13gs A 1.9 BS02 SAS A 1 F8 P9 V10 R13 V35 I104 Y108 P202 G205 F9 P10 V11 R14 V36 I105 Y109 P203 G206 Y7 R13 Y8 R14 2.5.1.18 0000302,0002674,0004364,0004602,0005504,0005515,0005576,0005615,0005634,0005737,0005739,0005829,0006469,0006629,0006693,0006749,0006805,0007417,0008432,0009890,0010804,0016740,0019207,0031982,0032691,0032720,0032872,0032873,0032930,0034774,0035726,0035730,0035731,0035732,0043066,0043124,0043407,0043409,0043508,0043651,0048147,0051122,0051771,0070026,0070062,0070372,0070373,0070664,0071222,0071638,0097057,0098869,1901687,1904813,2001237 Ki=24uM -logKd/Ki=4.62, Ki=24uM P09211 10452896 211 MPPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGDLTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYVKALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAYVGRLSARPKLKAFLASPEYVNLPINGNGKQ 13gs B 1.9 BS02 SAS B 1 F8 P9 V10 R13 V35 I104 Y108 P202 G205 F7 P8 V9 R12 V34 I103 Y107 P201 G204 Y7 R13 Y6 R12 2.5.1.18 0000302,0002674,0004364,0004602,0005504,0005515,0005576,0005615,0005634,0005737,0005739,0005829,0006469,0006629,0006693,0006749,0006805,0007417,0008432,0009890,0010804,0016740,0019207,0031982,0032691,0032720,0032872,0032873,0032930,0034774,0035726,0035730,0035731,0035732,0043066,0043124,0043407,0043409,0043508,0043651,0048147,0051122,0051771,0070026,0070062,0070372,0070373,0070664,0071222,0071638,0097057,0098869,1901687,1904813,2001237 Ki=24uM P09211 10452896 211 PYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGDLTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYVKALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAYVGRLSARPKLKAFLASPEYVNLPINGNGKQ 4j7x A 2.6 BS02 SAS A 1 S154 L155 F161 W164 Y167 P197 S154 L155 F161 W164 Y167 P197 1.1.1.153 0004033,0004757,0005654,0005737,0005739,0005829,0006729,0006809,0016491,0050661,0070062 P35270 806 GLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQVNNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDMLFQVLALEEPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSAQKLLSLLEKDEFKSGAHVDFYD 4j7x B 2.6 BS02 SAS B 1 S154 L155 F161 Y167 G196 P197 D214 M215 S154 L155 F161 Y167 G196 P197 D214 M215 1.1.1.153 0004033,0004757,0005654,0005737,0005739,0005829,0006729,0006809,0016491,0050661,0070062 P35270 804 GLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQVNNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDMLFQVLALEEPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSAQKLLSLLEKDEFKSGAHVDFYD 4j7x F 2.6 BS02 SAS F 1 S154 L155 F161 Y167 P197 D214 M215 S154 L155 F161 Y167 P197 D214 M215 1.1.1.153 0004033,0004757,0005654,0005737,0005739,0005829,0006729,0006809,0016491,0050661,0070062 P35270 805 GLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQVNNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDMLFQVLALEEPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSAQKLLSLLEKDEFKSGAHVDFYD 4j7x J 2.6 BS02 SAS J 1 S154 L155 Y167 P197 D214 M215 S154 L155 Y167 P197 D214 M215 1.1.1.153 0004033,0004757,0005654,0005737,0005739,0005829,0006729,0006809,0016491,0050661,0070062 P35270 804 GLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDSTQVNNYWALNLTSMLCLTSSVLKAFPDSPGLNRTVVNISSLCALQPFKGWALYCAGKAARDMLFQVLALEEPNVRVLNYAPGPLDTDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSAQKLLSLLEKDEFKSGAHVDFYD 5acl A 1.49 BS01 SAS A 1 Y34 S36 Y51 E52 P57 F99 Y33 S35 Y50 E51 P56 F98 ? 0002250,0003823,0005576,0005615,0005886,0006955,0019814 P01709 26576950 1111 SALTQPPSASGSLGQSVTISCTGTSSDVGGYNYVSWYQQHAGKAPKVIIYEVNKRPSGVPDRFSGSKSGNTASLTVSGLQAEDEADYYCSSYEGSDNFVFGTGTKVTVL 6g0g A 1.478 BS01 SAS A 1 W81 P82 L92 D145 M149 W39 P40 L50 D103 M107 ? O60885 204 MNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTE 6r7s A 2.21 BS01 SAS A 1 L198 K199 S202 F211 W214 R218 L238 S287 I290 A291 L182 K183 S186 F195 W198 R202 L222 S271 I274 A275 ? 0003677,0005504,0005507,0005515,0005576,0005615,0005634,0005737,0005783,0005788,0005794,0008289,0009267,0015643,0016209,0019825,0030170,0031093,0032991,0042802,0046872,0051087,0051902,0070062,0072562,0072732,0098869,0140272,1903981 P02768 32162429 604 SEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTDCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAAL 6r7s A 2.21 BS02 SAS A 2 L394 N405 V409 R410 K541 L544 K545 M548 L378 N389 V393 R394 K525 L528 K529 M532 ? 0003677,0005504,0005507,0005515,0005576,0005615,0005634,0005737,0005783,0005788,0005794,0008289,0009267,0015643,0016209,0019825,0030170,0031093,0032991,0042802,0046872,0051087,0051902,0070062,0072562,0072732,0098869,0140272,1903981 P02768 32162429 605 SEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTDCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAAL 6r7s A 2.21 BS03 SAS A 3 T506 F507 T508 K524 K525 T527 A528 E531 F551 A552 V555 T490 F491 T492 K508 K509 T511 A512 E515 F535 A536 V539 ? 0003677,0005504,0005507,0005515,0005576,0005615,0005634,0005737,0005783,0005788,0005794,0008289,0009267,0015643,0016209,0019825,0030170,0031093,0032991,0042802,0046872,0051087,0051902,0070062,0072562,0072732,0098869,0140272,1903981 P02768 32162429 606 SEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTDCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAAL 7er8 A 1.45 BS02 SAS A 1 F113 W116 P152 H153 R170 R174 Y200 F114 W117 P153 H154 R171 R175 Y201 1.3.1.-,1.5.1.30,2.6.99.- 0004074,0005515,0005654,0005737,0005829,0005886,0008752,0016491,0016740,0030219,0035605,0042167,0042602,0043231,0046627,0052873,0052874,0070062 P30043 34957824 402 HMAVKKIAIFGATGQTGLTTLAQAVQAGYEVTVLVRDSSRLPSEGPRPAHVVVGDVLQAADVDKTVAGQDAVIVLLGTRNDLSPTTVMSEGARNIVAAMKAHGVDKVVACTSAFLLWDPTKVPPRLQAVTDDHIRMHKVLRESGLKYVAVMPPHIGDQPLTGAYTVTLDGRGPSRVISKHDLGHFMLRCLTTDEYDGHSTYPSHQYQ 7er8 A 1.45 BS03 SAS B 1 E89 R134 E90 R135 1.3.1.-,1.5.1.30,2.6.99.- 0004074,0005515,0005654,0005737,0005829,0005886,0008752,0016491,0016740,0030219,0035605,0042167,0042602,0043231,0046627,0052873,0052874,0070062 P30043 34957824 402 HMAVKKIAIFGATGQTGLTTLAQAVQAGYEVTVLVRDSSRLPSEGPRPAHVVVGDVLQAADVDKTVAGQDAVIVLLGTRNDLSPTTVMSEGARNIVAAMKAHGVDKVVACTSAFLLWDPTKVPPRLQAVTDDHIRMHKVLRESGLKYVAVMPPHIGDQPLTGAYTVTLDGRGPSRVISKHDLGHFMLRCLTTDEYDGHSTYPSHQYQ 7er8 B 1.45 BS02 SAS B 1 N79 S111 F113 W116 R124 L125 H153 N79 S111 F113 W116 R124 L125 H153 1.3.1.-,1.5.1.30,2.6.99.- 0004074,0005515,0005654,0005737,0005829,0005886,0008752,0016491,0016740,0030219,0035605,0042167,0042602,0043231,0046627,0052873,0052874,0070062 P30043 34957824 402 MAVKKIAIFGATGQTGLTTLAQAVQAGYEVTVLVRDSSRLPSEGPRPAHVVVGDVLQAADVDKTVAGQDAVIVLLGTRNDLSPTTVMSEGARNIVAAMKAHGVDKVVACTSAFLLWDPTKVPPRLQAVTDDHIRMHKVLRESGLKYVAVMPPHIGDQPLTGAYTVTLDGRGPSRVISKHDLGHFMLRCLTTDEYDGHSTYPSHQYQ