3rv7 A 2.5 BS01 RVB A 1 P251 L268 T271 H334 T361 Y385 L404 R405 A418 G419 K438 P237 L254 T257 H301 T328 Y352 L371 R372 A385 G386 K405 K205 E252 A269 E297 H334 T361 Y385 R405 G421 E434 K438 K191 E238 A255 E270 H301 T328 Y352 R372 G388 E401 K405 4.2.99.21,5.4.4.2,5.4.99.5 0000162,0000287,0004106,0005886,0008909,0009058,0009697,0010106,0016829,0016833,0016853,0019540,0043904,0046872,0052572 Ki=14uM -logKd/Ki=4.85, Ki=14uM P9WFX1 22607697 451 SSSIPMPAGVNPADLAAELAAVVTESVDEDYLLYECDGQWVLAAGVQAMVELDSDELRVIRDGVTRRQQWSGRPGAALGEAVDRLLLETDQAFGWVAFEFGVHRYGLQQRLAPHTPLARVFSPRTRIMVSEKEIRLFDAGIRHREAIDRLLATGVREVPQSRSVDVSDDPSGFRRRVAVAVDEIAAGRYHKVILSRCVEVPFAIDFPLTYRLGRRHNTPVRSFLLQLGGIRALGYSPELVTAVRADGVVITEPLAGTRDDLESNSKEIVEHAISVRSSLEEITDIAEPGSAAVIDFMTVRHLGSTIRARLDPSSDRMAALEALFPAVTASGIPKAAGVEAIFRLDECPRGLYSGAVVMLSADGGLDAALTLRAAYQVGGRTWLRAGAGIIEESEPEREFEETCEKLSTLTPYLVAR 3rv7 B 2.5 BS01 RVB B 1 P251 H334 T361 L404 R405 A418 G419 K438 P238 H308 T335 L378 R379 A392 G393 K412 K205 E252 A269 E297 H334 T361 Y385 R405 G421 E434 K438 K192 E239 A256 E271 H308 T335 Y359 R379 G395 E408 K412 4.2.99.21,5.4.4.2,5.4.99.5 0000162,0000287,0004106,0005886,0008909,0009058,0009697,0010106,0016829,0016833,0016853,0019540,0043904,0046872,0052572 Ki=14uM P9WFX1 22607697 451 ASSSIPMPAGVNPADLAAELAAVVTESVDEDYLLYECDGQWVLAAGVQAMVELDSDELRVIRDGVTRRQQWSGRPGAALGEAVDRLLLETDQAFGWVAFEFGVHRYGLQQRLAPHTPLARVFSPRTRIMVSEKEIRLFDAGIRHREAIDRLLATGVREVPQSRSVDVSDDPSGFRRRVAVAVDEIAAGRYHKVILSRCVEVPFAIDFPLTYRLGRRHNTPVRSFLLQLGGIRALGYSPELVTAVRADGVVITEPLAGTRDDLESNSKEIVEHAISVRSSLEEITDIAEPGSAAVIDFMTVRERGSVQHLGSTIRARLDPSSDRMAALEALFPAVTASGIPKAAGVEAIFRLDECPRGLYSGAVVMLSADGGLDAALTLRAAYQVGGRTWLRAGAGIIEESEPEREFEETCEKLSTLTPYLVAR 3rv7 C 2.5 BS01 RVB C 1 T271 H334 Y385 L404 R405 A418 G419 K438 T257 H315 Y366 L385 R386 A399 G400 K419 K205 E252 A269 E297 H334 T361 Y385 R405 G421 E434 K438 K191 E238 A255 E283 H315 T342 Y366 R386 G402 E415 K419 4.2.99.21,5.4.4.2,5.4.99.5 0000162,0000287,0004106,0005886,0008909,0009058,0009697,0010106,0016829,0016833,0016853,0019540,0043904,0046872,0052572 Ki=14uM P9WFX1 22607697 451 SSSIPMPAGVNPADLAAELAAVVTESVDEDYLLYECDGQWVLAAGVQAMVELDSDELRVIRDGVTRRQQWSGRPGAALGEAVDRLLLETDQAFGWVAFEFGVHRYGLQQRLAPHTPLARVFSPRTRIMVSEKEIRLFDAGIRHREAIDRLLATGVREVPQSRSVDVSDDPSGFRRRVAVAVDEIAAGRYHKVILSRCVEVPFAIDFPLTYRLGRRHNTPVRSFLLQLGGIRALGYSPELVTAVRADGVVITEPLAGTRALGRGPAIDRLARDDLESNSKEIVEHAISVRSSLEEITDIAEPGSAAVIDFMTVRQHLGSTIRARLDPSSDRMAALEALFPAVTASGIPKAAGVEAIFRLDECPRGLYSGAVVMLSADGGLDAALTLRAAYQVGGRTWLRAGAGIIEESEPEREFEETCEKLSTLTPYLVARQ 3rv7 D 2.5 BS01 RVB D 1 P251 L268 T361 L404 R405 A418 G419 K438 P239 L256 T339 L382 R383 A396 G397 K416 K205 E252 A269 E297 H334 T361 Y385 R405 G421 E434 K438 K193 E240 A257 E275 H312 T339 Y363 R383 G399 E412 K416 4.2.99.21,5.4.4.2,5.4.99.5 0000162,0000287,0004106,0005886,0008909,0009058,0009697,0010106,0016829,0016833,0016853,0019540,0043904,0046872,0052572 Ki=14uM P9WFX1 22607697 451 TASSSIPMPAGVNPADLAAELAAVVTESVDEDYLLYECDGQWVLAAGVQAMVELDSDELRVIRDGVTRRQQWSGRPGAALGEAVDRLLLETDQAFGWVAFEFGVHRYGLQQRLAPHTPLARVFSPRTRIMVSEKEIRLFDAGIRHREAIDRLLATGVREVPQSRSVDVSDDPSGFRRRVAVAVDEIAAGRYHKVILSRCVEVPFAIDFPLTYRLGRRHNTPVRSFLLQLGGIRALGYSPELVTAVRADGVVITEPLAGTRLARDDLESNSKEIVEHAISVRSSLEEITDIAEPGSAAVIDFMTVRERGSVQHLGSTIRARLDPSSDRMAALEALFPAVTASGIPKAAGVEAIFRLDECPRGLYSGAVVMLSADGGLDAALTLRAAYQVGGRTWLRAGAGIIEESEPEREFEETCEKLSTLTPYLVARQ