1kvo A 2.0 BS03 OAP A 1 F5 A17 A18 G22 G29 V30 C44 H47 D48 Y51 F5 A17 A18 G22 G29 V30 C44 H47 D48 Y51 H27 G29 G31 H47 D48 Y51 Y66 D91 H27 G29 G31 H47 D48 Y51 Y66 D91 3.1.1.4 0004623,0005509,0005543,0005576,0005615,0005739,0005741,0005783,0005789,0005886,0006629,0006644,0006954,0010744,0016042,0016787,0030141,0031640,0034374,0036335,0042130,0042742,0046337,0046470,0046473,0046872,0047498,0048471,0050482,0050729,0050830,0070062,0070374,1902563 ic50=0.013uM -logKd/Ki=7.89, IC50=0.013uM IC50=21nM P14555 8831753 190 NLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC 1kvo B 2.0 BS03 OAP B 1 L2 F5 A17 A18 Y21 G29 V30 G31 C44 H47 D48 Y51 L2 F5 A17 A18 Y21 G29 V30 G31 C44 H47 D48 Y51 H27 G29 G31 H47 D48 Y51 Y66 D91 H27 G29 G31 H47 D48 Y51 Y66 D91 3.1.1.4 0004623,0005509,0005543,0005576,0005615,0005739,0005741,0005783,0005789,0005886,0006629,0006644,0006954,0010744,0016042,0016787,0030141,0031640,0034374,0036335,0042130,0042742,0046337,0046470,0046473,0046872,0047498,0048471,0050482,0050729,0050830,0070062,0070374,1902563 ic50=0.013uM IC50=21nM P14555 8831753 190 NLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC 1kvo C 2.0 BS03 OAP C 1 L2 F5 A17 Y21 G29 V30 G31 C44 H47 D48 Y51 L2 F5 A17 Y21 G29 V30 G31 C44 H47 D48 Y51 H27 G29 G31 H47 D48 Y51 Y66 D91 H27 G29 G31 H47 D48 Y51 Y66 D91 3.1.1.4 0004623,0005509,0005543,0005576,0005615,0005739,0005741,0005783,0005789,0005886,0006629,0006644,0006954,0010744,0016042,0016787,0030141,0031640,0034374,0036335,0042130,0042742,0046337,0046470,0046473,0046872,0047498,0048471,0050482,0050729,0050830,0070062,0070374,1902563 ic50=0.013uM IC50=21nM P14555 8831753 190 NLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC 1kvo D 2.0 BS03 OAP D 1 L2 G22 F23 G29 V30 G31 C44 H47 D48 Y51 L2 G22 F23 G29 V30 G31 C44 H47 D48 Y51 H27 G29 G31 H47 D48 Y51 Y66 D91 H27 G29 G31 H47 D48 Y51 Y66 D91 3.1.1.4 0004623,0005509,0005543,0005576,0005615,0005739,0005741,0005783,0005789,0005886,0006629,0006644,0006954,0010744,0016042,0016787,0030141,0031640,0034374,0036335,0042130,0042742,0046337,0046470,0046473,0046872,0047498,0048471,0050482,0050729,0050830,0070062,0070374,1902563 ic50=0.013uM IC50=21nM P14555 8831753 190 NLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC 1kvo E 2.0 BS03 OAP E 1 L2 H6 A17 A18 G29 V30 G31 C44 H47 D48 Y51 L2 H6 A17 A18 G29 V30 G31 C44 H47 D48 Y51 H27 G29 G31 H47 D48 Y51 Y66 D91 H27 G29 G31 H47 D48 Y51 Y66 D91 3.1.1.4 0004623,0005509,0005543,0005576,0005615,0005739,0005741,0005783,0005789,0005886,0006629,0006644,0006954,0010744,0016042,0016787,0030141,0031640,0034374,0036335,0042130,0042742,0046337,0046470,0046473,0046872,0047498,0048471,0050482,0050729,0050830,0070062,0070374,1902563 ic50=0.013uM IC50=21nM P14555 8831753 190 NLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC 1kvo F 2.0 BS03 OAP F 1 L2 F5 A17 Y21 G22 F23 G29 V30 G31 H47 D48 Y51 L2 F5 A17 Y21 G22 F23 G29 V30 G31 H47 D48 Y51 H27 G29 G31 H47 D48 Y51 Y66 D91 H27 G29 G31 H47 D48 Y51 Y66 D91 3.1.1.4 0004623,0005509,0005543,0005576,0005615,0005739,0005741,0005783,0005789,0005886,0006629,0006644,0006954,0010744,0016042,0016787,0030141,0031640,0034374,0036335,0042130,0042742,0046337,0046470,0046473,0046872,0047498,0048471,0050482,0050729,0050830,0070062,0070374,1902563 ic50=0.013uM IC50=21nM P14555 8831753 190 NLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC