6pm9 A 2.86 BS01 OQ1 A 1 G67 Y69 K98 D174 D175 Y219 T250 V254 W278 N280 D285 N313 G9 Y11 K40 D116 D117 Y161 T192 V196 W220 N222 D227 N255 3.2.1.169 -logKd/Ki=8.10, Ki=7.9nM Ki=5.70nM, EC50=53nM, IC50=7.9nM O60502 31487175 501 RFLCGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYKHRMFWREMYSVEEAEQLMTLISAAREYEIEFIYAISPGLDITFSNPKEVSTLKRKLDQVSQFGCRSFALLFDDIDHNMCAADKEVFSSFAHAQVSITNEIYQYLGEPETFLFCPTEYCGTFCYPNVSQSPYLRTVGEKLLPGIEVLWTGPKVVSKEIPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYKGRSTELIPRLKGVLTNPNCEFEANYVAIHTLATWYKSNMNGVRDVLYSPQMALKLALTEWLQEFGVPHQY 6pm9 B 2.86 BS01 OQ1 B 1 G67 Y69 K98 D174 D175 Y219 T250 V254 W278 N280 D285 G9 Y11 K40 D116 D117 Y161 T192 V196 W220 N222 D227 3.2.1.169 Ki=5.70nM, EC50=53nM, IC50=7.9nM O60502 31487175 501 RFLCGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYKHRMFWREMYSVEEAEQLMTLISAAREYEIEFIYAISPGLDITFSNPKEVSTLKRKLDQVSQFGCRSFALLFDDIDHNMCAADKEVFSSFAHAQVSITNEIYQYLGEPETFLFCPTEYCGTFCYPNVSQSPYLRTVGEKLLPGIEVLWTGPKVVSKEIPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYKGRSTELIPRLKGVLTNPNCEFEANYVAIHTLATWYKSNMNGVRDVLYSPQMALKLALTEWLQEFGVPHQY 6pm9 C 2.86 BS01 OQ1 C 1 G67 Y69 K98 D174 Y219 T250 V254 W278 N280 D285 Y286 N313 G19 Y21 K50 D126 Y166 T197 V201 W225 N227 D232 Y233 N260 3.2.1.169 Ki=5.70nM, EC50=53nM, IC50=7.9nM O60502 31487175 501 AVAGAAGGARRFLCGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYKHRMFWREMYSVEEAEQLMTLISAAREYEIEFIYAISPGLDITFSNPKEVSTLKRKLDQVSQFGCRSFALLFDMCAADKEVFSSFAHAQVSITNEIYQYLGEPETFLFCPTEYCGTFCYPNVSQSPYLRTVGEKLLPGIEVLWTGPKVVSKEIPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYKGRSTELIPRLKGVLTNPNCEFEANYVAIHTLATWYKSNMNGVRTDVLYSPQMALKLALTEWLQEFG 6pm9 D 2.86 BS01 OQ1 D 1 G67 K98 D174 C215 Y219 T250 V254 W278 N280 D285 G18 K49 D125 C162 Y166 T197 V201 W225 N227 D232 3.2.1.169 Ki=5.70nM, EC50=53nM, IC50=7.9nM O60502 31487175 501 VAGAAGGARRFLCGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYKHRMFWREMYSVEEAEQLMTLISAAREYEIEFIYAISPGLDITFSNPKEVSTLKRKLDQVSQFGCRSFALLFDNMCAADKEVFSSFAHAQVSITNEIYQYLGEPETFLFCPTEYCGTFCYPNVSQSPYLRTVGEKLLPGIEVLWTGPKVVSKEIPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYKGRSTELIPRLKGVLTNPNCEFEANYVAIHTLATWYKSNMNGVRTDVLYSPQMALKLALTEWLQEFG