3qj9 A 2.3 BS01 QJ9 A 1 L192 S193 F194 I238 L404 I407 L429 M436 G485 T488 I491 W531 L164 S165 F166 I210 L376 I379 L401 M408 G457 T460 I463 W503 K142 S217 S218 T236 I238 G239 G240 S241 F244 K114 S189 S190 T208 I210 G211 G212 S213 F216 3.1.1.-,3.5.1.99 0000139,0004040,0005515,0005543,0005783,0005789,0005794,0006631,0008289,0009062,0016020,0016042,0016787,0016788,0017064,0031090,0042802,0045907,0047372,0052651,0098793,0098794,0098978,0150036 ic50=951nM -logKd/Ki=7.00, IC50=0.10uM IC50=60nM P97612 21502526 600 ELETGRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTPQKQ 3qj9 B 2.3 BS01 QJ9 B 1 L192 S193 I238 G239 L380 L404 I407 L429 G485 T488 I491 L159 S160 I205 G206 L347 L371 I374 L396 G452 T455 I458 K142 S217 S218 T236 I238 G239 G240 S241 F244 K109 S184 S185 T203 I205 G206 G207 S208 F211 3.1.1.-,3.5.1.99 0000139,0004040,0005515,0005543,0005783,0005789,0005794,0006631,0008289,0009062,0016020,0016042,0016787,0016788,0017064,0031090,0042802,0045907,0047372,0052651,0098793,0098794,0098978,0150036 ic50=951nM IC50=60nM P97612 21502526 600 RQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTPQKQ