2wih A 2.5 BS01 P48 A 1 I10 Y15 V18 A31 K33 F80 L83 H84 L134 D145 I14 Y19 V22 A35 K37 F84 L87 H88 L138 D149 D127 K129 Q131 N132 D145 T158 T165 D131 K133 Q135 N136 D149 T162 T169 2.7.11.22 0000082,0000086,0000122,0000287,0000307,0000781,0000793,0000805,0000806,0001673,0004672,0004674,0004693,0005515,0005524,0005634,0005635,0005654,0005667,0005737,0005768,0005813,0005829,0005856,0006260,0006281,0006338,0006351,0006468,0006813,0007099,0007165,0007265,0007346,0008284,0010389,0010468,0015030,0016301,0016310,0018105,0019904,0030332,0031453,0031571,0032298,0035173,0043247,0043687,0045740,0045893,0046872,0051298,0051301,0051321,0071732,0090398,0097123,0097124,0097134,0097135,0097472,0106310,1905784 ic50=0.045uM -logKd/Ki=7.35, IC50=45nM IC50=45nM P24941 19603809 1299 PLVDMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 2wih C 2.5 BS01 P48 C 1 I10 Y15 V18 A31 K33 F80 L83 H84 D86 K89 L134 D145 I11 Y16 V19 A32 K34 F81 L84 H85 D87 K90 L135 D146 D127 K129 Q131 N132 D145 T158 T165 D128 K130 Q132 N133 D146 T159 T166 2.7.11.22 0000082,0000086,0000122,0000287,0000307,0000781,0000793,0000805,0000806,0001673,0004672,0004674,0004693,0005515,0005524,0005634,0005635,0005654,0005667,0005737,0005768,0005813,0005829,0005856,0006260,0006281,0006338,0006351,0006468,0006813,0007099,0007165,0007265,0007346,0008284,0010389,0010468,0015030,0016301,0016310,0018105,0019904,0030332,0031453,0031571,0032298,0035173,0043247,0043687,0045740,0045893,0046872,0051298,0051301,0051321,0071732,0090398,0097123,0097124,0097134,0097135,0097472,0106310,1905784 ic50=0.045uM IC50=45nM P24941 19603809 1299 DMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 5vc6 A 2.0 BS01 P48 A 1 I305 F310 V313 A326 K328 N376 C379 G382 F433 D463 I13 F18 V21 A34 K36 N84 C87 G90 F141 D151 D426 K428 D134 K136 2.7.10.2 0004672,0005524,0006468 Kd=13.6nM -logKd/Ki=7.87, Kd=13.6nM Kd=14nM P30291 28792760 601 SRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRVMFKIGDLGHVTRISSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLS 5vd1 A 1.7 BS01 P48 A 1 L116 Y121 V124 A137 K139 C190 G191 P192 Q196 F240 D251 L50 Y55 V58 A71 K73 C124 G125 P126 Q130 F174 D185 D233 K235 N238 D251 D270 D167 K169 N172 D185 D204 2.7.11.1 0004672,0005524,0006468 Kd=990nM -logKd/Ki=6.00, Kd=990nM Kd=990nM Q99640 28792760 401 LGTENLYFQSLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQ