1c88 A 1.8 BS01 OTA A 1 Y46 D48 K120 D181 F182 C215 S216 A217 I219 G220 R221 Q262 Y45 D47 K119 D180 F181 C214 S215 A216 I218 G219 R220 Q261 D181 C215 R221 S222 Q262 D180 C214 R220 S221 Q261 3.1.3.48 0004725,0006470,0016311 Ki=5.1uM -logKd/Ki=5.29, Ki=5.1uM IC50=500000nM, Ki=11500nM P18031 10744717 301 EMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKTYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLDMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHED 5k9w A 2.01 BS01 OTA A 1 Y46 D48 K120 D181 F182 C215 S216 A217 I219 G220 R221 Y47 D49 K121 D182 F183 C216 S217 A218 I220 G221 R222 D181 C215 R221 S222 Q262 D182 C216 R222 S223 Q263 3.1.3.48 0004725,0006470,0016311 Kd=26uM -logKd/Ki=4.59, Kd=26uM IC50=500000nM, Ki=11500nM P18031 28212750 402 SMEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHE 5ka1 A 1.84 BS01 OTA A 1 Y46 D48 K120 D181 F182 C215 S216 A217 I219 G220 R221 Y48 D50 K122 D183 F184 C217 S218 A219 I221 G222 R223 D181 C215 R221 S222 Q262 D183 C217 R223 S224 Q264 3.1.3.48 0004725,0006470,0016311 Kd=33uM -logKd/Ki=4.48, Kd=33uM IC50=500000nM, Ki=11500nM P18031 28212750 301 ASMEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIM 5ka3 A 2.141 BS01 OTA A 1 Y46 D48 K120 D181 F182 C215 S216 A217 I219 G220 R221 Y45 D47 K119 D180 F181 C214 S215 A216 I218 G219 R220 D181 C215 R221 S222 Q262 D180 C214 R220 S221 Q261 3.1.3.48 0004725,0006470,0016311 Kd=26uM -logKd/Ki=4.59, Kd=26uM IC50=500000nM, Ki=11500nM P18031 28212750 401 EMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSAATVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSH 5ka7 A 2.061 BS01 OTA A 1 Y46 D48 K120 D181 F182 C215 S216 A217 I219 G220 R221 Q262 Y47 D49 K121 D182 F183 C216 S217 A218 I220 G221 R222 Q263 D181 C215 R221 S222 Q262 D182 C216 R222 S223 Q263 3.1.3.48 0004725,0006470,0016311 Kd=45uM -logKd/Ki=4.35, Kd=45uM IC50=500000nM, Ki=11500nM P18031 28212750 303 SMEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTAWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHE 5ka9 A 2.07 BS01 OTA A 1 Y46 D48 K120 C215 S216 A217 I219 G220 R221 Y51 D53 K125 C220 S221 A222 I224 G225 R226 D181 C215 R221 S222 Q262 D186 C220 R226 S227 Q267 3.1.3.48 0004725,0006470,0016311 Kd=39uM -logKd/Ki=4.41, Kd=39uM IC50=500000nM, Ki=11500nM P18031 28212750 307 GHMASMEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFANFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKEL 5kab A 1.968 BS01 OTA A 1 Y46 D48 K120 C215 S216 A217 I219 G220 R221 Q262 Y46 D48 K120 C215 S216 A217 I219 G220 R221 Q262 D181 C215 R221 S222 Q262 D181 C215 R221 S222 Q262 3.1.3.48 0004725,0006470,0016311 -logKd/Ki=4.68, Kd=21uM IC50=500000nM, Ki=11500nM P18031 28212750 306 MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVGESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIM 5kad A 1.9 BS01 OTA A 1 Y46 D48 K120 D181 F182 C215 S216 A217 I219 G220 R221 Q262 Y50 D52 K124 D185 F186 C219 S220 A221 I223 G224 R225 Q266 D181 C215 R221 S222 Q262 D185 C219 R225 S226 Q266 3.1.3.48 0004725,0006470,0016311 Kd=37uM -logKd/Ki=4.43, Kd=37uM IC50=500000nM, Ki=11500nM P18031 28212750 401 HMASMEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLAFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFI 5kad B 1.9 BS01 OTA B 1 Y46 D48 K120 D181 F182 C215 S216 A217 I219 G220 R221 Y49 D51 K123 D184 F185 C218 S219 A220 I222 G223 R224 D181 C215 R221 S222 Q262 D184 C218 R224 S225 Q262 3.1.3.48 0004725,0006470,0016311 Kd=37uM IC50=500000nM, Ki=11500nM P18031 28212750 401 MASMEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLAFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIM 7mm1 A 1.85 BS01 OTA A 1 Y46 D48 K120 D181 F182 C215 S216 A217 I219 G220 R221 Y46 D48 K120 D181 F182 C215 S216 A217 I219 G220 R221 3.1.3.48 0004725,0006470,0016311 IC50=500000nM, Ki=11500nM P18031 35916223 401 MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPSRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTVGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHED 7mn7 A 1.95 BS01 OTA A 1 Y46 D48 K120 D181 F182 C215 S216 A217 I219 G220 R221 Q262 Y47 D49 K121 D182 F183 C216 S217 A218 I220 G221 R222 Q263 3.1.3.48 0004725,0006470,0016311 P18031 35921420 409 SMEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTYCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDL 7mna A 1.47 BS01 OTA A 1 Y46 D48 K120 D181 F182 C215 S216 A217 I219 G220 R221 Q262 Y45 D47 K119 D180 F181 C214 S215 A216 I218 G219 R220 Q261 3.1.3.48 0004725,0006470,0016311 P18031 35921420 301 EMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVNESGSLSPEHGPVVVHCSAGIGRSGTYCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKF 7mnb A 2.2 BS01 OTA A 1 Y46 D48 K120 D181 F182 C215 S216 A217 I219 G220 R221 Y46 D48 K120 D181 F182 C215 S216 A217 I219 G220 R221 3.1.3.48 0004725,0006470,0016311 P18031 35921420 401 MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFRFKVNESGSLSPEHGPVVVHCSAGIGRSGTYCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHED 7mnd A 2.29 BS01 OTA A 1 Y46 D48 K120 D181 F182 C215 S216 A217 I219 G220 R221 Q262 Y47 D49 K121 D182 F183 C216 S217 A218 I220 G221 R222 Q263 3.1.3.48 0004725,0006470,0016311 P18031 35921420 402 SMEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSASPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHED 7mnf A 1.7 BS01 OTA A 1 Y46 D48 K120 C215 S216 A217 I219 R221 Q262 Y45 D47 K119 C214 S215 A216 I218 R220 Q261 3.1.3.48 0004725,0006470,0016311 P18031 35921420 401 EMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSGEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKF 7mow A 1.8 BS01 OTA A 1 Y46 D48 K120 D181 F182 C215 S216 A217 I219 G220 R221 Q262 Y48 D50 K122 D183 F184 C217 S218 A219 I221 G222 R223 Q264 3.1.3.48 0004725,0006470,0016311 P18031 35921420 401 ASMEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTICLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHED