1b9i A 2.0 BS01 PXG A 1 N61 G62 T63 F88 S90 D159 A161 H162 S183 Q185 K188 N57 G58 T59 F84 S86 D155 A157 H158 S179 Q181 K184 F88 D159 H162 Q185 K188 R219 Y226 R236 F84 D155 H158 Q181 K184 R215 Y222 R232 2.6.1.-,4.2.1.144 0000271,0008483,0016740,0016829,0017000,0030170 O52552 10433690 389 KAPEFPAWPQYDDAERNGLVRALEQGQWWRMGGDEVNSFEREFAAHHGAAHALAVTNGTHALELALQVMGVGPGTEVIVPAFTFISSSQAAQRLGAVTVPVDVDAATYNLDPEAVAAAVTPRTKVIMPVHMAGLMADMDALAKISADTGVPLLQDAAHAHGARWQGKRVGELDSIATFSFQNGKLMTAGEGGAVVFPDGETEKYETAFLRHSCGRPRDDRRYFHKIAGSNMRLNEFSASVLRAQLARLDEQIAVRDERWTLLSRLLGAIDGVVPQGGDVRADRNSHYMAMFRIPGLTEERRNALVDRLVEAGLPAFAAFRAIYRTDAFWELGAPDESVDAIARRCPNTDAISSDCVWLHHRVLLAGEPELHATAEIIADAVGRA 3fq7 A 2.15 BS01 PXG A 1 S1029 V1031 W1067 G1123 T1124 Y1150 H1151 E1212 N1217 D1245 V1247 M1248 K1273 E1406 S23 V25 W61 G117 T118 Y144 H145 E206 N211 D239 V241 M242 K267 E400 V1027 Y1150 D1245 M1248 K1273 A1407 V21 Y144 D239 M242 K267 A401 5.4.3.8 0005737,0006782,0008483,0015995,0016853,0030170,0033014,0042286 -logKd/Ki=2.52, IC50=3mM P24630 19786580 1434 FKTIKSDEIFAAAQKLMPGGVSSPVRAFKSVGGQPIVFDRVKDAYAWDVDGNRYIDYVGTWGPAICGHAHPEVIEALKVAMEKGTSFGAPCALENVLAEMVNDAVPSIEMVRFVNSGTEACMAVLRIMRAYTGRDKIIKFEGCYHGHADMFLVKAGSGVATLGLPSSPGVPKKTTANTLTTPYNDLEAVKALFAENPGEIAGVILEPIVGNSGFIVPDAGFLEGLREITLEHDALLVFDEVMTGFRIAYGGVQEKFGVTPDLTTLGKIIGGGLPVGAYGGKREIMQLVAPAGPMYQAGTLSGNPLAMTAGIKTLELLRQPGTYEYLDQITKRLSDGLLAIAQETGHAACGGQVSGMFGFFFTEGPVHNYEDAKKSDLQKFSRFHRGMLEQGIYLAPSQFEAGFTSLAHTEEDIDATLAAARTVMSAL 3fq7 A 2.15 BS02 PXG B 1 G1304 T1305 G298 T299 V1027 Y1150 D1245 M1248 K1273 A1407 V21 Y144 D239 M242 K267 A401 5.4.3.8 0005737,0006782,0008483,0015995,0016853,0030170,0033014,0042286 -logKd/Ki=2.52, IC50=3mM P24630 19786580 2434 FKTIKSDEIFAAAQKLMPGGVSSPVRAFKSVGGQPIVFDRVKDAYAWDVDGNRYIDYVGTWGPAICGHAHPEVIEALKVAMEKGTSFGAPCALENVLAEMVNDAVPSIEMVRFVNSGTEACMAVLRIMRAYTGRDKIIKFEGCYHGHADMFLVKAGSGVATLGLPSSPGVPKKTTANTLTTPYNDLEAVKALFAENPGEIAGVILEPIVGNSGFIVPDAGFLEGLREITLEHDALLVFDEVMTGFRIAYGGVQEKFGVTPDLTTLGKIIGGGLPVGAYGGKREIMQLVAPAGPMYQAGTLSGNPLAMTAGIKTLELLRQPGTYEYLDQITKRLSDGLLAIAQETGHAACGGQVSGMFGFFFTEGPVHNYEDAKKSDLQKFSRFHRGMLEQGIYLAPSQFEAGFTSLAHTEEDIDATLAAARTVMSAL 3fq7 B 2.15 BS01 PXG A 1 A2303 G2304 T2305 A297 G298 T299 V2027 Y2150 E2212 D2245 M2248 K2273 A2407 V21 Y144 E206 D239 M242 K267 A401 5.4.3.8 0005737,0006782,0008483,0015995,0016853,0030170,0033014,0042286 -logKd/Ki=2.52, IC50=3mM P24630 19786580 1434 FKTIKSDEIFAAAQKLMPGGVSSPVRAFKSVGGQPIVFDRVKDAYAWDVDGNRYIDYVGTWGPAICGHAHPEVIEALKVAMEKGTSFGAPCALENVLAEMVNDAVPSIEMVRFVNSGTEACMAVLRIMRAYTGRDKIIKFEGCYHGHADMFLVKAGSGVATLGLPSSPGVPKKTTANTLTTPYNDLEAVKALFAENPGEIAGVILEPIVGNSGFIVPDAGFLEGLREITLEHDALLVFDEVMTGFRIAYGGVQEKFGVTPDLTTLGKIIGGGLPVGAYGGKREIMQLVAPAGPMYQAGTLSGNPLAMTAGIKTLELLRQPGTYEYLDQITKRLSDGLLAIAQETGHAACGGQVSGMFGFFFTEGPVHNYEDAKKSDLQKFSRFHRGMLEQGIYLAPSQFEAGFTSLAHTEEDIDATLAAARTVMSAL 3fq7 B 2.15 BS02 PXG B 1 S2029 V2031 W2067 S2122 G2123 T2124 Y2150 H2151 E2212 N2217 D2245 V2247 M2248 K2273 E2406 S23 V25 W61 S116 G117 T118 Y144 H145 E206 N211 D239 V241 M242 K267 E400 V2027 Y2150 E2212 D2245 M2248 K2273 A2407 V21 Y144 E206 D239 M242 K267 A401 5.4.3.8 0005737,0006782,0008483,0015995,0016853,0030170,0033014,0042286 -logKd/Ki=2.52, IC50=3mM P24630 19786580 2434 FKTIKSDEIFAAAQKLMPGGVSSPVRAFKSVGGQPIVFDRVKDAYAWDVDGNRYIDYVGTWGPAICGHAHPEVIEALKVAMEKGTSFGAPCALENVLAEMVNDAVPSIEMVRFVNSGTEACMAVLRIMRAYTGRDKIIKFEGCYHGHADMFLVKAGSGVATLGLPSSPGVPKKTTANTLTTPYNDLEAVKALFAENPGEIAGVILEPIVGNSGFIVPDAGFLEGLREITLEHDALLVFDEVMTGFRIAYGGVQEKFGVTPDLTTLGKIIGGGLPVGAYGGKREIMQLVAPAGPMYQAGTLSGNPLAMTAGIKTLELLRQPGTYEYLDQITKRLSDGLLAIAQETGHAACGGQVSGMFGFFFTEGPVHNYEDAKKSDLQKFSRFHRGMLEQGIYLAPSQFEAGFTSLAHTEEDIDATLAAARTVMSAL 3zrr A 1.99 BS01 PXG A 1 V8 G62 G63 T64 F88 T138 D163 V165 R337 V4 G58 G59 T60 F84 T134 D159 V161 R333 2.6.1.51 0004760,0005777,0008453,0008483,0019265,0046872 Q97VM5 22751661 470 LLHVGPTTIKEDVLVAGLENNVGFTSKEFVEALAYSLKGLRYVMGASKNYQPLIIPGGGTSAMESVTSLLKPNDKILVVSNGVFGDRWEQIFKRYPVNVKVLRPSPGDYVKPGEVEEEVRKSEYKLVALTHVETSTGVREPVKDVINKIRKYVELIVVDGVSSVGAEEVKAEEWNVDVYLTASQKALGSAAGLGLLLLSPKALSILDSQNSIAGYYLDLRNWLPVMRGAEEGKAAYFATPPVHVILQLAEAFRLIEKEGIENRIKRHTMVASAIRAGLEALGLEIVARRPESYSNTVTGVILKVADPQKVLAGTVNEGVEFAPGVHPAFKYFRIGHMGWVTPNDAIIAISVIERTLRKLGEPIRFGEGVKAVEEVLFSA 3zrr A 1.99 BS02 PXG B 1 F28 Y240 T243 F24 Y236 T239 2.6.1.51 0004760,0005777,0008453,0008483,0019265,0046872 Q97VM5 22751661 470 LLHVGPTTIKEDVLVAGLENNVGFTSKEFVEALAYSLKGLRYVMGASKNYQPLIIPGGGTSAMESVTSLLKPNDKILVVSNGVFGDRWEQIFKRYPVNVKVLRPSPGDYVKPGEVEEEVRKSEYKLVALTHVETSTGVREPVKDVINKIRKYVELIVVDGVSSVGAEEVKAEEWNVDVYLTASQKALGSAAGLGLLLLSPKALSILDSQNSIAGYYLDLRNWLPVMRGAEEGKAAYFATPPVHVILQLAEAFRLIEKEGIENRIKRHTMVASAIRAGLEALGLEIVARRPESYSNTVTGVILKVADPQKVLAGTVNEGVEFAPGVHPAFKYFRIGHMGWVTPNDAIIAISVIERTLRKLGEPIRFGEGVKAVEEVLFSA 3zrr B 1.99 BS01 PXG A 1 F28 Y240 T243 F24 Y236 T239 2.6.1.51 0004760,0005777,0008453,0008483,0019265,0046872 Q97VM5 22751661 470 LLHVGPTTIKEDVLVAGLENNVGFTSKEFVEALAYSLKGLRYVMGASKNYQPLIIPGGGTSAMESVTSLLKPNDKILVVSNGVFGDRWEQIFKRYPVNVKVLRPSPGDYVKPGEVEEEVRKSEYKLVALTHVETSTGVREPVKDVINKIRKYVELIVVDGVSSVGAEEVKAEEWNVDVYLTASQKALGSAAGLGLLLLSPKALSILDSQNSIAGYYLDLRNWLPVMRGAEEGKAAYFATPPVHVILQLAEAFRLIEKEGIENRIKRHTMVASAIRAGLEALGLEIVARRPESYSNTVTGVILKVADPQKVLAGTVNEGVEFAPGVHPAFKYFRIGHMGWVTPNDAIIAISVIERTLRKLGEPIRFGEGVKAVEEVLFSA 3zrr B 1.99 BS02 PXG B 1 V8 G62 G63 T64 F88 T138 D163 V165 R337 V4 G58 G59 T60 F84 T134 D159 V161 R333 2.6.1.51 0004760,0005777,0008453,0008483,0019265,0046872 Q97VM5 22751661 470 LLHVGPTTIKEDVLVAGLENNVGFTSKEFVEALAYSLKGLRYVMGASKNYQPLIIPGGGTSAMESVTSLLKPNDKILVVSNGVFGDRWEQIFKRYPVNVKVLRPSPGDYVKPGEVEEEVRKSEYKLVALTHVETSTGVREPVKDVINKIRKYVELIVVDGVSSVGAEEVKAEEWNVDVYLTASQKALGSAAGLGLLLLSPKALSILDSQNSIAGYYLDLRNWLPVMRGAEEGKAAYFATPPVHVILQLAEAFRLIEKEGIENRIKRHTMVASAIRAGLEALGLEIVARRPESYSNTVTGVILKVADPQKVLAGTVNEGVEFAPGVHPAFKYFRIGHMGWVTPNDAIIAISVIERTLRKLGEPIRFGEGVKAVEEVLFSA 4b98 A 1.65 BS01 PXG A 1 L60 W61 S119 G120 S121 Y153 H154 G155 E226 S231 D259 V261 I262 K288 R414 Q421 L53 W54 S112 G113 S114 Y146 H147 G148 E219 S224 D252 V254 I255 K281 R407 Q414 F24 Y153 E226 D259 I262 K288 Q421 F17 Y146 E219 D252 I255 K281 Q414 2.6.1.18 0004015,0008483,0009102,0016223,0019483,0030170 Q9I700 23519665 470 APPVSSELNLRAHWMPFSANRNFQKDPRIIVAAEGSWLTDDKGRKVYDSLSGLWTCGAGHSRKEIQEAVARQLGTLDYSPGFQYGHPLSFQLAEKIAGLLPGELNHVFFTGSGSECADTSIKMARAYWRLKGQPQKTKLIGRARGYHGVNVAGTSLGGIGGNRKMFGQLMDVDHLPHTLQPGMAFTRGMAQTGGVELANELLKLIELHDASNIAAVIVEPMSGSAGVLVPPVGYLQRLREICDQHNILLIFDEVITAFGRLGTYSGAEYFGVTPDLMNVAKQVTNGAVPMGAVIASSEIYDTFMNQALPEHAVEFSHGYTYSAHPVACAAGLAALDILARDNLVQQSAELAPHFEKGLHGLQGAKNVIDIRNCGLAGAIQIAPRDGDPTVRPFEAGMKLWQQGFYVRFGGDTLQFGPTFNARPEELDRLFDAVGEALNGIA 4b98 A 1.65 BS03 PXG B 1 F89 Y326 T327 F82 Y319 T320 F24 Y153 E226 D259 I262 K288 Q421 F17 Y146 E219 D252 I255 K281 Q414 2.6.1.18 0004015,0008483,0009102,0016223,0019483,0030170 Q9I700 23519665 470 APPVSSELNLRAHWMPFSANRNFQKDPRIIVAAEGSWLTDDKGRKVYDSLSGLWTCGAGHSRKEIQEAVARQLGTLDYSPGFQYGHPLSFQLAEKIAGLLPGELNHVFFTGSGSECADTSIKMARAYWRLKGQPQKTKLIGRARGYHGVNVAGTSLGGIGGNRKMFGQLMDVDHLPHTLQPGMAFTRGMAQTGGVELANELLKLIELHDASNIAAVIVEPMSGSAGVLVPPVGYLQRLREICDQHNILLIFDEVITAFGRLGTYSGAEYFGVTPDLMNVAKQVTNGAVPMGAVIASSEIYDTFMNQALPEHAVEFSHGYTYSAHPVACAAGLAALDILARDNLVQQSAELAPHFEKGLHGLQGAKNVIDIRNCGLAGAIQIAPRDGDPTVRPFEAGMKLWQQGFYVRFGGDTLQFGPTFNARPEELDRLFDAVGEALNGIA 4b98 B 1.65 BS01 PXG A 1 F89 T327 F81 T319 F24 Y153 E226 D259 I262 K288 Q421 F16 Y145 E218 D251 I254 K280 Q413 2.6.1.18 0004015,0008483,0009102,0016223,0019483,0030170 Q9I700 23519665 470 PPVSSELNLRAHWMPFSANRNFQKDPRIIVAAEGSWLTDDKGRKVYDSLSGLWTCGAGHSRKEIQEAVARQLGTLDYSPGFQYGHPLSFQLAEKIAGLLPGELNHVFFTGSGSECADTSIKMARAYWRLKGQPQKTKLIGRARGYHGVNVAGTSLGGIGGNRKMFGQLMDVDHLPHTLQPGMAFTRGMAQTGGVELANELLKLIELHDASNIAAVIVEPMSGSAGVLVPPVGYLQRLREICDQHNILLIFDEVITAFGRLGTYSGAEYFGVTPDLMNVAKQVTNGAVPMGAVIASSEIYDTFMNQALPEHAVEFSHGYTYSAHPVACAAGLAALDILARDNLVQQSAELAPHFEKGLHGLQGAKNVIDIRNCGLAGAIQIAPRDGDPTVRPFEAGMKLWQQGFYVRFGGDTLQFGPTFNARPEELDRLFDAVGEALNGIA 4b98 B 1.65 BS02 PXG B 1 W61 S119 G120 S121 Y153 H154 G155 E226 S231 D259 V261 I262 K288 R414 Q421 W53 S111 G112 S113 Y145 H146 G147 E218 S223 D251 V253 I254 K280 R406 Q413 F24 Y153 E226 D259 I262 K288 Q421 F16 Y145 E218 D251 I254 K280 Q413 2.6.1.18 0004015,0008483,0009102,0016223,0019483,0030170 Q9I700 23519665 470 PPVSSELNLRAHWMPFSANRNFQKDPRIIVAAEGSWLTDDKGRKVYDSLSGLWTCGAGHSRKEIQEAVARQLGTLDYSPGFQYGHPLSFQLAEKIAGLLPGELNHVFFTGSGSECADTSIKMARAYWRLKGQPQKTKLIGRARGYHGVNVAGTSLGGIGGNRKMFGQLMDVDHLPHTLQPGMAFTRGMAQTGGVELANELLKLIELHDASNIAAVIVEPMSGSAGVLVPPVGYLQRLREICDQHNILLIFDEVITAFGRLGTYSGAEYFGVTPDLMNVAKQVTNGAVPMGAVIASSEIYDTFMNQALPEHAVEFSHGYTYSAHPVACAAGLAALDILARDNLVQQSAELAPHFEKGLHGLQGAKNVIDIRNCGLAGAIQIAPRDGDPTVRPFEAGMKLWQQGFYVRFGGDTLQFGPTFNARPEELDRLFDAVGEALNGIA 4b98 C 1.65 BS01 PXG C 1 W61 S119 G120 S121 Y153 H154 G155 S231 D259 V261 I262 K288 R414 Q421 W54 S112 G113 S114 Y146 H147 G148 S224 D252 V254 I255 K281 R407 Q414 F24 Y153 E226 D259 I262 K288 Q421 F17 Y146 E219 D252 I255 K281 Q414 2.6.1.18 0004015,0008483,0009102,0016223,0019483,0030170 Q9I700 23519665 470 APPVSSELNLRAHWMPFSANRNFQKDPRIIVAAEGSWLTDDKGRKVYDSLSGLWTCGAGHSRKEIQEAVARQLGTLDYSPGFQYGHPLSFQLAEKIAGLLPGELNHVFFTGSGSECADTSIKMARAYWRLKGQPQKTKLIGRARGYHGVNVAGTSLGGIGGNRKMFGQLMDVDHLPHTLQPGMAFTRGMAQTGGVELANELLKLIELHDASNIAAVIVEPMSGSAGVLVPPVGYLQRLREICDQHNILLIFDEVITAFGRLGTYSGAEYFGVTPDLMNVAKQVTNGAVPMGAVIASSEIYDTFMNQALPEHAVEFSHGYTYSAHPVACAAGLAALDILARDNLVQQSAELAPHFEKGLHGLQGAKNVIDIRNCGLAGAIQIAPRDGDPTVRPFEAGMKLWQQGFYVRFGGDTLQFGPTFNARPEELDRLFDAVGEALNGIA 4b98 C 1.65 BS03 PXG D 1 F89 Y326 T327 F82 Y319 T320 F24 Y153 E226 D259 I262 K288 Q421 F17 Y146 E219 D252 I255 K281 Q414 2.6.1.18 0004015,0008483,0009102,0016223,0019483,0030170 Q9I700 23519665 470 APPVSSELNLRAHWMPFSANRNFQKDPRIIVAAEGSWLTDDKGRKVYDSLSGLWTCGAGHSRKEIQEAVARQLGTLDYSPGFQYGHPLSFQLAEKIAGLLPGELNHVFFTGSGSECADTSIKMARAYWRLKGQPQKTKLIGRARGYHGVNVAGTSLGGIGGNRKMFGQLMDVDHLPHTLQPGMAFTRGMAQTGGVELANELLKLIELHDASNIAAVIVEPMSGSAGVLVPPVGYLQRLREICDQHNILLIFDEVITAFGRLGTYSGAEYFGVTPDLMNVAKQVTNGAVPMGAVIASSEIYDTFMNQALPEHAVEFSHGYTYSAHPVACAAGLAALDILARDNLVQQSAELAPHFEKGLHGLQGAKNVIDIRNCGLAGAIQIAPRDGDPTVRPFEAGMKLWQQGFYVRFGGDTLQFGPTFNARPEELDRLFDAVGEALNGIA 4b98 D 1.65 BS01 PXG C 1 Y326 T327 Y319 T320 F24 Y153 E226 D259 I262 K288 Q421 F17 Y146 E219 D252 I255 K281 Q414 2.6.1.18 0004015,0008483,0009102,0016223,0019483,0030170 Q9I700 23519665 470 APPVSSELNLRAHWMPFSANRNFQKDPRIIVAAEGSWLTDDKGRKVYDSLSGLWTCGAGHSRKEIQEAVARQLGTLDYSPGFQYGHPLSFQLAEKIAGLLPGELNHVFFTGSGSECADTSIKMARAYWRLKGQPQKTKLIGRARGYHGVNVAGTSLGGIGGNRKMFGQLMDVDHLPHTLQPGMAFTRGMAQTGGVELANELLKLIELHDASNIAAVIVEPMSGSAGVLVPPVGYLQRLREICDQHNILLIFDEVITAFGRLGTYSGAEYFGVTPDLMNVAKQVTNGAVPMGAVIASSEIYDTFMNQALPEHAVEFSHGYTYSAHPVACAAGLAALDILARDNLVQQSAELAPHFEKGLHGLQGAKNVIDIRNCGLAGAIQIAPRDGDPTVRPFEAGMKLWQQGFYVRFGGDTLQFGPTFNARPEELDRLFDAVGEALNGIA 4b98 D 1.65 BS02 PXG D 1 W61 S119 G120 S121 Y153 H154 G155 S231 D259 V261 I262 K288 R414 Q421 W54 S112 G113 S114 Y146 H147 G148 S224 D252 V254 I255 K281 R407 Q414 F24 Y153 E226 D259 I262 K288 Q421 F17 Y146 E219 D252 I255 K281 Q414 2.6.1.18 0004015,0008483,0009102,0016223,0019483,0030170 Q9I700 23519665 470 APPVSSELNLRAHWMPFSANRNFQKDPRIIVAAEGSWLTDDKGRKVYDSLSGLWTCGAGHSRKEIQEAVARQLGTLDYSPGFQYGHPLSFQLAEKIAGLLPGELNHVFFTGSGSECADTSIKMARAYWRLKGQPQKTKLIGRARGYHGVNVAGTSLGGIGGNRKMFGQLMDVDHLPHTLQPGMAFTRGMAQTGGVELANELLKLIELHDASNIAAVIVEPMSGSAGVLVPPVGYLQRLREICDQHNILLIFDEVITAFGRLGTYSGAEYFGVTPDLMNVAKQVTNGAVPMGAVIASSEIYDTFMNQALPEHAVEFSHGYTYSAHPVACAAGLAALDILARDNLVQQSAELAPHFEKGLHGLQGAKNVIDIRNCGLAGAIQIAPRDGDPTVRPFEAGMKLWQQGFYVRFGGDTLQFGPTFNARPEELDRLFDAVGEALNGIA 4ba5 A 1.76 BS01 PXG A 1 L59 W60 G120 S121 Y153 H154 G155 E226 A231 D259 V261 R416 L27 W28 G88 S89 Y121 H122 G123 E194 A199 D227 V229 R384 Y153 E226 D259 I262 K288 V423 Y121 E194 D227 I230 K256 V391 2.6.1.18 0004015,0005829,0008483,0030170,0042802 Q7NWG4 23519665 470 ARVMTRGEGVYLWDSEGNKIIDGMAGLWCVNVGYGRKDFAEAARRQMEELPFYNTFFKTTHPAVVELSSLLAEVTPAGFDRVFYTNSGSESVDTMIRMVRRYWDVQGKPEKKTLIGRWNGYHGSTIGGASLGGMKYMHEQGDLPIPGMAHIEQPWWYKHGKDMTPDEFGVVAARWLEEKILEIGADKVAAFVGEPIQGAGGVIVPPATYWPEIERICRKYDVLLVADEVICGFGRTGEWFGHQHFGFQPDLFTAAKGLSSGYLPIGAVFVGKRVAEGLIAGGDFNHGFTYSGHPVCAAVAHANVAALRDEGIVQRVKDDIGPYMQKRWRETFSRFEHVDDVRGVGMVQAFTLVKNKAKRELFPDFGEIGTLCRDIFFRNNLIMRACGDHIVSAPPLVMTRAEVDEMLAVAERCLEEFEQTLKARGLA 4ba5 B 1.76 BS01 PXG B 1 L59 W60 G120 S121 Y153 H154 G155 E226 D259 V261 R416 L27 W28 G88 S89 Y121 H122 G123 E194 D227 V229 R384 Y153 E226 D259 I262 K288 V423 Y121 E194 D227 I230 K256 V391 2.6.1.18 0004015,0005829,0008483,0030170,0042802 Q7NWG4 23519665 470 ARVMTRGEGVYLWDSEGNKIIDGMAGLWCVNVGYGRKDFAEAARRQMEELPFYNTFFKTTHPAVVELSSLLAEVTPAGFDRVFYTNSGSESVDTMIRMVRRYWDVQGKPEKKTLIGRWNGYHGSTIGGASLGGMKYMHEQGDLPIPGMAHIEQPWWYKHGKDMTPDEFGVVAARWLEEKILEIGADKVAAFVGEPIQGAGGVIVPPATYWPEIERICRKYDVLLVADEVICGFGRTGEWFGHQHFGFQPDLFTAAKGLSSGYLPIGAVFVGKRVAEGLIAGGDFNHGFTYSGHPVCAAVAHANVAALRDEGIVQRVKDDIGPYMQKRWRETFSRFEHVDDVRGVGMVQAFTLVKNKAKRELFPDFGEIGTLCRDIFFRNNLIMRACGDHIVSAPPLVMTRAEVDEMLAVAERCLEEFEQTLKARGLA 4cmf A 1.5 BS01 PXG A 1 V60 R77 F113 K179 E212 G215 F216 N217 L234 G236 I237 T238 T273 T274 A275 V60 R77 F113 K179 E212 G215 F216 N217 L234 G236 I237 T238 T273 T274 A275 Y58 V60 K179 E212 L234 Y58 V60 K179 E212 L234 2.6.1.42 0003824,0019752,0046394 C7YVL8 24618038 1323 MATMDKVFAGYAERQAVLEASKNPLAKGVAWIQGELVPLHEARIPLLDQGFMHSDLTYDVPSVWDGRFFRLEDHLNRLEASCKKMRLRMPLPREEVIKTLVDMVAKSGIRDAFVELIVTRGLTGVRGAKPEELLNNNLYMFIQPYVWVMDPDVQYTGGRAIVARTVRRVPPGSIDPTIKNLQWGDLVRGLFEANDRGATYPFLTDGDANLTEGSGFNVVLIKDGVLYTPDRGVLQGITRKSVIDAARSCGYEIRVEHVPIEATYQADEILMCTTAGGIMPITTLDDKPVKDGKVGPITKAIWDRYWAMHWEDEFSFKINYLE 4jev A 1.67 BS01 PXG A 1 I51 S107 G108 T109 F141 H142 E193 E198 D226 V228 Q229 K255 R377 I45 S101 G102 T103 F135 H136 E187 E192 D220 V222 Q223 K249 R371 F141 E193 D226 Q229 K255 T284 R377 F135 E187 D220 Q223 K249 T278 R371 2.6.1.11,2.6.1.17 0003992,0005737,0006520,0006525,0006526,0008483,0009016,0009085,0009089,0030170,0042802 P40732 501 AITRATFDEVILPVYAPADFIPVKGKGSRVWDQQGKEYIDFAGGIAVTALGHCHPALVEALKSQGETLWHTSNVFTNEPALRLGRKLIDATFAERVLFMNSGTEANETAFKLARHYACVRHSPFKTKIIAFHNAFHGRSLFTVSVGGQPKYSDGFGPKPADIIHVPFNDLHAVKAVMDDHTCAVVVEPIQGEGGVQAATPEFLKGLRDLCDEHQALLVFDEVQCGMGRTGDLFAYMHYGVTPDILTSAKALGGGFPVSAMLTTQEIASAFHVGSHGSTYGGNPLACAVAGATFDIINTPEVLQGIHTKRQQFVQHLQAIDEQFDIFSDIRGMGLLIGAELKPKYKGRARDFLYAGAEAGVMVLNAGADVMRFAPSLVVEEADIHEGMQRFAQAVGKVVALE 4jev B 1.67 BS01 PXG B 1 I51 S107 G108 T109 F141 H142 E193 E198 D226 V228 Q229 K255 R377 I46 S102 G103 T104 F136 H137 E188 E193 D221 V223 Q224 K250 R372 F141 E193 D226 Q229 K255 T284 R377 F136 E188 D221 Q224 K250 T279 R372 2.6.1.11,2.6.1.17 0003992,0005737,0006520,0006525,0006526,0008483,0009016,0009085,0009089,0030170,0042802 P40732 501 TAITRATFDEVILPVYAPADFIPVKGKGSRVWDQQGKEYIDFAGGIAVTALGHCHPALVEALKSQGETLWHTSNVFTNEPALRLGRKLIDATFAERVLFMNSGTEANETAFKLARHYACVRHSPFKTKIIAFHNAFHGRSLFTVSVGGQPKYSDGFGPKPADIIHVPFNDLHAVKAVMDDHTCAVVVEPIQGEGGVQAATPEFLKGLRDLCDEHQALLVFDEVQCGMGRTGDLFAYMHYGVTPDILTSAKALGGGFPVSAMLTTQEIASAFHVGSHGSTYGGNPLACAVAGATFDIINTPEVLQGIHTKRQQFVQHLQAIDEQFDIFSDIRGMGLLIGAELKPKYKGRARDFLYAGAEAGVMVLNAGADVMRFAPSLVVEEADIHEGMQRFAQAVGKVVALE 4uug A 1.6 BS01 PXG A 1 R77 K179 E212 G215 F216 N217 L234 G236 I237 T238 T273 T274 A275 R76 K178 E211 G214 F215 N216 L233 G235 I236 T237 T272 T273 A274 Y58 K179 E212 L234 Y57 K178 E211 L233 2.6.1.- 0003824,0005575,0008483,0019752,0046394 Q4WH08 25400251 401 ASMDKVFSGYYARQKLLERSDNPFSKGIAYVEGKLVLPSDARIPLLDEGFMHSDLTYDVISVWDGRFFRLDDHLQRILESCDKMRLKFPLALSSVKNILAEMVAKSGIRDAFVEVIVTRGLTGVRGSKPEDLYNNNIYLLVLPYIWVMAPENQLHGGEAIITRTVRRTPPGAFDPTIKNLQWGDLTKGLFEAMDRGATYPFLTDGDTNLTEGSGFNIVLVKNGIIYTPDRGVLRGITRKSVIDVARANSIDIRLEVVPVEQAYHSDEIFMCTTAGGIMPITLLDGQPVNDGQVGPITKKIWDGYWEMHYNPAYSFPVDYG 4uug B 1.6 BS01 PXG B 1 R77 K179 W183 E212 G215 F216 N217 L234 G236 I237 T238 T273 T274 A275 R76 K178 W182 E211 G214 F215 N216 L233 G235 I236 T237 T272 T273 A274 Y58 K179 E212 L234 Y57 K178 E211 L233 2.6.1.- 0003824,0005575,0008483,0019752,0046394 Q4WH08 25400251 401 ASMDKVFSGYYARQKLLERSDNPFSKGIAYVEGKLVLPSDARIPLLDEGFMHSDLTYDVISVWDGRFFRLDDHLQRILESCDKMRLKFPLALSSVKNILAEMVAKSGIRDAFVEVIVTRGLTGVRGSKPEDLYNNNIYLLVLPYIWVMAPENQLHGGEAIITRTVRRTPPGAFDPTIKNLQWGDLTKGLFEAMDRGATYPFLTDGDTNLTEGSGFNIVLVKNGIIYTPDRGVLRGITRKSVIDVARANSIDIRLEVVPVEQAYHSDEIFMCTTAGGIMPITLLDGQPVNDGQVGPITKKIWDGYWEMHYNPAYSFPVDYG 5dj9 A 1.55 BS01 PXG A 1 Y49 V79 G136 A137 Y171 W172 E229 D257 I259 Q260 K286 Y31 V61 G118 A119 Y153 W154 E211 D239 I241 Q242 K268 Y171 E224 D257 Q260 K286 T316 R409 Y153 E206 D239 Q242 K268 T298 R391 2.6.1.13 0004587,0005737,0008483,0010121,0019544,0030170,0042802,0055129 S8EY38 505 KTNIEAYRDGLKLKTEEDFFACDRQYVCQNYAPVPVVISKGKGARVWDINGNEYYDFLAGVSSLSQGHCHPRVIAALCRQAERLTLTLRAFGNDVTGPACRFMAEMFGYDRVLLMNTGAEAGESALKIARKWAYEVKEIPPDSAKVILCNNNYWGRTITACSSSTTFDCYNNFGPFTPGFELIDYDDVGALEEALKDPNVAAFFVEPIQGEGGVNVPKPGYLKRAHELCRSKNVLLIVDEIQTGLCRTGRLLAADHDEVHPDILLLGKSLSAGVVPISAVMGRADVMDVLKPGTHGSTFGGNPLACAVAVEALTVLKDEKLADRAERLGAQFRDCLRRELYGKVPWIKEIRGRGLLNAVEVDSDAIDPNDVVMKLKENGILSKPTRGRVMRFIPPLVITDEEHRDATTRIIKSFLAVEEER 5dj9 A 1.55 BS02 PXG B 1 S315 T316 S297 T298 Y171 E224 D257 Q260 K286 T316 R409 Y153 E206 D239 Q242 K268 T298 R391 2.6.1.13 0004587,0005737,0008483,0010121,0019544,0030170,0042802,0055129 S8EY38 508 KTNIEAYRDGLKLKTEEDFFACDRQYVCQNYAPVPVVISKGKGARVWDINGNEYYDFLAGVSSLSQGHCHPRVIAALCRQAERLTLTLRAFGNDVTGPACRFMAEMFGYDRVLLMNTGAEAGESALKIARKWAYEVKEIPPDSAKVILCNNNYWGRTITACSSSTTFDCYNNFGPFTPGFELIDYDDVGALEEALKDPNVAAFFVEPIQGEGGVNVPKPGYLKRAHELCRSKNVLLIVDEIQTGLCRTGRLLAADHDEVHPDILLLGKSLSAGVVPISAVMGRADVMDVLKPGTHGSTFGGNPLACAVAVEALTVLKDEKLADRAERLGAQFRDCLRRELYGKVPWIKEIRGRGLLNAVEVDSDAIDPNDVVMKLKENGILSKPTRGRVMRFIPPLVITDEEHRDATTRIIKSFLAVEEER 5dj9 B 1.55 BS01 PXG A 1 S315 T316 S296 T297 Y171 E224 D257 Q260 K286 T316 R409 Y152 E205 D238 Q241 K267 T297 R390 2.6.1.13 0004587,0005737,0008483,0010121,0019544,0030170,0042802,0055129 S8EY38 505 TNIEAYRDGLKLKTEEDFFACDRQYVCQNYAPVPVVISKGKGARVWDINGNEYYDFLAGVSSLSQGHCHPRVIAALCRQAERLTLTLRAFGNDVTGPACRFMAEMFGYDRVLLMNTGAEAGESALKIARKWAYEVKEIPPDSAKVILCNNNYWGRTITACSSSTTFDCYNNFGPFTPGFELIDYDDVGALEEALKDPNVAAFFVEPIQGEGGVNVPKPGYLKRAHELCRSKNVLLIVDEIQTGLCRTGRLLAADHDEVHPDILLLGKSLSAGVVPISAVMGRADVMDVLKPGTHGSTFGGNPLACAVAVEALTVLKDEKLADRAERLGAQFRDCLRRELYGKVPWIKEIRGRGLLNAVEVDSDAIDPNDVVMKLKENGILSKPTRGRVMRFIPPLVITDEEHRDATTRIIKSFLAVEEERK 5dj9 B 1.55 BS02 PXG B 1 Y49 G136 A137 Y171 W172 E229 D257 Q260 K286 Y30 G117 A118 Y152 W153 E210 D238 Q241 K267 Y171 E224 D257 Q260 K286 T316 R409 Y152 E205 D238 Q241 K267 T297 R390 2.6.1.13 0004587,0005737,0008483,0010121,0019544,0030170,0042802,0055129 S8EY38 508 TNIEAYRDGLKLKTEEDFFACDRQYVCQNYAPVPVVISKGKGARVWDINGNEYYDFLAGVSSLSQGHCHPRVIAALCRQAERLTLTLRAFGNDVTGPACRFMAEMFGYDRVLLMNTGAEAGESALKIARKWAYEVKEIPPDSAKVILCNNNYWGRTITACSSSTTFDCYNNFGPFTPGFELIDYDDVGALEEALKDPNVAAFFVEPIQGEGGVNVPKPGYLKRAHELCRSKNVLLIVDEIQTGLCRTGRLLAADHDEVHPDILLLGKSLSAGVVPISAVMGRADVMDVLKPGTHGSTFGGNPLACAVAVEALTVLKDEKLADRAERLGAQFRDCLRRELYGKVPWIKEIRGRGLLNAVEVDSDAIDPNDVVMKLKENGILSKPTRGRVMRFIPPLVITDEEHRDATTRIIKSFLAVEEERK 5mr0 A 1.98 BS01 PXG A 1 R51 K150 Y154 E183 G186 D187 L206 G208 I209 T210 G245 T246 R51 K147 Y151 E180 G183 D184 L203 G205 I206 T207 G242 T243 F32 G34 K150 E183 L206 F32 G34 K147 E180 L203 2.6.1.42 0003824,0004084,0008483,0008652,0009081,0009082,0009097,0009098,0009099,0019752,0046394,0050048,0052654,0052655,0052656 O29329 30733943 301 MLYVYMDGEFVPENEAKVSIFDHGFLYGDGVFEGIRAYNGRVFRLKEHIDRLYDSAKAIDLEIPITKEEFMEIILETLRKNNLRDAYIRPIVTRGIGDLGLDPRKCQNPSIIVITKPWGGDLYEKGLTAITVAVRRNSFDALPPNIKSLNYLNNILAKIEANAKGGDEAIFLDRNGYVSEGSGDNIFVVKNGAITTPPTINNLRGITREAVIEIINRLGIPFKETNIGLYDLYTADEVFVTGTAAEIAPIVVIDGRKIGDGKPGEITRKLMEEFSKLTESEGVPIYE 5mr0 B 1.98 BS01 PXG B 1 R51 K150 Y154 E183 G186 D187 L206 G208 I209 T210 G245 T246 R51 K146 Y150 E179 G182 D183 L202 G204 I205 T206 G241 T242 F32 G34 K150 E183 L206 F32 G34 K146 E179 L202 2.6.1.42 0003824,0004084,0008483,0008652,0009081,0009082,0009097,0009098,0009099,0019752,0046394,0050048,0052654,0052655,0052656 O29329 30733943 301 MLYVYMDGEFVPENEAKVSIFDHGFLYGDGVFEGIRAYNGRVFRLKEHIDRLYDSAKAIDLEIPITKEEFMEIILETLRKNNLRDAYIRPIVTRGIGDLGLDPRKCQNPSIIVITKPWGDLYEKGLTAITVAVRRNSFDALPPNIKSLNYLNNILAKIEANAKGGDEAIFLDRNGYVSEGSGDNIFVVKNGAITTPPTINNLRGITREAVIEIINRLGIPFKETNIGLYDLYTADEVFVTGTAAEIAPIVVIDGRKIGDGKPGEITRKLMEEFSKLTESEGVPIYE 5mr0 C 1.98 BS01 PXG C 1 R51 K150 Y154 E183 G186 D187 L206 G208 I209 T210 G245 T246 R51 K146 Y150 E179 G182 D183 L202 G204 I205 T206 G241 T242 F32 G34 K150 E183 L206 F32 G34 K146 E179 L202 2.6.1.42 0003824,0004084,0008483,0008652,0009081,0009082,0009097,0009098,0009099,0019752,0046394,0050048,0052654,0052655,0052656 O29329 30733943 301 MLYVYMDGEFVPENEAKVSIFDHGFLYGDGVFEGIRAYNGRVFRLKEHIDRLYDSAKAIDLEIPITKEEFMEIILETLRKNNLRDAYIRPIVTRGIGDLGLDPRKCQNPSIIVITKPWGDLYEKGLTAITVAVRRNSFDALPPNIKSLNYLNNILAKIEANAKGGDEAIFLDRNGYVSEGSGDNIFVVKNGAITTPPTINNLRGITREAVIEIINRLGIPFKETNIGLYDLYTADEVFVTGTAAEIAPIVVIDGRKIGDGKPGEITRKLMEEFSKLTESEGVPIYE 5mr0 D 1.98 BS01 PXG C 1 G100 L101 G100 L101 F32 G34 K150 E183 L206 F32 G34 K150 E183 L206 2.6.1.42 0003824,0004084,0008483,0008652,0009081,0009082,0009097,0009098,0009099,0019752,0046394,0050048,0052654,0052655,0052656 O29329 30733943 301 MLYVYMDGEFVPENEAKVSIFDHGFLYGDGVFEGIRAYNGRVFRLKEHIDRLYDSAKAIDLEIPITKEEFMEIILETLRKNNLRDAYIRPIVTRGIGDLGLDPRKCQNPSIIVITKPWGKLYGDLYEKGLTAITVAVRRNSFDALPPNIKSLNYLNNILAKIEANAKGGDEAIFLDRNGYVSEGSGDNIFVVKNGAITTPPTINNLRGITREAVIEIINRLGIPFKETNIGLYDLYTADEVFVTGTAAEIAPIVVIDGRKIGDGKPGEITRKLMEEFSKLTESEGVPIYE 5mr0 D 1.98 BS02 PXG D 1 R51 K150 Y154 E183 G186 D187 L206 I209 T210 G245 T246 R51 K150 Y154 E183 G186 D187 L206 I209 T210 G245 T246 F32 G34 K150 E183 L206 F32 G34 K150 E183 L206 2.6.1.42 0003824,0004084,0008483,0008652,0009081,0009082,0009097,0009098,0009099,0019752,0046394,0050048,0052654,0052655,0052656 O29329 30733943 301 MLYVYMDGEFVPENEAKVSIFDHGFLYGDGVFEGIRAYNGRVFRLKEHIDRLYDSAKAIDLEIPITKEEFMEIILETLRKNNLRDAYIRPIVTRGIGDLGLDPRKCQNPSIIVITKPWGKLYGDLYEKGLTAITVAVRRNSFDALPPNIKSLNYLNNILAKIEANAKGGDEAIFLDRNGYVSEGSGDNIFVVKNGAITTPPTINNLRGITREAVIEIINRLGIPFKETNIGLYDLYTADEVFVTGTAAEIAPIVVIDGRKIGDGKPGEITRKLMEEFSKLTESEGVPIYE 5mr0 E 1.98 BS01 PXG E 1 R51 K150 Y154 E183 G186 D187 L206 G208 I209 T210 G245 T246 R51 K147 Y151 E180 G183 D184 L203 G205 I206 T207 G242 T243 F32 G34 K150 E183 L206 F32 G34 K147 E180 L203 2.6.1.42 0003824,0004084,0008483,0008652,0009081,0009082,0009097,0009098,0009099,0019752,0046394,0050048,0052654,0052655,0052656 O29329 30733943 301 MLYVYMDGEFVPENEAKVSIFDHGFLYGDGVFEGIRAYNGRVFRLKEHIDRLYDSAKAIDLEIPITKEEFMEIILETLRKNNLRDAYIRPIVTRGIGDLGLDPRKCQNPSIIVITKPWGGDLYEKGLTAITVAVRRNSFDALPPNIKSLNYLNNILAKIEANAKGGDEAIFLDRNGYVSEGSGDNIFVVKNGAITTPPTINNLRGITREAVIEIINRLGIPFKETNIGLYDLYTADEVFVTGTAAEIAPIVVIDGRKIGDGKPGEITRKLMEEFSKLTESEGVPIYE 5mr0 F 1.98 BS01 PXG E 1 G100 L101 G100 L101 F32 G34 K150 E183 L206 F32 G34 K147 E180 L203 2.6.1.42 0003824,0004084,0008483,0008652,0009081,0009082,0009097,0009098,0009099,0019752,0046394,0050048,0052654,0052655,0052656 O29329 30733943 301 MLYVYMDGEFVPENEAKVSIFDHGFLYGDGVFEGIRAYNGRVFRLKEHIDRLYDSAKAIDLEIPITKEEFMEIILETLRKNNLRDAYIRPIVTRGIGDLGLDPRKCQNPSIIVITKPWGGDLYEKGLTAITVAVRRNSFDALPPNIKSLNYLNNILAKIEANAKGGDEAIFLDRNGYVSEGSGDNIFVVKNGAITTPPTINNLRGITREAVIEIINRLGIPFKETNIGLYDLYTADEVFVTGTAAEIAPIVVIDGRKIGDGKPGEITRKLMEEFSKLTESEGVPIYE