1iyl A 3.2 BS01 R64 A 1 Y107 D110 Y119 F176 Y225 H227 F240 F339 N392 C393 L451 Y40 D43 Y52 F109 Y158 H160 F173 F272 N325 C326 L384 N175 F176 L177 T211 L451 N108 F109 L110 T144 L384 2.3.1.97 0004379,0006499 -logKd/Ki=9.00, IC50=1nM IC50=1nM P30418 12401496 452 TPEDVPNDPLPLISDFEWSTLDIDDNLQLDELYKLLYDNYVEDIDATFRFKYSHEFFQWALKPPGWRKDWHVGVRVKSTGKLVAFIAATPVTFKLNKSNKVIDSVEINFLCIHKKLRNKRLAPVLIKEITRRVNKQNIWQALYTGGSILPTPLTTCRYQHRPINWSKLHDVGFSHLPPNQTKSSMVASYTLPNNPKLKGLRPMTGKDVSTVLSLLYKYQERFDIVQLFTEEEFKHWMLGHDENSDSNVVKSYVVEDENGIITDYFSYYLLPFTVLDNAQHDELGIAYLFYYASDSFEKPNYKKRLNELITDALITSKKFGVDVFNCLTCQDNTYFLKDCKFGSGDGFLNYYLFNYRTFPMDGGIDKKTKEVVEDQTSGIGVVLL 1iyl B 3.2 BS01 R64 B 1 Y107 F117 Y119 N175 F176 Y225 H227 F240 F339 I352 Y354 N392 L451 Y36 F46 Y48 N104 F105 Y154 H156 F169 F268 I281 Y283 N321 L380 N175 F176 L177 T211 L451 N104 F105 L106 T140 L380 2.3.1.97 0004379,0006499 IC50=1nM P30418 12401496 452 VPNDPLPLISDFEWSTLDIDDNLQLDELYKLLYDNYVEDIDATFRFKYSHEFFQWALKPPGWRKDWHVGVRVKSTGKLVAFIAATPVTFKLNKSNKVIDSVEINFLCIHKKLRNKRLAPVLIKEITRRVNKQNIWQALYTGGSILPTPLTTCRYQHRPINWSKLHDVGFSHLPPNQTKSSMVASYTLPNNPKLKGLRPMTGKDVSTVLSLLYKYQERFDIVQLFTEEEFKHWMLGHDENSDSNVVKSYVVEDENGIITDYFSYYLLPFTVLDNAQHDELGIAYLFYYASDSFEKPNYKKRLNELITDALITSKKFGVDVFNCLTCQDNTYFLKDCKFGSGDGFLNYYLFNYRTFPMDGGIDKKTKEVVEDQTSGIGVVLL 1iyl C 3.2 BS01 R64 C 1 Y107 I111 F117 Y119 F176 Y225 H227 F240 F339 N392 L394 L451 Y37 I41 F47 Y49 F106 Y155 H157 F170 F269 N322 L324 L381 N175 F176 L177 T211 L451 N105 F106 L107 T141 L381 2.3.1.97 0004379,0006499 IC50=1nM P30418 12401496 452 DVPNDPLPLISDFEWSTLDIDDNLQLDELYKLLYDNYVEDIDATFRFKYSHEFFQWALKPPGWRKDWHVGVRVKSTGKLVAFIAATPVTFKLNKSNKVIDSVEINFLCIHKKLRNKRLAPVLIKEITRRVNKQNIWQALYTGGSILPTPLTTCRYQHRPINWSKLHDVGFSHLPPNQTKSSMVASYTLPNNPKLKGLRPMTGKDVSTVLSLLYKYQERFDIVQLFTEEEFKHWMLGHDENSDSNVVKSYVVEDENGIITDYFSYYLLPFTVLDNAQHDELGIAYLFYYASDSFEKPNYKKRLNELITDALITSKKFGVDVFNCLTCQDNTYFLKDCKFGSGDGFLNYYLFNYRTFPMDGGIDKKTKEVVEDQTSGIGVVLL