1a9u A 2.5 BS01 SB2 A 1 Y35 A51 K53 L104 V105 T106 M109 R173 Y32 A48 K50 L101 V102 T103 M106 R170 D150 K152 N155 D168 T185 D147 K149 N152 D165 T182 2.7.11.24 0000077,0000165,0000902,0000922,0001502,0001525,0001649,0001890,0002021,0002062,0002862,0004672,0004674,0004707,0004708,0005515,0005524,0005576,0005634,0005654,0005737,0005739,0005829,0006006,0006355,0006357,0006366,0006468,0006915,0006935,0006974,0007165,0007166,0007178,0007519,0010628,0010831,0016301,0016310,0016607,0018105,0019395,0019899,0019903,0030168,0030278,0030316,0031098,0031281,0031663,0032495,0032496,0032735,0032868,0033554,0034774,0035331,0035556,0035924,0035994,0038066,0042307,0042770,0043536,0045648,0045663,0045944,0046323,0046326,0048010,0048273,0048863,0051146,0051149,0051403,0051525,0060045,0060348,0070935,0071222,0071223,0071356,0071479,0071493,0090090,0090336,0090398,0090400,0098586,0098978,0099179,0106310,1900015,1901741,1904813,2000379 -logKd/Ki=7.32, IC50=0.048uM Q16539 9753691 800 ERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLD 1pme A 2.0 BS01 SB2 A 1 A52 L103 V104 T105 H106 L107 M108 K151 S153 N154 L156 A34 L85 V86 T87 H88 L89 M90 K133 S135 N136 L138 D149 K151 S153 N154 D167 T190 D131 K133 S135 N136 D149 T172 2.7.11.24 0000165,0001784,0003677,0004672,0004674,0004707,0005515,0005524,0005576,0005634,0005654,0005737,0005739,0005769,0005770,0005788,0005794,0005813,0005819,0005829,0005856,0005886,0005901,0005925,0006357,0006468,0006915,0006935,0006974,0007165,0007166,0007268,0007507,0007611,0008286,0008353,0009887,0010759,0010800,0014032,0014044,0016020,0016301,0016310,0018105,0018107,0019858,0019902,0030278,0030521,0030641,0030878,0031143,0031647,0031663,0032206,0032496,0032872,0033554,0033598,0034198,0035094,0035556,0035578,0038127,0038133,0042473,0042552,0042802,0043330,0043401,0045202,0045542,0045596,0048009,0048538,0050847,0050852,0050853,0051403,0051493,0060020,0060291,0060324,0060425,0060440,0060716,0061308,0070161,0070371,0070849,0071356,0072584,0072686,0090170,0106310,0120041,1904813,2000641 Ki=0.76nM -logKd/Ki=9.40, Ki=0.4nM P28482 9827991 1001 GQVFDVGPRYTNLSYIGYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYLVTHLMGADLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFLPKEKLKELIFEETARFQPGYRS 2ewa A 2.1 BS01 SB2 A 1 Y35 V38 A51 K53 I84 L104 V105 T106 M109 F169 G170 Y31 V34 A47 K49 I80 L100 V101 T102 M105 F160 G161 D150 K152 N155 D168 T185 D141 K143 N146 D159 T162 2.7.11.24 0000077,0000165,0000902,0000922,0001502,0001525,0001649,0001890,0002021,0002062,0004672,0004674,0004707,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006006,0006355,0006357,0006366,0006468,0006915,0006974,0007178,0007519,0010628,0010831,0016301,0016310,0016607,0018105,0019395,0019899,0019903,0030278,0030316,0031098,0031281,0031663,0032495,0032496,0032735,0032868,0035331,0035556,0035924,0035994,0038066,0042307,0042770,0045648,0045663,0045944,0046323,0046326,0048010,0048273,0048863,0051146,0051403,0051525,0060045,0060348,0071222,0071223,0071356,0071479,0071493,0090090,0090336,0090400,0098586,0098978,0099179,0106310,1900015,1901741,2000379 -logKd/Ki=7.94, Kd=11.5nM P47811 16374788 361 RPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNILTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGTRWYRAPEIMLNMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLD 3gcp A 2.25 BS01 SB2 A 1 Y35 A51 K53 L104 V105 T106 L108 M109 F169 L171 Y32 A48 K50 L101 V102 T103 L105 M106 F166 L168 D150 K152 N155 D168 T185 D147 K149 N152 D165 T170 2.7.11.24 0000077,0000165,0000902,0000922,0001502,0001525,0001649,0001890,0002021,0002062,0002862,0004672,0004674,0004707,0004708,0005515,0005524,0005576,0005634,0005654,0005737,0005739,0005829,0006006,0006355,0006357,0006366,0006468,0006915,0006935,0006974,0007165,0007166,0007178,0007519,0010628,0010831,0016301,0016310,0016607,0018105,0019395,0019899,0019903,0030168,0030278,0030316,0031098,0031281,0031663,0032495,0032496,0032735,0032868,0033554,0034774,0035331,0035556,0035924,0035994,0038066,0042307,0042770,0043536,0045648,0045663,0045944,0046323,0046326,0048010,0048273,0048863,0051146,0051149,0051403,0051525,0060045,0060348,0070935,0071222,0071223,0071356,0071479,0071493,0090090,0090336,0090398,0090400,0098586,0098978,0099179,0106310,1900015,1901741,1904813,2000379 Kd=15nM -logKd/Ki=7.82, Kd=15nM Q16539 19572644 361 ERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKSQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDSELKILDFGLCTRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSLESRDLLIDEWKSLTYDEVISFVPPP 3mpa A 2.1 BS01 SB2 A 1 A51 K53 L104 V105 T106 M109 L167 A44 K46 L97 V98 T99 M102 L160 D150 K152 N155 G168 T185 D143 K145 N148 G161 T164 2.7.11.24 0000077,0000165,0000902,0000922,0001502,0001525,0001649,0001890,0002021,0002062,0002862,0004672,0004674,0004707,0004708,0005515,0005524,0005576,0005634,0005654,0005737,0005739,0005829,0006006,0006355,0006357,0006366,0006468,0006915,0006935,0006974,0007165,0007166,0007178,0007519,0010628,0010831,0016301,0016310,0016607,0018105,0019395,0019899,0019903,0030168,0030278,0030316,0031098,0031281,0031663,0032495,0032496,0032735,0032868,0033554,0034774,0035331,0035556,0035924,0035994,0038066,0042307,0042770,0043536,0045648,0045663,0045944,0046323,0046326,0048010,0048273,0048863,0051146,0051149,0051403,0051525,0060045,0060348,0070935,0071222,0071223,0071356,0071479,0071493,0090090,0090336,0090398,0090400,0098586,0098978,0099179,0106310,1900015,1901741,1904813,2000379 Q16539 361 RPTFYRQELNKTIWEVPERYQNLSPVGSGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILGFGTRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPP 3obg A 2.8 BS01 SB2 A 1 V38 A51 K53 L104 T106 L108 M109 D168 V30 A43 K45 L96 T98 L100 M101 D160 D150 K152 N155 D168 T185 D142 K144 N147 D160 T165 2.7.11.24 0000077,0000165,0000902,0000922,0001502,0001525,0001649,0001890,0002021,0002062,0002862,0004672,0004674,0004707,0004708,0005515,0005524,0005576,0005634,0005654,0005737,0005739,0005829,0006006,0006355,0006357,0006366,0006468,0006915,0006935,0006974,0007165,0007166,0007178,0007519,0010628,0010831,0016301,0016310,0016607,0018105,0019395,0019899,0019903,0030168,0030278,0030316,0031098,0031281,0031663,0032495,0032496,0032735,0032868,0033554,0034774,0035331,0035556,0035924,0035994,0038066,0042307,0042770,0043536,0045648,0045663,0045944,0046323,0046326,0048010,0048273,0048863,0051146,0051149,0051403,0051525,0060045,0060348,0070935,0071222,0071223,0071356,0071479,0071493,0090090,0090336,0090398,0090400,0098586,0098978,0099179,0106310,1900015,1901741,1904813,2000379 Q16539 361 RPTFYRQELNKTIWEVPERYQNLSPVGGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDGGLATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPP 3uib A 2.65 BS01 SB2 A 1 A49 T112 M115 H160 L165 C175 D176 A29 T74 M77 H122 L127 C137 D138 D158 H160 N163 D176 H195 D120 H122 N125 D138 H145 2.7.11.1 0004672,0005524,0006468 -logKd/Ki=6.80, Kd=0.16uM Q4QHJ8 22884419 362 AAMRDLIAELVQRYGAVCAGVDSEGIPVAIKRVFNTNILSDSFLCKRVLREIRLLNHFHHPNILGLRDILYLVTELMRTDLAQVIHDQRIVISPQHIQYFMYHILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLYVTHRWYRAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIEDVVMFSSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRISTEQALRHPYFESLFDPLDLTEGLSERFHFDESVTDVYDMHKIFTAEVERF 3zs5 A 1.6 BS01 SB2 A 1 Y35 A51 K53 L104 V105 T106 M109 F169 G170 Y35 A51 K53 L104 V105 T106 M109 F169 G170 D150 K152 N155 D168 T185 D150 K152 N155 D168 T173 2.7.11.24 0000077,0000165,0000902,0000922,0001502,0001525,0001649,0001890,0002021,0002062,0002862,0004672,0004674,0004707,0004708,0005515,0005524,0005576,0005634,0005654,0005737,0005739,0005829,0006006,0006355,0006357,0006366,0006468,0006915,0006935,0006974,0007165,0007166,0007178,0007519,0010628,0010831,0016301,0016310,0016607,0018105,0019395,0019899,0019903,0030168,0030278,0030316,0031098,0031281,0031663,0032495,0032496,0032735,0032868,0033554,0034774,0035331,0035556,0035924,0035994,0038066,0042307,0042770,0043536,0045648,0045663,0045944,0046323,0046326,0048010,0048273,0048863,0051146,0051149,0051403,0051525,0060045,0060348,0070935,0071222,0071223,0071356,0071479,0071493,0090090,0090336,0090398,0090400,0098586,0098978,0099179,0106310,1900015,1901741,1904813,2000379 Q16539 22868770 1000 HSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPP 5ar4 A 2.7 BS01 SB2 A 1 R26 V32 A45 K47 L79 I93 T95 Y97 M98 Q150 L153 D164 R22 V28 A41 K43 L70 I84 T86 Y88 M89 Q141 L144 D155 D146 K148 Q150 N151 D164 T189 D137 K139 Q141 N142 D155 T159 2.7.10.2,2.7.11.1 0004672,0005524,0006468 -logKd/Ki=6.70, IC50=200nM O43353 26455654 1311 AICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLTIIYMPPENYEASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLK 5ar4 B 2.7 BS01 SB2 B 1 R26 V32 A45 K47 L79 I93 T95 M98 L153 D164 R21 V27 A40 K42 L68 I82 T84 M87 L142 D153 D146 K148 Q150 N151 D164 T189 D135 K137 Q139 N140 D153 T158 2.7.10.2,2.7.11.1 0004672,0005524,0006468 O43353 26455654 1311 ICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLK 8acm AAA 2.14 BS04 SB2 AAA 1 Y35 A51 K53 L104 V105 T106 M109 S154 L167 D168 Y32 A48 K50 L101 V102 T103 M106 S151 L164 D165 2.7.11.24 0000077,0000165,0000902,0000922,0001502,0001525,0001649,0001890,0002021,0002062,0004672,0004674,0004707,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006006,0006355,0006357,0006366,0006468,0006915,0006974,0007178,0007519,0010628,0010831,0016301,0016310,0016607,0018105,0019395,0019899,0019903,0030278,0030316,0031098,0031281,0031663,0032495,0032496,0032735,0032868,0035331,0035556,0035924,0035994,0038066,0042307,0042770,0045648,0045663,0045944,0046323,0046326,0048010,0048273,0048863,0051146,0051403,0051525,0060045,0060348,0071222,0071223,0071356,0071479,0071493,0090090,0090336,0090400,0098586,0098978,0099179,0106310,1900015,1901741,2000379 P47811 404 ERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLTRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPL 8aco AAA 2.65 BS01 SB2 AAA 1 Y35 A51 K53 L104 T106 L108 M109 S154 D168 Y32 A48 K50 L101 T103 L105 M106 S151 D165 2.7.11.24 0000077,0000165,0000902,0000922,0001502,0001525,0001649,0001890,0002021,0002062,0004672,0004674,0004707,0005515,0005524,0005634,0005654,0005737,0005739,0005829,0006006,0006355,0006357,0006366,0006468,0006915,0006974,0007178,0007519,0010628,0010831,0016301,0016310,0016607,0018105,0019395,0019899,0019903,0030278,0030316,0031098,0031281,0031663,0032495,0032496,0032735,0032868,0035331,0035556,0035924,0035994,0038066,0042307,0042770,0045648,0045663,0045944,0046323,0046326,0048010,0048273,0048863,0051146,0051403,0051525,0060045,0060348,0071222,0071223,0071356,0071479,0071493,0090090,0090336,0090400,0098586,0098978,0099179,0106310,1900015,1901741,2000379 P47811 401 ERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFTRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPP