1afk A 1.7 BS01 PAP A 1 K7 Q11 H12 C65 N67 Q69 N71 A109 E111 V118 H119 K7 Q11 H12 C65 N67 Q69 N71 A109 E111 V118 H119 H12 K41 H119 F120 D121 H12 K41 H119 F120 D121 4.6.1.18 0003676,0004519,0004522,0004540,0005515,0005576,0016829,0050830 Ki=240nM -logKd/Ki=6.62, Ki=240nM P61823 9154942 125 KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV 1afk B 1.7 BS01 PAP B 1 A4 K7 Q11 H12 C65 N67 Q69 N71 A109 V118 H119 F120 A4 K7 Q11 H12 C65 N67 Q69 N71 A109 V118 H119 F120 H12 K41 H119 F120 D121 H12 K41 H119 F120 D121 4.6.1.18 0003676,0004519,0004522,0004540,0005515,0005576,0016829,0050830 Ki=240nM P61823 9154942 125 KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHFDASV 1m4d A 1.8 BS03 PAP A 1 H54 H55 W90 Q93 H54 H55 W90 Q93 2.3.1.- 0005886,0016746,0016747,0030649,0034069,0046677,0047921 P9WQG9 12161746 602 MHTQVHTARLVHTADLDSETRQDIRQMVTGAFAGDFTETDWEHTLGGMHALIWHHGAIIAHAAVIQRRLIYRGNALRCGYVEGVAVRADWRGQRLVSALLDAVEQVMRGAYQLGALSSSARARRLYASRGWLPWHGPTSVLAPTGPVRTPDDDGTVFVLPIDISLDTSAELMCDWRAGDVW 1m4g B 1.8 BS03 PAP B 1 S119 A120 R121 R123 S114 A115 R116 R118 2.3.1.- 0005886,0016746,0016747,0030649,0034069,0046677,0047921 P9WQG9 12161746 600 HTARLVHTADLDSETRQDIRQMVTGAFAGDFTETDWEHTLGGMHALIWHHGAIIAHAAVIQRRLIYRGNALRCGYVEGVAVRADWRGQRLVSALLDAVEQVMRGAYQLGALSSSARARRLYASRGWLPWHGPTSVLAPTGPVRTPDDDGTVFVLPIDISLDTSAELMCDWRAGDVW 1m4i A 1.5 BS03 PAP A 1 H54 H55 D89 W90 Q93 H54 H55 D89 W90 Q93 2.3.1.- 0005886,0016746,0016747,0030649,0034069,0046677,0047921 P9WQG9 12161746 602 MHTQVHTARLVHTADLDSETRQDIRQMVTGAFAGDFTETDWEHTLGGMHALIWHHGAIIAHAAVIQRRLIYRGNALRCGYVEGVAVRADWRGQRLVSALLDAVEQVMRGAYQLGALSSSARARRLYASRGWLPWHGPTSVLAPTGPVRTPDDDGTVFVLPIDISLDTSAELMCDWRAGDVW 3mgb A 2.04 BS03 PAP A 1 K12 G14 N15 T16 W17 R90 S98 R101 Y167 S203 T204 L205 M208 F243 G245 G247 K23 G25 N26 T27 W28 R101 S109 R112 Y178 S214 T215 L216 M219 F244 G246 G248 K12 H67 S98 K23 H78 S109 2.8.2.- 0005737,0008146,0016740,0042277,0051923 B7T1D7 20361791 286 SSHHHHHHSSSMNGIRWIASYPKAGNTWVRCMLAAYITGKAPQVWNDIDAESLTLEAMLRFGDLPPAEPMEPVLVKTHLKADVPVLGLYGEATAKVLYLVRNPRDMLLSSMRMASISRDDVEKSRDFARKFIANEGLGWNALGAGGGVGLGSWPENVRSWTESSSDRFPNADVLTMRYEDLKGDPVARFSEIVEFLDLGGPVDIEDIRRAVAASTLERMRELEKRSGGSPIMMKGGPGGARPQFVGEGRYDQSLSFLGEDIESDYQELLHGDSGFALYAKQYGYAG 3mgb B 2.04 BS01 PAP B 1 K12 G14 N15 T16 W17 R90 S98 R101 Y167 T204 L205 M208 F243 G245 G247 K12 G14 N15 T16 W17 R90 S98 R101 Y161 T198 L199 M202 F222 G224 G226 K12 H67 S98 K12 H67 S98 2.8.2.- 0005737,0008146,0016740,0042277,0051923 B7T1D7 20361791 286 MNGIRWIASYPKAGNTWVRCMLAAYITGKAPQVWNDIDAESLTLEAMLRFGDLPPAEPMEPVLVKTHLKADVPVLGLYGEATAKVLYLVRNPRDMLLSSMRMASISRDDVEKSRDFARKFIANEGLGWNGVGLGSWPENVRSWTESSSDRFPNADVLTMRYEDLKGDPVARFSEIVEFLDLGGPVDIEDIRRAVAASTLERMRELEKRSEQQGGGSPIRPQFVGEGRYDQSLSFLGEDIESDYQELLHGDSGFALYAKQYGYAG 5mex A 1.92 BS01 PAP A 1 K93 G95 T96 T97 W98 R177 S185 Y243 F284 Y311 F312 R313 K314 K68 G70 T71 T72 W73 R152 S160 Y218 F259 Y286 F287 R288 K289 K93 H155 S185 K68 H130 S160 2.8.2.38 0005737,0008146,0016740,0019761,0047364,0080066,0080067,0080068,0080069,0080070,0080071 Q9C9C9 28646214 401 ESTEFEKNQKRYQDLISTFPHEKGWRPKEPLIEYGGYWWLPSLLEGCIHAQEFFQARPSDFLVCSYPKTGTTWLKALTFAIANRSRFDDSSNPLLKRNPHEFVPYIEIDFPFFPEVDVLKDKGNTLFSTHIPYELLPDSVVKSGCKMVYIWREPKDTFISMWTFLHKERTELGPVSNLEESFDMFCRGLSGYGPYLNHILAYWKAYQENPDRILFLKYETMRADPLPYVKSLAEFMGHGFTAEEEEKGVVEKVVNLCSFETLKNLEANKGEKDREDRPGVYANSAYFRKGKVGDWSNYLTPEMAARIDGLMEEKFKGTGLLE 6bml B 2.95 BS03 PAP B 1 K135 H140 H141 S143 K130 H135 H136 S138 2.3.1.-,2.3.1.225 0016409 Q5W0Z9 29326245 404 LWRCCQRVVGWVPVLFITFVVVWSYYAYVVELCVFTIFGNEENGKTVVYLVAFHLFFVMFVWSYWMTIFTSPASPSKEFYLSNSEKERYEKEFSQERQQEILRRAARALPIYTTSASKTIRYCEKCQLIKPDRAHHCSACDSCILKMDHHCPWVNNCVGFSNYKFFLLFLLYSLLYCLFVAATVLEYFIKFWTNELTDTRAKFHVLFLFFVSAMFFISVLSLFSYHCWLVGKNRTTIESFRAPTFSYGPDGNGFSLGASKNWRQVFGDEKKYWLLPIFSSLGDGCSFPTRLVGM 6bmn B 2.25 BS03 PAP B 1 K135 H140 H141 S143 K130 H135 H136 S138 2.3.1.-,2.3.1.225 0016409 Q5W0Z9 29326245 403 LWRCCQRVVGWVPVLFITFVVVWSYYAYVVELCVFTIFGNEENGKTVVYLVAFHLFFVMFVWSYWMTIFTSPASPSKEFYLSNSEKERYEKEFSQERQQEILRRAARALPIYTTSASKTIRYCEKCQLIKPDRAHHCSACDSCILKMDHHCPWVNNCVGFSNYKFFLLFLLYSLLYCLFVAATVLEYFIKFWTNELTDTRAKFHVLFLFFVSAMFFISVLSLFSYHCWLVGKNRTTIESFRAPTFSYGPDGNGFSLGCSKNWRQVFGDEKKYWLLPIFSSLGDGCSFPTRLVGM 8a56 A 2.05 BS02 PAP A 1 T17 R18 R21 F70 R305 T17 R18 R21 F70 R305 ? 0000166,0016491 Q82ZQ9 36009332 607 GKIVIIGGVAGGMSAATRLRRLMEDAEIVVMEKGPFVSFANCGLPYYVSGEIAEREQLLVQTPEALKARFNLDVRPHHEVVAIDPIEKVITVKHETEILTEHYDKLILSPGAKPFVPPITGLAEAKNVFSLRNVPDLDQIMTALTPETKRAVVIGAGFIGLEMAENLQKRGLEVTLVEKAPHVLPPLDEEMAAFVKAELSKNNVQVITGQSAVAFEEEGQVIRLEDGQTLASDLTILSVGVQPENTLAVEAGVATGLRGGIVVDEHYQTNQPDIYAVGDAIVVKQQITQEDALISLASPANRQGRQVADVIAGLERKNQGSIGTAIVRVFDLTAASTGLSERAAKAAGLTTAVVHISGKDHAGYYPGATDLQLKLVFHPTTGEIYGAQGIGAKGVDKRIDILATAIKGQLTIFDLPELEFTYAPPFGSAKDPVNMLGYAAMNLVEGLSENVQWYELSNELAKGAVLLDVRNPAQFKNAVSIPLNELRERLEELDKSTEYIVSCHSGLRSYIAERMLKQAGISAKNLDGAFALYRMVKP 8a56 A 2.05 BS03 PAP B 1 I356 K430 M435 Y438 G511 L512 Y515 I356 K430 M435 Y438 G506 L507 Y510 ? 0000166,0016491 Q82ZQ9 36009332 601 GKIVIIGGVAGGMSAATRLRRLMEDAEIVVMEKGPFVSFANCGLPYYVSGEIAEREQLLVQTPEALKARFNLDVRPHHEVVAIDPIEKVITVKHETEILTEHYDKLILSPGAKPFVPPITGLAEAKNVFSLRNVPDLDQIMTALTPETKRAVVIGAGFIGLEMAENLQKRGLEVTLVEKAPHVLPPLDEEMAAFVKAELSKNNVQVITGQSAVAFEEEGQVIRLEDGQTLASDLTILSVGVQPENTLAVEAGVATGLRGGIVVDEHYQTNQPDIYAVGDAIVVKQQITQEDALISLASPANRQGRQVADVIAGLERKNQGSIGTAIVRVFDLTAASTGLSERAAKAAGLTTAVVHISGKDHAGYYPGATDLQLKLVFHPTTGEIYGAQGIGAKGVDKRIDILATAIKGQLTIFDLPELEFTYAPPFGSAKDPVNMLGYAAMNLVEGLSENVQWYELSNELAKGAVLLDVRNPAQFKNAVSIPLNELRERLEELDKSTEYIVSCHSGLRSYIAERMLKQAGISAKNLDGAFALYRMVKP 8a56 B 2.05 BS02 PAP A 1 I356 K430 M435 Y438 G511 L512 Y515 I356 K430 M435 Y438 G505 L506 Y509 ? 0000166,0016491 Q82ZQ9 36009332 607 GKIVIIGGVAGGMSAATRLRRLMEDAEIVVMEKGPFVSFANCGLPYYVSGEIAEREQLLVQTPEALKARFNLDVRPHHEVVAIDPIEKVITVKHETEILTEHYDKLILSPGAKPFVPPITGLAEAKNVFSLRNVPDLDQIMTALTPETKRAVVIGAGFIGLEMAENLQKRGLEVTLVEKAPHVLPPLDEEMAAFVKAELSKNNVQVITGQSAVAFEEEGQVIRLEDGQTLASDLTILSVGVQPENTLAVEAGVATGLRGGIVVDEHYQTNQPDIYAVGDAIVVKQQITQEDALISLASPANRQGRQVADVIAGLERKNQGSIGTAIVRVFDLTAASTGLSERAAKAAGLTTAVVHISGKDHAGYYPGATDLQLKLVFHPTTGEIYGAQGIGAKGVDKRIDILATAIKGQLTIFDLPELEFTYAPPFGSAKDPVNMLGYAAMNLVEGLSENVQWYELSNELAKGAVLLDVRNPAFKNAVSIPLNELRERLEELDKSTEYIVSCHSGLRSYIAERMLKQAGISAKNLDGAFALYRMVKPEE 8a56 B 2.05 BS03 PAP B 1 T17 R18 R21 F70 R305 T17 R18 R21 F70 R305 ? 0000166,0016491 Q82ZQ9 36009332 601 GKIVIIGGVAGGMSAATRLRRLMEDAEIVVMEKGPFVSFANCGLPYYVSGEIAEREQLLVQTPEALKARFNLDVRPHHEVVAIDPIEKVITVKHETEILTEHYDKLILSPGAKPFVPPITGLAEAKNVFSLRNVPDLDQIMTALTPETKRAVVIGAGFIGLEMAENLQKRGLEVTLVEKAPHVLPPLDEEMAAFVKAELSKNNVQVITGQSAVAFEEEGQVIRLEDGQTLASDLTILSVGVQPENTLAVEAGVATGLRGGIVVDEHYQTNQPDIYAVGDAIVVKQQITQEDALISLASPANRQGRQVADVIAGLERKNQGSIGTAIVRVFDLTAASTGLSERAAKAAGLTTAVVHISGKDHAGYYPGATDLQLKLVFHPTTGEIYGAQGIGAKGVDKRIDILATAIKGQLTIFDLPELEFTYAPPFGSAKDPVNMLGYAAMNLVEGLSENVQWYELSNELAKGAVLLDVRNPAFKNAVSIPLNELRERLEELDKSTEYIVSCHSGLRSYIAERMLKQAGISAKNLDGAFALYRMVKPEE 8oov A 1.7 BS01 PAP A 1 K12 Y52 L55 F60 R88 T94 N115 H118 K12 Y52 L55 F60 R88 T94 N115 H118 2.7.4.6 0000287,0003723,0004536,0004550,0005515,0005524,0005525,0005634,0005737,0005769,0005829,0006183,0006228,0006241,0006259,0006897,0007399,0007595,0008285,0008408,0009117,0016020,0016301,0016310,0030154,0030879,0032587,0042802,0042981,0043024,0043388,0046872,0050679,0070062 P15531 37298313 201 MANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVESAEKEIGLWFHPEELVDYTSCAQNWIYE 8oov B 1.7 BS01 PAP B 1 K12 Y52 L55 R58 F60 T94 N115 H118 K17 Y57 L60 R63 F65 T99 N120 H123 2.7.4.6 0000287,0003723,0004536,0004550,0005515,0005524,0005525,0005634,0005737,0005769,0005829,0006183,0006228,0006241,0006259,0006897,0007399,0007595,0008285,0008408,0009117,0016020,0016301,0016310,0030154,0030879,0032587,0042802,0042981,0043024,0043388,0046872,0050679,0070062 P15531 37298313 201 PRGSHMANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVESAEKEIGLWFHPEELVDYTSCAQNWIYE 8oov C 1.7 BS01 PAP C 1 K12 Y52 L55 R58 F60 R88 T94 N115 H118 K11 Y51 L54 R57 F59 R87 T93 N114 H117 2.7.4.6 0000287,0003723,0004536,0004550,0005515,0005524,0005525,0005634,0005737,0005769,0005829,0006183,0006228,0006241,0006259,0006897,0007399,0007595,0008285,0008408,0009117,0016020,0016301,0016310,0030154,0030879,0032587,0042802,0042981,0043024,0043388,0046872,0050679,0070062 P15531 37298313 201 ANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVESAEKEIGLWFHPEELVDYTSCAQNWIYE 8vr7 B 1.9 BS04 PAP E 1 I82 R118 I84 R120 ? 0016740,0016746 Q1QD51 202 GHMILLKELKELFFLRTTYYLKKYNRSLPFGDMIVDRWDKAKLLGFGEGTSIYDSSIVLGEVKVGKDTWIGPNTILDGSGGGLIIGSNCSISAGVQIYTHDTVRKSLSGGKADIDKASTRIGSDCYLGPNTIIVKGVKIGDRVVVGANSLVLKDIPSDCKVFGSPAVIITDSLNYQR 8vr7 E 1.9 BS03 PAP E 1 Y22 R24 R35 W36 Y24 R26 R37 W38 ? 0016740,0016746 Q1QD51 202 GHMILLKELKELFFLRTTYYLKKYNRSLPFGDMIVDRWDKAKLLGFGEGTSIYDSSIVLGEVKVGKDTWIGPNTILDGSGGGLIIGSNCSISAGVQIYTHDTVRKSLSGGKADIDKASTRIGSDCYLGPNTIIVKGVKIGDRVVVGANSLVLKDIPSDCKVFGSPAVIITDSLNYQRNNI