1bux A 2.8 BS01 PPS A 1 K16 Y56 R62 F64 L68 T98 H122 K11 Y51 R57 F59 L63 T93 H117 K16 Y56 N119 H122 E133 K11 Y51 N114 H117 E128 2.7.4.6 0004550,0005524,0005737,0005840,0005856,0005886,0006183,0006187,0006228,0006241,0006414,0007186,0009117,0009142,0009617,0015629,0016301,0016310,0019954,0030036,0030141,0045335,0045920,0046872,0048550,0050765 -logKd/Ki=4.85, Kd=14uM P22887 9786875 160 VNKERTFLAVKPDGVARGLVGEIIARYEKKGFVLVGLKQLVPTKDLAESHYAEHKERPFFGGLVSFITSGPVVAMVFEGKGVVASARLMIGVTNPLASAPGSIRGDFGVDVGRNIIHGSDSVESANREIALWFKPEELLTEVKPNPNLYE 1bux B 2.8 BS01 PPS B 1 Y56 H59 F64 L68 T98 V116 N119 H122 Y51 H54 F59 L63 T93 V111 N114 H117 K16 Y56 N119 H122 E133 K11 Y51 N114 H117 E128 2.7.4.6 0004550,0005524,0005737,0005840,0005856,0005886,0006183,0006187,0006228,0006241,0006414,0007186,0009117,0009142,0009617,0015629,0016301,0016310,0019954,0030036,0030141,0045335,0045920,0046872,0048550,0050765 -logKd/Ki=4.85, Kd=14uM P22887 9786875 160 VNKERTFLAVKPDGVARGLVGEIIARYEKKGFVLVGLKQLVPTKDLAESHYAEHKERPFFGGLVSFITSGPVVAMVFEGKGVVASARLMIGVTNPLASAPGSIRGDFGVDVGRNIIHGSDSVESANREIALWFKPEELLTEVKPNPNLYE 1bux C 2.8 BS01 PPS C 1 K16 Y56 F64 L68 V116 H122 K11 Y51 F59 L63 V111 H117 K16 Y56 N119 H122 E133 K11 Y51 N114 H117 E128 2.7.4.6 0004550,0005524,0005737,0005840,0005856,0005886,0006183,0006187,0006228,0006241,0006414,0007186,0009117,0009142,0009617,0015629,0016301,0016310,0019954,0030036,0030141,0045335,0045920,0046872,0048550,0050765 P22887 9786875 160 VNKERTFLAVKPDGVARGLVGEIIARYEKKGFVLVGLKQLVPTKDLAESHYAEHKERPFFGGLVSFITSGPVVAMVFEGKGVVASARLMIGVTNPLASAPGSIRGDFGVDVGRNIIHGSDSVESANREIALWFKPEELLTEVKPNPNLYE 1hy3 A 1.8 BS01 PPS A 1 K47 G49 T50 T51 W52 K105 H107 R129 S137 Y192 F228 F254 M255 R256 K257 G258 K46 G48 T49 T50 W51 K104 H106 R128 S136 Y191 F227 F251 M252 R253 K254 G255 K47 H107 S137 K46 H106 S136 2.8.2.4 0004062,0004304,0005496,0005515,0005737,0005829,0006068,0006629,0006711,0008146,0008202,0008210,0016740,0031965,0045600,0047894,0050294,0050427,0051923 P49888 11884392 602 NSELDYYEKFEEVHGILMYKDFVKYWDNVEAFQARPDDLVIATYPKSGTTWVSEIVYMIYKEGDVEKCKEDVIFNRIPFLECRKENLMNGVKQLDEMNSPRIVKTHLPPELLPASFWEKDCKIIYLCRNAKDVAVSFYYFFLMVAGHPNPGSFPEFVEKFMQGQVPYGSWYKHVKSWWEKGKSPRVLFLFYEDLKEDIRKEVIKLIHFLERKPSEELVDRIIHHTSFQEMKNNPSTNYTTLPDEIMNQKPFMRKGITGDWKNHFTEALNEKFDKHYEQQMKESTLKF 1hy3 B 1.8 BS01 PPS B 1 K47 G49 T50 T51 W52 K105 H107 R129 S137 Y192 F254 M255 R256 K257 G258 K45 G47 T48 T49 W50 K103 H105 R127 S135 Y190 F252 M253 R254 K255 G256 K47 H107 S137 K45 H105 S135 2.8.2.4 0004062,0004304,0005496,0005515,0005737,0005829,0006068,0006629,0006711,0008146,0008202,0008210,0016740,0031965,0045600,0047894,0050294,0050427,0051923 P49888 11884392 502 SELDYYEKFEEVHGILMYKDFVKYWDNVEAFQARPDDLVIATYPKSGTTWVSEIVYMIYKEGDVEKCKEDVIFNRIPFLECRKENLMNGVKQLDEMNSPRIVKTHLPPELLPASFWEKDCKIIYLCRNAKDVAVSFYYFFLMVAGHPNPGSFPEFVEKFMQGQVPYGSWYKHVKSWWEKGKSPRVLFLFYEDLKEDIRKEVIKLIHFLERKPSEELVDRIIHHTSFQEMKNNPSTNYTTLPDEIMNQKLSPFMRKGITGDWKNHFTEALNEKFDKHYEQQMKESTLKF 1m8p A 2.6 BS01 PPS A 1 D434 R437 F446 R451 N454 I477 P479 R515 G528 F529 D434 R437 F446 R451 N454 I477 P479 R515 G528 F529 T198 R199 H203 H206 R292 T198 R199 H203 H206 R292 2.7.7.4 0000103,0004020,0004781,0005524 Q12650 12426581 574 MANAPHGGVLKDLLARDAPRQAELAAEAESLPAVTLTERQLCDLELIMNGGFSPLEGFMNQADYDRVCEDNRLADGNVFSMPITLDASQEVIDEKKLQAASRITLRDFRDDRNLAILTIDDIYRPDKTKEAKLVFGGDPEHPAIVYLNNTVKEFYIGGKIEAVNKLNHYDYVALRYTPAELRVHFDKLGWSRVVAFQTRNPMHRAHRELTVRAARSRQANVLIHPVVGLTKPGDIDHFTRVRAYQALLPRYPNGMAVLGLLGLAMRMGGPREAIWHAIIRKNHGATHFIVGRDHAGPGSNSKGEDFYGPYDAQHAVEKYKDELGIEVVEFQMVTYLPDTDEYRPVDQVPAGVKTLNISGTELRRRLRSGAHIPEWFSYPEVVKILRESNPPRATQGFTIFLTGYMNSGKDAIARALQVTLNQQGGRSVSLLLGDTVRHELSSELGFTREDRHTNIQRIAFVATELTRAGAAVIAAPIAPYEESRKFARDAVSQAGSFFLVHVATPLEHCEQSDKRGIYAAARRGEIKGFTGVDDPYETPEKADLVVDFSKQSVRSIVHEIILVLESQGFLERQ 1m8p B 2.6 BS01 PPS B 1 M405 R437 F446 R451 N454 P476 I477 A478 P479 R515 G528 F529 T530 M405 R437 F446 R451 N454 P476 I477 A478 P479 R515 G528 F529 T530 T198 R199 H203 H206 R292 T198 R199 H203 H206 R292 2.7.7.4 0000103,0004020,0004781,0005524 Q12650 12426581 575 MANAPHGGVLKDLLARDAPRQAELAAEAESLPAVTLTERQLCDLELIMNGGFSPLEGFMNQADYDRVCEDNRLADGNVFSMPITLDASQEVIDEKKLQAASRITLRDFRDDRNLAILTIDDIYRPDKTKEAKLVFGGDPEHPAIVYLNNTVKEFYIGGKIEAVNKLNHYDYVALRYTPAELRVHFDKLGWSRVVAFQTRNPMHRAHRELTVRAARSRQANVLIHPVVGLTKPGDIDHFTRVRAYQALLPRYPNGMAVLGLLGLAMRMGGPREAIWHAIIRKNHGATHFIVGRDHAGPGSNSKGEDFYGPYDAQHAVEKYKDELGIEVVEFQMVTYLPDTDEYRPVDQVPAGVKTLNISGTELRRRLRSGAHIPEWFSYPEVVKILRESNPPRATQGFTIFLTGYMNSGKDAIARALQVTLNQQGGRSVSLLLGDTVRHELSSELGFTREDRHTNIQRIAFVATELTRAGAAVIAAPIAPYEESRKFARDAVSQAGSFFLVHVATPLEHCEQSDKRGIYAAARRGEIKGFTGVDDPYETPEKADLVVDFSKQSVRSIVHEIILVLESQGFLERQ 1m8p C 2.6 BS01 PPS C 1 D434 R437 F446 R451 N454 P476 I477 P479 R515 G528 F529 D434 R437 F446 R451 N454 P476 I477 P479 R515 G528 F529 T198 R199 H203 H206 R292 T198 R199 H203 H206 R292 2.7.7.4 0000103,0004020,0004781,0005524 Q12650 12426581 576 MANAPHGGVLKDLLARDAPRQAELAAEAESLPAVTLTERQLCDLELIMNGGFSPLEGFMNQADYDRVCEDNRLADGNVFSMPITLDASQEVIDEKKLQAASRITLRDFRDDRNLAILTIDDIYRPDKTKEAKLVFGGDPEHPAIVYLNNTVKEFYIGGKIEAVNKLNHYDYVALRYTPAELRVHFDKLGWSRVVAFQTRNPMHRAHRELTVRAARSRQANVLIHPVVGLTKPGDIDHFTRVRAYQALLPRYPNGMAVLGLLGLAMRMGGPREAIWHAIIRKNHGATHFIVGRDHAGPGSNSKGEDFYGPYDAQHAVEKYKDELGIEVVEFQMVTYLPDTDEYRPVDQVPAGVKTLNISGTELRRRLRSGAHIPEWFSYPEVVKILRESNPPRATQGFTIFLTGYMNSGKDAIARALQVTLNQQGGRSVSLLLGDTVRHELSSELGFTREDRHTNIQRIAFVATELTRAGAAVIAAPIAPYEESRKFARDAVSQAGSFFLVHVATPLEHCEQSDKRGIYAAARRGEIKGFTGVDDPYETPEKADLVVDFSKQSVRSIVHEIILVLESQGFLERQ 2ofx A 1.9 BS03 PPS A 1 S61 K65 D89 R92 F101 R106 N109 F131 I132 S133 P134 K171 L173 G184 F185 T186 S39 K43 D67 R70 F79 R84 N87 F109 I110 S111 P112 K149 L151 G162 F163 T164 2.7.1.25,2.7.7.4 0000103,0004020,0005524 O43252 17276460 1100 HMATNVTYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTVSMALEEYLVCHGIPCYTLDGDNIRQGLNKNLGFSPEDREENVRRIAEVAKLFADAGLVCITSFISPYTQDRNNARQIHEGASLPFFEVFVDAPLHVCEQRDVKGLYKKARAGEIKGFTGIDSEYEKPEAPELVLKTDSCDVNDCVQQVVELLQERDIVP 2ofx A 1.9 BS05 PPS B 1 N27 V28 N5 V6 2.7.1.25,2.7.7.4 0000103,0004020,0005524 O43252 17276460 1200 HMATNVTYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTVSMALEEYLVCHGIPCYTLDGDNIRQGLNKNLGFSPEDREENVRRIAEVAKLFADAGLVCITSFISPYTQDRNNARQIHEGASLPFFEVFVDAPLHVCEQRDVKGLYKKARAGEIKGFTGIDSEYEKPEAPELVLKTDSCDVNDCVQQVVELLQERDIVP 2ofx B 1.9 BS02 PPS B 1 S61 G88 D89 R92 F101 R106 N109 F131 I132 S133 P134 K171 L173 G184 F185 T186 S39 G66 D67 R70 F79 R84 N87 F109 I110 S111 P112 K149 L151 G162 F163 T164 2.7.1.25,2.7.7.4 0000103,0004020,0005524 O43252 17276460 1200 HMATNVTYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTVSMALEEYLVCHGIPCYTLDGDNIRQGLNKNLGFSPEDREENVRRIAEVAKLFADAGLVCITSFISPYTQDRNNARQIHEGASLPFFEVFVDAPLHVCEQRDVKGLYKKARAGEIKGFTGIDSEYEKPEAPELVLKTDSCDVNDCVQQVVELLQERDIVP 2zyt X 1.55 BS01 PPS X 1 P47 K48 T51 T52 W53 H108 R130 S138 F142 Y193 F229 F255 M256 R257 K258 G259 P44 K45 T48 T49 W50 H105 R127 S135 F139 Y190 F226 F252 M253 R254 K255 G256 2.8.2.- 0000103,0004062,0005737,0006584,0006629,0008146,0016740,0051923 Q3UZZ6 19344693 501 KLDVFRRELVDVEGIPLFWSIAEHWSQVESFEARPDDILISTYPKSGTTWVSEILDLIYNNGDAEKCKRDAIYKRVPFMELIIPGITNGVEMLNNMPSPRIVKTHLPVQLLPSSFWKNDCKIIYVARNAKDVVVSYYYFYQMAKIHPEPGTWEEFLEKFMAGQVSFGPWYDHVKSWWEKRKEYRILYLFYEDMKENPKCEIQKILKFLEKDIPEEILNKILYHSSFSVMKENPSANYTTMMKEEMDHSVSPFMRKGISGDWKNQFTVAQYEKFEEDYVKKMEDSTLKFRSE 2zyu X 1.8 BS01 PPS X 1 P47 K48 G50 T51 T52 W53 K106 H108 R130 S138 F142 Y193 F229 F255 M256 R257 K258 G259 P42 K43 G45 T46 T47 W48 K101 H103 R125 S133 F137 Y188 F224 F250 M251 R252 K253 G254 2.8.2.- 0000103,0004062,0005737,0006584,0006629,0008146,0016740,0051923 Q3UZZ6 19344693 501 DVFRRELVDVEGIPLFWSIAEHWSQVESFEARPDDILISTYPKSGTTWVSEILDLIYNNGDAEKCKRDAIYKRVPFMELIIPGITNGVEMLNNMPSPRIVKTHLPVQLLPSSFWKNDCKIIYVARNAKDVVVSYYYFYQMAKIHPEPGTWEEFLEKFMAGQVSFGPWYDHVKSWWEKRKEYRILYLFYEDMKENPKCEIQKILKFLEKDIPEEILNKILYHSSFSVMKENPSANYTTMMKEEMDHSVSPFMRKGISGDWKNQFTVAQYEKFEEDYVKKMEDSTLKFRSE 2zyv X 1.81 BS01 PPS X 1 P47 K48 T51 T52 W53 H108 R130 S138 F142 Y193 F229 F255 M256 R257 K258 G259 P42 K43 T46 T47 W48 H103 R125 S133 F137 Y188 F224 F250 M251 R252 K253 G254 2.8.2.- 0000103,0004062,0005737,0006584,0006629,0008146,0016740,0051923 Q3UZZ6 19344693 1501 DVFRRELVDVEGIPLFWSIAEHWSQVESFEARPDDILISTYPKSGTTWVSEILDLIYNNGDAEKCKRDAIYKRVPFMELIIPGITNGVEMLNNMPSPRIVKTHLPVQLLPSSFWKNDCKIIYVARNAKDVVVSYYYFYQMAKIHPEPGTWEEFLEKFMAGQVSFGPWYDHVKSWWEKRKEYRILYLFYEDMKENPKCEIQKILKFLEKDIPEEILNKILYHSSFSVMKENPSANYTTMMKEEMDHSVSPFMRKGISGDWKNQFTVAQYEKFEEDYVKKMEDSTLKFRSE 3cr7 A 2.5 BS02 PPS A 1 R66 F75 R80 N83 F105 I106 S107 P108 K151 L153 E164 F165 T166 R43 F52 R57 N60 F82 I83 S84 P85 K122 L124 E135 F136 T137 2.7.1.25 0000103,0004020,0005524,0005829,0009086,0016301,0016310,0019344,0070814 Q12657 2002 RGLTIWLTGLSASGKSTLAVELEHQLVRDRRVHAYRLDGDNIRFGLNKDLGFSEADRNENIRRIAEVAKLFADSNSIAITSFISPYRKDRDTARQLHEVTGLPFVEVYVDVPVEVAEQRDPKGLYKKAREGVIKEFTGISAPYEAPANPEVHVKNYELPVQDAVKQIIDYLDTKGYLPA 3cr7 C 2.5 BS02 PPS C 1 R66 F75 R80 N83 F105 I106 S107 P108 L153 E164 F165 T166 R44 F53 R58 N61 F83 I84 S85 P86 L125 E136 F137 T138 2.7.1.25 0000103,0004020,0005524,0005829,0009086,0016301,0016310,0019344,0070814 Q12657 2005 QRGLTIWLTGLSASGKSTLAVELEHQLVRDRRVHAYRLDGDNIRFGLNKDLGFSEADRNENIRRIAEVAKLFADSNSIAITSFISPYRKDRDTARQLHEVTGLPFVEVYVDVPVEVAEQRDPKGLYKKAREGVIKEFTGISAPYEAPANPEVHVKNYELPVQDAVKQIIDYLDTKGYL 3f3m A 2.4 BS01 PPS A 1 G10 S11 G18 H19 R89 R92 Y99 I128 S129 S130 S131 G10 S11 G18 H19 R84 R87 Y94 I123 S124 S125 S126 H19 R92 S130 H19 R87 S125 2.7.7.3 0003824,0004595,0005524,0005737,0009058,0015937,0016779 P63820 19851003 300 MEHTIAVIPGSFDPITYGHLDIIERSTDRFDEIHVCVLKGTFSLEERMDLIEQSVKHLPNVKVHQFSGLLVDYCEQVGAKTIIRGLRAVSDFEYELRLTSMNKKLNNEIETLYMMSSTNYSFISSSIVKEVAAYRADISEFVPPYVEKALKKKFK 4ifb A 2.3 BS01 PPS A 1 K44 G46 T47 N48 W49 H99 R121 S129 Y184 F220 L245 L246 R247 K248 G249 K43 G45 T46 N47 W48 H98 R120 S128 Y183 F219 L234 L235 R236 K237 G238 K44 H99 S129 K43 H98 S128 2.8.2.14,2.8.2.2 0004027,0005515,0005737,0005829,0006068,0006805,0008146,0008202,0008203,0016042,0016740,0030573,0042403,0047704,0050294,0050427,0050656,0051923 Q06520 302 SDDFLWFEGIAFPTMGFRSETLRKVRDEFVIRDEDVIILTYPKSGTNWLAEILCLMHSKGDAKWIQSVPIWERSPWVESEIGYTALSETESPRLFSSHLPIQLFPKSFFSSKAKVIYLMRNPRDVLVSGYFFWKNMKFIKKPKSWEEYFEWFCQGTVLYGSWFDHIHGWMPMREEKNFLLLSYEELKQDTGRTIEKICQFLGKTLEPEELNLILKNSSFQSMKENKMSNYKAQLLRKGVSGDWKNHFTVAQAEDFDKLFQEKMADLPRELFPWE 4ifb B 2.3 BS01 PPS B 1 P43 K44 G46 T47 N48 W49 H99 R121 S129 Y184 F220 L245 R247 K248 G249 P41 K42 G44 T45 N46 W47 H97 R119 S127 Y182 F218 L232 R234 K235 G236 K44 H99 S129 K42 H97 S127 2.8.2.14,2.8.2.2 0004027,0005515,0005737,0005829,0006068,0006805,0008146,0008202,0008203,0016042,0016740,0030573,0042403,0047704,0050294,0050427,0050656,0051923 Q06520 302 DDFLWFEGIAFPTMGFRSETLRKVRDEFVIRDEDVIILTYPKSGTNWLAEILCLMHSKGDAKWIQSVPIWERSPWVESEIGYTALSETESPRLFSSHLPIQLFPKSFFSSKAKVIYLMRNPRDVLVSGYFFWKNMKFIKKPKSWEEYFEWFCQGTVLYGSWFDHIHGWMPMREEKNFLLLSYEELKQDTGRTIEKICQFLGKTLEPEELNLILKNSSFQSMKENKMSNYAQLLRKGVSGDWKNHFTVAQAEDFDKLFQEKMADLPRELFPWE