1h4s A 2.85 BS03 P5A A 1 E113 R142 E144 T153 F156 W158 F205 Q225 G227 T228 H230 S258 W259 G260 S262 R264 E109 R138 E140 T149 F152 W154 F201 Q221 G223 T224 H226 S254 W255 G256 S258 R260 E113 R142 H162 E109 R138 H158 6.1.1.15 0000166,0004812,0004827,0005524,0005737,0006412,0006418,0006433,0017101,0046872 Q5SM28 11399074 1478 KGLTPQSQDFSEWYLEVIQKAELADYGPVRGTIVVRPYGYAIWENIQQVLDRMFKETGHQNAYFPLFIPMSFLRKEAEHVEGFSPELAVVTHAGGEELEEPLAVRPTSETVIGYMWSKWIRSWRDLPQLLNQWGNVVRWEMRTRPFLRTSEFLWQEGHTAHATREEAEEEVRRMLSIYARLAREYAAIPVIEGLKTEKEKFAGAVYTTTIEALMKDGKALQAGTSHYLGENFARAFDIKFQDRDLQVKYVHTTSWGLSWRFIGAIIMTHGDDRGLVLPPRLAPIQVVIVPIYKDESRERVLEAAQGLRQALLAQGLRVHLDDRDQHTPGYKFHEWELKGVPFRVELGPKDLEGGQAVLASRLGGKETLPLAALPEALPGKLDAFHEELYRRALAFREDHTRKVDTYEAFKEAVQEGFALAFHCGDKACERLIQEETTATTRCVPFEAEPEEGFCVRCGRPSAYGKRVVFAKAY 1h4s B 2.85 BS03 P5A B 1 T111 E113 R142 E144 L151 R152 T153 F156 W158 E160 F205 Q225 G227 T228 H230 S258 W259 G260 S262 R264 T107 E109 R138 E140 L147 R148 T149 F152 W154 E156 F201 Q221 G223 T224 H226 S254 W255 G256 S258 R260 E113 R142 H162 E109 R138 H158 6.1.1.15 0000166,0004812,0004827,0005524,0005737,0006412,0006418,0006433,0017101,0046872 Q5SM28 11399074 1478 KGLTPQSQDFSEWYLEVIQKAELADYGPVRGTIVVRPYGYAIWENIQQVLDRMFKETGHQNAYFPLFIPMSFLRKEAEHVEGFSPELAVVTHAGGEELEEPLAVRPTSETVIGYMWSKWIRSWRDLPQLLNQWGNVVRWEMRTRPFLRTSEFLWQEGHTAHATREEAEEEVRRMLSIYARLAREYAAIPVIEGLKTEKEKFAGAVYTTTIEALMKDGKALQAGTSHYLGENFARAFDIKFQDRDLQVKYVHTTSWGLSWRFIGAIIMTHGDDRGLVLPPRLAPIQVVIVPIYKDESRERVLEAAQGLRQALLAQGLRVHLDDRDQHTPGYKFHEWELKGVPFRVELGPKDLEGGQAVLASRLGGKETLPLAALPEALPGKLDAFHEELYRRALAFREDHTRKVDTYEAFKEAVQEGFALAFHCGDKACERLIQEETTATTRCVPFEAEPEEGFCVRCGRPSAYGKRVVFAKAY 1nj5 A 2.8 BS03 P5A A 1 T117 E119 R148 I158 V160 I163 F166 E168 F212 Q232 T235 H237 C265 Y266 G267 S269 R271 T99 E101 R130 I140 V142 I145 F148 E150 F194 Q214 T217 H219 C247 Y248 G249 S251 R253 E119 R148 H170 E101 R130 H152 6.1.1.15 0000166,0004812,0004827,0005515,0005524,0005737,0006412,0006418,0006433,0017101,0046872 -logKd/Ki=7.30, Ki=50nM O26708 12578991 510 EFSEWFHNILEEAEIIDQRYPVKGMHVWMPHGFMIRKNTLKILRRILDRDHEEVLFPLLVPEDELAKEAIHVKGFEDEVYWVTHGGLSKLQRKLALRPTSETVMYPMFALWVRSHTDLPMRFYQVVNTFRYETKHTRPLIRVREITTFKEAHTIHATASEAEEQVERAVEIYKEFFNSLGIPYLITRRPPWDKFPGSEYTVAFDTLMPDGKTLQIGTVHNLGQTFARTFEIKFETPEGDHEYVHQTCYGLSDRVIASVIAIHGDESGLCLPPDVAAHQVVIVPIIFKKAAEEVMEACRELRSRLEAAGFRVHLDDRDIRAGRKYYEWEMRGVPLRVEIGPRDLEKGAAVISRRDTGEKVTADLQGIEETLRELMKDILENLRTRAWERMESEIREAETLEEASRIVDEKRGIISFMWCGEEECGMDVEEKVRVDILGIQEEGSGTCINCGREAPYRAYLARTY 2i4m B 2.8 BS01 P5A B 1 T109 E111 R140 F155 M157 D159 Y161 I202 E282 V283 G284 Q285 F287 Y316 G317 G319 R322 T112 E114 R143 F158 M160 D162 Y164 I205 E285 V286 G287 Q288 F290 Y319 G320 G322 R325 E111 R140 M157 D159 Y161 I246 H312 E114 R143 M160 D162 Y164 I249 H315 6.1.1.15 0000166,0004812,0004827,0005524,0005737,0005829,0006412,0006418,0006433 Q6N5P6 17027500 439 GSHMRLSRFFLPILKENPKEAEIVSHRLMLRAGMLRQEAAGIYAWLPLGHRVLKKIEQIVREEQNRAGAIELLMPTLQLADLWRESGRYDAYGPEMLRIADRHKRELLYGPTNEEMITEIFRAYIKSYKSLPLNLYHIQWKFRDEQRPRFGVMRGREFLMKDAYSFDVDEAGARKSYNKMFVAYLRTFARMGLKAIPMRAETGPIGGDLSHEFIVLAETGESGVYIDRDVLNLPVPDENVDYDGDLTPIIKQWTSVYAATEDVHEPARYESEVPEANRLNTRGIEVGQIFYFGTKYSDSMKANVTGPDGTDAPIHGGSYGVGVSRLLGAIIEACHDDNGIIWPEAVAPFRVTILNLKQGDAATDAACDQLYRELSAKGVDVLYDDTDQRAGAKFATADLIGIPWQIHVGPRGLAEGKVELKRRSDGARENLALADVVARLT 2i4m C 2.8 BS01 P5A C 1 E111 R140 F155 M157 D159 Y161 E282 V283 G284 Q285 S315 Y316 G317 G319 R322 E114 R143 F158 M160 D162 Y164 E285 V286 G287 Q288 S318 Y319 G320 G322 R325 E111 R140 M157 D159 Y161 I246 H312 E114 R143 M160 D162 Y164 I249 H315 6.1.1.15 0000166,0004812,0004827,0005524,0005737,0005829,0006412,0006418,0006433 Q6N5P6 17027500 439 GSHMRLSRFFLPILKENPKEAEIVSHRLMLRAGMLRQEAAGIYAWLPLGHRVLKKIEQIVREEQNRAGAIELLMPTLQLADLWRESGRYDAYGPEMLRIADRHKRELLYGPTNEEMITEIFRAYIKSYKSLPLNLYHIQWKFRDEQRPRFGVMRGREFLMKDAYSFDVDEAGARKSYNKMFVAYLRTFARMGLKAIPMRAETGPIGGDLSHEFIVLAETGESGVYIDRDVLNLPVPDENVDYDGDLTPIIKQWTSVYAATEDVHEPARYESEVPEANRLNTRGIEVGQIFYFGTKYSDSMKANVTGPDGTDAPIHGGSYGVGVSRLLGAIIEACHDDNGIIWPEAVAPFRVTILNLKQGDAATDAACDQLYRELSAKGVDVLYDDTDQRAGAKFATADLIGIPWQIHVGPRGLAEGKVELKRRSDGARENLALADVVARLT 2j3l A 2.3 BS01 P5A A 1 T109 E111 R140 E142 G152 F155 M157 D159 Y161 M202 E407 H410 F412 C440 Y441 G442 G444 R447 T109 E111 R140 E142 G152 F155 M157 D159 Y161 M202 E407 H410 F412 C440 Y441 G442 G444 R447 E111 R140 M157 D159 Y161 V336 I437 E111 R140 M157 D159 Y161 V336 I437 6.1.1.15 0000166,0002161,0004812,0004827,0005524,0005737,0005829,0006412,0006418,0006433,0016740,0106074 Q831W7 17027500 1576 MKQSKMLIPTLREVPNDAEVLSHQILLRAGYIRQVAAGIYSYLPLANRVLEKLKTIMREEFEKIDAVEMLMPALLPAELWKESGRYETYGPNLYRLKDRNDRDYILGPTHEETFTELIRDEINSYKRLPLNLYQIQTKYRDEKRSRSGLLRGREFIMKDGYSFHADEASLDQSYRDYEKAYSRIFERCGLEFRAIIGDGGAMGGKDSKEFMAISEIGEDTICYSTESDYAANLEMATSLYTPKKSHETQLDLEKIATPEVGTIAEVANFFEVEPQRIIKSVLFIADEEPVMVLVRGDHDVNDVKLKNFLGADFLDEATEEDARRVLGAGFGSIGPVNVSEDVKIYADLAVQDLANAIVGANEDGYHLTNVNPDRDFQPISYEDLRFVQEGDPSPDGNGVLAFTKGIEIGHIFKLGTRYSDAMGATVLDENGREKSVIMGCYGIGVSRLLSAIVEQNADERGINWPTGIAPFDLHVVQMNVKDEYQTKLSQEVEAMMTEAGYEVLVDDRNERAGVKFADADLIGCPIRITVGKKAVDGVVEVKIKRTGEMLEVRKEELESTLSILM 2j3l B 2.3 BS01 P5A B 1 T109 E111 R140 E142 G152 F155 M157 D159 Y161 M202 E407 I408 G409 H410 F412 Y441 G442 G444 R447 T109 E111 R140 E142 G152 F155 M157 D159 Y161 M202 E407 I408 G409 H410 F412 Y441 G442 G444 R447 E111 R140 M157 D159 Y161 V336 I437 E111 R140 M157 D159 Y161 V336 I437 6.1.1.15 0000166,0002161,0004812,0004827,0005524,0005737,0005829,0006412,0006418,0006433,0016740,0106074 Q831W7 17027500 1582 MKQSKMLIPTLREVPNDAEVLSHQILLRAGYIRQVAAGIYSYLPLANRVLEKLKTIMREEFEKIDAVEMLMPALLPAELWKESGRYETYGPNLYRLKDRNDRDYILGPTHEETFTELIRDEINSYKRLPLNLYQIQTKYRDEKRSRSGLLRGREFIMKDGYSFHADEASLDQSYRDYEKAYSRIFERCGLEFRAIIGDGGAMGGKDSKEFMAISEIGEDTICYSTESDYAANLEMATSLYTPKKSHETQLDLEKIATPEVGTIAEVANFFEVEPQRIIKSVLFIADEEPVMVLVRGDHDVNDVKLKNFLGADFLDEATEEDARRVLGAGFGSIGPVNVSEDVKIYADLAVQDLANAIVGANEDGYHLTNVNPDRDFQPISYEDLRFVQEGDPSPDGNGVLAFTKGIEIGHIFKLGTRYSDAMGATVLDENGREKSVIMGCYGIGVSRLLSAIVEQNADERGINWPTGIAPFDLHVVQMNVKDEYQTKLSQEVEAMMTEAGYEVLVDDRNERAGVKFADADLIGCPIRITVGKKAVDGVVEVKIKRTGEMLEVRKEELESTLSILMNTTSE