3ho2 A 2.0 BS01 N32 A 1 T270 S271 P272 H303 T307 P308 A309 H340 F398 G399 F400 T269 S270 P271 H302 T306 P307 A308 H339 F397 G398 F399 A163 H303 E314 K335 H340 F398 F400 A162 H302 E313 K334 H339 F397 F399 2.3.1.179 0004315,0005515,0005829,0006633,0009409,0016746,0016747,0019367,0042803,0044281,1903966 ic50=113nM -logKd/Ki=6.95, IC50=113nM P0AAI5 19581087 413 KRRVVVTGLGMLSPVGNTVESTWKALLAGQSGISLIDHFDTSAYATKFAGLVKDFNCEDIISRKEQRKMDAFIQYGIVAGVQAMQDSGLEITEENATRIGAAIGSGIGGLGLIEENHTSLMNGGPRKISPFFVPSTIVNMVAGHLTIMYGLRGPSISIATAATSGVHNIGHAARIIAYGDADVMVAGGAEKASTPLGVGGFGAARALSTRNDNPQAASRPWDKERDGFVLGDGAGMLVLEEYEHAKKRGAKIYAELVGFGMSSDAYHMTSPPENGAGAALAMANALRDAGIEASQIGYVNAHGTSTPAGDKAEAQAVKTIFGEAASRVLVSSTKSMTGHLLGAAGAVESIYSILALRDQAVPPTINLDNPDEGCDLDFVPHEARQVSGMEYTLCNSFGFGGTNGSLIFKKI 4f32 A 1.9 BS02 N32 A 1 X172 T280 A281 H313 T315 T317 P318 V319 G320 H349 F407 G408 F409 X170 T278 A279 H311 T313 T315 P316 V317 G318 H347 F405 G406 F407 C172 H313 E324 K344 H349 F407 F409 C170 H311 E322 K342 H347 F405 F407 2.3.1.179 0004315,0005829,0006633,0016746,0016747 A4JL30 23382856 501 LRVVVTGIGIVSPLGCGKELVWQRLIGGGSGLRRLGDDIAGELSAKVGGTVQDVAEDPEGGFDPERSVPHKELRKMDRFIQMAMVAADEALAEAGWAPEAEQQRERTATVVASGIGGFPGLAEAVRIGETRGVRRLSPFTIPFFLSNLAAGQISIKHRFRGPLGCPVTACAASVQAIGDAMRMIRTGEADVVLAGGAEAAFDKVSLGGFAAARALSTGFSEEPVRASRPFDRDRDGFVMGEGAAMVVVESLDHALARGARPIAEIIGYGTTADAYHMTAGPDDGSGAMRAMKLALRMGDVAPEQVDYVNAHATSTPVGDAGEIEALKTVFGVGAGPAISSTKSATGHLLGAAGAIEAAFSILALRDGVLPGTLNLEHPDPAADGLDLIGPAARHVPVEIALSNGFGFGGVNASVLFRRYP 4f32 B 1.9 BS01 N32 B 1 X172 R215 F239 T280 A281 H313 T315 T317 P318 V319 G320 H349 F407 G408 F409 X173 R216 F240 T281 A282 H314 T316 T318 P319 V320 G321 H350 F408 G409 F410 C172 H313 E324 K344 H349 F407 F409 C173 H314 E325 K345 H350 F408 F410 2.3.1.179 0004315,0005829,0006633,0016746,0016747 A4JL30 23382856 500 SMTLRVVVTGIGIVSPLGCGKELVWQRLIGGGSGLRRLGDDIAGELSAKVGGTVQDVAEDPEGGFDPERSVPHKELRKMDRFIQMAMVAADEALAEAGWAPEAEQQRERTATVVASGIGGFPGLAEAVRIGETRGVRRLSPFTIPFFLSNLAAGQISIKHRFRGPLGCPVTACAASVQAIGDAMRMIRTGEADVVLAGGAEAAFDKVSLGGFAAARALSTGFSEEPVRASRPFDRDRDGFVMGEGAAMVVVESLDHALARGARPIAEIIGYGTTADAYHMTAGPDDGSGAMRAMKLALRMGDVAPEQVDYVNAHATSTPVGDAGEIEALKTVFGVGAGPAISSTKSATGHLLGAAGAIEAAFSILALRDGVLPGTLNLEHPDPAADGLDLIGPAARHVPVEIALSNGFGFGGVNASVLFRRYP 4jv3 A 1.7 BS01 N32 A 1 X161 V268 A269 P270 H296 T298 T300 P301 A302 H333 F391 G392 F393 X161 V268 A269 P270 H296 T298 T300 P301 A302 H333 F391 G392 F393 C161 H296 E307 K328 H333 F391 F393 C161 H296 E307 K328 H333 F391 F393 2.3.1.41 0004315,0005829,0006633,0016746,0016747 Q2YQQ9 31237717 500 MRRVVVTGMGIVSSIGSNTEEVTASLREAKSGISRAEEYAELGFRCQVHGAPDIDIESLVDRRAMRFHGRGTAWNHIAMDQAIADAGLTEEEVSNERTGIIMGSGGPSTRTIVDSADITREKGPKRVGPFAVPKAMSSTASATLATFFKIKGINYSISSACATSNHCIGNAYEMIQYGKQDRMFAGGCEDLDWTLSVLFDAMGAMSSKYNDTPSTASRAYDKNRDGFVIAGGAGVLVLEDLETALARGAKIYGEIVGYGATSDGYDMVAPSGEGAIRCMKMALSTVTSKIDYINPHATSTPAGDAPEIEAIRQIFGAGDVCPPIAATKSLTGHSLGATGVQEAIYSLLMMQNNFICESAHIEELDPAFADMPIVRKRIDNVQLNTVLSNSFGFGGTNATLVFQRYQG 8cn7 A 2.1 BS01 N32 A 1 Q164 T271 A272 P273 H304 T306 T308 P309 A310 H341 F398 G399 F400 Q163 T270 A271 P272 H303 T305 T307 P308 A309 H340 F397 G398 F399 2.3.1.179 0004315,0005829,0006633,0016746,0016747,0046872 G3XDA2 512 SRRRVVITGMGMLSPLGLDVPSSWEGILAGRSGIAPIEHMDLSAYSTRFGGSVKGFNVEEYLSAKEARKLDLFIQYGLAASFQAVRDSGLEVTDANRERIGVSMGSGIGGLTNIENNCRSLFEQGPRRISPFFVPGSIINMVSGFLSIHLGLQGPNYALTTAQTTGTHSIGMAARNIAYGEADVMVAGGSEMAACGLGLGGFGAARALSTRNDEPTRASRPWDRDRDGFVLSDGSGALVLEELEHARARGARIYAELVGFGMSGDAFHMTAPPEDGAGAARCMKNALRDAGLDPRQVDYINAHGTSTPAGDIAEIAAVKSVFGEHAHALSMSSTKSMTGHLLGAAGAVEAIFSVLALRDQVAPPTINLDNPDEGCDLDLVAHEAKPRKIDVALSNSFGFGGTNGTLVFRRFA 8cn7 B 2.1 BS01 N32 B 1 Q164 T271 A272 P273 H304 T306 T308 P309 H341 F398 G399 F400 Q163 T270 A271 P272 H303 T305 T307 P308 H340 F397 G398 F399 2.3.1.179 0004315,0005829,0006633,0016746,0016747,0046872 G3XDA2 514 SRRRVVITGMGMLSPLGLDVPSSWEGILAGRSGIAPIEHMDLSAYSTRFGGSVKGFNVEEYLSAKEARKLDLFIQYGLAASFQAVRDSGLEVTDANRERIGVSMGSGIGGLTNIENNCRSLFEQGPRRISPFFVPGSIINMVSGFLSIHLGLQGPNYALTTAQTTGTHSIGMAARNIAYGEADVMVAGGSEMAACGLGLGGFGAARALSTRNDEPTRASRPWDRDRDGFVLSDGSGALVLEELEHARARGARIYAELVGFGMSGDAFHMTAPPEDGAGAARCMKNALRDAGLDPRQVDYINAHGTSTPAGDIAEIAAVKSVFGEHAHALSMSSTKSMTGHLLGAAGAVEAIFSVLALRDQVAPPTINLDNPDEGCDLDLVAHEAKPRKIDVALSNSFGFGGTNGTLVFRRFA