1b57 A 2.0 BS04 PGH A 1 D109 H110 H226 G227 H264 G265 S267 N286 I287 D288 T289 D109 H110 H214 G215 H252 G253 S255 N274 I275 D276 T277 D109 H110 E182 H226 H264 N286 D109 H110 E182 H214 H252 N274 4.1.2.13 0004332,0005515,0005829,0005975,0006094,0006096,0008270,0016829,0016832,0042802,0042803,0046872 -logKd/Ki=8.00, Ki=0.01uM P0AB71 10080900 359 SKIFDFVKPGVITGDDVQKVFQVAKENNFALPAVNCVGTDSINAVLETAAKVKAPVIVQFSNGGASFIAGKGVKSDVPQGAAILGAISGAHHVHQMAEHYGVPVILHTDHCAKKLLPWIDGLLDAGEKHFAATGKPLFSSHMIDLSEESLQENIEICSKYLERMSKIGMTLEIELGCTGGEELYTQPEDVDYAYTELSKISPRFTIAASFGNVHGVYKPGNVVLTPTILRDSQEYVSKKHNLPHNSLNFVFHGGSGSTAQEIKDSVSYGVVKMNIDTDTQWATWEGVLNYYKANEAYLQGQLGNPKGEDQPNKKYYDPRVWLRAGQTSMIARLEKAFQELNAIDVL 1b57 B 2.0 BS04 PGH B 1 D109 H110 H226 G227 H264 G265 S267 N286 I287 D288 T289 D109 H110 H214 G215 H252 G253 S255 N274 I275 D276 T277 D109 H110 E182 H226 H264 N286 D109 H110 E182 H214 H252 N274 4.1.2.13 0004332,0005515,0005829,0005975,0006094,0006096,0008270,0016829,0016832,0042802,0042803,0046872 -logKd/Ki=8.00, Ki=0.01uM P0AB71 10080900 359 SKIFDFVKPGVITGDDVQKVFQVAKENNFALPAVNCVGTDSINAVLETAAKVKAPVIVQFSNGGASFIAGKGVKSDVPQGAAILGAISGAHHVHQMAEHYGVPVILHTDHCAKKLLPWIDGLLDAGEKHFAATGKPLFSSHMIDLSEESLQENIEICSKYLERMSKIGMTLEIELGCTGGEELYTQPEDVDYAYTELSKISPRFTIAASFGNVHGVYKPGNVVLTPTILRDSQEYVSKKHNLPHNSLNFVFHGGSGSTAQEIKDSVSYGVVKMNIDTDTQWATWEGVLNYYKANEAYLQGQLGNPKGEDQPNKKYYDPRVWLRAGQTSMIARLEKAFQELNAIDVL 1gt7 A 2.7 BS02 PGH A 1 N29 G30 G31 N32 S75 G76 T115 S116 E117 H141 H143 H212 N29 G30 G31 N32 S75 G76 T115 S116 E117 H141 H143 H212 E117 H141 H143 E171 H212 E117 H141 H143 E171 H212 4.1.2.19 0005737,0005829,0005996,0008994,0016829,0016830,0016832,0019299,0019301,0019323,0042802,0046872 P32169 11976494 300 MQNITQSWFVQGMIKATTDAWLKGWDERNGGNLTLRLDDADIAPYHDNFHQQPRYIPLSQPMPLLANTPFIVTGSGKFFRNVQLDPAANLGIVKVDSDGAGYHILWGLTNEAVPTSELPAHFLSHCERIKATNGKDRVIMHCHATNLIALTYVLENDTAVFTRQLWEGSTECLVVFPDGVGILPWMVPGTDEIGQATAQEMQKHSLVLWPFHGVFGSGPTLDETFGLIDTAEKSAQVLVKVYSMGGMKQTISREELIALGKRFGVTPLASALAL 1gt7 B 2.7 BS02 PGH B 1 N29 G30 G31 N32 S75 G76 T115 S116 E117 H141 H143 H212 N29 G30 G31 N32 S75 G76 T115 S116 E117 H141 H143 H212 E117 H141 H143 E171 H212 E117 H141 H143 E171 H212 4.1.2.19 0005737,0005829,0005996,0008994,0016829,0016830,0016832,0019299,0019301,0019323,0042802,0046872 P32169 11976494 300 MQNITQSWFVQGMIKATTDAWLKGWDERNGGNLTLRLDDADIAPYHDNFHQQPRYIPLSQPMPLLANTPFIVTGSGKFFRNVQLDPAANLGIVKVDSDGAGYHILWGLTNEAVPTSELPAHFLSHCERIKATNGKDRVIMHCHATNLIALTYVLENDTAVFTRQLWEGSTECLVVFPDGVGILPWMVPGTDEIGQATAQEMQKHSLVLWPFHGVFGSGPTLDETFGLIDTAEKSAQVLVKVYSMGGMKQTISREELIALGKRFGVTPLASALAL 1gt7 C 2.7 BS02 PGH C 1 N29 G30 G31 N32 S75 G76 T115 S116 E117 H141 H143 H212 N29 G30 G31 N32 S75 G76 T115 S116 E117 H141 H143 H212 E117 H141 H143 E171 H212 E117 H141 H143 E171 H212 4.1.2.19 0005737,0005829,0005996,0008994,0016829,0016830,0016832,0019299,0019301,0019323,0042802,0046872 P32169 11976494 300 MQNITQSWFVQGMIKATTDAWLKGWDERNGGNLTLRLDDADIAPYHDNFHQQPRYIPLSQPMPLLANTPFIVTGSGKFFRNVQLDPAANLGIVKVDSDGAGYHILWGLTNEAVPTSELPAHFLSHCERIKATNGKDRVIMHCHATNLIALTYVLENDTAVFTRQLWEGSTECLVVFPDGVGILPWMVPGTDEIGQATAQEMQKHSLVLWPFHGVFGSGPTLDETFGLIDTAEKSAQVLVKVYSMGGMKQTISREELIALGKRFGVTPLASALAL 1gt7 D 2.7 BS02 PGH D 1 N29 G30 G31 N32 S75 G76 T115 S116 E117 H141 H143 H212 N29 G30 G31 N32 S75 G76 T115 S116 E117 H141 H143 H212 E117 H141 H143 E171 H212 E117 H141 H143 E171 H212 4.1.2.19 0005737,0005829,0005996,0008994,0016829,0016830,0016832,0019299,0019301,0019323,0042802,0046872 P32169 11976494 300 MQNITQSWFVQGMIKATTDAWLKGWDERNGGNLTLRLDDADIAPYHDNFHQQPRYIPLSQPMPLLANTPFIVTGSGKFFRNVQLDPAANLGIVKVDSDGAGYHILWGLTNEAVPTSELPAHFLSHCERIKATNGKDRVIMHCHATNLIALTYVLENDTAVFTRQLWEGSTECLVVFPDGVGILPWMVPGTDEIGQATAQEMQKHSLVLWPFHGVFGSGPTLDETFGLIDTAEKSAQVLVKVYSMGGMKQTISREELIALGKRFGVTPLASALAL 1gt7 E 2.7 BS02 PGH E 1 N29 G30 G31 N32 S75 G76 T115 S116 E117 H141 H143 H212 N29 G30 G31 N32 S75 G76 T115 S116 E117 H141 H143 H212 E117 H141 H143 E171 H212 E117 H141 H143 E171 H212 4.1.2.19 0005737,0005829,0005996,0008994,0016829,0016830,0016832,0019299,0019301,0019323,0042802,0046872 P32169 11976494 300 MQNITQSWFVQGMIKATTDAWLKGWDERNGGNLTLRLDDADIAPYHDNFHQQPRYIPLSQPMPLLANTPFIVTGSGKFFRNVQLDPAANLGIVKVDSDGAGYHILWGLTNEAVPTSELPAHFLSHCERIKATNGKDRVIMHCHATNLIALTYVLENDTAVFTRQLWEGSTECLVVFPDGVGILPWMVPGTDEIGQATAQEMQKHSLVLWPFHGVFGSGPTLDETFGLIDTAEKSAQVLVKVYSMGGMKQTISREELIALGKRFGVTPLASALAL 1gt7 F 2.7 BS02 PGH F 1 N29 G30 G31 N32 S75 G76 T115 S116 E117 H141 H143 H212 N29 G30 G31 N32 S75 G76 T115 S116 E117 H141 H143 H212 E117 H141 H143 E171 H212 E117 H141 H143 E171 H212 4.1.2.19 0005737,0005829,0005996,0008994,0016829,0016830,0016832,0019299,0019301,0019323,0042802,0046872 P32169 11976494 300 MQNITQSWFVQGMIKATTDAWLKGWDERNGGNLTLRLDDADIAPYHDNFHQQPRYIPLSQPMPLLANTPFIVTGSGKFFRNVQLDPAANLGIVKVDSDGAGYHILWGLTNEAVPTSELPAHFLSHCERIKATNGKDRVIMHCHATNLIALTYVLENDTAVFTRQLWEGSTECLVVFPDGVGILPWMVPGTDEIGQATAQEMQKHSLVLWPFHGVFGSGPTLDETFGLIDTAEKSAQVLVKVYSMGGMKQTISREELIALGKRFGVTPLASALAL 1gt7 G 2.7 BS02 PGH G 1 N29 G30 G31 N32 S75 G76 T115 S116 E117 H141 H143 H212 N29 G30 G31 N32 S75 G76 T115 S116 E117 H141 H143 H212 E117 H141 H143 E171 H212 E117 H141 H143 E171 H212 4.1.2.19 0005737,0005829,0005996,0008994,0016829,0016830,0016832,0019299,0019301,0019323,0042802,0046872 P32169 11976494 300 MQNITQSWFVQGMIKATTDAWLKGWDERNGGNLTLRLDDADIAPYHDNFHQQPRYIPLSQPMPLLANTPFIVTGSGKFFRNVQLDPAANLGIVKVDSDGAGYHILWGLTNEAVPTSELPAHFLSHCERIKATNGKDRVIMHCHATNLIALTYVLENDTAVFTRQLWEGSTECLVVFPDGVGILPWMVPGTDEIGQATAQEMQKHSLVLWPFHGVFGSGPTLDETFGLIDTAEKSAQVLVKVYSMGGMKQTISREELIALGKRFGVTPLASALAL 1gt7 H 2.7 BS02 PGH H 1 N29 G30 G31 N32 S75 G76 T115 S116 E117 H141 H143 H212 N29 G30 G31 N32 S75 G76 T115 S116 E117 H141 H143 H212 E117 H141 H143 E171 H212 E117 H141 H143 E171 H212 4.1.2.19 0005737,0005829,0005996,0008994,0016829,0016830,0016832,0019299,0019301,0019323,0042802,0046872 P32169 11976494 300 MQNITQSWFVQGMIKATTDAWLKGWDERNGGNLTLRLDDADIAPYHDNFHQQPRYIPLSQPMPLLANTPFIVTGSGKFFRNVQLDPAANLGIVKVDSDGAGYHILWGLTNEAVPTSELPAHFLSHCERIKATNGKDRVIMHCHATNLIALTYVLENDTAVFTRQLWEGSTECLVVFPDGVGILPWMVPGTDEIGQATAQEMQKHSLVLWPFHGVFGSGPTLDETFGLIDTAEKSAQVLVKVYSMGGMKQTISREELIALGKRFGVTPLASALAL 1gt7 I 2.7 BS02 PGH I 1 N29 G30 G31 N32 S75 G76 T115 S116 E117 H141 H143 H212 N29 G30 G31 N32 S75 G76 T115 S116 E117 H141 H143 H212 E117 H141 H143 E171 H212 E117 H141 H143 E171 H212 4.1.2.19 0005737,0005829,0005996,0008994,0016829,0016830,0016832,0019299,0019301,0019323,0042802,0046872 P32169 11976494 300 MQNITQSWFVQGMIKATTDAWLKGWDERNGGNLTLRLDDADIAPYHDNFHQQPRYIPLSQPMPLLANTPFIVTGSGKFFRNVQLDPAANLGIVKVDSDGAGYHILWGLTNEAVPTSELPAHFLSHCERIKATNGKDRVIMHCHATNLIALTYVLENDTAVFTRQLWEGSTECLVVFPDGVGILPWMVPGTDEIGQATAQEMQKHSLVLWPFHGVFGSGPTLDETFGLIDTAEKSAQVLVKVYSMGGMKQTISREELIALGKRFGVTPLASALAL 1gt7 J 2.7 BS02 PGH J 1 N29 G30 G31 N32 S75 G76 T115 S116 E117 H141 H143 H212 N29 G30 G31 N32 S75 G76 T115 S116 E117 H141 H143 H212 E117 H141 H143 E171 H212 E117 H141 H143 E171 H212 4.1.2.19 0005737,0005829,0005996,0008994,0016829,0016830,0016832,0019299,0019301,0019323,0042802,0046872 P32169 11976494 300 MQNITQSWFVQGMIKATTDAWLKGWDERNGGNLTLRLDDADIAPYHDNFHQQPRYIPLSQPMPLLANTPFIVTGSGKFFRNVQLDPAANLGIVKVDSDGAGYHILWGLTNEAVPTSELPAHFLSHCERIKATNGKDRVIMHCHATNLIALTYVLENDTAVFTRQLWEGSTECLVVFPDGVGILPWMVPGTDEIGQATAQEMQKHSLVLWPFHGVFGSGPTLDETFGLIDTAEKSAQVLVKVYSMGGMKQTISREELIALGKRFGVTPLASALAL 1gt7 K 2.7 BS02 PGH K 1 N29 G30 G31 N32 S75 G76 T115 S116 E117 H141 H143 H212 N29 G30 G31 N32 S75 G76 T115 S116 E117 H141 H143 H212 E117 H141 H143 E171 H212 E117 H141 H143 E171 H212 4.1.2.19 0005737,0005829,0005996,0008994,0016829,0016830,0016832,0019299,0019301,0019323,0042802,0046872 P32169 11976494 300 MQNITQSWFVQGMIKATTDAWLKGWDERNGGNLTLRLDDADIAPYHDNFHQQPRYIPLSQPMPLLANTPFIVTGSGKFFRNVQLDPAANLGIVKVDSDGAGYHILWGLTNEAVPTSELPAHFLSHCERIKATNGKDRVIMHCHATNLIALTYVLENDTAVFTRQLWEGSTECLVVFPDGVGILPWMVPGTDEIGQATAQEMQKHSLVLWPFHGVFGSGPTLDETFGLIDTAEKSAQVLVKVYSMGGMKQTISREELIALGKRFGVTPLASALAL 1gt7 L 2.7 BS02 PGH L 1 N29 G30 G31 N32 S75 G76 T115 S116 E117 H141 H143 H212 N29 G30 G31 N32 S75 G76 T115 S116 E117 H141 H143 H212 E117 H141 H143 E171 H212 E117 H141 H143 E171 H212 4.1.2.19 0005737,0005829,0005996,0008994,0016829,0016830,0016832,0019299,0019301,0019323,0042802,0046872 P32169 11976494 300 MQNITQSWFVQGMIKATTDAWLKGWDERNGGNLTLRLDDADIAPYHDNFHQQPRYIPLSQPMPLLANTPFIVTGSGKFFRNVQLDPAANLGIVKVDSDGAGYHILWGLTNEAVPTSELPAHFLSHCERIKATNGKDRVIMHCHATNLIALTYVLENDTAVFTRQLWEGSTECLVVFPDGVGILPWMVPGTDEIGQATAQEMQKHSLVLWPFHGVFGSGPTLDETFGLIDTAEKSAQVLVKVYSMGGMKQTISREELIALGKRFGVTPLASALAL 1gt7 M 2.7 BS02 PGH M 1 N29 G30 G31 N32 S75 G76 T115 S116 E117 H141 H143 H212 N29 G30 G31 N32 S75 G76 T115 S116 E117 H141 H143 H212 E117 H141 H143 E171 H212 E117 H141 H143 E171 H212 4.1.2.19 0005737,0005829,0005996,0008994,0016829,0016830,0016832,0019299,0019301,0019323,0042802,0046872 P32169 11976494 300 MQNITQSWFVQGMIKATTDAWLKGWDERNGGNLTLRLDDADIAPYHDNFHQQPRYIPLSQPMPLLANTPFIVTGSGKFFRNVQLDPAANLGIVKVDSDGAGYHILWGLTNEAVPTSELPAHFLSHCERIKATNGKDRVIMHCHATNLIALTYVLENDTAVFTRQLWEGSTECLVVFPDGVGILPWMVPGTDEIGQATAQEMQKHSLVLWPFHGVFGSGPTLDETFGLIDTAEKSAQVLVKVYSMGGMKQTISREELIALGKRFGVTPLASALAL 1gt7 N 2.7 BS02 PGH N 1 N29 G30 G31 N32 S75 G76 T115 S116 E117 H141 H143 H212 N29 G30 G31 N32 S75 G76 T115 S116 E117 H141 H143 H212 E117 H141 H143 E171 H212 E117 H141 H143 E171 H212 4.1.2.19 0005737,0005829,0005996,0008994,0016829,0016830,0016832,0019299,0019301,0019323,0042802,0046872 P32169 11976494 300 MQNITQSWFVQGMIKATTDAWLKGWDERNGGNLTLRLDDADIAPYHDNFHQQPRYIPLSQPMPLLANTPFIVTGSGKFFRNVQLDPAANLGIVKVDSDGAGYHILWGLTNEAVPTSELPAHFLSHCERIKATNGKDRVIMHCHATNLIALTYVLENDTAVFTRQLWEGSTECLVVFPDGVGILPWMVPGTDEIGQATAQEMQKHSLVLWPFHGVFGSGPTLDETFGLIDTAEKSAQVLVKVYSMGGMKQTISREELIALGKRFGVTPLASALAL 1gt7 O 2.7 BS02 PGH O 1 N29 G30 G31 N32 S75 G76 T115 S116 E117 H141 H143 H212 N29 G30 G31 N32 S75 G76 T115 S116 E117 H141 H143 H212 E117 H141 H143 E171 H212 E117 H141 H143 E171 H212 4.1.2.19 0005737,0005829,0005996,0008994,0016829,0016830,0016832,0019299,0019301,0019323,0042802,0046872 P32169 11976494 300 MQNITQSWFVQGMIKATTDAWLKGWDERNGGNLTLRLDDADIAPYHDNFHQQPRYIPLSQPMPLLANTPFIVTGSGKFFRNVQLDPAANLGIVKVDSDGAGYHILWGLTNEAVPTSELPAHFLSHCERIKATNGKDRVIMHCHATNLIALTYVLENDTAVFTRQLWEGSTECLVVFPDGVGILPWMVPGTDEIGQATAQEMQKHSLVLWPFHGVFGSGPTLDETFGLIDTAEKSAQVLVKVYSMGGMKQTISREELIALGKRFGVTPLASALAL 1gt7 P 2.7 BS02 PGH P 1 N29 G31 N32 S75 G76 T115 S116 E117 H141 H143 H212 N29 G31 N32 S75 G76 T115 S116 E117 H141 H143 H212 E117 H141 H143 E171 H212 E117 H141 H143 E171 H212 4.1.2.19 0005737,0005829,0005996,0008994,0016829,0016830,0016832,0019299,0019301,0019323,0042802,0046872 P32169 11976494 300 MQNITQSWFVQGMIKATTDAWLKGWDERNGGNLTLRLDDADIAPYHDNFHQQPRYIPLSQPMPLLANTPFIVTGSGKFFRNVQLDPAANLGIVKVDSDGAGYHILWGLTNEAVPTSELPAHFLSHCERIKATNGKDRVIMHCHATNLIALTYVLENDTAVFTRQLWEGSTECLVVFPDGVGILPWMVPGTDEIGQATAQEMQKHSLVLWPFHGVFGSGPTLDETFGLIDTAEKSAQVLVKVYSMGGMKQTISREELIALGKRFGVTPLASALAL 1gt7 Q 2.7 BS02 PGH Q 1 N29 G30 G31 N32 S75 G76 T115 S116 E117 H141 H143 H212 N29 G30 G31 N32 S75 G76 T115 S116 E117 H141 H143 H212 E117 H141 H143 E171 H212 E117 H141 H143 E171 H212 4.1.2.19 0005737,0005829,0005996,0008994,0016829,0016830,0016832,0019299,0019301,0019323,0042802,0046872 P32169 11976494 300 MQNITQSWFVQGMIKATTDAWLKGWDERNGGNLTLRLDDADIAPYHDNFHQQPRYIPLSQPMPLLANTPFIVTGSGKFFRNVQLDPAANLGIVKVDSDGAGYHILWGLTNEAVPTSELPAHFLSHCERIKATNGKDRVIMHCHATNLIALTYVLENDTAVFTRQLWEGSTECLVVFPDGVGILPWMVPGTDEIGQATAQEMQKHSLVLWPFHGVFGSGPTLDETFGLIDTAEKSAQVLVKVYSMGGMKQTISREELIALGKRFGVTPLASALAL 1gt7 R 2.7 BS02 PGH R 1 N29 G30 G31 N32 S75 G76 T115 S116 E117 H141 H143 H212 N29 G30 G31 N32 S75 G76 T115 S116 E117 H141 H143 H212 E117 H141 H143 E171 H212 E117 H141 H143 E171 H212 4.1.2.19 0005737,0005829,0005996,0008994,0016829,0016830,0016832,0019299,0019301,0019323,0042802,0046872 P32169 11976494 300 MQNITQSWFVQGMIKATTDAWLKGWDERNGGNLTLRLDDADIAPYHDNFHQQPRYIPLSQPMPLLANTPFIVTGSGKFFRNVQLDPAANLGIVKVDSDGAGYHILWGLTNEAVPTSELPAHFLSHCERIKATNGKDRVIMHCHATNLIALTYVLENDTAVFTRQLWEGSTECLVVFPDGVGILPWMVPGTDEIGQATAQEMQKHSLVLWPFHGVFGSGPTLDETFGLIDTAEKSAQVLVKVYSMGGMKQTISREELIALGKRFGVTPLASALAL 1gt7 S 2.7 BS02 PGH S 1 N29 G30 G31 N32 S75 G76 T115 S116 E117 H141 H143 H212 N29 G30 G31 N32 S75 G76 T115 S116 E117 H141 H143 H212 E117 H141 H143 E171 H212 E117 H141 H143 E171 H212 4.1.2.19 0005737,0005829,0005996,0008994,0016829,0016830,0016832,0019299,0019301,0019323,0042802,0046872 P32169 11976494 300 MQNITQSWFVQGMIKATTDAWLKGWDERNGGNLTLRLDDADIAPYHDNFHQQPRYIPLSQPMPLLANTPFIVTGSGKFFRNVQLDPAANLGIVKVDSDGAGYHILWGLTNEAVPTSELPAHFLSHCERIKATNGKDRVIMHCHATNLIALTYVLENDTAVFTRQLWEGSTECLVVFPDGVGILPWMVPGTDEIGQATAQEMQKHSLVLWPFHGVFGSGPTLDETFGLIDTAEKSAQVLVKVYSMGGMKQTISREELIALGKRFGVTPLASALAL 1gt7 T 2.7 BS02 PGH T 1 N29 G31 N32 S75 G76 T115 S116 E117 H141 H143 H212 N29 G31 N32 S75 G76 T115 S116 E117 H141 H143 H212 E117 H141 H143 E171 H212 E117 H141 H143 E171 H212 4.1.2.19 0005737,0005829,0005996,0008994,0016829,0016830,0016832,0019299,0019301,0019323,0042802,0046872 P32169 11976494 300 MQNITQSWFVQGMIKATTDAWLKGWDERNGGNLTLRLDDADIAPYHDNFHQQPRYIPLSQPMPLLANTPFIVTGSGKFFRNVQLDPAANLGIVKVDSDGAGYHILWGLTNEAVPTSELPAHFLSHCERIKATNGKDRVIMHCHATNLIALTYVLENDTAVFTRQLWEGSTECLVVFPDGVGILPWMVPGTDEIGQATAQEMQKHSLVLWPFHGVFGSGPTLDETFGLIDTAEKSAQVLVKVYSMGGMKQTISREELIALGKRFGVTPLASALAL 1gvf A 1.45 BS01 PGH A 1 D82 H83 H180 G181 H208 G209 S211 N230 V231 A232 T233 D81 H82 H168 G169 H196 G197 S199 N218 V219 A220 T221 D82 H83 H180 H208 N230 D81 H82 H168 H196 N218 4.1.2.40 0005515,0005829,0005975,0008270,0009025,0016829,0016832,0032991,0042802,0046872,0051289,1902494,2001059 P0AB74 11940603 287 SIISTKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALEEIYALCSAYSTTYNMPLALHLDHHESLDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGSAFLTDPQEAKRFVELTGVDSLAVAIGTAHGLYSKTPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAFAGAVKAWFAENPQGNDPRYYMRVGMDAMKEVVRNKINVCGSANRIS 1gvf B 1.45 BS01 PGH B 1 D82 H83 H180 G181 H208 G209 S211 N230 V231 A232 T233 D81 H82 H171 G172 H199 G200 S202 N221 V222 A223 T224 D82 H83 H180 H208 N230 D81 H82 H171 H199 N221 4.1.2.40 0005515,0005829,0005975,0008270,0009025,0016829,0016832,0032991,0042802,0046872,0051289,1902494,2001059 P0AB74 11940603 287 SIISTKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALEEIYALCSAYSTTYNMPLALHLDHHESLDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVESAFLTDPQEAKRFVELTGVDSLAVAIGTAHGLYSKTPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAFAGAVKAWFAENPQGNDPRYYMRVGMDAMKEVVRNKINVCGSANRI 1ik4 A 2.0 BS01 PGH A 1 V17 H19 K23 T45 T47 T48 S65 G66 D71 H98 V17 H19 K23 T45 T47 T48 S65 G66 D71 H98 H19 G66 D71 D91 H98 D101 R107 H19 G66 D71 D91 H98 D101 R107 4.2.3.3 0005737,0005829,0008929,0016829,0019242,0034214,0042802 Ki=39nM -logKd/Ki=7.41, Ki=39nM P0A731 11389594 153 MELTTRTLPARKHIALVAHDHCKQMLMSWVERHQPLLEQHVLYATGTTGNLISRATGMNVNAMLSGPMGGDQQVGALISEGKIDVLIFFWDPLNAVPHDPDVKALLRLATVWNIPVATNVATADFIIQSPHFNDAVDILIPDYQRYLADRLK 1ik4 B 2.0 BS01 PGH B 1 V17 H19 K23 T45 T47 T48 S65 G66 D71 H98 V17 H19 K23 T45 T47 T48 S65 G66 D71 H98 H19 G66 D71 D91 H98 D101 R107 H19 G66 D71 D91 H98 D101 R107 4.2.3.3 0005737,0005829,0008929,0016829,0019242,0034214,0042802 Ki=39nM P0A731 11389594 153 MELTTRTLPARKHIALVAHDHCKQMLMSWVERHQPLLEQHVLYATGTTGNLISRATGMNVNAMLSGPMGGDQQVGALISEGKIDVLIFFWDPLNAVPHDPDVKALLRLATVWNIPVATNVATADFIIQSPHFNDAVDILIPDYQRYLADRL 1ik4 C 2.0 BS01 PGH C 1 V17 H19 K23 T45 T47 T48 S65 G66 D71 H98 V17 H19 K23 T45 T47 T48 S65 G66 D71 H98 H19 G66 D71 D91 H98 D101 R107 H19 G66 D71 D91 H98 D101 R107 4.2.3.3 0005737,0005829,0008929,0016829,0019242,0034214,0042802 Ki=39nM P0A731 11389594 153 MELTTRTLPARKHIALVAHDHCKQMLMSWVERHQPLLEQHVLYATGTTGNLISRATGMNVNAMLSGPMGGDQQVGALISEGKIDVLIFFWDPLNAVPHDPDVKALLRLATVWNIPVATNVATADFIIQSPHFNDAVDILIPDYQRYLADRLK 1ik4 D 2.0 BS01 PGH D 1 V17 H19 K23 T45 T47 T48 S65 G66 D71 H98 V17 H19 K23 T45 T47 T48 S65 G66 D71 H98 H19 G66 D71 D91 H98 D101 R107 H19 G66 D71 D91 H98 D101 R107 4.2.3.3 0005737,0005829,0008929,0016829,0019242,0034214,0042802 Ki=39nM P0A731 11389594 153 MELTTRTLPARKHIALVAHDHCKQMLMSWVERHQPLLEQHVLYATGTTGNLISRATGMNVNAMLSGPMGGDQQVGALISEGKIDVLIFFWDPLNAVPHDPDVKALLRLATVWNIPVATNVATADFIIQSPHFNDAVDILIPDYQRYLADRLK 1ik4 E 2.0 BS01 PGH E 1 V17 H19 K23 T45 T47 T48 S65 G66 D71 H98 V17 H19 K23 T45 T47 T48 S65 G66 D71 H98 H19 G66 D71 D91 H98 D101 R107 H19 G66 D71 D91 H98 D101 R107 4.2.3.3 0005737,0005829,0008929,0016829,0019242,0034214,0042802 Ki=39nM P0A731 11389594 153 MELTTRTLPARKHIALVAHDHCKQMLMSWVERHQPLLEQHVLYATGTTGNLISRATGMNVNAMLSGPMGGDQQVGALISEGKIDVLIFFWDPLNAVPHDPDVKALLRLATVWNIPVATNVATADFIIQSPHFNDAVDILIPDYQRYLADRLK 1ik4 F 2.0 BS01 PGH F 1 V17 H19 K23 T45 T47 T48 S65 G66 D71 H98 V17 H19 K23 T45 T47 T48 S65 G66 D71 H98 H19 G66 D71 D91 H98 D101 R107 H19 G66 D71 D91 H98 D101 R107 4.2.3.3 0005737,0005829,0008929,0016829,0019242,0034214,0042802 Ki=39nM -logKd/Ki=7.41, Ki=39nM P0A731 11389594 153 MELTTRTLPARKHIALVAHDHCKQMLMSWVERHQPLLEQHVLYATGTTGNLISRATGMNVNAMLSGPMGGDQQVGALISEGKIDVLIFFWDPLNAVPHDPDVKALLRLATVWNIPVATNVATADFIIQSPHFNDAVDILIPDYQRYLADRL 1tpb 1 1.9 BS01 PGH 1 1 K13 H95 D165 I170 G171 S211 L230 G232 G233 K10 H92 D162 I167 G168 S208 L227 G229 G230 4.2.3.3,5.3.1.1 0004807,0005737,0005829,0006006,0006094,0006096,0008929,0016829,0016853,0019242,0019563,0019682,0031625,0042803,0046166,0061621 P00940 7577950 250 RKFFVGGNWKMNGDKKSLGELIHTLNGAKLSADTEVVCGAPSIYLDFARQKLDAKIGVAAQNCYKVPKGAFTGEISPAMIKDIGAAWVILGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKAIADNVKDWSKVVLAYDPVWAIGTGKTATPQQAQEVHEKLRGWLKTHVSDAVAQSTRIIYGGSVTGGNCKELASQHDVDGFLVGGASLKPEFVDIINAKH 1tpb 2 1.9 BS01 PGH 2 1 K13 H95 D165 I170 G171 G210 S211 L230 G232 G233 K10 H92 D162 I167 G168 G207 S208 L227 G229 G230 4.2.3.3,5.3.1.1 0004807,0005737,0005829,0006006,0006094,0006096,0008929,0016829,0016853,0019242,0019563,0019682,0031625,0042803,0046166,0061621 P00940 7577950 250 RKFFVGGNWKMNGDKKSLGELIHTLNGAKLSADTEVVCGAPSIYLDFARQKLDAKIGVAAQNCYKVPKGAFTGEISPAMIKDIGAAWVILGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKAIADNVKDWSKVVLAYDPVWAIGTGKTATPQQAQEVHEKLRGWLKTHVSDAVAQSTRIIYGGSVTGGNCKELASQHDVDGFLVGGASLKPEFVDIINAKH 1tpc 1 1.9 BS01 PGH 1 1 K13 H95 D165 I170 G171 G210 S211 L230 G232 K10 H92 D162 I167 G168 G207 S208 L227 G229 4.2.3.3,5.3.1.1 0004807,0005737,0005829,0006006,0006094,0006096,0008929,0016829,0016853,0019242,0019563,0019682,0031625,0042803,0046166,0061621 P00940 7577950 250 RKFFVGGNWKMNGDKKSLGELIHTLNGAKLSADTEVVCGAPSIYLDFARQKLDAKIGVAAQNCYKVPKGAFTGEISPAMIKDIGAAWVILGHPERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKAIADNVKDWSKVVLAYDPVWAIGTGKTATPQQAQEVHEKLRGWLKTHVSDAVAQSTRIIYGGSVTGGNCKELASQHDVDGFLVGGASLKPEFVDIINAKH 1tpc 2 1.9 BS01 PGH 2 1 K13 H95 D165 I170 G171 G210 S211 L230 G232 K10 H92 D162 I167 G168 G207 S208 L227 G229 4.2.3.3,5.3.1.1 0004807,0005737,0005829,0006006,0006094,0006096,0008929,0016829,0016853,0019242,0019563,0019682,0031625,0042803,0046166,0061621 P00940 7577950 250 RKFFVGGNWKMNGDKKSLGELIHTLNGAKLSADTEVVCGAPSIYLDFARQKLDAKIGVAAQNCYKVPKGAFTGEISPAMIKDIGAAWVILGHPERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKAIADNVKDWSKVVLAYDPVWAIGTGKTATPQQAQEVHEKLRGWLKTHVSDAVAQSTRIIYGGSVTGGNCKELASQHDVDGFLVGGASLKPEFVDIINAKH 1tph 1 1.8 BS01 PGH 1 1 K13 H95 E165 I170 G171 G210 S211 L230 G232 G233 K10 H92 E162 I167 G168 G207 S208 L227 G229 G230 N11 K13 H95 E97 E165 G171 S211 N8 K10 H92 E94 E162 G168 S208 4.2.3.3,5.3.1.1 0004807,0005737,0005829,0006006,0006094,0006096,0008929,0016829,0016853,0019242,0019563,0019682,0031625,0042803,0046166,0061621 P00940 8130195 250 RKFFVGGNWKMNGDKKSLGELIHTLNGAKLSADTEVVCGAPSIYLDFARQKLDAKIGVAAQNCYKVPKGAFTGEISPAMIKDIGAAWVILGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKAIADNVKDWSKVVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKTHVSDAVAQSTRIIYGGSVTGGNCKELASQHDVDGFLVGGASLKPEFVDIINAKH 1tph 2 1.8 BS01 PGH 2 1 K13 H95 E165 I170 G171 G210 S211 L230 G232 K10 H92 E162 I167 G168 G207 S208 L227 G229 N11 K13 H95 E97 E165 G171 S211 N8 K10 H92 E94 E162 G168 S208 4.2.3.3,5.3.1.1 0004807,0005737,0005829,0006006,0006094,0006096,0008929,0016829,0016853,0019242,0019563,0019682,0031625,0042803,0046166,0061621 P00940 8130195 250 RKFFVGGNWKMNGDKKSLGELIHTLNGAKLSADTEVVCGAPSIYLDFARQKLDAKIGVAAQNCYKVPKGAFTGEISPAMIKDIGAAWVILGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKAIADNVKDWSKVVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKTHVSDAVAQSTRIIYGGSVTGGNCKELASQHDVDGFLVGGASLKPEFVDIINAKH 1tpu A 1.9 BS01 PGH A 1 K13 E165 I170 G171 G209 G210 S211 L230 G232 G233 K10 E162 I167 G168 G206 G207 S208 L227 G229 G230 N11 K13 N95 E97 E165 G171 S211 N8 K10 N92 E94 E162 G168 S208 4.2.3.3,5.3.1.1 0004807,0005737,0005829,0006006,0006094,0006096,0008929,0016829,0016853,0019242,0019563,0019682,0031625,0042803,0046166,0061621 P00940 8952501 250 RKFFVGGNWKMNGDKKSLGELIHTLNGAKLSADTEVVCGAPSIYLDFARQKLDAKIGVAAQNCYKVPKGAFTGEISPAMIKDIGAAWVILGNSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKAIADNVKDWSKVVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKTHVSDAVAQSTRIIYGGSVTGGNCKELASQHDVDGFLVGGASLKPEFVDIINAKH 1tpu B 1.9 BS01 PGH B 1 K13 E165 I170 G171 G209 S211 L230 G232 G233 K10 E162 I167 G168 G206 S208 L227 G229 G230 N11 K13 N95 E97 E165 G171 S211 N8 K10 N92 E94 E162 G168 S208 4.2.3.3,5.3.1.1 0004807,0005737,0005829,0006006,0006094,0006096,0008929,0016829,0016853,0019242,0019563,0019682,0031625,0042803,0046166,0061621 P00940 8952501 250 RKFFVGGNWKMNGDKKSLGELIHTLNGAKLSADTEVVCGAPSIYLDFARQKLDAKIGVAAQNCYKVPKGAFTGEISPAMIKDIGAAWVILGNSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKAIADNVKDWSKVVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKTHVSDAVAQSTRIIYGGSVTGGNCKELASQHDVDGFLVGGASLKPEFVDIINAKH 1tpv A 1.9 BS01 PGH A 1 N11 K13 E165 I170 G171 G210 S211 G232 G233 N8 K10 E162 I167 G168 G207 S208 G229 G230 N11 K13 N95 E97 E165 G171 S211 N8 K10 N92 E94 E162 G168 S208 4.2.3.3,5.3.1.1 0004807,0005737,0005829,0006006,0006094,0006096,0008929,0016829,0016853,0019242,0019563,0019682,0031625,0042803,0046166,0061621 P00940 8952501 250 RKFFVGGNWKMNGDKKSLGELIHTLNGAKLSADTEVVCGAPSIYLDFARQKLDAKIGVAAQNCYKVPKGAFTGEISPAMIKDIGAAWVILGNPERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKAIADNVKDWSKVVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKTHVSDAVAQSTRIIYGGSVTGGNCKELASQHDVDGFLVGGASLKPEFVDIINAKH 1tpv B 1.9 BS01 PGH B 1 N11 K13 E165 I170 G171 S211 G232 G233 N8 K10 E162 I167 G168 S208 G229 G230 N11 K13 N95 E97 E165 G171 S211 N8 K10 N92 E94 E162 G168 S208 4.2.3.3,5.3.1.1 0004807,0005737,0005829,0006006,0006094,0006096,0008929,0016829,0016853,0019242,0019563,0019682,0031625,0042803,0046166,0061621 P00940 8952501 250 RKFFVGGNWKMNGDKKSLGELIHTLNGAKLSADTEVVCGAPSIYLDFARQKLDAKIGVAAQNCYKVPKGAFTGEISPAMIKDIGAAWVILGNPERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKAIADNVKDWSKVVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKTHVSDAVAQSTRIIYGGSVTGGNCKELASQHDVDGFLVGGASLKPEFVDIINAKH 1tpw A 1.9 BS01 PGH A 1 K13 H95 E165 I170 G171 G210 S211 L230 G232 K10 H92 E162 I167 G168 G207 S208 L227 G229 N11 K13 H95 E97 E165 G171 S211 N8 K10 H92 E94 E162 G168 S208 4.2.3.3,5.3.1.1 0004807,0005737,0005829,0006006,0006094,0006096,0008929,0016829,0016853,0019242,0019563,0019682,0031625,0042803,0046166,0061621 Ki=0.5mM -logKd/Ki=3.30, Ki=0.5mM P00940 10194358 250 RKFFVGGNWKMNGDKKSLGELIHTLNGAKLSADTEVVCGAPSIYLDFARQKLDAKIGVAAQNCYKVPKGAFTGEISPAMIKDIGAAWVILGHPERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKAIADNVKDWSKVVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKTHVSDAVAQSTRIIYGGSVTGGNCKELASQHDVDGFLVGGASLKPEFVDIINAKH 1tpw B 1.9 BS01 PGH B 1 N11 K13 H95 E165 I170 G171 G210 S211 L230 G232 G233 N8 K10 H92 E162 I167 G168 G207 S208 L227 G229 G230 N11 K13 H95 E97 E165 G171 S211 N8 K10 H92 E94 E162 G168 S208 4.2.3.3,5.3.1.1 0004807,0005737,0005829,0006006,0006094,0006096,0008929,0016829,0016853,0019242,0019563,0019682,0031625,0042803,0046166,0061621 Ki=0.5mM -logKd/Ki=3.30, Ki=0.5mM P00940 10194358 250 RKFFVGGNWKMNGDKKSLGELIHTLNGAKLSADTEVVCGAPSIYLDFARQKLDAKIGVAAQNCYKVPKGAFTGEISPAMIKDIGAAWVILGHPERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKAIADNVKDWSKVVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKTHVSDAVAQSTRIIYGGSVTGGNCKELASQHDVDGFLVGGASLKPEFVDIINAKH 1trd B 2.5 BS01 PGH B 1 H95 E167 S213 L232 G234 H94 E166 S212 L231 G233 N11 K13 H95 E97 E167 G173 S213 N10 K12 H94 E96 E166 G172 S212 5.3.1.1 0004807,0005737,0005829,0006094,0006096,0016853,0019563,0020015,0046166 Ki=4uM -logKd/Ki=5.40, Ki=4uM P04789 8356028 300 SKPQPIAAANWKCNGSQQSLSELIDLFNSTSINHDVQCVVASTFVHLAMTKERLSHPKFVIAAQNAIAKSGAFTGEVSLPILKDFGVNWIVLGHSERRAYYGETNEIVADKVAAAVASGFMVIACIGETLQERESGRTAVVVLTQIAAIAKKLKKADWAKVVIAYEPVWAIGTGKVATPQQAQEAHALIRSWVSSKIGADVAGELRILYGGSVNGKNARTLYQQRDVNGFLVGGASLKPEFVDIIKATQ 1ttj A 2.4 BS01 PGH A 1 N11 H95 E167 I172 G173 G212 S213 G234 N10 H80 E152 I157 G158 G197 S198 G219 N11 H95 E97 E167 G173 S213 N10 H80 E82 E152 G158 S198 5.3.1.1 0004807,0005737,0005829,0006094,0006096,0016853,0019563,0020015,0046166 P04789 8591044 600 SKPQPIAAANWSLSELIDLFNSTSINHDVQCVVASTSSHLAMTKERLSHPKFVIAAQNAGNADALASLKDFGVNWIVLGHSERRAYYGETNEIVADKVAAAVASGFMVIACIGETLQERESGRTAVVVLTQIAAIAKKLKKADWAKVVIAYEPVWAIGTGKVATPQQAQEAHALIRSWVSSKIGADVAGELRILYGGSVNGKNARTLYQQRDVNGFLVGGASLKPEFVDIIKATQ 2isv A 2.3 BS02 PGH A 1 D83 H178 H210 G211 S213 N253 D255 S256 D82 H163 H186 G187 S189 N229 D231 S232 4.1.2.13 0004332,0005515,0005975,0006096,0008270,0016829,0016832,0046872 Ki=37nM -logKd/Ki=7.43, Ki=37nM A8B2U2 17166851 325 PLCTLRQMLGEARKHKYGVGAFNVNNMEQIQGIMKAVVQLKSPVILQCSRGALKYSDMIYLKKLCEAALEKHPDIPICIHLDHGDTLESVKMAIDLGFSSVMIDASHHPFDENVRITKEVVAYAHARSVSVEAELGLTEPQDAKKFVELTGVDALAVAIGTSHGARLAIDRVKTISDLTGIPLVMHGSSSVPKDVKDMINKYGGKMPDAVGVPIESIVHAIGEGVCKINVDSDSRMAMTGAIRKVFVEHPEKFDPRDYLGPGRDAITEMLIPKIKAFGSAGHAGDYKVVSLEEAKAWY 2isv B 2.3 BS02 PGH B 1 D83 H178 G179 K182 H210 G211 S213 N253 D255 S256 D82 H168 G169 K172 H195 G196 S198 N238 D240 S241 4.1.2.13 0004332,0005515,0005975,0006096,0008270,0016829,0016832,0046872 Ki=37nM -logKd/Ki=7.43, Ki=37nM A8B2U2 17166851 325 PLCTLRQMLGEARKHKYGVGAFNVNNMEQIQGIMKAVVQLKSPVILQCSRGALKYSDMIYLKKLCEAALEKHPDIPICIHLDHGDTLESVKMAIDLGFSSVMIDASHHPFDENVRITKEVVAYAHARSVSVEAELGQNTVQLTEPQDAKKFVELTGVDALAVAIGTSHGAYKFIRLAIDRVKTISDLTGIPLVMHGSSSVPKDVKDMINKYGGKMPDAVGVPIESIVHAIGEGVCKINVDSDSRMAMTGAIRKVFVEHPEKFDPRDYLGPGRDAITEMLIPKIKAFGSAGHAGDYKVVSLEEAKAWY 2isw A 1.75 BS02 PGH A 1 D83 H178 G179 K182 H210 G211 S213 N253 D255 S256 D82 H167 G168 K171 H195 G196 S198 N238 D240 S241 4.1.2.13 0004332,0005515,0005975,0006096,0008270,0016829,0016832,0046872 Ki=37nM -logKd/Ki=7.43, Ki=37nM A8B2U2 17166851 325 PLCTLRQMLGEARKHKYGVGAFNVNNMEQIQGIMKAVVQLKSPVILQCSRGALKYSDMIYLKKLCEAALEKHPDIPICIHLDHGDTLESVKMAIDLGFSSVMIDASHHPFDENVRITKEVVAYAHARSVSVEAELGTLVQLTEPQDAKKFVELTGVDALAVAIGTSHGAYKFKSRLAIDRVKTISDLTGIPLVMHGSSSVPKDVKDMINKYGGKMPDAVGVPIESIVHAIGEGVCKINVDSDSRMAMTGAIRKVFVEHPEKFDPRDYLGPGRDAITEMLIPKIKAFGSAGHAGDYKVVSLEEAKAWY 2vxn A 0.82 BS01 PGH A 1 K13 H95 E167 I172 G173 G212 S213 L232 G234 G235 K12 H94 E166 I171 G172 G211 S212 L231 G233 G234 N11 K13 H95 E97 E167 G173 S213 N10 K12 H94 E96 E166 G172 S212 5.3.1.1 0004807,0005737,0005829,0006094,0006096,0016853,0019563,0020015,0046166 -logKd/Ki=5.00, Kd=10uM P48499 20235230 1251 AKPQPIAAANWKCNGTTASIEKLVQVFNEHTISHDVQCVVAPTFVHIPLVQAKLRNPKYVISAQNAIAKSGAFTGEVSMPILKDIGVHWVILGHSERRTYYGETDEIVAQKVSEACKQGFMVIACIGETLQQREANQTAKVVLSQTSAIAAKLTKDAWNQVVLAYEPVWAIGTGKVATPEQAQEVHLLLRKWVSENIGTDVAAKLRILYGGSVNAANAATLYAKPDINGFLVGGASLKPEFRDIIDATR 3c52 A 2.3 BS03 PGH A 1 D82 H83 H180 K184 H210 G211 S213 N253 D255 T256 D82 H83 H169 K173 H199 G200 S202 N242 D244 T245 C69 E70 G136 H180 A226 N253 C69 E70 G136 H169 A215 N242 4.1.2.13 0004332,0005975,0006096,0008270,0016829,0016832,0030388,0046872 -logKd/Ki=7.30, Ki=0.05uM P56109 18688832 404 MLVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCERYPHIPVALHLDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIVLVNPKEAEQFVKESQVDYLAPAIGTSHGAFKFKGEPKLDFERLQEVKRLTNIPLVLHGASAIPDNVRKSYLDAGGDLKGSKGVPFEFLQESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANKI 3c52 B 2.3 BS03 PGH B 1 D82 H83 H180 K184 H210 G211 S213 N253 D255 T256 D82 H83 H168 K172 H198 G199 S201 N241 D243 T244 C69 E70 G136 H180 A226 N253 C69 E70 G136 H168 A214 N241 4.1.2.13 0004332,0005975,0006096,0008270,0016829,0016832,0030388,0046872 -logKd/Ki=7.30, Ki=0.05uM P56109 18688832 404 MLVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCERYPHIPVALHLDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGILVNPKEAEQFVKESQVDYLAPAIGTSHGAFKFKGEPKLDFERLQEVKRLTNIPLVLHGASAIPDNVRKSYLDAGGDLKGSKGVPFEFLQESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANKI 3tao A 1.45 BS01 PGH A 1 K12 H100 I177 G178 G217 S218 L237 G239 G240 K11 H99 I176 G177 G216 S217 L236 G238 G239 N10 K12 H100 E102 E172 G178 S218 N9 K11 H99 E101 E171 G177 S217 5.3.1.1 0004807,0005515,0005576,0005737,0005829,0005886,0006094,0006096,0016853,0019563,0046166 Kd=7.28uM -logKd/Ki=5.14, Kd=7.28uM P9WG43 22120738 268 SRKPLIAGNWKMNLNHYEAIALVQKIAFSLPDKYYDRVDVAVIPPFTDLRSVQTLVDGDKLRLTYGAQDLSPHDSGAYTGDVSGAFLAKLGCSYVVVGHSERRTYHNEDDALVAAKAATALKHGLTPIVCIGEHLDVREAGNHVAHNIEQLRGSLAGLLAEQIGSVVIAYEPVWAIGTGRVASAADAQEVCAAIRKELASLASPRIADTVRVLYGGSVNAKNVGDIVAQDDVDGGLVGGASLDGEHFATLAAIAAG 3tao A 1.45 BS02 PGH A 2 R51 S52 T55 R50 S51 T54 N10 K12 H100 E102 E172 G178 S218 N9 K11 H99 E101 E171 G177 S217 5.3.1.1 0004807,0005515,0005576,0005737,0005829,0005886,0006094,0006096,0016853,0019563,0046166 Kd=7.28uM -logKd/Ki=5.14, Kd=7.28uM P9WG43 22120738 269 SRKPLIAGNWKMNLNHYEAIALVQKIAFSLPDKYYDRVDVAVIPPFTDLRSVQTLVDGDKLRLTYGAQDLSPHDSGAYTGDVSGAFLAKLGCSYVVVGHSERRTYHNEDDALVAAKAATALKHGLTPIVCIGEHLDVREAGNHVAHNIEQLRGSLAGLLAEQIGSVVIAYEPVWAIGTGRVASAADAQEVCAAIRKELASLASPRIADTVRVLYGGSVNAKNVGDIVAQDDVDGGLVGGASLDGEHFATLAAIAAG 3ypi A 2.8 BS01 PGH A 1 K12 E165 I170 G171 S211 G232 G233 K11 E164 I169 G170 S210 G231 G232 N10 K12 Q95 E97 E165 G171 S211 N9 K11 Q94 E96 E164 G170 S210 5.3.1.1 0004807,0005737,0005739,0005829,0005886,0006094,0006096,0016853,0019563,0046166 P00942 2007138 249 ARTFFVGGNFKLNGSKQSIKEIVERLNTASIPENVEVVICPPATYLDYSVSLVKKPQVTVGAQNAYLKASGAFTGENSVDQIKDVGAKWVILGQSERRSYFHEDDKFIADKTKFALGQGVGVILCIGETLEEKKAGKTLDVVERQLNAVLEEVKDWTNVVVAYEPVWAIGTGLAATPEDAQDIHASIRKFLASKLGDKAASELRILYGGSANGSNAVTFKDKADVDGFLVGGASLKPEFVDIINSRN 3ypi B 2.8 BS01 PGH B 1 E165 I170 G171 G210 S211 L230 G232 E164 I169 G170 G209 S210 L229 G231 N10 K12 Q95 E97 E165 G171 S211 N9 K11 Q94 E96 E164 G170 S210 5.3.1.1 0004807,0005737,0005739,0005829,0005886,0006094,0006096,0016853,0019563,0046166 P00942 2007138 249 ARTFFVGGNFKLNGSKQSIKEIVERLNTASIPENVEVVICPPATYLDYSVSLVKKPQVTVGAQNAYLKASGAFTGENSVDQIKDVGAKWVILGQSERRSYFHEDDKFIADKTKFALGQGVGVILCIGETLEEKKAGKTLDVVERQLNAVLEEVKDWTNVVVAYEPVWAIGTGLAATPEDAQDIHASIRKFLASKLGDKAASELRILYGGSANGSNAVTFKDKADVDGFLVGGASLKPEFVDIINSRN 4del A 1.58 BS03 PGH A 1 D95 H96 H212 G213 H252 G253 S255 N274 D276 T277 D94 H95 H211 G212 H251 G252 S254 N273 D275 T276 D95 H96 E169 H212 H252 N274 D94 H95 E168 H211 H251 N273 4.1.2.13 0004332,0005576,0005829,0005886,0005975,0006096,0008270,0009274,0016829,0016832,0035375,0046872 Kd=21.1nM -logKd/Ki=7.68, Kd=21.1nM P9WQA3 23298222 404 PIATPEVYAEMLGQAKQNSYAFPAINCTSSETVNAAIKGFADAGSDGIIQFSTGGAEFGSGLGVKDMVTGAVALAEFTHVIAAKYPVNVALHTDHCPKDKLDSYVRPLLAISAQRVSKGGNPLFQSHMWDGSAVPIDENLAIAQELLKAAAAAKIILEIEIGVVGGEEDGVANEINEKLYTSPEDFEKTIEALGAGEHGKYLLAATFGNVHGVYKPGNVKLRPDILAQGQQVAAAKLGLPADAKPFDFVFHGGSGSLKSEIEEALRYGVVKMNVDTDTQYAFTRPIAGHMFTNYDGVLKVDGEVGVKKVYDPRSYLKKAEASMSQRVVQACNDLHCAGKSLTHHH 4fua A 2.43 BS02 PGH A 1 G28 N29 T43 S71 S72 E73 H92 H94 H155 G28 N29 T43 S71 S72 E73 H92 H94 H155 E73 H92 H94 Y113 A117 H155 E73 H92 H94 Y113 A117 H155 4.1.2.17 0005829,0005996,0006004,0008270,0008738,0016829,0016830,0016832,0019317,0019323,0019568,0019571,0042355,0046872 Ki=4uM P0AB87 8676381 217 MERNKLARQIIDTCLEMTRLGLNQGTAGNVSVRYQDGMLITPTGIPYEKLTESHIVFIDGNGKHEEGKLPSSEWRFHMAAYQSRPDANAVVHNHAVHCTAVSILNRSIPAIHYMIAAAGGNSIPCAPYATFGTRELSEHVALALKNRKATLLQHHGLIACEVNLEKALWLAHEVEVLAQLYLTTLAITDPVPVLSDEEIAVVLEKF 5f33 A 1.45 BS02 PGH A 1 H19 Y21 D35 S36 H193 E195 S209 T210 H24 Y26 D40 S41 H198 E200 S214 T215 2.5.1.72 0005737,0005829,0008987,0009435,0016740,0016765,0019363,0019805,0034628,0046872,0051539 Q9X1X7 27545412 302 HHHHHMVDEILKLKKEKGYIILAHNYQIPELQDIADFVGDSLQLARKAMELSEKKILFLGVDFMAELVKILNPDKKVIVPDRSATCPMANRLTPEIIREYREKFPDAPVVLFVNSTSECKTLADVICTSANAVEVVKKLDSSVVIFGPDRNLGEYVAEKTGKKVITIPENGHCPVHQFNAESIDAVRKKYPDAKVIVHPECPKPVRDKADYVGSTGQMEKIPERDPSRIFVIGTEIGMIHKLKKKFPDREFVPLEMAVCVNMKKNTLENTLHALQTESFEVILPKEVIEKAKKPILRMFELMG 6f4d A 2.0 BS02 PGH A 1 H19 F21 D35 S36 H171 H193 E195 S209 T210 H25 F27 D41 S42 H177 H199 E201 S215 T216 2.5.1.72 0005737,0005829,0008987,0009435,0016740,0016765,0019363,0019805,0034628,0046872,0051539 Q9X1X7 29641168 302 HHHHHHMVDEILKLKKEKGYIILAHNFQIPELQDIADFVGDSLQLARKAMELSEKKILFLGVDFMAELVKILNPDKKVIVPDRSATCPMANRLTPEIIREYREKFPDAPVVLYVNSTSECKTLADVICTSANAVEVVKKLDSSVVIFGPDRNLGEYVAEKTGKKVITIPENGHCPVHQFNAESIDAVRKKYPDAKVIVHPECPKPVRDKADYVGSTGQMEKIPERDPSRIFVIGTEIGMIHKLKKKFPDREFVPLEMAVCVNMKKNTLENTLHALQTESFEVILPKEVIEKAKKPILRMFELMG 6nee A 1.9 BS01 PGH A 1 K12 H96 E167 I172 G173 G212 S213 L232 G234 G235 K11 H95 E166 I171 G172 G211 S212 L231 G233 G234 0004807,0006096 30589511 301 SRKFFVGGNWKMNGTLESIKALVETLNSAQLDPNTEVVVAPPAIYLPFARSKLKKPKEIQVAAQNCYTKPNGAFTGEISAEMLKDLGVPWVILGHSERRTIFGESDELIAEKVKYALDQGLKVIACIGETLEEREAGKTMEVVARQILKAIADKIKDWSNVVIAYEPVWAIGTGKVATPEQAQEVHAALRKWLKENVSPEVAESTRIIYGGSVNAANCKELAKQPDIDGFLVGGASLKAPEFVDIINARQ 6nee B 1.9 BS01 PGH B 1 K12 H96 E167 I172 G212 S213 L232 G234 G235 K13 H97 E168 I173 G213 S214 L233 G235 G236 0004807,0006096 30589511 301 MASRKFFVGGNWKMNGTLESIKALVETLNSAQLDPNTEVVVAPPAIYLPFARSKLKKPKEIQVAAQNCYTKPNGAFTGEISAEMLKDLGVPWVILGHSERRTIFGESDELIAEKVKYALDQGLKVIACIGETLEEREAGKTMEVVARQILKAIADKIKDWSNVVIAYEPVWAIGTGKVATPEQAQEVHAALRKWLKENVSPEVAESTRIIYGGSVNAANCKELAKQPDIDGFLVGGASLKAPEFVDIINARQ 7az9 A 1.1 BS01 PGH A 1 K13 H95 E167 I172 G173 G212 S213 L232 G234 G235 K12 H94 E166 I171 G172 G211 S212 L231 G233 G234 5.3.1.1 0004807,0005737,0005829,0006094,0006096,0016853,0019563,0020015,0046166 P48499 34258011 301 AKPQPIAAANWKCNGTTASIEKLVQVFNEHTISHDVQCVVAPTFVHIPLVQAKLRNPKYVISAQNAIAKSGAFTGEVSMPILKDIGVHWVILGHSERRTYYGETDEIVAQKVSEACKQGFMVIACIGETLQQREANQTAKVVLSQTSAIAAKLTKDAWNQVVLAYEPVWAIGTGKVATPEQAQEVHLLLRKWVSENIGTDVAAKLRILYGGSVNAANAATLYAKPDINGFLVGGASLKPEFRDIIDATR 7aza A 1.1 BS01 PGH A 1 N11 K13 H95 E167 I172 G173 G212 S213 L232 G234 G235 N10 K12 H94 E166 I171 G172 G211 S212 L231 G233 G234 5.3.1.1 0004807,0005737,0005829,0006094,0006096,0016853,0019563,0020015,0046166 P48499 34258011 301 AKPQPIAAANWKCNGTTASIEKLVQVFNEHTISHDVQCVVAPTFVHIPLVQAKLRNPKYVISAQNAIAKSGAFTGEVSMPILKDIGVHWVILGHSERRTYYGETDEIVAQKVSEACKQGFMVIACIGETLQQREANQTAKVVLSQTSAIAAKLTKDAWNQVVLAYEPVWAIGTGKVATPEQAQEVHLLLRKWVSENIGTDVAAKLRILYGGSVNAANAATLYAKPDINGFLVGGASLKPEFRDIIDATR 7tim A 1.9 BS01 PGH A 1 K12 H95 E165 I170 G171 S211 L230 G232 G233 K11 H94 E164 I169 G170 S210 L229 G231 G232 N10 K12 H95 E97 E165 G171 S211 N9 K11 H94 E96 E164 G170 S210 5.3.1.1 0004807,0005737,0005739,0005829,0005886,0006094,0006096,0016853,0019563,0046166 P00942 2043623 249 ARTFFVGGNFKLNGSKQSIKEIVERLNTASIPENVEVVICPPATYLDYSVSLVKKPQVTVGAQNAYLKASGAFTGENSVDQIKDVGAKWVILGHSERRSYFHEDDKFIADKTKFALGQGVGVILCIGETLEEKKAGKTLDVVERQLNAVLEEVKDWTNVVVAYEPVWAIGTGLAATPEDAQDIHASIRKFLASKLGDKAASELRILYGGSANGSNAVTFKDKADVDGFLVGGASLKPEFVDIINSRN 7tim B 1.9 BS01 PGH B 1 K12 H95 E165 I170 G171 S211 L230 G232 G233 K11 H94 E164 I169 G170 S210 L229 G231 G232 N10 K12 H95 E97 E165 G171 S211 N9 K11 H94 E96 E164 G170 S210 5.3.1.1 0004807,0005737,0005739,0005829,0005886,0006094,0006096,0016853,0019563,0046166 P00942 2043623 249 ARTFFVGGNFKLNGSKQSIKEIVERLNTASIPENVEVVICPPATYLDYSVSLVKKPQVTVGAQNAYLKASGAFTGENSVDQIKDVGAKWVILGHSERRSYFHEDDKFIADKTKFALGQGVGVILCIGETLEEKKAGKTLDVVERQLNAVLEEVKDWTNVVVAYEPVWAIGTGLAATPEDAQDIHASIRKFLASKLGDKAASELRILYGGSANGSNAVTFKDKADVDGFLVGGASLKPEFVDIINSRN 8v09 A 1.61 BS01 PGH A 1 K12 H94 E166 I171 G211 S212 L231 G233 G234 K11 H93 E165 I170 G210 S211 L230 G232 G233 39145435 307 ARKFFVGGNWKMNGSKASIKSLVETLNASKLDNKTEVVVAPPAIYLPQVRQALRKDIQVAAQNCYTKASGAFTGEISPEMLKDLGIPWVILGHSERRHIFGESDEFVAEKVKYALDQGLKVIACIGETLEEREAGKTMEVCARQLKAIAKKISESDWSNVVIAYEPVWAIGTGKVATPEQAQEVHAAIRKWLAENVSAEVAESTRIIYGGSVNGGNCAELAKQPDIDGFLVGGASLKPEFVDIINARK 8v0a B 2.05 BS01 PGH B 1 N10 K12 H94 S212 L231 G233 N9 K11 H93 S211 L230 G232 39145435 301 ARKFFVGGNWKMNGSVESIKSLVETLNNAELDPNVEVVIAPPAVYLPLVREALRKDIQVAAQNCYTKASGAYTGEISAEMLKDLGIPWVILGHSERRHIFGESDELVAEKTKYALDSGLSVILCIGETLEEREAGKTMDVVARQLKAIADKITENDWSKVVIAYEPVWAIGTGKVATPEQAQEVHAEIRKWLAENVSAEVAESTRIIYGGSVNGGNCKELAKQPDIDGFLVGGASLKPEFVDIINAKQA 8w06 A 2.06 BS01 PGH A 1 N10 K12 H94 E166 I171 G172 G211 S212 L231 G233 G234 N11 K13 H95 E167 I172 G173 G212 S213 L232 G234 G235 39145435 301 HMARKFFVGGNWKMNGTIESIKSLVETLNNAELDDNTEVVVAPPAIYLPLVRQSLRKDIQVAAQNCYTKASGAFTGEISAEMLKDLGIPWVILGHSERRQIFGESDEFVAEKTKYALDNGLKVILCIGETLEEREAGKTMDVVTRQLKAIADKISESDWSKVVIAYEPVWAIGTGKVATPEQAQEVHAEIRKWLAENVSAEVAESTRIIYGGSVNGGNCKELAKQPDIDGFLVGGASLKPEFVDIINARQ 8w06 B 2.06 BS01 PGH B 1 K12 H94 E166 I171 G172 S212 L231 G233 G234 K13 H95 E167 I172 G173 S213 L232 G234 G235 39145435 301 HMARKFFVGGNWKMNGTIESIKSLVETLNNAELDDNTEVVVAPPAIYLPLVRQSLRKDIQVAAQNCYTKASGAFTGEISAEMLKDLGIPWVILGHSERRQIFGESDEFVAEKTKYALDNGLKVILCIGETLEEREAGKTMDVVTRQLKAIADKISESDWSKVVIAYEPVWAIGTGKVATPEQAQEVHAEIRKWLAENVSAEVAESTRIIYGGSVNGGNCKELAKQPDIDGFLVGGASLKPEFVDIINARQK 8w06 C 2.06 BS01 PGH C 1 K12 H94 E166 I171 G172 G211 S212 L231 G233 G234 K12 H94 E166 I171 G172 G211 S212 L231 G233 G234 39145435 301 MARKFFVGGNWKMNGTIESIKSLVETLNNAELDDNTEVVVAPPAIYLPLVRQSLRKDIQVAAQNCYTKASGAFTGEISAEMLKDLGIPWVILGHSERRQIFGESDEFVAEKTKYALDNGLKVILCIGETLEEREAGKTMDVVTRQLKAIADKISESDWSKVVIAYEPVWAIGTGKVATPEQAQEVHAEIRKWLAENVSAEVAESTRIIYGGSVNGGNCKELAKQPDIDGFLVGGASLKPEFVDIINARQK 8w06 D 2.06 BS01 PGH D 1 N10 K12 H94 E166 I171 G172 G211 S212 L231 G233 G234 N12 K14 H96 E168 I173 G174 G213 S214 L233 G235 G236 39145435 302 SHMARKFFVGGNWKMNGTIESIKSLVETLNNAELDDNTEVVVAPPAIYLPLVRQSLRKDIQVAAQNCYTKASGAFTGEISAEMLKDLGIPWVILGHSERRQIFGESDEFVAEKTKYALDNGLKVILCIGETLEEREAGKTMDVVTRQLKAIADKISESDWSKVVIAYEPVWAIGTGKVATPEQAQEVHAEIRKWLAENVSAEVAESTRIIYGGSVNGGNCKELAKQPDIDGFLVGGASLKPEFVDIINARQ 8w06 E 2.06 BS01 PGH E 1 K12 H94 E166 I171 S212 L231 G233 G234 K14 H96 E168 I173 S214 L233 G235 G236 39145435 301 SHMARKFFVGGNWKMNGTIESIKSLVETLNNAELDDNTEVVVAPPAIYLPLVRQSLRKDIQVAAQNCYTKASGAFTGEISAEMLKDLGIPWVILGHSERRQIFGESDEFVAEKTKYALDNGLKVILCIGETLEEREAGKTMDVVTRQLKAIADKISESDWSKVVIAYEPVWAIGTGKVATPEQAQEVHAEIRKWLAENVSAEVAESTRIIYGGSVNGGNCKELAKQPDIDGFLVGGASLKPEFVDIINARQ 8w06 F 2.06 BS01 PGH F 1 N10 K12 H94 E166 I171 G172 G211 S212 L231 G233 G234 N12 K14 H96 E168 I173 G174 G213 S214 L233 G235 G236 39145435 302 SHMARKFFVGGNWKMNGTIESIKSLVETLNNAELDDNTEVVVAPPAIYLPLVRQSLRKDIQVAAQNCYTKASGAFTGEISAEMLKDLGIPWVILGHSERRQIFGESDEFVAEKTKYALDNGLKVILCIGETLEEREAGKTMDVVTRQLKAIADKISESDWSKVVIAYEPVWAIGTGKVATPEQAQEVHAEIRKWLAENVSAEVAESTRIIYGGSVNGGNCKELAKQPDIDGFLVGGASLKPEFVDIINARQ 8w06 G 2.06 BS01 PGH G 1 K12 H94 E166 I171 G211 S212 L231 G233 G234 K11 H93 E165 I170 G210 S211 L230 G232 G233 39145435 301 ARKFFVGGNWKMNGTIESIKSLVETLNNAELDDNTEVVVAPPAIYLPLVRQSLRKDIQVAAQNCYTKASGAFTGEISAEMLKDLGIPWVILGHSERRQIFGESDEFVAEKTKYALDNGLKVILCIGETLEEREAGKTMDVVTRQLKAIADKISESDWSKVVIAYEPVWAIGTGKVATPEQAQEVHAEIRKWLAENVSAEVAESTRIIYGGSVNGGNCKELAKQPDIDGFLVGGASLKPEFVDIINARQK 8w06 H 2.06 BS01 PGH H 1 K12 H94 E166 I171 G172 G211 S212 L231 G233 K10 H92 E164 I169 G170 G209 S210 L229 G231 39145435 301 RKFFVGGNWKMNGTIESIKSLVETLNNAELDDNTEVVVAPPAIYLPLVRQSLRKDIQVAAQNCYTKASGAFTGEISAEMLKDLGIPWVILGHSERRQIFGESDEFVAEKTKYALDNGLKVILCIGETLEEREAGKTMDVVTRQLKAIADKISESDWSKVVIAYEPVWAIGTGKVATPEQAQEVHAEIRKWLAENVSAEVAESTRIIYGGSVNGGNCKELAKQPDIDGFLVGGASLKPEFVDIINAR