1e8w A 2.5 BS01 QUE A 1 W812 K833 Y867 I879 E880 I881 V882 M953 I963 D964 W581 K602 Y636 I648 E649 I650 V651 M722 I732 D733 2.7.11.1,2.7.1.137,2.7.1.153,2.7.1.154 0016301,0046854 O02697 11090628 2095 ASEETLAFQRQLNALIGYDVTDVSNVHDDELEFTRRRLVTPRMAEVAGRDPKLYAMHPWVTSKPLPEYLLKKITNNCVFIVIHRSTTSQTIKVSADDTPGTILQSFFTKMDFVLRVCGRDEYLVGETPIKNFQWVRQCLKNGEEIHLVLDTPPDPALDEVRKEVSLWDCDRKFRVKIRGIDIPVLPRTADLTVFVEANIQYGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGQLLYYVNLLLIDHRFLLRHGEYVLHMWQLSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKDPKAYPKLFSSVKWGQQEIVAKTYQLLAKREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIDMLQKVTIDIKSLSAEKYDVSSQVISQLKQKLENLQNLNLPQSFRVPYDPGLKAGALVIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLSHWLKEKCPIEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMISETGNLFHIDFGNKERVPFVLTPDFLFVMGTSGKKTSLHFQKFQDVCVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKSEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGI 1gp6 A 1.75 BS01 QUE A 1 Y142 F144 K213 D234 V235 S236 F304 E306 Y141 F143 K212 D233 V234 S235 F303 E305 K213 V229 H232 D234 L287 H288 K212 V228 H231 D233 L286 H287 1.14.20.4 0007033,0009611,0009718,0009753,0009813,0010023,0031418,0046872,0050589,0051213 Q96323 11796114 380 VAVERVESLAKSGIISIPKEYIRPKEELESINDVFLEEKKEDGPQVPTIDLKNIESDDEKIRENCIEELKKASLDWGVMHLINHGIPADLMERVKKAGEEFFSLSVEEKEKYANDQATGKIQGYGSKLANNASGQLEWEDYFFHLAYPEEKRDLSIWPKTPSDYIEATSEYAKCLRLLATKVFKALSVGLGLEPDRLEKEVGGLEELLLQMKINYYPKCPQPELALGVEAHTDVSALTFILHNMVPGLQLFYEGKWVTAKCVPDSIVMHIGDTLEILSNGKYKSILHRGLVNKEKVRISWAVFCEPPKDKIVLKPLPEMVSVESPAKFPPRTFAQHIEHKLFGKEQEEL 1h1i A 1.75 BS02 QUE A 1 M51 V63 H66 H68 E73 F75 F136 P164 M49 V61 H64 H66 E71 F73 F134 P158 H66 H68 E73 H112 H64 H66 E71 H110 1.13.11.24 0008127,0046872,0051213 Q7SIC2 12486225 1358 SSLIVEDAPDHVRPYVIRHYSHARAVTVDTQLYRFYVTGPSSGYAFTLMGTNAPHSDALGVLPHIHQKHYENFYCNKGSFQLWAQSGNETQQTRVLSSGDYGSVPRNVTHTFQIQDPDTEMTGVIVPGGFEDLFYYLGTNATDTTHTPYIPSSSTTGPDSSTISTLQSFDVYAELSFTPRTDTVNGTAPANTVWHTGANALASTAGDPYFIANGWGPKYLNSQYGYQIVAPFVTATQAQDTNYTLSTISMSTTPSTVTVPTWSFPGACAFQVQEGRVVVQIGDYAATELGSGDVAFIPGGVEFKYYSEAYFSKVLFVSSGSDGLDQNLVNGGEEWSSVSFPADW 1h1i B 1.75 BS02 QUE B 1 M51 V63 H66 H68 E73 F75 L135 F136 L139 P164 V177 M49 V61 H64 H66 E71 F73 L133 F134 L137 P160 V173 H66 H68 E73 H112 H64 H66 E71 H110 1.13.11.24 0008127,0046872,0051213 Q7SIC2 12486225 1356 SSLIVEDAPDHVRPYVIRHYSHARAVTVDTQLYRFYVTGPSSGYAFTLMGTNAPHSDALGVLPHIHQKHYENFYCNKGSFQLWAQSGNETQQTRVLSSGDYGSVPRNVTHTFQIQDPDTEMTGVIVPGGFEDLFYYLGTNATDTTHTPYIPSSSSSTTGPDSSTISTLQSFDVYAELSFTPRTDTVNGTAPANTVWHTGANALASTAGDPYFIANGWGPKYLNSQYGYQIVAPFVTATQAQDTNYTLSTISMSTTPSTVTVPTWSFPGACAFQVQEGRVVVQIGDYAATELGSGDVAFIPGGVEFKYYSEAYFSKVLFVSSGSDGLDQNLVNGGEEWSSVSFPADW 1h1i C 1.75 BS02 QUE C 1 M51 V63 H66 H68 E73 F75 M123 L135 F136 P164 V177 M49 V61 H64 H66 E71 F73 M121 L133 F134 P157 V170 H66 H68 E73 H112 H64 H66 E71 H110 1.13.11.24 0008127,0046872,0051213 Q7SIC2 12486225 1358 SSLIVEDAPDHVRPYVIRHYSHARAVTVDTQLYRFYVTGPSSGYAFTLMGTNAPHSDALGVLPHIHQKHYENFYCNKGSFQLWAQSGNETQQTRVLSSGDYGSVPRNVTHTFQIQDPDTEMTGVIVPGGFEDLFYYLGTNATDTTHTPYIPSSTTGPDSSTISTLQSFDVYAELSFTPRTDTVNGTAPANTVWHTGANALASTAGDPYFIANGWGPKYLNSQYGYQIVAPFVTATQAQDTNYTLSTISMSTTPSTVTVPTWSFPGACAFQVQEGRVVVQIGDYAATELGSGDVAFIPGGVEFKYYSEAYFSKVLFVSSGSDGLDQNLVNGGEEWSSVSFPADW 1h1i D 1.75 BS02 QUE D 1 M51 V63 H66 H68 E73 F75 F136 P164 V177 M48 V60 H63 H65 E70 F72 F133 P157 V170 H66 H68 E73 H112 H63 H65 E70 H109 1.13.11.24 0008127,0046872,0051213 Q7SIC2 12486225 1357 SLIVEDAPDHVRPYVIRHYSHARAVTVDTQLYRFYVTGPSSGYAFTLMGTNAPHSDALGVLPHIHQKHYENFYCNKGSFQLWAQSGNETQQTRVLSSGDYGSVPRNVTHTFQIQDPDTEMTGVIVPGGFEDLFYYLGTNATDTTHTPYIPSSSTTGPDSSTISTLQSFDVYAELSFTPRTDTVNGTAPANTVWHTGANALASTAGDPYFIANGWGPKYLNSQYGYQIVAPFVTATQAQDTNYTLSTISMSTTPSTVTVPTWSFPGACAFQVQEGRVVVQIGDYAATELGSGDVAFIPGGVEFKYYSEAYFSKVLFVSSGSDGLDQNLVNGGEEWSSVSFPADW 2c9z A 2.1 BS02 QUE A 1 S18 H20 Q84 F121 H150 Q188 F200 F372 D374 S13 H15 Q75 F112 H141 Q179 F191 F354 D356 2.4.1.115,2.4.1.91 0008194,0009718,0016757,0033303,0033485,0047213,0047893 P51094 16482224 1458 TNPHVAVLAFPFSTHAAPLLAVVRRLAAAAPHAVFSFFSTSQSNASIFHTMQCNIKSYDISDGVPEGYVFAGRPQEDIELFTRAAPESFRQGMVMAVAETGRPVSCLVADAFIWFAADMAAEMGVAWLPFWTAGPNSLSTHVYIDEIREKIGVSGIQGREDELLNFIPGMSKVRFRDLQEGIVFGNLNSLFSRMLHRMGQVLPKATAVFINSFEELDDSLTNDLKSKLKTYLNIGPFNLITGCLQWLKERKPTSVVYISFGTVTTPPPAEVVALSEALEASRVPFIWSLRDKARVHLPEGFLEKTRGYGMVVPWAPQAEVLAHEAVGAFVTHCGWNSLWESVAGGVPLICRPFFGDQRLNGRMVEDVLEIGVRIEGGVFTKSGLMSCFDQILSQEKGKKLRENLRALRETADRAVGPKGSSTENFITLVDLVSKPKDV 2hck A 3.0 BS01 QUE A 1 L273 A293 T338 F340 M341 G344 L393 L190 A210 T255 F257 M258 G261 L310 D386 R388 A390 N391 D404 G406 P425 D303 R305 A307 N308 D321 G323 P332 2.7.10.2 0004672,0004713,0005524,0006468 P08631 9024658 1 EDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP 2hck B 3.0 BS02 QUE B 1 L273 V281 A293 T338 M341 G344 L393 L190 V198 A210 T255 M258 G261 L310 D386 R388 A390 N391 D404 G406 P425 D303 R305 A307 N308 D321 G323 P332 2.7.10.2 0004672,0004713,0005524,0006468 P08631 9024658 532 EDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP 2jj2 G 2.4 BS01 QUE G 1 A256 T259 K260 A151 T154 K155 3.6.1.34 0005515,0005739,0005743,0006754,0015986,0045259,0045261,0046933,1902600 P05631 17698806 1273 ATLKDITRRLKSIKNIQKITKSMKMVAAAKYARAERELKPARVYGVGSSDRGLCGAIHSSVAKQMIGVGDKIRSIKEVGRRPPTFGDIFNRFRSVISYKTEYSLANIIYYSLKESTTSEQSARMTAMDNASKNASEMIDKLTLTFNRTRQAVITKELIEIISGAAAL 2jj2 I 2.4 BS03 QUE N 1 R291 E292 R269 E270 K175 Q208 K209 R373 K153 Q186 K187 R351 3.6.1.34 0005515,0005524,0005737,0005739,0005743,0005886,0006754,0015986,0032559,0043531,0045259,0045261,0045267,0046034,0046933,1902600 P19483 17698806 1273 VDLEETGRVLSIGDGIARVHGLRNVQAEEMVEFSSGLKGMSLNLEPDNVGVVVFGNDKLIKEGDIVKRTGAIVDVPVGEELLGRVVDALGNAIDGKGPIGSKARRRVGLKAPGIIPRISVREPMQTGIKAVDSLVPIGRGQRELIIGDRQTGKTSIAIDTIINQKRFNDGTDEKKKLYCIYVAIGQKRSTVAQLVKRLTDADAMKYTIVVSATASDAAPLQYLAPYSGCSMGEYFRDNGKHALIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMNDAFGGGSLTALPVIETQAGDVSAYIPTNVISITDGQIFLETELFYKGIRPAINVGLSVSRVGSAAQTRAMKQVAGTMKLELAQYREVALDAATQQLLSRGVRLTELLKQGQYSPMAIEEQVAVIYAGVRGYLDKLEPSKITKFENAFLSHVISQHQALLSKIRTDGKISEESDAKLKEIVTNFLAGFE 2jj2 M 2.4 BS02 QUE N 1 A278 V279 A270 V271 K162 E188 R189 R356 K154 E180 R181 R348 7.1.2.2 0005515,0005524,0005737,0005739,0005743,0006754,0015986,0016887,0042776,0045259,0045261,0046034,0046933,0046961,1902600 P00829 17698806 1273 TTGRIVAVIGAVVDVQFDEGLPPILNALEVQGRETRLVLEVAQHLGESTVRTIAMDGTEGLVRGQKVLDSGAPIRIPVGPETLGRIMNVIGEPIDERGPIKTKQFAAIHAEAPEFVEMSVEQEILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESGVINLKDATSKVALVYGQMNEPPGARARVALTGLTVAEYFRDQEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGTMQERITTTKKGSITSVQAIYVPADDLTDPAPATTFAHLDATTVLSRAIAELGIYPAVDPLDSTSRIMDPNIVGSEHYDVARGVQKILQDYKSLQDIIAILGMDELSEEDKLTVSRARKIQRFLSQPFQVAEVFTGHLGKLVPLKETIKGFQQILAGEYDHLPEQAFYMVGPIEEAVAKADKLA 2jj2 N 2.4 BS01 QUE N 1 A256 T259 K260 A151 T154 K155 3.6.1.34 0005515,0005739,0005743,0006754,0015986,0045259,0045261,0046933,1902600 P05631 17698806 1273 ATLKDITRRLKSIKNIQKITKSMKMVAAAKYARAERELKPARVYGVGSSDRGLCGAIHSSVAKQMIGVGDKIRSIKEVGRRPPTFGDIFNRFRSVISYKTEYSLANIIYYSLKESTTSEQSARMTAMDNASKNASEMIDKLTLTFNRTRQAVITKELIEIISGAAAL 2o3p A 2.24 BS01 QUE A 1 L44 F49 A65 K67 E121 R122 P123 V126 L174 I185 D186 L12 F17 A33 K35 E89 R90 P91 V94 L142 I153 D154 D167 K169 N172 D186 L193 T204 D135 K137 N140 D154 L161 T172 2.7.11.1 0004672,0004674,0005515,0005524,0005634,0005654,0005730,0005737,0005829,0005886,0006338,0006468,0006915,0008134,0016310,0022898,0030145,0043024,0043066,0043433,0044024,0045824,0045893,0046777,0046872,0050821,0060045,0070561,0071346,0090336,0106310,1902033,1904263,1905062,1990748 ic50=1.1uM -logKd/Ki=5.96, IC50=1.1uM IC50=1100nM, Kd=25nM P11309 17218638 501 PLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHS 2uxh A 2.4 BS01 QUE A 1 L92 L93 N110 C137 I141 M167 V171 I175 L88 L89 N106 C133 I137 M163 V167 I171 ? 0000976,0001217,0003677,0003700,0006355,0032993,0045892 Q9AIU0 17466326 1211 TKEEAQETRAQIIEAAERAFYKRGVARTTLADIAELAGVTRGAIYWHFNNKAELVQALLDSLHETHDHLARASESEDEVDPLGCMRKLLLQVFNELVLDARTRRINEILHHKCEFTDDMCEIRQQRQSAVLDCHKGITLALANAVRRGQLPGELDAERAAVAMFAYVDGLIRRWLLLPDSVDLLGDVEKWVDTGLDMLRLSPALRK 2uxh B 2.4 BS01 QUE B 1 M89 L92 N110 I141 M167 D172 I175 M84 L87 N105 I136 M162 D167 I170 ? 0000976,0001217,0003677,0003700,0006355,0032993,0045892 Q9AIU0 17466326 1211 KEEAQETRAQIIEAAERAFYKRGVARTTLADIAELAGVTRGAIYWHFNNKAELVQALLDSLHETHDHLARASESEDEVDPLGCMRKLLLQVFNELVLDARTRRINEILHHKCEFTDDMCEIRQQRQSAVLDCHKGITLALANAVRRGQLPGELDAERAAVAMFAYVDGLIRRWLLLPDSVDLLGDVEKWVDTGLDMLRLSPALRK 3bpt A 1.5 BS01 QUE A 1 F56 L57 A59 G97 G98 I100 P168 I172 L350 F25 L26 A28 G66 G67 I69 P137 I141 L319 G98 P115 R119 G146 G149 E169 D177 G67 P84 R88 G115 G118 E138 D146 3.1.2.4 0003860,0005739,0005759,0006574,0009083,0016787 Q6NVY1 501 TDAAEEVLLGKKGCTGVITLNRPKFLNALTLNMIRQIYPQLKKWEQDPETFLIIIKGAGGKAFCAGGDIRVISEAEKAKQKIAPVFFREEYMLNNAVGSCQKPYVALIHGITMGGGVGLSVHGQFRVATEKCLFAMPETAIGLFPDVGGGYFLPRLQGKLGYFLALTGFRLKGRDVYRAGIATHFVDSEKLAMLEEDLLALKSPSKENIASVLENYHTESKIDRDKSFILEEHMDKINSCFSANTVEEIIENLQQDGSSFALEQLKVINKMSPTSLKITLRQLMEGSSKTLQEVLTMEYRLSQACMRGHDFHEGVRAVLIDKDQSPKWKPADLKEVTEEDLNNHFKSLGSSDLKFAENLYFQ 3bxx A 2.9 BS02 QUE A 1 S128 G130 Y163 F164 S123 G125 Y158 F159 1.1.1.219,1.1.1.234 0009718,0009813,0016491,0045552,0047890 P51110 18645237 342 ETVCVTGASGFIGSWLVMRLLERGYTVRATVRDPTNVKKVKHLLDLPKAETHLTLWKADLADEGSFDEAIKGCTGVFHVATPMDFESKDPENEVIKPTIEGMLGIMKSCAAAKTVRRLVFTSSAGTVNIQEHQLPVYDESCWSDMEFCRAKKMTAWMYFVSKTLAEQAAWKYAKENNIDFITIIPTLVVGPFIMSSMPPSLITALSPITGNEAHYSIIRQGQFVHLDDLCNAHIYLFENPKAEGRYICSSHDCIILDLAKMLREKYPEYNIPTEFKGVDENLKSVCFSSKKLTDLGFEFKYSLEDMFTGAVDTCRAKGLLPPSH 3bxx B 2.9 BS02 QUE B 1 S128 A129 G130 N133 L192 P204 S205 T208 I222 Q227 S123 A124 G125 N128 L187 P199 S200 T203 I217 Q222 1.1.1.219,1.1.1.234 0009718,0009813,0016491,0045552,0047890 P51110 18645237 341 ETVCVTGASGFIGSWLVMRLLERGYTVRATVRDPTNVKKVKHLLDLPKAETHLTLWKADLADEGSFDEAIKGCTGVFHVATPMDFESKDPENEVIKPTIEGMLGIMKSCAAAKTVRRLVFTSSAGTVNIQEHQLPVYDESCWSDMEFCRAKKMTAWMYFVSKTLAEQAAWKYAKENNIDFITIIPTLVVGPFIMSSMPPSLITALSPITGNEAHYSIIRQGQFVHLDDLCNAHIYLFENPKAEGRYICSSHDCIILDLAKMLREKYPEYNIPTEFKGVDENLKSVCFSSKKLTDLGFEFKYSLEDMFTGAVDTCRAKGLLPPSH 3bxx B 2.9 BS03 QUE B 2 S128 G130 Y163 P204 S123 G125 Y158 P199 1.1.1.219,1.1.1.234 0009718,0009813,0016491,0045552,0047890 P51110 18645237 342 ETVCVTGASGFIGSWLVMRLLERGYTVRATVRDPTNVKKVKHLLDLPKAETHLTLWKADLADEGSFDEAIKGCTGVFHVATPMDFESKDPENEVIKPTIEGMLGIMKSCAAAKTVRRLVFTSSAGTVNIQEHQLPVYDESCWSDMEFCRAKKMTAWMYFVSKTLAEQAAWKYAKENNIDFITIIPTLVVGPFIMSSMPPSLITALSPITGNEAHYSIIRQGQFVHLDDLCNAHIYLFENPKAEGRYICSSHDCIILDLAKMLREKYPEYNIPTEFKGVDENLKSVCFSSKKLTDLGFEFKYSLEDMFTGAVDTCRAKGLLPPSH 3bxx C 2.9 BS02 QUE C 1 S128 A129 N133 L192 P204 S205 T208 I222 Q227 S123 A124 N128 L187 P199 S200 T203 I217 Q222 1.1.1.219,1.1.1.234 0009718,0009813,0016491,0045552,0047890 P51110 18645237 341 ETVCVTGASGFIGSWLVMRLLERGYTVRATVRDPTNVKKVKHLLDLPKAETHLTLWKADLADEGSFDEAIKGCTGVFHVATPMDFESKDPENEVIKPTIEGMLGIMKSCAAAKTVRRLVFTSSAGTVNIQEHQLPVYDESCWSDMEFCRAKKMTAWMYFVSKTLAEQAAWKYAKENNIDFITIIPTLVVGPFIMSSMPPSLITALSPITGNEAHYSIIRQGQFVHLDDLCNAHIYLFENPKAEGRYICSSHDCIILDLAKMLREKYPEYNIPTEFKGVDENLKSVCFSSKKLTDLGFEFKYSLEDMFTGAVDTCRAKGLLPPSH 3bxx C 2.9 BS03 QUE C 2 S128 G130 Y163 F164 P204 S123 G125 Y158 F159 P199 1.1.1.219,1.1.1.234 0009718,0009813,0016491,0045552,0047890 P51110 18645237 342 ETVCVTGASGFIGSWLVMRLLERGYTVRATVRDPTNVKKVKHLLDLPKAETHLTLWKADLADEGSFDEAIKGCTGVFHVATPMDFESKDPENEVIKPTIEGMLGIMKSCAAAKTVRRLVFTSSAGTVNIQEHQLPVYDESCWSDMEFCRAKKMTAWMYFVSKTLAEQAAWKYAKENNIDFITIIPTLVVGPFIMSSMPPSLITALSPITGNEAHYSIIRQGQFVHLDDLCNAHIYLFENPKAEGRYICSSHDCIILDLAKMLREKYPEYNIPTEFKGVDENLKSVCFSSKKLTDLGFEFKYSLEDMFTGAVDTCRAKGLLPPSH 3bxx D 2.9 BS02 QUE D 1 S128 A129 N133 L192 T208 I222 S123 A124 N128 L187 T203 I217 1.1.1.219,1.1.1.234 0009718,0009813,0016491,0045552,0047890 P51110 18645237 341 ETVCVTGASGFIGSWLVMRLLERGYTVRATVRDPTNVKKVKHLLDLPKAETHLTLWKADLADEGSFDEAIKGCTGVFHVATPMDFESKDPENEVIKPTIEGMLGIMKSCAAAKTVRRLVFTSSAGTVNIQEHQLPVYDESCWSDMEFCRAKKMTAWMYFVSKTLAEQAAWKYAKENNIDFITIIPTLVVGPFIMSSMPPSLITALSPITGNEAHYSIIRQGQFVHLDDLCNAHIYLFENPKAEGRYICSSHDCIILDLAKMLREKYPEYNIPTEFKGVDENLKSVCFSSKKLTDLGFEFKYSLEDMFTGAVDTCRAKGLLPPSH 3bxx D 2.9 BS03 QUE D 2 S128 G130 Y163 F164 S123 G125 Y158 F159 1.1.1.219,1.1.1.234 0009718,0009813,0016491,0045552,0047890 P51110 18645237 342 ETVCVTGASGFIGSWLVMRLLERGYTVRATVRDPTNVKKVKHLLDLPKAETHLTLWKADLADEGSFDEAIKGCTGVFHVATPMDFESKDPENEVIKPTIEGMLGIMKSCAAAKTVRRLVFTSSAGTVNIQEHQLPVYDESCWSDMEFCRAKKMTAWMYFVSKTLAEQAAWKYAKENNIDFITIIPTLVVGPFIMSSMPPSLITALSPITGNEAHYSIIRQGQFVHLDDLCNAHIYLFENPKAEGRYICSSHDCIILDLAKMLREKYPEYNIPTEFKGVDENLKSVCFSSKKLTDLGFEFKYSLEDMFTGAVDTCRAKGLLPPSH 3bxx F 2.9 BS02 QUE F 1 S128 A129 G130 N133 L192 P204 S205 T208 Q227 S123 A124 G125 N128 L187 P199 S200 T203 Q222 1.1.1.219,1.1.1.234 0009718,0009813,0016491,0045552,0047890 P51110 18645237 341 ETVCVTGASGFIGSWLVMRLLERGYTVRATVRDPTNVKKVKHLLDLPKAETHLTLWKADLADEGSFDEAIKGCTGVFHVATPMDFESKDPENEVIKPTIEGMLGIMKSCAAAKTVRRLVFTSSAGTVNIQEHQLPVYDESCWSDMEFCRAKKMTAWMYFVSKTLAEQAAWKYAKENNIDFITIIPTLVVGPFIMSSMPPSLITALSPITGNEAHYSIIRQGQFVHLDDLCNAHIYLFENPKAEGRYICSSHDCIILDLAKMLREKYPEYNIPTEFKGVDENLKSVCFSSKKLTDLGFEFKYSLEDMFTGAVDTCRAKGLLPPSH 3bxx F 2.9 BS03 QUE F 2 S128 G130 Y163 F164 S123 G125 Y158 F159 1.1.1.219,1.1.1.234 0009718,0009813,0016491,0045552,0047890 P51110 18645237 342 ETVCVTGASGFIGSWLVMRLLERGYTVRATVRDPTNVKKVKHLLDLPKAETHLTLWKADLADEGSFDEAIKGCTGVFHVATPMDFESKDPENEVIKPTIEGMLGIMKSCAAAKTVRRLVFTSSAGTVNIQEHQLPVYDESCWSDMEFCRAKKMTAWMYFVSKTLAEQAAWKYAKENNIDFITIIPTLVVGPFIMSSMPPSLITALSPITGNEAHYSIIRQGQFVHLDDLCNAHIYLFENPKAEGRYICSSHDCIILDLAKMLREKYPEYNIPTEFKGVDENLKSVCFSSKKLTDLGFEFKYSLEDMFTGAVDTCRAKGLLPPSH 3cf8 A 2.4 BS01 QUE A 1 F59 K62 I111 P112 F52 K55 I104 P105 H58 I64 G67 V68 E72 H51 I57 G60 V61 E65 4.2.1.59 0005737,0006633,0009245,0016829,0016836,0019171 Ki=12.7uM -logKd/Ki=4.90, Ki=12.7uM Q5G940 18780820 164 LQSQFFIEHILQILPHRYPMLLVDRITELQANQKIVAYKNITFNEDVFNGHFPNKPIFPGVLIVEGMAQSGGFLAFTSLWGFDPEIAKTKIVYFMTIDKVKFRIPVTPGDRLEYHLEVLKHKGMIWQVGGTAQVDGKVVAEAELKAMIAERE 3cf8 B 2.4 BS01 QUE A 1 I98 Y100 I88 Y90 H58 I64 G67 V68 E72 H48 I54 G57 V58 E62 4.2.1.59 0005737,0006633,0009245,0016829,0016836,0019171 -logKd/Ki=4.90, Ki=12.7uM Q5G940 18780820 164 QFFIEHILQILPHRYPMLLVDRITELQANQKIVAYKNITFNEDVFNGHFPNKPIFPGVLIVEGMAQSGGFLAFTSLWGFDPEIAKTKIVYFMTIDKVKFRIPVTPGDRLEYHLEVLKHKGMIWQVGGTAQVDGKVVAEAELKAMIAERE 3cf8 C 2.4 BS01 QUE C 1 L21 P22 H23 I98 V99 L13 P14 H15 I90 V91 H58 I64 G67 V68 E72 H50 I56 G59 V60 E64 4.2.1.59 0005737,0006633,0009245,0016829,0016836,0019171 Ki=12.7uM Q5G940 18780820 162 QSQFFIEHILQILPHRYPMLLVDRITELQANQKIVAYKNITFNEDVFNGHFPNKPIFPGVLIVEGMAQSGGFLAFTSLWGFDPEIAKTKIVYFMTIDKVKFRIPVTPGDRLEYHLEVLKHKGMIWQVGGTAQVDGKVVAEAELKAMIAER 3lj0 A 3.2 BS03 QUE A 1 S984 K985 K992 E1111 F1112 S276 K277 K284 E403 F404 D797 K799 N802 D828 T852 D120 K122 N125 D151 T168 2.7.11.1,3.1.26.- 0004521,0004540,0004672,0004674,0005524,0006397,0006468,0030968 P32361 20417606 1 NFEQSLKNLVVSEKILGYGSSGTVVFQGSFQGRPVAVKRMLIDFCDIALMEIKLLTESDDHPNVIRYYCSETTDRFLYIALELCNLNLQDLVESYNPISLLRQIASGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRESNIIRGIFSLDEMKCLHDRSLIAEATDLISQMIDHDPLKRPTAMKVLRHPLFWPKSKKLEFLLKVSDRLEIENRDPPSALLMKFDAGSDFVIPSGDWTVKFDKTFMDNLERYRKYHSSKLMDLLRALRNKYHHFMDLPEDIAELMGPVPDGFYDYFTKRFPNLLIGVYMIVKENLSDDQILREFLYS 3lj0 A 3.2 BS04 QUE B 1 E988 P1077 E280 P369 D797 K799 N802 D828 T852 D120 K122 N125 D151 T168 2.7.11.1,3.1.26.- 0004521,0004540,0004672,0004674,0005524,0006397,0006468,0030968 P32361 20417606 1 NFEQSLKNLVVSEKILGYGSSGTVVFQGSFQGRPVAVKRMLIDFCDIALMEIKLLTESDDHPNVIRYYCSETTDRFLYIALELCNLNLQDLVESYNPISLLRQIASGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRESNIIRGIFSLDEMKCLHDRSLIAEATDLISQMIDHDPLKRPTAMKVLRHPLFWPKSKKLEFLLKVSDRLEIENRDPPSALLMKFDAGSDFVIPSGDWTVKFDKTFMDNLERYRKYHSSKLMDLLRALRNKYHHFMDLPEDIAELMGPVPDGFYDYFTKRFPNLLIGVYMIVKENLSDDQILREFLYS 3lj0 B 3.2 BS03 QUE B 1 S984 K985 K992 E1111 F1112 S271 K272 K279 E398 F399 D797 K799 N802 D828 T852 D115 K117 N120 D146 T163 2.7.11.1,3.1.26.- 0004521,0004540,0004672,0004674,0005524,0006397,0006468,0030968 P32361 20417606 1 LKNLVVSEKILGYGSSGTVVFQGSFQGRPVAVKRMLIDFCDIALMEIKLLTESDDHPNVIRYYCSETTDRFLYIALELCNLNLQDLVESYNPISLLRQIASGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRESNIIRGIFSLDEMKCLHDRSLIAEATDLISQMIDHDPLKRPTAMKVLRHPLFWPKSKKLEFLLKVSDRLEIENRDPPSALLMKFDAGSDFVIPSGDWTVKFDKTFMDNLERYRKYHSSKLMDLLRALRNKYHHFMDLPEDIAELMGPVPDGFYDYFTKRFPNLLIGVYMIVKENLSDDQILREFLYS 3lm5 A 2.29 BS01 QUE A 1 A60 K62 E80 I94 L110 E111 Y112 L165 V178 D179 A43 K45 E63 I77 L93 E94 Y95 L147 V160 D161 D158 K160 Q162 N163 D179 T198 D140 K142 Q144 N145 D161 T171 2.7.11.1 0004672,0004674,0005524,0006468 O94768 33215924 1 ENLYFQSMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIMGTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWDFENL 3nvy C 2.0 BS01 QUE C 1 L648 E802 L873 R880 F914 F1009 T1010 L1014 A1079 L78 E232 L303 R310 F344 F439 T440 L444 A509 Q767 E802 R880 H884 R912 G1260 E1261 Q197 E232 R310 H314 R342 G690 E691 1.17.1.4,1.17.3.2 0005506,0016491,0043546 Ki=1200nM, IC50=31900nM P80457 25060641 1356 DTVGRPLPHLAAAMQASGEAVYCDDIPRYENELFLRLVTSTRAHAKIKSIDVSEAQKVPGFVCFLSADDIPGSNETGLFNDETVFAKDTVTCVGHIIGAVVADTPEHAERAAHVVKVTYEDLPAIITIEDAIKNNSFYGSELKIEKGDLKKGFSEADNVVSGELYIGGQDHFYLETHCTIAIPKGEEGEMELFVSTQNAMKTQSFVAKMLGVPVNRILVRVKRMGGGFGGKETRSTLVSVAVALAAYKTGHPVRCMLDRNEDMLITGGRHPFLARYKVGFMKTGTIVALEVDHYSNAGNSRDLSHSIMERALFHMDNCYKIPNIRGTGRLCKTNLSSNTAFRGFGGPQALFIAENWMSEVAVTCGLPAEEVRWKNMYKEGDLTHFNQRLEGFSVPRCWDECLKSSQYYARKSEVDKFNKENCWKKRGLCIIPTKFGISFTVPFLNQAGALIHVYTDGSVLVSHGGTEMGQGLHTKMVQVASKALKIPISKIYISETSTNTVPNSSPTAASVSTDIYGQAVYEACQTILKRLEPFKKKNPDGSWEDWVMAAYQDRVSLSTTGFYRTPNLGYSFETNSGNAFHYFTYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIGQVEGAFVQGLGLFTLEELHYSPEGSLHTRGPSTYKIPAFGSIPTEFRVSLLRDCPNKKAIYASKAVGEPPLFLGASVFFAIKDAIRAARAQHTNNNTKELFRLDSPATPEKIRNACVDKFTTLCVTGAPGNCK 3nvy L 2.0 BS01 QUE L 1 L648 E802 L873 R880 F914 F1009 T1010 V1011 L1014 A1079 L78 E232 L303 R310 F344 F439 T440 V441 L444 A509 H884 R912 E1261 H314 R342 E691 1.17.1.4,1.17.3.2 0005506,0016491,0043546 Ki=1200nM, IC50=31900nM P80457 25060641 1356 DTVGRPLPHLAAAMQASGEAVYCDDIPRYENELFLRLVTSTRAHAKIKSIDVSEAQKVPGFVCFLSADDIPGSNETGLFNDETVFAKDTVTCVGHIIGAVVADTPEHAERAAHVVKVTYEDLPAIITIEDAIKNNSFYGSELKIEKGDLKKGFSEADNVVSGELYIGGQDHFYLETHCTIAIPKGEEGEMELFVSTQNAMKTQSFVAKMLGVPVNRILVRVKRMGGGFGGKETRSTLVSVAVALAAYKTGHPVRCMLDRNEDMLITGGRHPFLARYKVGFMKTGTIVALEVDHYSNAGNSRDLSHSIMERALFHMDNCYKIPNIRGTGRLCKTNLSSNTAFRGFGGPQALFIAENWMSEVAVTCGLPAEEVRWKNMYKEGDLTHFNQRLEGFSVPRCWDECLKSSQYYARKSEVDKFNKENCWKKRGLCIIPTKFGISFTVPFLNQAGALIHVYTDGSVLVSHGGTEMGQGLHTKMVQVASKALKIPISKIYISETSTNTVPNSSPTAASVSTDIYGQAVYEACQTILKRLEPFKKKNPDGSWEDWVMAAYQDRVSLSTTGFYRTPNLGYSFETNSGNAFHYFTYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIGQVEGAFVQGLGLFTLEELHYSPEGSLHTRGPSTYKIPAFGSIPTEFRVSLLRDCPNKKAIYASKAVGEPPLFLGASVFFAIKDAIRAARAQHTNNNTKELFRLDSPATPEKIRNACVDKFTT 4dfu A 1.98 BS02 QUE A 1 I44 K46 K97 I98 G100 P102 I216 D217 I42 K44 K95 I96 G98 P100 I214 D215 ? 0000166,0046872 Ki=25.1uM -logKd/Ki=4.60, Ki=25.1uM O68183 22195561 402 TYTFDQVEKAIEQLYPDFTINTIEISGEGNDCIAYEINRDFIFKFPKHSRGSTNLFNEVNILKRIHNKLPLPIPEVVFTGMPSETYQMSFAGFTKIKGVPLTPLLLNNLPKQSQNQAAKDLARFLSELHSINISGFKSNLVLDFREKINEDNKKIKKLLSRELKGPQMKKVDDFYRDILENEIYFKYYPCLIHNDFSSDHILFDTEKNTICGIIDFGDAAISDPDNDFISLMEDDEEYGMEFVSKILNHYKHKDIPTVLEKYRMKEKYWSFEKIIYGKEYGYMDWYEEGLNEIRSI 4dfu A 1.98 BS03 QUE B 1 R52 T55 T87 Y88 Q89 R50 T53 T85 Y86 Q87 ? 0000166,0046872 Ki=25.1uM -logKd/Ki=4.60, Ki=25.1uM O68183 22195561 401 TYTFDQVEKAIEQLYPDFTINTIEISGEGNDCIAYEINRDFIFKFPKHSRGSTNLFNEVNILKRIHNKLPLPIPEVVFTGMPSETYQMSFAGFTKIKGVPLTPLLLNNLPKQSQNQAAKDLARFLSELHSINISGFKSNLVLDFREKINEDNKKIKKLLSRELKGPQMKKVDDFYRDILENEIYFKYYPCLIHNDFSSDHILFDTEKNTICGIIDFGDAAISDPDNDFISLMEDDEEYGMEFVSKILNHYKHKDIPTVLEKYRMKEKYWSFEKIIYGKEYGYMDWYEEGLNEIRSI 4dfu B 1.98 BS01 QUE B 1 S51 R52 T55 S85 T87 Y88 Q89 S49 R50 T53 S83 T85 Y86 Q87 ? 0000166,0046872 Ki=25.1uM O68183 22195561 401 TYTFDQVEKAIEQLYPDFTINTIEISGEGNDCIAYEINRDFIFKFPKHSRGSTNLFNEVNILKRIHNKLPLPIPEVVFTGMPSETYQMSFAGFTKIKGVPLTPLLLNNLPKQSQNQAAKDLARFLSELHSINISGFKSNLVLDFREKINEDNKKIKKLLSRELKGPQMKKVDDFYRDILENEIYFKYYPCLIHNDFSSDHILFDTEKNTICGIIDFGDAAISDPDNDFISLMEDDEEYGMEFVSKILNHYKHKDIPTVLEKYRMKEKYWSFEKIIYGKEYGYMDWYEEGLNEIRSIK 4dfu B 1.98 BS03 QUE B 2 I44 K46 P76 F95 T96 K97 I98 P102 L204 I216 I42 K44 P74 F93 T94 K95 I96 P100 L202 I214 ? 0000166,0046872 Ki=25.1uM O68183 22195561 403 TYTFDQVEKAIEQLYPDFTINTIEISGEGNDCIAYEINRDFIFKFPKHSRGSTNLFNEVNILKRIHNKLPLPIPEVVFTGMPSETYQMSFAGFTKIKGVPLTPLLLNNLPKQSQNQAAKDLARFLSELHSINISGFKSNLVLDFREKINEDNKKIKKLLSRELKGPQMKKVDDFYRDILENEIYFKYYPCLIHNDFSSDHILFDTEKNTICGIIDFGDAAISDPDNDFISLMEDDEEYGMEFVSKILNHYKHKDIPTVLEKYRMKEKYWSFEKIIYGKEYGYMDWYEEGLNEIRSIK 4lmu A 2.38 BS01 QUE A 1 L44 A65 K67 L120 E121 R122 V126 L174 I185 D186 L9 A30 K32 L81 E82 R83 V87 L135 I146 D147 D167 K169 N172 D186 L193 T204 D128 K130 N133 D147 L154 T165 2.7.11.1 0004672,0004674,0005515,0005524,0005634,0005654,0005730,0005737,0005829,0005886,0006338,0006468,0006915,0008134,0016310,0022898,0030145,0043024,0043066,0043433,0044024,0045824,0045893,0046777,0046872,0050821,0060045,0070561,0071346,0090336,0106310,1902033,1904263,1905062,1990748 -logKd/Ki=7.26, IC50=55nM IC50=1100nM, Kd=25nM P11309 24531473 401 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGETRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHL 4mra A 2.34 BS01 QUE A 1 E121 E124 K544 Y548 R551 K655 E110 E113 K515 Y519 R522 K626 H377 K568 R569 K574 T676 K680 H348 K539 R540 K545 T647 K651 2.4.1.1 0000166,0004645,0005737,0005975,0005977,0005980,0008184,0016757,0030170,0098723,0102250,0102499 ic50=33.5uM -logKd/Ki=4.47, IC50=33.5uM P00489 24556570 901 QISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTVRDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDMEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKICGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGRVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPNDGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSTNFDAFPDKVAIQLNDTHPSLAIPELMRVLVDLERLDWDKAWEVTVKTCAYTNHTVLPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAAAFPGDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKFQNKTNGITPRRWLVLCNPGLAEIIAERIGEEYISDLDQLRKLLSYVDDEAFIRDVAKVKQENKLKFAAYLEREYKVHINPNSLFDVQVKRIHEYKRQLLNCLHVITLYNRIKKEPNKFVVPRTVMIGGKAAPGYHMAKMIIKLITAIGDVVNHDPVVGDRLRVIFLENYRVSLAEKVIPAADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVDRLDQRGYNAQEYYDRIPELRQIIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEEYVKCQERVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPA 4wnj B 1.398 BS01 QUE B 1 K15 L17 A108 L110 S117 K6 L8 A99 L101 S108 ? 0005179,0005515,0005576,0005615,0005737,0006144,0007165,0035578,0042802,0070062,0070324 P02766 26249340 201 CPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTN 5a4v A 2.38 BS01 QUE B 1 H77 I94 Y97 H76 I93 Y96 2.5.1.18 0000325,0002239,0004364,0004601,0005737,0005783,0005829,0005886,0006952,0009407,0009409,0009506,0009507,0009570,0009636,0009734,0010043,0016740,0019904,0043231,0043295,0046686,0048046,0098869,1901149,2001147,2001227 P46422 28174680 1213 AGIKVFGHPASIATRRVLIALHEKNLDFELVHVELKDGEHKKEPFLSRNPFGQVPAFEDGDLKLFESRAITQYIAHRYENQGTNLLQTDSKNISQYAIMAIGMQVEDHQFDPVASKLAFEQIFKSIYGLTTDEAVVAEEEAKLAKVLDVYEARLKEFKYLAGETFTLTDLHHIPAIQYLLGTPTKKLFTERPRVNEWVAEITKRPASEKVQ 5a4v B 2.38 BS01 QUE B 1 Q73 H77 Y97 Q71 H75 Y95 2.5.1.18 0000325,0002239,0004364,0004601,0005737,0005783,0005829,0005886,0006952,0009407,0009409,0009506,0009507,0009570,0009636,0009734,0010043,0016740,0019904,0043231,0043295,0046686,0048046,0098869,1901149,2001147,2001227 P46422 28174680 1213 GIKVFGHPASIATRRVLIALHEKNLDFELVHVELKDGEHKKEPFLSRNPFGQVPAFEDGDLKLFESRAITQYIAHRYENQGTNLLQTDSKNISQYAIMAIGMQVEDHQFDPVASKLAFEQIFKSIYGLTTDEAVVAEEEAKLAKVLDVYEARLKEFKYLAGETFTLTDLHHIPAIQYLLGTPTKKLFTERPRVNEWVAEITKRPASEKVQ 5a4v C 2.38 BS01 QUE D 1 Q73 H77 Y97 Q72 H76 Y96 2.5.1.18 0000325,0002239,0004364,0004601,0005737,0005783,0005829,0005886,0006952,0009407,0009409,0009506,0009507,0009570,0009636,0009734,0010043,0016740,0019904,0043231,0043295,0046686,0048046,0098869,1901149,2001147,2001227 P46422 28174680 1213 AGIKVFGHPASIATRRVLIALHEKNLDFELVHVELKDGEHKKEPFLSRNPFGQVPAFEDGDLKLFESRAITQYIAHRYENQGTNLLQTDSKNISQYAIMAIGMQVEDHQFDPVASKLAFEQIFKSIYGLTTDEAVVAEEEAKLAKVLDVYEARLKEFKYLAGETFTLTDLHHIPAIQYLLGTPTKKLFTERPRVNEWVAEITKRPASEKVQ 5a4v D 2.38 BS01 QUE D 1 H77 Y97 H76 Y96 2.5.1.18 0000325,0002239,0004364,0004601,0005737,0005783,0005829,0005886,0006952,0009407,0009409,0009506,0009507,0009570,0009636,0009734,0010043,0016740,0019904,0043231,0043295,0046686,0048046,0098869,1901149,2001147,2001227 P46422 28174680 1213 AGIKVFGHPASIATRRVLIALHEKNLDFELVHVELKDGEHKKEPFLSRNPFGQVPAFEDGDLKLFESRAITQYIAHRYENQGTNLLQTDSKNISQYAIMAIGMQVEDHQFDPVASKLAFEQIFKSIYGLTTDEAVVAEEEAKLAKVLDVYEARLKEFKYLAGETFTLTDLHHIPAIQYLLGTPTKKLFTERPRVNEWVAEITKRPASEKVQ 5a4v E 2.38 BS01 QUE F 1 Q73 Y74 H77 Y97 Q72 Y73 H76 Y96 2.5.1.18 0000325,0002239,0004364,0004601,0005737,0005783,0005829,0005886,0006952,0009407,0009409,0009506,0009507,0009570,0009636,0009734,0010043,0016740,0019904,0043231,0043295,0046686,0048046,0098869,1901149,2001147,2001227 P46422 28174680 1213 AGIKVFGHPASIATRRVLIALHEKNLDFELVHVELKDGEHKKEPFLSRNPFGQVPAFEDGDLKLFESRAITQYIAHRYENQGTNLLQTDSKNISQYAIMAIGMQVEDHQFDPVASKLAFEQIFKSIYGLTTDEAVVAEEEAKLAKVLDVYEARLKEFKYLAGETFTLTDLHHIPAIQYLLGTPTKKLFTERPRVNEWVAEITKRPASEKVQ 5a4v F 2.38 BS01 QUE F 1 Q73 H77 I94 Y97 A101 Q71 H75 I92 Y95 A99 2.5.1.18 0000325,0002239,0004364,0004601,0005737,0005783,0005829,0005886,0006952,0009407,0009409,0009506,0009507,0009570,0009636,0009734,0010043,0016740,0019904,0043231,0043295,0046686,0048046,0098869,1901149,2001147,2001227 P46422 28174680 1213 GIKVFGHPASIATRRVLIALHEKNLDFELVHVELKDGEHKKEPFLSRNPFGQVPAFEDGDLKLFESRAITQYIAHRYENQGTNLLQTDSKNISQYAIMAIGMQVEDHQFDPVASKLAFEQIFKSIYGLVAEEEAKLAKVLDVYEARLKEFKYLAGETFTLTDLHHIPAIQYLLGTPTKKLFTERPRVNEWVAEITKRPASEKVQ 5auw A 1.5 BS01 QUE A 1 L19 A40 K42 E64 I77 L93 E94 L95 V96 I160 D161 F162 L18 A39 K41 E63 I76 L92 E93 L94 V95 I157 D158 F159 D139 K141 E143 N144 D161 T180 D136 K138 E140 N141 D158 T177 2.7.11.1 0004672,0005524,0006468 ic50=8.9uM -logKd/Ki=5.05, IC50=8.9uM IC50=8900nM P53355 26322379 400 TVFRQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIKP 5fli A 2.15 BS02 QUE A 1 L35 F56 C58 H69 H71 E76 V77 F78 F140 F141 F176 L33 F54 C56 H67 H69 E74 V75 F76 F138 F139 F174 H69 H71 E76 H115 H67 H69 E74 H113 1.13.11.24 A2VA43 26846734 301 IEYATRHRARSFIPPEPGKPYFIEKGLGDRAHLFGDLITIYAGGEQTENTFNFFTCEGPKGEVIPAHSHADTYEVFYITQGAVRLFVEDLEGEQHEKLLTPGDFGFVPKNCVHAYRMERHHSQVVGVAAGPGGTFERFFESLGTPAEELGLPVRPFVPEPEKFRTVPEQYDVRFRPDHQWHTG 5fli B 2.15 BS02 QUE B 1 L35 C58 I66 H69 H71 E76 V77 F78 F140 F141 L33 C56 I64 H67 H69 E74 V75 F76 F138 F139 H69 H71 E76 H115 H67 H69 E74 H113 1.13.11.24 A2VA43 26846734 301 IEYATRHRARSFIPPEPGKPYFIEKGLGDRAHLFGDLITIYAGGEQTENTFNFFTCEGPKGEVIPAHSHADTYEVFYITQGAVRLFVEDLEGEQHEKLLTPGDFGFVPKNCVHAYRMERHHSQVVGVAAGPGGTFERFFESLGTPAEELGLPVRPFVPEPEKFRTVPEQYDVRFRPDHQWHTG 5fli C 2.15 BS02 QUE C 1 L35 C58 H69 H71 E76 V77 Y117 F140 F141 L33 C56 H67 H69 E74 V75 Y115 F138 F139 H69 H71 E76 H115 H67 H69 E74 H113 1.13.11.24 A2VA43 26846734 301 IEYATRHRARSFIPPEPGKPYFIEKGLGDRAHLFGDLITIYAGGEQTENTFNFFTCEGPKGEVIPAHSHADTYEVFYITQGAVRLFVEDLEGEQHEKLLTPGDFGFVPKNCVHAYRMERHHSQVVGVAAGPGGTFERFFESLGTPAEELGLPVRPFVPEPEKFRTVPEQYDVRFRPDHQWHTG 5fli D 2.15 BS02 QUE D 1 L35 F56 I66 H69 H71 E76 V77 Y117 F140 F141 L33 F54 I64 H67 H69 E74 V75 Y115 F138 F139 H69 H71 E76 H115 H67 H69 E74 H113 1.13.11.24 A2VA43 26846734 301 IEYATRHRARSFIPPEPGKPYFIEKGLGDRAHLFGDLITIYAGGEQTENTFNFFTCEGPKGEVIPAHSHADTYEVFYITQGAVRLFVEDLEGEQHEKLLTPGDFGFVPKNCVHAYRMERHHSQVVGVAAGPGGTFERFFESLGTPAEELGLPVRPFVPEPEKFRTVPEQYDVRFRPDHQWHTG 5fli E 2.15 BS02 QUE E 1 L35 F36 F56 I66 H69 H71 E76 V77 F78 Y117 F140 F141 L33 F34 F54 I64 H67 H69 E74 V75 F76 Y115 F138 F139 H69 H71 E76 H115 H67 H69 E74 H113 1.13.11.24 A2VA43 26846734 301 IEYATRHRARSFIPPEPGKPYFIEKGLGDRAHLFGDLITIYAGGEQTENTFNFFTCEGPKGEVIPAHSHADTYEVFYITQGAVRLFVEDLEGEQHEKLLTPGDFGFVPKNCVHAYRMERHHSQVVGVAAGPGGTFERFFESLGTPAEELGLPVRPFVPEPEKFRTVPEQYDVRFRPDHQWHTG 5fli F 2.15 BS02 QUE F 1 L35 F56 I66 H69 H71 E76 V77 Y117 F140 F141 L33 F54 I64 H67 H69 E74 V75 Y115 F138 F139 H69 H71 E76 H115 H67 H69 E74 H113 1.13.11.24 A2VA43 26846734 301 IEYATRHRARSFIPPEPGKPYFIEKGLGDRAHLFGDLITIYAGGEQTENTFNFFTCEGPKGEVIPAHSHADTYEVFYITQGAVRLFVEDLEGEQHEKLLTPGDFGFVPKNCVHAYRMERHHSQVVGVAAGPGGTFERFFESLGTPAEELGLPVRPFVPEPEKFRTVPEQYDVRFRPDHQWHTG 5fli G 2.15 BS02 QUE G 1 L35 C58 H69 H71 E76 V77 F78 F140 F141 L33 C56 H67 H69 E74 V75 F76 F138 F139 H69 H71 E76 H115 H67 H69 E74 H113 1.13.11.24 A2VA43 26846734 301 IEYATRHRARSFIPPEPGKPYFIEKGLGDRAHLFGDLITIYAGGEQTENTFNFFTCEGPKGEVIPAHSHADTYEVFYITQGAVRLFVEDLEGEQHEKLLTPGDFGFVPKNCVHAYRMERHHSQVVGVAAGPGGTFERFFESLGTPAEELGLPVRPFVPEPEKFRTVPEQYDVRFRPDHQWHTG 5fli H 2.15 BS02 QUE H 1 L35 F36 F56 H69 H71 E76 V77 F78 Y117 F140 F141 L33 F34 F54 H67 H69 E74 V75 F76 Y115 F138 F139 H69 H71 E76 H115 H67 H69 E74 H113 1.13.11.24 A2VA43 26846734 301 IEYATRHRARSFIPPEPGKPYFIEKGLGDRAHLFGDLITIYAGGEQTENTFNFFTCEGPKGEVIPAHSHADTYEVFYITQGAVRLFVEDLEGEQHEKLLTPGDFGFVPKNCVHAYRMERHHSQVVGVAAGPGGTFERFFESLGTPAEELGLPVRPFVPEPEKFRTVPEQYDVRFRPDHQWHTG 5fli J 2.15 BS02 QUE J 1 L35 F36 C58 I66 H69 H71 E76 V77 F78 Y117 F140 F141 L33 F34 C56 I64 H67 H69 E74 V75 F76 Y115 F138 F139 H69 H71 E76 H115 H67 H69 E74 H113 1.13.11.24 A2VA43 26846734 301 IEYATRHRARSFIPPEPGKPYFIEKGLGDRAHLFGDLITIYAGGEQTENTFNFFTCEGPKGEVIPAHSHADTYEVFYITQGAVRLFVEDLEGEQHEKLLTPGDFGFVPKNCVHAYRMERHHSQVVGVAAGPGGTFERFFESLGTPAEELGLPVRPFVPEPEKFRTVPEQYDVRFRPDHQWHTG 5fli K 2.15 BS02 QUE K 1 L35 F56 H69 H71 E76 V77 Y117 F140 F141 F176 L33 F54 H67 H69 E74 V75 Y115 F138 F139 F174 H69 H71 E76 H115 H67 H69 E74 H113 1.13.11.24 A2VA43 26846734 301 IEYATRHRARSFIPPEPGKPYFIEKGLGDRAHLFGDLITIYAGGEQTENTFNFFTCEGPKGEVIPAHSHADTYEVFYITQGAVRLFVEDLEGEQHEKLLTPGDFGFVPKNCVHAYRMERHHSQVVGVAAGPGGTFERFFESLGTPAEELGLPVRPFVPEPEKFRTVPEQYDVRFRPDHQWHTG 5fli L 2.15 BS02 QUE L 1 L35 F36 F56 I66 H69 H71 E76 V77 F78 Y117 F140 F141 F176 L33 F34 F54 I64 H67 H69 E74 V75 F76 Y115 F138 F139 F174 H69 H71 E76 H115 H67 H69 E74 H113 1.13.11.24 A2VA43 26846734 301 IEYATRHRARSFIPPEPGKPYFIEKGLGDRAHLFGDLITIYAGGEQTENTFNFFTCEGPKGEVIPAHSHADTYEVFYITQGAVRLFVEDLEGEQHEKLLTPGDFGFVPKNCVHAYRMERHHSQVVGVAAGPGGTFERFFESLGTPAEELGLPVRPFVPEPEKFRTVPEQYDVRFRPDHQWHTG 5flj A 1.818 BS02 QUE A 1 L35 F36 I66 H69 H71 E76 V77 F78 Y117 F140 F141 L33 F34 I64 H67 H69 E74 V75 F76 Y115 F138 F139 H69 H71 E76 H115 H67 H69 E74 H113 1.13.11.24 A2VA43 26846734 301 IEYATRHRARSFIPPEPGKPYFIEKGLGDRAHLFGDLITIYAGGEQTENTFNFFTCEGPKGEVIPAHSHADTYEVFYITQGAVRLFVEDLEGEQHEKLLTPGDFGFVPKNCVHAYRMERHHSQVVGVAAGPGGTFERFFESLGTPAEELGLPVRPFVPEPEKFRTVPEQYDVRFRPDHQWHT 5flj B 1.818 BS02 QUE B 1 L35 F56 I66 H69 H71 E76 V77 F78 Y117 F140 F141 L33 F54 I64 H67 H69 E74 V75 F76 Y115 F138 F139 H69 H71 E76 H115 H67 H69 E74 H113 1.13.11.24 A2VA43 26846734 301 IEYATRHRARSFIPPEPGKPYFIEKGLGDRAHLFGDLITIYAGGEQTENTFNFFTCEGPKGEVIPAHSHADTYEVFYITQGAVRLFVEDLEGEQHEKLLTPGDFGFVPKNCVHAYRMERHHSQVVGVAAGPGGTFERFFESLGTPAEELGLPVRPFVPEPEKFRTVPEQYDVRFRPDHQWHTG 5flj C 1.818 BS02 QUE C 1 L35 F56 C58 I66 H69 H71 E76 V77 F78 F140 F141 L33 F54 C56 I64 H67 H69 E74 V75 F76 F138 F139 H69 H71 E76 H115 H67 H69 E74 H113 1.13.11.24 A2VA43 26846734 301 IEYATRHRARSFIPPEPGKPYFIEKGLGDRAHLFGDLITIYAGGEQTENTFNFFTCEGPKGEVIPAHSHADTYEVFYITQGAVRLFVEDLEGEQHEKLLTPGDFGFVPKNCVHAYRMERHHSQVVGVAAGPGGTFERFFESLGTPAEELGLPVRPFVPEPEKFRTVPEQYDVRFRPDHQWHTG 5flj D 1.818 BS02 QUE D 1 L35 F56 I66 H69 H71 E76 V77 F78 Y117 F140 F141 L33 F54 I64 H67 H69 E74 V75 F76 Y115 F138 F139 H69 H71 E76 H115 H67 H69 E74 H113 1.13.11.24 A2VA43 26846734 301 IEYATRHRARSFIPPEPGKPYFIEKGLGDRAHLFGDLITIYAGGEQTENTFNFFTCEGPKGEVIPAHSHADTYEVFYITQGAVRLFVEDLEGEQHEKLLTPGDFGFVPKNCVHAYRMERHHSQVVGVAAGPGGTFERFFESLGTPAEELGLPVRPFVPEPEKFRTVPEQYDVRFRPDHQWHTG 5flj E 1.818 BS02 QUE E 1 L35 F56 C58 I66 H69 H71 E76 V77 F78 F140 F141 L33 F54 C56 I64 H67 H69 E74 V75 F76 F138 F139 H69 H71 E76 H115 H67 H69 E74 H113 1.13.11.24 A2VA43 26846734 301 IEYATRHRARSFIPPEPGKPYFIEKGLGDRAHLFGDLITIYAGGEQTENTFNFFTCEGPKGEVIPAHSHADTYEVFYITQGAVRLFVEDLEGEQHEKLLTPGDFGFVPKNCVHAYRMERHHSQVVGVAAGPGGTFERFFESLGTPAEELGLPVRPFVPEPEKFRTVPEQYDVRFRPDHQWHTG 5flj F 1.818 BS02 QUE F 1 L35 F56 I66 H69 H71 E76 V77 F78 F140 F141 L33 F54 I64 H67 H69 E74 V75 F76 F138 F139 H69 H71 E76 H115 H67 H69 E74 H113 1.13.11.24 A2VA43 26846734 301 IEYATRHRARSFIPPEPGKPYFIEKGLGDRAHLFGDLITIYAGGEQTENTFNFFTCEGPKGEVIPAHSHADTYEVFYITQGAVRLFVEDLEGEQHEKLLTPGDFGFVPKNCVHAYRMERHHSQVVGVAAGPGGTFERFFESLGTPAEELGLPVRPFVPEPEKFRTVPEQYDVRFRPDHQWHTG 5flj G 1.818 BS02 QUE G 1 L35 F56 I66 H69 H71 E76 V77 F78 F140 F141 L33 F54 I64 H67 H69 E74 V75 F76 F138 F139 H69 H71 E76 H115 H67 H69 E74 H113 1.13.11.24 A2VA43 26846734 301 IEYATRHRARSFIPPEPGKPYFIEKGLGDRAHLFGDLITIYAGGEQTENTFNFFTCEGPKGEVIPAHSHADTYEVFYITQGAVRLFVEDLEGEQHEKLLTPGDFGFVPKNCVHAYRMERHHSQVVGVAAGPGGTFERFFESLGTPAEELGLPVRPFVPEPEKFRTVPEQYDVRFRPDHQWHTG 5flj H 1.818 BS02 QUE H 1 L35 F56 I66 H69 H71 E76 V77 F78 Y117 F140 F141 L33 F54 I64 H67 H69 E74 V75 F76 Y115 F138 F139 H69 H71 E76 H115 H67 H69 E74 H113 1.13.11.24 A2VA43 26846734 301 IEYATRHRARSFIPPEPGKPYFIEKGLGDRAHLFGDLITIYAGGEQTENTFNFFTCEGPKGEVIPAHSHADTYEVFYITQGAVRLFVEDLEGEQHEKLLTPGDFGFVPKNCVHAYRMERHHSQVVGVAAGPGGTFERFFESLGTPAEELGLPVRPFVPEPEKFRTVPEQYDVRFRPDHQWHTG 5flj I 1.818 BS02 QUE I 1 L35 F36 F56 I66 H69 H71 E76 V77 F78 Y117 F140 F141 L33 F34 F54 I64 H67 H69 E74 V75 F76 Y115 F138 F139 H69 H71 E76 H115 H67 H69 E74 H113 1.13.11.24 A2VA43 26846734 301 IEYATRHRARSFIPPEPGKPYFIEKGLGDRAHLFGDLITIYAGGEQTENTFNFFTCEGPKGEVIPAHSHADTYEVFYITQGAVRLFVEDLEGEQHEKLLTPGDFGFVPKNCVHAYRMERHHSQVVGVAAGPGGTFERFFESLGTPAEELGLPVRPFVPEPEKFRTVPEQYDVRFRPDHQWHTG 5flj J 1.818 BS02 QUE J 1 L35 F36 I66 H69 H71 E76 V77 F78 Y117 F140 F141 L33 F34 I64 H67 H69 E74 V75 F76 Y115 F138 F139 H69 H71 E76 H115 H67 H69 E74 H113 1.13.11.24 A2VA43 26846734 301 IEYATRHRARSFIPPEPGKPYFIEKGLGDRAHLFGDLITIYAGGEQTENTFNFFTCEGPKGEVIPAHSHADTYEVFYITQGAVRLFVEDLEGEQHEKLLTPGDFGFVPKNCVHAYRMERHHSQVVGVAAGPGGTFERFFESLGTPAEELGLPVRPFVPEPEKFRTVPEQYDVRFRPDHQWHTG 5flj K 1.818 BS02 QUE K 1 L35 F56 I66 H69 H71 E76 V77 F78 Y117 F140 F141 L33 F54 I64 H67 H69 E74 V75 F76 Y115 F138 F139 H69 H71 E76 H115 H67 H69 E74 H113 1.13.11.24 A2VA43 26846734 301 IEYATRHRARSFIPPEPGKPYFIEKGLGDRAHLFGDLITIYAGGEQTENTFNFFTCEGPKGEVIPAHSHADTYEVFYITQGAVRLFVEDLEGEQHEKLLTPGDFGFVPKNCVHAYRMERHHSQVVGVAAGPGGTFERFFESLGTPAEELGLPVRPFVPEPEKFRTVPEQYDVRFRPDHQWHTG 5flj L 1.818 BS02 QUE L 1 L35 F56 H69 H71 E76 V77 F78 Y117 F140 F141 L34 F55 H68 H70 E75 V76 F77 Y116 F139 F140 H69 H71 E76 H115 H68 H70 E75 H114 1.13.11.24 A2VA43 26846734 301 TIEYATRHRARSFIPPEPGKPYFIEKGLGDRAHLFGDLITIYAGGEQTENTFNFFTCEGPKGEVIPAHSHADTYEVFYITQGAVRLFVEDLEGEQHEKLLTPGDFGFVPKNCVHAYRMERHHSQVVGVAAGPGGTFERFFESLGTPAEELGLPVRPFVPEPEKFRTVPEQYDVRFRPDHQWHTG 5xg4 U 3.0 BS01 QUE U 1 H57 H99 S190 S195 S214 W215 G216 G219 H46 H94 S193 S198 S217 W218 G219 G221 3.4.21.73 0004252,0006508 -logKd/Ki=5.15, IC50=7uM IC50=20000nM P00749 28644504 301 IIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTIALPSMYNDPQFGTSCEITGFGKEQSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTK 6aws A 2.35 BS01 QUE A 1 D8 E9 I10 M23 T101 G113 K114 L115 G139 E140 L142 D7 E8 I9 M22 T100 G112 K113 L114 G138 E139 L141 ? 0004864,0005634,0005737,0006952,0009738,0010427,0038023 Q6VT83 202 GVFTFEDEITSTVPPAKLYNAMKDADSITPKIIDDVKSVEIVEGNGGPGTIKKLTIVEDGETKFILHKVESIDEANYAYNYSVVGGVALPPTAEKITFETKLVEGPNGGSIGKLTLKYHTKGDAKPDEEELKKGKAKGEGLFRAIEGYVLANPTQY 6aws A 2.35 BS02 QUE A 2 T30 L55 E59 I66 H68 K138 L142 T29 L54 E58 I65 H67 K137 L141 ? 0004864,0005634,0005737,0006952,0009738,0010427,0038023 Q6VT83 206 GVFTFEDEITSTVPPAKLYNAMKDADSITPKIIDDVKSVEIVEGNGGPGTIKKLTIVEDGETKFILHKVESIDEANYAYNYSVVGGVALPPTAEKITFETKLVEGPNGGSIGKLTLKYHTKGDAKPDEEELKKGKAKGEGLFRAIEGYVLANPTQY 6aws A 2.35 BS03 QUE A 3 F6 D8 Y82 F99 L115 L117 L132 G135 K136 G139 F5 D7 Y81 F98 L114 L116 L131 G134 K135 G138 ? 0004864,0005634,0005737,0006952,0009738,0010427,0038023 Q6VT83 207 GVFTFEDEITSTVPPAKLYNAMKDADSITPKIIDDVKSVEIVEGNGGPGTIKKLTIVEDGETKFILHKVESIDEANYAYNYSVVGGVALPPTAEKITFETKLVEGPNGGSIGKLTLKYHTKGDAKPDEEELKKGKAKGEGLFRAIEGYVLANPTQY 6aws C 2.35 BS01 QUE C 1 D8 E9 I10 M23 T101 G113 K114 L115 D7 E8 I9 M22 T100 G112 K113 L114 ? 0004864,0005634,0005737,0006952,0009738,0010427,0038023 Q6VT83 202 GVFTFEDEITSTVPPAKLYNAMKDADSITPKIIDDVKSVEIVEGNGGPGTIKKLTIVEDGETKFILHKVESIDEANYAYNYSVVGGVALPPTAEKITFETKLVEGPNGGSIGKLTLKYHTKGDAKPDEEELKKGKAKGEGLFRAIEGYVLANPTQY 6aws C 2.35 BS02 QUE C 2 D8 F99 L115 L117 G135 K136 D7 F98 L114 L116 G134 K135 ? 0004864,0005634,0005737,0006952,0009738,0010427,0038023 Q6VT83 203 GVFTFEDEITSTVPPAKLYNAMKDADSITPKIIDDVKSVEIVEGNGGPGTIKKLTIVEDGETKFILHKVESIDEANYAYNYSVVGGVALPPTAEKITFETKLVEGPNGGSIGKLTLKYHTKGDAKPDEEELKKGKAKGEGLFRAIEGYVLANPTQY 6aws C 2.35 BS03 QUE C 3 E59 I66 H68 A89 E131 K134 K138 E58 I65 H67 A88 E130 K133 K137 ? 0004864,0005634,0005737,0006952,0009738,0010427,0038023 Q6VT83 204 GVFTFEDEITSTVPPAKLYNAMKDADSITPKIIDDVKSVEIVEGNGGPGTIKKLTIVEDGETKFILHKVESIDEANYAYNYSVVGGVALPPTAEKITFETKLVEGPNGGSIGKLTLKYHTKGDAKPDEEELKKGKAKGEGLFRAIEGYVLANPTQY 6b1d A 2.51 BS01 QUE A 1 E59 I66 V88 E131 K138 E58 I65 V87 E130 K137 ? 0004864,0005634,0005737,0006952,0009738,0010427,0038023 Q6VT83 1001 GVFTFEDEITSTVPPAKLYNAMKDADSITPKIIDDVKSVEIVEGNGGPGTIKKLTIVEDGETKFILHKVESIDEANYAYNYSVVGGVALPPTAEKITFETKLVEGPNGGSIGKLTLKYHTKGDAKPDEEELKKGKAKGEGLFRAIEGYVLANPTQY 6b1d C 2.51 BS01 QUE C 1 I57 E59 I66 H68 V88 E131 K138 I56 E58 I65 H67 V87 E130 K137 ? 0004864,0005634,0005737,0006952,0009738,0010427,0038023 Q6VT83 1001 GVFTFEDEITSTVPPAKLYNAMKDADSITPKIIDDVKSVEIVEGNGGPGTIKKLTIVEDGETKFILHKVESIDEANYAYNYSVVGGVALPPTAEKITFETKLVEGPNGGSIGKLTLKYHTKGDAKPDEEELKKGKAKGEGLFRAIEGYVLANPTQY 6ijd A 3.206 BS01 QUE A 1 H21 L88 M156 F164 A355 H15 L82 M150 F158 A322 2.4.1.- 0005576,0005829,0008194,0016757,0051555 Q9LNE6 30893500 900 KKPHVLVIPFPQSGHMVPHLDLTHQILLRGATVTVLVTPKNSSYLDALRSLHSPEHFKTLILPFPSHPCIPSGVESLQQLPLEAIVHMFDALSRLHDPLVDFLSRQPPSDLPDAILGSSFLSPWINKVADAFSIKSISFLPINAHSISVMWAQEDRSFFNDLETATTESYGLVINSFYDLEPEFVETVKTRFLNHHRIWTVGPLLPFKSSIPPAKVSAWLDSCPEDNSVVYVGFGSQIRLTAEQTAALAAALEKSSVRFIWAVPAGFEERVKEKGLVIRGWAPQTMILEHRAVGSYLTHLGWGSVLEGMVGGVMLLAWPMQADHFFNTTLIVDKLRAAVRVGENRDSVPDSDKLARILAESAREDLPERVTLMKLREKAMEAIKEGGSSYKNLDELVAEMCL 6ijd B 3.206 BS01 QUE B 1 H21 E89 M156 A355 H15 E83 M150 A322 2.4.1.- 0005576,0005829,0008194,0016757,0051555 Q9LNE6 30893500 900 KKPHVLVIPFPQSGHMVPHLDLTHQILLRGATVTVLVTPKNSSYLDALRSLHSPEHFKTLILPFPSHPCIPSGVESLQQLPLEAIVHMFDALSRLHDPLVDFLSRQPPSDLPDAILGSSFLSPWINKVADAFSIKSISFLPINAHSISVMWAQEDRSFFNDLETATTESYGLVINSFYDLEPEFVETVKTRFLNHHRIWTVGPLLPFKQSSIPPAKVSAWLDSCPEDNSVVYVGFGSQIRLTAEQTAALAAALEKSSVRFIWAVAGFEERVKEKGLVIRGWAPQTMILEHRAVGSYLTHLGWGSVLEGMVGGVMLLAWPMQADHFFNTTLIVDKLRAAVRVGENRDSVPDSDKLARILAESAREDLPERVTLMKLREKAMEAIKEGGSSYKNLDELVAEMCL 6m89 A 1.85 BS01 QUE A 1 K75 P111 E131 D132 V133 I142 L254 I384 K11 P47 E67 D68 V69 I78 L190 I205 2.7.1.140,2.7.1.151,2.7.1.153 0016301,0032958 ic50=2.3uM -logKd/Ki=5.64, IC50=2.3uM IC50=2300nM Q8NFU5 30624931 1001 ILQHPDGTVLKQLQPPPRGPRELEFYNMVYAADCFDGVLLELRKYLPKYYGIWSPPTAPNDLYLKLEDVTHKFNKPCIMDVKIGQKSYDPFASSEKIQQQVSKYPLMEEIGFLVLGMRVYHVHSDSYETENQHYGRSLTKETIKDGVSRFFHNGYCLRKDAVAASIQKIEKILQWFENQKQLNFYASSLLFVYEGSGGEVEVRMIDFAHVFPSNTIDEGYVYGLKHLISVLRSILDN 6qcd A 1.84 BS03 QUE A 1 I61 P62 F64 V70 F82 F86 V115 M136 M157 I52 P53 F55 V61 F73 F77 V106 M127 M148 P62 D63 F64 R65 N114 D116 H133 P53 D54 F55 R56 N105 D107 H124 2.3.1.-,2.3.1.286,2.4.2.- 0070403 Q8N6T7 31844103 408 PFTADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLE 6qcd B 1.84 BS03 QUE B 1 I61 P62 F64 V70 M136 M157 I47 P48 F50 V56 M122 M143 P62 D63 F64 R65 N114 D116 H133 P48 D49 F50 R51 N100 D102 H119 2.3.1.-,2.3.1.286,2.4.2.- 0070403 Q8N6T7 31844103 407 KGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLE 6qcn B 2.23 BS01 QUE A 1 E120 F235 E65 F180 P94 D95 F96 R97 N168 D170 H187 P39 D40 F41 R42 N113 D115 H132 2.3.1.-,2.3.1.286 0017136,0051287,0070403 Q8IXJ6 31844103 403 ERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQ 6tta A -1.00 BS03 QUE A 1 M67 F70 H122 D124 H189 H250 M25 F28 H80 D82 H147 H208 H120 H122 D124 H189 C208 K211 N220 H250 H78 H80 D82 H147 C166 K169 N178 H208 3.5.2.6 E9NWK5 32426604 303 DQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKL 7vum A 2.319 BS01 QUE A 1 I105 N106 I93 N94 ? 0003697,0006260 P40947 35054774 201 RGVNKVILVGNVGGDPETRYMPNGNAVTNITLATSESERTEWHRVVFFGRLAEIAGEYLRKGSQVYVEGSLRTRKWQGQDGQDRYTTEIVVDINGNMQLLG 7vum C 2.319 BS01 QUE A 1 I105 N108 I88 N91 ? 0003697,0006260 P40947 35054774 201 GVNKVILVGNVGGDPETRYMPNGNAVTNITLATSESERTEWHRVVFFGRLAEIAGEYLRKGSQVYVEGSLRTRKWQGDRYTTEIVVDINGNMQLLG 8gqt D 2.09 BS01 QUE D 1 E166 R188 Q189 T190 Q192 E162 R184 Q185 T186 Q188 2.1.1.56,2.1.1.57,2.7.7.48,2.7.7.50,3.1.13.-,3.4.19.12,3.4.22.-,3.4.22.69,3.6.4.12,3.6.4.13,4.6.1.- 0008233,0019082 P0DTD1 401 SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDVVYCPRHVICTLNPNYEDLLIRKSNHNFLVQAGNVQLRVIGHSMQNCVLKLKVDTANPKTPKYKFVRIQPGQTFSVLACYNGSPSGVYQCAMRPNFTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGNFYGPFVDRQTAQAAGTDTTITVNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYEPLTQDHVDILGPLSAQTGIAVLDMCASLKELLQNGMNGRTILGSALLEDEFTPFDVVRQCSGV 8sfw A 2.75 BS02 QUE A 1 I82 T110 F111 M114 L280 I72 T100 F101 M104 L267 ? 0000166,0008194,0016020,0016757 T1KUK4 502 KSLKILFTALFGPGHLNACLGIGSLLRKRGHQIYFAHFPRHRATIEKHGFLFISLLDYAEPEFPIVDMLPDIGIIAKFAFERMHKLTPLELFRHASGKHTFAGMVNGSKGENYAMMKIVKEYKPDVCLADYLFNMPWMFTVDCPVIPVKSVNPIELYNGPPALTGCSIHDPPSVREEIEQLARKSELELESELEKLFAHFNVPLVSYNYAQQLGIYIYPGPLDYKELGSPKENWVRLDSSIRSSNFELPEKLKDKPGKLIYVSMGSLASAVTELLTMILTPLANSPHRFIVSTGPNGDSIKLYDNMWGDKFINQVALLPKVDLFITHGGSNSLIEGLTAGKPLIAIPQFGDQLDNAQRIADLGLGVRLNLHEFSGEKLLKAIEDVLNDEKINANVARVSEELKKSDSKDKVISLIEKLARDKKL