1bzm A 2.0 BS02 MZM A 1 F91 H94 L198 T199 H200 F91 H94 L198 T199 H200 H64 H94 H96 E106 H119 T199 H64 H94 H96 E106 H119 T199 4.2.1.1,4.2.1.69 0004064,0004089,0005515,0005737,0005829,0006730,0008270,0016829,0016836,0018820,0046872,0070062 Ki=50nM, IC50=68nM P00915 7932756 262 ASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 3daz A 1.6 BS02 MZM A 1 Q92 H94 H119 V121 F131 L198 T199 Q89 H91 H116 V118 F127 L194 T195 H64 H94 H96 E106 H119 T199 H61 H91 H93 E103 H116 T195 4.2.1.1,4.2.1.69 0002009,0004064,0004089,0005515,0005737,0005829,0005886,0006730,0008270,0015670,0016829,0018820,0032230,0032849,0038166,0043209,0044070,0045177,0046872,0046903,0051453,0070050,0070062,2001150,2001225 Ki=11.8nM -logKd/Ki=7.93, Ki=11.8nM Ki=14nM, IC50=21nM, EC50=4e+1nM P00918 19170619 263 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 3dcs A 1.8 BS02 MZM A 1 Q92 H94 H119 V121 F131 L198 T199 Q89 H91 H116 V118 F127 L194 T195 H64 H94 H96 E106 H119 T199 H61 H91 H93 E103 H116 T195 4.2.1.1,4.2.1.69 0002009,0004064,0004089,0005515,0005737,0005829,0005886,0006730,0008270,0015670,0016829,0018820,0032230,0032849,0038166,0043209,0044070,0045177,0046872,0046903,0051453,0070050,0070062,2001150,2001225 Ki=11.4nM -logKd/Ki=7.94, Ki=11.4nM Ki=14nM, IC50=21nM, EC50=4e+1nM P00918 19170619 263 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHSFQVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 4k0z A 1.799 BS03 MZM A 1 Q92 H94 H119 V121 L198 T199 T200 Q90 H92 H117 V119 L195 T196 T197 H64 H94 H96 E106 H119 T199 H62 H92 H94 E104 H117 T196 4.2.1.1,4.2.1.69 0002009,0004064,0004089,0005515,0005737,0005829,0005886,0006730,0008270,0015670,0016829,0018820,0032230,0032849,0038166,0043209,0044070,0045177,0046872,0046903,0051453,0070050,0070062,2001150,2001225 Ki=14nM, IC50=21nM, EC50=4e+1nM P00918 308 HHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHSFQVTFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDLGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTEGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 4yha A 2.2 BS02 MZM A 1 N108 H110 H112 H129 V131 L190 T191 W201 N88 H90 H92 H109 V111 L168 T169 W179 H85 H110 H112 E116 H129 T191 H65 H90 H92 E96 H109 T169 ? 0004089,0008270,0046872 Ki=225nM -logKd/Ki=6.65, Ki=225nM A0A0M3KL20 26010545 303 TKWDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTQDKADLQFKYAASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNKTRPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQKKFKEVALDAFLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSPNQRPVQPDYNTVIIKSSAETR 4yha B 2.2 BS02 MZM B 1 N108 H110 H112 V131 L190 T191 N85 H87 H89 V108 L164 T165 H85 H110 H112 E116 H129 T191 H62 H87 H89 E93 H106 T165 ? 0004089,0008270,0046872 Ki=225nM A0A0M3KL20 26010545 303 TKWDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTADLQFKYAASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNKTRPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQNFKEVALDAFLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSPNQRPVQPDYNTVIIKSSAETR 4yha C 2.2 BS02 MZM C 1 N108 H110 H112 H129 V131 L190 T191 N88 H90 H92 H109 V111 L170 T171 H85 H110 H112 E116 H129 T191 H65 H90 H92 E96 H109 T171 ? 0004089,0008270,0046872 Ki=225nM A0A0M3KL20 26010545 303 TKWDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTQDKADLQFKYAASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNKTRPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQKKQNFKEVALDAFLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSPNQRPVQPDYNTVIIKSSAETR 4yha D 2.2 BS02 MZM D 1 H110 H112 H129 L190 T191 A192 H86 H88 H105 L162 T163 A164 H85 H110 H112 E116 H129 T191 H61 H86 H88 E92 H105 T163 ? 0004089,0008270,0046872 Ki=225nM A0A0M3KL20 26010545 302 WDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTQDDLQFKYAASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNKTRPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQKKEVALDAFLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSPNQRPVQPDYNTVIIKSSAETR 4yha E 2.2 BS02 MZM E 1 H110 H112 H129 L190 T191 A192 P193 H88 H90 H107 L168 T169 A170 P171 H85 H110 H112 E116 H129 T191 H63 H88 H90 E94 H107 T169 ? 0004089,0008270,0046872 Ki=225nM A0A0M3KL20 26010545 303 TKWDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTQDKLQFKYAASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNKTRPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQKKQNFKEVALDAFLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSPNQRPVQPDYNTVIIKSSAETR 4yha F 2.2 BS02 MZM F 1 D107 N108 H110 H112 V131 T191 D85 N86 H88 H90 V109 T159 H85 H110 H112 E116 H129 T191 H63 H88 H90 E94 H107 T159 ? 0004089,0008270,0046872 Ki=225nM A0A0M3KL20 26010545 302 WDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTQDKADLQFKYAASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNKTRPLSAHFVHKDAKGRLLVLAIGFEEENPNLDPILEGIQKKDAFLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSPNQRPVQPDYNTVIIKSSAETR 4yha G 2.2 BS02 MZM G 1 H110 H112 H129 V131 L190 T191 H88 H90 H107 V109 L168 T169 H85 H110 H112 E116 H129 T191 H63 H88 H90 E94 H107 T169 ? 0004089,0008270,0046872 Ki=225nM A0A0M3KL20 26010545 303 NTKWDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTQDLQFKYAASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNKTRPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQKKQNFKEVALDAFLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSPNQRPVQPDYNTVIIKSSAETR 4yha H 2.2 BS02 MZM H 1 H110 H112 H129 V131 L190 T191 H88 H90 H107 V109 L168 T169 H85 H110 H112 E116 H129 T191 H63 H88 H90 E94 H107 T169 ? 0004089,0008270,0046872 Ki=225nM A0A0M3KL20 26010545 303 WDYKNKENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTQDKADLQFKYAASKPKAVFFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNKTRPLSAHFVHKDAKGRLLVLAIGFEEGKENPNLDPILEGIQKKQNFKEVALDAFLPKSINYYHFNGSLTAPPCTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSPNQRPVQPDYNTVIIKSSAETR 5c8i A 1.56 BS02 MZM A 1 Q92 H94 F131 L198 T199 T200 Q89 H91 F127 L194 T195 T196 H64 H94 H96 E106 H119 T199 H61 H91 H93 E103 H116 T195 4.2.1.1,4.2.1.69 0002009,0004064,0004089,0005515,0005737,0005829,0005886,0006730,0008270,0015670,0016829,0018820,0032230,0032849,0038166,0043209,0044070,0045177,0046872,0046903,0051453,0070050,0070062,2001150,2001225 Ki=14nM, IC50=21nM, EC50=4e+1nM P00918 28461893 302 HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 5ku6 A 1.8 BS01 MZM A 1 Q92 H94 H119 L198 T199 T200 Q95 H97 H122 L199 T200 T201 H64 H94 H96 E106 H119 T199 H70 H97 H99 E109 H122 T200 4.2.1.1 0004089,0005515,0005791,0005793,0005794,0005802,0005886,0006730,0008270,0009897,0009986,0015701,0016020,0016323,0016324,0016829,0030658,0030667,0031526,0046872,0048471,0070062,0098552 -logKd/Ki=6.84, Kd=143nM Ki=6200nM, IC50=205nM P22748 28975383 301 AESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKS 5ku6 B 1.8 BS01 MZM B 1 Q92 H94 H119 L198 T199 T200 Q92 H94 H119 L195 T196 T197 H64 H94 H96 E106 H119 T199 H67 H94 H96 E106 H119 T196 4.2.1.1 0004089,0005515,0005791,0005793,0005794,0005802,0005886,0006730,0008270,0009897,0009986,0015701,0016020,0016323,0016324,0016829,0030658,0030667,0031526,0046872,0048471,0070062,0098552 Ki=6200nM, IC50=205nM P22748 28975383 302 HWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKS 5ku6 C 1.8 BS01 MZM C 1 Q92 H94 H96 H119 L198 T199 T200 Q93 H95 H97 H120 L204 T205 T206 H64 H94 H96 E106 H119 T199 H68 H95 H97 E107 H120 T205 4.2.1.1 0004089,0005515,0005791,0005793,0005794,0005802,0005886,0006730,0008270,0009897,0009986,0015701,0016020,0016323,0016324,0016829,0030658,0030667,0031526,0046872,0048471,0070062,0098552 Ki=6200nM, IC50=205nM P22748 28975383 301 SHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKS 5ku6 D 1.8 BS01 MZM D 1 Q92 H94 H119 L198 T199 T200 Q92 H94 H119 L203 T204 T205 H64 H94 H96 E106 H119 T199 H67 H94 H96 E106 H119 T204 4.2.1.1 0004089,0005515,0005791,0005793,0005794,0005802,0005886,0006730,0008270,0009897,0009986,0015701,0016020,0016323,0016324,0016829,0030658,0030667,0031526,0046872,0048471,0070062,0098552 Ki=6200nM, IC50=205nM P22748 28975383 301 HWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKS