2rku A 1.95 BS02 R78 A 1 R57 L59 C67 A80 V114 E131 C133 R136 F183 R21 L23 C31 A44 V78 E95 C97 R100 F147 D176 K178 G180 N181 D194 T214 D140 K142 G144 N145 D158 T178 2.7.11.21 0004672,0005524,0006468 ic50=8nM -logKd/Ki=8.30, IC50=5.0nM IC50=0.830000nM, Kd=0.190000nM, Ki=<1nM P53350 18005335 500 AKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPS 4i5m A 1.801 BS01 R78 A 1 K57 L59 K61 C67 A80 K82 L130 E131 Y132 C133 S134 R136 F183 K16 L18 K20 C26 A39 K41 L89 E90 Y91 C92 S93 R95 F142 D176 K178 G180 N181 D194 T214 D135 K137 G139 N140 D153 T162 2.7.11.21 0004672,0005524,0006468 ic50=0.0088uM -logKd/Ki=8.06, IC50=8.8nM IC50=14nM, Ki=<1nM, Kd=0.810000nM Q9NYY3 23794260 401 RIIVDPTTGKRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINESMELKVGDFGLAARLETPNYLSPEVLNKQGHGAESDIWALGCVMYTMLLGRPPFETTNLKETYRSIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFTQGFTPDRLSSSCCHTVPDF 4o74 A 1.45 BS01 R78 A 1 W81 P82 V87 L92 Y97 Y139 N140 I146 W40 P41 V46 L51 Y56 Y98 N99 I105 ? ic50=0.025uM -logKd/Ki=7.60, IC50=25nM IC50=25nM, Kd=37nM, Ki=56nM O60885 24568369 201 SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 4o74 B 1.45 BS01 R78 B 1 W81 P82 V87 L92 Y97 Y139 I146 W40 P41 V46 L51 Y56 Y98 I105 ? ic50=0.025uM IC50=25nM, Kd=37nM, Ki=56nM O60885 24568369 201 SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 4ogi A 1.73 BS01 R78 A 1 W81 P82 V87 L92 Y97 Y139 N140 I146 W40 P41 V46 L51 Y56 Y98 N99 I105 ? Kd=37nM -logKd/Ki=7.43, Kd=37nM IC50=25nM, Kd=37nM, Ki=56nM O60885 24584101 202 SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 4ogi B 1.73 BS01 R78 B 1 W81 P82 V87 L92 Y97 Y139 I146 W40 P41 V46 L51 Y56 Y98 I105 ? Kd=37nM IC50=25nM, Kd=37nM, Ki=56nM O60885 24584101 202 SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 4py6 A 2.5 BS01 R78 A 1 F1215 Y1216 V1221 D1224 N1226 I1227 F1277 N1278 I1287 F30 Y31 V36 D39 N41 I42 F92 N93 I102 ? Q8I240 1401 ENSNKRLLKQWEKILRDNVLKLLKNDNNAFYFKTPVLEDININDNIKEEYRIKIKKPMDYITISRNLSDGIYKEPIDFYHDMKLIYKNCIDFNPDIEENKYIIEAAKSSDMKFEFLWNKWKEKINNNFCDLN 4py6 B 2.5 BS01 R78 B 1 F1215 Y1216 V1221 N1226 I1227 F1277 N1278 N1284 I1287 F28 Y29 V34 N39 I40 F90 N91 N97 I100 ? Q8I240 1401 SNKRLLKQWEKILRDNVLKLLKNDNNAFYFKTPVLEDININDNIKEEYRIKIKKPMDYITISRNLSDGIYKEPIDFYHDMKLIYKNCIDFNPDIEENKYIIEAAKSSDMKFEFLWNKWKEKINNNFCDLNN 4py6 C 2.5 BS01 R78 C 1 F1215 Y1216 N1226 I1227 F1277 N1278 I1287 F26 Y27 N37 I38 F88 N89 I98 ? Q8I240 1401 KRLLKQWEKILRDNVLKLLKNDNNAFYFKTPVLEDININDNIKEEYRIKIKKPMDYITISRNLSDGIYKEPIDFYHDMKLIYKNCIDFNPDIEENKYIIEAAKSSDMKFEFLWNKWKEKINNNFCDL 4py6 D 2.5 BS01 R78 D 1 F1215 Y1216 V1221 D1224 N1226 I1227 F1277 N1278 I1287 F25 Y26 V31 D34 N36 I37 F87 N88 I97 ? Q8I240 1401 RLLKQWEKILRDNVLKLLKNDNNAFYFKTPVLEDININDNIKEEYRIKIKKPMDYITISRNLSDGIYKEPIDFYHDMKLIYKNCIDFNPDIEENKYIIEAAKSSDMKFEFLWNKWKEKINNNFCDLNN 5c8g A 1.95 BS01 R78 A 1 Y41 V46 V51 Y56 Y99 N100 Y37 V42 V47 Y52 Y95 N96 ? D0A8L1 201 LPKNKHVFHSDQRLAPEIRDLYDCLYKLYAEESASEYFREPVDALRVGAWNYYSVITEPMSLRTVLDYIVQGGRYSHVEQIMNDVELIWKNCERYNGAESHLAADARRCRAILEKHRERLAD 5c8g B 1.95 BS01 R78 B 1 Y41 V46 V51 Y56 Y99 L106 Y34 V39 V44 Y49 Y92 L99 ? D0A8L1 201 NKHVFHSDQRLAPEIRDLYDCLYKLYAEESASEYFREPVDALRVGAWNYYSVITEPMSLRTVLDYIVQGGRYSHVEQIMNDVELIWKNCERYNGAESHLAADARRCRAILEKHRERL 5tcm A 2.2 BS01 R78 A 1 H24 I25 Y86 Y93 H24 I25 Y86 Y93 ? A0A3Q8I8I6 201 YFQGYNEADVAALVRSLDRAEDHHIFAVDVLETYPYLAESYTKVCPRRCDLATAAQKALEGAYSYDLRLEGLKADIALMASNCVAYNGPTSAYAETAAKFERYALEQIDAFVLEHN 5tcm B 2.2 BS01 R78 B 1 H23 H24 I25 V30 Y86 Y93 H22 H23 I24 V29 Y85 Y92 ? A0A3Q8I8I6 201 FQGYNEADVAALVRSLDRAEDHHIFAVDVLETYPYLAESYTKVCPRRCDLATAAQKALEGAYSYDLRLEGLKADIALMASNCVAYNGPTSAYAETAAKFERYALEQIDAFVLEHN 5tcm C 2.2 BS01 R78 C 1 I25 V30 T33 Y86 Y93 I24 V29 T32 Y85 Y92 ? A0A3Q8I8I6 200 FQGYNEADVAALVRSLDRAEDHHIFAVDVLETYPYLAESYTKVCPRRCDLATAAQKALEGAYSYDLRLEGLKADIALMASNCVAYNGPTSAYAETAAKFERYALEQIDAFVLEHN 5vbq A 1.65 BS01 R78 A 1 P51 L61 Q62 L63 Y66 Y108 N109 I115 P27 L37 Q38 L39 Y42 Y84 N85 I91 ? IC50=1400nM Q58F21 34710325 201 GAASTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQMPQE 5vbq B 1.65 BS01 R78 B 1 P51 L61 L63 Y66 Y108 N109 I115 P27 L37 L39 Y42 Y84 N85 I91 ? IC50=1400nM Q58F21 34710325 201 GAASTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQMPQE 6bqq A 1.8 BS01 R78 A 1 I171 A192 V249 F267 E268 L269 V270 L319 I13 A34 V73 F91 E92 L93 V94 L143 D312 K314 N317 D330 T350 D136 K138 N141 D154 T174 2.7.11.17 0004672,0005524,0006468 Kd=23nM Q96RR4 501 SMQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTR 6cw0 A 1.38 BS01 R78 A 1 A25 V30 Y82 N83 A22 V27 Y79 N80 ? A3FQ86 201 EDYSREYSEVLLQLKELQDSEAFLEPVNWKKLGLDDYPDIVKNPMDLKTIGKKIKANFYTKAEQFWADIDLIWHNCQLYNHESSEVYQQSIRMQDAANNLRDML 6cw0 B 1.38 BS01 R78 B 1 A25 V30 Y82 N83 A21 V26 Y78 N79 ? A3FQ86 201 DYSREYSEVLLQLKELQDSEAFLEPVNWKKLGLDDYPDIVKNPMDLKTIGKKIKANFYTKAEQFWADIDLIWHNCQLYNHESSEVYQQSIRMQDAANNLRDML 6mf9 A 2.037 BS01 R78 A 1 V1871 V1876 I1880 Y1926 N1927 L1933 V33 V38 I42 Y88 N89 L95 ? 0000124,0046695 Q5CQH9 3000 PNITSYTEALDEFCIELQRIINSTKTLHHYSHVFWNRVSERIAPNYYNLVKRPMWLQLMINKCKKREYKSRKDFQDDLDLIVENCKIYNGVNHPLVSVATLIHSNVVKKIDEIQGIEKIEAYLSLK 6mf9 B 2.037 BS01 R78 B 1 V1871 I1880 Y1926 N1927 L1933 V34 I43 Y89 N90 L96 ? 0000124,0046695 Q5CQH9 3000 GPNITSYTEALDEFCIELQRIINSTKTLHHYSHVFWNRVSERIAPNYYNLVKRPMWLQLMINKCKKREYKSRKDFQDDLDLIVENCKIYNGVNHPLVSVATLIHSNVVKKIDEIQGIEKIEAYLSLK 7k0u A 2.52 BS01 R78 A 1 W1526 P1527 N1583 Y1589 W26 P27 N83 Y89 2.3.1.48,2.7.11.1 0004402,0005669,0006366,0016251,0017025 IC50=160nM, Kd=170nM P21675 35191694 1701 DDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNVCYQTLTEYDEHLTQLEKDICTAKEAALEE 7k0u B 2.52 BS01 R78 B 1 W1526 P1527 Y1589 W26 P27 Y89 2.3.1.48,2.7.11.1 0004402,0005669,0006366,0016251,0017025 IC50=160nM, Kd=170nM P21675 35191694 1702 DDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNVCYQTLTEYDEHLTQLEKDICT 7l9g A 1.36 BS01 R78 A 1 W370 P371 L381 L383 N429 H433 W25 P26 L36 L38 N84 H88 ? P25440 34710325 503 LSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPD 7l9l A 1.55 BS01 R78 A 1 W332 P333 V338 L343 L345 Y390 N391 H395 W29 P30 V35 L40 L42 Y87 N88 H92 ? Q15059 34710325 501 SMGKLSEHLRYCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLSTVKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMP 7lai A 1.85 BS01 R78 A 1 V103 Y155 N156 I162 V31 Y83 N84 I90 ? U3KQA6 34710325 201 GRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIP 7n7m A 2.6 BS01 R78 A 1 N124 F134 I143 T196 N198 V199 F200 I358 N91 F95 I104 T157 N159 V160 F161 I276 2.7.1.149 0001750,0001917,0005515,0005524,0005634,0005654,0005737,0005764,0005776,0005829,0005886,0006629,0010506,0016301,0016308,0016309,0016310,0035855,0042803,0042995,0046488,0046627,0046854,0052742,0061909,0090119,1902635,2000786 P48426 34001596 501 SDPLLSVLMWGVNHSINELSHVQIPVMLMPDDFKAYSKIKVDNHLFNKENMPSHFKFKEYCPMVFRNLRERFGIDDQDFQNSLTRSAPLPNDARFHTSYDKRYIIKTITSEDVAEMHNILKKYHQYIVECHGITLLPQFLGMYRLNVDGVEIYVIVTRNVFSHRLSVYRKYDLKGSTVAREASDKEKAKELPTLKDNDFINEGQKIYIDDNNKKVFLEKLKKDVEFLAQLKLMDYSLLVGIHDVERAGEFDPNIDVYGIKCHENSPRKEVYFMAIIDILTHVNPEQYSKRFLDFIGHIL