2qyk A 2.1 BS01 NPV A 1 Y371 H372 N533 I548 F552 M569 S580 Q581 F584 Y83 H84 N245 I260 F264 M281 S292 Q293 F296 3.1.4.53 0004114,0007165,0008081 ic50=3.3uM -logKd/Ki=5.48, IC50=3.3uM IC50=3300nM, EC50=20nM P27815 17727341 3 MNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAI 2qyk B 2.1 BS01 NPV B 1 Y371 M485 N533 I548 F552 M569 S580 Q581 F584 Y84 M198 N246 I261 F265 M282 S293 Q294 F297 3.1.4.53 0004114,0007165,0008081 ic50=3.3uM IC50=3300nM, EC50=20nM P27815 17727341 3 HMNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAI 2qyl A 1.95 BS03 NPV A 1 Y233 M347 N395 I410 F414 Q443 F446 Y83 M197 N245 I260 F264 Q293 F296 3.1.4.53 0004114,0007165,0008081 ic50=0.65uM -logKd/Ki=6.19, IC50=0.65uM IC50=650nM Q07343 17727341 1 MSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIP 2qyn A 1.57 BS01 NPV A 1 Y159 M273 N321 I336 F340 M357 Q369 F372 Y74 M188 N236 I251 F255 M272 Q284 F287 3.1.4.53 0004114,0007165,0008081 ic50=0.57uM -logKd/Ki=6.24, IC50=0.57uM IC50=1nM Q08499 17727341 1 TEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIP 2qyn B 1.57 BS01 NPV B 1 Y159 H160 M273 N321 I336 F340 M357 Q369 F372 Y72 H73 M186 N234 I249 F253 M270 Q282 F285 3.1.4.53 0004114,0007165,0008081 ic50=0.57uM IC50=1nM Q08499 17727341 1 QEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQ