1br6 A 2.3 BS01 PT1 A 1 N78 Y80 V81 G121 Y123 I172 S176 E177 R180 N79 Y81 V82 G122 Y124 I173 S177 E178 R181 V81 E177 R180 V82 E178 R181 3.2.2.22 0017148,0030598 Ki=0.6mM -logKd/Ki=3.22, Ki=0.6mM P02879 9086280 301 MIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQF 1hwp A 3.1 BS01 PT1 A 1 Y77 L78 G114 Y116 I158 E163 R166 W197 Y77 L78 G114 Y116 I158 E163 R166 W197 L78 E163 R166 L78 E163 R166 3.2.2.22 0017148,0030598 Q9AVR2 11288182 321 IDYPSVSFNLAGAKSTTYRDFLKNLRDRVATGTYEVNGLPVLRRESEVQVKNRFVLVRLTNYNGDTVTSAVDVTNLYLVAFSANGNSYFFKDATELQKSNLFLGTTQHTLSFTGNYDNLETAAGTRRESIELGPNPLDGAITSLWYDGGVARSLLVLIQMVPEAARFRYIEQEVRRSLQQLTSFTPNALMLSMENNWSSMSLEVQLSGDNVSPFSGTVQLQNYDHTPRLVDNFEELYKITGIAILLFRCVAT 1tx0 A 2.15 BS01 PT1 A 1 N120 I122 M145 D184 F189 G216 K220 S221 R254 N111 I113 M136 D175 F180 G207 K211 S212 R245 V28 D54 K220 R254 V27 D53 K211 R245 2.5.1.15 0004156,0005829,0009396,0016740,0042558,0044237,0046654,0046656,0046872 Q81VW8 15341734 283 KWDYDLRCGEYTLNLNEKTLIMGILNVTPDSFSDGGSYNEVDAAVRHAKEMRDEGAHIIDIGGKVSVEEEIKRVVPMIQAVSKEVKLPISIDTYKAEVAKQAIEAGAHIINDIWGAKAEPKIAEVAAHYDVPIILMHNRDNMNYRNLMADMIADLYDSIKIAKDAGVRDENIILDPGIGFAKTPEQNLEAMRNLEQLNVLGYPVLLGTSRKSFIGHVLDLPVEERLEGTGATVCLGIEKGCEFVRVHDVKEMSRMAKMMDAMIGK 1tx0 B 2.15 BS01 PT1 B 1 N120 M145 D184 F189 G216 K220 S221 R254 N107 M132 D171 F176 G203 K207 S208 R241 V28 D54 K220 R254 V27 D50 K207 R241 2.5.1.15 0004156,0005829,0009396,0016740,0042558,0044237,0046654,0046656,0046872 Q81VW8 15341734 283 KWDYDLRCGEYTLNLNEKTLIMGILNVTPSDGGSYNEVDAAVRHAKEMRDEGAHIIDIGGVSVEEEIKRVVPMIQAVSKEVKLPISIDTYKAEVAKQAIEAGAHIINDIWGAKAEPKIAEVAAHYDVPIILMHNRDNMNYRNLMADMIADLYDSIKIAKDAGVRDENIILDPGIGFAKTPEQNLEAMRNLEQLNVLGYPVLLGTSRKSFIGHVLDLPVEERLEGTGATVCLGIEKGCEFVRVHDVKEMSRMAKMMDAMIGK 3tr9 A 1.895 BS01 PT1 A 1 F41 D111 N130 Q132 M154 D199 Q204 Y207 K238 S239 R272 F30 D95 N114 Q116 M138 D183 Q188 Y191 K222 S223 R256 K238 R272 K222 R256 2.5.1.15 0004156,0005829,0009396,0016740,0042558,0044237,0046654,0046656,0046872 Q83BY6 26033498 1001 SFHLRLRDDKRIVFSEPAVMGIINVSPNSFYHPHLDLNSALRTAEKMVDEGADILDIGGEATNPFVSPSTQIELDRLLPVIDAIKKRFPQLISVDTSRPRVMREAVNTGADMINDQRALQLDDALTTVSALKTPVCLMHFPSETRKPGSTTHFYFLQSVKKELQESIQRCKKAGISEDRIIIDPGFGQGNYGKNVSENFYLLNKLPEFVAMGLPVLSGWSRKSMIGDVLNQPPENRLFGSIAADVLAVYHGASIIRTHDVKATREAIKIATYTRSVD 3tr9 B 1.895 BS01 PT1 B 1 F41 D111 N130 Q132 M154 D199 Q204 Y207 K238 S239 R272 F30 D88 N107 Q109 M131 D176 Q181 Y184 K215 S216 R249 K238 R272 K215 R249 2.5.1.15 0004156,0005829,0009396,0016740,0042558,0044237,0046654,0046656,0046872 Q83BY6 26033498 1001 SFHLRLRDDKRIVFSEPAVMGIINVSPNSFYHPHLDLNSALRTAEKMVDEGADILDIGGEPSTQIELDRLLPVIDAIKKRFPQLISVDTSRPRVMREAVNTGADMINDQRALQLDDALTTVSALKTPVCLMHFPSETRKPGSTTHFYFLQSVKKELQESIQRCKKAGISEDRIIIDPGFGQGNYGKNVSENFYLLNKLPEFVAMGLPVLSGWSRKSMIGDVLNQPPENRLFGSIAADVLAVYHGASIIRTHDVKATREAIKIATYTRSVD 3tr9 C 1.895 BS01 PT1 C 1 F41 D111 N130 Q132 M154 D199 Y207 K238 S239 R272 F31 D88 N107 Q109 M131 D176 Y184 K215 S216 R249 K238 R272 K215 R249 2.5.1.15 0004156,0005829,0009396,0016740,0042558,0044237,0046654,0046656,0046872 Q83BY6 26033498 1001 QSFHLRLRDDKRIVFSEPAVMGIINVSPNSFYHPHLDLNSALRTAEKMVDEGADILDIGGESTQIELDRLLPVIDAIKKRFPQLISVDTSRPRVMREAVNTGADMINDQRALQLDDALTTVSALKTPVCLMHFPSETRKPGSTTHFYFLQSVKKELQESIQRCKKAGISEDRIIIDPGFGQGNYGKNVSENFYLLNKLPEFVAMGLPVLSGWSRKSMIGDVLNQPPENRLFGSIAADVLAVYHGASIIRTHDVKATREAIKIATYTRSV 3tr9 D 1.895 BS01 PT1 D 1 P75 D111 N130 Q132 M154 D199 Y207 K238 S239 R272 P64 D93 N112 Q114 M136 D181 Y189 K220 S221 R254 K238 R272 K220 R254 2.5.1.15 0004156,0005829,0009396,0016740,0042558,0044237,0046654,0046656,0046872 Q83BY6 26033498 1001 SFHLRLRDDKRIVFSEPAVMGIINVSPNSFYHPHLDLNSALRTAEKMVDEGADILDIGGEATNPFVSTQIELDRLLPVIDAIKKRFPQLISVDTSRPRVMREAVNTGADMINDQRALQLDDALTTVSALKTPVCLMHFPSETRKPGSTTHFYFLQSVKKELQESIQRCKKAGISEDRIIIDPGFGQGNYGKNVSENFYLLNKLPEFVAMGLPVLSGWSRKSMIGDVLNQPPENRLFGSIAADVLAVYHGASIIRTHDVKATREAIKIATYTRSVD 3tyu A 2.7 BS01 PT1 A 1 N115 I117 D185 F190 K221 S222 R255 N109 I111 D175 F180 K211 S212 R245 K221 R255 K211 R245 2.5.1.15 0004156,0005829,0009396,0016740,0042558,0044237,0046654,0046656,0046872 A0A2S9PLG4 22383850 301 MHLTARGLTLDLSRPQVMGILNVTPDSHNNLDQALQHAQRMLSAGATLIDIGGESTRPGAAEVSEQEELDRVVPVVEALAQRFDVWLSVDTSKAAVITESAHAGAHLINDIRSLQEPGALEAAAKTGLPVCLMHMQGMQHSPYYDDLMTDINRFFQHHIERCVAAGIAKNKLLLDPGFGFGKNLAHNYQLLAHLSELHHFELPLLVGMSRKSMVGQLLNVPPQQRVIGSVACAVIAAMQGAQIIRVHDVKETVEAMCIVEATRSA 3tyu B 2.7 BS01 PT1 B 1 N115 D185 G189 F190 K221 S222 R255 N90 D147 G151 F152 K183 S184 R217 K221 R255 K183 R217 2.5.1.15 0004156,0005829,0009396,0016740,0042558,0044237,0046654,0046656,0046872 A0A2S9PLG4 22383850 302 SHMHLTARGLTLDLSRPQVMGILNNNLDQALQHAQRMLSAGATLIDIGELDRVVPVVEALAQRFDVWLSVDTSKAAVITESAHAGAHLINDIRSLQEPGALEAAAKTGLPVCLMHMQDLMTDINRFFQHHIERCVAAGIAKNKLLLDPGFGFGKNLAHNYQLLAHLSELHHFELPLLVGMSRKSMVGQLLNVPPQQRVIGSVACAVIAAMQGAQIIRVHDVKETVEAMCIVEATRSAK 5u10 A 2.04 BS02 PT1 A 1 T62 D96 N115 M139 D185 F190 G217 K221 S222 R255 T55 D89 N108 M132 D178 F183 G210 K214 S215 R248 2.5.1.15 0004156,0005737,0005829,0009396,0009410,0016740,0042558,0044237,0046654,0046656,0046872 P0AC13 29171692 302 MKLFAQGTSLDLSHPHVMGILNVTPDSNSLIDAVKHANLMINAGATIIDVGGESTRPGAAEVSVEEELQRVIPVVEAIAQRFEVWISVDTSKPEVIRESAKVGAHIINDIRSLSEPGALEAAAETGLPVCLMHMQGNPKTMQEAPKYDDVFAEVNRYFIEQIARCEQAGIAKEKLLLDPGFGFGKNLSHNYSLLARLAEFHHFNLPLLVGMSRKSMIGQLLNVGPSERLSGSLACAVIAAMQGAHIIRVHDVKETVEAMRVVEATLSAKENKRYE 5u10 B 2.04 BS02 PT1 B 1 T62 N115 I117 M139 D185 F190 G217 K221 S222 R255 T52 N105 I107 M129 D166 F171 G198 K202 S203 R236 2.5.1.15 0004156,0005737,0005829,0009396,0009410,0016740,0042558,0044237,0046654,0046656,0046872 P0AC13 29171692 302 SMKLFAQGTSLDLSHPHVMGILNVNSLIDAVKHANLMINAGATIIDVGGESTRPGAAEVSVEEELQRVIPVVEAIAQRFEVWISVDTSKPEVIRESAKVGAHIINDIRSLSEPGALEAAAETGLPVCLMHMQPKYDDVFAEVNRYFIEQIARCEQAGIAKEKLLLDPGFGFGKNLSHNYSLLARLAEFHHFNLPLLVGMSRKSMIGQLLNVGPSERLSGSLACAVIAAMQGAHIIRVHDVKETVEAMRVVEATLSAKENKRYE 6jwr A 2.6 BS01 PT1 A 1 P438 D482 N502 I504 M529 D575 G579 F580 F603 G605 K609 R610 R686 P328 D364 N384 I386 M411 D457 G461 F462 F485 G487 K491 R492 R529 2.5.1.15,2.7.6.3 0003848,0004156,0005524,0005740,0009396,0016301,0016310,0042558,0044237,0046654,0046656,0046872 Q25704 31883412 801 IQELILSEENKTNIAVLNLGTNDRRNAVLILETALHLVEKYLGKIINTSYLYETVPEYIVLDDVNYINELMQNLEESKYEENKELIDKCEEYETFLKNGKVDNSILKEVNVENYLLECNNIIVKNDEIMKNNTSYFYNLTVVVKTFVNDPLSMLVVIKYIEELMKIIDIDILFFNDFTIFMKNIKLEKNMIYKILSKYIHLEIINNMVDNIEFLSIPHVYTTHRYSILLCLNDMIPEYKHNVLNNTIRCLYNKYVSRMKEQYNINIKENNKRIYVLKDRISYLKEKTNIVGILNVNIFVEPKRAVQRMFEMINEGASVIDIGGESSAPFVIPNPKISERDLVVPVLQLFQKEWNDIAKPIISIDTINYNVFKECVDNDLVDILNDISACTNNPEIIKLLKKKNKFYSVVLMHKRGNPHTMDKLTNYDNLVYDIKNYLEQRLNFLVLNGIPRYRILFDIGLGFAKKHDQSIKLLQNIHVYDEYPLFIGYSRKRFIAHCMNDKDQLLYQKNICGGLAIASYSYYKKVDLIRVHDVLETKSVLDVLTKIDQV 6jwr B 2.6 BS01 PT1 B 1 S436 A437 P438 D482 N502 I504 M529 D575 F580 G605 K609 R610 R686 S312 A313 P314 D349 N369 I371 M396 D442 F447 G472 K476 R477 R513 2.5.1.15,2.7.6.3 0003848,0004156,0005524,0005740,0009396,0016301,0016310,0042558,0044237,0046654,0046656,0046872 Q25704 31883412 801 LSEENKTNIAVLNLGTNDRRNAVLILETALHLVEKYLGKIINTSYLYETVPEYINYINELMQNLEESKYEENKELIDKCEEYETFLKNGKVDNSILKEVNVENYLLECNNIIVKNDEIMKNSYFYNLTVVVKTFVNDPLSMLVVIKYIEELMKIIDIDILFFNDFTIFMKNIYKILSKYIHLDPQEIINNMVDNIEFLSIPHVYTTHRYSILLCLNDMIPEYKHNVLNNTIRCLYNKYVSRMKEQYNINIKENNKRIYVLKDRISYLKEKTNIVGILNVNYGIFVEPKRAVQRMFEMINEGASVIDIGGESSAPFVIPNPKISERDLVVPVLQLFQKEWNDAKPIISIDTINYNVFKECVDNDLVDILNDISACTNNPEIIKLLKKKNKFYSVVLMHKRGNPHTMDKLTNYDNLVYDIKNYLEQRLNFLVLNGIPRYRILFDIGLGFAKKHDQSIKLLQNIHVYDEYPLFIGYSRKRFIAHCMDKDQLLYQKNICGGLAIASYSYYKKVDLIRVHDVLETKSVLDVLTKIDQVKDPNSSSVDKLAAALE 6jws A 2.3 BS01 PT1 A 1 S436 G437 P438 D482 N502 I504 M529 D575 F580 G605 K609 R610 R686 S317 G318 P319 D363 N383 I385 M410 D456 F461 G486 K490 R491 R529 2.5.1.15,2.7.6.3 0003848,0004156,0005524,0005740,0009396,0016301,0016310,0042558,0044237,0046654,0046656,0046872 Q25704 31883412 801 QELILSEENKTNIAVLNLGTNDRRNAVLILETALHLVEKYLGKIINTSYLYETVPVNYINELMQNLEESKYEENKELIDKCEEYETFLKNGKVDNSILKEVNVENYLLECNNIIVKNDEIMKSYFYNLTVVVKTFVNDPLSMLVVIKYIEELMKIIDIDILFFNDFTIFMKNIKLEKNMIYKILSKYIHLEDPQEIINNMVDNIEFLSIPHVYTTHRYSILLCLNDMIPEYKHNVLNNTIRCLYNKYVSRMKEQYNINIKENNKRIYVLKDRISYLKEKTNIVGILNVNVEPKRAVQRMFEMINEGASVIDIGGESSGPFVIPNPKISERDLVVPVLQLFQKEWNDIKNKIVKCDAKPIISIDTINYNVFKECVDNDLVDILNDISACTNNPEIIKLLKKKNKFYSVVLMHKRGNPHTMDKLTNYDNLVYDIKNYLEQRLNFLVLNGIPRYRILFDIGLGFAKKHDQSIKLLQNIHVYDEYPLFIGYSRKRFIAHCMNDDKDQLLYQKNICGGLAIASYSYYKKVDLIRVHDVLETKSVLDVLTKIDQVKD 6jws B 2.3 BS01 PT1 B 1 G437 P438 D482 N502 M529 D575 F580 G605 K609 R610 R686 G331 P332 D376 N396 M423 D469 F474 G499 K503 R504 R553 2.5.1.15,2.7.6.3 0003848,0004156,0005524,0005740,0009396,0016301,0016310,0042558,0044237,0046654,0046656,0046872 Q25704 31883412 801 QELILSEENKTNIAVLNLGTNDRRNAVLILETALHLVEKYLGKIINTSYLYETVPEYIVNYINELMQNLEESKYEENKELIDKCEEYETFLKNGKVDNSILKEVNVENYLLECNNIIVKNDEIMKNSYFYNLTVVVKTFVNDPLSMLVVIKYIEELMKIIDIDILFFNDFTIFMKNIKLEKNMIYKILSKYIHLEPQEIINNMVDNIEFLSIPHVYTTHRYSILLCLNDMIPEYKHNVLNNTIRCLYNKYVSRMKEQYNINIKENNKRIYVLKDRISYLKEKTNIVGILNVNYDSFSDGGIFVEPKRAVQRMFEMINEGASVIDIGGESSGPFVIPNPKISERDLVVPVLQLFQKEWNDIKNKIVKCDAKPIISIDTINYNVFKECVDNDLVDILNDISACTNNPEIIKLLKKKNKFYSVVLMHKRGNPHTMDKLTNYDNLVYDIKNYLEQRLNFLVLNGIPRYRILFDIGLGFAKKHDQSIKLLQNIHVYDEYPLFIGYSRKRFIAHCMNHNWMFQMNYMRKDKDQLLYQKNICGGLAIASYSYYKKVDLIRVHDVLETKSVLDVLTKIDQVKDPNSSSVDKLAAALE 6jwt A 2.56 BS03 PT1 A 1 G437 P438 D482 N502 I504 M529 D575 G579 F580 G605 K609 R610 R686 G316 P317 D361 N381 I383 M408 D454 G458 F459 G484 K488 R489 R526 2.5.1.15,2.7.6.3 0003848,0004156,0005524,0005740,0009396,0016301,0016310,0042558,0044237,0046654,0046656,0046872 Q25704 31883412 804 LILSEENKTNIAVLNLGTNDRRNAVLILETALHLVEKYLGKIINTSYLYETVPVNYINELMQNLEESKYEENKELIDKCEEYETFLKNGKVDNSILKEVNVENYLLECNNIIVKNDESYFYNLTVVVKTFVNDPLSMLVVIKYIEELMKIIDIDILFFNDFTIFMKNIKLEKNMIYKILSKYIHLERFRDPQEIINNMVDNIEFLSIPHVYTTHRYSILLCLNDMIPEYKHNVLNNTIRCLYNKYVSRMKEQYNINIKENNKRIYVLKDRISYLKEKTNIVGILNVNVEPKRAVQRMFEMINEGASVIDIGGESFGPFVIPNPKISERDLVVPVLQLFQKEWNDIKNKIVKCDAKPIISIDTINYNVFKECVDNDLVDILNDISACTNNPEIIKLLKKKNKFYSVVLMHKRGNPHTMDKLTNYDNLVYDIKNYLEQRLNFLVLNGIPRYRILFDIGLGFAKKHDQSIKLLQNIHVYDEYPLFIGYSRKRFITHCMNDKDQLLYQKNICGGLAIASYSYYKKVDLIRVHDVLETKSVLDVLTKIDQVKD 6jwt B 2.56 BS03 PT1 B 1 G437 P438 D482 N502 I504 M529 D575 F580 G605 K609 R610 R686 G326 P327 D371 N391 I393 M418 D464 F469 G494 K498 R499 R535 2.5.1.15,2.7.6.3 0003848,0004156,0005524,0005740,0009396,0016301,0016310,0042558,0044237,0046654,0046656,0046872 Q25704 31883412 803 ELILSEENKTNIAVLNLGTNDRRNAVLILETALHLVEKYLGKIINTSYLYETVPYINELMQNLEESKYEENKELIDKCEEYETFLKNGKVDNSILKEVNVENYLLECNNIIVKNDEIMKNSYFYNLTVVVKTFVNDPLSMLVVIKYIEELMKIIDIDILFFNDFTIFMKNIKLEKNMIYKILSKYIHLEDPQEIINNMVDNIEFLSIPHVYTTHRYSILLCLNDMIPEYKHNVLNNTIRCLYNKYVSRMKEQYNINIKENNKRIYVLKDRISYLKEKTNIVGILNVNYDSFSDGGIFVEPKRAVQRMFEMINEGASVIDIGGESFGPFVIPNPKISERDLVVPVLQLFQKEWNDIKNKIVKCDAKPIISIDTINYNVFKECVDNDLVDILNDISACTNNPEIIKLLKKKNKFYSVVLMHKRGNPHTMDKLTNYDNLVYDIKNYLEQRLNFLVLNGIPRYRILFDIGLGFAKKHDQSIKLLQNIHVYDEYPLFIGYSRKRFITHCMNKDQLLYQKNICGGLAIASYSYYKKVDLIRVHDVLETKSVLDVLTKIDQVKDPNSSSVDKLAAALE 6pz2 A 2.0 BS01 PT1 A 1 T55 P57 N108 V110 M133 D173 G177 F178 G205 K209 S210 R243 T55 P57 N108 V110 M133 D173 G177 F178 G205 K209 S210 R243 0004156,0009396,0042558,0044237 310 MFDYGKRTYIMGILNVTPDSFSDGGDFNNLDIAIQHAKDMVDQGADIIDLGGESTRPGHSYVDSDEELRRVIPVIKKLKQELDIPISIDTYKADVAEEALKLGVTMVNDVWGLRKDKNMASVIGKYDAEVCIMHNQDGTNYDKDIMESIKDFFKVSIEMAMSCGVKKEKIVLDPGVGFGKDFEQNIEVLRRLNELKDLGYPILLGTSRKSVIGKVLPVEPKKRLEGTIATTVLGIRDGVDIVRVHDVYENLMAARMTDAIYRK 8d5i A 1.82 BS01 PT1 A 1 T51 G52 D86 N105 V107 M130 F141 D177 G182 F183 S211 K215 S216 R249 T51 G52 D86 N105 V107 M130 F141 D177 G182 F183 S211 K215 S216 R249 0004156,0009396,0042558,0044237 301 MAKVKIVGILNVTPNSFHDGGRFVETDKAVVRARELLSQGADIIEIGGESTGPGSNTITADEELARIVPVIRAIRSSLPDANIAVDTYKAEVARKALELGATMINDVSAGRADPKLFGVVARSNAQIVLMYSKDTDPHTSFDERQYVDVVRTVYDFLAERKKAAMSAGIPADRIILDTGLGGFVSSDPQYSFQLLAHLSDFQDLGCKLFLSPSRKSFLAGNELLKTADRLPGTIAASAIAVLHGADYIRTHDVLEVRRGCEIATAINQPP 8d5i B 1.82 BS02 PT1 B 1 T51 G52 D86 N105 V107 M130 F141 D177 G181 G182 F183 F209 S211 K215 S216 R249 T51 G52 D86 N105 V107 M130 F141 D177 G181 G182 F183 F209 S211 K215 S216 R249 0004156,0009396,0042558,0044237 302 MAKVKIVGILNVTPNSFHDGGRFVETDKAVVRARELLSQGADIIEIGGESTGPGSNTITADEELARIVPVIRAIRSSLPDANIAVDTYKAEVARKALELGATMINDVSAGRADPKLFGVVARSNAQIVLMYSKDTDPHTSFDERQYVDVVRTVYDFLAERKKAAMSAGIPADRIILDTGLGGFVSSDPQYSFQLLAHLSDFQDLGCKLFLSPSRKSFLAGNELLKTADRLPGTIAASAIAVLHGADYIRTHDVLEVRRGCEIATAINQPP