1aor A 2.3 BS03 PTE A 1 R76 A92 N93 G95 R182 A183 G185 R186 E311 E313 D338 D343 T344 R444 H448 I449 K450 D489 C494 L495 F496 R76 A92 N93 G95 R182 A183 G185 R186 E311 E313 D338 D343 T344 R444 H448 I449 K450 D489 C494 L495 F496 1.2.7.5 0009055,0016491,0016625,0033726,0046872,0051536,0051539 Q51739 7878465 609 MYGNWGRFIRVNLSTGDIKVEEYDEELAKKWLGSRGLAIYLLLKEMDPTVDPLSPENKLIIAAGPLTGTSAPTGGRYNVVTKSPLTGFITMANSGGYFGAELKFAGYDAIVVEGKAEKPVYIYIKDEHIEIRDASHIWGKKVSETEATIRKEVGSEKVKIASIGPAGENLVKFAAIMNDGHRAAGRGGVGAVMGSKNLKAIAVEGSKTVPIADKQKFMLVVREKVNKLRNDPVAGGGLPKYGTAVLVNIINENGLYPVKNFQTGVYPYAYEQSGEAMAAKYLVRNKPCYACPIGCGRVNRLPTVGETEGPEYESVWALGANLGINDLASIIEANHMCDELGLDTISTGGTLATAMELYEKGHIKDEELGDAPPFRWGNTEVLHYYIEKIAKREGFGDKLAEGSYRLAESYGHPELSMTVKKLELPAYDPRGAEGHGLGYATNNRGGCHIKNYMISPEILGYPYKMDPHDVSDDKIKMLILFQDLTALIDSAGLCLFTTFGLGADDYRDLLNAALGWDFTTEDYLKIGERIWNAERLFNLKAGLDPARDDTLPKRFLEEPMPEGPNKGHTVRLKEMLPRYYKLRGWTEDGKIPKEKLEELGIAEFY 1aor B 2.3 BS03 PTE B 1 R76 A92 N93 G95 R182 A183 A184 G185 R186 E311 D338 L342 D343 T344 R444 H448 I449 K450 D489 C494 L495 F496 R76 A92 N93 G95 R182 A183 A184 G185 R186 E311 D338 L342 D343 T344 R444 H448 I449 K450 D489 C494 L495 F496 1.2.7.5 0009055,0016491,0016625,0033726,0046872,0051536,0051539 Q51739 7878465 608 MYGNWGRFIRVNLSTGDIKVEEYDEELAKKWLGSRGLAIYLLLKEMDPTVDPLSPENKLIIAAGPLTGTSAPTGGRYNVVTKSPLTGFITMANSGGYFGAELKFAGYDAIVVEGKAEKPVYIYIKDEHIEIRDASHIWGKKVSETEATIRKEVGSEKVKIASIGPAGENLVKFAAIMNDGHRAAGRGGVGAVMGSKNLKAIAVEGSKTVPIADKQKFMLVVREKVNKLRNDPVAGGGLPKYGTAVLVNIINENGLYPVKNFQTGVYPYAYEQSGEAMAAKYLVRNKPCYACPIGCGRVNRLPTVGETEGPEYESVWALGANLGINDLASIIEANHMCDELGLDTISTGGTLATAMELYEKGHIKDEELGDAPPFRWGNTEVLHYYIEKIAKREGFGDKLAEGSYRLAESYGHPELSMTVKKLELPAYDPRGAEGHGLGYATNNRGGCHIKNYMISPEILGYPYKMDPHDVSDDKIKMLILFQDLTALIDSAGLCLFTTFGLGADDYRDLLNAALGWDFTTEDYLKIGERIWNAERLFNLKAGLDPARDDTLPKRFLEEPMPEGPNKGHTVRLKEMLPRYYKLRGWTEDGKIPKEKLEELGIAEFY 1b4n A 2.4 BS04 PTE A 1 K75 G91 N92 L93 G94 R180 A181 A182 G183 R184 D306 E308 N309 D333 M337 D338 T339 H436 H437 K438 F485 E486 A490 C491 R492 L493 K75 G91 N92 L93 G94 R180 A181 A182 G183 R184 D306 E308 N309 D333 M337 D338 T339 H436 H437 K438 F477 E478 A482 C483 R484 L485 1.2.7.5 0009055,0016491,0016625,0033726,0046872,0051536,0051539 Q8U1K3 10024458 623 MYGWWGRILRVNLTTGEVKVQEYPEEVAKKFIGGRGLAAWILWNEARGVEPLSPENKLIFAAGPFNGLPTPSGGKLVVAAKSPLTGGYGDGNLGTMASVHLRRAGYDALVVEGKAKKPVYIYIEDDNVSILSAEGLWGKTTFETERELKEIHGKNVGVLTIGPAGENLVKYAVVISQEGRAAGRPGMGAVMGSKKLKAVVIRGTKEIPVADKEELKKLSQEAYNEILNSPGYPFWKRQGTMAAVEWCNTNYALPTRNFSDGYFEFARSIDGYTMEGMKVQQRGCPYCNMPCGNVVLDAEGQESELDYENVALLGSNLGIGKLNEVSVLNRIADEMGMDTISLGVSIAHVMEAVERGILKEGPTFGDFKGAKQLALDIAYRKGELGNLAAEGVKAMAEKLGTHDFAMHVKGLEVSGYNCYIYPAMALAYGTSAIGAHHKEAWVIAWEIGTAPIEYKISYDPIKAQKVVELQRLRGGLFEMLTACRLPWVEVGLSLDYYPKLLKAITGVTYTWDDLYKAADRVYSLIRAYWVREFNGKWDRKMDYPPKRWFTEGLKSGPHKGEHLDEKKYDELLSEYYRIRGWDERGIPKKETLKELDLDFVIPELEKVTNLE 1b4n B 2.4 BS04 PTE B 1 K75 G91 N92 L93 G94 R180 A181 G183 R184 D306 N309 D333 D338 T339 H436 H437 K438 F485 E486 A490 C491 R492 K75 G91 N92 L93 G94 R180 A181 G183 R184 D306 N309 D333 D338 T339 H436 H437 K438 F477 E478 A482 C483 R484 1.2.7.5 0009055,0016491,0016625,0033726,0046872,0051536,0051539 Q8U1K3 10024458 623 MYGWWGRILRVNLTTGEVKVQEYPEEVAKKFIGGRGLAAWILWNEARGVEPLSPENKLIFAAGPFNGLPTPSGGKLVVAAKSPLTGGYGDGNLGTMASVHLRRAGYDALVVEGKAKKPVYIYIEDDNVSILSAEGLWGKTTFETERELKEIHGKNVGVLTIGPAGENLVKYAVVISQEGRAAGRPGMGAVMGSKKLKAVVIRGTKEIPVADKEELKKLSQEAYNEILNSPGYPFWKRQGTMAAVEWCNTNYALPTRNFSDGYFEFARSIDGYTMEGMKVQQRGCPYCNMPCGNVVLDAEGQESELDYENVALLGSNLGIGKLNEVSVLNRIADEMGMDTISLGVSIAHVMEAVERGILKEGPTFGDFKGAKQLALDIAYRKGELGNLAAEGVKAMAEKLGTHDFAMHVKGLEVSGYNCYIYPAMALAYGTSAIGAHHKEAWVIAWEIGTAPIEYKISYDPIKAQKVVELQRLRGGLFEMLTACRLPWVEVGLSLDYYPKLLKAITGVTYTWDDLYKAADRVYSLIRAYWVREFNGKWDRKMDYPPKRWFTEGLKSGPHKGEHLDEKKYDELLSEYYRIRGWDERGIPKKETLKELDLDFVIPELEKVTNLE 1b4n C 2.4 BS04 PTE C 1 K75 G91 N92 L93 G94 R180 A181 A182 G183 R184 D306 E308 N309 A332 D333 M337 D338 T339 I340 H436 H437 K438 E486 A490 C491 R492 L493 K75 G91 N92 L93 G94 R180 A181 A182 G183 R184 D306 E308 N309 A332 D333 M337 D338 T339 I340 H436 H437 K438 E478 A482 C483 R484 L485 1.2.7.5 0009055,0016491,0016625,0033726,0046872,0051536,0051539 Q8U1K3 10024458 623 MYGWWGRILRVNLTTGEVKVQEYPEEVAKKFIGGRGLAAWILWNEARGVEPLSPENKLIFAAGPFNGLPTPSGGKLVVAAKSPLTGGYGDGNLGTMASVHLRRAGYDALVVEGKAKKPVYIYIEDDNVSILSAEGLWGKTTFETERELKEIHGKNVGVLTIGPAGENLVKYAVVISQEGRAAGRPGMGAVMGSKKLKAVVIRGTKEIPVADKEELKKLSQEAYNEILNSPGYPFWKRQGTMAAVEWCNTNYALPTRNFSDGYFEFARSIDGYTMEGMKVQQRGCPYCNMPCGNVVLDAEGQESELDYENVALLGSNLGIGKLNEVSVLNRIADEMGMDTISLGVSIAHVMEAVERGILKEGPTFGDFKGAKQLALDIAYRKGELGNLAAEGVKAMAEKLGTHDFAMHVKGLEVSGYNCYIYPAMALAYGTSAIGAHHKEAWVIAWEIGTAPIEYKISYDPIKAQKVVELQRLRGGLFEMLTACRLPWVEVGLSLDYYPKLLKAITGVTYTWDDLYKAADRVYSLIRAYWVREFNGKWDRKMDYPPKRWFTEGLKSGPHKGEHLDEKKYDELLSEYYRIRGWDERGIPKKETLKELDLDFVIPELEKVTNLE 1b4n D 2.4 BS04 PTE D 1 K75 G91 N92 L93 G94 R180 A181 A182 G183 R184 D306 E308 N309 A332 D333 D338 T339 H436 H437 K438 E486 A490 C491 R492 K75 G91 N92 L93 G94 R180 A181 A182 G183 R184 D306 E308 N309 A332 D333 D338 T339 H436 H437 K438 E478 A482 C483 R484 1.2.7.5 0009055,0016491,0016625,0033726,0046872,0051536,0051539 Q8U1K3 10024458 623 MYGWWGRILRVNLTTGEVKVQEYPEEVAKKFIGGRGLAAWILWNEARGVEPLSPENKLIFAAGPFNGLPTPSGGKLVVAAKSPLTGGYGDGNLGTMASVHLRRAGYDALVVEGKAKKPVYIYIEDDNVSILSAEGLWGKTTFETERELKEIHGKNVGVLTIGPAGENLVKYAVVISQEGRAAGRPGMGAVMGSKKLKAVVIRGTKEIPVADKEELKKLSQEAYNEILNSPGYPFWKRQGTMAAVEWCNTNYALPTRNFSDGYFEFARSIDGYTMEGMKVQQRGCPYCNMPCGNVVLDAEGQESELDYENVALLGSNLGIGKLNEVSVLNRIADEMGMDTISLGVSIAHVMEAVERGILKEGPTFGDFKGAKQLALDIAYRKGELGNLAAEGVKAMAEKLGTHDFAMHVKGLEVSGYNCYIYPAMALAYGTSAIGAHHKEAWVIAWEIGTAPIEYKISYDPIKAQKVVELQRLRGGLFEMLTACRLPWVEVGLSLDYYPKLLKAITGVTYTWDDLYKAADRVYSLIRAYWVREFNGKWDRKMDYPPKRWFTEGLKSGPHKGEHLDEKKYDELLSEYYRIRGWDERGIPKKETLKELDLDFVIPELEKVTNLE 6x1o A 2.094 BS02 PTE A 1 K77 S93 V94 L95 S96 H195 A196 A197 G198 Y199 D326 E328 D353 D358 G359 I360 H469 T470 Y489 D490 I494 C495 N496 F497 K77 S93 V94 L95 S96 H195 A196 A197 G198 Y199 D326 E328 D353 D358 G359 I360 H469 T470 Y489 D490 I494 C495 N496 F497 1.2.7.5 0009055,0016491,0016625,0046872,0051536,0051539 I6V2C3 36269456 702 MYAYNGKLLDVDLTREKVKEVELSEDVLKKFYGGRGLGTYILWKELGEKWEKVDPLGEENLLLILTGPLTGYYPGMKTSIVSKSPESNGVVGSVLSSELGLELKAAGYDGIIIRGKAKSPVYLFIHNDTVEIRDATKYWGMGGIELYKTLLKEVHEEIRKKEKLKGVPKEPAMIYIGKGGENKVRFAAIMTKLMHAAGYGGYGAVMGSKNLKAVIAKGSGPLPEVYDKEKMKVLLREFWKELFSMTTFREWGTGAGGYSVGHDRSSEPIRNWQEEYHDNEEISVVNFENRTWIKKYWADYGCPVNCMKISYLRYGPYKGSISDAPDYELQAYMGTNLGIFEPEKIVYLSYLVDELGLDGINTGNILGFAAELYQRGILTKEDLGFELNWGDEKAFAKLLHLIVEKEGIGKILAEGTYRAALKISEIKGIDVTKYAVHVKGIAVGAHGIRSELDYTKDISYAVSVQGGDHTSTAALPAKGYTGELVEAFYDSAVICNFVTKPGFEKIIEFGNALSGFNITPEQWLNEIGLRIIHLQRILLLLGGPDVYWDPRKDDDNPPRFYEPLPSGPVKGKAPNREDIKAKVKQYYEEIGYDEHGIPKEEVLEELGIGEAKREVKRIKKRLN 6x1o C 2.094 BS02 PTE C 1 K77 S93 V94 L95 S96 H195 A196 A197 G198 Y199 D326 E328 D353 D358 G359 I360 H469 T470 Y489 D490 I494 C495 N496 F497 K77 S93 V94 L95 S96 H195 A196 A197 G198 Y199 D326 E328 D353 D358 G359 I360 H469 T470 Y489 D490 I494 C495 N496 F497 1.2.7.5 0009055,0016491,0016625,0046872,0051536,0051539 I6V2C3 36269456 702 MYAYNGKLLDVDLTREKVKEVELSEDVLKKFYGGRGLGTYILWKELGEKWEKVDPLGEENLLLILTGPLTGYYPGMKTSIVSKSPESNGVVGSVLSSELGLELKAAGYDGIIIRGKAKSPVYLFIHNDTVEIRDATKYWGMGGIELYKTLLKEVHEEIRKKEKLKGVPKEPAMIYIGKGGENKVRFAAIMTKLMHAAGYGGYGAVMGSKNLKAVIAKGSGPLPEVYDKEKMKVLLREFWKELFSMTTFREWGTGAGGYSVGHDRSSEPIRNWQEEYHDNEEISVVNFENRTWIKKYWADYGCPVNCMKISYLRYGPYKGSISDAPDYELQAYMGTNLGIFEPEKIVYLSYLVDELGLDGINTGNILGFAAELYQRGILTKEDLGFELNWGDEKAFAKLLHLIVEKEGIGKILAEGTYRAALKISEIKGIDVTKYAVHVKGIAVGAHGIRSELDYTKDISYAVSVQGGDHTSTAALPAKGYTGELVEAFYDSAVICNFVTKPGFEKIIEFGNALSGFNITPEQWLNEIGLRIIHLQRILLLLGGPDVYWDPRKDDDNPPRFYEPLPSGPVKGKAPNREDIKAKVKQYYEEIGYDEHGIPKEEVLEELGIGEAKREVKRIKKRLNL 6x6u A 1.944 BS01 PTE A 1 K77 S93 V94 L95 S96 H195 A196 A197 G198 Y199 D326 E328 D353 D358 G359 I360 H469 T470 E486 D490 I494 C495 N496 F497 K77 S93 V94 L95 S96 H195 A196 A197 G198 Y199 D326 E328 D353 D358 G359 I360 H469 T470 E486 D490 I494 C495 N496 F497 1.2.7.5 0009055,0016491,0016625,0046872,0051536,0051539 I6V2C3 36269456 701 MYAYNGKLLDVDLTREKVKEVELSEDVLKKFYGGRGLGTYILWKELGEKWEKVDPLGEENLLLILTGPLTGYYPGMKTSIVSKSPESNGVVGSVLSSELGLELKAAGYDGIIIRGKAKSPVYLFIHNDTVEIRDATKYWGMGGIELYKTLLKEVHEEIRKKEKLKGVPKEPAMIYIGKGGENKVRFAAIMTKLMHAAGYGGYGAVMGSKNLKAVIAKGSGPLPEVYDKEKMKVLLREFWKELFSMTTFREWGTGAGGYSVGHDRSSEPIRNWQEEYHDNEEISVVNFENRTWIKKYWADYGCPVNCMKISYLRYGPYKGSISDAPDYELQAYMGTNLGIFEPEKIVYLSYLVDELGLDGINTGNILGFAAELYQRGILTKEDLGFELNWGDEKAFAKLLHLIVEKEGIGKILAEGTYRAALKISEIKGIDVTKYAVHVKGIAVGAHGIRSELDYTKDISYAVSVQGGDHTSTAALPAKGYTGELVEAFYDSAVICNFVTKPGFEKIIEFGNALSGFNITPEQWLNEIGLRIIHLQRILLLLGGPDVYWDPRKDDDNPPRFYEPLPSGPVKGKAPNREDIKAKVKQYYEEIGYDEHGIPKEEVLEELGIGEAKREVKRIKKRLN 6x6u C 1.944 BS01 PTE C 1 K77 S93 V94 L95 S96 H195 A196 G198 Y199 D326 E328 D353 D358 G359 I360 H469 T470 E486 D490 I494 C495 N496 F497 K77 S93 V94 L95 S96 H195 A196 G198 Y199 D326 E328 D353 D358 G359 I360 H469 T470 E486 D490 I494 C495 N496 F497 1.2.7.5 0009055,0016491,0016625,0046872,0051536,0051539 I6V2C3 36269456 701 MYAYNGKLLDVDLTREKVKEVELSEDVLKKFYGGRGLGTYILWKELGEKWEKVDPLGEENLLLILTGPLTGYYPGMKTSIVSKSPESNGVVGSVLSSELGLELKAAGYDGIIIRGKAKSPVYLFIHNDTVEIRDATKYWGMGGIELYKTLLKEVHEEIRKKEKLKGVPKEPAMIYIGKGGENKVRFAAIMTKLMHAAGYGGYGAVMGSKNLKAVIAKGSGPLPEVYDKEKMKVLLREFWKELFSMTTFREWGTGAGGYSVGHDRSSEPIRNWQEEYHDNEEISVVNFENRTWIKKYWADYGCPVNCMKISYLRYGPYKGSISDAPDYELQAYMGTNLGIFEPEKIVYLSYLVDELGLDGINTGNILGFAAELYQRGILTKEDLGFELNWGDEKAFAKLLHLIVEKEGIGKILAEGTYRAALKISEIKGIDVTKYAVHVKGIAVGAHGIRSELDYTKDISYAVSVQGGDHTSTAALPAKGYTGELVEAFYDSAVICNFVTKPGFEKIIEFGNALSGFNITPEQWLNEIGLRIIHLQRILLLLGGPDVYWDPRKDDDNPPRFYEPLPSGPVKGKAPNREDIKAKVKQYYEEIGYDEHGIPKEEVLEELGIGEAKREVKRIKKRLN