1koj A 1.9 BS01 PAN A 1 I156 G158 S209 K210 T211 T214 G271 R272 E357 I156 G158 S209 K210 T211 T214 G271 R272 E357 K210 E216 G271 R272 E357 H388 K518 K210 E216 G271 R272 E357 H388 K518 5.3.1.9 0004347,0005125,0005576,0005615,0005737,0005829,0006094,0006096,0007165,0016853,0048029,0051156,0097367,1901135 Ki=0.2uM Ki=100nM Q9N1E2 11983887 902 AALTRNPQFQKLQQWHREHGSELNLRHLFDTDKERFNHFSLTLNTNHGHILLDYSKNLVTEEVMHMLLDLAKSRGVEAARESMFNGEKINSTEDRAVLHVALRNRSNTPIVVDGKDVMPEVNKVLDKMKAFCQRVRSGDWKGYTGKTITDVINIGIGGSDLGPLMVTEALKPYSSGGPRVWFVSNIDGTHIAKTLACLNPESSLFIIASKTFTTQETITNAKTAKDWFLLSAKDPSTVAKHFVALSTNTAKVKEFGIDPQNMFEFWDWVGGRYSLWSAIGLSIALHVGFDNFEQLLSGAHWMDQHFRTTPLEKNAPVLLAMLGIWYINCFGCETQAVLPYDQYLHRFAAYFQQGDMESNGKYITKSGARVDHQTGPIVWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIRKGLHHKILLANFLAQTEALMKGKSTEEARKELQAAGKSPEDLMKLLPHKVFEGNRPTNSIVFTKLTPFILGALIAMYEHKIFVQGVVWDINSFDQWGVELGKQLAKKIEPELDGSSPVTSHDSSTNGLINFIKQQREAKI 1koj B 1.9 BS01 PAN B 1 I156 G158 S209 K210 T211 T214 G271 R272 E357 K518 I156 G158 S209 K210 T211 T214 G271 R272 E357 K518 K210 E216 G271 R272 E357 H388 K518 K210 E216 G271 R272 E357 H388 K518 5.3.1.9 0004347,0005125,0005576,0005615,0005737,0005829,0006094,0006096,0007165,0016853,0048029,0051156,0097367,1901135 Ki=0.2uM Ki=100nM Q9N1E2 11983887 901 AALTRNPQFQKLQQWHREHGSELNLRHLFDTDKERFNHFSLTLNTNHGHILLDYSKNLVTEEVMHMLLDLAKSRGVEAARESMFNGEKINSTEDRAVLHVALRNRSNTPIVVDGKDVMPEVNKVLDKMKAFCQRVRSGDWKGYTGKTITDVINIGIGGSDLGPLMVTEALKPYSSGGPRVWFVSNIDGTHIAKTLACLNPESSLFIIASKTFTTQETITNAKTAKDWFLLSAKDPSTVAKHFVALSTNTAKVKEFGIDPQNMFEFWDWVGGRYSLWSAIGLSIALHVGFDNFEQLLSGAHWMDQHFRTTPLEKNAPVLLAMLGIWYINCFGCETQAVLPYDQYLHRFAAYFQQGDMESNGKYITKSGARVDHQTGPIVWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIRKGLHHKILLANFLAQTEALMKGKSTEEARKELQAAGKSPEDLMKLLPHKVFEGNRPTNSIVFTKLTPFILGALIAMYEHKIFVQGVVWDINSFDQWGVELGKQLAKKIEPELDGSSPVTSHDSSTNGLINFIKQQREAKI 2gc0 A 2.0 BS02 PAN A 1 Y52 T71 G87 H88 E97 Y99 H136 F148 H158 Y160 Y53 T72 G88 H89 E98 Y100 H137 F149 H159 Y161 5.3.1.9 0004347,0005506,0005737,0006094,0006096,0016853,0046872 Ki=3uM P83194 16580686 901 MMYKEPFGVKVDFETGIIEGAKKSVRRLSDMEGYFVDERAWKELVEKEDPVVYEVYAVEQEEKEGDLNFATTVLYPGKVGKEFFFTKGHFHAKLDRAEVYVALKGKGGMLLQTPEGDAKWISMEPGTVVYVPPYWAHRTVNIGDEPFIFLAIYPADAGHDYGTIAEKGFSKIVIEENGEVKVVDNPRW 2gc0 B 2.0 BS02 PAN B 1 Y52 T71 T85 G87 H88 E97 Y99 H136 F148 Y152 H158 Y160 Y53 T72 T86 G88 H89 E98 Y100 H137 F149 Y153 H159 Y161 5.3.1.9 0004347,0005506,0005737,0006094,0006096,0016853,0046872 Ki=3uM P83194 16580686 902 MMYKEPFGVKVDFETGIIEGAKKSVRRLSDMEGYFVDERAWKELVEKEDPVVYEVYAVEQEEKEGDLNFATTVLYPGKVGKEFFFTKGHFHAKLDRAEVYVALKGKGGMLLQTPEGDAKWISMEPGTVVYVPPYWAHRTVNIGDEPFIFLAIYPADAGHDYGTIAEKGFSKIVIEENGEVKVVDNPRW