1c2t A 2.1 BS01 NHS A 1 R64 R90 I91 L92 N106 H108 L118 V139 T140 L143 D144 R64 R90 I91 L92 N106 H108 L118 V139 T140 L143 D144 N106 H108 S135 D144 N106 H108 S135 D144 2.1.2.2 0003824,0004644,0005737,0005829,0006164,0006189,0006974,0009058,0016740 Ki=260nM P08179 10606510 222 MNIVVLISGNGSNLQAIIDACKTNKIKGTVRAVFSNKADAFGLERARQAGIATHTLIASAFDSREAYDRELIHEIDMYAPDVVVLAGFMRILSPAFVSHYAGRLLNIHPSLLPKYPGLHTHRQALENGDEEHGTSVHFVTDELDGGPVILQAKVPVFAGDSEDDITARVQTQEHAIYPLVISWFADGRLKMHENAAWLDGQRLPPQGYA 1c2t B 2.1 BS01 NHS B 1 R64 F88 M89 R90 I91 L92 N106 H108 L118 V139 T140 D141 L143 D144 R64 F88 M89 R90 I91 L92 N106 H108 L118 V139 T140 D141 L143 D144 N106 H108 S135 D144 N106 H108 S135 D144 2.1.2.2 0003824,0004644,0005737,0005829,0006164,0006189,0006974,0009058,0016740 Ki=260nM -logKd/Ki=6.59, Ki=260nM P08179 10606510 220 MNIVVLISGNGSNLQAIIDACKTNKIKGTVRAVFSNKADAFGLERARQAGIATHTLIASAFDSREAYDRELIHEIDMYAPDVVVLAGFMRILSPAFVSHYAGRLLNIHPSLLPKYPGLHTHRQALENGDEEHGTSVHFVTDELDGGPVILQAKVPVFAGDSEDDITARVQTQEHAIYPLVISWFADGRLKMHENAAWLDGQRLPPQGYA