3rv9 A 2.14 BS01 RVD A 1 T361 Y385 L404 R405 A418 G419 K438 T331 Y355 L374 R375 A388 G389 K408 K205 E252 A269 E297 H334 T361 Y385 R405 G421 E434 K438 K191 E238 A255 E272 H304 T331 Y355 R375 G391 E404 K408 4.2.99.21,5.4.4.2,5.4.99.5 0000162,0000287,0004106,0005886,0008909,0009058,0009697,0010106,0016829,0016833,0016853,0019540,0043904,0046872,0052572 Ki=12uM -logKd/Ki=4.92, Ki=12uM P9WFX1 22607697 451 SSSIPMPAGVNPADLAAELAAVVTESVDEDYLLYECDGQWVLAAGVQAMVELDSDELRVIRDGVTRRQQWSGRPGAALGEAVDRLLLETDQAFGWVAFEFGVHRYGLQQRLAPHTPLARVFSPRTRIMVSEKEIRLFDAGIRHREAIDRLLATGVREVPQSRSVDVSDDPSGFRRRVAVAVDEIAAGRYHKVILSRCVEVPFAIDFPLTYRLGRRHNTPVRSFLLQLGGIRALGYSPELVTAVRADGVVITEPLAGTLARDDLESNSKEIVEHAISVRSSLEEITDIAEPGSAAVIDFMTVRQHLGSTIRARLDPSSDRMAALEALFPAVTASGIPKAAGVEAIFRLDECPRGLYSGAVVMLSADGGLDAALTLRAAYQVGGRTWLRAGAGIIEESEPEREFEETCEKLSTLTPYLVARQ 3rv9 B 2.14 BS01 RVD B 1 P251 L268 H334 T361 Y385 L404 R405 A418 G419 K438 P237 L254 H304 T331 Y355 L374 R375 A388 G389 K408 K205 E252 A269 E297 H334 T361 Y385 R405 G421 E434 K438 K191 E238 A255 E271 H304 T331 Y355 R375 G391 E404 K408 4.2.99.21,5.4.4.2,5.4.99.5 0000162,0000287,0004106,0005886,0008909,0009058,0009697,0010106,0016829,0016833,0016853,0019540,0043904,0046872,0052572 Ki=12uM P9WFX1 22607697 451 SSSIPMPAGVNPADLAAELAAVVTESVDEDYLLYECDGQWVLAAGVQAMVELDSDELRVIRDGVTRRQQWSGRPGAALGEAVDRLLLETDQAFGWVAFEFGVHRYGLQQRLAPHTPLARVFSPRTRIMVSEKEIRLFDAGIRHREAIDRLLATGVREVPQSRSVDVSDDPSGFRRRVAVAVDEIAAGRYHKVILSRCVEVPFAIDFPLTYRLGRRHNTPVRSFLLQLGGIRALGYSPELVTAVRADGVVITEPLAGTARDDLESNSKEIVEHAISVRSSLEEITDIAEPGSAAVIDFMTVRERHLGSTIRARLDPSSDRMAALEALFPAVTASGIPKAAGVEAIFRLDECPRGLYSGAVVMLSADGGLDAALTLRAAYQVGGRTWLRAGAGIIEESEPEREFEETCEKLSTLTPYLVARQ 3rv9 C 2.14 BS01 RVD C 1 E252 T361 Y385 L404 R405 A418 G419 K438 E238 T325 Y349 L368 R369 A382 G383 K402 K205 E252 E297 H334 T361 Y385 R405 G421 E434 K438 K191 E238 E266 H298 T325 Y349 R369 G385 E398 K402 4.2.99.21,5.4.4.2,5.4.99.5 0000162,0000287,0004106,0005886,0008909,0009058,0009697,0010106,0016829,0016833,0016853,0019540,0043904,0046872,0052572 Ki=12uM P9WFX1 22607697 451 SSSIPMPAGVNPADLAAELAAVVTESVDEDYLLYECDGQWVLAAGVQAMVELDSDELRVIRDGVTRRQQWSGRPGAALGEAVDRLLLETDQAFGWVAFEFGVHRYGLQQRLAPHTPLARVFSPRTRIMVSEKEIRLFDAGIRHREAIDRLLATGVREVPQSRSVDVSDDPSGFRRRVAVAVDEIAAGRYHKVILSRCVEVPFAIDFPLTYRLGRRHNTPVRSFLLQLGGIRALGYSPELVTAVRADGVVITEPLDDLESNSKEIVEHAISVRSSLEEITDIAEPGSAAVIDFMTVRQHLGSTIRARLDPSSDRMAALEALFPAVTASGIPKAAGVEAIFRLDECPRGLYSGAVVMLSADGGLDAALTLRAAYQVGGRTWLRAGAGIIEESEPEREFEETCEKLSTLTPYLVAR 3rv9 D 2.14 BS01 RVD D 1 P251 L268 T361 Y385 L404 R405 A418 G419 K438 P238 L255 T337 Y361 L380 R381 A394 G395 K414 K205 E252 A269 E297 H334 T361 Y385 R405 G421 E434 K438 K192 E239 A256 E277 H310 T337 Y361 R381 G397 E410 K414 4.2.99.21,5.4.4.2,5.4.99.5 0000162,0000287,0004106,0005886,0008909,0009058,0009697,0010106,0016829,0016833,0016853,0019540,0043904,0046872,0052572 Ki=12uM P9WFX1 22607697 451 ASSSIPMPAGVNPADLAAELAAVVTESVDEDYLLYECDGQWVLAAGVQAMVELDSDELRVIRDGVTRRQQWSGRPGAALGEAVDRLLLETDQAFGWVAFEFGVHRYGLQQRLAPHTPLARVFSPRTRIMVSEKEIRLFDAGIRHREAIDRLLATGVREVPQSRSVDVSDDPSGFRRRVAVAVDEIAAGRYHKVILSRCVEVPFAIDFPLTYRLGRRHNTPVRSFLLQLGGIRALGYSPELVTAVRADGVVITEPLAGTAIDRLARDDLESNSKEIVEHAISVRSSLEEITDIAEPGSAAVIDFMTVREQHLGSTIRARLDPSSDRMAALEALFPAVTASGIPKAAGVEAIFRLDECPRGLYSGAVVMLSADGGLDAALTLRAAYQVGGRTWLRAGAGIIEESEPEREFEETCEKLSTLTPYLVAR