2xkw A 2.02 BS01 P1B A 1 F282 C285 Q286 S289 H323 I341 M364 H449 Y473 F66 C69 Q70 S73 H107 I125 M148 H233 Y257 ? 0003677,0004879,0005634,0006355 EC50=250nM, IC50=1700nM, Kd=871nM, Ki=420nM P37231 1478 LNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 2xkw B 2.02 BS01 P1B B 1 L255 E259 F264 H266 R280 R288 L330 I341 L49 E53 F58 H60 R67 R75 L117 I128 ? 0003677,0004879,0005634,0006355 EC50=250nM, IC50=1700nM, Kd=871nM, Ki=420nM P37231 1475 ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTEHPLLQEIYK 4a79 A 1.89 BS02 P1B A 1 Y60 F103 P104 W119 L171 I198 I199 Q206 I316 Y326 F343 Y58 F101 P102 W117 L169 I196 I197 Q204 I314 Y324 F341 G62 R197 K296 G60 R195 K294 1.4.3.21,1.4.3.4 0005515,0005739,0005740,0005741,0008131,0009055,0009410,0009636,0010044,0010269,0014063,0016491,0019607,0021762,0030425,0032496,0042420,0042802,0043025,0045471,0045964,0048545,0050660,0050665,0051412,0052595,0097621 Ki=0.5uM P27338 22282722 601 NKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTI 4a79 B 1.89 BS02 P1B B 1 Y60 F103 W119 L171 I198 I199 Q206 I316 Y326 F343 Y398 Y58 F101 W117 L169 I196 I197 Q204 I314 Y324 F341 Y396 G62 R197 K296 G60 R195 K294 1.4.3.21,1.4.3.4 0005515,0005739,0005740,0005741,0008131,0009055,0009410,0009636,0010044,0010269,0014063,0016491,0019607,0021762,0030425,0032496,0042420,0042802,0043025,0045471,0045964,0048545,0050660,0050665,0051412,0052595,0097621 Ki=0.5uM P27338 22282722 601 NKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLI 7m26 A 1.3 BS02 P1B A 1 H94 H96 H119 F131 L198 T199 T200 P202 W209 H92 H94 H117 F128 L195 T196 T197 P199 W206 4.2.1.1,4.2.1.69 0002009,0004064,0004089,0005515,0005737,0005829,0005886,0006730,0008270,0015670,0016829,0018820,0032230,0032849,0038166,0043209,0044070,0045177,0046872,0046903,0051453,0070050,0070062,2001150,2001225 P00918 34070212 302 HHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK