1z3c A 2.2 BS01 SA8 A 1 K54 G72 D94 I95 D122 S123 Y124 Q140 F141 S142 Y145 K14 G32 D54 I55 D82 S83 Y84 Q100 F101 S102 Y105 2.1.1.56 0003723,0004482,0005634,0006370,0008168,0032259,0106005 ic50=100uM -logKd/Ki=4.00, IC50=100uM Q8SR66 15760890 299 SKTINIRNANNFIKACLIRLYTKRGDSVLDLGCGKGGDLLKYERAGIGEYYGVDIAEVSINDARVRARNMKRRFKVFFRAQDSYGRHMDLGKEFDVISSQFSFHYAFSTSESLDIAQRNIARHLRPGGYFIMTVPSRDVILERYKQGRMSNDFYKIELEKMEDVPMESVREYRFTLLDSVNNCIEYFVDFTRMVDGFKRLGLSLVERKGFIDFYEDEGRRNPELSKKMGLGCLTREESEVVGIYEVVVFRKL 2c4t A 2.3 BS01 SA8 A 1 D16 S23 W50 Y77 P78 T155 F156 D9 S16 W43 Y70 P71 T148 F149 2.5.1.63 0016740,0033846 Q70GK9 1299 RPIIAFMSDLGTTDDSVAQCKGLMYSICPDVTVVDVCHSMTPWDVEEGARYIVDLPRFFPEGTVFATTTYPATGTTTRSVAVRIKQAAKGGARGQWAGSGAGFERAEGSYIYIAPNNGLLTTVLEEHGYLEAYEVTSPKVIPEQPEPTFYSREMVAIPSAHLAAGFPLSEVGRPLEDHEIVRFNRPAVEQDGEALVGVVSAIDHPFGNVWTNIHRTDLEKAGIGYGARLRLTLDGVLPFEAPLTPTFADAGEIGNIAIYLNSRGYLSIARNAASLAYPYHLKEGMSARVEA 2c4t A 2.3 BS02 SA8 C 2 D210 F213 N215 W217 F254 S269 R270 R277 A279 D203 F206 N208 W210 F247 S262 R263 R270 A272 2.5.1.63 0016740,0033846 Q70GK9 1300 RPIIAFMSDLGTTDDSVAQCKGLMYSICPDVTVVDVCHSMTPWDVEEGARYIVDLPRFFPEGTVFATTTYPATGTTTRSVAVRIKQAAKGGARGQWAGSGAGFERAEGSYIYIAPNNGLLTTVLEEHGYLEAYEVTSPKVIPEQPEPTFYSREMVAIPSAHLAAGFPLSEVGRPLEDHEIVRFNRPAVEQDGEALVGVVSAIDHPFGNVWTNIHRTDLEKAGIGYGARLRLTLDGVLPFEAPLTPTFADAGEIGNIAIYLNSRGYLSIARNAASLAYPYHLKEGMSARVEA 2c4t B 2.3 BS01 SA8 A 1 D210 F213 N215 W217 F254 S269 R270 R277 A279 D203 F206 N208 W210 F247 S262 R263 R270 A272 2.5.1.63 0016740,0033846 Q70GK9 1299 RPIIAFMSDLGTTDDSVAQCKGLMYSICPDVTVVDVCHSMTPWDVEEGARYIVDLPRFFPEGTVFATTTYPATGTTTRSVAVRIKQAAKGGARGQWAGSGAGFERAEGSYIYIAPNNGLLTTVLEEHGYLEAYEVTSPKVIPEQPEPTFYSREMVAIPSAHLAAGFPLSEVGRPLEDHEIVRFNRPAVEQDGEALVGVVSAIDHPFGNVWTNIHRTDLEKAGIGYGARLRLTLDGVLPFEAPLTPTFADAGEIGNIAIYLNSRGYLSIARNAASLAYPYHLKEGMSARVEA 2c4t B 2.3 BS02 SA8 C 1 D16 L17 S23 W50 Y77 P78 T155 F156 S158 D9 L10 S16 W43 Y70 P71 T148 F149 S151 2.5.1.63 0016740,0033846 Q70GK9 1299 RPIIAFMSDLGTTDDSVAQCKGLMYSICPDVTVVDVCHSMTPWDVEEGARYIVDLPRFFPEGTVFATTTYPATGTTTRSVAVRIKQAAKGGARGQWAGSGAGFERAEGSYIYIAPNNGLLTTVLEEHGYLEAYEVTSPKVIPEQPEPTFYSREMVAIPSAHLAAGFPLSEVGRPLEDHEIVRFNRPAVEQDGEALVGVVSAIDHPFGNVWTNIHRTDLEKAGIGYGARLRLTLDGVLPFEAPLTPTFADAGEIGNIAIYLNSRGYLSIARNAASLAYPYHLKEGMSARVEA 2c4t C 2.3 BS01 SA8 C 1 D210 F213 N215 W217 F254 S269 R270 A279 D203 F206 N208 W210 F247 S262 R263 A272 2.5.1.63 0016740,0033846 Q70GK9 1299 RPIIAFMSDLGTTDDSVAQCKGLMYSICPDVTVVDVCHSMTPWDVEEGARYIVDLPRFFPEGTVFATTTYPATGTTTRSVAVRIKQAAKGGARGQWAGSGAGFERAEGSYIYIAPNNGLLTTVLEEHGYLEAYEVTSPKVIPEQPEPTFYSREMVAIPSAHLAAGFPLSEVGRPLEDHEIVRFNRPAVEQDGEALVGVVSAIDHPFGNVWTNIHRTDLEKAGIGYGARLRLTLDGVLPFEAPLTPTFADAGEIGNIAIYLNSRGYLSIARNAASLAYPYHLKEGMSARVEA 2c4t C 2.3 BS02 SA8 C 2 D16 L17 S23 W50 Y77 P78 T155 F156 D9 L10 S16 W43 Y70 P71 T148 F149 2.5.1.63 0016740,0033846 Q70GK9 1300 RPIIAFMSDLGTTDDSVAQCKGLMYSICPDVTVVDVCHSMTPWDVEEGARYIVDLPRFFPEGTVFATTTYPATGTTTRSVAVRIKQAAKGGARGQWAGSGAGFERAEGSYIYIAPNNGLLTTVLEEHGYLEAYEVTSPKVIPEQPEPTFYSREMVAIPSAHLAAGFPLSEVGRPLEDHEIVRFNRPAVEQDGEALVGVVSAIDHPFGNVWTNIHRTDLEKAGIGYGARLRLTLDGVLPFEAPLTPTFADAGEIGNIAIYLNSRGYLSIARNAASLAYPYHLKEGMSARVEA 2h2e A 2.6 BS01 SA8 A 1 E80 L82 S221 R222 L240 N242 H243 Y287 F302 E31 L33 S172 R173 L188 N190 H191 Y225 F240 Y287 Y225 2.1.1.127,2.1.1.259 0009507,0016279,0018022,0030785 -logKd/Ki=3.00, Kd>1000uM Q43088 16682405 800 LSPAVQTFWKWLQEEGVITAKTPVKASVVTEGLGLVALKDISRNDVILQVPKRLWINPDAVAASEIGRVCSELKPWLSVILFLIRERSREDSVWKHYFGILPQETDSTIYWSEEELQELQGSQLLKTTVSVKEYVKNECLKLEQEIILPNKRLFPDPVTLDDFFWAFGILRSRAFSRLNLVVVPMADLINHSAGVTTEDHAYEVYLFSLKSPLSVKAGEQVYIQYDLNKSNAELALDYGFIEPNENRHAYTLTLEISESDPFFDDKLDVAESNGFAQTAYFDIFYNRTLPPGLLPYLRLVALGGTDAFLLESLFRDTIWGHLELSVSRDNEELLCKAVREACKSALAGYHTTIEQDRELKEGNLDSRLAIAVGIREGEKMVLQQIDGIFEQKELELDQLEYYQERRLKDLGLCGENGDILENLY 2h2e B 2.6 BS01 SA8 B 1 L82 R222 N242 H243 Y287 F302 L34 R174 N194 H195 Y239 F254 Y287 Y239 2.1.1.127,2.1.1.259 0009507,0016279,0018022,0030785 Q43088 16682405 801 SLSPAVQTFWKWLQEEGVITAKTPVKASVVTEGLGLVALKDISRNDVILQVPKRLWINPDAVAASEIGRVCSELKPWLSVILFLIRERSREDSVWKHYFGILPQETDSTIYWSEEELQELQGSQLLKTTVSVKEYVKNECLKLEQEIILPNKRLFPDPVTLDDFFWAFGILRSRAFSRLRNENLVVVPMADLINHSAGVTTEDHAYEVKGAAGLFSWDYLFSLKSPLSVKAGEQVYIQYDLNKSNAELALDYGFIEPNENRHAYTLTLEISESDPFFDDKLDVAESNGFAQTAYFDIFYNRTLPPGLLPYLRLVALGGTDAFLLESLFRDTIWGHLELSVSRDNEELLCKAVREACKSALAGYHTTIEQDRELKEGNLDSRLAIAVGIREGEKMVLQQIDGIFEQKELELDQLEYYQERRLKDLGLCGENGDILENLYFQ 2h2e C 2.6 BS01 SA8 C 1 E80 G81 L82 S221 R222 L240 N242 H243 Y287 E31 G32 L33 S172 R173 L191 N193 H194 Y238 Y287 Y238 2.1.1.127,2.1.1.259 0009507,0016279,0018022,0030785 Q43088 16682405 802 LSPAVQTFWKWLQEEGVITAKTPVKASVVTEGLGLVALKDISRNDVILQVPKRLWINPDAVAASEIGRVCSELKPWLSVILFLIRERSREDSVWKHYFGILPQETDSTIYWSEEELQELQGSQLLKTTVSVKEYVKNECLKLEQEIILPNKRLFPDPVTLDDFFWAFGILRSRAFSRLRNENLVVVPMADLINHSAGVTTEDHAYEVKGAAGLFSWDYLFSLKSPLSVKAGEQVYIQYDLNKSNAELALDYGFIEPNENRHAYTLTLEISESDPFFDDKLDVAESNGFAQTAYFDIFYNRTLPPGLLPYLRLVALGGTDAFLLESLFRDTIWGHLELSVSRDNEELLCKAVREACKSALAGYHTTIEQDRELKEGNLDSRLAIAVGIREGEKMVLQQIDGIFEQKELELDQLEYYQERRLKDLGLCGENGDILENLYF 4gol D 2.57 BS01 SA8 D 1 A11 F35 D54 I55 S164 Y165 D181 P183 Y184 A9 F33 D52 I53 S162 Y163 D179 P181 Y182 2.1.1.72 0003676,0003677,0005515,0006260,0006261,0006298,0008168,0009007,0009307,0009411,0032259,0043565,1902328,1904047 P0AEE8 301 KNRAFLKWAGGKYPLLDDIKRHLPKGECLVEPFVGAGSVFLNTDFSRYILADINSDLISLYNIVKMRTDEYVQAARELFVPETNCAEVYYQFREEFNKSQDPFRRAVLFLYLNRYGYNGLCRYNLRGEFNVPFGRYKKPYFPEAELYHFAEKAQNAFFYCESYADSMARADDASVVYCDPPYAPLNSFTLEQQAHLAEIAEGLVERHIPVLISNHDTMLTREWYQRAKLHVVKVDELLALYKP 4gol E 2.57 BS01 SA8 E 1 A11 P34 F35 D54 I55 S164 Y165 D181 P182 P183 Y184 A9 P32 F33 D52 I53 S162 Y163 D179 P180 P181 Y182 2.1.1.72 0003676,0003677,0005515,0006260,0006261,0006298,0008168,0009007,0009307,0009411,0032259,0043565,1902328,1904047 P0AEE8 301 KNRAFLKWAGGKYPLLDDIKRHLPKGECLVEPFVGAGSVFLNTDFSRYILADINSDLISLYNIVKMRTDEYVQAARELFVPETNCAEVYYQFREEFNKSQDPFRRAVLFLYLNRYGYNGLCRYNLRGEFNVPFGRYKKPYFPEAELYHFAEKAQNAFFYCESYADSMARADDASVVYCDPPYAPLSFTLEQQAHLAEIAEGLVERHIPVLISNHDTMLTREWYQRAKLHVVKVKVDELLALYKP 4gol F 2.57 BS01 SA8 F 1 A11 F35 D54 I55 Y165 D181 P182 P183 Y184 A9 F33 D52 I53 Y163 D179 P180 P181 Y182 2.1.1.72 0003676,0003677,0005515,0006260,0006261,0006298,0008168,0009007,0009307,0009411,0032259,0043565,1902328,1904047 P0AEE8 301 KNRAFLKWAGGKYPLLDDIKRHLPKGECLVEPFVGAGSVFLNTDFSRYILADINSDLISLYNIVKMRTDEYVQAARELFVPETNCAEVYYQFREEFNKSQDPFRRAVLFLYLNRYGYNGLCRYNLRGEFNVPFGRYKKPYFPEAELYHFAEKAQNAFFYCESYADSMARADDASVVYCDPPYAPLNSFTLEQQAHLAEIAEGLVERHIPVLISNHDTMLTREWYQRAKLHVVKVVDELLALYKP 6wtf A 2.19 BS03 SA8 A 1 V74 H233 E236 S272 Y308 D335 L411 R412 V73 H220 E223 S259 Y295 D322 L398 R399 ? 0003824,0005829,0031419,0046872,0051536,0051539 E4N8S5 33462497 803 SRLVLLVNPNKVHPPIAPYALDVLTTALEDEGFEVEVLDLTFRRDDWKTCLHEYFAERSPMLVGVTVRNTDTVYAFEQRPFVGEHREIITEIRRLTDAPVVGGGIGFSTMPFALVEYFGIEYGVKGPGEKILCELATAISEGRDTAGIPGLIRNTERGAVRVPPAEPTGQFEPRVWQVDQLSVYRRRSGVPRKVDNLEYYRRGGLGSILTKNGCAYRCSHCVEPDAKGTRYGQRELASVVDEMESLAAQGILDQHTTDSEFNLSIAHAKNLLREIVRRRHADPDNPLNRLRLWVYCQPSPFDEEFADLLAAAGCRGVNVGSDHIRPELLSGWKVTEKGGTYYTFEDTERLVRLCRERGILTMVEALFGMPGETPETVRACVDAFMALDATVTGFSLGLRLFPYTPMGIEIAEQCAGVRTAPGLQSNTADGPIVLKPLRMCASPAEYERQFMFDEHGNFRLVCYFSPGLLPWHGAVADLWALIDPADHHRVMLPTVEGMSEHDNNYADNPFLTSLGGLGYTGAFWSHWRGREEIMRKAREAAA 6wtf B 2.19 BS03 SA8 B 1 V74 H233 E236 S272 E273 D335 L411 R412 V73 H218 E221 S257 E258 D320 L396 R397 ? 0003824,0005829,0031419,0046872,0051536,0051539 E4N8S5 33462497 803 SRLVLLVNPNKVHPPIAPYALDVLTTALEDEGFEVEVLDLTFRRDDWKTCLHEYFAERSPMLVGVTVRNTDTVYAFEQRPFVGEHREIITEIRRLTDAPVVGGGIGFSTMPFALVEYFGIEYGVKGPGEKILCELATAISEGRDTAGIPGLIRNTERGAVRVPPPTGQFEPRVWQVDQLSVYRRRSGVPRKVDNLEYYRRGGLGSILTKNGCAYRCSHCVEPDAKGTRYGQRELASVVDEMESLAAQGILDQHTTDSEFNLSIAHAKNLLREIVRRRHADPDNPLNRLRLWVYCQPSPFDEEFADLLAAAGCRGVNVGSDHIRPELLSGWKVTEKGGTYYTFEDTERLVRLCRERGILTMVEALFGMPGETPETVRACVDAFMALDATVTGFSLGLRLFPYTPMGIEIAEQCAGVRTAPGLQSNTADGPIVLKPLRMCASPAEYERQFMFDEHGNFRLVCYFSPGLLPERWHGAVADLWALIDPADHHRVMLPTVEGMSEHDNNYADNPFLTSLGGLGYTGAFWSHWRGREEIMRKARE