1hxw A 1.8 BS01 RIT B 1 D25 G27 G48 G49 V82 I84 D25 G27 G48 G49 V82 I84 D25 T26 G27 D25 T26 G27 2.7.7.-,2.7.7.49,2.7.7.7,3.1.-.-,3.1.13.2,3.1.26.13,3.4.23.16 0004190,0006508 -logKd/Ki=10.82, Ki=15pM P12499 7708670 301 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF 1hxw B 1.8 BS01 RIT B 1 R8 D25 G27 D30 G49 I50 P81 V82 R8 D25 G27 D30 G49 I50 P81 V82 D25 T26 G27 D25 T26 G27 2.7.7.-,2.7.7.49,2.7.7.7,3.1.-.-,3.1.13.2,3.1.26.13,3.4.23.16 0004190,0006508 Ki=15pM -logKd/Ki=10.82, Ki=15pM P12499 7708670 301 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF 1n49 A 2.2 BS01 RIT B 1 N25 G27 D29 G48 G49 I50 P81 I84 N25 G27 D29 G48 G49 I50 P81 I84 N25 T26 G27 N25 T26 G27 2.7.7.-,2.7.7.49,2.7.7.7,3.1.-.-,3.1.13.2,3.1.26.13,3.4.23.16 0004190,0006508 P03369 12502847 301 PQITLWKRPLVTIRIGGQLKEALLNTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYDQIPVEICGHKAIGTVLVGPTPANIIGRNLLTQIGCTLNF 1n49 B 2.2 BS01 RIT B 1 R8 N25 G27 D30 G49 I50 P81 I84 R8 N25 G27 D30 G49 I50 P81 I84 N25 T26 G27 N25 T26 G27 2.7.7.-,2.7.7.49,2.7.7.7,3.1.-.-,3.1.13.2,3.1.26.13,3.4.23.16 0004190,0006508 P03369 12502847 301 PQITLWKRPLVTIRIGGQLKEALLNTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYDQIPVEICGHKAIGTVLVGPTPANIIGRNLLTQIGCTLNF 1n49 C 2.2 BS01 RIT D 1 R8 N25 D30 I47 G49 I50 P81 I84 R8 N25 D30 I47 G49 I50 P81 I84 N25 T26 G27 N25 T26 G27 2.7.7.-,2.7.7.49,2.7.7.7,3.1.-.-,3.1.13.2,3.1.26.13,3.4.23.16 0004190,0006508 P03369 12502847 401 PQITLWKRPLVTIRIGGQLKEALLNTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYDQIPVEICGHKAIGTVLVGPTPANIIGRNLLTQIGCTLNF 1n49 D 2.2 BS01 RIT D 1 N25 G27 D29 G48 G49 I50 P81 I84 N25 G27 D29 G48 G49 I50 P81 I84 N25 T26 G27 N25 T26 G27 2.7.7.-,2.7.7.49,2.7.7.7,3.1.-.-,3.1.13.2,3.1.26.13,3.4.23.16 0004190,0006508 P03369 12502847 401 PQITLWKRPLVTIRIGGQLKEALLNTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYDQIPVEICGHKAIGTVLVGPTPANIIGRNLLTQIGCTLNF 1rl8 A 2.0 BS01 RIT A 1 R8 D25 G27 D29 D30 G48 I50 P81 R8 D25 G27 D29 D30 G48 I50 P81 D25 T26 G27 D25 T26 G27 2.7.7.-,2.7.7.49,2.7.7.7,3.1.-.-,3.1.13.2,3.1.26.13,3.4.23.16 0004190,0006508 P03367 9001 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGAWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPANIIGRNLLTQIGCTLNF 1rl8 B 2.0 BS01 RIT A 1 D25 G27 A28 D29 G48 G49 I50 I84 D25 G27 A28 D29 G48 G49 I50 I84 D25 T26 G27 D25 T26 G27 2.7.7.-,2.7.7.49,2.7.7.7,3.1.-.-,3.1.13.2,3.1.26.13,3.4.23.16 0004190,0006508 P03367 9001 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGAWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPANIIGRNLLTQIGCTLNF 1sh9 A 2.5 BS01 RIT B 1 D25 G27 D29 I32 G48 G49 I50 P81 D25 G27 D29 I32 G48 G49 I50 P81 D25 T26 G27 D25 T26 G27 2.7.7.-,2.7.7.49,2.7.7.7,3.1.-.-,3.1.13.2,3.1.26.13,3.4.23.16 0004190,0006508 -logKd/Ki=6.03, Ki=932nM P03367 15379553 301 PQITLWQRPLVTIKIGGQLREALLDTGADDTIFEEISLPGRWKPKMIGGIGGFVKVRQYDQIPIEICGHKVIGTVLVGPTPANVIGRNLMTQIGCTLNF 1sh9 B 2.5 BS01 RIT B 1 D25 G27 D30 I47 I50 P81 D25 G27 D30 I47 I50 P81 D25 T26 G27 D25 T26 G27 2.7.7.-,2.7.7.49,2.7.7.7,3.1.-.-,3.1.13.2,3.1.26.13,3.4.23.16 0004190,0006508 Ki=932nM -logKd/Ki=6.03, Ki=932nM P03367 15379553 301 PQITLWQRPLVTIKIGGQLREALLDTGADDTIFEEISLPGRWKPKMIGGIGGFVKVRQYDQIPIEICGHKVIGTVLVGPTPANVIGRNLMTQIGCTLNF 2b60 A 2.2 BS01 RIT B 1 D25 G27 A28 D30 I47 P81 I84 D25 G27 A28 D30 I47 P81 I84 D25 T26 G27 D25 T26 G27 ? 0004190,0006508 Q7SMT3 100 PQITLWQRPLVTIKIGGQLREALLDTGADDTIFEEISLPGRWKPKMIGGIGGFIKVRQYDQIPIEICGHKVIGTVLVGPTPANIIGRNLMTQIGCTLNF 2b60 B 2.2 BS01 RIT B 1 D25 G27 D29 G48 G49 I50 A82 I84 D25 G27 D29 G48 G49 I50 A82 I84 D25 T26 G27 D25 T26 G27 ? 0004190,0006508 Q7SMT3 100 PQITLWQRPLVTIKIGGQLREALLDTGADDTIFEEISLPGRWKPKMIGGIGGFIKVRQYDQIPIEICGHKVIGTVLVGPTPANIIGRNLMTQIGCTLNF 3ndw A 1.14 BS01 RIT A 1 R8 D25 G27 A28 D29 G48 G49 I50 P81 V82 R8 D25 G27 A28 D29 G48 G49 I50 P81 V82 D25 T26 G27 D25 T26 G27 2.7.7.-,2.7.7.49,2.7.7.7,3.1.-.-,3.1.13.2,3.1.26.13,3.4.23.16 0004190,0006508 P03367 100 PQITLWKRPLVTIKIGGQLKEALLDTGADDTVIEEMSLPGRWKPKMIGGIGGFIKVRQYDQIIIEIAGHKAIGTVLVGPTPVNIIGRNLLTQIGATLNF 3ndw B 1.14 BS01 RIT A 1 D25 G27 A28 D29 G48 G49 I50 V82 I84 D25 G27 A28 D29 G48 G49 I50 V82 I84 D25 T26 G27 D25 T26 G27 2.7.7.-,2.7.7.49,2.7.7.7,3.1.-.-,3.1.13.2,3.1.26.13,3.4.23.16 0004190,0006508 P03367 100 PQITLWKRPLVTIKIGGQLKEALLDTGADDTVIEEMSLPGRWKPKMIGGIGGFIKVRQYDQIIIEIAGHKAIGTVLVGPTPVNIIGRNLLTQIGATLNF 3ndx A 1.03 BS01 RIT A 1 R8 D25 G27 A28 D29 G48 I50 P81 V82 R8 D25 G27 A28 D29 G48 I50 P81 V82 D25 T26 G27 D25 T26 G27 2.7.7.-,2.7.7.49,2.7.7.7,3.1.-.-,3.1.13.2,3.1.26.13,3.4.23.16 0004190,0006508 P03367 100 PQITLWKRPLVTIKIGGQLKEALLDTGADDTVIEEMSLPGRWKPKMIGGIGGFIKVRQYDQIIIEIAGHKAIGTVLVGPTPVNIIGRNLLTQIGATLNF 3ndx B 1.03 BS01 RIT A 1 D25 G27 A28 D29 G48 G49 I50 V82 I84 D25 G27 A28 D29 G48 G49 I50 V82 I84 D25 T26 G27 D25 T26 G27 2.7.7.-,2.7.7.49,2.7.7.7,3.1.-.-,3.1.13.2,3.1.26.13,3.4.23.16 0004190,0006508 P03367 100 PQITLWKRPLVTIKIGGQLKEALLDTGADDTVIEEMSLPGRWKPKMIGGIGGFIKVRQYDQIIIEIAGHKAIGTVLVGPTPVNIIGRNLLTQIGATLNF 3nxu A 2.0 BS02 RIT A 1 F57 F108 S119 L210 L211 F213 F241 I301 F304 A305 T309 I369 A370 R372 E374 G481 F29 F80 S91 L182 L183 F185 F213 I262 F265 A266 T270 I330 A331 R333 E335 G442 T309 F435 C442 T270 F396 C403 1.14.14.1,1.14.14.55,1.14.14.56,1.14.14.73 0002933,0004497,0005496,0005506,0005515,0005737,0005783,0005789,0006629,0006631,0006694,0006706,0006805,0008202,0008203,0008209,0008210,0008395,0008401,0009822,0016020,0016098,0016491,0016705,0016712,0019825,0019899,0020037,0030343,0034875,0036378,0042178,0042359,0042369,0042572,0042573,0042759,0043231,0046222,0046872,0050591,0050649,0062181,0062187,0062188,0062189,0070330,0070576,0070989,0101020,0101021,0102320 IC50=100nM, Ki=170nM P08684 20937904 600 SHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTRVDFLQLMIDSQNALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 3nxu B 2.0 BS02 RIT B 1 R105 F108 S119 L210 L211 F213 F241 I301 F304 A305 I369 A370 R372 L373 E374 G481 R77 F80 S91 L182 L183 F185 F213 I262 F265 A266 I330 A331 R333 L334 E335 G442 T309 F435 C442 T270 F396 C403 1.14.14.1,1.14.14.55,1.14.14.56,1.14.14.73 0002933,0004497,0005496,0005506,0005515,0005737,0005783,0005789,0006629,0006631,0006694,0006706,0006805,0008202,0008203,0008209,0008210,0008395,0008401,0009822,0016020,0016098,0016491,0016705,0016712,0019825,0019899,0020037,0030343,0034875,0036378,0042178,0042359,0042369,0042572,0042573,0042759,0043231,0046222,0046872,0050591,0050649,0062181,0062187,0062188,0062189,0070330,0070576,0070989,0101020,0101021,0102320 IC50=100nM, Ki=170nM P08684 20937904 600 SHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTRVDFLQLMIDSQNALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 3prs A 1.38 BS01 RIT A 1 D15 D33 D35 G37 S78 Y79 G80 D81 D119 F194 D219 G221 T222 T223 Y226 I304 D15 D33 D35 G37 S78 Y79 G80 D81 D119 F194 D219 G221 T222 T223 Y226 I304 D35 S38 D40 W42 Y79 D219 T222 D35 S38 D40 W42 Y79 D219 T222 3.4.23.22 0004190,0006508 -logKd/Ki=7.82, Ki=15nM P11838 22213702 1001 STGSATTTPIDSLDDAYITPVQIGTPAQTLNLDFDTGSSDLWVFSSETTASEVDGQTIYTPSKSTTAKLLSGATWSISYGDGSSSSGDVYTDTVSVGGLTVTGQAVESAKKVSSSFTEDSTIDGLLGLAFSTLNTVSPTQQKTFFDNAKASLDSPVFTADLGYHAPGTYNFGFIDTTAYTGSITYTAVSTKQGFWEWTSTGYAVGSGTFKSTSIDGIADTGTTLLYLPATVVSAYWAQVSGAKSSSSVGGYVFPCSATLPSFTFGVGSARIVIPGDYIDFGPISTGSSSCFGGIQSSAGIGINIFGDVALKAAFVVFNGATTPTLGFASK 3q70 A 1.4 BS01 RIT A 1 D32 G34 G83 Y84 G85 I119 N131 D218 G220 T221 T222 Y225 D32 G34 G83 Y84 G85 I119 N131 D218 G220 T221 T222 Y225 D32 S35 D37 W39 Y84 D218 T221 D32 S35 D37 W39 Y84 D218 T221 3.4.23.24 0004190,0005576,0006508,0046872 P0CS83 2001 QAVPVTLHNEQVTYAADITVGSNNQKLNVIVDTGSSDLWVPDVNVDCQVTYSDQTADFCKQKGTYDPSGSSASQDLNTPFKIGYGDGSSSQGTLYKDTVGFGGVSIKNQVLADVDSTSIDQGILGVGYKTNEAGGSYDNVPVTLKKQGVIAKNAYSLYLNSPDAATGQIIFGGVDNAKYSGSLIALPVTSDRELRISLGSVEVSGKTINTDNVDVLLDSGTTITYLQQDLADQIIKAFNGKLTQDSNGNSFYEVDCNLSGDVVFNFSKNAKISVPASEFAASLDKCQLLFDVNDANILGDNFLRSAYIVYDLDDNEISLAQVKYTSASSISALT 3tne A 2.4 BS01 RIT A 1 D32 G34 Y78 G79 D80 S82 V113 N125 D220 G222 T223 T224 Y227 I303 D32 G34 Y78 G79 D80 S82 V113 N125 D220 G222 T223 T224 Y227 I303 D32 S35 D37 W39 Y78 D220 T223 D32 S35 D37 W39 Y78 D220 T223 3.4.23.24 0004190,0005576,0006508 -logKd/Ki=5.72, Ki=1.9uM P32951 22146051 401 DSISLSLINEGPSYASKVSVGSNKQQQTVIIDTGSSDFWVVDSNAQCGKGVDCKSSGTFTPSSSSSYKNLGAAFTIRYGDGSTSQGTWGKDTVTINGVSITGQQIADVTQTSVDQGILGIGYTSNEAVYDTSGRQTTPNYDNVPVTLKKQGKIRTNAYSLYLNSPSAETGTIIFGGVDNAKYSGKLVAEQVTSSQALTISLASVNLKGSSFSFGDGALLDSGTTLTYFPSDFAAQLADKAGARLVQVARDQYLYFIDCNTDTSGTTVFNFGNGAKITVPNTEYVYQNGDGTCLWGIQPSDDTILGDNFLRHAYLLYNLDANTISIAQVKYTTDSSISAV 3tne B 2.4 BS01 RIT B 1 I30 D32 G34 I76 Y78 G79 D80 S82 D114 N125 D220 G222 T223 T224 I303 I30 D32 G34 I76 Y78 G79 D80 S82 D114 N125 D220 G222 T223 T224 I303 D32 S35 D37 W39 Y78 D220 T223 D32 S35 D37 W39 Y78 D220 T223 3.4.23.24 0004190,0005576,0006508 P32951 22146051 401 DSISLSLINEGPSYASKVSVGSNKQQQTVIIDTGSSDFWVVDSNAQCGKGVDCKSSGTFTPSSSSSYKNLGAAFTIRYGDGSTSQGTWGKDTVTINGVSITGQQIADVTQTSVDQGILGIGYTSNEAVYDTSGRQTTPNYDNVPVTLKKQGKIRTNAYSLYLNSPSAETGTIIFGGVDNAKYSGKLVAEQVTSSQALTISLASVNLKGSSFSFGDGALLDSGTTLTYFPSDFAAQLADKAGARLVQVARDQYLYFIDCNTDTSGTTVFNFGNGAKITVPNTEYVYQNGDGTCLWGIQPSDDTILGDNFLRHAYLLYNLDANTISIAQVKYTTDSSISAV 4eyr A 1.8 BS01 RIT B 1 L23 N25 G27 A28 D29 D30 T82 L23 N25 G27 A28 D29 D30 T82 N25 T26 G27 N25 T26 G27 3.1.26.13 0004190,0006508 -logKd/Ki=6.63, IC50=237nM Q000H7 23313846 301 PQITLWQRPIVTIKIGGQLKEALLNTGADDTVLEEVNLPGRWKPKLIGGIGGFVKVRQYDQVPIEICGHKVIGTVLVGPTPTNVIGRNLMTQIGCTLNF 4eyr B 1.8 BS01 RIT B 1 R8 N25 G27 A28 D29 D30 T82 R8 N25 G27 A28 D29 D30 T82 N25 T26 G27 N25 T26 G27 3.1.26.13 0004190,0006508 ic50=237nM -logKd/Ki=6.63, IC50=237nM Q000H7 23313846 301 PQITLWQRPIVTIKIGGQLKEALLNTGADDTVLEEVNLPGRWKPKLIGGIGGFVKVRQYDQVPIEICGHKVIGTVLVGPTPTNVIGRNLMTQIGCTLNF 4njv A 1.8 BS01 RIT A 1 D25 G27 A28 D29 G48 G49 I84 D25 G27 A28 D29 G48 G49 I84 D25 T26 G27 D25 T26 G27 ? 0004190,0006508 Q9J006 24752271 500 PQITLWQRPIVTIKVGGQLKEALLDTGADDTVLEDMELPGRWKPRMIGGIGGFVKVRQYDQIPIEICGHKVIGTVLVGPTPTNIIGRNLMTQLGFTLNF 4njv B 1.8 BS01 RIT A 1 R8 D25 G27 D30 G48 G49 I50 P81 T82 R8 D25 G27 D30 G48 G49 I50 P81 T82 D25 T26 G27 D25 T26 G27 ? 0004190,0006508 Q9J006 24752271 500 PQITLWQRPIVTIKVGGQLKEALLDTGADDTVLEDMELPGRWKPRMIGGIGGFVKVRQYDQIPIEICGHKVIGTVLVGPTPTNIIGRNLMTQLGFTLNF 4njv C 1.8 BS01 RIT D 1 D25 G27 D29 G48 G49 T82 I84 D25 G27 D29 G48 G49 T82 I84 D25 T26 G27 D25 T26 G27 ? 0004190,0006508 Q9J006 24752271 500 PQITLWQRPIVTIKVGGQLKEALLDTGADDTVLEDMELPGRWKPRMIGGIGGFVKVRQYDQIPIEICGHKVIGTVLVGPTPTNIIGRNLMTQLGFTLNF 4njv D 1.8 BS01 RIT D 1 R8 D25 G27 D30 G48 G49 I50 P81 T82 R8 D25 G27 D30 G48 G49 I50 P81 T82 D25 T26 G27 D25 T26 G27 ? 0004190,0006508 Q9J006 24752271 500 PQITLWQRPIVTIKVGGQLKEALLDTGADDTVLEDMELPGRWKPRMIGGIGGFVKVRQYDQIPIEICGHKVIGTVLVGPTPTNIIGRNLMTQLGFTLNF 5vc0 A 2.7 BS02 RIT A 1 F57 R106 F108 S119 L211 F213 I301 F304 I369 A370 R372 F30 R79 F81 S92 L184 F186 I268 F271 I336 A337 R339 T309 F435 C442 T276 F402 C409 1.14.14.1,1.14.14.55,1.14.14.56,1.14.14.73 0002933,0004497,0005496,0005506,0005515,0005737,0005783,0005789,0006629,0006631,0006694,0006706,0006805,0008202,0008203,0008209,0008210,0008395,0008401,0009822,0016020,0016098,0016491,0016705,0016712,0019825,0019899,0020037,0030343,0034875,0036378,0042178,0042359,0042369,0042572,0042573,0042759,0043231,0046222,0046872,0050591,0050649,0062181,0062187,0062188,0062189,0070330,0070576,0070989,0101020,0101021,0102320 IC50=100nM, Ki=170nM P08684 28590129 602 HSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 5vce A 2.2 BS02 RIT A 1 R105 R106 F108 S119 I120 R212 F213 F215 F241 I301 F304 A305 I369 A370 R80 R81 F83 S94 I95 R187 F188 F190 F216 I262 F265 A266 I330 A331 T309 F435 C442 T270 F396 C403 1.14.14.1,1.14.14.55,1.14.14.56,1.14.14.73 0002933,0004497,0005496,0005506,0005515,0005737,0005783,0005789,0006629,0006631,0006694,0006706,0006805,0008202,0008203,0008209,0008210,0008395,0008401,0009822,0016020,0016098,0016491,0016705,0016712,0019825,0019899,0020037,0030343,0034875,0036378,0042178,0042359,0042369,0042572,0042573,0042759,0043231,0046222,0046872,0050591,0050649,0062181,0062187,0062188,0062189,0070330,0070576,0070989,0101020,0101021,0102320 IC50=100nM, Ki=170nM P08684 28590129 602 GTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFAMFDMEMHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKEAYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNITVFPREVTNFLRKSVKRMKESRRVDFLQLMIDSQNKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVAKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPSKETQIPLKLSLGGLLQPEKPVVLKVESR 5veu A 2.91 BS02 RIT A 1 F210 F213 F215 F241 I301 F304 T309 A370 G480 F184 F187 F189 F215 I268 F271 T276 A337 G447 T309 F434 C441 T276 F401 C408 1.14.14.1 0002933,0004497,0005506,0005515,0005783,0005789,0006805,0008202,0008210,0008401,0009822,0016020,0016491,0016705,0016712,0019825,0020037,0042178,0042572,0042573,0043231,0046222,0046872,0050649,0070330,0070989,0101020 Ki=120nM P20815 29093019 602 TRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSR 5veu B 2.91 BS02 RIT B 1 R106 F210 F215 F241 I301 F304 A305 T309 A370 E374 G480 R80 F184 F189 F215 I268 F271 A272 T276 A337 E341 G443 T309 F434 C441 T276 F397 C404 1.14.14.1 0002933,0004497,0005506,0005515,0005783,0005789,0006805,0008202,0008210,0008401,0009822,0016020,0016491,0016705,0016712,0019825,0020037,0042178,0042572,0042573,0043231,0046222,0046872,0050649,0070330,0070989,0101020 Ki=120nM P20815 29093019 602 TRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSR 5veu H 2.91 BS02 RIT H 1 R105 F210 F213 F220 L240 I301 F304 A305 T309 E374 G480 L481 R79 F184 F187 F194 L214 I268 F271 A272 T276 E341 G444 L445 T309 F434 C441 T276 F398 C405 1.14.14.1 0002933,0004497,0005506,0005515,0005783,0005789,0006805,0008202,0008210,0008401,0009822,0016020,0016491,0016705,0016712,0019825,0020037,0042178,0042572,0042573,0043231,0046222,0046872,0050649,0070330,0070989,0101020 Ki=120nM P20815 29093019 602 TRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSR 6xcy A 2.05 BS01 RIT A 1 E13 D32 G34 T74 Y75 G76 T77 F111 Y189 D215 G217 T218 S219 M289 E13 D32 G34 T74 Y75 G76 T77 F111 Y189 D215 G217 T218 S219 M288 D32 S35 N37 W39 Y75 D215 T218 D32 S35 N37 W39 Y75 D215 T218 3.4.23.1 0004190,0006508 P00791 401 IGDEPLENYLDTEYFGTIGIGTPAQDFTVIFDTGSSNLWVPSVYCSSLACSDHNQFNPDDSSTFEATSQELSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPSISASGATPVFDNLWDQGLVSQDLFSVYLSSNDDSGSVVLLGGIDSSYYTGSLNWVPVSVEGYWQITLDSITMDGETIACSGGCQAIVDTGTSLLTGPTSAIANIQSDIGASENSDGEMVISCSSIDSLPDIVFTINGVQYPLSPSAYILQDDSCTSGFEGMDVPTSSGELWILGDVFIRQYYTVFDRANNKVGLAPVA 7ve0 A 1.9 BS01 RIT A 1 D36 G38 M77 N78 Y79 V80 S81 F113 L133 D216 G218 T219 S220 F246 F296 D34 G36 M75 N76 Y77 V78 S79 F111 L131 D214 G216 T217 S218 F244 F294 3.4.23.39 0004190,0006508 Q8I6V3 38304146 401 SSNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTAGCLTKHLYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYTASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPVHDKHTGFLTIGGIEERFYEGPLTYEKLNHDLYWQITLDAHVGNIMLEKANCIVDSGTSAITVPTDFLNKMLQNLDVIKVPFLPFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCMLNIIGLDFPVPTFILGDPFMRKYFTVFDYDNQSVGIALAKKNL 7ve0 B 1.9 BS01 RIT B 1 I16 D36 G38 M77 N78 Y79 V80 S81 F113 T116 L133 Y194 D216 G218 T219 S220 M288 F296 I13 D33 G35 M74 N75 Y76 V77 S78 F110 T113 L130 Y191 D213 G215 T216 S217 M285 F293 3.4.23.39 0004190,0006508 Q8I6V3 38304146 401 SNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTAGCLTKHLYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYTASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPVHDKHTGFLTIGGIEERFYEGPLTYEKLNHDLYWQITLDAHVGNIMLEKANCIVDSGTSAITVPTDFLNKMLQNLDVIKVPFLPFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCMLNIIGLDFPVPTFILGDPFMRKYFTVFDYDNQSVGIALAKK