVSVHEEMIADQVRTEAYRLGILKNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQAREVVRLNGLEDRVHVLPGPVETVELPERVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFVAPISDQMLEWRLGFWSQVKQHYGVDMSCMESFATRCLMGHSEIVVQDLSGEDVLARPQRFAQLELARAGLEQELEAGVGGRFRCSCYGSAPLHGFAVWFQVTFPGGDSEKPLVLSTSPLHPATHWKQALLYLNEPVPVEQDTDISGEITLLPSPDNPRRLRILLRYKVGDHEEKTKDFAME 4c03 B 1.58 BS01 SFG B 1 Y50 Y51 Y54 M63 R69 G93 A94 L99 E115 A116 P142 V143 E158 M169 S172 Y4 Y5 Y8 M17 R23 G47 A48 L53 E69 A70 P96 V97 E112 M123 S126 D66 E158 E167 H320 D20 E112 E121 H271 2.1.1.319 0000122,0003682,0005515,0005634,0005654,0005730,0006281,0006325,0006338,0008168,0008469,0010821,0016274,0018216,0032259,0035241,0035242,0036211,0042054,0042393,0044020,0045892,0070611,0070612,0090398,1901796,2000059 Q6NZB1 26094878 1378 DQLYYECYSDVSVHEEMIADQVRTEAYRLGILKNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQAREVVRLNGLEDRVHVLPGPVETVELPERVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFVAPISDQMLEWRLGFWSQVKQHYGVDMSCMESFATRCLMGHSEIVVQDLSGEDVLARPQRFAQLELARAGLEQELEAGVGGRFRCSCYGSAPLHGFAVWFQVTFPGGKPLVLSTSPLHPATHWKQALLYLNEPVPVEQDTDISGEITLLPSPDNPRRLRILLRYKVGDHEEKTKDFAME 4c04 A 1.576 BS01 SFG A 1 M63 R69 G93 A94 G95 L99 E115 A116 E158 M169 S172 M16 R22 G46 A47 G48 L52 E68 A69 E111 M122 S125 D66 E158 E167 H320 D19 E111 E120 H270 2.1.1.319 0000122,0003682,0005515,0005634,0005654,0005730,0006281,0006325,0006338,0008168,0008469,0010821,0016274,0018216,0032259,0035241,0035242,0036211,0042054,0042393,0044020,0045892,0070611,0070612,0090398,1901796,2000059 Q6NZB1 26094878 1377 QLYYECYSDVSVHEEMIADQVRTEAYRLGILKNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQAREVVRLNGLEDRVHVLPGPVETVELPERVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFVAPISDQMLEWRLGFWSQVKQHYGVDMSCMESFATRCLMGHSEIVVQDLSGEDVLARPQRFAQLELARAGLEQELEAGVGGRFRCSCYGSAPLHGFAVWFQVTFPGGKPLVLSTSPLHPATHWKQALLYLNEPVPVEQDTDISGEITLLPSPDNPRRLRILLRYKVGDHEEKTKDFAME 4f86 A 3.0 BS01 SFG A 1 Q30 W37 H57 H58 G113 C114 G115 L136 Q140 N163 M164 N180 E181 S182 Y185 Q5 W12 H32 H33 G88 C89 G90 L111 Q115 N138 M139 N155 E156 S157 Y160 2.1.1.255 0000287,0008168,0008169,0008757,0032259,0042214,1904047 D3KYU3 23090405 501 ATPYQEDIARYWNNEARPVNLRLGDVDGLYHHHYGIGAVDHAALGDPGDGGYEARLIAELHRLESAQAEFLLDHLGPVGPGDTLVDAGCGRGGSMVMAHQRFGCKVEGVTLSAAQAEFGNRRARELGIDDHVRSRVCNMLDTPFEKGTVAASWNNESSMYVDLHDVFAEHSRFLRVGGRYVTVTGCWNPRYGQPSKWVSQINAHFECNIHSRREYLRAMADNRLVPQTVVDLTPETLPYWELRATSSLVTGIEEAFIESYRDGSFQYVLIAADRV 4f86 B 3.0 BS01 SFG B 1 W37 H57 H58 G113 C114 G115 L136 Q140 N163 M164 N180 E181 S182 Y185 W11 H30 H31 G86 C87 G88 L109 Q113 N136 M137 N153 E154 S155 Y158 2.1.1.255 0000287,0008168,0008169,0008757,0032259,0042214,1904047 D3KYU3 23090405 501 TPYQEDIARYWNNARPVNLRLGDVDGLYHHHYGIGAVDHAALGDPGDGGYEARLIAELHRLESAQAEFLLDHLGPVGPGDTLVDAGCGRGGSMVMAHQRFGCKVEGVTLSAAQAEFGNRRARELGIDDHVRSRVCNMLDTPFEKGTVAASWNNESSMYVDLHDVFAEHSRFLRVGGRYVTVTGCWNPRYGQPSKWVSQINAHFECNIHSRREYLRAMADNRLVPQTVVDLTPETLPYWELRATSSLVTGIEEAFIESYRDGSFQYVLIAADRV 4f86 C 3.0 BS01 SFG C 1 W37 H57 H58 G113 C114 G115 T135 L136 Q140 N163 M164 N180 E181 S182 Y185 W11 H31 H32 G87 C88 G89 T109 L110 Q114 N137 M138 N154 E155 S156 Y159 2.1.1.255 0000287,0008168,0008169,0008757,0032259,0042214,1904047 D3KYU3 23090405 501 TPYQEDIARYWNNEARPVNLRLGDVDGLYHHHYGIGAVDHAALGDPGDGGYEARLIAELHRLESAQAEFLLDHLGPVGPGDTLVDAGCGRGGSMVMAHQRFGCKVEGVTLSAAQAEFGNRRARELGIDDHVRSRVCNMLDTPFEKGTVAASWNNESSMYVDLHDVFAEHSRFLRVGGRYVTVTGCWNPRYGQPSKWVSQINAHFECNIHSRREYLRAMADNRLVPQTVVDLTPETLPYWELRATSSLVTGIEEAFIESYRDGSFQYVLIAADRV 4f86 D 3.0 BS01 SFG D 1 W37 H57 H58 G113 G115 L136 Q140 N163 M164 N180 E181 S182 Y185 W13 H33 H34 G86 G88 L109 Q113 N136 M137 N153 E154 S155 Y158 2.1.1.255 0000287,0008168,0008169,0008757,0032259,0042214,1904047 D3KYU3 23090405 501 PATPYQEDIARYWNNEARPVNLRLGDVDGLYHHHYGIGAVDHAALGDPGYEARLIAELHRLESAQAEFLLDHLGPVGPGDTLVDAGCGRGGSMVMAHQRFGCKVEGVTLSAAQAEFGNRRARELGIDDHVRSRVCNMLDTPFEKGTVAASWNNESSMYVDLHDVFAEHSRFLRVGGRYVTVTGCWNPRYGQPSKWVSQINAHFECNIHSRREYLRAMADNRLVPQTVVDLTPETLPYWELRATSSLVTGIEEAFIESYRDGSFQYVLIAADRV 4f86 E 3.0 BS01 SFG E 1 W37 H57 H58 G113 C114 G115 L136 Q140 N163 M164 N180 E181 S182 Y185 W11 H29 H30 G85 C86 G87 L108 Q112 N135 M136 N152 E153 S154 Y157 2.1.1.255 0000287,0008168,0008169,0008757,0032259,0042214,1904047 D3KYU3 23090405 501 TPYQEDIARYWNNRPVNLRLGDVDGLYHHHYGIGAVDHAALGDPGDGGYEARLIAELHRLESAQAEFLLDHLGPVGPGDTLVDAGCGRGGSMVMAHQRFGCKVEGVTLSAAQAEFGNRRARELGIDDHVRSRVCNMLDTPFEKGTVAASWNNESSMYVDLHDVFAEHSRFLRVGGRYVTVTGCWNPRYGQPSKWVSQINAHFECNIHSRREYLRAMADNRLVPQTVVDLTPETLPYWELRATSSLVTGIEEAFIESYRDGSFQYVLIAADRV 4f86 F 3.0 BS01 SFG F 1 W37 H57 H58 G113 C114 T135 L136 Q140 C162 N163 M164 N180 E181 S182 Y185 W11 H29 H30 G82 C83 T104 L105 Q109 C131 N132 M133 N149 E150 S151 Y154 2.1.1.255 0000287,0008168,0008169,0008757,0032259,0042214,1904047 D3KYU3 23090405 501 TPYQEDIARYWNNRPVNLRLGDVDGLYHHHYGIGAVDHAALGDGGYEARLIAELHRLESAQAEFLLDHLGPVGPGDTLVDAGCGRGGSMVMAHQRFGCKVEGVTLSAAQAEFGNRRARELGIDDHVRSRVCNMLDTPFEKGTVAASWNNESSMYVDLHDVFAEHSRFLRVGGRYVTVTGCWNPRYGQPSKWVSQINAHFECNIHSRREYLRAMADNRLVPQTVVDLTPETLPYWELRATSSLVTGIEEAFIESYRDGSFQYVLIAADRV 4f86 G 3.0 BS01 SFG G 1 I33 H57 G113 C114 G115 T135 L136 Q140 N163 M164 N180 E181 S182 Y185 I6 H30 G82 C83 G84 T104 L105 Q109 N132 M133 N149 E150 S151 Y154 2.1.1.255 0000287,0008168,0008169,0008757,0032259,0042214,1904047 D3KYU3 23090405 501 PYQEDIARYWNNEARPVNLRLGDVDGLYHHHYGIGAVDHAALGDPYEARLIAELHRLESAQAEFLLDHLGPVGPGDTLVDAGCGRGGSMVMAHQRFGCKVEGVTLSAAQAEFGNRRARELGIDDHVRSRVCNMLDTPFEKGTVAASWNNESSMYVDLHDVFAEHSRFLRVGGRYVTVTGCWNPRYGQPSKWVSQINAHFECNIHSRREYLRAMADNRLVPQTVVDLTPETLPYWELRATSSLVTGIEEAFIESYRDGSFQYVLIAADRV 4f86 H 3.0 BS01 SFG H 1 W37 H57 H58 G113 C114 G115 T135 L136 Q140 N163 M164 N180 E181 S182 Y185 W11 H29 H30 G81 C82 G83 T103 L104 Q108 N131 M132 N148 E149 S150 Y153 2.1.1.255 0000287,0008168,0008169,0008757,0032259,0042214,1904047 D3KYU3 23090405 501 TPYQEDIARYWNNEARPLRLGDVDGLYHHHYGIGAVDHAALGGGYEARLIAELHRLESAQAEFLLDHLGPVGPGDTLVDAGCGRGGSMVMAHQRFGCKVEGVTLSAAQAEFGNRRARELGIDDHVRSRVCNMLDTPFEKGTVAASWNNESSMYVDLHDVFAEHSRFLRVGGRYVTVTGCWNPRYGQPSKWVSQINAHFECNIHSRREYLRAMADNRLVPQTVVDLTPETLPYWELRATSSLVTGIEEAFIESYRDGSFQYVLIAADRV 4f86 I 3.0 BS01 SFG I 1 Q30 W37 H57 G113 C114 G115 T135 L136 Q140 N163 M164 N180 E181 S182 Y185 Q3 W10 H30 G86 C87 G88 T108 L109 Q113 N136 M137 N153 E154 S155 Y158 2.1.1.255 0000287,0008168,0008169,0008757,0032259,0042214,1904047 D3KYU3 23090405 501 PYQEDIARYWNNEARPVNLRLGDVDGLYHHHYGIGAVDHAALGDPGDGGYEARLIAELHRLESAQAEFLLDHLGPVGPGDTLVDAGCGRGGSMVMAHQRFGCKVEGVTLSAAQAEFGNRRARELGIDDHVRSRVCNMLDTPFEKGTVAASWNNESSMYVDLHDVFAEHSRFLRVGGRYVTVTGCWNPRYGQPSKWVSQINAHFECNIHSRREYLRAMADNRLVPQTVVDLTPETLPYWELRATSSLVTGIEEAFIESYRDGSFQYVLIAADRV 4f86 J 3.0 BS01 SFG J 1 W37 H57 G113 C114 G115 T135 L136 Q140 N163 M164 N180 E181 S182 Y185 W11 H31 G85 C86 G87 T107 L108 Q112 N135 M136 N152 E153 S154 Y157 2.1.1.255 0000287,0008168,0008169,0008757,0032259,0042214,1904047 D3KYU3 23090405 501 TPYQEDIARYWNNEARPVNLRLGDVDGLYHHHYGIGAVDHAALGDPGDYEARLIAELHRLESAQAEFLLDHLGPVGPGDTLVDAGCGRGGSMVMAHQRFGCKVEGVTLSAAQAEFGNRRARELGIDDHVRSRVCNMLDTPFEKGTVAASWNNESSMYVDLHDVFAEHSRFLRVGGRYVTVTGCWNPRYGQPSKWVSQINAHFECNIHSRREYLRAMADNRLVPQTVVDLTPETLPYWELRATSSLVTGIEEAFIESYRDGSFQYVLIAADRV 4f86 K 3.0 BS01 SFG K 1 H57 H58 G113 G115 L136 Q140 N163 M164 N180 E181 S182 Y185 H15 H16 G71 G73 L94 Q98 N121 M122 N138 E139 S140 Y143 2.1.1.255 0000287,0008168,0008169,0008757,0032259,0042214,1904047 D3KYU3 23090405 501 PVNLRLGDVDGLYHHHYGIGAVDHAALGDPGDGGYEARLIAELHRLESAQAEFLLDHLGPVGPGDTLVDAGCGRGGSMVMAHQRFGCKVEGVTLSAAQAEFGNRRARELGIDDHVRSRVCNMLDTPFEKGTVAASWNNESSMYVDLHDVFAEHSRFLRVGGRYVTVTGCWNPRYGQPSKWVSQINAHFECNIHSRREYLRAMADNRLVPQTVVDLTPETLPYWELRATSSLVTGIEEAFIESYRDGSFQYVLIAADRV 4f86 L 3.0 BS01 SFG L 1 W37 H57 H58 G113 G115 L136 Q140 N163 M164 N180 E181 S182 Y185 W12 H32 H33 G86 G88 L109 Q113 N136 M137 N153 E154 S155 Y158 2.1.1.255 0000287,0008168,0008169,0008757,0032259,0042214,1904047 D3KYU3 23090405 501 ATPYQEDIARYWNNEARPVNLRLGDVDGLYHHHYGIGAVDHAALGDPGDYEARLIAELHRLESAQAEFLLDHLGPVGPGDTLVDAGCGRGGSMVMAHQRFGCKVEGVTLSAAQAEFGNRRARELGIDDHVRSRVCNMLDTPFEKGTVAASWNNESSMYVDLHDVFAEHSRFLRVGGRYVTVTGCWNPRYGQPSKWVSQINAHFECNIHSRREYLRAMADNRLVPQTVVDLTPETLPYWELRATSSLVTGIEEAFIESYRDGSFQYVLIAADRV 4onj A 2.807 BS01 SFG A 1 N460 S461 F462 F488 S489 G490 G493 E512 K513 N517 S565 L588 N203 S204 F205 F231 S232 G233 G236 E255 K256 N260 S308 L313 2.1.1.- 0008168 Q76KU6 24855943 700 RLPKPMIGFGVPTEPLPAMVRRTLPEQAVGPPFFYYENVALAPKGVWDTISRFLYDIEPEFVDSKYFCAAARKRGYIHNLPVENRFPLFPLAPRTIHEALPLSKKWWPSWDPRTKLNCLQTAIGSAQLTNRIRKAVEDFDGEPPMRVQKFVLDQCRKWNLVWVGRNKVAPLEPDEVEMLLGFPKNHTRGGGISRTDRYKSLGNSFQVDTVAYHLSVLKDLFPGGINVLSLFSGIGGGEVALYRLGIPLNTVVSVEKSEVNRDIVRSWWEQTNQRGNLIHFNDVQQLNGDRLEQLIESFGGFDLVIGGSPESSLFYDYVRILDLVKSIMSRH 4onj B 2.807 BS01 SFG B 1 N460 S461 F462 F488 E512 K513 N517 S565 P566 L588 N204 S205 F206 F232 E256 K257 N261 S309 P310 L316 2.1.1.- 0008168 Q76KU6 24855943 700 IRLPKPMIGFGVPTEPLPAMVRRTLPEQAVGPPFFYYENVALAPKGVWDTISRFLYDIEPEFVDSKYFCAAARKRGYIHNLPVENRFPLFPLAPRTIHEALPLSKKWWPSWDPRTKLNCLQTAIGSAQLTNRIRKAVEDFDGEPPMRVQKFVLDQCRKWNLVWVGRNKVAPLEPDEVEMLLGFPKNHTRGGGISRTDRYKSLGNSFQVDTVAYHLSVLKDLFPGGINVLSLFSGIGGGEVALYRLGIPLNTVVSVEKSEVNRDIVRSWWEQTNQRGNLIHFNDVQQLNGDRLEQLIESFGGFDLVIGGSPCNESSLFYDYVRILDLVKSIMSR 4onq A 2.502 BS01 SFG A 1 N460 S461 F462 F488 S489 G490 I491 G493 E512 K513 S565 N203 S204 F205 F231 S232 G233 I234 G236 E255 K256 S308 2.1.1.- 0008168 Q76KU6 24855943 700 RLPKPMIGFGVPTEPLPAMVRRTLPSQAVGPPFFYYENVALAPKGVWDTISSSLYDIEPEFVDSKYFCAAARKRGYIHNLPVENRFPLFPLAPRTIHEALPLSKKWWPSWDPRTKLNCLQTAIGSAQLTNRIRKAVEDFDGEPPMRVQKFVLDQCRKWNLVWVGRNKVAPLEPDEVEMLLGFPKNHTRGGGISRTDRYKSLGNSFQVDTVAYHLSVLKDLFPGGINVLSLFSGIGGGEVALYRLGIPLNTVVSVEKSEVNRDIVRSWWEQTNQRGNLIHFNDVQQLNGDRLEQLIESFGGFDLVIGGSPSLFSSYVRILDLVKSIMS 4onq B 2.502 BS01 SFG B 1 N460 S461 F462 F488 S489 G490 G493 E512 K513 N538 D539 S565 N196 S197 F198 F224 S225 G226 G229 E248 K249 N274 D275 S301 2.1.1.- 0008168 Q76KU6 24855943 700 RLPKPMIGFGVPTERTLPSQAVGPPFFYYENVALAPKGVWDTISSSLYDIEPEFVDSKYFCAAARKRGYIHNLPVENRFPLFPLAPRTIHEALPLSKKWWPSWDPRTKLNCLQTAIGSAQLTNRIRKAVEDFDGEPPMRVQKFVLDQCRKWNLVWVGRNKVAPLEPDEVEMLLGFPKNHTRGGGISRTDRYKSLGNSFQVDTVAYHLSVLKDLFPGGINVLSLFSGIGGGEVALYRLGIPLNTVVSVEKSEVNRDIVRSWWEQTNQRGNLIHFNDVQQLNGDRLEQLIESFGGFDLVIGGSLFSSYVRILDLVKSIM 4ox9 Y 3.8035 BS02 SFG Y 1 G32 T33 G34 D55 P56 L104 T109 L110 L196 W197 G32 T33 G34 D55 P56 L104 T109 L110 L196 W197 2.1.1.180 0008168,0032259,0046677 A8C927 24717845 301 MLILKGTKTVDLSKDELTEIIGQFDRVHIDLGTGDGRNIYKLAINDQNTFYIGIDPVKENLFDISKKIIKKPSKGGLSNVVFVIAAAESLPFELKNIADSISILFPWGTLLEYVIKPNRDILSNVADLAKKEAHFEFVTTYSDSYEEAEIKKRGLPLLSKAYFLSEQYKAELSNSGFRIDDVKELDNEYVKQFNSLWAKRLAFGRKRSFFRVSGHVSKH 4p7k A 1.22 BS01 SFG A 1 K89 G109 Y111 S115 E133 M134 Y138 A161 S162 D184 H185 W186 K45 G65 Y67 S71 E89 M90 Y94 A117 S118 D140 H141 W142 D184 K187 D212 N213 E242 D140 K143 D168 N169 E198 2.1.1.6 0000287,0006584,0008171,0016206 P22734 25084335 300 GDTKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEMNPDYAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEKCGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPSSPDK 4pyl A 2.2 BS02 SFG A 1 M83 N84 V85 G109 Y111 Y114 S115 E133 M134 Y138 A161 S162 D184 H185 W186 M37 N38 V39 G63 Y65 Y68 S69 E87 M88 Y92 A115 S116 D138 H139 W140 D184 K187 D212 N213 E242 D138 K141 D166 N167 E196 2.1.1.6 0000287,0006584,0008171,0016206 P22734 25084335 302 TKEQRILRYVQQNAKPGDPQSVLEAIDTYCTQKEWAMNVGDAKGQIMDAVIREYSPSLVLELGAYCGYSAVRMARLLQPGARLLTMEMNPDYAAITQQMLNFAGLQDKVTILNGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEKCGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAIYQGPS 4r8s A 1.48 BS01 SFG A 1 S56 G58 G81 G86 W87 T104 K105 H110 K130 D131 V132 F133 D146 S50 G52 G75 G80 W81 T98 K99 H104 K124 D125 V126 F127 D140 3.4.21.91,3.6.1.15,3.6.4.13 0004482,0004483,0008168,0032259 C1KBQ3 25241250 301 ETLGEKWKKKLNQLSRKEFDLYKKSGITEVDRTEAKEGLKRGETTHHAVSRGSAKLQWFVERNMVIPEGRVIDLGCGRGGWSYYCAGLKKVTEVRGYTKGGPGHEEPVPMSTYGWNIVKLMSGKDVFYLPPEKCDTLLCDIGESSPSPTVEESRTIRVLKMVEPWLKNNQFCIKVLNPYMPTVIEHLERLQRKHGGMLVRNPLSRNSTHEMYWISNGTGNIVSSVNMVSRLLLNRFTMTHRRPTIEKDVDLGAGTR 4r8s B 1.48 BS01 SFG B 1 S56 G81 G86 W87 T104 K105 H110 E111 K130 D131 V132 F133 D146 I147 S50 G75 G80 W81 T98 K99 H104 E105 K124 D125 V126 F127 D140 I141 3.4.21.91,3.6.1.15,3.6.4.13 0004482,0004483,0008168,0032259 C1KBQ3 25241250 301 ETLGEKWKKKLNQLSRKEFDLYKKSGITEVDRTEAKEGLKRGETTHHAVSRGSAKLQWFVERNMVIPEGRVIDLGCGRGGWSYYCAGLKKVTEVRGYTKGGPGHEEPVPMSTYGWNIVKLMSGKDVFYLPPEKCDTLLCDIGESSPSPTVEESRTIRVLKMVEPWLKNNQFCIKVLNPYMPTVIEHLERLQRKHGGMLVRNPLSRNSTHEMYWISNGTGNIVSSVNMVSRLLLNRFTMTHRRPTIEKDVDLGAGTR 4rtj A 1.99 BS02 SFG A 1 A11 P34 F35 V36 A38 D54 I55 S164 Y165 D181 A9 P32 F33 V34 A36 D52 I53 S162 Y163 D179 2.1.1.72 0003676,0003677,0005515,0006260,0006261,0006298,0008168,0009007,0009307,0009411,0032259,0043565,1902328,1904047 P0AEE8 25845600 301 KNRAFLKWAGGKYPLLDDIKRHLPKGECLVEPFVGAGSVFLNTDFSRYILADINSDLISLYNIVKMRTDEYVQAARELFVPETNCAEVYYQFREEFNKSQDPFRRAVLFLYLNRYGYNGLCRYNLRGEFNVPFGRYKKPYFPEAELYHFAEKAQNAFFYCESYADSMARADDSSVVYCDPPYAPLSTNSFTLEQQAHLAEIAEGLVERHIPVLISNHDTMLTREWYQRAKLHVVKVRRRKKVDELLALYKP 4rtl A 2.193 BS02 SFG A 1 F35 V36 A38 D54 I55 D181 F33 V34 A36 D52 I53 D179 2.1.1.72 0003676,0003677,0005515,0006260,0006261,0006298,0008168,0009007,0009307,0009411,0032259,0043565,1902328,1904047 P0AEE8 25845600 301 KNRAFLKWAGGKYPLLDDIKRHLPKGECLVEPFVGAGSVFLNTDFSRYILADINSDLISLYNIVKMRTDEYVQAARELFVPETNCAEVYYQFREEFNKSQDPFRRAVLFLYLNRYGYNGLCRYNLRGEFNVPFGRYKKPYFPEAELYHFAEKAQNAFFYCESYADSMARADDSSVVYCDPPYAPLSANSFTLEQQAHLAEIAEGLVERHIPVLISNHDTMLTREWYQRAKLHVVKVRRSIRKKVDELLALYKPG 4rto A 2.69 BS02 SFG A 1 A11 G12 P34 F35 V36 A38 D54 I55 S164 Y165 D181 A9 G10 P32 F33 V34 A36 D52 I53 S162 Y163 D179 2.1.1.72 0003676,0003677,0005515,0006260,0006261,0006298,0008168,0009007,0009307,0009411,0032259,0043565,1902328,1904047 P0AEE8 25845600 301 KNRAFLKWAGGKYPLLDDIKRHLPKGECLVEPFVGAGSVFLNTDFSRYILADINSDLISLYNIVKMRTDEYVQAARELFVPETNCAEVYYQFREEFNKSQDPFRRAVLFLYLNRYGYNGLCRYNLRGEFNVPFGRYKKPYFPEAELYHFAEKAQNAFFYCESYADSMARADDSSVVYCDPPYAPLSSFTLEQQAHLAEIAEGLVERHIPVLISNHDTMLTREWYQRAKLHVVKVRRSKKVDELLALYKP 4x60 A 2.35 BS01 SFG A 1 Y324 Y334 G365 P370 E392 K393 D419 M420 E435 L436 Y312 Y322 G353 P358 E380 K381 D407 M408 E423 L424 2.1.1.320 0000387,0000785,0002039,0003714,0005515,0005634,0005654,0005694,0005737,0005794,0005829,0006325,0006338,0006353,0006355,0006479,0007088,0008168,0008327,0008469,0010468,0016274,0018216,0032259,0032922,0032991,0034709,0035097,0035243,0035246,0042054,0042118,0042802,0043021,0044020,0044027,0044877,0045596,0045892,0046982,0048026,0048511,0048714,0070372,0070888,0090161,0097421,0140938,1901796,1904992 IC50=8600nM O14744 25915199 701 RVSSGRDLNCVPEIADTLGAVAKQGFDFLCMPVFHPRFKREFIQEPAKNRPGPQTRSDLLLSGRDWNTLIVGKLSPWIRPDSKVEKIRRNSEAAMLQELNFGAYLGLPAFLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAPEDLRDDIIENAPTTHTEEYSGEEKTWMWWHNFRTLCDYSKRIAVALEIGADLPSNHVIDRWLGEPIKAAILPTSIFLTNKKGFPVLSKMHQRLIFRLLKLEVQFIITGTNHHSEKEFCSYLQYLEYLSQNRPPPNAYELFAKGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKDTNVQVLMVLGAGRGPLVNASLRAAKQADRRIKLYAVEKNPNAVVTLENWQFEEWGSQVTVVSSDMREWVAPEKADIIVSELLGSFADNELSPECLDGAQHFLKDDGVSIPGEYTSFLAPISSSKLYNEVRACREKDRDPEAQFEMPYVVRLHNFHQLSAPQPCFTFSHPNRDPMIDNNRYCTLEFPVEVNTVLHGFAGYFETVLYQDITLSIRPETHSPGMFSWFPILFPIKQPITVREGQTICVRFWRCSNSKKVWYEWAVTAPVCSAIHNPTGRSYTIGL 4yvh A 1.6 BS01 SFG A 1 Y86 L87 S88 P89 Q90 G113 Y115 E116 S132 L138 G140 G141 P144 Y88 L89 S90 P91 Q92 G115 Y117 E118 S134 L140 G142 G143 P146 P89 E116 R154 D169 P91 E118 R156 D163 2.1.1.228 0002939,0005737,0005829,0006400,0008033,0008168,0032259,0052906 P43912 26183229 301 SHMWIGVISLFPEMFKAITEFGVTGRAVKHNLLKVECWNPRDFTFDKHKTVDDRPYGGGPGMLMMVQPLRDAIHTAKAAAGEGAKVIYLSPQGRKLDQGGVTELAQNQKLILVCGRYEGIDERLIQTEIDEEWSIGDYVLTGGELPAMTLIDAVARFIPGVLDSFADGLLDCPHYTRPEVLEGLTVPPVLMSGHHEEIRKWRLKQSLQRTWLRRPELLEGLALTDEQRKLLKEAQAEHNS 4yvi A 3.01 BS02 SFG A 1 L87 S88 P89 Q90 G113 Y115 E116 S132 L138 T139 G140 G141 P144 L88 S89 P90 Q91 G114 Y116 E117 S133 L139 T140 G141 G142 P145 P89 E116 R154 D169 P90 E117 R155 D162 2.1.1.228 0002939,0005737,0005829,0006400,0008033,0008168,0032259,0052906 P43912 26183229 301 HMWIGVISLFPEMFKAITEFGVTGRAVKHNLLKVECWNPRDFTFDKHKTVDDRPYGGGPGMLMMVQPLRDAIHTAKAAAGEGAKVIYLSPQGRKLDQGGVTELAQNQKLILVCGRYEGIDERLIQTEIDEEWSIGDYVLTGGELPAMTLIDAVARFIPGVLDSFADGLLDCPHYTRPEVLEGLTVPPVLMSGHHEEIRKWRLKQSLQRTWLRRPELLEGLALTDEQRKLLKEAQAEHNS 4yvi B 3.01 BS02 SFG A 1 D169 S170 D177 D172 S173 D180 P89 E116 R154 D169 P92 E119 R157 D172 2.1.1.228 0002939,0005737,0005829,0006400,0008033,0008168,0032259,0052906 P43912 26183229 301 GSHMWIGVISLFPEMFKAITEFGVTGRAVKHNLLKVECWNPRDFTFDKHKTVDDRPYGGGPGMLMMVQPLRDAIHTAKAAAGEGAKVIYLSPQGRKLDQGGVTELAQNQKLILVCGRYEGIDERLIQTEIDEEWSIGDYVLTGGELPAMTLIDAVARFIPGVLGKQASAEEDSFADGLLDCPHYTRPEVLEGLTVPPVLMSGHHEEIRKWRLKQSLQRTWLRRPELLEGLALTDEQRKLLKEAQAEHNS 4yvi B 3.01 BS03 SFG B 1 Y86 L87 S88 P89 Q90 G113 Y115 E116 S132 L138 T139 G140 G141 P144 Y89 L90 S91 P92 Q93 G116 Y118 E119 S135 L141 T142 G143 G144 P147 P89 E116 R154 D169 P92 E119 R157 D172 2.1.1.228 0002939,0005737,0005829,0006400,0008033,0008168,0032259,0052906 P43912 26183229 301 GSHMWIGVISLFPEMFKAITEFGVTGRAVKHNLLKVECWNPRDFTFDKHKTVDDRPYGGGPGMLMMVQPLRDAIHTAKAAAGEGAKVIYLSPQGRKLDQGGVTELAQNQKLILVCGRYEGIDERLIQTEIDEEWSIGDYVLTGGELPAMTLIDAVARFIPGVLGKQASAEEDSFADGLLDCPHYTRPEVLEGLTVPPVLMSGHHEEIRKWRLKQSLQRTWLRRPELLEGLALTDEQRKLLKEAQAEHNS 4yvj A 2.9 BS02 SFG A 1 L87 S88 P89 Q90 G113 Y115 E116 S132 L138 T139 G140 G141 P144 L89 S90 P91 Q92 G115 Y117 E118 S134 L140 T141 G142 G143 P146 P89 E116 R154 D169 P91 E118 R156 D162 2.1.1.228 0002939,0005737,0005829,0006400,0008033,0008168,0032259,0052906 P43912 26183229 301 SHMWIGVISLFPEMFKAITEFGVTGRAVKHNLLKVECWNPRDFTFDKHKTVDDRPYGGGPGMLMMVQPLRDAIHTAKAAAGEGAKVIYLSPQGRKLDQGGVTELAQNQKLILVCGRYEGIDERLIQTEIDEEWSIGDYVLTGGELPAMTLIDAVARFIPGVDSFADGLLDCPHYTRPEVLEGLTVPPVLMSGHHEEIRKWRLKQSLQRTWLRRPELLEGLALTDEQRKLLKEAQAEHNS 4yvj B 2.9 BS02 SFG A 1 D169 S170 D177 D172 S173 D180 P89 E116 R154 D169 P92 E119 R157 D172 2.1.1.228 0002939,0005737,0005829,0006400,0008033,0008168,0032259,0052906 P43912 26183229 301 GSHMWIGVISLFPEMFKAITEFGVTGRAVKHNLLKVECWNPRDFTFDKHKTVDDRPYGGGPGMLMMVQPLRDAIHTAKAAAGEGAKVIYLSPQGRKLDQGGVTELAQNQKLILVCGRYEGIDERLIQTEIDEEWSIGDYVLTGGELPAMTLIDAVARFIPGVLGKQASAEEDSFADGLLDCPHYTRPEVLEGLTVPPVLMSGHHEEIRKWRLKQSLQRTWLRRPELLEGLALTDEQRKLLKEAQAEHNS 4yvj B 2.9 BS03 SFG B 1 L87 S88 P89 Q90 G113 R114 Y115 E116 S132 L138 G140 G141 P144 L90 S91 P92 Q93 G116 R117 Y118 E119 S135 L141 G143 G144 P147 P89 E116 R154 D169 P92 E119 R157 D172 2.1.1.228 0002939,0005737,0005829,0006400,0008033,0008168,0032259,0052906 P43912 26183229 301 GSHMWIGVISLFPEMFKAITEFGVTGRAVKHNLLKVECWNPRDFTFDKHKTVDDRPYGGGPGMLMMVQPLRDAIHTAKAAAGEGAKVIYLSPQGRKLDQGGVTELAQNQKLILVCGRYEGIDERLIQTEIDEEWSIGDYVLTGGELPAMTLIDAVARFIPGVLGKQASAEEDSFADGLLDCPHYTRPEVLEGLTVPPVLMSGHHEEIRKWRLKQSLQRTWLRRPELLEGLALTDEQRKLLKEAQAEHNS 4yvk A 3.002 BS02 SFG A 1 L87 S88 P89 Q90 G113 R114 Y115 E116 S132 L138 G140 G141 P144 L89 S90 P91 Q92 G115 R116 Y117 E118 S134 L140 G142 G143 P146 P89 E116 R154 D169 P91 E118 R156 D162 2.1.1.228 0002939,0005737,0005829,0006400,0008033,0008168,0032259,0052906 P43912 26183229 301 SHMWIGVISLFPEMFKAITEFGVTGRAVKHNLLKVECWNPRDFTFDKHKTVDDRPYGGGPGMLMMVQPLRDAIHTAKAAAGEGAKVIYLSPQGRKLDQGGVTELAQNQKLILVCGRYEGIDERLIQTEIDEEWSIGDYVLTGGELPAMTLIDAVARFIPGVDSFADGLLDCPHYTRPEVLEGLTVPPVLMSGHHEEIRKWRLKQSLQRTWLRRPELLEGLALTDEQRKLLKEAQAEHNS 4yvk B 3.002 BS02 SFG A 1 D169 S170 D177 D172 S173 D180 P89 E116 R154 D169 P92 E119 R157 D172 2.1.1.228 0002939,0005737,0005829,0006400,0008033,0008168,0032259,0052906 P43912 26183229 301 GSHMWIGVISLFPEMFKAITEFGVTGRAVKHNLLKVECWNPRDFTFDKHKTVDDRPYGGGPGMLMMVQPLRDAIHTAKAAAGEGAKVIYLSPQGRKLDQGGVTELAQNQKLILVCGRYEGIDERLIQTEIDEEWSIGDYVLTGGELPAMTLIDAVARFIPGVLGKQASAEEDSFADGLLDCPHYTRPEVLEGLTVPPVLMSGHHEEIRKWRLKQSLQRTWLRRPELLEGLALTDEQRKLLKEAQAEHNS 4yvk B 3.002 BS03 SFG B 1 Y86 L87 S88 P89 Q90 G113 Y115 E116 S132 I133 L138 G140 G141 P144 Y89 L90 S91 P92 Q93 G116 Y118 E119 S135 I136 L141 G143 G144 P147 P89 E116 R154 D169 P92 E119 R157 D172 2.1.1.228 0002939,0005737,0005829,0006400,0008033,0008168,0032259,0052906 P43912 26183229 301 GSHMWIGVISLFPEMFKAITEFGVTGRAVKHNLLKVECWNPRDFTFDKHKTVDDRPYGGGPGMLMMVQPLRDAIHTAKAAAGEGAKVIYLSPQGRKLDQGGVTELAQNQKLILVCGRYEGIDERLIQTEIDEEWSIGDYVLTGGELPAMTLIDAVARFIPGVLGKQASAEEDSFADGLLDCPHYTRPEVLEGLTVPPVLMSGHHEEIRKWRLKQSLQRTWLRRPELLEGLALTDEQRKLLKEAQAEHNS 5c9z A 2.36 BS01 SFG A 1 Y324 Y334 G365 P370 E392 K393 D419 M420 E435 L436 Y312 Y322 G353 P358 E380 K381 D407 M408 E423 L424 2.1.1.320 0000387,0000785,0002039,0003714,0005515,0005634,0005654,0005694,0005737,0005794,0005829,0006325,0006338,0006353,0006355,0006479,0007088,0008168,0008327,0008469,0010468,0016274,0018216,0032259,0032922,0032991,0034709,0035097,0035243,0035246,0042054,0042118,0042802,0043021,0044020,0044027,0044877,0045596,0045892,0046982,0048026,0048511,0048714,0070372,0070888,0090161,0097421,0140938,1901796,1904992 IC50=8600nM O14744 701 RVSSGRDLNCVPEIADTLGAVAKQGFDFLCMPVFHPRFKREFIQEPAKNRPGPQTRSDLLLSGRDWNTLIVGKLSPWIRPDSKVEKIRRNSEAAMLQELNFGAYLGLPAFLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAPEDLRDDIIENAPTTHTEEYSGEEKTWMWWHNFRTLCDYSKRIAVALEIGADLPSNHVIDRWLGEPIKAAILPTSIFLTNKKGFPVLSKMHQRLIFRLLKLEVQFIITGTNHHSEKEFCSYLQYLEYLSQNRPPPNAYELFAKGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKDTNVQVLMVLGAGRGPLVNASLRAAKQADRRIKLYAVEKNPNAVVTLENWQFEEWGSQVTVVSSDMREWVAPEKADIIVSELLGSFADNELSPECLDGAQHFLKDDGVSIPGEYTSFLAPISSSKLYNEVRACREKDRDPEAQFEMPYVVRLHNFHQLSAPQPCFTFSHPNRDPMIDNNRYCTLEFPVEVNTVLHGFAGYFETVLYQDITLSIRPETHSPGMFSWFPILFPIKQPITVREGQTICVRFWRCSNSKKVWYEWAVTAPVCSAIHNPTGRSYTIGL 5dwq A 2.36 BS01 SFG A 1 Y149 F150 Y153 M162 R168 G192 C193 I197 L198 E214 A215 E257 M268 S271 Y15 F16 Y19 M28 R34 G58 C59 I63 L64 E80 A81 E123 M134 S137 D165 E257 E266 H414 D31 E123 E132 H280 2.1.1.319 0016274,0018216 Q86X55 26551522 501 SVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRY 5dwq B 2.36 BS02 SFG B 1 Y149 F150 Y153 Q159 M162 R168 G192 C193 I197 L198 E214 A215 K241 V242 E243 E257 M268 Y15 F16 Y19 Q25 M28 R34 G58 C59 I63 L64 E80 A81 K107 V108 E109 E123 M134 D165 E257 E266 H414 D31 E123 E132 H280 2.1.1.319 0016274,0018216 Q86X55 26551522 501 SVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYT 5dwq C 2.36 BS01 SFG C 1 Y149 F150 Y153 M162 R168 G192 C193 I197 E214 A215 K241 V242 E243 M268 Y14 F15 Y18 M27 R33 G57 C58 I62 E79 A80 K106 V107 E108 M133 D165 E257 E266 H414 D30 E122 E131 H279 2.1.1.319 0016274,0018216 Q86X55 26551522 501 VFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYT 5dwq D 2.36 BS02 SFG D 1 Y149 Y153 M162 R168 G192 C193 I197 L198 E214 A215 K241 V242 E243 E257 M268 S271 Y15 Y19 M28 R34 G58 C59 I63 L64 E80 A81 K107 V108 E109 E123 M134 S137 D165 E257 E266 H414 D31 E123 E132 H280 2.1.1.319 0016274,0018216 Q86X55 26551522 501 SVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYT 5dx0 A 2.05 BS02 SFG A 1 Y149 F150 Y153 M162 R168 G192 C193 I197 L198 E214 A215 K241 V242 E243 E257 M268 S271 Y15 F16 Y19 M28 R34 G58 C59 I63 L64 E80 A81 K107 V108 E109 E123 M134 S137 D165 E257 E266 H414 D31 E123 E132 H280 2.1.1.319 0016274,0018216 Q86X55 26551522 501 SVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYT 5dx0 B 2.05 BS02 SFG B 1 Y149 F150 Y153 Q159 M162 R168 G192 C193 I197 L198 E214 A215 K241 V242 E243 E257 M268 Y15 F16 Y19 Q25 M28 R34 G58 C59 I63 L64 E80 A81 K107 V108 E109 E123 M134 D165 E257 E266 H414 D31 E123 E132 H280 2.1.1.319 0016274,0018216 Q86X55 26551522 501 SVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYT 5dx0 C 2.05 BS02 SFG C 1 Y149 F150 Y153 Q159 M162 R168 G192 C193 I197 L198 E214 A215 K241 E243 E257 M268 Y15 F16 Y19 Q25 M28 R34 G58 C59 I63 L64 E80 A81 K107 E109 E123 M134 D165 E257 E266 H414 D31 E123 E132 H280 2.1.1.319 0016274,0018216 Q86X55 26551522 501 SVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYT 5dx0 D 2.05 BS02 SFG D 1 Y149 F150 Y153 Q159 M162 R168 G192 C193 I197 L198 E214 A215 K241 V242 E243 E257 M268 Y15 F16 Y19 Q25 M28 R34 G58 C59 I63 L64 E80 A81 K107 V108 E109 E123 M134 D165 E257 E266 H414 D31 E123 E132 H280 2.1.1.319 0016274,0018216 Q86X55 26551522 501 SVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYT 5dx1 A 1.93 BS02 SFG A 1 Y149 F150 Y153 M162 R168 G192 C193 I197 L198 E214 A215 E257 M268 Y16 F17 Y20 M29 R35 G59 C60 I64 L65 E81 A82 E124 M135 D165 E257 E266 H414 D32 E124 E133 H281 2.1.1.319 0016274,0018216 Q86X55 26551522 501 RSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYT 5dx1 B 1.93 BS02 SFG B 1 Y149 F150 Y153 Q159 M162 R168 G192 C193 I197 E214 A215 K241 E243 E257 M268 Y16 F17 Y20 Q26 M29 R35 G59 C60 I64 E81 A82 K108 E110 E124 M135 D165 E257 E266 H414 D32 E124 E133 H281 2.1.1.319 0016274,0018216 Q86X55 26551522 501 RSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYT 5dx1 C 1.93 BS02 SFG C 1 Y149 F150 Y153 M162 R168 G192 C193 I197 L198 E214 A215 K241 E243 E257 M268 Y16 F17 Y20 M29 R35 G59 C60 I64 L65 E81 A82 K108 E110 E124 M135 D165 E257 E266 H414 D32 E124 E133 H281 2.1.1.319 0016274,0018216 Q86X55 26551522 501 RSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYT 5dx1 D 1.93 BS02 SFG D 1 Y149 F150 Y153 Q159 M162 R168 G192 C193 I197 E214 A215 K241 V242 E243 E257 M268 Y16 F17 Y20 Q26 M29 R35 G59 C60 I64 E81 A82 K108 V109 E110 E124 M135 D165 E257 E266 H414 D32 E124 E133 H281 2.1.1.319 0016274,0018216 Q86X55 26551522 501 RSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYT 5dx8 A 1.94 BS02 SFG A 1 Y149 F150 Y153 M162 R168 G192 C193 I197 L198 E214 A215 K241 V242 E243 E257 M268 Y16 F17 Y20 M29 R35 G59 C60 I64 L65 E81 A82 K108 V109 E110 E124 M135 D165 E257 E266 H414 D32 E124 E133 H281 2.1.1.319 0016274,0018216 Q86X55 26551522 501 RSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYT 5dx8 B 1.94 BS02 SFG B 1 Y149 F150 Y153 M162 R168 G192 C193 I197 L198 E214 A215 K241 V242 E243 E257 M268 Y16 F17 Y20 M29 R35 G59 C60 I64 L65 E81 A82 K108 V109 E110 E124 M135 D165 E257 E266 H414 D32 E124 E133 H281 2.1.1.319 0016274,0018216 Q86X55 26551522 501 RSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYT 5dx8 C 1.94 BS02 SFG C 1 Y149 F150 Y153 M162 R168 G192 C193 I197 L198 E214 A215 K241 V242 E243 E257 M268 Y16 F17 Y20 M29 R35 G59 C60 I64 L65 E81 A82 K108 V109 E110 E124 M135 D165 E257 E266 H414 D32 E124 E133 H281 2.1.1.319 0016274,0018216 Q86X55 26551522 501 RSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRY 5dx8 D 1.94 BS02 SFG D 1 Y149 F150 Y153 Q159 M162 R168 G192 C193 I197 L198 E214 A215 K241 E257 M268 Y16 F17 Y20 Q26 M29 R35 G59 C60 I64 L65 E81 A82 K108 E124 M135 D165 E257 E266 H414 D32 E124 E133 H281 2.1.1.319 0016274,0018216 Q86X55 26551522 501 RSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRY 5dxa A 2.07 BS02 SFG A 1 Y149 F150 Y153 Q159 M162 R168 G192 C193 I197 L198 E214 A215 K241 V242 E243 E257 M268 S271 Y16 F17 Y20 Q26 M29 R35 G59 C60 I64 L65 E81 A82 K108 V109 E110 E124 M135 S138 D165 E257 E266 H414 D32 E124 E133 H281 2.1.1.319 0016274,0018216 Q86X55 26551522 501 RSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYT 5dxa B 2.07 BS02 SFG B 1 Y149 F150 Y153 M162 R168 G192 C193 I197 L198 E214 A215 K241 E243 E257 M268 Y15 F16 Y19 M28 R34 G58 C59 I63 L64 E80 A81 K107 E109 E123 M134 D165 E257 E266 H414 D31 E123 E132 H280 2.1.1.319 0016274,0018216 Q86X55 26551522 501 SVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYT 5dxa C 2.07 BS01 SFG C 1 Y149 F150 Y153 M162 R168 G192 C193 I197 L198 E214 A215 K241 E243 E257 M268 S271 Y16 F17 Y20 M29 R35 G59 C60 I64 L65 E81 A82 K108 E110 E124 M135 S138 D165 E257 E266 H414 D32 E124 E133 H281 2.1.1.319 0016274,0018216 Q86X55 26551522 501 RSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRY 5dxa D 2.07 BS02 SFG D 1 Y149 F150 Y153 Q159 M162 R168 G192 C193 I197 L198 E214 A215 K241 V242 E243 E257 M268 Y15 F16 Y19 Q25 M28 R34 G58 C59 I63 L64 E80 A81 K107 V108 E109 E123 M134 D165 E257 E266 H414 D31 E123 E132 H280 2.1.1.319 0016274,0018216 Q86X55 26551522 501 SVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYT 5dxj A 1.95 BS01 SFG A 1 Y149 F150 Y153 M162 R168 G192 C193 G194 I197 L198 E214 A215 K241 V242 E243 E257 M268 S271 Y16 F17 Y20 M29 R35 G59 C60 G61 I64 L65 E81 A82 K108 V109 E110 E124 M135 S138 D165 E257 E266 H414 D32 E124 E133 H281 2.1.1.319 0016274,0018216 Q86X55 26551522 501 RSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYT 5dxj B 1.95 BS01 SFG B 1 Y149 F150 Y153 M162 R168 G192 C193 I197 L198 E214 A215 K241 V242 E243 E257 M268 S271 Y16 F17 Y20 M29 R35 G59 C60 I64 L65 E81 A82 K108 V109 E110 E124 M135 S138 D165 E257 E266 H414 D32 E124 E133 H281 2.1.1.319 0016274,0018216 Q86X55 26551522 501 RSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYT 5dxj C 1.95 BS01 SFG C 1 Y149 F150 Y153 M162 R168 G192 C193 I197 L198 E214 A215 K241 V242 E243 E257 M268 Y16 F17 Y20 M29 R35 G59 C60 I64 L65 E81 A82 K108 V109 E110 E124 M135 D165 E257 E266 H414 D32 E124 E133 H281 2.1.1.319 0016274,0018216 Q86X55 26551522 501 RSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRY 5dxj D 1.95 BS01 SFG D 1 Y149 F150 Y153 Q159 M162 R168 G192 C193 G194 I197 L198 E214 A215 K241 V242 E243 E257 M268 Y16 F17 Y20 Q26 M29 R35 G59 C60 G61 I64 L65 E81 A82 K108 V109 E110 E124 M135 D165 E257 E266 H414 D32 E124 E133 H281 2.1.1.319 0016274,0018216 Q86X55 26551522 501 RSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYT 5emj A 2.273 BS01 SFG A 1 L315 Y324 Y334 G365 P370 E392 K393 D419 M420 E435 L436 L303 Y312 Y322 G353 P358 E380 K381 D407 M408 E423 L424 2.1.1.320 0000387,0000785,0002039,0003714,0005515,0005634,0005654,0005694,0005737,0005794,0005829,0006325,0006338,0006353,0006355,0006479,0007088,0008168,0008327,0008469,0010468,0016274,0018216,0032259,0032922,0032991,0034709,0035097,0035243,0035246,0042054,0042118,0042802,0043021,0044020,0044027,0044877,0045596,0045892,0046982,0048026,0048511,0048714,0070372,0070888,0090161,0097421,0140938,1901796,1904992 IC50=8600nM O14744 26985292 701 RVSSGRDLNCVPEIADTLGAVAKQGFDFLCMPVFHPRFKREFIQEPAKNRPGPQTRSDLLLSGRDWNTLIVGKLSPWIRPDSKVEKIRRNSEAAMLQELNFGAYLGLPAFLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAPEDLRDDIIENAPTTHTEEYSGEEKTWMWWHNFRTLCDYSKRIAVALEIGADLPSNHVIDRWLGEPIKAAILPTSIFLTNKKGFPVLSKMHQRLIFRLLKLEVQFIITGTNHHSEKEFCSYLQYLEYLSQNRPPPNAYELFAKGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKDTNVQVLMVLGAGRGPLVNASLRAAKQADRRIKLYAVEKNPNAVVTLENWQFEEWGSQVTVVSSDMREWVAPEKADIIVSELLGSFADNELSPECLDGAQHFLKDDGVSIPGEYTSFLAPISSSKLYNEVRACREKDRDPEAQFEMPYVVRLHNFHQLSAPQPCFTFSHPNRDPMIDNNRYCTLEFPVEVNTVLHGFAGYFETVLYQDITLSIRPETHSPGMFSWFPILFPIKQPITVREGQTICVRFWRCSNSKKVWYEWAVTAPVCSAIHNPTGRSYTIGL 5emk A 2.52 BS01 SFG A 1 Y324 Y334 G365 A366 P370 L371 E392 K393 D419 M420 E435 L436 Y312 Y322 G353 A354 P358 L359 E380 K381 D407 M408 E423 L424 2.1.1.320 0000387,0000785,0002039,0003714,0005515,0005634,0005654,0005694,0005737,0005794,0005829,0006325,0006338,0006353,0006355,0006479,0007088,0008168,0008327,0008469,0010468,0016274,0018216,0032259,0032922,0032991,0034709,0035097,0035243,0035246,0042054,0042118,0042802,0043021,0044020,0044027,0044877,0045596,0045892,0046982,0048026,0048511,0048714,0070372,0070888,0090161,0097421,0140938,1901796,1904992 IC50=8600nM O14744 26985292 701 RVSSGRDLNCVPEIADTLGAVAKQGFDFLCMPVFHPRFKREFIQEPAKNRPGPQTRSDLLLSGRDWNTLIVGKLSPWIRPDSKVEKIRRNSEAAMLQELNFGAYLGLPAFLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAPEDLRDDIIENAPTTHTEEYSGEEKTWMWWHNFRTLCDYSKRIAVALEIGADLPSNHVIDRWLGEPIKAAILPTSIFLTNKKGFPVLSKMHQRLIFRLLKLEVQFIITGTNHHSEKEFCSYLQYLEYLSQNRPPPNAYELFAKGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKDTNVQVLMVLGAGRGPLVNASLRAAKQADRRIKLYAVEKNPNAVVTLENWQFEEWGSQVTVVSSDMREWVAPEKADIIVSELLGSFADNELSPECLDGAQHFLKDDGVSIPGEYTSFLAPISSSKLYNEVRACREKDRDPEAQFEMPYVVRLHNFHQLSAPQPCFTFSHPNRDPMIDNNRYCTLEFPVEVNTVLHGFAGYFETVLYQDITLSIRPETHSPGMFSWFPILFPIKQPITVREGQTICVRFWRCSNSKKVWYEWAVTAPVCSAIHNPTGRSYTIGL 5emm A 2.37 BS01 SFG A 1 L315 Y324 Y334 G365 P370 E392 K393 D419 M420 E435 L436 L303 Y312 Y322 G353 P358 E380 K381 D407 M408 E423 L424 2.1.1.320 0000387,0000785,0002039,0003714,0005515,0005634,0005654,0005694,0005737,0005794,0005829,0006325,0006338,0006353,0006355,0006479,0007088,0008168,0008327,0008469,0010468,0016274,0018216,0032259,0032922,0032991,0034709,0035097,0035243,0035246,0042054,0042118,0042802,0043021,0044020,0044027,0044877,0045596,0045892,0046982,0048026,0048511,0048714,0070372,0070888,0090161,0097421,0140938,1901796,1904992 IC50=8600nM O14744 26985292 701 RVSSGRDLNCVPEIADTLGAVAKQGFDFLCMPVFHPRFKREFIQEPAKNRPGPQTRSDLLLSGRDWNTLIVGKLSPWIRPDSKVEKIRRNSEAAMLQELNFGAYLGLPAFLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAPEDLRDDIIENAPTTHTEEYSGEEKTWMWWHNFRTLCDYSKRIAVALEIGADLPSNHVIDRWLGEPIKAAILPTSIFLTNKKGFPVLSKMHQRLIFRLLKLEVQFIITGTNHHSEKEFCSYLQYLEYLSQNRPPPNAYELFAKGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKDTNVQVLMVLGAGRGPLVNASLRAAKQADRRIKLYAVEKNPNAVVTLENWQFEEWGSQVTVVSSDMREWVAPEKADIIVSELLGSFADNELSPECLDGAQHFLKDDGVSIPGEYTSFLAPISSSKLYNEVRACREKDRDPEAQFEMPYVVRLHNFHQLSAPQPCFTFSHPNRDPMIDNNRYCTLEFPVEVNTVLHGFAGYFETVLYQDITLSIRPETHSPGMFSWFPILFPIKQPITVREGQTICVRFWRCSNSKKVWYEWAVTAPVCSAIHNPTGRSYTIGL 5f8f A 1.9 BS01 SFG A 1 Y132 S146 F150 G179 G181 D202 F203 D229 L230 F245 D246 Q251 Y128 S142 F146 G175 G177 D198 F199 D225 L226 F241 D242 Q247 2.1.1.- 0005886,0008168,0009274,0032259,0071456 O53532 26772148 401 METTEEFGNRFVAAIDSAGLAILVSVGHQTGLLDTMAGLPPATSMEIAEAAGLEERYVREWLGGMTTGQIVEYDAGSSTYSLPAHRAGMLTRAAGPDNLAVIAQFVSLLGEVEQKVIRCFREGGGVPYSEYPRFHKLMAEMSGMVFDAALIDVVLPLVDGLPDRLRSGADVADFGCGSGRAVKLMAQAFGASRFTGIDFSDEAVAAGTEEAARLGLANATFERHDLAELDKVGAYDVITVFDAIHDQAQPARVLQNIYRALRPGGVLLMVDIKASSQLEDNVGVPLSTYLYTTSLMHCMTVSLALDGAGLGTVWGRQLATSMLADAGFTDVTVAEIESDVLNNYYIARKLEHH 5f8f B 1.9 BS01 SFG B 1 Y132 M142 S146 G179 D202 F203 D229 L230 F245 D246 Q251 Y138 M148 S152 G185 D208 F209 D235 L236 F251 D252 Q257 2.1.1.- 0005886,0008168,0009274,0032259,0071456 O53532 26772148 400 SSGLVPRGSHMETTEEFGNRFVAAIDSAGLAILVSVGHQTGLLDTMAGLPPATSMEIAEAAGLEERYVREWLGGMTTGQIVEYDAGSSTYSLPAHRAGMLTRAAGPDNLAVIAQFVSLLGEVEQKVIRCFREGGGVPYSEYPRFHKLMAEMSGMVFDAALIDVVLPLVDGLPDRLRSGADVADFGCGSGRAVKLMAQAFGASRFTGIDFSDEAVAAGTEEAARLGLANATFERHDLAELDKVGAYDVITVFDAIHDQAQPARVLQNIYRALRPGGVLLMVDIKASSQLEDNVGVPLSTYLYTTSLMHCMTVSLALDGAGLGTVWGRQLATSMLADAGFTDVTVAEIESDVLNNYYIARKLE 5f8f C 1.9 BS01 SFG C 1 Y132 S146 F150 G179 D202 F203 D229 L230 F245 D246 Q251 Y128 S142 F146 G175 D198 F199 D225 L226 F241 D242 Q247 2.1.1.- 0005886,0008168,0009274,0032259,0071456 O53532 26772148 400 METTEEFGNRFVAAIDSAGLAILVSVGHQTGLLDTMAGLPPATSMEIAEAAGLEERYVREWLGGMTTGQIVEYDAGSSTYSLPAHRAGMLTRAAGPDNLAVIAQFVSLLGEVEQKVIRCFREGGGVPYSEYPRFHKLMAEMSGMVFDAALIDVVLPLVDGLPDRLRSGADVADFGCGSGRAVKLMAQAFGASRFTGIDFSDEAVAAGTEEAARLGLANATFERHDLAELDKVGAYDVITVFDAIHDQAQPARVLQNIYRALRPGGVLLMVDIKASSQLEDNVGVPLSTYLYTTSLMHCMTVSLALDGAGLGTVWGRQLATSMLADAGFTDVTVAEIESDVLNNYYIARKLEHHH 5g02 A 2.451 BS01 SFG A 1 Y80 F81 Y84 M93 R99 G123 C124 V128 E146 A147 R173 A174 E175 E189 M200 S203 Y9 F10 Y13 M22 R28 G52 C53 V57 E75 A76 R102 A103 E104 E118 M129 S132 D96 E189 E198 H347 D25 E118 E127 H276 2.1.1.125 0016274,0018216 A1L1Q4 27879050 410 EDAWQDDEYFGNYGTLRLHLEMLSDKPRTETYRQVILSNSAALREKVVLDLGCGTGVISLFCALLAKPAGVYAVEASSMAEHTEELVKQNGCDGVVTVFQERAENLTLPTKVDVLVSEWMGNCLLFEYMLESVLLARDRWLKKGGMMWPSSACLTIVPCQAFSDYRQKVEFWENPYGLNFSYLQSLAQKEFLSKPKFSHHLQPEDCLSTPADVITLDMVTIQVSDLERLKGEFTFTVEKSGMFHGFTVWFSAHFQCLEEDGPSIELNTGPYSEITHWKQTLFMLDAPVSVEEGDIIAGSIRLQRNPIWRRHLSITFLWNINSTEVSTVKTKCFPMWR 5gm8 A 2.2 BS01 SFG A 1 T79 S80 A81 R82 F114 G115 R116 E117 H134 I135 L144 A149 T82 S83 A84 R85 F117 G118 R119 E120 H137 I138 L147 A152 2.1.1.200 0003723,0006396,0008173 A0A072ZPM2 27683218 500 QSMMLDRIRVVLVNTSHPGNIGGAARAMKNMGLSQLVLVQPESFPHGDAVARASGATDILDAARVVDTLEEALSGCSVVLGTSARDRRIPWPLLDPRECATTCLEHLEANGEVALVFGREYAGLTNEELQRCQFHVHIPSDPEFGSLNLAAAVQVLTYEVRMAWLAAQGK 5gm8 B 2.2 BS01 SFG B 1 T79 S80 A81 R82 F114 G115 R116 E117 Y118 G120 H134 I135 S143 L144 A149 T85 S86 A87 R88 F120 G121 R122 E123 Y124 G126 H140 I141 S149 L150 A155 2.1.1.200 0003723,0006396,0008173 A0A072ZPM2 27683218 500 LYFQSMMLDRIRVVLVNTSHPGNIGGAARAMKNMGLSQLVLVQPESFPHGDAVARASGATDILDAARVVDTLEEALSGCSVVLGTSARDRRIPWPLLDPRECATTCLEHLEANGEVALVFGREYAGLTNEELQRCQFHVHIPSDPEFGSLNLAAAVQVLTYEVRMAWLAAQGK 5gm8 C 2.2 BS01 SFG C 1 T79 S80 A81 R82 F114 G115 R116 E117 Y118 G120 H134 I135 S143 L144 A149 T82 S83 A84 R85 F117 G118 R119 E120 Y121 G123 H137 I138 S146 L147 A152 2.1.1.200 0003723,0006396,0008173 A0A072ZPM2 27683218 500 QSMMLDRIRVVLVNTSHPGNIGGAARAMKNMGLSQLVLVQPESFPHGDAVARASGATDILDAARVVDTLEEALSGCSVVLGTSARDRRIPWPLLDPRECATTCLEHLEANGEVALVFGREYAGLTNEELQRCQFHVHIPSDPEFGSLNLAAAVQVLTYEVRMAWLAAQGK 5gm8 D 2.2 BS01 SFG D 1 T79 S80 A81 F114 G115 R116 E117 Y118 G120 H134 I135 S143 L144 T83 S84 A85 F118 G119 R120 E121 Y122 G124 H138 I139 S147 L148 2.1.1.200 0003723,0006396,0008173 A0A072ZPM2 27683218 500 FQSMMLDRIRVVLVNTSHPGNIGGAARAMKNMGLSQLVLVQPESFPHGDAVARASGATDILDAARVVDTLEEALSGCSVVLGTSARDRRIPWPLLDPRECATTCLEHLEANGEVALVFGREYAGLTNEELQRCQFHVHIPSDPEFGSLNLAAAVQVLTYEVRMAWLAAQGK 5hr4 C 2.5964 BS04 SFG C 1 L311 G312 H314 Y315 T316 A363 C364 G365 C366 N368 F369 E413 I414 N460 A461 N481 P483 L155 G156 H158 Y159 T160 A207 C208 G209 C210 N212 F213 E257 I258 N304 A305 N325 P327 2.1.1.72 0008168,0032259,0046872 B2MU09 27082731 1002 PQDPINIKAAERMGKLHDTLKLVGYEGHALELYLVRLLFCLFAEDTTIFEKSLFQEYIETKTLEDGSDLAHHINTLFYVLNTPEQKRLKNLDEHLAAFPYINGKLFEEPLPPAQFDKAMREALLDLCSLDWSRISPAIFGSLFQSIMDAKKRRNLGAHYTSEANILKLIKPLFLDELWVEFEKVKNNKNKLLAFHKKLRGLTFFDPACGCGNFLVITYRELRLLEIEVLRGLHRGGQQVLDIEHLIQINVDQFFGIEIEEFPAQIAQVALWLTDHQMNMKISDEFGNYFARIPLKSTPHILNANALQIDWNDVLEAKKCCFILGNPPFVGKSKQTPGQKADLLSVFGNLKSASDLDLVAAWYPKAAHYIQTNANIRCAFVSTNSITQGEQVSLLWPLLLSLGIKINFAHRTFSWTNEASGVAAVHCVIIGFGLKDSDEKIIYEYESINGEPLAIKAKNINPYLRDGVDVIACKRQQPISKLPSMRYGNKPTDDGNFLFTDEEKNQFITNEPSSEKYFRRFVGGDEFINNTSRWCLWLDGADISEIRAMPLVLARIKKVQEFRLKSSAKPTRQSASTPMKFFYISQPDTDYLLIPETSSENRQFIPIGFVDRNVISSNATYHIPSAEPLIFGLLSSTMHNCWMRNVGGRLESRYRYSASLVYNTFPWIQPNEKQSKAIEEAAFAILKARSNYPNESLAGLYDPKTMPSELLKAHQKLDKAVDSVYGFKGPNTEIARIAFLFETYQKMTSL 5hr4 J 2.5964 BS04 SFG J 1 L311 G312 H314 Y315 T316 A363 C364 G365 C366 N368 F369 E413 I414 N460 A461 N481 P483 L156 G157 H159 Y160 T161 A208 C209 G210 C211 N213 F214 E258 I259 N305 A306 N326 P328 2.1.1.72 0008168,0032259,0046872 B2MU09 27082731 1002 KPQDPINIKAAERMGKLHDTLKLVGYEGHALELYLVRLLFCLFAEDTTIFEKSLFQEYIETKTLEDGSDLAHHINTLFYVLNTPEQKRLKNLDEHLAAFPYINGKLFEEPLPPAQFDKAMREALLDLCSLDWSRISPAIFGSLFQSIMDAKKRRNLGAHYTSEANILKLIKPLFLDELWVEFEKVKNNKNKLLAFHKKLRGLTFFDPACGCGNFLVITYRELRLLEIEVLRGLHRGGQQVLDIEHLIQINVDQFFGIEIEEFPAQIAQVALWLTDHQMNMKISDEFGNYFARIPLKSTPHILNANALQIDWNDVLEAKKCCFILGNPPFVGKSKQTPGQKADLLSVFGNLKSASDLDLVAAWYPKAAHYIQTNANIRCAFVSTNSITQGEQVSLLWPLLLSLGIKINFAHRTFSWTNEASGVAAVHCVIIGFGLKDSDEKIIYEYESINGEPLAIKAKNINPYLRDGVDVIACKRQQPISKLPSMRYGNKPTDDGNFLFTDEEKNQFITNEPSSEKYFRRFVGGDEFINNTSRWCLWLDGADISEIRAMPLVLARIKKVQEFRLKSSAKPTRQSASTPMKFFYISQPDTDYLLIPETSSENRQFIPIGFVDRNVISSNATYHIPSAEPLIFGLLSSTMHNCWMRNVGGRLESRYRYSASLVYNTFPWIQPNEKQSKAIEEAAFAILKARSNYPNESLAGLYDPKTMPSELLKAHQKLDKAVDSVYGFKGPNTEIARIAFLFETYQKMTSLL 5is6 A 2.007 BS01 SFG A 1 Y150 F151 Y154 Q160 M163 R169 G193 C194 I198 L199 E215 A216 K242 E244 E258 M269 S272 Y15 F16 Y19 Q25 M28 R34 G58 C59 I63 L64 E80 A81 K107 E109 E123 M134 S137 D166 E258 E267 H415 D31 E123 E132 H280 2.1.1.319 0016274,0018216 Q9WVG6 507 SVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYT 5is6 B 2.007 BS01 SFG B 1 Y150 F151 Y154 M163 R169 G193 C194 I198 L199 E215 A216 K242 V243 E244 E258 M269 S272 Y16 F17 Y20 M29 R35 G59 C60 I64 L65 E81 A82 K108 V109 E110 E124 M135 S138 D166 E258 E267 H415 D32 E124 E133 H281 2.1.1.319 0016274,0018216 Q9WVG6 2006 RSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYT 5is6 C 2.007 BS02 SFG C 1 Y150 F151 Y154 M163 R169 G193 C194 G195 I198 L199 E215 A216 K242 E244 E258 M269 S272 Y15 F16 Y19 M28 R34 G58 C59 G60 I63 L64 E80 A81 K107 E109 E123 M134 S137 D166 E258 E267 H415 D31 E123 E132 H280 2.1.1.319 0016274,0018216 Q9WVG6 507 SVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRY 5is6 D 2.007 BS01 SFG D 1 Y150 F151 Y154 M163 R169 G193 C194 I198 L199 E215 A216 K242 V243 E244 E258 M269 S272 Y16 F17 Y20 M29 R35 G59 C60 I64 L65 E81 A82 K108 V109 E110 E124 M135 S138 D166 E258 E267 H415 D32 E124 E133 H281 2.1.1.319 0016274,0018216 Q9WVG6 504 RSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFR 5lt8 A 1.57 BS04 SFG A 1 K1560 G1561 W1562 H1603 Y1604 Y1605 R1625 F1626 N1628 H1629 Y1666 Q1676 C1678 F1679 L1689 K104 G105 W106 H147 Y148 Y149 R169 F170 N172 H173 Y210 Q213 C215 F216 L226 Y1579 Y1666 Y123 Y210 2.1.1.-,2.1.1.359 0005634,0016279,0042054,0046975 Q9BYW2 27571355 1804 GPSCVMDDFRDPQRWKECAKQGKMPCYFDLIEENVYLTERKQCECTPLSKDERAQGEIACGEDCLNRLLMIECSSRCPNGDYCSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYFMALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQAQKCFCGSANCRGYLG 5mrk A 1.9 BS01 SFG A 1 S56 G58 G81 G86 W87 T104 K105 H110 E111 V130 D131 V132 F133 D146 S52 G54 G77 G82 W83 T100 K101 H106 E107 V126 D127 V128 F129 D142 2.1.1.56,2.1.1.57,2.7.7.48,3.4.21.91,3.6.1.15,3.6.4.13 0004482,0004483,0008168,0032259 A0A024B7W1 28357511 301 GETLGEKWKARLNQMSALEFYSYKKSGITEVCREEARRALKDGVATGGHAVSRGSAKLRWLVERGYLQPYGKVIDLGCGRGGWSYYAATIRKVQEVKGYTKGGPGHEEPMLVQSYGWNIVRLKSGVDVFHMAAEPCDTLLCDIGESSSSPEVEEARTLRVLSMVGDWLEKRPGAFCIKVLCPYTSTMMETLERLQRRYGGGLVRVPLSRNSTHEMYWVSGAKSNTIKSVSTTSQLLLGRMDGPRRPVKYEEDVNLGSGTR 5mrk B 1.9 BS01 SFG B 1 S56 G81 G86 W87 T104 K105 H110 E111 V130 V132 F133 D146 S37 G62 G67 W68 T85 K86 H91 E92 V111 V113 F114 D127 2.1.1.56,2.1.1.57,2.7.7.48,3.4.21.91,3.6.1.15,3.6.4.13 0004482,0004483,0008168,0032259 A0A024B7W1 28357511 301 GETLGEKWKARLNQMSALEFYSYKKSGITEVCRHAVSRGSAKLRWLVERGYLQPYGKVIDLGCGRGGWSYYAATIRKVQEVKGYTKGGPGHEEPMLVQSYGWNIVRLKSGVDVFHMAAEPCDTLLCDIGESSSSPEVEEARTLRVLSMVGDWLEKRPGAFCIKVLCPYTSTMMETLERLQRRYGGGLVRVPLSRNSTHEMYWVSGAKSNTIKSVSTTSQLLLGRMDGPRRPVKYEEDVNLGSGTR 5ouf A 1.7 BS01 SFG A 1 Y98 G99 H100 V103 F104 S129 A130 F171 Q172 Y211 I212 A213 G242 V243 S244 T245 Y92 G93 H94 V97 F98 S123 A124 F165 Q166 Y205 I206 A207 G236 V237 S238 T239 2.1.1.- 0008168,0032259 A0A2R2JFI5 30151425 501 TKAGSLTIVGTGIESIGQMTLQALSYIEAAAKVFYCVIDPATEAFILTKNKNCVDLYQYYDNGKSRLNTYTQMSELMVREVRKGLDVVGVFYGHPGVFVNPSHRALAIAKSEGYRARMLPGVSAEDCLFADLCIDPSNPGCLTYEASDFLIRDRPVSIHSHLVLFQVGCVGIADFNFTGFDNNKFGVLVDRLEQEYGAEHPVVHYIAAMMPHQDPVTDKYTVAQLREPEIAKRVGGVSTFYIPPKARKASNLDIIRRLELLPAGQVPDKKARIYPANQWEPDVPEVEPYRPSDQAAIAQLADHAPPEQYQPLATSKAMSDVMTKLALDPKALADYKADHRAFAQSVPDLTPQERAALELGDSWAIRCAMKNMPSSLLDAAFPAVIVVGV 5twk A 2.1 BS01 SFG A 1 L72 D73 I74 G103 G104 G107 L122 S123 T126 L127 V132 L74 D75 I76 G105 G106 G109 L124 S125 T128 L129 V134 2.1.1.177 0005515,0005737,0006364,0008168,0031167,0032259,0042803,0043022,0070038,0070475 P0A8I8 28428565 201 HHVKLQLVAVGTKMPDWVQTGFTEYLRRFPKDMPFELIEIPAGKRGKNADIKRILDKEGEQMLAAAGKNRIVTLDIPGKPWDTPQLAAELERWKLDGRDVSLLIGGPEGLSPACKAAAEQSWSLSALTLPHPLVRVLVAESLYRAWSITTNHPYHRE 5twk B 2.1 BS01 SFG B 1 L72 D73 I74 G103 G107 L122 S123 L127 V132 L74 D75 I76 G105 G109 L124 S125 L129 V134 2.1.1.177 0005515,0005737,0006364,0008168,0031167,0032259,0042803,0043022,0070038,0070475 P0A8I8 28428565 201 HHVKLQLVAVGTKMPDWVQTGFTEYLRRFPKDMPFELIEIPAGKRGKNADIKRILDKEGEQMLAAAGKNRIVTLDIPGKPWDTPQLAAELERWKLDGRDVSLLIGGPEGLSPACKAAAEQSWSLSALTLPHPLVRVLVAESLYRAWSITTNHPYHRE 5twk C 2.1 BS01 SFG C 1 L72 D73 I74 G103 G107 L122 S123 T126 L127 V132 L74 D75 I76 G105 G109 L124 S125 T128 L129 V134 2.1.1.177 0005515,0005737,0006364,0008168,0031167,0032259,0042803,0043022,0070038,0070475 P0A8I8 28428565 201 HHVKLQLVAVGTKMPDWVQTGFTEYLRRFPKDMPFELIEIPAGKRGKNADIKRILDKEGEQMLAAAGKNRIVTLDIPGKPWDTPQLAAELERWKLDGRDVSLLIGGPEGLSPACKAAAEQSWSLSALTLPHPLVRVLVAESLYRAWSITTNHPYHRE 5twk D 2.1 BS01 SFG D 1 L72 D73 I74 G103 G104 P105 L122 S123 L127 L74 D75 I76 G105 G106 P107 L124 S125 L129 2.1.1.177 0005515,0005737,0006364,0008168,0031167,0032259,0042803,0043022,0070038,0070475 P0A8I8 28428565 201 HHVKLQLVAVGTKMPDWVQTGFTEYLRRFPKDMPFELIEIPAGKRGKNADIKRILDKEGEQMLAAAGKNRIVTLDIPGKPWDTPQLAAELERWKLDGRDVSLLIGGPEGLSPACKAAAEQSWSLSALTLPHPLVRVLVAESLYRAWSITTNHPYHRE 5w7s A 2.948 BS02 SFG A 1 F194 E211 A243 S245 H246 D269 L270 D292 F293 R309 R310 F183 E200 A232 S234 H235 D258 L259 D281 F282 R298 R299 ? 0008168,0008171,0009058,0032259 A0A1B2TT09 30141817 502 AQKIAVQKDVDEVVAAAQRFLHGSGDEAKVDLQKKASNLVQTIRGPIPAALSSMEDIVKVASLRTLFEAGVFHAMPKGGASMTASEISAQTGLDKGILIRLMRAVTPLGPFHEVGEEEYAHTPFSEAYLTADIAGCFPVMSNFIFGPVLQICDFLRQNNWKDAITTRNNPFTLAHNCPGETMFEHLYKNSKNVAPVTKAEAADVDQIAMDLYPWEERLSDAKGSNATLVDIAGSHGNGTRAIMALAPKLNGCRFIVQDLEPVIGEHSQALRAEGIEPQVYDFLKQEQPVHGASIYYFRRVFHDWPDLPEGKKILDNTRAAMSREHSRILIHDIIVPEIGATMSHAWQDLSLMAIGGMERTEKDFARLLDIAGLALVKVWRKPGDMMGIIEARLK 5wwr A 3.096 BS02 SFG A 1 C242 A243 A244 K248 D266 K271 G294 D323 C241 A242 A243 K247 D265 K270 G293 D318 2.1.1.- 0000049,0001510,0002946,0003723,0005737,0005829,0006400,0008168,0008173,0008757,0016428,0030488,0032259 Q8TEA1 28531330 501 SIFPKISLRPEVENYLKEGFMNKEIVTALGKQEAERKFETLLKHLSHPPSFTTVRVNTHLASVQHVKNLLLDELQKQFNGLSVPILQHPDLQDVLLIPVIGPRKNIKKQQCEAIVGAQCGNAVLRGAHVYAPGIVSASQFMKAGDVISVYSDIKGKCKKGAKEFDGTKVFLGNGISELSRKEIFSGLPELKGMGIRMTEPVYLSPSFDSVLPRYLFLQNLPSALVSHVLNPQPGEKILDLCAAPGGKTTHIAALMHDQGEVIALDKIFNKVEKIKQNALLLGLNSIRAFCFDGTKAVKLDMVGEPPFLPESFDRILLDAPCSGMGQRPNMACTWSVKEVASYQPLQRKLFTAAVQLLKPEGVLVYSTCTITLAENEEQVAWALTKFPCLQLQPQEPQIGGEGMRGAGLSCEQLKQLQRFDPSAVPLPDTDMDSLREARREDMLRLANKDSIGFFIAKFVKC 5wwr B 3.096 BS02 SFG B 1 C242 A244 G247 K248 D266 K267 K271 G294 D323 C241 A243 G246 K247 D265 K266 K270 G293 D314 2.1.1.- 0000049,0001510,0002946,0003723,0005737,0005829,0006400,0008168,0008173,0008757,0016428,0030488,0032259 Q8TEA1 28531330 501 SIFPKISLRPEVENYLKEGFMNKEIVTALGKQEAERKFETLLKHLSHPPSFTTVRVNTHLASVQHVKNLLLDELQKQFNGLSVPILQHPDLQDVLLIPVIGPRKNIKKQQCEAIVGAQCGNAVLRGAHVYAPGIVSASQFMKAGDVISVYSDIKGKCKKGAKEFDGTKVFLGNGISELSRKEIFSGLPELKGMGIRMTEPVYLSPSFDSVLPRYLFLQNLPSALVSHVLNPQPGEKILDLCAAPGGKTTHIAALMHDQGEVIALDKIFNKVEKIKQNALLLGLNSIRAFCFDGTKAVKLEPPFLPESFDRILLDAPCSGMGQRPNMACTWSVKEVASYQPLQRKLFTAAVQLLKPEGVLVYSTCTITLAENEEQVAWALTKFPCLQLQPQEPQIGGEGMRGAGLSCEQLKQLQRFDPSAVPLPDTDMDSLREARREDMLRLANKDSIGFFIAKFVKC 5wyr A 2.45 BS01 SFG A 1 Y91 L92 S93 P94 Q95 G118 Y120 E121 S137 I138 L143 G145 G146 P149 Y89 L90 S91 P92 Q93 G116 Y118 E119 S135 I136 L141 G143 G144 P147 P94 E121 R159 D174 P92 E119 R157 D166 2.1.1.228 0002939,0005737,0005829,0006400,0008033,0008168,0032259,0052906 -logKd/Ki=6.39, Kd=0.41uM Q02RL6 31399541 400 SMLWVGVVSIFPEMFRAISDYGITSRAVKQGLLTLTCWNPRVYTEDRHQTVDDRPFGGGPGMVMKIKPLEGALADARQAAGGRKAKVIYLSPQGRQLTQAGVRELAEEEALILIAGRYEGIDERFIEEHVDEEWSIGDYVLSGGELPAMVLVDAVTRLLPGALGEDSFTDGLLDCPHYTRPEVYADKRVPEVLLSGNHEHIRRWRLQQALGRTWERRADLLDSRSLSGEEQKLLAEYIRQRD 5wyr A 2.45 BS02 SFG B 1 S175 D182 S167 D174 P94 E121 R159 D174 P92 E119 R157 D166 2.1.1.228 0002939,0005737,0005829,0006400,0008033,0008168,0032259,0052906 -logKd/Ki=6.39, Kd=0.41uM Q02RL6 31399541 400 SMLWVGVVSIFPEMFRAISDYGITSRAVKQGLLTLTCWNPRVYTEDRHQTVDDRPFGGGPGMVMKIKPLEGALADARQAAGGRKAKVIYLSPQGRQLTQAGVRELAEEEALILIAGRYEGIDERFIEEHVDEEWSIGDYVLSGGELPAMVLVDAVTRLLPGALGEDSFTDGLLDCPHYTRPEVYADKRVPEVLLSGNHEHIRRWRLQQALGRTWERRADLLDSRSLSGEEQKLLAEYIRQRD 5wyr B 2.45 BS01 SFG A 1 D174 S175 D182 D172 S173 D180 P94 E121 R159 D174 P92 E119 R157 D172 2.1.1.228 0002939,0005737,0005829,0006400,0008033,0008168,0032259,0052906 -logKd/Ki=6.39, Kd=0.41uM Q02RL6 31399541 400 SMLWVGVVSIFPEMFRAISDYGITSRAVKQGLLTLTCWNPRVYTEDRHQTVDDRPFGGGPGMVMKIKPLEGALADARQAAGGRKAKVIYLSPQGRQLTQAGVRELAEEEALILIAGRYEGIDERFIEEHVDEEWSIGDYVLSGGELPAMVLVDAVTRLLPGALGHADSAEEDSFTDGLLDCPHYTRPEVYADKRVPEVLLSGNHEHIRRWRLQQALGRTWERRADLLDSRSLSGEEQKLLAEYIRQRD 5wyr B 2.45 BS02 SFG B 1 Y91 L92 S93 P94 G118 Y120 E121 I138 V142 L143 S144 G145 G146 P149 Y89 L90 S91 P92 G116 Y118 E119 I136 V140 L141 S142 G143 G144 P147 P94 E121 R159 D174 P92 E119 R157 D172 2.1.1.228 0002939,0005737,0005829,0006400,0008033,0008168,0032259,0052906 -logKd/Ki=6.39, Kd=0.41uM Q02RL6 31399541 400 SMLWVGVVSIFPEMFRAISDYGITSRAVKQGLLTLTCWNPRVYTEDRHQTVDDRPFGGGPGMVMKIKPLEGALADARQAAGGRKAKVIYLSPQGRQLTQAGVRELAEEEALILIAGRYEGIDERFIEEHVDEEWSIGDYVLSGGELPAMVLVDAVTRLLPGALGHADSAEEDSFTDGLLDCPHYTRPEVYADKRVPEVLLSGNHEHIRRWRLQQALGRTWERRADLLDSRSLSGEEQKLLAEYIRQRD 5yf1 A 2.399 BS01 SFG A 1 R167 Y181 G208 E229 W230 F296 C312 F313 F314 T317 Y324 Y386 R98 Y112 G139 E160 W161 F227 C243 F244 F245 T248 Y255 Y317 2.1.1.22 0008757 Q8N4J0 29463897 501 EEERLEREHFWKIINAFRYYGTSMHERVNRTERQFRSLPANQQKLLPQFLLHLDKIRKCIDHNQEILLTIVNDCIHKIMPASTFDMDKLKSTLKQFVRDWSETGKAERDACYQPIIKEILKNFPKERWDPSKVNILVPGAGLGRLAWEIAMLGYACQGNEWSFFMLFSSNFVLNRCSEINKYKLYPWIHQFSNNRRSADQIRPIFFPDVDPHSLPPGSNFSMTAGDFQEIYSECNTWDCIATCFFIDTAHNVIDYIDTIWKILKPGGIWINLGPLLYHFENLANELSIELSYEDIKNVVLQYGFKVEVEKESVLSTYTVNDLSMMKYYYECVLFVVRKPQ 5yf1 B 2.399 BS01 SFG B 1 R167 Y181 G208 E229 W230 F296 C312 F313 F314 T317 Y324 Y386 R109 Y123 G150 E171 W172 F238 C254 F255 F256 T259 Y266 Y328 2.1.1.22 0008757 Q8N4J0 29463897 501 EEEERLEREHFWKIINAFRYYGTSMHERVNRTERQFRSLPANQQKLLPQFLLHLDKIRKCIDHNQEILLTIVNDCIHMFENKEYGEGKIMPASTFDMDKLKSTLKQFVRDWSETGKAERDACYQPIIKEILKNFPKERWDPSKVNILVPGAGLGRLAWEIAMLGYACQGNEWSFFMLFSSNFVLNRCSEINKYKLYPWIHQFSNNRRSADQIRPIFFPDVDPHSLPPGSNFSMTAGDFQEIYSECNTWDCIATCFFIDTAHNVIDYIDTIWKILKPGGIWINLGPLLYHFENLANELSIELSYEDIKNVVLQYGFKVEVEKESVLSTYTVNDLSMMKYYYECVLFVVRKPQ 5ylt A 1.69 BS01 SFG A 1 A226 E228 G264 N265 H293 K294 N296 H297 Y335 W352 E356 A112 E114 G150 N151 H179 K180 N182 H183 Y221 W235 E239 Y245 H293 H297 Y305 Y335 Y131 H179 H183 Y191 Y221 2.1.1.364 0005694,0006355,0016279,0140945 IC50=2500nM Q8WTS6 29882380 401 RHGVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFIDGEMIEGKLATLMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYVAESLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFTPNCIYDMFVHPRFGPIKCIRTLRAVEADEELTVAYGYDHSPPGKSAPEWYQVELKAFQATQ 5ynb A 1.98 BS01 SFG A 1 N43 Y47 G71 G73 P80 D99 L100 D114 C115 D130 M131 Y132 N43 Y47 G71 G73 P80 D99 L100 D114 C115 D130 M131 Y132 2.1.1.57,3.4.19.12,3.6.4.12,3.6.4.13 0004483 K0BWD0 401 ASADWKPGHAMPSLFKVQNVNLERCELANYKQSIPMPRGVHMNIAKYMQLCQYLNTCTLAVPANMRVIHFGAGSDKGIAPGTSVLRQWLPTDAIIIDNDLNEFVSDADITLFGDCVTVRVGQQVDLVISDMYDPTGSNESKALFFTYLCNLINNNLALGGSVAIKITEHSWSVELYELMGKFAWWTVFCTNANASSSEGFLLGINYLGTIKENIDGGAMHANYIFWRNSTPMNLSTYSLFDLSKFQLKLKGTPVLQLKESQINELVISLLSQGKLLIRDNDTLSVSTDVLV 5ynn A 1.86 BS01 SFG A 1 N43 G71 G73 D99 L100 D114 C115 D130 M131 N43 G71 G73 D99 L100 D114 C115 D130 M131 2.1.1.57,3.4.19.12,3.6.4.12,3.6.4.13 0004483 K0BWD0 401 ASADWKPGHAMPSLFKVQNVNLERCELANYKQSIPMPRGVHMNIAKYMQLCQYLNTCTLAVPANMRVIHFGAGSDKGIAPGTSVLRQWLPTDAIIIDNDLNEFVSDADITLFGDCVTVRVGQQVDLVISDMYDPTTKNVTGSNESKALFFTYLCNLINNNLALGGSVAIKITEHSWSVELYELMGKFAWWTVFCTNANASSSEGFLLGINYLGTIKENIDGGAMHANYIFWRNSTPMNLSTYSLFDLSKFQLKLKGTPVLQLKESQINELVISLLSQGKLLIRDNDTLSVSTDVL 5ynp A 2.27 BS01 SFG A 1 N43 Y47 G71 G73 P80 D99 L100 D114 C115 D130 M131 Y132 N43 Y47 G71 G73 P80 D99 L100 D114 C115 D130 M131 Y132 2.1.1.57,3.4.19.12,3.6.4.12,3.6.4.13 0004483 K0BWD0 401 ASADWKPGHAMPSLFKVQNVNLERCELANYKQSIPMPRGVHMNIAKYMQLCQYLNTCTLAVPANMRVIHFGAGSDKGIAPGTSVLRQWLPTDAIIIDNDLNEFVSDADITLFGDCVTVRVGQQVDLVISDMYDPTTKNVTGSNESKALFFTYLCNLINNNLALGGSVAIKITEHSWSVELYELMGKFAWWTVFCTNANASSSEGFLLGINYLGTIKENIDGGAMHANYIFWRNSTPMNLSTYSLFDLSKFQLKLKGTPVLQLKESQINELVISLLSQGKLLIRDNDTLSVSTDV 5zvh A 2.5 BS01 SFG A 1 A209 A210 A211 P212 G214 K215 D233 K234 R238 D260 A261 D277 Y304 F308 A205 A206 A207 P208 G210 K211 D229 K230 R234 D256 A257 D273 Y300 F304 2.1.1.- 0000049,0001510,0003723,0006396,0006400,0008168,0008173,0008757,0016428,0016740,0032259 O57712 30541086 401 YLEAFPKELREYYKNLFGKEEANKIMKKLREPVEHYYIRVNTLKISREKLIGELKKEGLKPLRSPYLPEGLYFVREGPNFSDDFEPKLPVVVANKYAAESVYQGAMLYAPGVLKADKNIKEGDEVQIRDPKGLLVGIGIARMDYKEMTEATRGLAVEVTLPKFKLPSLSELKAFEKGYFYPQGLPSMVTARVLEPKEDDVIIDMAAAPGGKTTHIAQLLENKGEIIAIDKSKNRLRKMEENIKRLGVKNVKLVQMDARKLPDLGIKADKILLDAPCTALGVRPKLWEERTLKHIEATARYQRAFIWAAIKSLRRGGVLVYSTCTLSYEENEGNVKFMIRKGMKLEEQSIFIGSPGIGMNKVQRFYPHKHLTQGFFIAKLRKVKD 5zvh B 2.5 BS01 SFG B 1 A209 A210 A211 P212 G214 K215 D233 K234 R238 D260 A261 D277 Y304 F308 A205 A206 A207 P208 G210 K211 D229 K230 R234 D256 A257 D273 Y300 F304 2.1.1.- 0000049,0001510,0003723,0006396,0006400,0008168,0008173,0008757,0016428,0016740,0032259 O57712 30541086 401 YLEAFPKELREYYKNLFGKEEANKIMKKLREPVEHYYIRVNTLKISREKLIGELKKEGLKPLRSPYLPEGLYFVREGPNFSDDFEPKLPVVVANKYAAESVYQGAMLYAPGVLKADKNIKEGDEVQIRDPKGLLVGIGIARMDYKEMTEATRGLAVEVTLPKFKLPSLSELKAFEKGYFYPQGLPSMVTARVLEPKEDDVIIDMAAAPGGKTTHIAQLLENKGEIIAIDKSKNRLRKMEENIKRLGVKNVKLVQMDARKLPDLGIKADKILLDAPCTALGVRPKLWEERTLKHIEATARYQRAFIWAAIKSLRRGGVLVYSTCTLSYEENEGNVKFMIRKGMKLEEQSIFIGSPGIGMNKVQRFYPHKHLTQGFFIAKLRKVKD 6bdy A 1.512 BS01 SFG A 1 D946 R1134 P1135 A1136 Y1139 P1140 A1141 Y1189 D46 R234 P235 A236 Y239 P240 A241 Y289 2.1.1.13 0008705,0009086 Kd=2.04uM -logKd/Ki=5.69, Kd=2.04uM P13009 29733595 1301 TPPVTLEAARDNDFAFDWQAYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKYPRILEDEVVGVEAQRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVGDDIEIYRDETRTHVINVSHHLRQQTEKTGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAFEAQHDDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQGIRPAPGYPACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYAVAQIQRDQVEDYARRKGMSVTEVERWLAPNLGYDA 6gew A 2.1 BS02 SFG A 1 Y98 G99 H100 V103 F104 S129 A130 F171 Q172 I212 A213 G242 V243 S244 T245 Y92 G93 H94 V97 F98 S123 A124 F165 Q166 I206 A207 G236 V237 S238 T239 2.1.1.- 0008168,0032259 A0A2R2JFI5 30151425 502 TKAGSLTIVGTGIESIGQMTLQALSYIEAAAKVFYCVIDPATEAFILTKNKNCVDLFQYYDNGKSRLNTYTQMSELMVREVRKGLDVVGVFYGHPGVFVNPSHRALAIAKSEGYRARMLPGVSAEDCLFADLCIDPSNPGCLTYEASDFLIRDRPVSIHSHLVLFQVGCVGIADFNFTGFDNNKFGVLVDRLEQEYGAEHPVVHYIAAMMPHQDPVTDKYTVAQLREPEIAKRVGGVSTFYIPPKARKASNLDIIRRLELRIYPANQWEPDVPEVEPYRPSDQAAIAQLADHAPPEQYQPLATSKAMSDVMTKLALDPKALADYKADHRAFAQSVPDLTPQERAALELGDSWAIRCAMKNMPSSLLDFPWVIVVGV 6i3d A 1.45 BS03 SFG A 1 M40 N41 V42 G66 Y68 Y71 S72 E90 I91 S119 D141 H142 W143 M39 N40 V41 G65 Y67 Y70 S71 E89 I90 S118 D140 H141 W142 2.1.1.6 0000287,0006584,0008171,0016206 P21964 31080692 303 GDTKEQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFECTHYQSFLEYREVVDGLEKAIYKGP 6i3d B 1.45 BS03 SFG B 1 M40 N41 V42 G66 Y68 Y71 S72 E90 I91 S119 D141 H142 W143 M44 N45 V46 G70 Y72 Y75 S76 E94 I95 S123 D145 H146 W147 2.1.1.6 0000287,0006584,0008171,0016206 P21964 31080692 303 NLYFQGDTKEQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFECTHYQSFLEYREVVDGLEKAIYKG 6jat A 2.713 BS02 SFG A 1 R74 E103 F105 P179 T252 R253 D274 M275 N277 H278 Y312 S324 F326 R55 E84 F86 P160 T233 R234 D255 M256 N258 H259 Y293 S305 F307 2.1.1.85 0018064,0030047 Q86TU7 501 SPKEILNLTSELLQKCSSPAPGPGKEWEEYVQIRTLVEKIRKKQKGLSVTFDGKREDYFPDLMKWASENGASVEGFEMVNFKEEGFGLRATRDIKAEELFLWVPRKLLMTVESAKNSVLGPLYSQDRILQAMGNIALAFHLLCERASPNSFWQPYIQTLPSEYDTPLYFEEDEVRYLQSTQAIHDVFSQYKNTARQYAYFYKVIQTHPHANKLPLKDSFTYEDYRWAVSSVMTRQNQIPTEDGSRVTLALIPLWDMCNHTNGLITTGYNLEDDRCECVALQDFRAGEQIYIFYGTRSNAEFVIHSGFFFDNNSHDRVKIKLGVSKSDRLYAMKAEVLARAGIPTSSVFALHFTEPPISAQLLAFLRVFCMTEEELKEHLLGDSAIDRIFTLGNSEFPVSWDNEVKLWTFLEDRASLLLKTYKTTIEEDKSVLKNHDLSVRAKMAIKLRLGEKEILEKAVKSAAVNREYYRQQMEE 6jat C 2.713 BS02 SFG C 1 R74 E103 F105 R253 D274 M275 N277 H278 Y312 S324 F326 F328 R55 E84 F86 R234 D255 M256 N258 H259 Y293 S305 F307 F309 2.1.1.85 0018064,0030047 Q86TU7 501 SPKEILNLTSELLQKCSSPAPGPGKEWEEYVQIRTLVEKIRKKQKGLSVTFDGKREDYFPDLMKWASENGASVEGFEMVNFKEEGFGLRATRDIKAEELFLWVPRKLLMTVESAKNSVLGPLYSQDRILQAMGNIALAFHLLCERASPNSFWQPYIQTLPSEYDTPLYFEEDEVRYLQSTQAIHDVFSQYKNTARQYAYFYKVIQTHPHANKLPLKDSFTYEDYRWAVSSVMTRQNQIPTEDGSRVTLALIPLWDMCNHTNGLITTGYNLEDDRCECVALQDFRAGEQIYIFYGTRSNAEFVIHSGFFFDNNSHDRVKIKLGVSKSDRLYAMKAEVLARAGIPTSSVFALHFTEPPISAQLLAFLRVFCMTEEELKEHLLGDSAIDRIFTLGNSEFPVSWDNEVKLWTFLEDRASLLLKTYKTTIEEDKSVLKNHDLSVRAKMAIKLRLGEKEILEKAVKSAAVNREYYRQQ 6jki A 2.59 BS01 SFG A 1 Y91 L92 S93 P94 G118 Y120 E121 I138 L143 G145 G146 P149 Y89 L90 S91 P92 G116 Y118 E119 I136 L141 G143 G144 P147 P94 E121 R159 D174 P92 E119 R157 D165 2.1.1.228 0002939,0005737,0005829,0006400,0008033,0008168,0032259,0052906 -logKd/Ki=6.39, Kd=0.41uM Q9HXQ1 31399541 301 SMLWVGVVSIFPEMFRAISDYGITSRAVKQGLLTLTCWNPRVYTEDRHQTVDDRPFGGGPGMVMKIKPLEGALADARQAAGGRKAKVIYLSPQGRQLTQAGVRELAEEEALILIAGRYEGIDERFIEEHVDEEWSIGDYVLSGGELPAMVLVDAVTRLLPGALEDSFTDGLLDCPHYTRPEVYADKRVPEVLLSGNHEHIRRWRLQQALGRTWERRADLLDSRSLSGEEQKLLAEYIRQRD 6jki A 2.59 BS02 SFG A 2 S175 D182 S166 D173 P94 E121 R159 D174 P92 E119 R157 D165 2.1.1.228 0002939,0005737,0005829,0006400,0008033,0008168,0032259,0052906 -logKd/Ki=6.39, Kd=0.41uM Q9HXQ1 31399541 306 SMLWVGVVSIFPEMFRAISDYGITSRAVKQGLLTLTCWNPRVYTEDRHQTVDDRPFGGGPGMVMKIKPLEGALADARQAAGGRKAKVIYLSPQGRQLTQAGVRELAEEEALILIAGRYEGIDERFIEEHVDEEWSIGDYVLSGGELPAMVLVDAVTRLLPGALEDSFTDGLLDCPHYTRPEVYADKRVPEVLLSGNHEHIRRWRLQQALGRTWERRADLLDSRSLSGEEQKLLAEYIRQRD 6jki B 2.59 BS01 SFG A 1 D174 S175 D182 D168 S169 D176 P94 E121 R159 D174 P92 E119 R157 D168 2.1.1.228 0002939,0005737,0005829,0006400,0008033,0008168,0032259,0052906 -logKd/Ki=6.39, Kd=0.41uM Q9HXQ1 31399541 301 SMLWVGVVSIFPEMFRAISDYGITSRAVKQGLLTLTCWNPRVYTEDRHQTVDDRPFGGGPGMVMKIKPLEGALADARQAAGGRKAKVIYLSPQGRQLTQAGVRELAEEEALILIAGRYEGIDERFIEEHVDEEWSIGDYVLSGGELPAMVLVDAVTRLLPGALSAEEDSFTDGLLDCPHYTRPEVYADKRVPEVLLSGNHEHIRRWRLQQALGRTWERRADLLDSRSLSGEEQKLLAEYIRQRD 6jki B 2.59 BS02 SFG A 2 L92 S93 P94 G118 Y120 E121 I138 L143 G145 G146 P149 L90 S91 P92 G116 Y118 E119 I136 L141 G143 G144 P147 P94 E121 R159 D174 P92 E119 R157 D168 2.1.1.228 0002939,0005737,0005829,0006400,0008033,0008168,0032259,0052906 -logKd/Ki=6.39, Kd=0.41uM Q9HXQ1 31399541 306 SMLWVGVVSIFPEMFRAISDYGITSRAVKQGLLTLTCWNPRVYTEDRHQTVDDRPFGGGPGMVMKIKPLEGALADARQAAGGRKAKVIYLSPQGRQLTQAGVRELAEEEALILIAGRYEGIDERFIEEHVDEEWSIGDYVLSGGELPAMVLVDAVTRLLPGALSAEEDSFTDGLLDCPHYTRPEVYADKRVPEVLLSGNHEHIRRWRLQQALGRTWERRADLLDSRSLSGEEQKLLAEYIRQRD 6k0w A 2.65 BS01 SFG A 1 D82 N83 D104 P380 K381 F406 G408 S409 T411 Q433 I434 D48 N49 D70 P329 K330 F355 G357 S358 T360 Q382 I383 ? 0003676,0003677,0005737,0008168,0008170,0009007,0032259 O25315 31628946 701 GYELTWTGKGFANALYSEPCQKQLKLQESFTPQTSASKHPNNAIIIGDNLDALKLLKSAYSEKIKMIYIDPPYNTGNDEFIYPDNFRQDYQKILREESESLKFFKNTQGSGTHSGWLSFMLPRLKLARDLLKEDGVIFISIDDNECANLKILCDEIFGEDNFVGDFIRKTKSTTNDAKIGLNYQHEFLLCYAKDKNYTNLLGGEKNLEPDNDPNGAWINDNPSAKSGNMKTGYFGVTNPYTNKVDYPPVGMFWRFSQNTIQKHIDEGRICFKKEHKDNERGFIYKRYLKDLKTTQKTFDSLIFSDNCYMNQAATKELLNLGMGEYFTYPKGVEFMKKIILHSTTPNEGDIILDFFAGSGTTVHAVMELNAEDKGNREFILVQIDEEIKEDESAYDFCKKELKSAKPVISDITIERVKRAAQKISQLSKDSGLDLGFKVYTLQDKSDLTPFDKALNLALQCGKTLNQALEIIIKDKLYKCEDAYFCIVCDEEAQEYLAKSKNEMIFLDGYEEIDLEAFLNLNASFKERL 6k0w B 2.65 BS01 SFG B 1 D82 N83 D104 P380 F406 A407 G408 S409 T411 Q433 I434 D65 N66 D87 P300 F326 A327 G328 S329 T331 Q353 I354 ? 0003676,0003677,0005737,0008168,0008170,0009007,0032259 O25315 31628946 601 VSLSAIKMLLGFNESMNDISGYELTWTGKGFANALYSEPCQKQLKLQESFTPQTSHPNNAIIIGDNLDALKLLKSAYSEKIKMIYIDPPYNTGNDEFIYPDNFRQDYQKILREVGESLKFFKNTQGSGTHSGWLSFMLPRLKLARDLLKEDGVIFISIDDNECANLKILCDEIFGEDNFVGDFIRKTKSTTNDAKIGLNYQHEFLLCYAKDKNYTNLLGNDPNGAWINDNPSAKSGNMKTGYFGVTNKVDYPPVGMFWRFSQKTTQKTFDSLIFSDNCYMNQAATKELLNLGMGEYFTYPKGVEFMKKIILHSTTPNEGDIILDFFAGSGTTVHAVMELNAEDKGNREFILVQIDEEIKEDESAYDFCKKELKSAKPVISDITIERVKRAAQKISQLSKDSGLDLGFKVYTLQDKSDLTPFDKALNLALQCGKTLNQALEIIIKDKLYKCEDAYFCIVCDEEAQEYLAKSKNEMIFLDGYEEIDLEAFLNLNASFKERL 6k0w C 2.65 BS01 SFG C 1 D82 N83 D104 K381 F406 A407 S409 T411 Q433 I434 D45 N46 D67 K239 F264 A265 S267 T269 Q291 I292 ? 0003676,0003677,0005737,0008168,0008170,0009007,0032259 O25315 31628946 801 GYELTWTGKGFANALYSEPCQKQLKLQESFTPQSKHPNNAIIIGDNLDALKLLKSAYSEKIKMIYIDPPYNTGNDEFIYPDNFRQDYQKILREVSESLKFFKNTQGSGTHSGWLSFMLPRLKLARDLLKEDGVIFISIDDNECANLKILCDEIFGEDNFVGDFIRKTKSTTNDAKIGLNYQHEFLLCYAKDKNYTNLLGGEKNQKTFDSLIFSDNCYMNQAATKELLNLGMGEYFTYPKGVEFMKKIILHSTTPNEGDIILDFFAGSGTTVHAVMELNAEDKGNREFILVQIDEEIKEDESAYDFCKKELKSAKPVISDITIERVKRAAQKISQLSKDSGLDLGFKVYTLQDDLTPFDKALNLALQCGKTLNQALEIIIKDKLYKCEDAYFCIVCDEEAQEYLAKSKNEMIFLDGYEELEAFLNLNASFKERL 6k0w D 2.65 BS01 SFG D 1 D82 N83 D104 F377 K381 F406 G408 S409 T411 Q433 I434 D66 N67 D88 F257 K261 F286 G288 S289 T291 Q313 I314 ? 0003676,0003677,0005737,0008168,0008170,0009007,0032259 O25315 31628946 901 LSAIKMLLGFNESMNDISGYELTWTGKGFANALYSEPCQKQLKLQESFTPQTSASKHPNNAIIIGDNLDALKLLKSAYSEKIKMIYIDPPYNTGNDEFIYPDNFRQDYQKILREVGESESLKFFKNTQGSGTHSGWLSFMLPRLKLARDLLKEDGVIFISIDDNECANLKILCDEIFGEDNFVGDFIRKTKSTTNDAKIGLNYQHEFLLCYAKDKNYTNLLGGEKQKTFDSLIFSDNCYMNQAATKELLNLGMGEYFTYPKGVEFMKKIILHSTTPNEGDIILDFFAGSGTTVHAVMELNAEDKGNREFILVQIDEEIKEDESAYDFCKKELKSAKPVISDITIERVKRAAQKISQLSKDSGLDLGFKVYTLQDKVSDLTPFDKALNLALQCGKTLNQALIKDKLYKCEDAFCIVCDEEAQEYLKSKNEMIFLDG 6m1c A 2.401 BS01 SFG A 1 P23 T24 Y51 A52 G53 S54 E73 S74 V101 D119 P121 P22 T23 Y50 A51 G52 S53 E72 S73 V100 D118 P120 2.1.1.-,2.1.1.171 0003676,0005576,0006364,0008168,0030430,0031167,0032259,0042025,0044196 I6XFS7 401 SMTRIIGGVAGGRRIAVPPTRPTTDRVRESLFNIVTARRDLTGLAVLDLYAGSGALGLEALSRGAASVLFVESDQRSAAVIARNIEALGLSGATLRRGAVAAVVAAGTTSPVDLVLADPPYNVDSADVDAILAALGTNGWTREGTVAVVERATTCAPLTWPEGWRRWPQRVYGDTRLELAERLF 6ox0 A 1.755 BS02 SFG A 1 R74 E103 F105 R253 D274 M275 N277 H278 Y312 S324 F326 R55 E84 F86 R234 D255 M256 N258 H259 Y293 S305 F307 2.1.1.85 0000785,0003713,0003779,0005515,0005634,0005654,0005737,0006338,0008168,0008170,0008276,0008757,0016279,0018021,0018023,0018064,0030047,0032259,0042800,0045893,0045944,0046975,0051149,0061629,0070472 -logKd/Ki=4.85, Ki=14uM Q86TU7 31388018 1001 SPKEILNLTSELLQKCSSPAPGPGKEWEEYVQIRTLVEKIRKKQKGLSVTFDGKREDYFPDLMKWASENGASVEGFEMVNFKEEGFGLRATRDIKAEELFLWVPRKLLMTVESAKNSVLGPLYSQDRILQAMGNIALAFHLLCERASPNSFWQPYIQTLPSEYDTPLYFEEDEVRYLQSTQAIHDVFSQYKNTARQYAYFYKVIQTHPHANKLPLKDSFTYEDYRWAVSSVMTRQNQIPTEDGSRVTLALIPLWDMCNHTNGLITTGYNLEDDRCECVALQDFRAGEQIYIFYGTRSNAEFVIHSGFFFDNNSHDRVKIKLGVSKSDRLYAMKAEVLARAGIPTSSVFALHFTEPPISAQLLAFLRVFCMTEEELKEHLLGDSAIDRIFTLGNSEFPVSWDNEVKLWTFLEDRASLLLKTYKTTIEEDKSVLKNHDLSVRAKMAIKLRLGEKEILEKAVKSAAVNREYYRQQMEEKAPLPK 6ox0 B 1.755 BS02 SFG B 1 R74 E103 F105 R253 D274 M275 N277 H278 Y312 S324 F326 R56 E85 F87 R235 D256 M257 N259 H260 Y294 S306 F308 2.1.1.85 0000785,0003713,0003779,0005515,0005634,0005654,0005737,0006338,0008168,0008170,0008276,0008757,0016279,0018021,0018023,0018064,0030047,0032259,0042800,0045893,0045944,0046975,0051149,0061629,0070472 Q86TU7 31388018 1001 VSPKEILNLTSELLQKCSSPAPGPGKEWEEYVQIRTLVEKIRKKQKGLSVTFDGKREDYFPDLMKWASENGASVEGFEMVNFKEEGFGLRATRDIKAEELFLWVPRKLLMTVESAKNSVLGPLYSQDRILQAMGNIALAFHLLCERASPNSFWQPYIQTLPSEYDTPLYFEEDEVRYLQSTQAIHDVFSQYKNTARQYAYFYKVIQTHPHANKLPLKDSFTYEDYRWAVSSVMTRQNQIPTEDGSRVTLALIPLWDMCNHTNGLITTGYNLEDDRCECVALQDFRAGEQIYIFYGTRSNAEFVIHSGFFFDNNSHDRVKIKLGVSKSDRLYAMKAEVLARAGIPTSSVFALHFTEPPISAQLLAFLRVFCMTEEELKEHLLGDSAIDRIFTLGNSEFPVSWDNEVKLWTFLEDRASLLLKTYKTTIEEDKSVLKNHDLSVRAKMAIKLRLGEKEILEKAVKSAAVNREYYRQQMEEKAPLPKY 6pbd A 2.343 BS03 SFG A 1 D12 C13 D31 W57 H189 T191 F216 V219 T221 E237 R238 Y242 D12 C13 D31 W57 H189 T191 F216 V219 T221 E237 R238 Y242 2.1.1.72 0003676,0003677,0005737,0006260,0008168,0008170,0009007,0032259 P0CAW2 31601797 501 MKFGPETIIHGDCIEQMNALPEKSVDLIFADPPYNLQLGGDLLRPDNSKVDAVDDHWDQFESFAAYDKFTREWLKAARRVLKDDGAIWVIGSYHNIFRVGVAVQDLGFWILNDIVWRKSNPMPNFKGTRFANAHETLIWASKSQNAKRYTFNYDALKMANDEVQMRSDWTIPLCTGEERIKGADGQKAHPTQKPEALLYRVILSTTKPGDVILDPFFGVGTTGAAAKRLGRKFIGIEREAEYLEHAKARIAKVVPIAPEDRAEPRVPFGTIVEAGLLSPGDTLYCSKGTHVAKVRPDGSITVGDLSGSIHKIGALVQSAPACNGWTYWHFKTDAGLAPIDVLRAQVRAGM 6pbd B 2.343 BS03 SFG B 1 D12 C13 D31 H189 T191 F216 V219 T221 E237 R238 Y242 D10 C11 D29 H164 T166 F191 V194 T196 E212 R213 Y217 2.1.1.72 0003676,0003677,0005737,0006260,0008168,0008170,0009007,0032259 P0CAW2 31601797 601 FGPETIIHGDCIEQMNALPEKSVDLIFADPPYNLQLSFAAYDKFTREWLKAARRVLKDDGAIWVIGSYHNIFRVGVAVQDLGFWILNDIVWRKSNPMPNFKGTRFANAHETLIWASKSQNAKRYTFNYDALKMANDEVQMRSDWTIPLCTGEERIKGADGQKAHPTQKPEALLYRVILSTTKPGDVILDPFFGVGTTGAAAKRLGRKFIGIEREAEYLEHAKARIAKVVPIAPEDLDVMGSKRAEPRVPFGTIVEAGLLSPGDTLYCSKGTHVAKVRPDGSITVGDLSGSIHKIGALVQSAPACNGWTYWHFKTDAGLAPIDVLRAQVRAG 6v0n A 2.11 BS02 SFG A 1 P314 L315 Y324 Y334 G365 P370 E392 K393 D419 M420 E435 L436 C449 P301 L302 Y311 Y321 G352 P357 E379 K380 D406 M407 E422 L423 C436 2.1.1.320 0000387,0000785,0002039,0003714,0005515,0005634,0005654,0005694,0005737,0005794,0005829,0006325,0006338,0006353,0006355,0006479,0007088,0008168,0008327,0008469,0010468,0016274,0018216,0032259,0032922,0032991,0034709,0035097,0035243,0035246,0042054,0042118,0042802,0043021,0044020,0044027,0044877,0045596,0045892,0046982,0048026,0048511,0048714,0070372,0070888,0090161,0097421,0140938,1901796,1904992 IC50=8600nM O14744 34358446 701 VSSGRDLNCVPEIADTLGAVAKQGFDFLCMPVFHPRFKREFIQEPAKNRPGPQTRSDLLLSGRDWNTLIVGKLSPWIRPDSKVEKIRRNSEAAMLQELNFGAYLGLPAFLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAPEDLRDDIIENAPTTHTEEYSGEEKTWMWWHNFRTLCDYSKRIAVALEIGADLPSNHVIDRWLGEPIKAAILPTSIFLTNKKGFPVLSKMHQRLIFRLLKLEVQFIITGTNHHSEKEFCSYLQYLEYLSQNRPPPNAYELFAKGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKDTNVQVLMVLGAGRGPLVNASLRAAKQADRRIKLYAVEKNPNAVVTLENWQFEEWGSQVTVVSSDMREWVAPEKADIIVSELLGSFADNELSPECLDGAQHFLKDDGVSIPGEYTSFLAPISSSKLYNEVRACREKDRDPEAQFEMPYVVRLHNFHQLSAPQPCFTFSHPNRDPMIDNNRYCTLEFPVEVNTVLHGFAGYFETVLYQDITLSIRPETHSPGMFSWFPILFPIKQPITVREGQTICVRFWRCSNSKKVWYEWAVTAPVCSAIHNPTGRSYTIGL 6v0o A 2.86 BS02 SFG A 1 L315 Y324 Y334 G365 P370 L371 E392 K393 D419 M420 E435 L436 C449 L303 Y312 Y322 G353 P358 L359 E380 K381 D407 M408 E423 L424 C437 2.1.1.320 0000387,0000785,0002039,0003714,0005515,0005634,0005654,0005694,0005737,0005794,0005829,0006325,0006338,0006353,0006355,0006479,0007088,0008168,0008327,0008469,0010468,0016274,0018216,0032259,0032922,0032991,0034709,0035097,0035243,0035246,0042054,0042118,0042802,0043021,0044020,0044027,0044877,0045596,0045892,0046982,0048026,0048511,0048714,0070372,0070888,0090161,0097421,0140938,1901796,1904992 IC50=8600nM O14744 34358446 701 RVSSGRDLNCVPEIADTLGAVAKQGFDFLCMPVFHPRFKREFIQEPAKNRPGPQTRSDLLLSGRDWNTLIVGKLSPWIRPDSKVEKIRRNSEAAMLQELNFGAYLGLPAFLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAPEDLRDDIIENAPTTHTEEYSGEEKTWMWWHNFRTLCDYSKRIAVALEIGADLPSNHVIDRWLGEPIKAAILPTSIFLTNKKGFPVLSKMHQRLIFRLLKLEVQFIITGTNHHSEKEFCSYLQYLEYLSQNRPPPNAYELFAKGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKDTNVQVLMVLGAGRGPLVNASLRAAKQADRRIKLYAVEKNPNAVVTLENWQFEEWGSQVTVVSSDMREWVAPEKADIIVSELLGSFADNELSPECLDGAQHFLKDDGVSIPGEYTSFLAPISSSKLYNEVRACREKDRDPEAQFEMPYVVRLHNFHQLSAPQPCFTFSHPNRDPMIDNNRYCTLEFPVEVNTVLHGFAGYFETVLYQDITLSIRPETHSPGMFSWFPILFPIKQPITVREGQTICVRFWRCSNSKKVWYEWAVTAPVCSAIHNPTGRSYTIGL 6v0p A 1.88 BS02 SFG A 1 L315 Y324 F327 Y334 G365 P370 E392 K393 D419 M420 E435 L436 L299 Y308 F311 Y318 G349 P354 E376 K377 D403 M404 E419 L420 2.1.1.320 0000387,0000785,0002039,0003714,0005515,0005634,0005654,0005694,0005737,0005794,0005829,0006325,0006338,0006353,0006355,0006479,0007088,0008168,0008327,0008469,0010468,0016274,0018216,0032259,0032922,0032991,0034709,0035097,0035243,0035246,0042054,0042118,0042802,0043021,0044020,0044027,0044877,0045596,0045892,0046982,0048026,0048511,0048714,0070372,0070888,0090161,0097421,0140938,1901796,1904992 IC50=8600nM O14744 34342224 704 RVSSGRDLNCVPEIADTLGAVAKQGFDFLCMPVFHPRFKREFIQEPAKNRPGPQTRSDLLLSGRDWNTLIVGKLSPWIRPDSKVEKIRRNSEAAMLQELNFGAYLGLPAFLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAPEDLRDDIIENAPTTHTEEYSGEEKTWMWWHNFRTLCDYSKRIAVALEIGADLPSNHVIDRWLGEPIKAAILPTSIFLTNKKGFPVLSKMHQRLIFRLLKLEVQFIITGTNHEFCSYLQYLEYLSQNRPPPNAYELFAKGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKDTNVQVLMVLGAGRGPLVNASLRAAKQADRRIKLYAVEKNPNAVVTLENWQFEEWGSQVTVVSSDMREWVAPEKADIIVSELLGSFADNELSPECLDGAQHFLKDDGVSIPGEYTSFLAPISSSKLYNEVRACREKDRDPEAQFEMPYVVRLHNFHQLSAPQPCFTFSHPNRDPMIDNNRYCTLEFPVEVNTVLHGFAGYFETVLYQDITLSIRPETHSPGMFSWFPILFPIKQPITVREGQTICVRFWRCSNSKKVWYEWAVTAPVCSAIHNPTGRSYTIGL 6wkq A 1.98 BS01 SFG A 1 N6841 Y6845 G6869 G6871 P6878 G6879 D6897 L6898 D6912 C6913 D6928 M6929 Y6930 N42 Y46 G70 G72 P79 G80 D98 L99 D113 C114 D129 M130 Y131 2.1.1.56,2.1.1.57,2.7.7.48,2.7.7.50,3.1.13.-,3.4.19.12,3.4.22.-,3.4.22.69,3.6.4.12,3.6.4.13,4.6.1.- 0004483 P0DTD1 32994211 7103 SQAWQPGVAMPNLYKMQRMLLEKCDLQNYGDSATLPKGIMMNVAKYTQLCQYLNTLTLAVPYNMRVIHFGAGSDKGVAPGTAVLRQWLPTGTLLVDSDLNDFVSDADSTLIGDCATVHTANKWDLIISDMYDPKTKNVTKENDSKEGFFTYICGFIQQKLALGGSVAIKITEHSWNADLYKLMGHFAWWTAFVTNVNASSSEAFLIGCNYLGKPREQIDGYVMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLRGTAVMSLKEGQINDMILSLLSKGRLIIRENNRVVISSDVLVNN 6wkq C 1.98 BS01 SFG C 1 N6841 G6869 G6871 P6878 G6879 D6897 L6898 D6912 C6913 D6928 M6929 Y6930 F6947 N43 G71 G73 P80 G81 D99 L100 D114 C115 D130 M131 Y132 F145 2.1.1.56,2.1.1.57,2.7.7.48,2.7.7.50,3.1.13.-,3.4.19.12,3.4.22.-,3.4.22.69,3.6.4.12,3.6.4.13,4.6.1.- 0004483 P0DTD1 32994211 7103 SSQAWQPGVAMPNLYKMQRMLLEKCDLQNYGDSATLPKGIMMNVAKYTQLCQYLNTLTLAVPYNMRVIHFGAGSDKGVAPGTAVLRQWLPTGTLLVDSDLNDFVSDADSTLIGDCATVHTANKWDLIISDMYDPKTKENDSKEGFFTYICGFIQQKLALGGSVAIKITEHSWNADLYKLMGHFAWWTAFVTNVNASSSEAFLIGCNYLGKPREQIDGYVMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLRGTAVMSLKEGQINDMILSLLSKGRLIIRENNRVVISSDVLVNN 6y4g A 1.9 BS01 SFG A 1 D377 I378 D395 S511 H512 F534 R536 H538 N539 N549 Q550 D10 I11 D28 S133 H134 F156 R158 H160 N161 N171 Q172 2.1.1.348 0000398,0001510,0001734,0003723,0003729,0005515,0005634,0005654,0005737,0005794,0005829,0006397,0006974,0007283,0007623,0008168,0008173,0008757,0009048,0016556,0016604,0016607,0019827,0021861,0030154,0031053,0032259,0034644,0036396,0042063,0045087,0045580,0045727,0045746,0046982,0048477,0048511,0051445,0060339,0061157,0098508,0140640,1902036,1903679,1904047,1990204 Q86U44 32159918 601 LFPPQWICCDIRYLDVSILGKFAVVMADPPWDIGTLTDDEMRRLNIPVLQDDGFLFLWVTGRAMELGRECLNLWGYERVDEIIWVKTNQLQRIIGHWLNHGKEHCLVGVKGNPQGFNQGLDCDVIVAEVRSTSHKPDEIYGMIERLSPGTRKIELFGRPHNVQPNWITLGNQLDGIHLLDPDVVARFKQRYPDGIISK 6yz1 A 2.4 BS01 SFG A 1 N43 G71 G73 P80 D99 L100 C115 D130 M131 Y132 F149 N43 G71 G73 P80 D99 L100 C115 D130 M131 Y132 F149 2.1.1.56,2.1.1.57,2.7.7.48,2.7.7.50,3.1.13.-,3.4.19.12,3.4.22.-,3.4.22.69,3.6.4.12,3.6.4.13,4.6.1.- 0004483 P0DTD1 32709887 301 SSQAWQPGVAMPNLYKMQRMLLEKCDLQNYGDSATLPKGIMMNVAKYTQLCQYLNTLTLAVPYNMRVIHFGAGSDKGVAPGTAVLRQWLPTGTLLVDSDLNDFVSDADSTLIGDCATVHTANKWDLIISDMYDPKTKNVTKENDSKEGFFTYICGFIQQKLALGGSVAIKITEHSWNADLYKLMGHFAWWTAFVTNVNASSSEAFLIGCNYLGKPREQIDGYVMHANYIFWRNTNPIQLSSYSLFDMSKFPLKLRGTAVMSLKEGQINDMILSLLSKGRLIIRENNRVVISSDVLVN 6zxv A 1.88 BS01 SFG A 1 M156 M184 D205 F206 I210 D231 A232 D248 Y249 P250 Y251 R253 M160 M188 D209 F210 I214 D235 A236 D252 Y253 P254 Y255 R257 2.1.1.213 0000049,0003723,0005737,0008033,0008168,0016423,0016740,0030488,0032259,0160101,0160102 O29011 401 GRGSMKFLFYLSADNLEIARKEVLVLAERYGWVEDYQFEERLLLLDYAGEKFFERLAYTNEVTKIYDICSVSELEQVFSEIPVYDRLCCVRVKGGKGKTALERKLGALLWKRGAKVSVSNPEIVYKVYIQDDKCYVGLLEFERDTRQFFLRRPDRRPFLMPSAIKPKLARALVNLTGVLEGETLLDPMCGTGSFLIEAGLMGINPIGIDFIEKIVRGCRVNLEYYGIEGSVLLGDAKNLPLRDESVRGIATDYPYLRSTKAAGTLDELYSKTSEEFERVLKKGGRAAIVTNIDVESFFSNFEIEMKTEERVHGSLTRRIYLLRRH 6zxv B 1.88 BS01 SFG B 1 M184 D205 F206 I210 D231 A232 D248 Y249 P250 Y251 R253 M186 D207 F208 I212 D233 A234 D250 Y251 P252 Y253 R255 2.1.1.213 0000049,0003723,0005737,0008033,0008168,0016423,0016740,0030488,0032259,0160101,0160102 O29011 401 GSMKFLFYLSADNLEIARKEVLVLAERYGWVEDYQFEERLLLLDYAGEKFFERLAYTNEVTKIYDICSVSELEQVFSEIPVYDRLCCVRVKGGKGKTALERKLGALLWKRGAKVSVSNPEIVYKVYIQDDKCYVGLLEFERDTRQFFLRRPDRRPFLMPSAIKPKLARALVNLTGVLEGETLLDPMCGTGSFLIEAGLMGINPIGIDFIEKIVRGCRVNLEYYGIEGSVLLGDAKNLPLRDESVRGIATDYPYLRSTKAAGTLDELYSKTSEEFERVLKKGGRAAIVTNIDVESFFSNFEIEMKTEERVHGSLTRRIYLLRRH 6zxw G 2.19 BS01 SFG G 1 M184 D205 F206 I210 D231 A232 D248 Y249 P250 Y251 R253 M184 D205 F206 I210 D231 A232 D248 Y249 P250 Y251 R253 2.1.1.213 0000049,0003723,0005737,0008033,0008168,0016423,0016740,0030488,0032259,0160101,0160102 O29011 401 MKFLFYLSADNLEIARKEVLVLAERYGWVEDYQFEERLLLLDYAGEKFFERLAYTNEVTKIYDICSVSELEQVFSEIPVYDRLCCVRVKGGKGKTALERKLGALLWKRGAKVSVSNPEIVYKVYIQDDKCYVGLLEFERDTRQFFLRRPDRRPFLMPSAIKPKLARALVNLTGVLEGETLLDPMCGTGSFLIEAGLMGINPIGIDFIEKIVRGCRVNLEYYGIEGSVLLGDAKNLPLRDESVRGIATDYPYLRSTKAAGTLDELYSKTSEEFERVLKKGGRAAIVTNIDVESFFSNFEIEMKTEERVHGSLTRRIYLLRRH 7cfe A 2.02 BS01 SFG A 1 G69 S70 G71 L74 E92 P93 L94 R97 R118 E120 R137 A138 W148 G71 S72 G73 L76 E94 P95 L96 R99 R120 E122 R139 A140 W150 2.1.1.- 0005737,0005829,0005886,0006364,0008168,0008649,0031167,0032259,0070043,0070476 P9WGW9 401 HHMSPIEPAASAIFGPRLGLARRYAEALAGPGVERGLVGPREVGRLWDRHLLNCAVIGELLERGDRVVDIGSGAGLPGVPLAIARPDLQVVLLEPLLRRTEFLREMVTDLGVAVEIVRGRAEESWVQDQLGGSDAAVSRAVAALDKLTKWSMPLIRPNGRMLAIKGERAHDEVREHRRVMIASGAVDVRVVTCGANYLRPPATVVFARRGKQIA 7cv8 A 2.37 BS01 SFG A 1 D211 L212 D233 P235 P248 S362 R363 K364 F387 R389 N400 E401 D148 L149 D170 P172 P179 S285 R286 K287 F310 R312 N323 E324 2.1.1.- 0003676,0008168,0032259 Q8LFA9 501 MAKTDKLAQFLDSGIYESDEFNWFFLDTVRITNRSYTRFKVSPSAYYSRFFNNLRHQEARLFLSKAHESFLKEIELLSLTKGLDEVSFIELGGVWQAPFYEITLSFNEQRVFQVFNNLVVNEIGEEVEAEFSNRRYIMPRNSCFYMSDLHHIRNLVPAKSEEGYNLIVIDPPWENSKYPTLPNQYFLSLPIKQLAHAEGALVALWVTNREKLLSFVEKELFPAWGIKYVATMYWLKVKPDGTLICDLDLVHHKPYEYLLLGYHFRSDFKLLDKNQIIMSIPGDFSRKPPIGDILLKHTPGSQPARCLELFAREMAAGWTSWGNEPLHFQDSRYFLKV 7dsu A 3.2 BS01 SFG A 1 E97 N98 D123 K401 Y424 G426 S427 T429 N452 I457 E80 N81 D106 K261 Y284 G286 S287 T289 N312 I317 ? 0003676,0003677,0008168,0008170,0032259 A0A2N8U1P8 601 IKQDYIEKANALSLSNELNQDQKDLILSIYQLMIKRVKLGFVFDIAPSVNASEIALFKKDEKLSFNNDNNKPTNTLIIGENYDALKNLIVIESQSETVNYDVIYIDPPYNYRGKFSRTGWLNMLNERLRMAKQLLKEDGVIFVSIDDSEQAYLKVLMDEIFGEENFIACVPAILNPSGRQVNTEIALTHEYILIYGGVNFVPEELDNEYVINKLPEIYKNPKKRKNTWIFKTIIKGSSFNNKTGNKVLSSILKSDEFSTAKPVELIKLLIKLHPNNNARILDFYAGSGTTGHAVMELNKEDGGNRCYTLVTNNENNIATNVCYERLYRINNGIYTNNESNFDWIKKNKPYKSNLNVYDIEYFSTKLFDDNQSNMSIKEQYIKMLQDFNIDTEDKDSNIDILRSLTSLKPISK 7dsu B 3.2 BS01 SFG B 1 E97 N98 D123 N136 Y424 G426 S427 T429 N452 I457 E81 N82 D107 N120 Y300 G302 S303 T305 N328 I333 ? 0003676,0003677,0008168,0008170,0032259 A0A2N8U1P8 601 ANALSLSNELNQDQKDLILSIIDKFALHNVYQLMIKRVKLGFVFDIAPSVNASEIALFKKDEKLSFNNDNNKPTNTLIIGENYDALKNLIVIESQSETVNYDVIYIDPPYNTESSLSDGNNLSSKFIYRGKFSRTGWLNMLNERLRMAKQLLKEDGVIFVSIDDSEQAYLKVLMDEIFGEENFIACVPAILNPSGRQVNTEIALTHEYILIYGGVNFVPEELDNEYVINKLPEIYKNKKRKNTWIFKTIIKGSSFNNKTGNKVLSSILKSDEFSTAKPVELIKLLIKLHPNNNARILDFYAGSGTTGHAVMELNKEDGGNRCYTLVTNNENNIATNVCYERLYRINNGIYTNNESNFDWIKKNKPYKSNLNVYDIEYFSTKLFDNMSIKEQYIKMLQDFNIDTEDKDSNIDILRSLTSLK 7e8d K 2.8 BS05 SFG K 1 K1073 W1075 T1115 H1116 F1117 Y1118 F1139 N1141 H1142 Y1179 K88 W90 T130 H131 F132 Y133 F154 N156 H157 Y194 2.1.1.357 0005634,0042054 O96028 34782608 1304 RKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKPTDENPCGFDSECLNRMLMFECHPQVCPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDKEECMARIKHAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLG 7f8c A 2.248 BS01 SFG A 1 Q13 N14 F15 L16 G40 A41 G42 A45 E61 V62 D92 F93 N108 P110 Q1 N2 F3 L4 G28 A29 G30 A33 E49 V50 D79 F80 N95 P97 ? 0000154,0000179 Q79N53 35007529 301 QNFLSDRRVIADIVEIVSRTNGPIIEIGAGDGALTIPLQRLARPLTAVEVDARRARRLAQRTARSAPGPASPTEVVAADFLRYPLPRSPHVVVGNLPFHLTTAILRRLLHGPGWTTAVLLMQWEVARRRAAVGGATMMTAQWWPWFEFGLARKVSAASFTPRPAVDAGLLTITRRSRPLVDVADRARYQALVHRVFTGRGHGMAQILQRLPVPRTWLRANGIAPNSLPRQLSAAQWAALFEQT 7nh7 A 2.2 BS01 SFG A 1 N43 G71 G73 P80 D99 L100 C115 D130 M131 N43 G71 G73 P80 D99 L100 C115 D130 M131 2.1.1.56,2.1.1.57,2.7.7.48,2.7.7.50,3.1.13.-,3.4.19.12,3.4.22.-,3.6.4.12,3.6.4.13,4.6.1.- 0004483 P0C6X6 301 AASDWKPGYSMPVLYKYLNSPMERVSLWNYGKPVTLPTGCMMNVAKYTQLCQYLNTTTLAVPVNMRVLHLGAGSEKGVAPGSAVLRQWLPAGTILVDNDLYPFVSDSVATYFGDCITLPFDCQWDLIISDMYDPITKNIGEYNVSKDGFFTYICHMIRDKLALGGSVAIKITEFSWNAELYKLMGYFAFWTVFCTNANASSSEGFLIGINYLCKPKVEIDGNVMHANYLFWRNSTVWNGGAYSLFDMAKFPLKLAGTAVINLRADQINDMVYSLLEKGKLLIRDTNKEVFVGDSL 7pl1 A 1.85 BS01 SFG A 1 G54 C55 G56 E77 I78 R79 S109 N110 A111 L130 F131 T208 E210 G36 C37 G38 E59 I60 R61 S91 N92 A93 L112 F113 T184 E186 2.1.1.-,2.1.1.33 0006400,0008176 Q9UBP6 307 LRYPVKPEEMDWSELYPEFFAPLKRAQAQVEFADIGCGYGGLLVELSPLFPDTLILGLEIRVKVSDYVQDRIRALRAAPAGGFQNIACLRSNAMKHLPNFFYKGQLTKMFFLFPDPHFWRIISPTLLAEYAYVLRVGGLVYTITDVLELHDWMCTHFEEHPLFERVPLEDLSEDPVVGHLGTSTEEGKKVLRNGGKNFPAIFRRIQDPVL 7rfk A 2.05 BS03 SFG A 1 S27 G28 Y30 Y31 T32 D60 S62 N67 F68 D114 I115 D149 S150 N165 P167 S22 G23 Y25 Y26 T27 D55 S57 N62 F63 D109 I110 D140 S141 N156 P158 2.1.1.72 0003676,0006304,0008168,0009007,0032259 Q183J3 34523387 601 QDNFLLSKEYENSLDVDTKKASGIYYTPKIIVDYIVKKTLKNHDIIKNPYPRILDISCGCGNFLLEVYDILYDLFEENIYELKKKYDENYWTVDNIHRHILNYCIYGADIDEKAISILKDSLTNKKVVESDIKINLFCCDSLKKKWRYKFDYIVGNPPYIGHKKLEKKYKKFLLEKYSEVYKDKADLYFCFYKKIIDILKQGGIGSVITPRYFLESLSGKDLREYIKSNVNVQEIVDFLGANIFKNIGVSSCILTFDKKKTKETYIDVFKIKNEDICINKFETLEELLKSSKFEHFNINQRLLSDEWILVNKDDETFYNKIQEKCKYSLEDIAISFQGIITGCDKAFILSKDDVKLNLVDDKFLKCWIKSKNINKYIVDKSEYRLIYSNDIDNENTNKRILDEIIGLYKTKLENRRECKSGIRKWYELQWGREKLFFERKKIMYPYKSNENRFAIDYDNNFSSADVYSFFIKEEYLDKFSYEYLVGILNSSVYDKYFKITAKKMSKNIYDYYPNKVMKIRIFRDNNYEEIENLSKQIISILLNKSIDKGKVEKLQIKMDNLIMDSLGI 7rfk B 2.05 BS03 SFG B 1 S27 G28 Y30 Y31 T32 S62 C63 G64 F68 D114 I115 D149 S150 N165 P167 S25 G26 Y28 Y29 T30 S60 C61 G62 F66 D112 I113 D147 S148 N163 P165 2.1.1.72 0003676,0006304,0008168,0009007,0032259 Q183J3 34523387 601 DISQDNFLLSKEYENSLDVDTKKASGIYYTPKIIVDYIVKKTLKNHDIIKNPYPRILDISCGCGNFLLEVYDILYDLFEENIYELKKKYDENYWTVDNIHRHILNYCIYGADIDEKAISILKDSLTNKKVVNDLDESDIKINLFCCDSLKKKWRYKFDYIVGNPPYIGHKKLEKKYKKFLLEKYSEVYKDKADLYFCFYKKIIDILKQGGIGSVITPRYFLESLSGKDLREYIKSNVNVQEIVDFLGANIFKNIGVSSCILTFDKKKTKETYIDVFKIKNEDICINKFETLEELLKSSKFEHFNINQRLLSDEWILVNKDDETFYNKIQEKCKYSLEDIAISFQGIITGCDKAFILSKDDVKLNLVDDKFLKCWIKSKNINKYIVDKSEYRLIYSNDIDNENTNKRILDEIIGLYKTKLENRRECKSGIRKWYELQWGREKLFFERKKIMYPYKSNENRFAIDYDNNFSSADVYSFFIKEEYLDKFSYEYLVGILNSSVYDKYFKITAKKMSKNIYDYYPNKVMKIRIFRDNNYEEIENLSKQIISILLNKSIDKGKVEKLQIKMDNLIMDSLGI 7rfk C 2.05 BS03 SFG C 1 S27 G28 Y30 Y31 T32 S62 C63 F68 D114 I115 D149 S150 N165 F200 S22 G23 Y25 Y26 T27 S57 C58 F63 D109 I110 D134 S135 N150 F185 2.1.1.72 0003676,0006304,0008168,0009007,0032259 Q183J3 34523387 601 QDNFLLSKEYENSLDVDTKKASGIYYTPKIIVDYIVKKTLKNHDIIKNPYPRILDISCGCGNFLLEVYDILYDLFEENIYELKKKYDENYWTVDNIHRHILNYCIYGADIDEKAISILKDSLTNDIKINLFCCDSLKKKWRYKFDYIVGNPPYIGHKKLEKKYKKFLLEKYSEVYKDKADLYFCFYKKIIDILKQGGIGSVITPRYFLESLSGKDLREYIKSNVNVQEIVDFLGANIFKNIGVSSCILTFDKKKTKETYIDVFKIKNEDICINKFETLEELLKSSKFEHFNINQRLLSDEWILVNKDDETFYNKIQEKCKYSLEDIAISFQGIITGCDKAFILSKDDVKLNLVDDKFLKCWIKSKNINKYIVDKSEYRLIYSNDIDNENTNKRILDEIIGLYKTKLENRRECKSGIRKWYELQWGREKLFFERKKIMYPYKSNENRFAIDYDNNFSSADVYSFFIKEEYLDKFSYEYLVGILNSSVYDKYFKITAKKMSKNIYDYYPNKVMKIRIFRDNNYEEIENLSKQIISILLNKSIDKGKVEKLQIKMDNLIMDSLGI 7s1p A 2.21 BS01 SFG A 1 L315 Y324 Y334 G365 P370 E392 K393 D419 M420 E435 L436 L294 Y303 Y313 G344 P349 E371 K372 D398 M399 E414 L415 2.1.1.320 0000387,0000785,0002039,0003714,0005515,0005634,0005654,0005694,0005737,0005794,0005829,0006325,0006338,0006353,0006355,0006479,0007088,0008168,0008327,0008469,0010468,0016274,0018216,0032259,0032922,0032991,0034709,0035097,0035243,0035246,0042054,0042118,0042802,0043021,0044020,0044027,0044877,0045596,0045892,0046982,0048026,0048511,0048714,0070372,0070888,0090161,0097421,0140938,1901796,1904992 O14744 35041419 701 RVSSGRDLNCVPEIADTLGAVAKQGFDFLCMPVFHPRFKREFIQEPAKNRPGPQTRSDLLLSGRDWNTLIVGKLSPWIRPDSKVEKIRRNSEAAMLQELNFGAYLGLPAFLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAPEDLRDDIIENAPTTHTEEYSGEEKTWMWWHNFRTLCDYSKRIAVALEIGADLPSNHVIDRWLGEPIKAAILPTSIFLTNKKGFPVLSKMHQRLIFRLLKLEVQFIITGTNHHFCSYLQYLEYLSQNRYELFAKGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKDTNVQVLMVLGAGRGPLVNASLRAAKQADRRIKLYAVEKNPNAVVTLENWQFEEWGSQVTVVSSDMREWVAPEKADIIVSELLGSFADNELSPECLDGAQHFLKDDGVSIPGEYTSFLAPISSSKLYNEVRACREKDRDPEAQFEMPYVVRLHNFHQLSAPQPCFTFSHPNRDPMIDNNRYCTLEFPVEVNTVLHGFAGYFETVLYQDITLSIRPETHSPGMFSWFPILFPIKQPITVREGQTICVRFWRCSNSKKVWYEWAVTAPVCSAIHNPTGRSYTIGL 7tw9 A 1.41 BS01 SFG A 1 R310 G333 P335 D352 A353 F367 Y368 W385 N386 C387 R88 G111 P113 D130 A131 F145 Y146 W163 N164 C165 2.1.1.56,2.1.1.57,2.7.7.48,2.7.7.50,3.1.13.-,3.4.19.12,3.4.22.-,3.4.22.69,3.6.4.12,3.6.4.13,4.6.1.- 0004482,0004532,0008168,0043565 P0DTD1,P41212 36075969 601 LPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMNGKALLLLTKEDFRYRSPHSGDELYELLQHILAQPAAGDELKINAACRKVQHMVVKAALLADKFPVLHDIGNPKAIKCVPQADVEWKFYDAQPCSDKAYKIEELFYSYATHSDKFTDGVCLFWNCNVDRYPANSIVCRFDKSAFVNLKQLPFFYYSDSPCESHVPLKSATCITRCNLGGAVCRHHANEYRLYLDAYNMMISAGFSLWVYKQFDTYNLWNTF 7v1c A 1.95 BS01 SFG A 1 S56 G81 G86 W87 T104 I105 M130 D131 V132 F133 D146 S51 G76 G81 W82 T99 I100 M125 D126 V127 F128 D141 3.4.21.91,3.6.1.15,3.6.4.13 0004482,0004483,0008168,0032259 C4TPE0 35758665 404 MTLGDLWKRRLNNCTKEEFFAYRRTGILETERDKARELLRKGETNMGLAVSRGTAKLAWLEERGYVNLKGEVVDLGCGRGGWSYYAASRPAVMGVKAYTIGGKGHEAPKMVTSLGWNLIKFRAGMDVFTMQPHRADTVMCDIGESSPDAAIEGERTRKVILLMEQWKNRNPSASCVFKVLAPYRPEVIEALHRFQLQWGGGLVRTPFSRNSTHEMYYSTAISGNIVNSVNVQSRKLLARFGDQRGPIRVPEMDLGVGTRH 7x73 A 1.49 BS05 SFG A 1 M1048 W1050 S1084 Y1085 R1109 F1110 N1112 H1113 Y1154 F1166 C1168 Q1169 M132 W134 S168 Y169 R193 F194 N196 H197 Y238 F250 C252 Q253 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q96KQ7 36635268 1205 RTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLA 7x73 B 1.49 BS05 SFG B 1 M1048 W1050 S1084 Y1085 R1109 F1110 N1112 H1113 Y1154 C1168 Q1169 M130 W132 S166 Y167 R191 F192 N194 H195 Y236 C250 Q251 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q96KQ7 36635268 1205 IRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLAR 7xua A 1.87 BS05 SFG A 1 M1048 G1049 W1050 S1084 Y1085 R1109 N1112 H1113 W1159 F1166 C1168 M133 G134 W135 S169 Y170 R194 N197 H198 W244 F251 C253 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q96KQ7 36882960 1205 IRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSR 7xua B 1.87 BS05 SFG B 1 M1048 W1050 S1084 Y1085 R1109 F1110 N1112 H1113 Y1154 F1166 C1168 Q1169 M132 W134 S168 Y169 R191 F192 N194 H195 Y236 F248 C250 Q251 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q96KQ7 36882960 1205 RTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRLARL 7xub A 2.0 BS05 SFG A 1 M1048 W1050 S1084 Y1085 R1109 F1110 N1112 H1113 Y1154 W1159 C1168 Q1169 M133 W135 S169 Y170 R194 F195 N197 H198 Y239 W244 C253 Q254 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q96KQ7 36882960 1205 IRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALE 7xub B 2.0 BS05 SFG B 1 M1048 W1050 S1084 Y1085 R1109 F1110 N1112 H1113 Y1154 C1168 M132 W134 S168 Y169 R190 F191 N193 H194 Y235 C249 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q96KQ7 36882960 1205 RTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALE 7xuc A 1.67 BS05 SFG A 1 M1048 W1050 S1084 Y1085 R1109 F1110 N1112 H1113 Y1154 F1166 C1168 M131 W133 S167 Y168 R192 F193 N195 H196 Y237 F249 C251 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q96KQ7 36882960 1205 IRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRL 7xuc B 1.67 BS05 SFG B 1 M1048 W1050 S1084 Y1085 R1109 F1110 N1112 H1113 Y1154 F1166 C1168 Q1169 M128 W130 S164 Y165 R189 F190 N192 H193 Y234 F246 C248 Q249 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q96KQ7 36882960 1205 RTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRL 7xud A 1.45 BS05 SFG A 1 M1048 W1050 S1084 Y1085 R1109 F1110 N1112 H1113 Y1154 F1166 C1168 M128 W130 S164 Y165 R189 F190 N192 H193 Y234 F246 C248 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q96KQ7 36882960 1206 IRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSR 7xud B 1.45 BS05 SFG B 1 M1048 W1050 S1084 Y1085 R1109 F1110 N1112 H1113 Y1154 F1166 C1168 Q1169 M129 W131 S165 Y166 R190 F191 N193 H194 Y235 F247 C249 Q250 2.1.1.-,2.1.1.367 0002039,0005634,0008270,0016279,0042054 Q96KQ7 36882960 1205 RTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFEPPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQSRL 7yrj A 2.35 BS01 SFG A 1 R73 G132 D150 L151 A161 D162 S196 L197 L198 M202 R4 G63 D81 L82 A92 D93 S127 L128 L129 M133 2.1.1.- Q9W138 401 ARSRIKWAIDYITKYFFTEGIYLQKRQREQRLLESYRAEGKLGEVQCRLMEEPPDRLHVLDVGSCFNPFSSAPHLEVTALDLCPATEDVLQADFLKVEVVPGIREPELEEGSVRRLPASHYECVIFSLLLEYMPSAEQRLQCCLQAYDLLLPEGILVLITPDAHLMKNWRYSLARIGLLRVRFEKLPHISCMVFRKAISRELSQHWASIHREE 7yrj B 2.35 BS01 SFG B 1 R73 G132 D150 L151 D162 F163 S196 L197 L198 M202 R4 G63 D81 L82 D93 F94 S127 L128 L129 M133 2.1.1.- Q9W138 401 ARSRIKWAIDYITKYFFTEGIYLQKRQREQRLLESYRAEGKLGEVQCRLMEEPPDRLHVLDVGSCFNPFSSAPHLEVTALDLCPATEDVLQADFLKVEVVPGIREPELEEGSVRRLPASHYECVIFSLLLEYMPSAEQRLQCCLQAYDLLLPEGILVLITPDAHLMKNWRYSLARIGLLRVRFEKLPHISCMVFRKAISRELSQHWASIHREE 7yrj C 2.35 BS01 SFG C 1 R73 G132 D150 L151 A161 S196 L197 L198 Y201 M202 R2 G61 D79 L80 A90 S125 L126 L127 Y130 M131 2.1.1.- Q9W138 401 SRIKWAIDYITKYFFTEGIYLQKRQREQRLLESYRAEGKLGEVQCRLMEEPPDRLHVLDVGSCFNPFSSAPHLEVTALDLCPATEDVLQADFLKVEVVPGIREPELEEGSVRRLPASHYECVIFSLLLEYMPSAEQRLQCCLQAYDLLLPEGILVLITPDMKNWRYSLARIGLLRVRFEKLPHISCMVFRKAISRELSQHWASIH 7yrj D 2.35 BS01 SFG D 1 R73 G132 D150 L151 D162 S196 L197 L198 Y201 M202 R2 G61 D79 L80 D91 S125 L126 L127 Y130 M131 2.1.1.- Q9W138 401 SRIKWAIDYITKYFFTEGIYLQKRQREQRLLESYRAEGKLGEVQCRLMEEPPDRLHVLDVGSCFNPFSSAPHLEVTALDLCPATEDVLQADFLKVEVVPGIREPELEEGSVRRLPASHYECVIFSLLLEYMPSAEQRLQCCLQAYDLLLPEGILVLITPDMKNWRYSLARIGLLRVRFEKLPHISCMVFRKAISRELSQHWASI 8b07 A 2.05 BS01 SFG A 1 Q39 L42 G68 A70 P71 G72 H74 D95 R97 F115 V116 D138 R140 Q30 L33 G59 A61 P62 G63 H65 D86 R88 F106 V107 D129 R131 2.1.1.57 0003746,0004483,0006370,0006412,0006414,0008168,0031440,0032259,0044423 A0A7H0DN74 37080993 401 MDVVSLDKPFMYFEEIDNELDYEKLPYQGQLKLLLGELFFLSKLQRHGILDGATVVYIGSAPGTHIRYLRDHFYNLGVIIKWMLIDGRHHDPILNGLRDVTLVTRFVDEEYLRSIKKQLHPSKIILISDVRSEPSTADLLSNYALQNVMISILNPVASSLKWRCPFPDQWIKDFYIPHGNKMLQPFAPSYSAEMRLLSIYTGENMRLTRVTKSDAVNYEKKMYYLNKIVRNKVVINFDYPNQEYDYFHMYFMLRTVYCNKTFPTTKAKILFLQQSIFRFLNIP 8b07 B 2.05 BS01 SFG B 1 Q39 L42 G68 S69 A70 P71 G72 H74 D95 R97 V116 D138 V139 R140 Q30 L33 G59 S60 A61 P62 G63 H65 D86 R88 V107 D129 V130 R131 2.1.1.57 0003746,0004483,0006370,0006412,0006414,0008168,0031440,0032259,0044423 A0A7H0DN74 37080993 401 DVVSLDKPFMYFEEIDNELDYEPKLPYQGQLKLLLGELFFLSKLQRHGILDGATVVYIGSAPGTHIRYLRDHFYNLGVIIKWMLIDGRHHDPILNGLRDVTLVTRFVDEEYLRSIKKQLHPSKIILISDVRSKEPSTADLLSNYALQNVMISILNPVASSLKWRCPFPDQWIKDFYIPHGNKMLQPFAPSYSAEMRLLSIYTGENMRLTRVTKSDAVNYEKKMYYLNKIVRNKVVINFDYPNQEYDYFHMYFMLRTVYCNKTFPTTKAKILFLQQSIFRFLNIP 8b51 A 1.84 BS01 SFG A 1 S57 G59 G82 G87 W88 T105 K106 H111 E112 V131 D132 V133 Y134 D147 I148 S51 G53 G76 G81 W82 T99 K100 H105 E106 V125 D126 V127 Y128 D141 I142 2.1.1.56,2.1.1.57,2.7.7.48,3.4.21.91,3.6.1.15,3.6.4.13 0004482,0004483,0008168,0032259 Q5WPU5 36334638 301 RTLGEQWKEKLNGLSKEDFLKYRKEAITEVDRSAARKARRDGNKTGGHPVSRGSAKLRWMVERQFVKPIGKVVDLGCGRGGWSYYAATLKGVQEVRGYTKGGPGHEEPMLMQSYGWNLVTMKSGVDVYYKPSEPCDTLFCDIGESSSSAEVEEQRTLRILEMVSDWLQRGPREFCIKVLCPYMPRVMERLEVLQRRYGGGLVRVPLSRNSNHEMYWVSGAAGNIVHAVNMTSQVLIGRMEKRTWHGPKYEEDVNLGSGTRA 8b51 B 1.84 BS01 SFG B 1 S57 G82 G87 W88 K106 H111 E112 V131 D132 V133 Y134 D147 I148 S51 G76 G81 W82 K100 H105 E106 V125 D126 V127 Y128 D141 I142 2.1.1.56,2.1.1.57,2.7.7.48,3.4.21.91,3.6.1.15,3.6.4.13 0004482,0004483,0008168,0032259 Q5WPU5 36334638 301 RTLGEQWKEKLNGLSKEDFLKYRKEAITEVDRSAARKARRDGNKTGGHPVSRGSAKLRWMVERQFVKPIGKVVDLGCGRGGWSYYAATLKGVQEVRGYTKGGPGHEEPMLMQSYGWNLVTMKSGVDVYYKPSEPCDTLFCDIGESSSSAEVEEQRTLRILEMVSDWLQRGPREFCIKVLCPYMPRVMERLEVLQRRYGGGLVRVPLSRNSNHEMYWVSGAAGNIVHAVNMTSQVLIGRMEKTWHGPKYEEDVNLGSGTRA 8bxk A 2.31 BS01 SFG A 1 S57 G59 G82 G87 W88 T105 K106 H111 E112 V131 D132 V133 F134 D147 I148 S56 G58 G81 G86 W87 T104 K105 H110 E111 V130 D131 V132 F133 D146 I147 3.4.21.91,3.6.1.15,3.6.4.13 0004482,0004483,0008168,0032259 K0BRZ6 301 GGGRGRMLGEMWKAQLNQLTRQEFMEYRRDGIIEVDRSAARKARREGNVTGGHPVSRGTAKLRWMVERGFVKPHGKVIDLGCGRGGWSYYCATLKLVQEVKGYTKGGPGHEEPVMMQSYGWNLVSLKSGVDVFYRPSEQSDTLLCDIGEASPVPEIEEARTVKVLQMVEEWLSRGVEDFCVKILCPYMPKVLKELEKMQLRWGGGLIRVPLSRNSNHEMYWVSGASGNITNSVNTVSQMLINRMNRTNRNGPKYEEDVHLGSGTR 8bxk B 2.31 BS01 SFG B 1 S57 G59 G82 G87 W88 T105 K106 H111 E112 V131 D132 V133 F134 D147 I148 S52 G54 G77 G82 W83 T100 K101 H106 E107 V126 D127 V128 F129 D142 I143 3.4.21.91,3.6.1.15,3.6.4.13 0004482,0004483,0008168,0032259 K0BRZ6 301 GRMLGEMWKAQLNQLTRQEFMEYRRDGIIEVDRSAARKARREGNVTGGHPVSRGTAKLRWMVERGFVKPHGKVIDLGCGRGGWSYYCATLKLVQEVKGYTKGGPGHEEPVMMQSYGWNLVSLKSGVDVFYRPSEQSDTLLCDIGEASPVPEIEEARTVKVLQMVEEWLSRGVEDFCVKILCPYMPKVLKELEKMQLRWGGGLIRVPLSRNSNHEMYWVSGASGNITNSVNTVSQMLINRMNRTNRNGPKYEEDVHLGSGTR 8gya A 2.005 BS01 SFG A 1 S99 C124 G129 W130 L148 E154 N168 V169 D183 S53 C78 G83 W84 L102 E105 N119 V120 D134 3.6.4.13 0008168,0032259 A0A344X2I6 37831643 1001 PLGSEVYKGDGYKVWKLEPSLGDPLELGRKTKTEMNAMTHDEFDRMKYGDKPSKGYDKLRVLLDLMDRPRLGTTVDLCAGRGGWSELVKDLEGPKGITAVSLWEEEWMADPAIHRINANVKHLRPWQVDTLLFDGGEAFKRDQNLRKEENFNDSLLDAVDAWMMQPVPPRNFVIKIQVPYTQKAIALLEKWQVKTGKGRLVRLAGDRLSNTVMYFLSVRLETQIRGRVTTFVRELAERRKDRSLT 8gya B 2.005 BS01 SFG B 1 S99 C124 G129 W130 S147 N168 V169 D183 S53 C78 G83 W84 S101 N119 V120 D134 3.6.4.13 0008168,0032259 A0A344X2I6 37831643 1001 PLGSEVYKGDGYKVWKLEPSLGDPLELGRKTKTEMNAMTHDEFDRMKYGDKPSKGYDKLRVLLDLMDRPRLGTTVDLCAGRGGWSELVKDLEGPKGITAVSLWEEEWMADPAIHRINANVKHLRPWQVDTLLFDGGEAFKRDQNLRKEENFNDSLLDAVDAWMMQPVPPRNFVIKIQVPYTQKAIALLEKWQVKTGKGRLVRLAGDRLSNTVMYFLSVRLETQIRGRVTTFVRELAERRKDRSLTAD 8ipm D 3.1 BS03 SFG D 1 T27 F28 G29 G32 H33 D50 R51 F77 D100 S104 E226 T21 F22 G23 G26 H27 D44 R45 F71 D94 S98 E220 2.1.1.- 0008168 A6NJ78 38291322 401 MVDEVVHCLSPQKGQIFLDMTFGSGGHTKAILQKESDIVLYALDRDPTAYALAEHLSELYPKQIRAMLGQFSQAEALLMKAGVQPGTFDGVLMDLGCSSMQLDTPERGFSLRKDGPLDMRMDGGRYPDMPTAADVVNALDQQALASILRTYGEEKHAKKIASAIVQARSIYPITRTQQLASIVAGAFPPSAIYTRKDLLQRSTHIATKTFQALRIFVNNELNELYTGLKTAQKFLRPGGRLVALSFHSLEDRIVKRFLLGISMLMWELIHKKVAKLRAAIKL 8joz A 2.22 BS02 SFG A 1 D3 R4 F6 F13 Y18 R26 G52 G53 D73 L74 M78 A101 A102 Q103 H119 A120 D3 R4 F6 F13 Y18 R26 G52 G53 D73 L74 M78 A101 A102 Q103 H119 A120 2.1.1.- 0002098,0006400,0008033,0008168,0030488,0032259,0097697 P36566 37587716 301 AQDRNFDDIAEKFSRNIYGTTKGQLRQAILWQDLDRVLAEMGPQKLRVLDAGGGEGQTAIKMAERGHQVILCDLSAQMIDRAKQAAEAKGVSDNMQFIHCAAQDVASHLETPVDLILFHAVLEWVADPRSVLQTLWSVLRPGGVLSLMFYNAHGLLMHNMVAGNFDYVQAGMPKKKKRTLSPDYPRDPAQVYLWLEEAGWQIMGKTGVRVFHDYLREKHQQRDCYEALLELETRYCRQEPYITLGRYIHVTARKPQS 8pb5 A 0.89 BS01 SFG A 1 L68 R75 G107 T108 E131 V132 T158 N183 I215 E216 F226 L79 R86 G118 T119 E142 V143 T169 N194 I226 E227 F237 2.1.1.- 0005634,0008168,0032259,0052907,0070475,0140380,0140381 P0DPA9 38548735 401 HMASENLYFQGMHIRNPYRTPIDYQALSEAFPPLKPFVSVNADGTSSVDLTIPEAQRAFTAALLHRDFGLTMTIPEDRLCPTVPNRLNYVLWIEDIFNYTNKTLGLSDDRPIKGVDIGTGASAIYPMLACARFKAWSMVGTEVERKCIDTARLNVVANNLQDRLSILETSIDGPILVPIFEATEEYEYEFTMCNPPFYDGAADMQTSDAAKGFGFGVGAPHSGTVIEMSTEGGESAFVAQMVRESLKLRTRCRWYTSNLGKLKSLKEIVGLLKELEISNYAINEYVQGSTRRYAVAWSFTDIQLPEELSRPSNPELSSLF 8pb7 A 0.92 BS01 SFG A 1 L68 R75 G107 T108 E131 V132 T158 N183 E216 F226 L79 R86 G118 T119 E142 V143 T169 N194 E227 F237 2.1.1.- 0005634,0008168,0032259,0052907,0070475,0140380,0140381 P0DPA9 38548735 401 HMASENLYFQGMHIRNPYRTPIDYQALSEAFPPLKPFVSVNADGTSSVDLTIPEAQRAFTAALLHRDFGLTMTIPEDRLCPTVPNRLNYVLWIEDIFNYTNKTLGLSDDRPIKGVDIGTGASAIYPMLACARFKAWSMVGTEVERKCIDTARLNVVANNLQDRLSILETSIDGPILVPIFEATEEYEYEFTMCNPPFYDGAADMQTSDAAKGFGFGVGAPHSGTVIEMSTEGGESAFVAQMVRESLKLRTRCRWYTSNLGKLKSLKEIVGLLKELEISNYAINEYVQGSTRRYAVAWSFTDIQLPEELSRPSNPELSSLF 8q9w A 2.5 BS01 SFG A 1 K180 G205 D227 I228 Q284 F285 Y289 M300 K11 G36 D58 I59 Q115 F116 Y120 M131 O43148 501 FYLRNFNNWMKSVLIGEFLEKVRQKKKRDITVLDLGCGKGGDLLKWKKGRINKLVCTDIADVSVKQCQQRYEDMKNRRDSEYIFSAEFITADSSKELLIDKFRDPQMCFDICSCQFVCHYSFESYEQADMMLRNACERLSPGGYFIGTTPNSFELIRRLEASETESFGNEIYTVKFQKKGDYPLFGCKYDFNLEGVVDVPEFLVYFPLLNEMAKKYNMKLVYKKTFLEFYEEKIKNNENKMLLKRMGLGCLSKSEWEATSIYLVFAFEKQQ 8q9w B 2.5 BS01 SFG B 1 G205 C206 D227 I228 D261 G39 C40 D61 I62 D95 O43148 501 SRIFYLRNFNNWMKSVLIGEFLEKVRQKKKRDITVLDLGCGKGGDLLKWKKGRINKLVCTDIADVSVKQCQQRYEDMKNRRDSEYIFSAEFITADSSKELLIDKFRDPQMCFDICSCQFVCHYSFESYEQADMMLRNACERLSPGGYFIGTTPNSFELIRRLEASETESFGNEIYTVKFQKKGDYPLFGCKYDFNLEGVVDVPEFLVYFPLLNEMAKKYNMKLVYKKTFLEFYEEKIKNNENKMLLKRMGLGCLSKSEWEATSIYLVFAFEKQQ 8qdj A 1.8 BS01 SFG A 1 S57 G59 G82 G87 W88 T105 K106 H111 E112 V131 D132 V133 F134 D147 I148 S52 G54 G77 G82 W83 T100 K101 H106 E107 V126 D127 V128 F129 D142 I143 K0BRZ6 38781970 301 GRMLGEMWKAQLNQLTRQEFMEYRRDGIIEVDRSAARKARREGNVTGGHPVSRGTAKLRWMVERGFVKPHGKVIDLGCGRGGWSYYCATLKLVQEVKGYTKGGPGHEEPVMMQSYGWNLVSLKSGVDVFYRPSEQSDTLLCDIGEASPVPEIEEARTVKVLQMVEEWLSRGVEDFCVKILCPYMPKVLKELEKMQLRWGGGLIRVPLSRNSNHEMYWVSGASGNITNSVNTVSQMLINRMNRTNRNGPKYEEDVHLGSGTR 8s9m A 1.49 BS01 SFG A 1 D88 S89 S107 P109 Y127 H253 A255 P256 F257 F280 S283 T285 D301 I302 Y306 D10 S11 S29 P31 Y49 H170 A172 P173 F174 F197 S200 T202 D218 I219 Y223 0003677,0008170,0009307,0015667 37414145 401 SFTNKYVVLDSLEGLRSLPDNSVQCVVTSPPYNKLGLREGRPYLGQIIYDTYDDNMNEDDYQKWQLQILNEINRILKPGGSAFYNHKDRRFCKRDHPPEKFLSDSDLELYQTIIWDRGSTVNQNARYFRPYVEKIFWFTKSITPKFHRDRLPEYFKGVIWRIPPDKRNKHPAPFPAILAEICILTTTEEGDLVLDPFAGSGTTLVAAASLKRSYLGFDISSKYQKMFHQRLATSKSKVHLW 8s9n A 1.89 BS01 SFG A 1 S89 S107 P109 H253 A255 P256 F257 F280 A281 S283 T285 D301 I302 Y306 S22 S40 P42 H153 A155 P156 F157 F180 A181 S183 T185 D201 I202 Y206 0003677,0008170,0009307,0015667 37414145 401 NSDSFQKKKLKSFTNKYVVLDSLEGLRSLPDNSVQCVVTSPPYNEDDYQKWQLQILNEINRILKPGGSAFYNHKPPEKFLSDSDLELYQTIIWDRGSTVNQNARYFRPYVEKIFWFTKSISGESTTPKFHRDRLPEYFKGVIWRIPPDKRNKHPAPFPAILAEICILTTTEEGDLVLDPFAGSGTTLVAAASLKRSYLGFDISSKYQKMFHQRLATSKSKVHLW 8s9o A 1.94 BS01 SFG A 1 S89 S107 P109 L113 K165 H253 A255 P256 F257 F280 A281 G282 S283 T285 D301 I302 Y306 S23 S41 P43 L47 K78 H159 A161 P162 F163 F186 A187 G188 S189 T191 D207 I208 Y212 0003677,0008170,0009307,0015667 37414145 401 SNSDSFQKKKLKSFTNKYVVLDSLEGLRSLPDNSVQCVVTSPPYNKLNEDDYQKWQLQILNEINRILKPGGSAFYNHKDHPPEKFLSDSDLELYQTIIWDRGSTVNQNARYFRPYVEKIFWFTKSISGESTTPKFHRDRLPEYFKGVIWRIPPDKRNKHPAPFPAILAEICILTTTEEGDLVLDPFAGSGTTLVAAASLKRSYLGFDISSKYQKMFHQRLATSKSKVHLW 8s9o B 1.94 BS01 SFG B 1 S89 S107 P109 K112 H253 A255 P256 F257 F280 A281 G282 S283 T285 D301 I302 Y306 S17 S35 P37 K40 H151 A153 P154 F155 F178 A179 G180 S181 T183 D199 I200 Y204 0003677,0008170,0009307,0015667 37414145 401 QKKKLKSFTNKYVVLDSLEGLRSLPDNSVQCVVTSPPYNKMNEDDYQKWQLQILNEINRILKPGGSAFYNHKPPEKFLSDSDLELYQTIIWDRGSTVNQNARYFRPYVEKIFWFTKSISGESTTPKFHRDRLPEYFKGVIWRIPPDKRNKHPAPFPAILAEICILTTTEEGDLVLDPFAGSGTTLVAAASLKRSYLGFDISSKYQKMFHQRLATSKSKVHLWL 8urk A 2.11 BS06 SFG A 1 D40 D59 Y68 S72 H214 T216 Q217 K218 F241 M242 S244 T246 Y261 E262 I263 Y267 D11 D30 Y39 S43 H185 T187 Q188 K189 F212 M213 S215 T217 Y232 E233 I234 Y238 A0A8I1DKW0 39244607 802 LPSGIELHNRDFLTDAAHLPDASIDLIVADPPYGLGKDYGNDSDKRSGDDFLAWTREWLELAIPKLKPSGSMYIFCTWQYAPEIFSFLKTQLTMVNEIIWDRRVPSMGGTTRRFTSVHDNIGFFAVSRAYYFDLDPVRIPYDADTKKARSRKLFEGSKWLEMGYNPKDVWSVSRLHRQHAERVDHPTQKPLEIIERMVLASCPPGGRVLDPFMGSGTTAVACARQGRDFVGYEINESYCAIAHERVNAL 8urk B 2.11 BS06 SFG B 1 R39 D40 D59 Y68 S72 H214 T216 F241 G243 S244 T246 Y261 E262 I263 Y267 R10 D11 D30 Y39 S43 H185 T187 F212 G214 S215 T217 Y232 E233 I234 Y238 A0A8I1DKW0 39244607 601 LPSGIELHNRDFLTDAAHLPDASIDLIVADPPYGLGKDYGNDSDKRSGDDFLAWTREWLELAIPKLKPSGSMYIFCTWQYAPEIFSFLKTQLTMVNEIIWDRRVPSMGGTTRRFTSVHDNIGFFAVSRAYYFDLDPVRIPYDADTKKARSRKLFEGSKWLEMGYNPKDVWSVSRLHRQHAERVDHPTQKPLEIIERMVLASCPPGGRVLDPFMGSGTTAVACARQGRDFVGYEINESYCAIAHERVNAL 8urk C 2.11 BS04 SFG C 1 D40 D59 Y68 N70 S72 H214 T216 F241 M242 S244 T246 Y261 E262 I263 Y267 D11 D30 Y39 N41 S43 H185 T187 F212 M213 S215 T217 Y232 E233 I234 Y238 A0A8I1DKW0 39244607 601 LPSGIELHNRDFLTDAAHLPDASIDLIVADPPYGLGKDYGNDSDKRSGDDFLAWTREWLELAIPKLKPSGSMYIFCTWQYAPEIFSFLKTQLTMVNEIIWDRRVPSMGGTTRRFTSVHDNIGFFAVSRAYYFDLDPVRIPYDADTKKARSRKLFEGSKWLEMGYNPKDVWSVSRLHRQHAERVDHPTQKPLEIIERMVLASCPPGGRVLDPFMGSGTTAVACARQGRDFVGYEINESYCAIAHERVNAL 8urk D 2.11 BS04 SFG D 1 R39 D40 D59 Y68 S72 H214 T216 K218 F241 M242 G243 S244 Y261 E262 I263 Y267 R6 D7 D26 Y35 S39 H181 T183 K185 F208 M209 G210 S211 Y228 E229 I230 Y234 A0A8I1DKW0 39244607 601 IELHNRDFLTDAAHLPDASIDLIVADPPYGLGKDYGNDSDKRSGDDFLAWTREWLELAIPKLKPSGSMYIFCTWQYAPEIFSFLKTQLTMVNEIIWDRRVPSMGGTTRRFTSVHDNIGFFAVSRAYYFDLDPVRIPYDADTKKARSRKLFEGSKWLEMGYNPKDVWSVSRLHRQHAERVDHPTQKPLEIIERMVLASCPPGGRVLDPFMGSGTTAVACARQGRDFVGYEINESYCAIAHERVNA 8x46 A 2.2 BS01 SFG A 1 I42 G43 H45 G72 G74 I92 E93 I94 D117 A118 N132 P134 Y135 I21 G22 H24 G51 G53 I71 E72 I73 D96 A97 N111 P113 Y114 O59487 39146930 301 KMRDRLFFLLSKYGIRPRDSIGQHFLIIEDVIEKAIETANVNENDVILEVGPGLGFLTDELAKRAKKVYTIEIDQKIIEILKKEYSWNNVKIIQGDAVRVEWPKFNKVVSNIPYKISSPFTFKLLKTDFERAVVMYQLEFALRMVAKPGSRNYSRLSLMAQALGNVEIVMKIGKGAFYPRPKVDSALVLIEPRKDKIVLNENLVKALFQHRRKTVPRALKDSIHMLGVSKDEIRGIINNVPHSNKRVFQLYPEEVKDIEEYLKKHGIIS 8x46 B 2.2 BS01 SFG B 1 I42 G43 H45 G72 G74 I92 E93 I94 D117 A118 N132 P134 Y135 I21 G22 H24 G51 G53 I71 E72 I73 D96 A97 N111 P113 Y114 O59487 39146930 301 KMRDRLFFLLSKYGIRPRDSIGQHFLIIEDVIEKAIETANVNENDVILEVGPGLGFLTDELAKRAKKVYTIEIDQKIIEILKKEYSWNNVKIIQGDAVRVEWPKFNKVVSNIPYKISSPFTFKLLKTDFERAVVMYQLEFALRMVAKPGSRNYSRLSLMAQALGNVEIVMKIGKGAFYPRPKVDSALVLIEPRKDKIVLNENLVKALFQHRRKTVPRALKDSIHMLGVSKDEIRGIINNVPHSNKRVFQLYPEEVKDIEEYLKKHGIIS 8x4p A 2.6 BS01 SFG A 1 Q44 H45 G72 G74 I92 E93 I94 D117 A118 N132 I133 P134 A135 Q24 H25 G52 G54 I72 E73 I74 D97 A98 N112 I113 P114 A115 O59487 39146930 305 SKMRDRLFFLLSKYGIRPRDSIGQHFLIIEDVIEKAIETANVNENDVILEVGPGLGFLTDELAKRAKKVYTIEIDQKIIEILKKEYSWNNVKIIQGDAVRVEWPKFNKVVSNIPAKISSPFTFKLLKTDFERAVVMYQLEFALRMVAKPGSRNYSRLSLMAQALGNVEIVMKIGKGAFYPRPKVDSALVLIEPRKDKIVLNENLVKALFQHRRKTVPRALKDSIHMLGVSKDEIRGIINNVPHSNKRVFQLYPEEVKDIEEYLKKHGIIS 8x4p B 2.6 BS01 SFG B 1 Q44 H45 G72 I92 E93 I94 D117 A118 N132 I133 P134 A135 Q24 H25 G52 I72 E73 I74 D97 A98 N112 I113 P114 A115 O59487 39146930 301 SKMRDRLFFLLSKYGIRPRDSIGQHFLIIEDVIEKAIETANVNENDVILEVGPGLGFLTDELAKRAKKVYTIEIDQKIIEILKKEYSWNNVKIIQGDAVRVEWPKFNKVVSNIPAKISSPFTFKLLKTDFERAVVMYQLEFALRMVAKPGSRNYSRLSLMAQALGNVEIVMKIGKGAFYPRPKVDSALVLIEPRKDKIVLNENLVKALFQHRRKTVPRALKDSIHMLGVSKDEIRGIINNVPHSNKRVFQLYPEEVKDIEEYLKKHGIIS 9c3s A 2.16 BS05 SFG A 1 D40 D59 Y68 S72 H214 T216 F241 M242 S244 T246 Y261 E262 I263 Y267 D11 D30 Y39 S43 H185 T187 F212 M213 S215 T217 Y232 E233 I234 Y238 A0A8I1DKW0 39244607 301 LPSGIELHNRDFLTDAAHLPDASIDLIVADPPYGLGKDYGNDSDKRSGDDFLAWTREWLELAIPKLKPSGSMYIFCTWQYAPEIFSFLKTQLTMVNEIIWDRRVPSMGGTTRRFTSVHDNIGFFAVSRAYYFDLDPVRIPYDADTKKARSRKLFEGSKWLEMGYNPKDVWSVSRLHRQHAERVDHPTQKPLEIIERMVLASCPPGGRVLDPFMGSGTTAVACARQGRDFVGYEINESYCAIAHERVNALA 9c3s B 2.16 BS06 SFG B 1 D40 D59 Y68 S72 H214 F241 M242 G243 S244 T246 E262 I263 D11 D30 Y39 S43 H185 F212 M213 G214 S215 T217 E233 I234 A0A8I1DKW0 39244607 301 LPSGIELHNRDFLTDAAHLPDASIDLIVADPPYGLGKDYGNDSDKRSGDDFLAWTREWLELAIPKLKPSGSMYIFCTWQYAPEIFSFLKTQLTMVNEIIWDRRVPSMGGTTRRFTSVHDNIGFFAVSRAYYFDLDPVRIPYDADTKKARSRKLFEGSKWLEMGYNPKDVWSVSRLHRQHAERVDHPTQKPLEIIERMVLASCPPGGRVLDPFMGSGTTAVACARQGRDFVGYEINESYCAIAHERVNAL 9c3s C 2.16 BS05 SFG C 1 D40 D59 S72 H214 Q217 K218 F241 M242 S244 T246 Y261 E262 I263 Y267 D5 D24 S37 H179 Q182 K183 F206 M207 S209 T211 Y226 E227 I228 Y232 A0A8I1DKW0 39244607 301 LHNRDFLTDAAHLPDASIDLIVADPPYGLGKDYGNDSDKRSGDDFLAWTREWLELAIPKLKPSGSMYIFCTWQYAPEIFSFLKTQLTMVNEIIWDRRVPSMGGTTRRFTSVHDNIGFFAVSRAYYFDLDPVRIPYDADTKKARSRKLFEGSKWLEMGYNPKDVWSVSRLHRQHAERVDHPTQKPLEIIERMVLASCPPGGRVLDPFMGSGTTAVACARQGRDFVGYEINESYCAIAHERVNALA 9c3s D 2.16 BS04 SFG D 1 D40 D59 S72 H214 T216 K218 F241 M242 S244 E262 I263 Y267 D4 D23 S36 H178 T180 K182 F205 M206 S208 E226 I227 Y231 A0A8I1DKW0 39244607 301 HNRDFLTDAAHLPDASIDLIVADPPYGLGKDYGNDSDKRSGDDFLAWTREWLELAIPKLKPSGSMYIFCTWQYAPEIFSFLKTQLTMVNEIIWDRRVPSMGGTTRRFTSVHDNIGFFAVSRAYYFDLDPVRIPYDADTKKARSRKLFEGSKWLEMGYNPKDVWSVSRLHRQHAERVDHPTQKPLEIIERMVLASCPPGGRVLDPFMGSGTTAVACARQGRDFVGYEINESYCAIAHERVNA 9c3t A 2.37 BS05 SFG A 1 D40 F41 D59 Y68 S72 H214 T216 F241 M242 G243 S244 Y261 E262 I263 Y267 D11 F12 D30 Y39 S43 H185 T187 F212 M213 G214 S215 Y232 E233 I234 Y238 A0A8I1DKW0 39244607 301 LPSGIELHNRDFLTDAAHLPDASIDLIVADPPYGLGKDYGNDSDKRSGDDFLAWTREWLELAIPKLKPSGSMYIFCTWQYAPEIFSFLKTQLTMVNEIIWDRRVPSMGGTTRRFTSVHDNIGFFAVSRAYYFDLDPVRIPYDADTKKARSRKLFEGSKWLEMGYNPKDVWSVSRLHRQHAERVDHPTQKPLEIIERMVLASCPPGGRVLDPFMGSGTTAVACARQGRDFVGYEINESYCAIAHERVNAL 9c3t B 2.37 BS05 SFG B 1 D40 D59 Y68 S72 H214 T216 F241 M242 G243 S244 T246 E262 I263 Y267 D11 D30 Y39 S43 H185 T187 F212 M213 G214 S215 T217 E233 I234 Y238 A0A8I1DKW0 39244607 301 LPSGIELHNRDFLTDAAHLPDASIDLIVADPPYGLGKDYGNDSDKRSGDDFLAWTREWLELAIPKLKPSGSMYIFCTWQYAPEIFSFLKTQLTMVNEIIWDRRVPSMGGTTRRFTSVHDNIGFFAVSRAYYFDLDPVRIPYDADTKKARSRKLFEGSKWLEMGYNPKDVWSVSRLHRQHAERVDHPTQKPLEIIERMVLASCPPGGRVLDPFMGSGTTAVACARQGRDFVGYEINESYCAIAHERVNAL 9c3t C 2.37 BS04 SFG C 1 D40 F41 D59 Y68 N70 S72 H214 Q217 F241 M242 G243 S244 T246 Y261 E262 I263 Y267 D11 F12 D30 Y39 N41 S43 H185 Q188 F212 M213 G214 S215 T217 Y232 E233 I234 Y238 A0A8I1DKW0 39244607 301 LPSGIELHNRDFLTDAAHLPDASIDLIVADPPYGLGKDYGNDSDKRSGDDFLAWTREWLELAIPKLKPSGSMYIFCTWQYAPEIFSFLKTQLTMVNEIIWDRRVPSMGGTTRRFTSVHDNIGFFAVSRAYYFDLDPVRIPYDADTKKARSRKLFEGSKWLEMGYNPKDVWSVSRLHRQHAERVDHPTQKPLEIIERMVLASCPPGGRVLDPFMGSGTTAVACARQGRDFVGYEINESYCAIAHERVNALA 9c3t D 2.37 BS04 SFG D 1 D40 D59 Y68 S72 H214 F241 M242 G243 S244 T246 Y261 E262 I263 Y267 D7 D26 Y35 S39 H181 F208 M209 G210 S211 T213 Y228 E229 I230 Y234 A0A8I1DKW0 39244607 301 IELHNRDFLTDAAHLPDASIDLIVADPPYGLGKDYGNDSDKRSGDDFLAWTREWLELAIPKLKPSGSMYIFCTWQYAPEIFSFLKTQLTMVNEIIWDRRVPSMGGTTRRFTSVHDNIGFFAVSRAYYFDLDPVRIPYDADTKKARSRKLFEGSKWLEMGYNPKDVWSVSRLHRQHAERVDHPTQKPLEIIERMVLASCPPGGRVLDPFMGSGTTAVACARQGRDFVGYEINESYCAIAHERVNA 9c3u A 2.77 BS05 SFG A 1 D40 F41 D59 Y68 S72 H214 K218 F241 S244 T246 Y261 E262 I263 Y267 D11 F12 D30 Y39 S42 H184 K188 F211 S214 T216 Y231 E232 I233 Y237 A0A8I1DKW0 39244607 301 LPSGIELHNRDFLTDAAHLPDASIDLIVADPPYGLGKDYNDSDKRSGDDFLAWTREWLELAIPKLKPSGSMYIFCTWQYAPEIFSFLKTQLTMVNEIIWDRRVPSMGGTTRRFTSVHDNIGFFAVSRAYYFDLDPVRIPYDADTKKARSRKLFEGSKWLEMGYNPKDVWSVSRLHRQHAERVDHPTQKPLEIIERMVLASCPPGGRVLDPFMGSGTTAVACARQGRDFVGYEINESYCAIAHERVNAL 9c3u B 2.77 BS06 SFG B 1 D40 D59 Y68 S72 H214 F241 M242 G243 S244 T246 Y261 E262 I263 Y267 D11 D30 Y39 S43 H185 F212 M213 G214 S215 T217 Y232 E233 I234 Y238 A0A8I1DKW0 39244607 301 LPSGIELHNRDFLTDAAHLPDASIDLIVADPPYGLGKDYGNDSDKRSGDDFLAWTREWLELAIPKLKPSGSMYIFCTWQYAPEIFSFLKTQLTMVNEIIWDRRVPSMGGTTRRFTSVHDNIGFFAVSRAYYFDLDPVRIPYDADTKKARSRKLFEGSKWLEMGYNPKDVWSVSRLHRQHAERVDHPTQKPLEIIERMVLASCPPGGRVLDPFMGSGTTAVACARQGRDFVGYEINESYCAIAHERVNAL 9c3u C 2.77 BS05 SFG C 1 D40 D59 S72 H214 T216 Q217 K218 F241 S244 T246 E262 I263 Y267 D9 D28 S36 H175 T177 Q178 K179 F202 S205 T207 E222 I223 Y227 A0A8I1DKW0 39244607 301 SGIELHNRDFLTDAAHLPDASIDLIVADPPYGLNDSDKRSGDDFLAWTREWLELAIPLKPSGSMYIFCTWQYAPEIFSKTQLTMVNEIIWDRRVPSMGGTTRRFTSVHDNIGFFAVSRAYYFDLDPVRIPYDADTKKARSRKLFEGSKWLEMGYNPKDVWSVSRLHRQHAERVDHPTQKPLEIIERMVLASCPPGGRVLDPFMGSGTTAACARQGRDFVGYEINESYCAIAHERVNAL 9c3u D 2.77 BS05 SFG D 1 D40 D59 H214 T216 F241 M242 G243 S244 Y261 E262 I263 D4 D22 H177 T179 F204 M205 G206 S207 Y224 E225 I226 A0A8I1DKW0 39244607 301 HNRDFLTDAAHLPDSIDLIVADPPYGLGKDYGNDSDKRSGDDFLAWTREWLELAIPKLKPSGSMYIFCTWQYAPEIFSFLKTQLTMVNEIIWDRRVPSMGGTTRRFTSVHDNIGFFAVSRAYYFDLDPVRIPYDADTKKARSRKLFEGSKWLEMGYNPKDVWSVSRLHRQHAERVDHPTQKPLEIIERMVLASCPPGGRVLDPFMGSGTTAVACARQGRDFVGYEINEYCAIAHERVN