4ow0 A 2.1 BS01 S88 A 1 L163 G164 D165 P249 Y265 Y269 Q270 Y274 L160 G161 D162 P246 Y262 Y266 Q267 Y271 2.7.7.50,3.4.19.12,3.4.22.-,3.4.22.69 0006508,0008234 ic50=0.15uM -logKd/Ki=6.82, IC50=0.15uM IC50=150nM P0C6U8 24568342 902 KTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTI 4ow0 A 2.1 BS02 S88 B 1 P248 Y269 P245 Y266 2.7.7.50,3.4.19.12,3.4.22.-,3.4.22.69 0006508,0008234 ic50=0.15uM -logKd/Ki=6.82, IC50=0.15uM IC50=150nM P0C6U8 24568342 902 KTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTI 4ow0 B 2.1 BS01 S88 A 1 M209 P248 Y269 M153 P192 Y213 2.7.7.50,3.4.19.12,3.4.22.-,3.4.22.69 0006508,0008234 ic50=0.15uM IC50=150nM P0C6U8 24568342 902 FVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIK 4ow0 B 2.1 BS02 S88 B 1 G164 D165 P249 Y265 Y269 Y274 G108 D109 P193 Y209 Y213 Y218 2.7.7.50,3.4.19.12,3.4.22.-,3.4.22.69 0006508,0008234 ic50=0.15uM IC50=150nM P0C6U8 24568342 902 FVLPSDDTLRSEAFEYYHTLDESFLGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIK 7tzj A 2.66 BS01 S88 A 1 G163 P248 Y264 Y268 Q269 Y273 G161 P236 Y252 Y256 Q257 Y261 2.7.7.50,3.4.19.12,3.4.22.-,3.4.22.69 0006508,0008234 P0DTC1 35494659 401 RTIKVFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKIKPHNSHEGKTFYVLPNDDTLRVEAFEYYHTTDPSFLGRYMSALNHTKKWKYPQVNGLTSIKWADNNSYLATALLTLQQIELKFNPPALQDAYYRARAGEAANFCALILAYCNKTVGELGDVRETMSYLFQHANLDSCKRVLNVVTCGQQQTTLKGVEAVMYMGTLSYEQFKKGVQATKYLVQQESPFVMMSAPPAQYELKHGTFTCASEYTGNYQCGHYKHITSKETLYCIDGALLTKSSEYKGPITDVFYKENSYTT 7tzj B 2.66 BS01 S88 B 1 G163 D164 P248 Y264 Y268 Q269 Y273 G163 D164 P234 Y250 Y254 Q255 Y259 2.7.7.50,3.4.19.12,3.4.22.-,3.4.22.69 0006508,0008234 P0DTC1 35494659 401 EVRTIKVFTTVDNINLHTQVVDMSMTYGQQFGPTYLDGADVTKIKPHNSHEGKTFYVLPNDDTLRVEAFEYYHTTDPSFLGRYMSALNHTKKWKYPQVNGLTSIKWADNNSYLATALLTLQQIELKFNPPALQDAYYRARAGEAANFCALILAYCNKTVGELGDVRETMSYLFQHANLDSCKRVLNVVQQTTLKGVEAVMYMGTLSYEQFKKGVQATKYLVQQESPFVMMSAPPAQYELKHGTFTCASEYTGNYQCGHYKHITSKETLYCIDGALLTKSSEYKGPITDVFYKENSYTTTIK