2yg2 A 1.7 BS01 S1P A 1 W47 F71 R98 Y102 L111 R116 L123 L134 E136 Y147 W22 F46 R73 Y77 L86 R91 L98 L109 E111 Y122 ? O95445 21606363 301 CPSQLTTLGVDGEFPEVHLGQWYFIAGAAPTKEELATFDPVDNIVFNMAAGSAPMQLHLRATIRMKDGLCVPRKWIYHLTEGSTDLRTEGRPDMKTELFSSSCPGGIMLNETGQGYQRFLLYNRSPHPPEKCVEEFKSLTSCLDSKAFLLTPRNQEACELSN 2yg2 B 1.7 BS01 S1P B 1 W47 F71 R98 Y102 L111 R116 L134 E136 Y147 W16 F40 R64 Y68 L77 R82 L100 E102 Y113 ? O95445 21606363 301 LTTLGVEFPEVHLGQWYFIAGAAPTKEELATFDPVDNIVFNMAAPMQLHLRATIRMKDGLCVPRKWIYHLTEGSTDLRTEGRPDMKTELFSSSCPGGIMLNETGQGYQRFLLYNRSPHPPEKCVEEFKSLTSCLDSKAFLLTPRNQEACEL 3i9g H 1.9 BS01 S1P L 1 T33 I56 Y98 G99 S100 W100C T33 I57 Y102 G103 S104 W107 -logKd/Ki=8.96, Kd=1.1nM 19815502 401 EVQLVQSGAEVKKPGESLKISCQSFGYIFIDHTIHWMRQMPGQGLEWMGAISPRHDITKYNEMFRGQVTISADKSSSTAYLQWSSLKASDTAMYFCARGGFYGSTIWFDFWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPK 3i9g L 1.9 BS03 S1P L 1 D30 D32 E50 S91 D92 L94 D30 D32 E50 S91 D92 L94 Kd=1.1nM -logKd/Ki=8.96, Kd=1.1nM 19815502 401 ETTVTQSPSFLSASVGDRVTITCITTTDIDDDMNWFQQEPGKAPKLLISEGNILRPGVPSRFSSSGYGTDFTLTISKLQPEDFATYYCLQSDNLPFTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE 5ksi A 1.8 BS02 S1P A 1 F36 K99 L100 F36 K99 L100 ? 0004601,0005344,0005506,0005515,0005576,0005615,0005829,0005833,0015670,0015671,0016020,0019825,0020037,0030185,0031720,0031838,0042542,0042744,0043177,0046872,0070062,0071682,0072562,0098869 P69905 29127281 202 VLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVSTVLTSKYR 5ksi A 1.8 BS03 S1P A 2 T41 P44 K90 L91 T41 P44 K90 L91 ? 0004601,0005344,0005506,0005515,0005576,0005615,0005829,0005833,0015670,0015671,0016020,0019825,0020037,0030185,0031720,0031838,0042542,0042744,0043177,0046872,0070062,0071682,0072562,0098869 P69905 29127281 203 VLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVSTVLTSKYR 5ksi A 1.8 BS04 S1P D 1 T41 Y42 L91 T41 Y42 L91 ? 0004601,0005344,0005506,0005515,0005576,0005615,0005829,0005833,0015670,0015671,0016020,0019825,0020037,0030185,0031720,0031838,0042542,0042744,0043177,0046872,0070062,0071682,0072562,0098869 P69905 29127281 202 VLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVSTVLTSKYR 5ksi B 1.8 BS02 S1P C 2 R40 H97 R40 H97 ? 0004601,0005344,0005515,0005576,0005615,0005829,0005833,0008217,0015670,0015671,0019825,0020037,0030185,0030492,0031720,0031721,0031838,0042542,0042744,0043177,0045429,0046872,0070062,0070293,0070527,0071682,0072562,0097746,0098869,1904724,1904813 P68871 29127281 203 VHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGKEFTPPVQAAYQKVVAGVANALAHKYH 5ksi C 1.8 BS02 S1P C 1 F36 K99 L100 H103 F36 K99 L100 H103 ? 0004601,0005344,0005506,0005515,0005576,0005615,0005829,0005833,0015670,0015671,0016020,0019825,0020037,0030185,0031720,0031838,0042542,0042744,0043177,0046872,0070062,0071682,0072562,0098869 P69905 29127281 202 VLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVSTVLTSKYR 5ksi C 1.8 BS03 S1P C 2 T41 Y42 P44 K90 L91 R92 T41 Y42 P44 K90 L91 R92 ? 0004601,0005344,0005506,0005515,0005576,0005615,0005829,0005833,0015670,0015671,0016020,0019825,0020037,0030185,0031720,0031838,0042542,0042744,0043177,0046872,0070062,0071682,0072562,0098869 P69905 29127281 203 VLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVSTVLTSKYR 5ksi D 1.8 BS01 S1P A 2 R40 F41 L96 R40 F41 L96 ? 0004601,0005344,0005515,0005576,0005615,0005829,0005833,0008217,0015670,0015671,0019825,0020037,0030185,0030492,0031720,0031721,0031838,0042542,0042744,0043177,0045429,0046872,0070062,0070293,0070527,0071682,0072562,0097746,0098869,1904724,1904813 P68871 29127281 203 VHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGKEFTPPVQAAYQKVVAGVANALAHKYH 5ksi D 1.8 BS03 S1P D 1 R40 F41 L96 H97 R40 F41 L96 H97 ? 0004601,0005344,0005515,0005576,0005615,0005829,0005833,0008217,0015670,0015671,0019825,0020037,0030185,0030492,0031720,0031721,0031838,0042542,0042744,0043177,0045429,0046872,0070062,0070293,0070527,0071682,0072562,0097746,0098869,1904724,1904813 P68871 29127281 202 VHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGKEFTPPVQAAYQKVVAGVANALAHKYH 7c4s A 3.2 BS01 S1P A 1 Y22 E37 S99 G100 T103 R114 E115 F119 L122 L168 W256 I284 Y9 E24 S80 G81 T84 R95 E96 F100 L103 L149 W227 I255 ? 0003376,0004930,0005178,0005515,0005737,0005886,0006954,0007186,0007189,0007193,0007204,0007219,0008284,0008289,0009653,0016020,0019222,0032651,0038036,0098793,1903141 EC50=1.2nM, IC50=0.66nM Q99500 34108205 1001 GQETLREHYQYVGKLAGRLKEASEGSTLTTVLFLVICSFIVLENLMVLIAIWKRMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTVWFLREGSMFVALGASTCSLLAIAIERHLTMIKMRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCLHNLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYARIYFLVKSSERSMALLRTVVIVVSVFIACWSPLFILFLIDVACRVQACPILFKAQWFIVLAVLNSAMNPVIYTLASKEMRRAFFR 7c4s B 3.2 BS01 S1P B 1 Y22 N95 S99 G100 T103 R114 E115 F119 I203 W256 Y9 N76 S80 G81 T84 R95 E96 F100 I184 W225 ? 0003376,0004930,0005178,0005515,0005737,0005886,0006954,0007186,0007189,0007193,0007204,0007219,0008284,0008289,0009653,0016020,0019222,0032651,0038036,0098793,1903141 EC50=1.2nM, IC50=0.66nM Q99500 34108205 401 GQETLREHYQYVGKLAGRLKEASEGSTLTTVLFLVICSFIVLENLMVLIAIWKRMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTVWFLREGSMFVALGASTCSLLAIAIERHLTMIKMRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCLHNLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYARIYFLVKSSSMALLRTVVIVVSVFIACWSPLFILFLIDVACRVQACPILFKAQWFIVLAVLNSAMNPVIYTLASKEMRRAFFR 7ew3 R 3.1 BS01 S1P R 1 R31 S99 E115 L122 R16 S77 E93 L100 ? 0003376,0004930,0005178,0005515,0005737,0005886,0006954,0007186,0007189,0007193,0007204,0007219,0008284,0008289,0009653,0016020,0019222,0032651,0038036,0098793,1903141 EC50=1.2nM, IC50=0.66nM Q99500 34545189 401 ETLREHYQYVGKLAGRSTLTTVLFLVICSFIVLENLMVLIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTVWFLREGSMFVALGASTCSLLAIAIERHLTMIKMRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCLHNLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYARIYFLVKSSSRKVANHNNSERSMALLRTVVIVVSVFIACWSPLFILFLIDVACRVQACPILFKAQWFIVLAVLNSAMNPVIYTLASKEMRRAFFRL 7lhv A 2.75 BS01 S1P A 1 E478 L482 E409 L413 ? 0008271,0008272,0009507,0015293,0016020,0022857,0031969,0055085,1902358 Q9FY46 34294705 1001 MRLVDWIDTLFPCFRWIRTYRWSEYFKLDLMAGITVGIMLVPQAMSYAKLAGLPPIYGLYSSFVPVFVYAIFGSSRQLAIGPVALVSLLVSNALGGIADTNEELHIELAILLALLVGILECIMGLLRLGWLIRFISHSVISGFTSASAIVIGLSQIKYFLGYSIARSSKIVPIVESIIAGADKFQWPPFVMGSLILVILQVMKHVGKAKKELQFLRAAAPLTGIVLGTTIAKVFHPPSISLVGEIPQGLPTFSFPRSFDHAKTLLPTSALITGVAILESVGIAKALAAKNRYELDSNSELFGLGVANILGSLFSAYPATGSFSRSAVNNESEAKTGLSGLITGIIIGCSLLFLTPMFKYIPQCALAAIVISAVSGLVDYDEAIFLWRVDKRDFSLWTITSTITLFFGIEIGVLVGVGFSLAFVIHESANPHIAVLGRLPGTTVYRNIKQYPEAYTYNGIVIVRIDSPIYFANISYIKDRLREYEVAVDKYTNRGLEVDRINFVILEMSPVTHIDSSAVEALKELYQEYKTRDIQLAISNPNKDVHLTIARSGMVELVGKEWFFVRVHDAVQVCLQ 7lhv A 2.75 BS04 S1P A 2 G486 A490 G417 A421 ? 0008271,0008272,0009507,0015293,0016020,0022857,0031969,0055085,1902358 Q9FY46 34294705 1004 MRLVDWIDTLFPCFRWIRTYRWSEYFKLDLMAGITVGIMLVPQAMSYAKLAGLPPIYGLYSSFVPVFVYAIFGSSRQLAIGPVALVSLLVSNALGGIADTNEELHIELAILLALLVGILECIMGLLRLGWLIRFISHSVISGFTSASAIVIGLSQIKYFLGYSIARSSKIVPIVESIIAGADKFQWPPFVMGSLILVILQVMKHVGKAKKELQFLRAAAPLTGIVLGTTIAKVFHPPSISLVGEIPQGLPTFSFPRSFDHAKTLLPTSALITGVAILESVGIAKALAAKNRYELDSNSELFGLGVANILGSLFSAYPATGSFSRSAVNNESEAKTGLSGLITGIIIGCSLLFLTPMFKYIPQCALAAIVISAVSGLVDYDEAIFLWRVDKRDFSLWTITSTITLFFGIEIGVLVGVGFSLAFVIHESANPHIAVLGRLPGTTVYRNIKQYPEAYTYNGIVIVRIDSPIYFANISYIKDRLREYEVAVDKYTNRGLEVDRINFVILEMSPVTHIDSSAVEALKELYQEYKTRDIQLAISNPNKDVHLTIARSGMVELVGKEWFFVRVHDAVQVCLQ 7lhv A 2.75 BS05 S1P B 1 L197 L200 L128 L131 ? 0008271,0008272,0009507,0015293,0016020,0022857,0031969,0055085,1902358 Q9FY46 34294705 1001 MRLVDWIDTLFPCFRWIRTYRWSEYFKLDLMAGITVGIMLVPQAMSYAKLAGLPPIYGLYSSFVPVFVYAIFGSSRQLAIGPVALVSLLVSNALGGIADTNEELHIELAILLALLVGILECIMGLLRLGWLIRFISHSVISGFTSASAIVIGLSQIKYFLGYSIARSSKIVPIVESIIAGADKFQWPPFVMGSLILVILQVMKHVGKAKKELQFLRAAAPLTGIVLGTTIAKVFHPPSISLVGEIPQGLPTFSFPRSFDHAKTLLPTSALITGVAILESVGIAKALAAKNRYELDSNSELFGLGVANILGSLFSAYPATGSFSRSAVNNESEAKTGLSGLITGIIIGCSLLFLTPMFKYIPQCALAAIVISAVSGLVDYDEAIFLWRVDKRDFSLWTITSTITLFFGIEIGVLVGVGFSLAFVIHESANPHIAVLGRLPGTTVYRNIKQYPEAYTYNGIVIVRIDSPIYFANISYIKDRLREYEVAVDKYTNRGLEVDRINFVILEMSPVTHIDSSAVEALKELYQEYKTRDIQLAISNPNKDVHLTIARSGMVELVGKEWFFVRVHDAVQVCLQ 7lhv B 2.75 BS01 S1P A 2 L197 L200 L128 L131 ? 0008271,0008272,0009507,0015293,0016020,0022857,0031969,0055085,1902358 Q9FY46 34294705 1004 MRLVDWIDTLFPCFRWIRTYRWSEYFKLDLMAGITVGIMLVPQAMSYAKLAGLPPIYGLYSSFVPVFVYAIFGSSRQLAIGPVALVSLLVSNALGGIADTNEELHIELAILLALLVGILECIMGLLRLGWLIRFISHSVISGFTSASAIVIGLSQIKYFLGYSIARSSKIVPIVESIIAGADKFQWPPFVMGSLILVILQVMKHVGKAKKELQFLRAAAPLTGIVLGTTIAKVFHPPSISLVGEIPQGLPTFSFPRSFDHAKTLLPTSALITGVAILESVGIAKALAAKNRYELDSNSELFGLGVANILGSLFSAYPATGSFSRSAVNNESEAKTGLSGLITGIIIGCSLLFLTPMFKYIPQCALAAIVISAVSGLVDYDEAIFLWRVDKRDFSLWTITSTITLFFGIEIGVLVGVGFSLAFVIHESANPHIAVLGRLPGTTVYRNIKQYPEAYTYNGIVIVRIDSPIYFANISYIKDRLREYEVAVDKYTNRGLEVDRINFVILEMSPVTHIDSSAVEALKELYQEYKTRDIQLAISNPNKDVHLTIARSGMVELVGKEWFFVRVHDAVQVCLQ 7lhv B 2.75 BS02 S1P B 1 G486 A490 G417 A421 ? 0008271,0008272,0009507,0015293,0016020,0022857,0031969,0055085,1902358 Q9FY46 34294705 1001 MRLVDWIDTLFPCFRWIRTYRWSEYFKLDLMAGITVGIMLVPQAMSYAKLAGLPPIYGLYSSFVPVFVYAIFGSSRQLAIGPVALVSLLVSNALGGIADTNEELHIELAILLALLVGILECIMGLLRLGWLIRFISHSVISGFTSASAIVIGLSQIKYFLGYSIARSSKIVPIVESIIAGADKFQWPPFVMGSLILVILQVMKHVGKAKKELQFLRAAAPLTGIVLGTTIAKVFHPPSISLVGEIPQGLPTFSFPRSFDHAKTLLPTSALITGVAILESVGIAKALAAKNRYELDSNSELFGLGVANILGSLFSAYPATGSFSRSAVNNESEAKTGLSGLITGIIIGCSLLFLTPMFKYIPQCALAAIVISAVSGLVDYDEAIFLWRVDKRDFSLWTITSTITLFFGIEIGVLVGVGFSLAFVIHESANPHIAVLGRLPGTTVYRNIKQYPEAYTYNGIVIVRIDSPIYFANISYIKDRLREYEVAVDKYTNRGLEVDRINFVILEMSPVTHIDSSAVEALKELYQEYKTRDIQLAISNPNKDVHLTIARSGMVELVGKEWFFVRVHDAVQVCLQ 7lhv B 2.75 BS03 S1P B 2 E478 L482 E409 L413 ? 0008271,0008272,0009507,0015293,0016020,0022857,0031969,0055085,1902358 Q9FY46 34294705 1002 MRLVDWIDTLFPCFRWIRTYRWSEYFKLDLMAGITVGIMLVPQAMSYAKLAGLPPIYGLYSSFVPVFVYAIFGSSRQLAIGPVALVSLLVSNALGGIADTNEELHIELAILLALLVGILECIMGLLRLGWLIRFISHSVISGFTSASAIVIGLSQIKYFLGYSIARSSKIVPIVESIIAGADKFQWPPFVMGSLILVILQVMKHVGKAKKELQFLRAAAPLTGIVLGTTIAKVFHPPSISLVGEIPQGLPTFSFPRSFDHAKTLLPTSALITGVAILESVGIAKALAAKNRYELDSNSELFGLGVANILGSLFSAYPATGSFSRSAVNNESEAKTGLSGLITGIIIGCSLLFLTPMFKYIPQCALAAIVISAVSGLVDYDEAIFLWRVDKRDFSLWTITSTITLFFGIEIGVLVGVGFSLAFVIHESANPHIAVLGRLPGTTVYRNIKQYPEAYTYNGIVIVRIDSPIYFANISYIKDRLREYEVAVDKYTNRGLEVDRINFVILEMSPVTHIDSSAVEALKELYQEYKTRDIQLAISNPNKDVHLTIARSGMVELVGKEWFFVRVHDAVQVCLQ 7t6b R 3.19 BS01 S1P R 1 N89 F113 S117 F121 F274 N70 F94 S98 F102 F248 ? 0001664,0003376,0004930,0005178,0005515,0005737,0005886,0007186,0007189,0008284,0008289,0008528,0010800,0016020,0019222,0030036,0038036,0046847,0060079,0090394,0098793,0098794,0098978,0150052,1903142 O95136 35353559 401 NKVQEHYNYTKTSRQVASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSQTLALLKTVTIVLGVFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTW 7td3 R 3.0 BS01 S1P R 1 Y29 K34 N101 G106 T109 R120 E121 M124 F125 L297 Y12 K17 N78 G83 T86 R97 E98 M101 F102 L266 ? 0001525,0001664,0001955,0003245,0003376,0004930,0005515,0005654,0005737,0005768,0005886,0006935,0007155,0007186,0007189,0007193,0007200,0007420,0008283,0008284,0009897,0016020,0016477,0019222,0019226,0030032,0030036,0030155,0030182,0030335,0030500,0030595,0038036,0043231,0045121,0045124,0045446,0045944,0046625,0048661,0050927,0051497,0061384,0072678,0098793 P21453 35136060 401 DYVNYDIIVRHYNYTGKLNISIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFI 7vie F 2.86 BS01 S1P F 1 N101 S105 M124 F125 L128 L297 N66 S70 M89 F90 L93 L251 ? 0001525,0001664,0001955,0003245,0003376,0004930,0005515,0005654,0005737,0005768,0005886,0006935,0007155,0007186,0007189,0007193,0007200,0007420,0008283,0008284,0009897,0016020,0016477,0019222,0019226,0030032,0030036,0030155,0030182,0030335,0030500,0030595,0038036,0043231,0045121,0045124,0045446,0045944,0046625,0048661,0050927,0051497,0061384,0072678,0098793 P21453 35412894 401 DIIVRHYNYTGKTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIR 7wf7 A 3.4 BS01 S1P A 1 K34 R120 E121 G122 F125 L297 K12 R89 E90 G91 F94 L244 ? 0001525,0001664,0001955,0003245,0003376,0004930,0005515,0005654,0005737,0005768,0005886,0006935,0007155,0007186,0007189,0007193,0007200,0007420,0008283,0008284,0009897,0016020,0016477,0019222,0019226,0030032,0030036,0030155,0030182,0030335,0030500,0030595,0038036,0043231,0045121,0045124,0045446,0045944,0046625,0048661,0050927,0051497,0061384,0072678,0098793 IC50=1.40nM, EC50=4.3nM P21453 34937912 401 DIIVRHYNYTGKLNKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVWSLLAIAIERYITMLKMKLHFRLFLLISACWVISLILGGLPIMGWNCSALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFLALLKTVIIVLSVFIACWAPLFILLLLDVKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIR 7yub R 3.22 BS01 S1P R 1 Y116 F151 L332 E433 F437 Y24 F59 L229 E321 F325 ? 0001782,0002260,0002920,0003376,0005768,0005886,0006665,0006869,0007605,0010008,0016020,0022857,0030148,0043029,0046624,0048073,0048535,0055085,0060348,0072676,2000404 Q8IVW8 38123825 601 KPASLGRGRGAAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRVSPVLGMITGTLILILVPATKRGRTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVVQKTAAKDSLIFGAITCFTGFLGVVTGAGATRWCRLKTQRADPLVCAVGMLGSAIFICLIFVAAKSSIVGAYICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSFTSHLLGDAGSPYLIGFISDLIRQSTKDSPLWEFLSLGYALMLCPFVVVLGGMFFLATALFFVSDRARAEQQVNQLA 8ex4 A 2.93 BS01 S1P A 1 Y120 Y235 F236 P239 L332 V378 E433 F437 W440 Y22 Y137 F138 P141 L221 V256 E311 F315 W318 ? 0022857,0055085 Q8IVW8 37224812 601 EKRKAAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRVSPVLGMITGTLILILVPATKRGSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVVQKAKDSLIFGAITCFTGFLGVVTGAGATRWCRLKTQRADPLVCAVGMLGSAIFICLIFVAAKSSIVGAYICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSFTSHLLGDAGSPYLIGFISDLIRQSTKDSPLWEFLSLGYALMLCPFVVVLGGMFFLATALFFVSDRARAEQQVNQ 8ex6 A 3.54 BS01 S1P A 1 Y120 Y235 F236 T329 L332 G333 E433 F437 W440 Y22 Y137 F138 T217 L220 G221 E310 F314 W317 ? 0022857,0055085 Q8IVW8 37224812 601 EKRKAAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRVSPVLGMITGTLILILVPATKRSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVVQKAKDSLIFGAITCFTGFLGVVTGAGATRWCRLKTQRADPLVCAVGMLGSAIFICLIFVAAKSSIVGAYICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSFTSHLLGDAGSPYLIGFISDLIRQSTKDSPLWEFLSLGYALMLCPFVVVLGGMFFLATALFFVSDRARAEQQVNQ 8jhq A 3.6 BS01 S1P A 1 T518 L528 E629 F633 Q659 T227 L237 E338 F342 Q368 ? 0022857,0055085 Q8IVW8,Q9V2J8 38123824 801 ASLGRGRGAAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRVSPVLGMITGTLILILVPATKRGHADQLGDQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVVQKTAETCNSPPCGAKDSLIFGAITCFTGFLGVVTGAGATRWCRLKTQRADPLVCAVGMLGSAIFICLIFVAAKSSIVGAYICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSFTSHLLGDAGSPYLIGFISDLIRQSTKDSPLWEFLSLGYALMLCPFVVVLGGMFFLATALFFVSDRARAEQQVNQLA