1ckp A 2.05 BS01 PVB A 1 I10 A31 F80 L83 Q85 D86 L134 I10 A31 F72 L75 Q77 D78 L126 D127 K129 Q131 N132 D145 T165 D119 K121 Q123 N124 D137 T146 2.7.11.22 0000082,0000086,0000122,0000287,0000307,0000781,0000793,0000805,0000806,0001673,0004672,0004674,0004693,0005515,0005524,0005634,0005635,0005654,0005667,0005737,0005768,0005813,0005829,0005856,0006260,0006281,0006338,0006351,0006468,0006813,0007099,0007165,0007265,0007346,0008284,0010389,0010468,0015030,0016301,0016310,0018105,0019904,0030332,0031453,0031571,0032298,0035173,0043247,0043687,0045740,0045893,0046872,0051298,0051301,0051321,0071732,0090398,0097123,0097124,0097134,0097135,0097472,0106310,1905784 IC50=6nM P24941 9677190 299 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 1v0p A 2.0 BS01 PVB A 1 I10 G11 G13 V18 A30 F79 L82 D83 D85 Q129 L132 I10 G11 G13 V18 A30 F79 L82 D83 D85 Q129 L132 D125 K127 Q129 N130 D143 T163 D125 K127 Q129 N130 D143 T154 2.7.11.22,2.7.11.23 0004672,0004674,0004693,0005524,0005634,0005737,0006357,0006468,0008353,0016310,0046872,0051301,0051726,0106310 ic50=0.13uM -logKd/Ki=6.89, IC50=0.13uM Q07785 14604523 1287 MEKYHGLEKIGEGTYGVVYKAQNNYGETFALKKIRLEKEDEGIPSTTIREISILKELKHSNIVKLYDVIHTKKRLVLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCHDRRVLHRDLKPQNLLINREGELKIADFGLARAFGIVTLWYRAPDVLMGSKKYSTTIDIWSVGCIFAEMVNGTPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKYDPNFTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKE 1v0p B 2.0 BS01 PVB B 1 I10 G11 E12 V18 A30 F79 H81 L82 D83 D85 Q129 L132 I9 G10 E11 V17 A29 F64 H66 L67 D68 D70 Q114 L117 D125 K127 Q129 N130 D143 D110 K112 Q114 N115 D128 2.7.11.22,2.7.11.23 0004672,0004674,0004693,0005524,0005634,0005737,0006357,0006468,0008353,0016310,0046872,0051301,0051726,0106310 ic50=0.13uM Q07785 14604523 1287 EKYHGLEKIGEGTYGVVYKAQNNYGETFALKPSTTIREISILKELKHSNIVKLYDVIHTLVLVFEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCHDRRVLHRDLKPQNLLINREGELKIADFGLARAFLWYRAPDVLMGSKKYSTTIDIWSVGCIFAEMVNGTPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKYDPNFTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKE 2x7g A 2.5 BS01 PVB A 1 L98 G99 W100 G101 L180 H182 M243 L18 G19 W20 G21 L100 H102 M163 D225 D145 2.7.11.1 0004672,0005524,0006468 P78362 800 PVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAELLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLNS 6bl8 A 2.5 BS01 PVB A 1 L248 G250 F317 M318 T319 G321 N322 L370 L16 G18 F85 M86 T87 G89 N90 L138 D363 A365 R367 N368 D381 P402 D131 A133 R135 N136 D149 P170 2.7.10.2 0004672,0004713,0005524,0006468 P00519 29474075 601 DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTFTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDPSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSI 6bl8 B 2.5 BS01 PVB B 1 L248 A269 T315 F317 M318 T319 G321 L370 F382 L16 A34 T80 F82 M83 T84 G86 L135 F147 D363 A365 R367 N368 D381 P402 D128 A130 R132 N133 D146 P166 2.7.10.2 0004672,0004713,0005524,0006468 P00519 29474075 601 DKWEMERTDITMKHKLGYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTFTAHGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDPSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISD