1qwj A 2.8 BS01 NCC A 1 L48 R50 N60 R109 S118 S120 Q141 G213 Y216 L9 R11 N21 R70 S79 S81 Q102 G174 Y177 2.7.7.43 Q99KK2 14636592 2002 PPHLAALVLARGGSKGIPLKNIKRLAGVPLIGWVLRAALDAGVFQSVWVSTDHDEIENVAKQFGAQVHRRSSETSKDSSTSLDAIVEFLNYHNEVDIVGNIQATSPCLHPTDLQKVAEMIREEGYDSVFSVVRRHQFRWSEIQKGVREVTEPLNLNPAKRPRRQDWDGELYENGSFYFAKRHLIEMGYLQGGKMAYYEMRAEHSVDIDVDIDWPIAEQRVLRFGYFGK 1qwj B 2.8 BS01 NCC A 1 R199 R201 R202 R160 R162 R163 2.7.7.43 Q99KK2 14636592 2002 PPHLAALVLARGGSKGIPLKNIKRLAGVPLIGWVLRAALDAGVFQSVWVSTDHDEIENVAKQFGAQVHRRSSETSKDSSTSLDAIVEFLNYHNEVDIVGNIQATSPCLHPTDLQKVAEMIREEGYDSVFSVVRRHQFRWSEIQKGVREVTEPLNLNPAKRPRRQDWDGELYENGSFYFAKRHLIEMGYLQGGKMAYYEMRAEHSVDIDVDIDWPIAEQRVLRFGYFGKE 1qwj C 2.8 BS01 NCC C 1 L48 A49 R50 K59 N60 R109 S118 Q141 T143 G213 Y216 L9 A10 R11 K20 N21 R70 S79 Q102 T104 G174 Y177 2.7.7.43 Q99KK2 14636592 3002 PPHLAALVLARGGSKGIPLKNIKRLAGVPLIGWVLRAALDAGVFQSVWVSTDHDEIENVAKQFGAQVHRRSSETSKDSSTSLDAIVEFLNYHNEVDIVGNIQATSPCLHPTDLQKVAEMIREEGYDSVFSVVRRHQFRWSEIQKGVREVTEPLNLNPAKRPRRQDWDGELYENGSFYFAKRHLIEMGYLQGGKMAYYEMRAEHSVDIDVDIDWPIAEQRVLRFGYFGK 1qwj D 2.8 BS01 NCC C 1 R199 R201 R160 R162 2.7.7.43 Q99KK2 14636592 3002 PPHLAALVLARGGSKGIPLKNIKRLAGVPLIGWVLRAALDAGVFQSVWVSTDHDEIENVAKQFGAQVHRRSSETSKDSSTSLDAIVEFLNYHNEVDIVGNIQATSPCLHPTDLQKVAEMIREEGYDSVFSVVRRHQFRWSEIQKGVREVTEPLNLNPAKRPRRQDWDGELYENGSFYFAKRHLIEMGYLQGGKMAYYEMRAEHSVDIDVDIDWPIAEQRVLRFGYFGK 1qwj D 2.8 BS02 NCC D 1 L48 R50 N60 R109 S117 S120 Q141 Y216 L9 R11 N21 R70 S78 S81 Q102 Y177 2.7.7.43 Q99KK2 14636592 4002 PPHLAALVLARGGSKGIPLKNIKRLAGVPLIGWVLRAALDAGVFQSVWVSTDHDEIENVAKQFGAQVHRRSSETSKDSSTSLDAIVEFLNYHNEVDIVGNIQATSPCLHPTDLQKVAEMIREEGYDSVFSVVRRHQFRWSEIQKGVREVTEPLNLNPAKRPRRQDWDGELYENGSFYFAKRHLIEMGYLQGGKMAYYEMRAEHSVDIDVDIDWPIAEQRVLRFGYFGK 4zht A 2.69 BS02 NCC A 1 D53 K259 E271 A278 K280 H281 D47 K253 E265 A272 K274 H275 D112 E134 D143 H220 V222 I254 D106 E128 D137 H214 V216 I248 2.7.1.60,3.2.1.183 0004553,0006047,0008761 Q9Y223 26980148 502 NRKLRVCVATCNRADYSKLAPIMFGIKTEPEFFELDVVVLGSHLIDDYGNTYRMIEQDDFDINTRLHTIVRGEDEAAMVESVGLALVKLPDVLNRLKPDIMIVHGDRFDALALATSAALMNIRILHIEGGEVSGTIDDSIRHAITKLAHYHVCCTRSAEQHLISMCEDHDRILLAGCPSYDKLLSAKNKDYMSIIRMWLGDDVKSKDYIVALQHPVTTDIKHSIKMFELTLDALISFNKRTLVLFPNIDAGSKEMVRVMRKKGIEHHPNFRAVKHVPFDQFIQLVAHAGCMIGNSSCGVREVGAFGTPVINLGTRQIGRETGENVLHVRDADTQDKILQALHLQFGKQYPCSKIYGDGNAVPRILKFLKSIDLQEPLQKKFCFP 4zht B 2.69 BS02 NCC B 1 D53 F251 K259 V262 E271 V279 K280 H281 D46 F244 K252 V255 E264 V272 K273 H274 D112 E134 D143 H220 V222 I254 D105 E127 D136 H213 V215 I247 2.7.1.60,3.2.1.183 0004553,0006047,0008761 Q9Y223 26980148 502 RKLRVCVATCNRADYSKLAPIMFGIKTEPEFFELDVVVLGSHLIDDYGNTYRMIEQDDFDINTRLHTIVRGEDEAAMVESVGLALVKLPDVLNRLKPDIMIVHGDRFDALALATSAALMNIRILHIEGGEVSGTIDDSIRHAITKLAHYHVCCTRSAEQHLISMCEDHDRILLAGCPSYDKLLSAKNKDYMSIIRMWLGDDVKSKDYIVALQHPVTTDIKHSIKMFELTLDALISFNKRTLVLFPNIDAGSKEMVRVMRKKGIEHHPNFRAVKHVPFDQFIQLVAHAGCMIGNSSCGVREVGAFGTPVINLGTRQIGRETGENVLHVRDADTQDKILQALHLQFGKQYPCSKIYGDGNAVPRILKFLKSIDLQEPLQKKFCF 4zht C 2.69 BS02 NCC C 1 D53 F251 K259 E271 A278 V279 K280 H281 D48 F246 K254 E266 A273 V274 K275 H276 D112 E134 D143 H220 V222 I254 D107 E129 D138 H215 V217 I249 2.7.1.60,3.2.1.183 0004553,0006047,0008761 Q9Y223 26980148 502 NNRKLRVCVATCNRADYSKLAPIMFGIKTEPEFFELDVVVLGSHLIDDYGNTYRMIEQDDFDINTRLHTIVRGEDEAAMVESVGLALVKLPDVLNRLKPDIMIVHGDRFDALALATSAALMNIRILHIEGGEVSGTIDDSIRHAITKLAHYHVCCTRSAEQHLISMCEDHDRILLAGCPSYDKLLSAKNKDYMSIIRMWLGDDVKSKDYIVALQHPVTTDIKHSIKMFELTLDALISFNKRTLVLFPNIDAGSKEMVRVMRKKGIEHHPNFRAVKHVPFDQFIQLVAHAGCMIGNSSCGVREVGAFGTPVINLGTRQIGRETGENVLHVRDADTQDKILQALHLQFGKQYPCSKIYGDGNAVPRILKFLKSIDLQEPLQKKFC 4zht D 2.69 BS02 NCC D 1 D53 K259 V262 E271 V279 K280 H281 D46 K252 V255 E264 V272 K273 H274 D112 E134 D143 H220 V222 I254 D105 E127 D136 H213 V215 I247 2.7.1.60,3.2.1.183 0004553,0006047,0008761 Q9Y223 26980148 502 RKLRVCVATCNRADYSKLAPIMFGIKTEPEFFELDVVVLGSHLIDDYGNTYRMIEQDDFDINTRLHTIVRGEDEAAMVESVGLALVKLPDVLNRLKPDIMIVHGDRFDALALATSAALMNIRILHIEGGEVSGTIDDSIRHAITKLAHYHVCCTRSAEQHLISMCEDHDRILLAGCPSYDKLLSAKNKDYMSIIRMWLGDDVKSKDYIVALQHPVTTDIKHSIKMFELTLDALISFNKRTLVLFPNIDAGSKEMVRVMRKKGIEHHPNFRAVKHVPFDQFIQLVAHAGCMIGNSSCGVREVGAFGTPVINLGTRQIGRETGENVLHVRDADTQDKILQALHLQFGKQYPCSKIYGDGNAVPRILKFLKSIDLQEPLQKKFCFP 6ckm A 1.543 BS01 NCC A 1 L10 A11 R12 N22 R71 S82 Q104 Y179 F192 L10 A11 R12 N22 R71 S82 Q104 Y179 F192 2.7.7.43 0005737,0008781,0016779 P0A0Z8 31583886 701 MEKQNIAVILARQNSKGLPLKNLRKMNGISLLGHTINAAISSKCFDRIIVSTDGGLIAEEAKNFGVEVVLRPAELASDTASSISGVIHALETIGSNSGTVTLLQPTSPLRTGAHIREAFSLFDEKIKGSVVSACPMEHHPLKTLLQINNGEYAPMRHLSDLEQPRQQLPQAFRPNGAIYINDTASLIANNCFFIAPTKLYIMSHQDSIDIDTELDLQQAENILNH 6oh3 A 2.75 BS01 NCC A 1 A24 Y27 K55 Y98 Q101 N102 Y121 K124 S188 F195 Y214 G257 T260 S261 K272 A18 Y21 K49 Y92 Q95 N96 Y115 K118 S175 F182 Y201 G244 T247 S248 K259 ? 0000139,0005456,0005794,0015165,0015297,0015782,0016020,0090481 -logKd/Ki=3.32, Kd=482uM Q61420 30985278 401 NVSLFFKLYCLTVMTLVAAAYTVALRYTRTTAEELYFSTTAVCITEVIKLLISVGLLAKETGSLGRFKASLSENVLGSPKELAKLSVPSLVYAVQNNMAFLALSNLDAAVYQVTYQLKIPCTALCTVLMLNRTLSKLQWISVFMLCGGVTLVQWVVVAQNPLLGFGAIAIAVLCSGFAGVYFEKVLKSSDTSLWVRNIQMYLSGIVVTLAGTYLSDGAEIQEKGFFYGYTYYVWFVIFLASVGGLYTSVVVKYTDNIMKGFSAAAAIVLSTIASVLLFGLQITLSFALGALLVCVSIYLYGLPR 6qvt A 1.7 BS01 NCC A 1 S189 A190 N212 N233 Q235 S322 S323 G324 F343 C353 S58 A59 N81 N102 Q104 S191 S192 G193 F212 C222 P320 P189 2.4.3.1 0006486,0008373 P15907 32971290 501 GIKFSAEALRCHLRDHVNVSMVEVTDFPFNTSEWEGYLPKESIRTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQLVTTEKRFLKDSLYNEGILIVWDPSVYHSDIPKWYQNPDYNFFNNYKTYRKLHPNQPFYILKPQMPWELWDILQEISPEEIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYYQKFFDSACLLYEKNLVKHLNQGTDEDIYLLGKATLPGFRTIHC 6qvt B 1.7 BS01 NCC B 1 S189 A190 F211 N212 N233 S322 S323 G324 C353 A363 S54 A55 F76 N77 N98 S187 S188 G189 C218 A228 P320 P185 2.4.3.1 0006486,0008373 P15907 32971290 501 SAEALRCHLRDHVNVSMVEVTDFPFNTSEWEGYLPKESIRTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQLVTTEKRFLKDSLYNEGILIVWDPSVYHSDIPKWYQNPDYNFFNNYKTYRKLHPNQPFYILKPQMPWELWDILQEISPEEIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYYQKFFDSACTLLYEKNLVKHLNQGTDEDIYLLGKATLPGFRTIHC