1arz B 2.6 BS02 PDC B 1 T104 H160 K163 S168 G169 T170 F243 T100 H156 K159 S164 G165 T166 F239 H159 K163 H155 K159 1.17.1.8 0005737,0005829,0008652,0008839,0009085,0009089,0016491,0016726,0019877,0042802,0050661,0051287 P04036 9398235 303 NIRVAIAGAGGRMGRQLIQAALALEGVQLGAALEREGSSLLGSDAGELAGAGKTGVTVQSSLDAVKDDFDVFIDFTRPEGTLNHLAFCRQHGKGMVIGTTGFDEAGKQAIRDAAADIAIVFAANFSVGVNVMLKLLEKAAKVMGDYTDIEIIEAHHRHKVDAPSGTALAMGEAIAHALDKDLKDCAVYSREGHTGERVPGTIGFATVRAGDIVGEHTAMFADIGERLEITHKASSRMTFANGAVRSALWLSGKESGLFDMRDVLDLNNL 1arz C 2.6 BS02 PDC C 1 T104 K163 S168 G169 T170 T102 K161 S166 G167 T168 H159 K163 H157 K161 1.17.1.8 0005737,0005829,0008652,0008839,0009085,0009089,0016491,0016726,0019877,0042802,0050661,0051287 P04036 9398235 302 DANIRVAIAGAGGRMGRQLIQAALALEGVQLGAALEREGSSLLGSDAGELAGAGKTGVTVQSSLDAVKDDFDVFIDFTRPEGTLNHLAFCRQHGKGMVIGTTGFDEAGKQAIRDAAADIAIVFAANFSVGVNVMLKLLEKAAKVMGDYTDIEIIEAHHRHKVDAPSGTALAMGEAIAHALDKDLKDCAVYSREGHTGERVPGTIGFATVRAGDIVGEHTAMFADIGERLEITHKASSRMTFANGAVRSALWLSGKESGLFDMRDVLDLNNL 1arz D 2.6 BS02 PDC D 1 T104 A127 K163 S168 G169 T170 T102 A125 K161 S166 G167 T168 H159 K163 H157 K161 1.17.1.8 0005737,0005829,0008652,0008839,0009085,0009089,0016491,0016726,0019877,0042802,0050661,0051287 P04036 9398235 303 DANIRVAIAGAGGRMGRQLIQAALALEGVQLGAALEREGSSLLGSDAGELAGAGKTGVTVQSSLDAVKDDFDVFIDFTRPEGTLNHLAFCRQHGKGMVIGTTGFDEAGKQAIRDAAADIAIVFAANFSVGVNVMLKLLEKAAKVMGDYTDIEIIEAHHRHKVDAPSGTALAMGEAIAHALDKDLKDCAVYSREGHTGERVPGTIGFATVRAGDIVGEHTAMFADIGERLEITHKASSRMTFANGAVRSALWLSGKESGLFDMRDVLDLNNL 1c3v A 2.39 BS02 PDC A 1 T577 N604 K636 S641 G642 T643 A692 T77 N104 K136 S141 G142 T143 A192 H632 K636 H132 K136 1.17.1.8 0005737,0005829,0005886,0008839,0009085,0009089,0009274,0016491,0016726,0019877,0050661,0051287,0070402,0070404 P9WP23 12962488 802 MRVGVLGAKGKVGTTMVRAVAAADDLTLSAELDAGDPLSLLTDGNTEVVIDFTHPDVVMGNLEFLIDNGIHAVVGTTGFTAERFQQVESWLVAKPNTSVLIAPNFAIGAVLSMHFAKQAARFFDSAEVIELHHPHKADAPSGTAARTAKLIAEARKGLPPNPDATSTSLPGARGADVDGIPVHAVRLAGLVAHQEVLFGTEGETLTIRHDSLDRTSFVPGVLLAVRRIAERPGLTVGLEPLLDLH 1c3v B 2.39 BS02 PDC B 1 T1077 N1104 K1136 S1141 G1142 T1143 A1192 T77 N104 K136 S141 G142 T143 A192 H1132 K1136 H132 K136 1.17.1.8 0005737,0005829,0005886,0008839,0009085,0009089,0009274,0016491,0016726,0019877,0050661,0051287,0070402,0070404 P9WP23 12962488 1302 MRVGVLGAKGKVGTTMVRAVAAADDLTLSAELDAGDPLSLLTDGNTEVVIDFTHPDVVMGNLEFLIDNGIHAVVGTTGFTAERFQQVESWLVAKPNTSVLIAPNFAIGAVLSMHFAKQAARFFDSAEVIELHHPHKADAPSGTAARTAKLIAEARKGLPPNPDATSTSLPGARGADVDGIPVHAVRLAGLVAHQEVLFGTEGETLTIRHDSLDRTSFVPGVLLAVRRIAERPGLTVGLEPLLDLH 1p9l A 2.3 BS02 PDC A 1 H133 K136 S141 G142 T143 A192 H133 K136 S141 G142 T143 A192 H132 K136 H132 K136 1.17.1.8 0005737,0005829,0005886,0008839,0009085,0009089,0009274,0016491,0016726,0019877,0050661,0051287,0070402,0070404 P9WP23 12962488 302 MRVGVLGAKGKVGTTMVRAVAAADDLTLSAELDAGDPLSLLTDGNTEVVIDFTHPDVVMGNLEFLIDNGIHAVVGTTGFTAERFQQVESWLVAKPNTSVLIAPNFAIGAVLSMHFAKQAARFFDSAEVIELHHPHKADAPSGTAARTAKLIAEARKGLPPNPDATSTSLPGARGADVDGIPVHAVRLAGLVAHQEVLFGTEGETLTIRHDSLDRTSFVPGVLLAVRRIAERPGLTVGLEPLLDLH 1p9l B 2.3 BS02 PDC B 1 T77 K136 S141 G142 T143 T77 K136 S141 G142 T143 H132 K136 H132 K136 1.17.1.8 0005737,0005829,0005886,0008839,0009085,0009089,0009274,0016491,0016726,0019877,0050661,0051287,0070402,0070404 P9WP23 12962488 402 MRVGVLGAKGKVGTTMVRAVAAADDLTLSAELDAGDPLSLLTDGNTEVVIDFTHPDVVMGNLEFLIDNGIHAVVGTTGFTAERFQQVESWLVAKPNTSVLIAPNFAIGAVLSMHFAKQAARFFDSAEVIELHHPHKADAPSGTAARTAKLIAEARKGLPPNPDATSTSLPGARGADVDGIPVHAVRLAGLVAHQEVLFGTEGETLTIRHDSLDRTSFVPGVLLAVRRIAERPGLTVGLEPLLDLH 2pc2 A 1.538 BS01 PDC A 1 C6 C127 R128 C6 C127 R128 E35 N46 D48 S50 D52 N59 E35 N46 D48 S50 D52 N59 3.2.1.17 0003796,0005515,0005576,0005615,0005737,0005783,0016231,0016798,0016998,0031640,0042742,0042802,0050829,0050830,0051672 P00698 18350532 302 KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL 2pc2 A 1.538 BS02 PDC A 2 G4 R5 C6 E7 G4 R5 C6 E7 E35 N46 D48 S50 D52 N59 E35 N46 D48 S50 D52 N59 3.2.1.17 0003796,0005515,0005576,0005615,0005737,0005783,0016231,0016798,0016998,0031640,0042742,0042802,0050829,0050830,0051672 P00698 18350532 303 KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL 2pc2 A 1.538 BS03 PDC A 3 R125 G126 R125 G126 E35 N46 D48 S50 D52 N59 E35 N46 D48 S50 D52 N59 3.2.1.17 0003796,0005515,0005576,0005615,0005737,0005783,0016231,0016798,0016998,0031640,0042742,0042802,0050829,0050830,0051672 P00698 18350532 402 KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL 2pc2 A 1.538 BS04 PDC A 4 R125 G126 R125 G126 E35 N46 D48 S50 D52 N59 E35 N46 D48 S50 D52 N59 3.2.1.17 0003796,0005515,0005576,0005615,0005737,0005783,0016231,0016798,0016998,0031640,0042742,0042802,0050829,0050830,0051672 P00698 18350532 403 KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL 2pc2 A 1.538 BS05 PDC A 5 R61 W62 R61 W62 E35 N46 D48 S50 D52 N59 E35 N46 D48 S50 D52 N59 3.2.1.17 0003796,0005515,0005576,0005615,0005737,0005783,0016231,0016798,0016998,0031640,0042742,0042802,0050829,0050830,0051672 P00698 18350532 502 KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL 2pc2 A 1.538 BS06 PDC A 6 R21 G22 Y23 R21 G22 Y23 E35 N46 D48 S50 D52 N59 E35 N46 D48 S50 D52 N59 3.2.1.17 0003796,0005515,0005576,0005615,0005737,0005783,0016231,0016798,0016998,0031640,0042742,0042802,0050829,0050830,0051672 P00698 18350532 702 KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL 2pe7 A 1.46 BS01 PDC A 1 R82 P83 R82 P83 ? 0005576,0006952,0031410 P02883 20606256 602 ATFEIVNRCSYTVWAAASKGDAALDAGGRQLNSGESWTINVEPGTNGGKIWARTDCYFDDSGSGICKTGDCGGLLRCKRFGRPPTTLAEFSLNQYGKDYIDISNIKGFNVPMDFSPTTRGCRGVRCAADIVGQCPAKLKAPGGGCNDACTVFQTSEYCCTTGKCGPTEYSRFFKRLCPDAFSYVLDKPTTVTCPGSSNYRVTFCPTA 2pe7 A 1.46 BS02 PDC A 2 F80 R82 F80 R82 ? 0005576,0006952,0031410 P02883 20606256 604 ATFEIVNRCSYTVWAAASKGDAALDAGGRQLNSGESWTINVEPGTNGGKIWARTDCYFDDSGSGICKTGDCGGLLRCKRFGRPPTTLAEFSLNQYGKDYIDISNIKGFNVPMDFSPTTRGCRGVRCAADIVGQCPAKLKAPGGGCNDACTVFQTSEYCCTTGKCGPTEYSRFFKRLCPDAFSYVLDKPTTVTCPGSSNYRVTFCPTA 2pes A 1.6 BS02 PDC A 1 P202 K203 A206 Q242 P202 K203 A206 Q242 K10 T57 R176 Q228 H256 K10 T57 R176 Q228 H256 1.7.3.3 0004846,0005777,0006144,0006145,0016491,0019628 Q00511 20606256 302 SAVKAARYGKDNVRVYKVHKDEKTGVQTVYEMTVCVLLEGEIETSYTKADNSVIVATDSIKNTIYITAKQNPVTPPELFGSILGTHFIEKYNHIHAAHVNIVCHRWTRMDIDGKPHPHSFIRDSEEKRNVQVDVVEGKGIDIKSSLSGLTVLKSTNSQFWGFLRDEYTTLKETWDRILSTDVDATWQWKNFSGLQEVRSHVPKFDATWATAREVTLKTFAEDNSASVQATMYKMAEQILARQQLIETVEYSLPNKHYFEIDLSWHKGLQNTGKNAEVFAPQSDPNGLIKCTVGRS 2pes A 1.6 BS03 PDC A 2 S199 H200 K203 S199 H200 K203 K10 T57 R176 Q228 H256 K10 T57 R176 Q228 H256 1.7.3.3 0004846,0005777,0006144,0006145,0016491,0019628 Q00511 20606256 303 SAVKAARYGKDNVRVYKVHKDEKTGVQTVYEMTVCVLLEGEIETSYTKADNSVIVATDSIKNTIYITAKQNPVTPPELFGSILGTHFIEKYNHIHAAHVNIVCHRWTRMDIDGKPHPHSFIRDSEEKRNVQVDVVEGKGIDIKSSLSGLTVLKSTNSQFWGFLRDEYTTLKETWDRILSTDVDATWQWKNFSGLQEVRSHVPKFDATWATAREVTLKTFAEDNSASVQATMYKMAEQILARQQLIETVEYSLPNKHYFEIDLSWHKGLQNTGKNAEVFAPQSDPNGLIKCTVGRS 2pes A 1.6 BS04 PDC A 3 R164 D165 R164 D165 K10 T57 R176 Q228 H256 K10 T57 R176 Q228 H256 1.7.3.3 0004846,0005777,0006144,0006145,0016491,0019628 Q00511 20606256 306 SAVKAARYGKDNVRVYKVHKDEKTGVQTVYEMTVCVLLEGEIETSYTKADNSVIVATDSIKNTIYITAKQNPVTPPELFGSILGTHFIEKYNHIHAAHVNIVCHRWTRMDIDGKPHPHSFIRDSEEKRNVQVDVVEGKGIDIKSSLSGLTVLKSTNSQFWGFLRDEYTTLKETWDRILSTDVDATWQWKNFSGLQEVRSHVPKFDATWATAREVTLKTFAEDNSASVQATMYKMAEQILARQQLIETVEYSLPNKHYFEIDLSWHKGLQNTGKNAEVFAPQSDPNGLIKCTVGRS 3lgr A 1.64 BS01 PDC A 1 Q4 P5 N19 G21 G23 Q4 P5 N19 G21 G23 N44 Y77 E86 Y88 E177 N44 Y77 E86 Y88 E177 3.2.1.8 0004553,0005576,0005975,0016798,0031176,0045493 P36217 20606256 303 QTIQPGTGYNNGYFYSYWNDGHGGVTYTNGPGGQFSVNWSNSGNFVGGKGWQPGTKNKVINFSGSYNPNGNSYLSVYGWSRNPLIEYYIVENFGTYNPSTGATKLGEVTSDGSVYDIYRTQRVNQPSIIGTATFYQYWSVRRNHRSSGSVNTANHFNAWAQQGLTLGTMDYQIVAVEGYFSSGSASITVS 3lgr A 1.64 BS02 PDC A 2 Q4 Y17 Q4 Y17 N44 Y77 E86 Y88 E177 N44 Y77 E86 Y88 E177 3.2.1.8 0004553,0005576,0005975,0016798,0031176,0045493 P36217 20606256 304 QTIQPGTGYNNGYFYSYWNDGHGGVTYTNGPGGQFSVNWSNSGNFVGGKGWQPGTKNKVINFSGSYNPNGNSYLSVYGWSRNPLIEYYIVENFGTYNPSTGATKLGEVTSDGSVYDIYRTQRVNQPSIIGTATFYQYWSVRRNHRSSGSVNTANHFNAWAQQGLTLGTMDYQIVAVEGYFSSGSASITVS 3ojo A 2.5 BS02 PDC A 1 R211 Y314 K315 R211 Y305 K306 T119 P155 K204 N208 C258 D262 T119 P155 K204 N208 C258 D262 ? 0000166,0000271,0016491,0016616,0016628,0051287 P95708 21454499 502 SKLTVVGLGYIGLPTSIMFAKHGVDVLGVDINQQTIDKLQNGQISIEEPGLQEVYEEVLSSGKLKVSTTPEASDVFIIAVPTPNNDDQYRSCDISLVMRALDSILPFLKKGNTIIVESTIAPKTMDDFVKPVIENLGFTIGEDIYLVHCPERVLPGKILEELVHNNRIIGGVTKACIEAGKRVYRTFVQGEMIETDARTAEMSKLMENTYRDVNIALANELTKICNNLNINVLDVIEMANKHPRVNIHQPGPGVGGHCLAVDPNAKLIQTGREINNSMPAYVVDTTKQIIKALSGNKVTVFGLTYKGDVDDIRESPAFDIYELLNQEPDIEVCAYDPHVELDFVEHDMSHAVKDASLVLILSDHSEFKNLSDSHFDKMKHKVIFDTKNVVKSSFEDVLYYNYGNIFNFI 3ojo A 2.5 BS03 PDC A 2 R152 K315 R152 K306 T119 P155 K204 N208 C258 D262 T119 P155 K204 N208 C258 D262 ? 0000166,0000271,0016491,0016616,0016628,0051287 P95708 21454499 503 SKLTVVGLGYIGLPTSIMFAKHGVDVLGVDINQQTIDKLQNGQISIEEPGLQEVYEEVLSSGKLKVSTTPEASDVFIIAVPTPNNDDQYRSCDISLVMRALDSILPFLKKGNTIIVESTIAPKTMDDFVKPVIENLGFTIGEDIYLVHCPERVLPGKILEELVHNNRIIGGVTKACIEAGKRVYRTFVQGEMIETDARTAEMSKLMENTYRDVNIALANELTKICNNLNINVLDVIEMANKHPRVNIHQPGPGVGGHCLAVDPNAKLIQTGREINNSMPAYVVDTTKQIIKALSGNKVTVFGLTYKGDVDDIRESPAFDIYELLNQEPDIEVCAYDPHVELDFVEHDMSHAVKDASLVLILSDHSEFKNLSDSHFDKMKHKVIFDTKNVVKSSFEDVLYYNYGNIFNFI 3ojo A 2.5 BS04 PDC A 3 R152 E207 R211 R152 E207 R211 T119 P155 K204 N208 C258 D262 T119 P155 K204 N208 C258 D262 ? 0000166,0000271,0016491,0016616,0016628,0051287 P95708 21454499 504 SKLTVVGLGYIGLPTSIMFAKHGVDVLGVDINQQTIDKLQNGQISIEEPGLQEVYEEVLSSGKLKVSTTPEASDVFIIAVPTPNNDDQYRSCDISLVMRALDSILPFLKKGNTIIVESTIAPKTMDDFVKPVIENLGFTIGEDIYLVHCPERVLPGKILEELVHNNRIIGGVTKACIEAGKRVYRTFVQGEMIETDARTAEMSKLMENTYRDVNIALANELTKICNNLNINVLDVIEMANKHPRVNIHQPGPGVGGHCLAVDPNAKLIQTGREINNSMPAYVVDTTKQIIKALSGNKVTVFGLTYKGDVDDIRESPAFDIYELLNQEPDIEVCAYDPHVELDFVEHDMSHAVKDASLVLILSDHSEFKNLSDSHFDKMKHKVIFDTKNVVKSSFEDVLYYNYGNIFNFI 3ojo A 2.5 BS05 PDC B 2 H242 R244 H242 R244 T119 P155 K204 N208 C258 D262 T119 P155 K204 N208 C258 D262 ? 0000166,0000271,0016491,0016616,0016628,0051287 P95708 21454499 503 SKLTVVGLGYIGLPTSIMFAKHGVDVLGVDINQQTIDKLQNGQISIEEPGLQEVYEEVLSSGKLKVSTTPEASDVFIIAVPTPNNDDQYRSCDISLVMRALDSILPFLKKGNTIIVESTIAPKTMDDFVKPVIENLGFTIGEDIYLVHCPERVLPGKILEELVHNNRIIGGVTKACIEAGKRVYRTFVQGEMIETDARTAEMSKLMENTYRDVNIALANELTKICNNLNINVLDVIEMANKHPRVNIHQPGPGVGGHCLAVDPNAKLIQTGREINNSMPAYVVDTTKQIIKALSGNKVTVFGLTYKGDVDDIRESPAFDIYELLNQEPDIEVCAYDPHVELDFVEHDMSHAVKDASLVLILSDHSEFKNLSDSHFDKMKHKVIFDTKNVVKSSFEDVLYYNYGNIFNFI 3ojo B 2.5 BS01 PDC A 3 H242 R244 V245 H242 R244 V245 T119 P155 K204 N208 C258 D262 T119 P155 K204 N208 C258 D262 ? 0000166,0000271,0016491,0016616,0016628,0051287 P95708 21454499 504 SKLTVVGLGYIGLPTSIMFAKHGVDVLGVDINQQTIDKLQNGQISIEEPGLQEVYEEVLSSGKLKVSTTPEASDVFIIAVPTPNNDDQYRSCDISLVMRALDSILPFLKKGNTIIVESTIAPKTMDDFVKPVIENLGFTIGEDIYLVHCPERVLPGKILEELVHNNRIIGGVTKACIEAGKRVYRTFVQGEMIETDARTAEMSKLMENTYRDVNIALANELTKICNNLNINVLDVIEMANKHPRVNIHQPGPGVGGHCLAVDPYFIIAKDPENAKLIQTGREINNSMPAYVVDTTKQIIKALSGNKVTVFGLTYKGDVDDIRESPAFDIYELLNQEPDIEVCAYDPHVELDFVEHDMSHAVKDASLVLILSDHSEFKNLSDSHFDKMKHKVIFDTKNVVKSSFEDVLYYNYGNIFNFI 3ojo B 2.5 BS03 PDC B 1 R152 V153 K315 R152 V153 K315 T119 P155 K204 N208 C258 D262 T119 P155 K204 N208 C258 D262 ? 0000166,0000271,0016491,0016616,0016628,0051287 P95708 21454499 502 SKLTVVGLGYIGLPTSIMFAKHGVDVLGVDINQQTIDKLQNGQISIEEPGLQEVYEEVLSSGKLKVSTTPEASDVFIIAVPTPNNDDQYRSCDISLVMRALDSILPFLKKGNTIIVESTIAPKTMDDFVKPVIENLGFTIGEDIYLVHCPERVLPGKILEELVHNNRIIGGVTKACIEAGKRVYRTFVQGEMIETDARTAEMSKLMENTYRDVNIALANELTKICNNLNINVLDVIEMANKHPRVNIHQPGPGVGGHCLAVDPYFIIAKDPENAKLIQTGREINNSMPAYVVDTTKQIIKALSGNKVTVFGLTYKGDVDDIRESPAFDIYELLNQEPDIEVCAYDPHVELDFVEHDMSHAVKDASLVLILSDHSEFKNLSDSHFDKMKHKVIFDTKNVVKSSFEDVLYYNYGNIFNFI 3ojo B 2.5 BS04 PDC B 2 R152 E207 N208 R211 R152 E207 N208 R211 T119 P155 K204 N208 C258 D262 T119 P155 K204 N208 C258 D262 ? 0000166,0000271,0016491,0016616,0016628,0051287 P95708 21454499 503 SKLTVVGLGYIGLPTSIMFAKHGVDVLGVDINQQTIDKLQNGQISIEEPGLQEVYEEVLSSGKLKVSTTPEASDVFIIAVPTPNNDDQYRSCDISLVMRALDSILPFLKKGNTIIVESTIAPKTMDDFVKPVIENLGFTIGEDIYLVHCPERVLPGKILEELVHNNRIIGGVTKACIEAGKRVYRTFVQGEMIETDARTAEMSKLMENTYRDVNIALANELTKICNNLNINVLDVIEMANKHPRVNIHQPGPGVGGHCLAVDPYFIIAKDPENAKLIQTGREINNSMPAYVVDTTKQIIKALSGNKVTVFGLTYKGDVDDIRESPAFDIYELLNQEPDIEVCAYDPHVELDFVEHDMSHAVKDASLVLILSDHSEFKNLSDSHFDKMKHKVIFDTKNVVKSSFEDVLYYNYGNIFNFI 4ih3 A 2.493 BS02 PDC A 1 H8 R47 P77 H174 W191 D291 L296 H8 R47 P77 H174 W191 D291 L296 4.1.1.45 0001760,0005515,0005737,0005829,0006569,0008270,0016787,0016831,0019748,0046872,1904985,1905004,1905012 -logKd/Ki=4.82, Ki=15.2uM Q8TDX5 25392945 402 MKIDIHSHILPKEWPDLKKRFGYGGWVQLQHHSKGEAKLLKDGKVFRVVRENCWDPEVRIREMDQKGVTVQALSTVPVMFSYWAKPEDTLNLCQLLNNDLASTVVSYPRRFVGLGTLPMQAPELAVKEMERCVKELGFPGVQIGTHVNEWDLNAQELFPVYAAAERLKCSLFVHPWDMQMDGRMAKYWLPWLVGMPAETTIAICSMIMGGVFEKFPKLKVCFAHGGGAFPFTVGRISHGFSMRPDLCAQDNPMNPKKYLGSFYTDALVHDPLSLKLLTDVIGKDKVILGTDYPFPLGELEPGKLIESMEEFDEETKNKLKAGNALAFLGLER 4ih3 B 2.493 BS02 PDC B 1 H8 R47 P77 V78 H174 W191 D291 H8 R47 P77 V78 H174 W191 D291 4.1.1.45 0001760,0005515,0005737,0005829,0006569,0008270,0016787,0016831,0019748,0046872,1904985,1905004,1905012 Q8TDX5 25392945 402 MKIDIHSHILPKEWPDLKKRFGYGGWVQLQHHSKGEAKLLKDGKVFRVVRENCWDPEVRIREMDQKGVTVQALSTVPVMFSYWAKPEDTLNLCQLLNNDLASTVVSYPRRFVGLGTLPMQAPELAVKEMERCVKELGFPGVQIGTHVNEWDLNAQELFPVYAAAERLKCSLFVHPWDMQMDGRMAKYWLPWLVGMPAETTIAICSMIMGGVFEKFPKLKVCFAHGGGAFPFTVGRISHGFSMRPDLCAQDNPMNPKKYLGSFYTDALVHDPLSLKLLTDVIGKDKVILGTDYPFPLGELEPGKLIESMEEFDEETKNKLKAGNALAFLGLER 4ih3 C 2.493 BS02 PDC C 1 H8 R47 P77 H174 W191 D291 F294 H8 R47 P77 H174 W191 D291 F294 4.1.1.45 0001760,0005515,0005737,0005829,0006569,0008270,0016787,0016831,0019748,0046872,1904985,1905004,1905012 Q8TDX5 25392945 402 MKIDIHSHILPKEWPDLKKRFGYGGWVQLQHHSKGEAKLLKDGKVFRVVRENCWDPEVRIREMDQKGVTVQALSTVPVMFSYWAKPEDTLNLCQLLNNDLASTVVSYPRRFVGLGTLPMQAPELAVKEMERCVKELGFPGVQIGTHVNEWDLNAQELFPVYAAAERLKCSLFVHPWDMQMDGRMAKYWLPWLVGMPAETTIAICSMIMGGVFEKFPKLKVCFAHGGGAFPFTVGRISHGFSMRPDLCAQDNPMNPKKYLGSFYTDALVHDPLSLKLLTDVIGKDKVILGTDYPFPLGELEPGKLIESMEEFDEETKNKLKAGNALAFLGLER 4ih3 D 2.493 BS02 PDC D 1 H8 F46 R47 P77 H174 W191 M195 H224 D291 L296 H8 F46 R47 P77 H174 W191 M195 H224 D291 L296 4.1.1.45 0001760,0005515,0005737,0005829,0006569,0008270,0016787,0016831,0019748,0046872,1904985,1905004,1905012 Q8TDX5 25392945 402 MKIDIHSHILPKEWPDLKKRFGYGGWVQLQHHSKGEAKLLKDGKVFRVVRENCWDPEVRIREMDQKGVTVQALSTVPVMFSYWAKPEDTLNLCQLLNNDLASTVVSYPRRFVGLGTLPMQAPELAVKEMERCVKELGFPGVQIGTHVNEWDLNAQELFPVYAAAERLKCSLFVHPWDMQMDGRMAKYWLPWLVGMPAETTIAICSMIMGGVFEKFPKLKVCFAHGGGAFPFTVGRISHGFSMRPDLCAQDNPMNPKKYLGSFYTDALVHDPLSLKLLTDVIGKDKVILGTDYPFPLGELEPGKLIESMEEFDEETKNKLKAGNALAFLGLER 4ih3 E 2.493 BS02 PDC E 1 R47 P77 H174 W191 D291 F294 L296 R47 P77 H174 W191 D291 F294 L296 4.1.1.45 0001760,0005515,0005737,0005829,0006569,0008270,0016787,0016831,0019748,0046872,1904985,1905004,1905012 Q8TDX5 25392945 402 MKIDIHSHILPKEWPDLKKRFGYGGWVQLQHHSKGEAKLLKDGKVFRVVRENCWDPEVRIREMDQKGVTVQALSTVPVMFSYWAKPEDTLNLCQLLNNDLASTVVSYPRRFVGLGTLPMQAPELAVKEMERCVKELGFPGVQIGTHVNEWDLNAQELFPVYAAAERLKCSLFVHPWDMQMDGRMAKYWLPWLVGMPAETTIAICSMIMGGVFEKFPKLKVCFAHGGGAFPFTVGRISHGFSMRPDLCAQDNPMNPKKYLGSFYTDALVHDPLSLKLLTDVIGKDKVILGTDYPFPLGELEPGKLIESMEEFDEETKNKLKAGNALAFLGLER 4ih3 F 2.493 BS02 PDC F 1 R47 P77 H174 W191 D291 L296 R47 P77 H174 W191 D291 L296 4.1.1.45 0001760,0005515,0005737,0005829,0006569,0008270,0016787,0016831,0019748,0046872,1904985,1905004,1905012 -logKd/Ki=4.82, Ki=15.2uM Q8TDX5 25392945 402 MKIDIHSHILPKEWPDLKKRFGYGGWVQLQHHSKGEAKLLKDGKVFRVVRENCWDPEVRIREMDQKGVTVQALSTVPVMFSYWAKPEDTLNLCQLLNNDLASTVVSYPRRFVGLGTLPMQAPELAVKEMERCVKELGFPGVQIGTHVNEWDLNAQELFPVYAAAERLKCSLFVHPWDMQMDGRMAKYWLPWLVGMPAETTIAICSMIMGGVFEKFPKLKVCFAHGGGAFPFTVGRISHGFSMRPDLCAQDNPMNPKKYLGSFYTDALVHDPLSLKLLTDVIGKDKVILGTDYPFPLGELEPGKLIESMEEFDEETKNKLKAGNALAFLGLER 4irw A 1.396 BS01 PDC A 1 G38 N39 G38 N39 ? 0009374 P22629 203 GAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKV 4irw A 1.396 BS02 PDC A 2 N71 N72 Y73 N75 N71 N72 Y73 N75 ? 0009374 P22629 204 GAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKV 4irw A 1.396 BS03 PDC A 3 E34 E41 S42 E34 E41 S42 ? 0009374 P22629 205 GAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKV 4irw A 1.396 BS04 PDC A 4 E41 S42 Y73 E41 S42 Y73 ? 0009374 P22629 206 GAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKV 4irw A 1.396 BS05 PDC A 5 N39 L114 N39 L114 ? 0009374 P22629 210 GAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKV 4irw A 1.396 BS06 PDC A 6 D26 R49 D26 R49 ? 0009374 P22629 211 GAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKV 4irw A 1.396 BS07 PDC A 7 A28 R49 A28 R49 ? 0009374 P22629 212 GAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKV 5cq6 A 1.97 BS01 PDC A 1 K1896 K1902 K41 K47 ? Q9UIF8 2003 SMSVKKPKRDDSKDLALCSMILTEMETHEDAWPFLLPVNLKLVPGYKKVIKKPMDFSTIREKLSSGQYPNLETFALDVRLVFDNCETFNEDDSDIGRAGHNMRKYFEKKWTDTFK 5tem A 2.2 BS02 PDC A 1 T100 P123 H156 K159 S164 G165 T166 T100 P123 H156 K159 S164 G165 T166 H155 K159 H155 K159 1.17.1.8 0005737,0005829,0008839,0009085,0009089,0016491,0016726,0019877,0050661,0051287 Q8DEM0 32980502 1002 MVRIAVAGAAGRMGRNLVKAAHHNPVAKVAAGSERPESSLVGVDLGELCGEGKFDVVVCDDLAKQIDQFDVIIDFTAPASTLNNLALCQQYGKSIVIGTTGFTEEQREQIDLVAQQVPVVMAPNYSVGVNLVFKLLEKAAKVMGDYCDIEIVEAHHRHKVDAPSGTAIGMGEAIAGAMGNKLSDVAVYAREGITGERTKDEIGFATIRAGDIVGEHTAMFADIGERVEITHKATDRMTFANGAVKAAVWLHEKPAGFYTMTDVLGL 5tem C 2.2 BS02 PDC C 1 T100 P123 H156 K159 S164 G165 T166 T100 P123 H156 K159 S164 G165 T166 1.17.1.8 0005737,0005829,0008839,0009085,0009089,0016491,0016726,0019877,0050661,0051287 Q8DEM0 32980502 1002 MVRIAVAGAAGRMGRNLVKAAHHNPVAKVAAGSERPESSLVGVDLGELCGEGKFDVVVCDDLAKQIDQFDVIIDFTAPASTLNNLALCQQYGKSIVIGTTGFTEEQREQIDLVAQQVPVVMAPNYSVGVNLVFKLLEKAAKVMGDYCDIEIVEAHHRHKVDAPSGTAIGMGEAIAGAMGNKLSDVAVYAREGITGERTKDEIGFATIRAGDIVGEHTAMFADIGERVEITHKATDRMTFANGAVKAAVWLHEKPAGFYTMTDVLGL 5tjy A 2.4 BS01 PDC A 1 T77 P103 H133 K136 S141 G142 T143 A192 T78 P104 H134 K137 S142 G143 T144 A193 H132 K136 H133 K137 1.17.1.8 0005737,0005829,0008839,0009085,0009089,0016491,0016726,0019877,0050661,0051287 A5U6C6 32980502 301 GMRVGVLGAKGKVGATMVRAVAAADDLTLSAELDAGDPLSLLTDGNTEVVIDFTHPDVVMGNLEFLIDNGIHAVVGTTGFTAERFQQVESWLVAKPNTSVLIAPNFAIGAVLSMHFAKQAARFFDSAEVIELHHPHKADAPSGTAARTAKLIAEARKGLPPNPDATSTSLPGARGADVDGIPVHAVRLAGLVAHQEVLFGTEGETLTIRHDSLDRTSFVPGVLLAVRRIAERPGLTVGLEPLLDL 5tjz A 1.5 BS01 PDC A 1 T77 P103 H133 K136 S141 G142 T143 A192 T78 P104 H134 K137 S142 G143 T144 A193 H132 K136 H133 K137 1.17.1.8 0005737,0005829,0005886,0008839,0009085,0009089,0009274,0016491,0016726,0019877,0050661,0051287,0070402,0070404 P9WP23 32980502 301 GMRVGVLGAKGKVGATMVRAVAAADDLTLSAELDAGDPLSLLTDGNTEVVIDFTHPDVVMGNLEFLIDNGIHAVVGTTGFTAERFQQVESWLVAKPNTSVLIAPNFAIGAVLSMHFAKQAARFFDSAEVIELHHPHKADAPSGTAARTAKLIAEARKGLPPNPDATSTSLPGARGADVDGIPVHAVRLAGLVAHQEVLFGTEGETLTIRHDSLDRTSFVPGVLLAVRRIAERPGLTVGLEPLLDL 5us6 A 2.61 BS02 PDC A 1 T100 P123 H156 K159 S164 G165 T166 T100 P123 H156 K159 S164 G165 T166 1.17.1.8 0005737,0005829,0008839,0009085,0009089,0016491,0016726,0019877,0050661,0051287 Q8DEM0 32980502 1002 MVRIAVAGAAGRMGRNLVKAAHHNPVAKVAAGSERPESSLVGVDLGELCGEGKFDVVVCDDLAKQIDQFDVIIDFTAPASTLNNLALCQQYGKSIVIGTTGFTEEQREQIDLVAQQVPVVMAPNYSVGVNLVFKLLEKAAKVMGDYCDIEIVEAHHRHKVDAPSGTAIGMGEAIAGAMGNKLSDVAVYAREGITGERTKDEIGFATIRAGDIVGEHTAMFADIGERVEITHKATDRMTFANGAVKAAVWLHEKPAGFYTMTDVLGLN 5us6 B 2.61 BS02 PDC B 1 T100 P123 H156 K159 S164 G165 T166 T101 P124 H157 K160 S165 G166 T167 1.17.1.8 0005737,0005829,0008839,0009085,0009089,0016491,0016726,0019877,0050661,0051287 Q8DEM0 32980502 1002 GMVRIAVAGAAGRMGRNLVKAAHHNPVAKVAAGSERPESSLVGVDLGELCGEGKFDVVVCDDLAKQIDQFDVIIDFTAPASTLNNLALCQQYGKSIVIGTTGFTEEQREQIDLVAQQVPVVMAPNYSVGVNLVFKLLEKAAKVMGDYCDIEIVEAHHRHKVDAPSGTAIGMGEAIAGAMGNKLSDVAVYAREGITGERTKDEIGFATIRAGDIVGEHTAMFADIGERVEITHKATDRMTFANGAVKAAVWLHEKPAGFYTMTDVLG 5us6 C 2.61 BS02 PDC C 1 T100 P123 H156 K159 S164 G165 T166 T100 P123 H156 K159 S164 G165 T166 1.17.1.8 0005737,0005829,0008839,0009085,0009089,0016491,0016726,0019877,0050661,0051287 Q8DEM0 32980502 1002 MVRIAVAGAAGRMGRNLVKAAHHNPVAKVAAGSERPESSLVGVDLGELCGEGKFDVVVCDDLAKQIDQFDVIIDFTAPASTLNNLALCQQYGKSIVIGTTGFTEEQREQIDLVAQQVPVVMAPNYSVGVNLVFKLLEKAAKVMGDYCDIEIVEAHHRHKVDAPSGTAIGMGEAIAGAMGNKLSDVAVYAREGITGERTKDEIGFATIRAGDIVGEHTAMFADIGERVEITHKATDRMTFANGAVKAAVWLHEKPAGFYTMTDVLGL 5us6 E 2.61 BS02 PDC E 1 T100 P123 H156 K159 S164 G165 T166 F239 T100 P123 H156 K159 S164 G165 T166 F239 1.17.1.8 0005737,0005829,0008839,0009085,0009089,0016491,0016726,0019877,0050661,0051287 Q8DEM0 32980502 1002 MVRIAVAGAAGRMGRNLVKAAHHNPVAKVAAGSERPESSLVGVDLGELCGEGKFDVVVCDDLAKQIDQFDVIIDFTAPASTLNNLALCQQYGKSIVIGTTGFTEEQREQIDLVAQQVPVVMAPNYSVGVNLVFKLLEKAAKVMGDYCDIEIVEAHHRHKVDAPSGTAIGMGEAIAGAMGNKLSDVAVYAREGITGERTKDEIGFATIRAGDIVGEHTAMFADIGERVEITHKATDRMTFANGAVKAAVWLHEKPAGFYTMTDVLGLN 5us6 F 2.61 BS02 PDC F 1 T100 P123 H156 K159 S164 G165 T166 T101 P124 H157 K160 S165 G166 T167 1.17.1.8 0005737,0005829,0008839,0009085,0009089,0016491,0016726,0019877,0050661,0051287 Q8DEM0 32980502 1002 GMVRIAVAGAAGRMGRNLVKAAHHNPVAKVAAGSERPESSLVGVDLGELCGEGKFDVVVCDDLAKQIDQFDVIIDFTAPASTLNNLALCQQYGKSIVIGTTGFTEEQREQIDLVAQQVPVVMAPNYSVGVNLVFKLLEKAAKVMGDYCDIEIVEAHHRHKVDAPSGTAIGMGEAIAGAMGNKLSDVAVYAREGITGERTKDEIGFATIRAGDIVGEHTAMFADIGERVEITHKATDRMTFANGAVKAAVWLHEKPAGFYTMTDVLG 5us6 G 2.61 BS02 PDC G 1 T100 P123 H156 K159 S164 G165 T166 T100 P123 H156 K159 S164 G165 T166 1.17.1.8 0005737,0005829,0008839,0009085,0009089,0016491,0016726,0019877,0050661,0051287 Q8DEM0 32980502 1002 MVRIAVAGAAGRMGRNLVKAAHHNPVAKVAAGSERPESSLVGVDLGELCGEGKFDVVVCDDLAKQIDQFDVIIDFTAPASTLNNLALCQQYGKSIVIGTTGFTEEQREQIDLVAQQVPVVMAPNYSVGVNLVFKLLEKAAKVMGDYCDIEIVEAHHRHKVDAPSGTAIGMGEAIAGAMGNKLSDVAVYAREGITGERTKDEIGFATIRAGDIVGEHTAMFADIGERVEITHKATDRMTFANGAVKAAVWLHEKPAGFYTMTDVLGL 5us6 I 2.61 BS01 PDC I 1 T100 H156 K159 S164 G165 T166 F239 T100 H156 K159 S164 G165 T166 F239 1.17.1.8 0005737,0005829,0008839,0009085,0009089,0016491,0016726,0019877,0050661,0051287 Q8DEM0 32980502 301 MVRIAVAGAAGRMGRNLVKAAHHNPVAKVAAGSERPESSLVGVDLGELCGEGKFDVVVCDDLAKQIDQFDVIIDFTAPASTLNNLALCQQYGKSIVIGTTGFTEEQREQIDLVAQQVPVVMAPNYSVGVNLVFKLLEKAAKVMGDYCDIEIVEAHHRHKVDAPSGTAIGMGEAIAGAMGNKLSDVAVYAREGITGERTKDEIGFATIRAGDIVGEHTAMFADIGERVEITHKATDRMTFANGAVKAAVWLHEKPAGFYTMTDVLGLN 5us6 J 2.61 BS02 PDC J 1 T100 P123 H156 K159 S164 G165 T166 T101 P124 H157 K160 S165 G166 T167 1.17.1.8 0005737,0005829,0008839,0009085,0009089,0016491,0016726,0019877,0050661,0051287 Q8DEM0 32980502 1002 GMVRIAVAGAAGRMGRNLVKAAHHNPVAKVAAGSERPESSLVGVDLGELCGEGKFDVVVCDDLAKQIDQFDVIIDFTAPASTLNNLALCQQYGKSIVIGTTGFTEEQREQIDLVAQQVPVVMAPNYSVGVNLVFKLLEKAAKVMGDYCDIEIVEAHHRHKVDAPSGTAIGMGEAIAGAMGNKLSDVAVYAREGITGERTKDEIGFATIRAGDIVGEHTAMFADIGERVEITHKATDRMTFANGAVKAAVWLHEKPAGFYTMTDVLGL 5us6 K 2.61 BS02 PDC K 1 T100 H156 K159 G165 T166 F239 T100 H156 K159 G165 T166 F239 1.17.1.8 0005737,0005829,0008839,0009085,0009089,0016491,0016726,0019877,0050661,0051287 Q8DEM0 32980502 1002 MVRIAVAGAAGRMGRNLVKAAHHNPVAKVAAGSERPESSLVGVDLGELCGEGKFDVVVCDDLAKQIDQFDVIIDFTAPASTLNNLALCQQYGKSIVIGTTGFTEEQREQIDLVAQQVPVVMAPNYSVGVNLVFKLLEKAAKVMGDYCDIEIVEAHHRHKVDAPSGTAIGMGEAIAGAMGNKLSDVAVYAREGITGERTKDEIGFATIRAGDIVGEHTAMFADIGERVEITHKATDRMTFANGAVKAAVWLHEKPAGFYTMTDVLGL 5z2e A 1.8 BS01 PDC A 1 H154 H155 K158 S163 G164 T165 H155 H156 K159 S164 G165 T166 1.17.1.8 0000166,0005737,0005829,0008839,0009085,0009089,0016491,0016726,0019877,0050661,0051287 A0A3B6UER2 29786696 301 MMIRVAIGGPRGKMGQEAVHTVMNNENMELVAVLDHKDIGDLLSESPNFPASYEVPVFLNLESLIVTIKPDVFLDLTTPHQVFEHTMLCLQNNVRPVIGTTGFTDEQLQQCTILAEVNKLGCIVAPNFAIGAVLMMKFASLAAAYFPDVEIIEMHHDQKLDAPSGTAYKTAQMIAEVRPSHKQGHPNEKETLEGARGASYDGIPIHSVRLPGLIAHQQILFGGEGQLFTLRHDSYNRQSFMSGVTFSINQVMEIKELVYGLENIL 5z2f A 2.1 BS02 PDC A 1 P125 H154 H155 K158 S163 G164 T165 A214 P126 H155 H156 K159 S164 G165 T166 A215 1.17.1.8 0000166,0005737,0005829,0008839,0009085,0009089,0016491,0016726,0019877,0050661,0051287 A0A3B6UER2 29786696 302 MMIRVAIGGPRGKMGQEAVHTVMNNENMELVAVLDHKDIGDLLSESPNFPASYEVPVFLNLESLIVTIKPDVFLDLTTPHQVFEHTMLCLQNNVRPVIGTTGFTDEQLQQCTILAEVNKLGCIVAPNFAIGAVLMMKFASLAAAYFPDVEIIEMHHDQKLDAPSGTAYKTAQMIAEVRPSHKQGHPNEKETLEGARGASYDGIPIHSVRLPGLIAHQQILFGGEGQLFTLRHDSYNRQSFMSGVTFSINQVMEIKELVYGLENIL 8s3a E 1.85 BS01 PDC E 1 K66 M87 K90 K102 A140 P141 D142 R181 N312 S344 K67 M88 K91 K103 A141 P142 D143 R182 N313 S345 G7JYL4 39142482 1102 AMNALVATNRNFQRASRILGLDSKLEKSLLIPYREIKVECTIPKDDGSLVSYVGFRIQHDNARGPMKGGIRYHPEVDPDEVNALAQLMTWKTAVVDIPYGGAKGGIGCNPKDLSISELERLTRVFTQKIHDLIGIHRDVPAPDMGTNSQTMAWILDEYSKFHGHSPAVVTGKPIDLGGSLGREAATGLGVVFATEALFAEYGKSISDMTFAIQGFGNVGTWAAKAIFERGGKVVAVSDINGAISNPNGIDIAALLKHKAGNGSLKDFSGGDAMNPNDLLVHDCDVLIPCALGGVLNKENANDVKAKFIIEAANHPTDPDADEILSKKGVIILPDVYANAGGVTVSYFEWVQNIQGFMWDEEKVNQELKRYMTKAFNDIKANCKTHNCDLRMGAFTLGLNRVARATLLRGWEA 8s3a F 1.85 BS01 PDC F 1 K66 M87 K90 K102 A140 P141 D142 R181 N312 S344 K68 M89 K92 K104 A142 P143 D144 R183 N314 S346 G7JYL4 39142482 601 NAMNALVATNRNFQRASRILGLDSKLEKSLLIPYREIKVECTIPKDDGSLVSYVGFRIQHDNARGPMKGGIRYHPEVDPDEVNALAQLMTWKTAVVDIPYGGAKGGIGCNPKDLSISELERLTRVFTQKIHDLIGIHRDVPAPDMGTNSQTMAWILDEYSKFHGHSPAVVTGKPIDLGGSLGREAATGLGVVFATEALFAEYGKSISDMTFAIQGFGNVGTWAAKAIFERGGKVVAVSDINGAISNPNGIDIAALLKHKAGNGSLKDFSGGDAMNPNDLLVHDCDVLIPCALGGVLNKENANDVKAKFIIEAANHPTDPDADEILSKKGVIILPDVYANAGGVTVSYFEWVQNIQGFMWDEEKVNQELKRYMTKAFNDIKANCKTHNCDLRMGAFTLGLNRVARATLLRGWEA