3nef A 2.4 BS01 PYV A 1 I68 V87 A95 S98 E100 H121 L123 Y126 V172 I66 V85 A93 S96 E98 H119 L121 Y124 V165 3.1.3.16 0004864,0005515,0005634,0005737,0005886,0006952,0009536,0009738,0010427,0038023,0042802,0042803,0062049,0080163 -logKd/Ki=5.94, IC50=1.14uM Q8VZS8 20554531 201 HHQTMPSDLTQDEFTQLSQSIAEFHTYQLGNGRCSSLLAQRIHAPPETVWSVVRRFDRPQIYKHFIKSCNVSEDFEMRVGCTRDVNVISGLPANTSRERLDLLDDDRRVTGFSITGGEHRLRNYKSVTTVHRFEKRIWTVVLESYVVDVPEGNSEEDTRLFADTVIRLNLQKLASITEAMNR 3neg A 2.801 BS01 PYV A 1 K65 I68 V87 A95 S98 E100 H121 Y126 K63 I66 V85 A93 S96 E98 H119 Y124 3.1.3.16 0004864,0005515,0005634,0005737,0005886,0006952,0009536,0009738,0010427,0038023,0042802,0042803,0062049,0080163 -logKd/Ki=5.94, IC50=1.14uM Q8VZS8 20554531 201 HHQTMPSDLTQDEFTQLSQSIAEFHTYQLGNGRCSSLLAQRIHAPPETVWSVVRRFDRPQIYKHFIKSCNVSEDFEMRVGCTRDVNVISGLPANTSRERLDLLDDDRRVTGFSITGGEHRLRNYKSVTTVHRFEKRIWTVVLESYVVDVPEGNSEEDTRLFADTVIRLNLQKLASITEAMNR 3neg B 2.801 BS01 PYV B 1 V89 S98 E100 F114 I116 L123 V172 V81 S90 E92 F106 I108 L115 V158 3.1.3.16 0004864,0005515,0005634,0005737,0005886,0006952,0009536,0009738,0010427,0038023,0042802,0042803,0062049,0080163 Q8VZS8 20554531 201 SDLTQDEFTQLSQSIAEFHTYQLGNGRCSSLLAQRIHAPPETVWSVVRRFDRPQIYKHFIKSCNVSEDFEMRVGCTRDVNVISGLPANTSRERLDLLDDDRRVTGFSITGGEHRLRNYKSVTTVHRFEKIWTVVLESYVVDVPEGNSEEDTRLFADTVIRLNLQKLASITEAMNRNN 3nj0 A 1.89 BS01 PYV A 1 K64 E98 Y124 F165 V169 K56 E90 Y115 F156 V160 ? 0004864,0005515,0005634,0005737,0005886,0009738,0010427,0038023,0042802,0042803,0062049 O80992 20729860 300 GLTDEEQKTLEPVIKTYHQFEPDPTTCTSLITQRIHAPASVVWPLIRRFDNPERYKHFVKRCRLISGDGDVGSVREVTVISGLPASTSTERLEFVDDDHRVLSFRVVGGHRLKNYKSVTSVNEFLNQDSGKVYTVVLESYTVDIPEGNTEEDTKMFVDTVVKLNLQKLGVAATSAPM 3nj0 B 1.89 BS01 PYV B 1 K64 V87 E98 Y124 V166 V169 K58 V81 E92 Y116 V158 V161 ? 0004864,0005515,0005634,0005737,0005886,0009738,0010427,0038023,0042802,0042803,0062049 O80992 20729860 300 VKGLTDEEQKTLEPVIKTYHQFEPDPTTCTSLITQRIHAPASVVWPLIRRFDNPERYKHFVKRCRLISGDGDVGSVREVTVISGLPASTSTERLEFVDDDHRVLSFRVVGHRLKNYKSVTSVNEFLNQDSGKVYTVVLESYTVDIPEGNTEEDTKMFVDTVVKLNLQKLGVAATSAPMH 3nj0 C 1.89 BS01 PYV C 1 K64 V87 Y124 F165 V169 K56 V79 Y114 F155 V159 ? 0004864,0005515,0005634,0005737,0005886,0009738,0010427,0038023,0042802,0042803,0062049 O80992 20729860 300 GLTDEEQKTLEPVIKTYHQFEPDPTTCTSLITQRIHAPASVVWPLIRRFDNPERYKHFVKRCRLISGDGDVGSVREVTVISGLPASTSTERLEFVDDDHRVLSFRVVGHRLKNYKSVTSVNEFLNQDSGKVYTVVLESYTVDIPEGNTEEDTKMFVDTVVKLNLQKLGVAATSAPMH 3nj1 A 1.948 BS01 PYV A 1 H65 V85 V87 E98 H119 Y124 V169 H58 V78 V80 E91 H112 Y117 V162 ? 0004864,0005515,0005634,0005737,0005886,0009738,0010427,0038023,0042802,0042803,0062049 O80992 20729860 300 KGLTDEEQKTLEPVIKTYHQFEPDPTTCTSLITQRIHAPASVVWPLIRRFDNPERYKHFVKRCRLISGDGDVGSVREVTVISGLPASTSTERLEFVDDDHRVLSFRIVGGEHRLKNYKSVTSVNEFLNQDSGKVYTVVLESYTVDIPEGNTEEDTKMFVDTVVKLNLQKLGVAATSAPMHDD 3njo A 2.473 BS01 PYV A 1 E94 Y120 V163 E89 Y115 V152 ? 0004864,0005515,0005634,0005737,0005773,0005829,0005886,0009705,0009738,0010427,0038023,0042802,0042803,0044389,0062049,0080163,1902584 O49686 20729860 300 TPEERSELKNSIAEFHTYQLDPGSCSSLHAQRIHAPPELVWSIVRRFDKPQTYKHFIKSCSVEQNFEMRVGCTRDVIVISGLSANTSTERLDILDDERRVTGFSIIGGEHRLTNYKSVTTVHRFEKENRIWTVVLESYVVDMPDTRMFADTVVKLNLQKLATVAEAMAR 3njo C 2.473 BS01 PYV C 1 V83 L87 E94 L117 F159 V163 V81 L85 E92 L115 F150 V154 ? 0004864,0005515,0005634,0005737,0005773,0005829,0005886,0009705,0009738,0010427,0038023,0042802,0042803,0044389,0062049,0080163,1902584 O49686 20729860 300 SELTPEERSELKNSIAEFHTYQLDPGSCSSLHAQRIHAPPELVWSIVRRFDKPQTYKHFIKSCSVEQNFEMRVGCTRDVIVISGLSANTSTERLDILDDERRVTGFSIIGGEHRLTNYKSVTTVHRFEKENRIWTVVLESYVVDMDTRMFADTVVKLNLQKLATVAEAMAR 3nmh A 1.85 BS01 PYV A 1 K64 F112 E118 Y124 V166 V169 K52 F100 E106 Y112 V154 V157 ? 0004864,0005515,0005634,0005737,0005886,0009738,0010427,0038023,0042802,0042803,0062049 O80992 20729862 900 SEQKTLEPVIKTYHQFEPDPTTCTSLITQRIHAPASVVWPLIRRFDNPERYKHFVKRCRLISGDGDVGSVREVTVISGLPASTSTERLEFVDDDHRVLSFRVVGGEHRLKNYKSVTSVNEFLNQDSGKVYTVVLESYTVDIPEGNTEEDTKMFVDTVVKLNLQKLGVAATSAPMHD 3nmh B 1.85 BS01 PYV B 1 K64 E98 Y124 V169 K52 E86 Y112 V157 ? 0004864,0005515,0005634,0005737,0005886,0009738,0010427,0038023,0042802,0042803,0062049 O80992 20729862 900 SEQKTLEPVIKTYHQFEPDPTTCTSLITQRIHAPASVVWPLIRRFDNPERYKHFVKRCRLISGDGDVGSVREVTVISGLPASTSTERLEFVDDDHRVLSFRVVGGEHRLKNYKSVTSVNEFLNQDSGKVYTVVLESYTVDIPEGNTEEDTKMFVDTVVKLNLQKLGVAATSAPMHD 3nmh C 1.85 BS01 PYV C 1 K64 V87 E118 Y124 V169 K52 V75 E106 Y112 V157 ? 0004864,0005515,0005634,0005737,0005886,0009738,0010427,0038023,0042802,0042803,0062049 O80992 20729862 900 SEQKTLEPVIKTYHQFEPDPTTCTSLITQRIHAPASVVWPLIRRFDNPERYKHFVKRCRLISGDGDVGSVREVTVISGLPASTSTERLEFVDDDHRVLSFRVVGGEHRLKNYKSVTSVNEFLNQDSGKVYTVVLESYTVDIPEGNTEEDTKMFVDTVVKLNLQKLGVAATSAPMHDD 3nmn A 2.15 BS01 PYV A 1 A116 E121 H142 L144 Y147 F189 V193 A82 E87 H108 L110 Y113 F148 V152 ? Q8VZS8 20729862 900 SEFTQLSQSIAEFHTYQLGNGRCSSLLAQRIHAPPETVWSVVRRFDRPQIYKHFIKSCNVSEDFEMRVGCTRDVNVISGLPANTSRERLDLLDDDRRVTGFSITGGEHRLRNYKSVTTVHRFEIWTVVLESYVVDVPEGNSEEDTRLFADTVIRLNLQKLASITEAMN 3nmn C 2.15 BS01 PYV C 1 A116 S119 E121 L144 Y147 F189 A82 S85 E87 L110 Y113 F149 ? Q8VZS8 20729862 900 SEFTQLSQSIAEFHTYQLGNGRCSSLLAQRIHAPPETVWSVVRRFDRPQIYKHFIKSCNVSEDFEMRVGCTRDVNVISGLPANTSRERLDLLDDDRRVTGFSITGGEHRLRNYKSVTTVHRFERIWTVVLESYVVDVPEGNSEEDTRLFADTVIRLNLQKLASITEAMNRN 3nmp A 2.1 BS01 PYV A 1 V87 E98 F112 L121 V169 V75 E86 F100 L109 V157 ? 0004864,0005515,0005634,0005737,0005886,0009738,0010427,0038023,0042802,0042803,0062049 O80992 20729862 900 SEQKTLEPVIKTYHQFEPDPTTCTSLITQRIHAPASVVWPLIRRFDNPERYKHFVKRCRLISGDGDVGSVREVTVISGLPFSTSTERLEFVDDDHRVLSFRVVGGEHRLKNYKSVTSVNEFLNQDSGKVYTVVLESYTVDIPEGNTEEDTKMFVDTVVKLNLQKLGVAATSAPMHD 3nmp B 2.1 BS01 PYV B 1 K64 H65 E98 F112 L121 Y124 V169 K52 H53 E86 F100 L109 Y112 V157 ? 0004864,0005515,0005634,0005737,0005886,0009738,0010427,0038023,0042802,0042803,0062049 O80992 20729862 900 SEQKTLEPVIKTYHQFEPDPTTCTSLITQRIHAPASVVWPLIRRFDNPERYKHFVKRCRLISGDGDVGSVREVTVISGLPFSTSTERLEFVDDDHRVLSFRVVGGEHRLKNYKSVTSVNEFLNQDSGKVYTVVLESYTVDIPEGNTEEDTKMFVDTVVKLNLQKLGVAATSAPMHD 3nmp C 2.1 BS01 PYV C 1 K64 V87 E98 V114 L121 Y124 V169 K52 V75 E86 V102 L109 Y112 V157 ? 0004864,0005515,0005634,0005737,0005886,0009738,0010427,0038023,0042802,0042803,0062049 O80992 20729862 900 SEQKTLEPVIKTYHQFEPDPTTCTSLITQRIHAPASVVWPLIRRFDNPERYKHFVKRCRLISGDGDVGSVREVTVISGLPFSTSTERLEFVDDDHRVLSFRVVGGEHRLKNYKSVTSVNEFLNQDSGKVYTVVLESYTVDIPEGNTEEDTKMFVDTVVKLNLQKLGVAATSAPMHD 3nmt A 2.56 BS01 PYV A 1 K64 F93 E98 F112 L121 Y124 K52 F81 E86 F100 L109 Y112 ? 0004864,0005515,0005634,0005737,0005886,0009738,0010427,0038023,0042802,0042803,0062049 O80992 20729862 900 SEQKTLEPVIKTYHQFEPDPTTCTSLITQRIHAPASVVWPLIRRFDNPERYKHFVKRCRLISGDGDVGSVREVTVISGLPFSTSTERLEFVDDDHRVLSFRVVGGEHRLKNYKSVTSVNEFLNQDSGKVYTVVLESYTVDIPEGNTEEDTKMFVDTVVKLNLQKLGVAATSAPMHD 3nmv A 2.1 BS01 PYV A 1 F93 S96 E98 F112 L121 Y124 F165 V169 F81 S84 E86 F100 L109 Y112 F153 V157 ? 0004864,0005515,0005634,0005737,0005886,0009738,0010427,0038023,0042802,0042803,0062049 O80992 20729862 900 SEQKTLEPVIKTYHQFEPDPTTCTSLITQRIHAPASVVWPLIRRFDNPERYKHFVKRCRLISGDGDVGSVREVTVISGLPFSTSTERLEFVDDDHRVLSFRVVGGEHRLKNYKSVTSVNEFLNQDSGKVYTVVLESYTVDIPEGNTEEDTKMFVDTVVKLNLQKLGVAATSAPMHD 3nr4 A 2.006 BS01 PYV A 1 K64 V87 E98 Y124 F165 V169 K57 V80 E91 Y117 F158 V162 ? 0004864,0005515,0005634,0005737,0005886,0009738,0010427,0038023,0042802,0042803,0062049 O80992 20630864 191 KGLTDEEQKTLEPVIKTYHQFEPDPTTCTSLITQRIHAPASVVWPLIRRFDNPERYKHFVKRCRLISGDGDVGSVREVTVISGLPASTSTERLEFVDDDHRVLSFRVVGGEHRLKNYKSVTSVNEFLNQDSGKVYTVVLESYTVDIPEGNTEEDTKMFVDTVVKLNLQKLGVAATSAPMHD 3nr4 B 2.006 BS01 PYV B 1 V87 E98 Y124 F165 V169 V79 E90 Y113 F153 V157 ? 0004864,0005515,0005634,0005737,0005886,0009738,0010427,0038023,0042802,0042803,0062049 O80992 20630864 191 GLTDEEQKTLEPVIKTYHQFEPDPTTCTSLITQRIHAPASVVWPLIRRFDNPERYKHFVKRCRLISGDGDVGSVREVTVISGLPASTSTERLEFVDDDHRVLSFRVVGRLKNYKSVTSVNEFLNQSGKVYTVVLESYTVDIPEGNTEEDTKMFVDTVVKLNLQKLGVAATSAPMH 3nr4 C 2.006 BS01 PYV C 1 V87 E98 Y124 F165 V169 V79 E90 Y116 F153 V157 ? 0004864,0005515,0005634,0005737,0005886,0009738,0010427,0038023,0042802,0042803,0062049 O80992 20630864 191 GLTDEEQKTLEPVIKTYHQFEPDPTTCTSLITQRIHAPASVVWPLIRRFDNPERYKHFVKRCRLISGDGDVGSVREVTVISGLPASTSTERLEFVDDDHRVLSFRVVGGEHRLKNYKSVTSVNEFLNKVYTVVLESYTVDIPEGNTEEDTKMFVDTVVKLNLQKLGVAATSAPMH 3ns2 A 1.634 BS01 PYV A 1 K64 V87 E98 Y124 F165 V169 K57 V80 E91 Y117 F158 V162 ? 0004864,0005515,0005634,0005737,0005886,0009738,0010427,0038023,0042802,0042803,0062049 O80992 20630864 191 KGLTDEEQKTLEPVIKTYHQFEPDPTTCTSLITQRIHAPASVVWPLIRRFDNPERYKHFVKRCRLISGDGDVGSVREVTVISGLPASTSTERLEFVDDDHRVLSFRVVGGEHRLKNYKSVTSVNEFLNQDSGKVYTVVLESYTVDIPEGNTEEDTKMFVDTVVKLNLQKLGVAATSAPMHD 3ns2 B 1.634 BS01 PYV B 1 K64 V87 E98 Y124 F165 V169 K57 V80 E91 Y117 F158 V162 ? 0004864,0005515,0005634,0005737,0005886,0009738,0010427,0038023,0042802,0042803,0062049 O80992 20630864 191 KGLTDEEQKTLEPVIKTYHQFEPDPTTCTSLITQRIHAPASVVWPLIRRFDNPERYKHFVKRCRLISGDGDVGSVREVTVISGLPASTSTERLEFVDDDHRVLSFRVVGGEHRLKNYKSVTSVNEFLNQDSGKVYTVVLESYTVDIPEGNTEEDTKMFVDTVVKLNLQKLGVAATSAPM 3ns2 C 1.634 BS01 PYV C 1 K64 V87 E98 Y124 F165 V169 K57 V80 E91 Y117 F158 V162 ? 0004864,0005515,0005634,0005737,0005886,0009738,0010427,0038023,0042802,0042803,0062049 O80992 20630864 191 KGLTDEEQKTLEPVIKTYHQFEPDPTTCTSLITQRIHAPASVVWPLIRRFDNPERYKHFVKRCRLISGDGDVGSVREVTVISGLPASTSTERLEFVDDDHRVLSFRVVGGEHRLKNYKSVTSVNEFLNQDSGKVYTVVLESYTVDIPEGNTEEDTKMFVDTVVKLNLQKLGVAATSAPMHD 3oji A 1.84 BS01 PYV A 1 A113 S116 Y144 V192 A88 S91 Y119 V167 ? 0004864,0005515,0005634,0005737,0005886,0009738,0010427,0038023,0042802,0042803,0062049 Q9SSM7 22579247 210 TPYGLTKDEFSTLDSIIRTHHTFPRSNTCTSLIAHRVDAPAHAIWRFVRDFANPNKYKHFIKSCTIRVNKEIKVGTIREVSVVSGLPASTSVEILEVLDEEKRILSFRVLGGEHRLNNYRSVTSVNEFVVLEKDKKKRVYSVVLESYIVDIPQGNTEEDTRMFVDTVVKSNLQNLAVISTA 3oji B 1.84 BS01 PYV B 1 A113 Y144 V192 A89 Y120 V168 ? 0004864,0005515,0005634,0005737,0005886,0009738,0010427,0038023,0042802,0042803,0062049 Q9SSM7 22579247 210 TPYGLTKDEFSTLDSIIRTHHTFPRSPNTCTSLIAHRVDAPAHAIWRFVRDFANPNKYKHFIKSCTIRGIKEIKVGTIREVSVVSGLPASTSVEILEVLDEEKRILSFRVLGGEHRLNNYRSVTSVNEFVVLEKDKKKRVYSVVLESYIVDIPQGNTEEDTRMFVDTVVKSNLQNLAVISTASPT 5ur4 A 1.52 BS01 PYV A 1 A89 S92 E94 I110 H115 L117 Y120 F159 V163 A89 S92 E94 I110 H115 L117 Y120 F150 V154 ? 0004864,0005515,0005634,0005737,0005773,0005829,0005886,0009705,0009738,0010427,0038023,0042802,0042803,0044389,0062049,0080163,1902584 O49686 201 MPSELTPEERSELKNSIAEFHTYQLDPGSCSSLHAQRIHAPPELVWSIVRRFDKPQTYKHFIKSCSVEQNFEMRVGCTRDVIVISGLPANTSTERLDILDDERRVTGFSIIGGEHRLTNYKSVTTVHRFEKENRIWTVVLESYVVDMRMFADTVVKLNLQKLATVAEAMARN 5zcu C 2.413 BS01 PYV C 1 K76 F78 S107 E109 F125 H130 L132 Y135 L178 N182 K43 F45 S74 E76 F92 H97 L99 Y102 L145 N149 ? ic50=2160nM -logKd/Ki=5.67, IC50=2160nM Q6EN42 30941543 301 VRRFHRHEPRDHQCSSAVAKHIKAPVHLVWSLVRRFDQPQLFKPFVSRCEMKGNIEIGSVREVNVKSGLPATRSTERLELLDDNEHILSVRFVGGDHRLKNYSSILTVHPEVIDGRPGTLVIESFVVDVPEGNTKDETCYFVEALLKCNLKSLAEVSERLVV 5zcu D 2.413 BS01 PYV D 1 F78 S107 F125 H130 L132 Y135 L178 N182 F45 S74 F92 H97 L99 Y102 L145 N149 ? ic50=2160nM Q6EN42 30941543 301 VRRFHRHEPRDHQCSSAVAKHIKAPVHLVWSLVRRFDQPQLFKPFVSRCEMKGNIEIGSVREVNVKSGLPATRSTERLELLDDNEHILSVRFVGGDHRLKNYSSILTVHPEVIDGRPGTLVIESFVVDVPEGNTKDETCYFVEALLKCNLKSLAEVSERLVV