4u5j A 2.26 BS01 RXT A 1 G276 V281 M341 A390 N391 L393 D404 G18 V23 M83 A132 N133 L135 D146 D386 R388 A390 N391 D404 F424 D128 R130 A132 N133 D146 F158 2.7.10.2 0004672,0004713,0005524,0006468 ic50=2.92uM -logKd/Ki=5.53, IC50=2.93uM P00523 25197973 601 AWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 4u5j B 2.26 BS01 RXT B 1 A293 K295 M341 A390 L393 A35 K37 M83 A132 L135 D386 R388 A390 N391 D404 F424 D128 R130 A132 N133 D146 F158 2.7.10.2 0004672,0004713,0005524,0006468 ic50=2.92uM P00523 25197973 601 AWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 6vgl A 1.9 BS01 RXT A 1 G858 A880 V911 M929 E930 L932 R980 N981 L983 G993 G31 A53 V84 M102 E103 L105 R153 N154 L156 G166 D976 R980 N981 D994 D149 R153 N154 D167 2.7.10.2 0004672,0004713,0005524,0006468 IC50=2.8nM, EC50=12nM, Kd=0.036000nM, Ki=0.100000nM O60674 33570945 1201 HHHHHENLYFQGDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6vgl B 1.9 BS01 RXT B 1 L855 G858 V863 A880 V911 M929 E930 L932 R980 N981 L983 G993 D994 L21 G24 V29 A46 V77 M95 E96 L98 R146 N147 L149 G159 D160 D976 R980 N981 D994 D142 R146 N147 D160 2.7.10.2 0004672,0004713,0005524,0006468 IC50=2.8nM, EC50=12nM, Kd=0.036000nM, Ki=0.100000nM O60674 33570945 1201 LYFQGDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6vgl C 1.9 BS01 RXT C 1 L855 G856 V863 A880 V911 M929 E930 L932 R980 N981 L983 G993 D994 L13 G14 V21 A38 V69 M87 E88 L90 R138 N139 L141 G151 D152 D976 R980 N981 D994 D134 R138 N139 D152 2.7.10.2 0004672,0004713,0005524,0006468 IC50=2.8nM, EC50=12nM, Kd=0.036000nM, Ki=0.100000nM O60674 33570945 1201 QFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMA 6vgl D 1.9 BS01 RXT D 1 L855 A880 V911 M929 E930 L932 R980 N981 L983 G993 D994 L13 A38 V69 M87 E88 L90 R138 N139 L141 G151 D152 D976 R980 N981 D994 D134 R138 N139 D152 2.7.10.2 0004672,0004713,0005524,0006468 IC50=2.8nM, EC50=12nM, Kd=0.036000nM, Ki=0.100000nM O60674 33570945 1201 QFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMA 6vnk A 2.0 BS01 RXT A 1 L855 G856 G858 A880 M929 E930 L932 R980 N981 L983 L21 G22 G24 A46 M94 E95 L97 R145 N146 L148 D976 R980 N981 D994 D141 R145 N146 D159 2.7.10.2 0004672,0004713,0005524,0006468 IC50=2.8nM, EC50=12nM, Kd=0.036000nM, Ki=0.100000nM O60674 33570945 1201 LYFQGDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6vnk B 2.0 BS01 RXT B 1 L855 A880 M929 E930 L932 R980 N981 L983 G993 L21 A46 M94 E95 L97 R145 N146 L148 G158 D976 R980 N981 D994 D141 R145 N146 D159 2.7.10.2 0004672,0004713,0005524,0006468 IC50=2.8nM, EC50=12nM, Kd=0.036000nM, Ki=0.100000nM O60674 33570945 1201 LYFQGDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG 6vnk C 2.0 BS01 RXT C 1 L855 G856 A880 M929 E930 L932 R980 N981 L983 G993 D994 L13 G14 A38 M87 E88 L90 R138 N139 L141 G151 D152 D976 R980 N981 D994 D134 R138 N139 D152 2.7.10.2 0004672,0004713,0005524,0006468 IC50=2.8nM, EC50=12nM, Kd=0.036000nM, Ki=0.100000nM O60674 33570945 1201 QFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMA 6vnk D 2.0 BS01 RXT D 1 L855 G856 G858 V863 A880 M929 E930 L932 R980 N981 L983 G993 D994 L13 G14 G16 V21 A38 M87 E88 L90 R138 N139 L141 G151 D152 D976 R980 N981 D994 D134 R138 N139 D152 2.7.10.2 0004672,0004713,0005524,0006468 IC50=2.8nM, EC50=12nM, Kd=0.036000nM, Ki=0.100000nM O60674 33570945 1201 QFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMA 6wtn A 1.83 BS01 RXT A 1 V863 A880 M929 E930 L932 R980 N981 L983 G993 D994 V21 A38 M85 E86 L88 R136 N137 L139 G149 D150 D976 R980 N981 D994 D132 R136 N137 D150 2.7.10.2 0004672,0004713,0005524,0006468 IC50=2.8nM, EC50=12nM, Kd=0.036000nM, Ki=0.100000nM O60674 34110416 1204 QFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAGGSG 7f3g A 2.1 BS01 RXT A 1 G397 V404 A417 M465 V468 E515 N516 L518 G22 V29 A42 M90 V93 E140 N141 L143 2.7.11.1 0004672,0005524,0006468 Kd=68nM O15075 34445192 701 SEEGFQIPATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVN 7f3g B 2.1 BS01 RXT B 1 V404 A417 K419 M465 E466 V468 E515 N516 L518 V22 A35 K37 M83 E84 V86 E133 N134 L136 2.7.11.1 0004672,0005524,0006468 Kd=68nM O15075 34445192 701 PATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVN