1m6e X 3.0 BS02 SAL X 1 W151 W226 Y255 M308 V311 W151 W226 Y255 M308 V311 2.1.1.274 0008168,0008757,0032259,0046872 Q9SPV4 12897246 2000 MDVRQVLHMKGGAGENSYAMNSFIQRQVISITKPITEAAITALYSGDTVTTRLAIADLGCSSGPNALFAVTELIKTVEELRKKMGRENSPEYQIFLNDLPGNDFNAIFRSLPIENDVDGVCFINGVPGSFYGRLFPRNTLHFIHSSYSLMWLSQVPIGIESNKGNIYMANTCPQSVLNAYYKQFQEDHALFLRCRAQEVVPGGRMVLTILGRRSEDRASTECCLIWQLLAMALNQMVSEGLIEEEKMDKFNIPQYTPSPTEVEAEILKEGSFLIDHIEASEIYWSSCTKDGDGGGSVEEEGYNVARCMRAVAEPLLLDHFGEAIIEDVFHRYKLLIIERMSKEKTKFINVIVSLIRKSD 1pth A 3.4 BS02 SAL A 1 R120 V349 Y355 A527 X530 L531 R88 V317 Y323 A495 X498 L499 Q203 H207 L384 Y385 H388 G526 S530 Q171 H175 L352 Y353 H356 G494 S498 1.14.99.1 0001516,0004601,0004666,0005737,0005783,0005789,0006979,0008217,0016020,0016702,0019371,0020037,0042803,0043005,0043231,0046872,0051213,0098869 P05979 7552725 710 VNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPEIWTWLRTTLRPSPSFIHFLLTHGRWLWDFVNATFIRDTLMRLVLTVRSNLIPSPPTYNIAHDYISWESFSNVSYYTRILPSVPRDCPTPMGTKGKKQLPDAEFLSRRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQMLNGEVYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATIWLREHNRVCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGAQFQYRNRIAMEFNQLYHWHPLMPDSFRVGPQDYSYEQFLFNTSMLVDYGVEALVDAFSRQPAGRIGGGRNIDHHILHVAVDVIKESRVLRLQPFNEYRKRFGMKPYTSFQELTGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEMGAPFSLKGLLGNPICSPEYWKASTFGGEVGFNLVKTATLKKLVCLNTKTCPYVSFHVP 1pth B 3.4 BS02 SAL B 1 R120 V349 Y355 A527 X530 L531 R88 V317 Y323 A495 X498 L499 Q203 H207 L384 Y385 H388 G526 S530 Q171 H175 L352 Y353 H356 G494 S498 1.14.99.1 0001516,0004601,0004666,0005737,0005783,0005789,0006979,0008217,0016020,0016702,0019371,0020037,0042803,0043005,0043231,0046872,0051213,0098869 P05979 7552725 711 VNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPEIWTWLRTTLRPSPSFIHFLLTHGRWLWDFVNATFIRDTLMRLVLTVRSNLIPSPPTYNIAHDYISWESFSNVSYYTRILPSVPRDCPTPMGTKGKKQLPDAEFLSRRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQMLNGEVYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATIWLREHNRVCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGAQFQYRNRIAMEFNQLYHWHPLMPDSFRVGPQDYSYEQFLFNTSMLVDYGVEALVDAFSRQPAGRIGGGRNIDHHILHVAVDVIKESRVLRLQPFNEYRKRFGMKPYTSFQELTGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEMGAPFSLKGLLGNPICSPEYWKASTFGGEVGFNLVKTATLKKLVCLNTKTCPYVSFHVP 1y7i A 2.1 BS01 SAL A 1 A13 S81 L82 F107 Y122 W131 F151 H238 A11 S79 L80 F105 Y120 W129 F149 H236 G12 S81 L82 D210 H238 M239 G10 S79 L80 D208 H236 M237 3.1.1.- 0009694,0009696,0009862,0016298,0016787,0045087,0080030,0080031,0080032 Kd=90nM Q6RYA0 15668381 501 EGKHFVLVHGACHGGWSWYKLKPLLEAAGHKVTALDLAASGTDLRKIEELRTLYDYTLPLMELMESLSADEKVILVGHSLGGMNLGLAMEKYPQKIYAAVFLAAFMPDSVHNSSFVLEQYNERTPAENWLDTQFLPYGSPEEPLTSMFFGPKFLAHKLYQLCSPEDLALASSLVRPSSLFMEDLSKAKYFTDERFGSVKRVYIVCTEDKGIPEEFQRWQIDNIGVTEAIEIKGADHMAMLCEPQKLCASLLEIAHKYN 1y7i A 2.1 BS02 SAL A 2 L132 H158 K159 L130 H156 K157 G12 S81 L82 D210 H238 M239 G10 S79 L80 D208 H236 M237 3.1.1.- 0009694,0009696,0009862,0016298,0016787,0045087,0080030,0080031,0080032 Kd=90nM Q6RYA0 15668381 502 EGKHFVLVHGACHGGWSWYKLKPLLEAAGHKVTALDLAASGTDLRKIEELRTLYDYTLPLMELMESLSADEKVILVGHSLGGMNLGLAMEKYPQKIYAAVFLAAFMPDSVHNSSFVLEQYNERTPAENWLDTQFLPYGSPEEPLTSMFFGPKFLAHKLYQLCSPEDLALASSLVRPSSLFMEDLSKAKYFTDERFGSVKRVYIVCTEDKGIPEEFQRWQIDNIGVTEAIEIKGADHMAMLCEPQKLCASLLEIAHKYN 1y7i B 2.1 BS01 SAL B 1 A13 S81 L82 F107 H238 A11 S79 L80 F105 H236 G12 S81 L82 D210 H238 M239 G10 S79 L80 D208 H236 M237 3.1.1.- 0009694,0009696,0009862,0016298,0016787,0045087,0080030,0080031,0080032 Kd=90nM Q6RYA0 15668381 503 EGKHFVLVHGACHGGWSWYKLKPLLEAAGHKVTALDLAASGTDLRKIEELRTLYDYTLPLMELMESLSADEKVILVGHSLGGMNLGLAMEKYPQKIYAAVFLAAFMPDSVHNSSFVLEQYNERTPAENWLDTQFLPYGSPEEPLTSMFFGPKFLAHKLYQLCSPEDLALASSLVRPSSLFMEDLSKAKYFTDERFGSVKRVYIVCTEDKGIPEEFQRWQIDNIGVTEAIEIKGADHMAMLCEPQKLCASLLEIAHKYNLEHH 2i30 A 2.9 BS01 SAL A 1 F149 Y161 G189 F147 Y159 G187 ? 0003677,0005504,0005507,0005515,0005576,0005615,0005634,0005737,0005783,0005788,0005794,0008289,0009267,0015643,0016209,0019825,0030170,0031093,0032991,0042802,0046872,0051087,0051902,0070062,0072562,0072732,0098869,0140272,1903981 Ki=5888436553556nM P02768 17067818 1100 HKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALG 3b9m A 2.7 BS02 SAL A 1 I142 H146 Y161 R186 G189 I140 H144 Y159 R184 G187 ? 0003677,0005504,0005507,0005515,0005576,0005615,0005634,0005737,0005783,0005788,0005794,0008289,0009267,0015643,0016209,0019825,0030170,0031093,0032991,0042802,0046872,0051087,0051902,0070062,0072562,0072732,0098869,0140272,1903981 Ki=5888436553556nM P02768 18258455 1200 HKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALG 3w1w A 2.006 BS02 SAL A 1 P277 L311 P213 L247 M76 L92 L98 R164 Y165 H263 D340 E343 E347 M12 L28 L34 R100 Y101 H199 D276 E279 E283 4.98.1.1 0004325,0006783 P22830 24043703 1505 RKPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRLTPKIQEQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERDGLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADHILKELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLVWQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKECGVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRETKSFFTSQQL 5u6m A 2.568 BS03 SAL A 1 H18 F113 Q134 M183 T365 H13 F108 Q129 M178 T360 2.4.1.- 0005829,0008194,0009696,0010030,0016757,0018874,0035251,0046482,0052639,0052640,0052641,0080002,0090704 O22822 28425481 503 GHVLAVPYPTQGHITPFRQFCKRLHFKGLKTTLALTTFVFNSINPDLSGPISIATISDGYDHGGFETADSIDDYLKDFKTSGSKTIADIIQKHQTSDNPITCIVYDAFLPWALDVAREFGLVATPFFTQPCAVNYVYYLSYINNGSLQLPIEELPFLELQDLPSFFSVSGSYPAYFEMVLQQFINFEKADFVLVNSFQELELHENELWSKACPVLTIGPTIPSIYLDQRIKSDTGYDLNLFESKDDSFCINWLDTRPQGSVVYVAFGSMAQLTNVQMEELASAVSNFSFLWVVRSSEEEKLPSGFLETVNKEKSLVLKWSPQLQVLSNKAIGCFLTHCGWNSTMEALTFGVPMVAMPQWTDQPMNAKYIQDVWKAGVRVKTEKESGIAKREEIEFSIKEVMEGERSKEMKKNVKKWRDLAVKSLNEGGSTDTNIDTFVSRVQ 5u6m B 2.568 BS03 SAL B 1 H18 F113 Q134 T365 H15 F110 Q131 T362 2.4.1.- 0005829,0008194,0009696,0010030,0016757,0018874,0035251,0046482,0052639,0052640,0052641,0080002,0090704 O22822 28425481 503 KRGHVLAVPYPTQGHITPFRQFCKRLHFKGLKTTLALTTFVFNSINPDLSGPISIATISDGYDHGGFETADSIDDYLKDFKTSGSKTIADIIQKHQTSDNPITCIVYDAFLPWALDVAREFGLVATPFFTQPCAVNYVYYLSYINNGSLQLPIEELPFLELQDLPSFFSVSGSYPAYFEMVLQQFINFEKADFVLVNSFQELELHENELWSKACPVLTIGPTIPSIYLDQRIKSDTGYDLNLFESKDDSFCINWLDTRPQGSVVYVAFGSMAQLTNVQMEELASAVSNFSFLWVVRSSEEEKLPSGFLETVNKEKSLVLKWSPQLQVLSNKAIGCFLTHCGWNSTMEALTFGVPMVAMPQWTDQPMNAKYIQDVWKAGVRVKTEKESGIAKREEIEFSIKEVMEGERSKEMKKNVKKWRDLAVKSLNEGGSTDTNIDTFVSRVQS 5u6n A 2.001 BS06 SAL A 1 H18 F113 Q134 M274 T365 H14 F109 Q130 M270 T361 2.4.1.- 0005829,0008194,0009696,0010030,0016757,0018874,0035251,0046482,0052639,0052640,0052641,0080002,0090704 O22822 28425481 505 RGHVLAVPYPSQGHITPFRQFCKRLHFKGLKTTLALTTFVFNSINPDLSGPISIATISDGYDHGGFETADSIDDYLKDFKTSGSKTIADIIQKHQTSDNPITCIVYDAFLPWALDVAREFGLVATPFFTQPCAVNYVYYLSYINNGSLQLPIEELPFLELQDLPSFFSVSGSYPAYFEMVLQQFINFEKADFVLVNSFQELELHENELWSKACPVLTIGPTIPSIYLDQRIKSDTGYDLNLFESKDDSFCINWLDTRPQGSVVYVAFGSMAQLTNVQMEELASAVSNFSFLWVVRSSEEEKLPSGFLETVNKEKSLVLKWSPQLQVLSNKAIGCFLTHCGWNSTMEALTFGVPMVAMPQWTDQPMNAKYIQDVWKAGVRVKTEKESGIAKREEIEFSIKEVMEGERSKEMKKNVKKWRDLAVKSLNEGGSTDTNIDTFVSRV 5u6n B 2.001 BS05 SAL B 1 S15 H18 F113 Q134 M274 T365 S15 H18 F113 Q134 M274 T365 2.4.1.- 0005829,0008194,0009696,0010030,0016757,0018874,0035251,0046482,0052639,0052640,0052641,0080002,0090704 O22822 28425481 504 MEHKRGHVLAVPYPSQGHITPFRQFCKRLHFKGLKTTLALTTFVFNSINPDLSGPISIATISDGYDHGGFETADSIDDYLKDFKTSGSKTIADIIQKHQTSDNPITCIVYDAFLPWALDVAREFGLVATPFFTQPCAVNYVYYLSYINNGSLQLPIEELPFLELQDLPSFFSVSGSYPAYFEMVLQQFINFEKADFVLVNSFQELELHENELWSKACPVLTIGPTIPSIYLDQRIKSDTGYDLNLFESKDDSFCINWLDTRPQGSVVYVAFGSMAQLTNVQMEELASAVSNFSFLWVVRSSEEEKLPSGFLETVNKEKSLVLKWSPQLQVLSNKAIGCFLTHCGWNSTMEALTFGVPMVAMPQWTDQPMNAKYIQDVWKAGVRVKTEKESGIAKREEIEFSIKEVMEGERSKEMKKNVKKWRDLAVKSLNEGGSTDTNIDTFVSRVQS 5x80 A 2.4 BS01 SAL A 1 F38 V39 R42 F38 V39 R42 ? 0003677,0003700,0006355,0006950 Ka=24500M^-1 P9WME9 28743871 201 MGLADDAPLGYLLYRVGAVLRPEVSAALSPLGLTLPEFVCLRMLSQSPGLSSAELARHASVTPQAMNTVLRKLEDAGAVARPASVSSGRSLPATLTARGRALAKRAEAVVRAADARVLARLTAPQQREFKRMLEKLG 5x80 B 2.4 BS01 SAL A 1 P8 G10 P6 G8 ? 0003677,0003700,0006355,0006950 Ka=24500M^-1 P9WME9 28743871 201 LADDAPLGYLLYRVGAVLRPEVSAALSPLGLTLPEFVCLRMLSQSPGLSSAELARHASVTPQAMNTVLRKLEDAGAVARPASVSSGRSLPATLTARGRALAKRAEAVVRAADARVLARLTAPQQREFKRMLEKLG 5x80 B 2.4 BS02 SAL B 1 F38 R42 F36 R40 ? 0003677,0003700,0006355,0006950 Ka=24500M^-1 P9WME9 28743871 203 LADDAPLGYLLYRVGAVLRPEVSAALSPLGLTLPEFVCLRMLSQSPGLSSAELARHASVTPQAMNTVLRKLEDAGAVARPASVSSGRSLPATLTARGRALAKRAEAVVRAADARVLARLTAPQQREFKRMLEKLG 5yjs A 2.16 BS01 SAL A 1 F363 G382 Y395 R402 V404 G480 K490 F218 G237 Y250 R257 V259 G315 K325 ? 0046872 A0A452CSM5 30181145 603 NPYLFESAGFASAFRTGEGHLKILEKFTQRSELFRGIEKYRVAVLEFEPQSFMVPNHCDGEVIYVVAKGAGIISIAEQKAKYYFVLKKADVKRVPAGATIYFVNRDANQKLVVYVLVKSTNAPGEAQEYFSGGGQNPESFYRAFSSDILEKAFNTAADRLERLFGQQKQGPVIKASEEQIRAISQYASEPTAATGGEIRGPFNLLKGAPLFESRFGQFFEASPELFAQLRDLDVAVGYMNINQGGMVLPYYNTKSTRLVMVIEGNGRFEMACPHAGDVHYQKVRGNLNVGDLLVVPAAHPITFTATGGSNLRMVGFGINAQNNKKKFLAGKQNIWRNVDREAKELSFNMPGREVEEIFQKQDESYFVAGP 5yjs B 2.16 BS01 SAL B 1 F363 G382 Y395 N397 R402 G480 K490 F218 G237 Y250 N252 R257 G315 K325 ? 0046872 A0A452CSM5 30181145 601 NPYLFESAGFASAFRTGEGHLKILEKFTQRSELFRGIEKYRVAVLEFEPQSFMVPNHCDGEVIYVVAKGAGIISIAEQKAKYYFVLKKADVKRVPAGATIYFVNRDANQKLVVYVLVKSTNAPGEAQEYFSGGGQNPESFYRAFSSDILEKAFNTAADRLERLFGQQKQGPVIKASEEQIRAISQYASEPTAATGGEIRGPFNLLKGAPLFESRFGQFFEASPELFAQLRDLDVAVGYMNINQGGMVLPYYNTKSTRLVMVIEGNGRFEMACPHAGDVHYQKVRGNLNVGDLLVVPAAHPITFTATGGSNLRMVGFGINAQNNKKKFLAGKQNIWRNVDREAKELSFNMPGREVEEIFQKQDESYFVAGP 6jqx A 1.672 BS01 SAL A 1 Y27 H169 F195 D298 Y301 Y29 H171 F197 D300 Y303 4.1.1.91 0005737,0005829,0016787,0016831,0019748 P0CT50 34553918 401 GSMRGKVSLEEAFELPKFAAQTKEKAELYIAPNNRDRYFEEILNPCGNRLELSNKHGIGYTIYSIYSPGPQGWTERAECEEYARECNDYISGEIANHKDRMGAFAALSMHDPKQASEELTRCVKELGFLGALVNDVQHAGPEGETHIFYDQPEWDIFWQTCVDLDVPFYLHPEPPFGSYLRNQYEGRKYLIGPPVSFANGVSLHVLGMIVNGVFDRFPKLKVILGHLGEHIPGDFWRIEHWFEHCSRPLAKSRGDVFAEKPLLHYFRNNIWLTTSGNFSTETLKFCVEHVGAERILFSVDSPYEHIDVGCGWYDDNAKAIMEAVGGEKAYKDIGRDNAKKLFKLGKFYDSEA 6jqx B 1.672 BS01 SAL B 1 Y27 H169 P191 F195 H224 D298 Y301 Y29 H171 P193 F197 H226 D300 Y303 4.1.1.91 0005737,0005829,0016787,0016831,0019748 P0CT50 34553918 401 GSMRGKVSLEEAFELPKFAAQTKEKAELYIAPNNRDRYFEEILNPCGNRLELSNKHGIGYTIYSIYSPGPQGWTERAECEEYARECNDYISGEIANHKDRMGAFAALSMHDPKQASEELTRCVKELGFLGALVNDVQHAGPEGETHIFYDQPEWDIFWQTCVDLDVPFYLHPEPPFGSYLRNQYEGRKYLIGPPVSFANGVSLHVLGMIVNGVFDRFPKLKVILGHLGEHIPGDFWRIEHWFEHCSRPLAKSRGDVFAEKPLLHYFRNNIWLTTSGNFSTETLKFCVEHVGAERILFSVDSPYEHIDVGCGWYDDNAKAIMEAVGGEKAYKDIGRDNAKKLFKLGKFYDSE 6l4m A 3.302 BS01 SAL A 1 F228 G247 M249 Y260 N262 K267 V269 G351 K361 F211 G230 M232 Y243 N245 K250 V252 G301 K311 ? B0JEU3 31753489 501 NPYLFESQRFRSRFRASHGDFRILERFNQRSQLLKGIEKYRVAILELEPQSFVLPHHCDGEAIYVVVKGQGVINIAEQDNKNSFNLQKGDVIRLFAGSNVYLLNKDNNEKLFVYVLAKSVNAPGNLQEYFSAGGQNPESFYRAFSSDILESAFNNPRDKLERLFGQHKEGIIIKASEEQIRAISEHASRSTQGPFNLMKERPVFESRFGQFFEARPERYEQLRDLDAAVGFMNINQGGMVLPYYNTKSTKLVMVIEGNARFEMACYQKIRGNLNVGDVLVIPAGHPITFVATGNSNLRIVGFGVDAENNKKNFLAGKQNIWRNIDREAKELSFSMPGREVEEIFQRQDQSYFVAGPE 6ux1 A 1.36 BS02 SAL A 1 H94 L198 T200 H92 L195 T197 H64 H94 H96 E106 H119 T199 H62 H92 H94 E104 H117 T196 4.2.1.1,4.2.1.69 0002009,0004064,0004089,0005515,0005737,0005829,0005886,0006730,0008270,0015670,0016829,0018820,0032230,0032849,0038166,0043209,0044070,0045177,0046872,0046903,0051453,0070050,0070062,2001150,2001225 ic50=6.6mM Ki=7100nM, IC50=680000nM P00918 32244293 303 HHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 6ux1 A 1.36 BS03 SAL A 2 G6 Y7 G8 F231 E239 G4 Y5 G6 F228 E236 H64 H94 H96 E106 H119 T199 H62 H92 H94 E104 H117 T196 4.2.1.1,4.2.1.69 0002009,0004064,0004089,0005515,0005737,0005829,0005886,0006730,0008270,0015670,0016829,0018820,0032230,0032849,0038166,0043209,0044070,0045177,0046872,0046903,0051453,0070050,0070062,2001150,2001225 ic50=6.6mM Ki=7100nM, IC50=680000nM P00918 32244293 304 HHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 6ux1 A 1.36 BS04 SAL A 3 L164 D165 K225 K228 L161 D162 K222 K225 H64 H94 H96 E106 H119 T199 H62 H92 H94 E104 H117 T196 4.2.1.1,4.2.1.69 0002009,0004064,0004089,0005515,0005737,0005829,0005886,0006730,0008270,0015670,0016829,0018820,0032230,0032849,0038166,0043209,0044070,0045177,0046872,0046903,0051453,0070050,0070062,2001150,2001225 ic50=6.6mM Ki=7100nM, IC50=680000nM P00918 32244293 306 HHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 6wpg A 2.283 BS01 SAL A 1 R419 G492 C499 Y500 L503 R48 G99 C106 Y107 L110 ? 0009862,2000022,2000031 Q5ICL9 32788727 601 ENLYFQSMEPSKYRLCIDILEREIRRNPTCSHSMPEDLQMRLLYLEKRVGLAQLFFPAEANVAMDVANVEGTSECETPYVQTKRMLTRMKALMKTVETGRRYFPSCYEVLDKYMDQYMD 6wpg B 2.283 BS01 SAL B 1 R419 A423 A431 A434 V489 G492 Y500 L503 R42 A46 A54 A57 V83 G86 Y94 L97 ? 0009862,2000022,2000031 Q5ICL9 32788727 601 SMEPSKYRLCIDILEREIRRNPTCSHSMPEDLQMRLLYLEKRVGLAQLFFPAEANVAMDVANVTPYVQTKRMLTRMKALMKTVETGRRYFPSCYEVLDKYMDQYMD 8b1s A 1.6 BS01 SAL A 1 F157 L158 L213 R214 P290 F113 L114 L163 R164 P226 ? Q5XX06 39100314 401 DTPSNSMRPVADDNIDHTSHTPNGVASAFILEATVNVISGPKVLMKQIPIWLPLGIADQKTYSFDSTTAAIMLASYTITHFGKANNPLVRVNRLGQGIPDHPLRLLRMGNQAFLQEFVLPPVQLPQYFTFDLTALKLVTQPLPAATWTDTPSLRPGLSFHPKLRPVLLPGLTADKIQTIVNLMQDFKIVPIDPAKSIIGIEVPELLVHKLTGKKMNGQPIIPVLLPKYIPISPGDLTMVITPDY 8b2u A 1.8 BS01 SAL A 1 F157 L158 L213 R214 P290 F113 L114 L166 R167 P225 ? Q5XX06 39100314 401 DTPSNSMRPVADDNIDHTSHTPNGVASAFILEATVNVISGPKVLMKQIPIWLPLGIADQKTYSFDSTTAAIMLASYTITHFGKANNPLVRVNRLGQGIPDHPLRLLRMGNQAFLQEFVLPPVQLPQYFTFDLTALKLVTQPLPAATWTDTPSNLALRPGLSFHPKLRPVLLPGKIQTIVNLMQDFKIVPIDPAKSIIGIEVPELLVHKLTGKKMNGQPIIPVLLPKYPGDLTMVITPDYDDCHSPASC 8vae A 3.7 BS01 SAL A 1 N391 L453 N390 L452 0003677,0005504,0005507,0005515,0005576,0005615,0005634,0005737,0005783,0005788,0005794,0008289,0009267,0015643,0016209,0019825,0030170,0031093,0032991,0042802,0046872,0051087,0051902,0070062,0072562,0072732,0098869,0140272,1903981 P02768 38852682 601 AHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAA 8vae A 3.7 BS02 SAL A 2 L238 R257 L260 L237 R256 L259 0003677,0005504,0005507,0005515,0005576,0005615,0005634,0005737,0005783,0005788,0005794,0008289,0009267,0015643,0016209,0019825,0030170,0031093,0032991,0042802,0046872,0051087,0051902,0070062,0072562,0072732,0098869,0140272,1903981 P02768 38852682 602 AHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAA 8vae A 3.7 BS03 SAL A 3 I142 H146 L185 R186 I141 H145 L184 R185 0003677,0005504,0005507,0005515,0005576,0005615,0005634,0005737,0005783,0005788,0005794,0008289,0009267,0015643,0016209,0019825,0030170,0031093,0032991,0042802,0046872,0051087,0051902,0070062,0072562,0072732,0098869,0140272,1903981 P02768 38852682 603 AHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAA