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BioLiP
Download all results in tab-seperated text for 17 receptor-ligand interactions, whose format is explained at readme.txt.
  • Hover over PDB to view the title of the structure. Click PDB to view the structure at the RCSB PDB database. Resolution -1.00 means the resolution is unavailable, e.g., for NMR structures.
  • Click Site # to view the binding site structure. Hover over Site # to view the binding residues.
  • Hover over Ligand to view the full ligand name. Click Ligand to view the 2D diagram and other detail information of the ligand.
  • Hover over EC number to view the full name of enzymatic activity.
  • Hover over GO terms to view all GO terms.
  • Hover over UniProt to view the protein name.

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    # PDB
    (Resolution Å)     		Site # Ligand EC number GO terms UniProt PubMed Binding
    affinity
    1 1bzm:A (2.0) BS02 MZM 4.2.1.1
    4.2.1.69    		 GO:0004064 ... P00915 7932756 BindingDB: Ki=50nM, IC50=68nM
    2 3daz:A (1.6) BS02 MZM 4.2.1.1
    4.2.1.69    		 GO:0002009 ... P00918 19170619 MOAD: Ki=11.8nM
    PDBbind: -logKd/Ki=7.93, Ki=11.8nM
    BindingDB: Ki=14nM, IC50=21nM, EC50=4e+1nM
    3 3dcs:A (1.8) BS02 MZM 4.2.1.1
    4.2.1.69    		 GO:0002009 ... P00918 19170619 MOAD: Ki=11.4nM
    PDBbind: -logKd/Ki=7.94, Ki=11.4nM
    BindingDB: Ki=14nM, IC50=21nM, EC50=4e+1nM
    4 4k0z:A (1.799) BS03 MZM 4.2.1.1
    4.2.1.69    		 GO:0002009 ... P00918 N/A BindingDB: Ki=14nM, IC50=21nM, EC50=4e+1nM
    5 4yha:A (2.2) BS02 MZM ? GO:0004089 ... A0A0M3KL20 26010545 MOAD: Ki=225nM
    PDBbind: -logKd/Ki=6.65, Ki=225nM
    6 4yha:B (2.2) BS02 MZM ? GO:0004089 ... A0A0M3KL20 26010545 MOAD: Ki=225nM
    7 4yha:C (2.2) BS02 MZM ? GO:0004089 ... A0A0M3KL20 26010545 MOAD: Ki=225nM
    8 4yha:D (2.2) BS02 MZM ? GO:0004089 ... A0A0M3KL20 26010545 MOAD: Ki=225nM
    9 4yha:E (2.2) BS02 MZM ? GO:0004089 ... A0A0M3KL20 26010545 MOAD: Ki=225nM
    10 4yha:F (2.2) BS02 MZM ? GO:0004089 ... A0A0M3KL20 26010545 MOAD: Ki=225nM
    11 4yha:G (2.2) BS02 MZM ? GO:0004089 ... A0A0M3KL20 26010545 MOAD: Ki=225nM
    12 4yha:H (2.2) BS02 MZM ? GO:0004089 ... A0A0M3KL20 26010545 MOAD: Ki=225nM
    13 5c8i:A (1.56) BS02 MZM 4.2.1.1
    4.2.1.69    		 GO:0002009 ... P00918 28461893 BindingDB: Ki=14nM, IC50=21nM, EC50=4e+1nM
    14 5ku6:A (1.8) BS01 MZM 4.2.1.1 GO:0004089 ... P22748 28975383 PDBbind: -logKd/Ki=6.84, Kd=143nM
    BindingDB: Ki=6200nM, IC50=205nM
    15 5ku6:B (1.8) BS01 MZM 4.2.1.1 GO:0004089 ... P22748 28975383 BindingDB: Ki=6200nM, IC50=205nM
    16 5ku6:C (1.8) BS01 MZM 4.2.1.1 GO:0004089 ... P22748 28975383 BindingDB: Ki=6200nM, IC50=205nM
    17 5ku6:D (1.8) BS01 MZM 4.2.1.1 GO:0004089 ... P22748 28975383 BindingDB: Ki=6200nM, IC50=205nM
    Reference:
  • Chengxin Zhang, Xi Zhang, Peter L Freddolino, and Yang Zhang. BioLiP2: an updated structure database for biologically relevent ligand-protein interactions, Nucleic Acids Research, gkad630 (2023).
  • Jianyi Yang, Ambrish Roy, and Yang Zhang. BioLiP: a semi-manually curated database for biologically relevant ligand-protein interactions, Nucleic Acids Research, 41: D1096-D1103 (2013) (download the PDF file).

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