1ao8 A -1.00 BS01 MTX A 1 L4 A6 D26 L27 F30 R31 F49 R57 L4 A6 D26 L27 F30 R31 F49 R57 L4 L19 W21 D26 L27 F30 L54 L94 T116 L4 L19 W21 D26 L27 F30 L54 L94 T116 1.5.1.3 0004146,0005829,0006730,0016491,0031427,0046452,0046654,0046655,0046677,0050661 -logKd/Ki=8.22, IC50=6nM IC50=16nM, Ki=0.004000nM P00381 9514736 170 TAFLWAQDRDGLIGKDGHLPWHLPDDLHYFRAQTVGKIMVVGRRTYESFPKRPLPERTNVVLTHQEDYQAQGAVVVHDVAAVFAYAKQHPDQELVIAGGAQIFTAFKDDVDTLLVTRLAGSFEGDTKMIPLNWDDFTKVSSRTVEDTNPALTHTYEVWQKKA 1axw A 1.7 BS02 MTX A 1 I79 W83 L143 D169 G173 F176 A263 I79 W83 L143 D169 G173 F176 A263 E58 W80 Y94 C146 R166 D169 P175 E58 W80 Y94 C146 R166 D169 P175 2.1.1.45 0000287,0003723,0004799,0005737,0005829,0006231,0006235,0006417,0008168,0009165,0009314,0016741,0032259,0042803 IC50=90000nM P0A884 732 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 1axw B 1.7 BS03 MTX B 1 K48 H51 I79 W83 D169 L172 G173 I258 A263 K48 H51 I79 W83 D169 L172 G173 I258 A263 E58 W80 Y94 C146 R166 D169 P175 E58 W80 Y94 C146 R166 D169 P175 2.1.1.45 0000287,0003723,0004799,0005737,0005829,0006231,0006235,0006417,0008168,0009165,0009314,0016741,0032259,0042803 IC50=90000nM P0A884 733 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 1d1g A 2.1 BS02 MTX A 1 V6 L7 A8 D27 R28 K29 F31 R32 E50 I51 R53 L55 R58 I100 V6 L7 A8 D27 R28 K29 F31 R32 E50 I51 R53 L55 R58 I100 1.5.1.3 0004146,0005829,0006730,0016491,0042802,0046452,0046654,0046655,0050661 Q60034 10731419 171 AKVIFVLAMDVSGKIASSVESWSSFEDRKNFRKITTEIGNVVMGRITFEEIGRPLPERLNVVLTRRPKTSNNPSLVFFNGSPADVVKFLEGKGYERVAVIGGKTVFTEFLREKLVDELFVTVEPYVFGKGIPFFDEFEGYFPLKLLEMRRLNERGTLFLKYSVE 1d1g B 2.1 BS02 MTX B 1 V6 L7 A8 D27 R28 F31 I51 L55 R58 I100 V6 L7 A8 D27 R28 F31 I51 L55 R58 I100 1.5.1.3 0004146,0005829,0006730,0016491,0042802,0046452,0046654,0046655,0050661 Q60034 10731419 171 AKVIFVLAMDVSGKIASSVESWSSFEDRKNFRKITTEIGNVVMGRITFEEIGRPLPERLNVVLTRRPKTSNNPSLVFFNGSPADVVKFLEGKGYERVAVIGGKTVFTEFLREKLVDELFVTVEPYVFGKGIPFFDEFEGYFPLKLLEMRRLNERGTLFLKYSVE 1ddr A 2.45 BS01 MTX A 1 I5 A6 D27 F31 K32 R52 L54 R57 I94 I5 A6 D27 F31 K32 R52 L54 R57 I94 I5 M20 W22 D27 L28 F31 L54 I91 T113 I5 M20 W22 D27 L28 F31 L54 I91 T113 1.5.1.3 0004146,0005515,0005542,0005829,0006730,0009257,0009410,0016491,0031427,0046452,0046654,0046655,0046656,0046677,0050661,0051870,0051871,0070401,0070402 IC50=8.8nM, EC50=1nM P0ABQ4 9260285 200 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 1ddr B 2.45 BS01 MTX B 1 I5 A6 D27 L28 F31 I50 R52 R57 I94 I5 A6 D27 L28 F31 I50 R52 R57 I94 I5 M20 W22 D27 L28 F31 L54 I91 T113 I5 M20 W22 D27 L28 F31 L54 I91 T113 1.5.1.3 0004146,0005515,0005542,0005829,0006730,0009257,0009410,0016491,0031427,0046452,0046654,0046655,0046656,0046677,0050661,0051870,0051871,0070401,0070402 IC50=8.8nM, EC50=1nM P0ABQ4 9260285 200 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 1dds A 2.2 BS01 MTX A 1 I5 D27 L28 F31 K32 I50 R57 I94 I5 D27 L28 F31 K32 I50 R57 I94 I5 M20 W22 D27 L28 F31 L54 I91 T113 I5 M20 W22 D27 L28 F31 L54 I91 T113 1.5.1.3 0004146,0005515,0005542,0005829,0006730,0009257,0009410,0016491,0031427,0046452,0046654,0046655,0046656,0046677,0050661,0051870,0051871,0070401,0070402 IC50=8.8nM, EC50=1nM P0ABQ4 9260285 201 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 1dds B 2.2 BS01 MTX B 1 I5 A6 A7 D27 L28 F31 I50 R57 I5 A6 A7 D27 L28 F31 I50 R57 I5 M20 W22 D27 L28 F31 L54 I91 T113 I5 M20 W22 D27 L28 F31 L54 I91 T113 1.5.1.3 0004146,0005515,0005542,0005829,0006730,0009257,0009410,0016491,0031427,0046452,0046654,0046655,0046656,0046677,0050661,0051870,0051871,0070401,0070402 IC50=8.8nM, EC50=1nM P0ABQ4 9260285 201 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 1df7 A 1.7 BS02 MTX A 1 I5 W6 I20 D27 Q28 F31 R32 R60 I94 I5 W6 I20 D27 Q28 F31 R32 R60 I94 I5 I20 W22 D27 Q28 F31 L57 T91 T113 I5 I20 W22 D27 Q28 F31 L57 T91 T113 1.5.1.3 0004146,0005829,0006730,0016491,0046452,0046654,0046655,0050661,0070401 Ki=11nM IC50=8.8nM P9WNX1 10623528 501 MVGLIWAQATSGVIGRGGDIPWRLPEDQAHFREITMGHTIVMGRRTWDSLPAKVRPLPGRRNVVLSRQADFMASGAEVVGSLEEALTSPETWVIGGGQVYALALPYATRCEVTEVDIGLPREAGDALAPVLDETWRGETGEWRFSRSGLRYRLYSYHRS 1dhi A 1.9 BS01 MTX A 1 I5 A6 F31 K32 I50 R57 I94 I5 A6 F31 K32 I50 R57 I94 I5 M20 W22 S27 L28 F31 L54 I91 T113 I5 M20 W22 S27 L28 F31 L54 I91 T113 1.5.1.3 0004146,0005515,0005542,0005829,0006730,0009257,0009410,0016491,0031427,0046452,0046654,0046655,0046656,0046677,0050661,0051870,0051871,0070401,0070402 Kd=55nM -logKd/Ki=7.26, Kd=55nM IC50=8.8nM, EC50=1nM P0ABQ4 8265622 161 MISLIAALAVDRVIGMENAMPWNLPASLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 1dhi B 1.9 BS01 MTX B 1 A6 F31 K32 I50 R57 I94 A6 F31 K32 I50 R57 I94 I5 M20 W22 S27 L28 F31 L54 I91 T113 I5 M20 W22 S27 L28 F31 L54 I91 T113 1.5.1.3 0004146,0005515,0005542,0005829,0006730,0009257,0009410,0016491,0031427,0046452,0046654,0046655,0046656,0046677,0050661,0051870,0051871,0070401,0070402 Kd=55nM -logKd/Ki=7.26, Kd=55nM IC50=8.8nM, EC50=1nM P0ABQ4 8265622 361 MISLIAALAVDRVIGMENAMPWNLPASLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 1dhj A 1.8 BS01 MTX A 1 I5 A6 L28 F31 K32 I50 R52 R57 I94 I5 A6 L28 F31 K32 I50 R52 R57 I94 I5 M20 W22 S27 L28 F31 L54 I91 T113 I5 M20 W22 S27 L28 F31 L54 I91 T113 1.5.1.3 0004146,0005515,0005542,0005829,0006730,0009257,0009410,0016491,0031427,0046452,0046654,0046655,0046656,0046677,0050661,0051870,0051871,0070401,0070402 Kd=281nM -logKd/Ki=6.55, Kd=281nM IC50=8.8nM, EC50=1nM P0ABQ4 8265622 161 MISLIAALAVDRVIGMENAMPWNLPASLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVSSEFHDADAQNSHSYCFEILERR 1dhj B 1.8 BS01 MTX B 1 I5 A6 A7 L28 F31 K32 I50 R52 R57 I94 I5 A6 A7 L28 F31 K32 I50 R52 R57 I94 I5 M20 W22 S27 L28 F31 L54 I91 T113 I5 M20 W22 S27 L28 F31 L54 I91 T113 1.5.1.3 0004146,0005515,0005542,0005829,0006730,0009257,0009410,0016491,0031427,0046452,0046654,0046655,0046656,0046677,0050661,0051870,0051871,0070401,0070402 Kd=281nM -logKd/Ki=6.55, Kd=281nM IC50=8.8nM, EC50=1nM P0ABQ4 8265622 361 MISLIAALAVDRVIGMENAMPWNLPASLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVSSEFHDADAQNSHSYCFEILERR 1dls A 2.3 BS02 MTX A 1 I7 V8 E30 F31 F34 Q35 N64 L67 R70 I7 V8 E30 F31 F34 Q35 N64 L67 R70 Y22 E30 Y22 E30 1.5.1.3 0000900,0003723,0003729,0004146,0005542,0005737,0005739,0005829,0006729,0006730,0008144,0016491,0017148,0031103,0031427,0046452,0046653,0046654,0046655,0050661,0051000,0070402,1990825,2000121 Ki=10.9nM IC50=22nM, Kd=0.194984nM, Ki=4420nM, EC50=13.3nM P00374 7890613 188 VGSLNCIVAVSQNMGIGKNGDYPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND 1dra A 1.9 BS01 MTX A 1 I5 A6 E27 L28 F31 K32 I50 R52 R57 I94 I5 A6 E27 L28 F31 K32 I50 R52 R57 I94 I5 M20 W22 E27 L28 F31 L54 I91 T113 I5 M20 W22 E27 L28 F31 L54 I91 T113 1.5.1.3 0004146,0005515,0005542,0005829,0006730,0009257,0009410,0016491,0031427,0046452,0046654,0046655,0046656,0046677,0050661,0051870,0051871,0070401,0070402 IC50=8.8nM, EC50=1nM P0ABQ4 1998681 161 MISLIAALAVDRVIGMENAMPWNLPAELAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 1dra B 1.9 BS01 MTX B 1 I5 A6 A7 E27 L28 F31 K32 I50 R52 R57 I94 I5 A6 A7 E27 L28 F31 K32 I50 R52 R57 I94 I5 M20 W22 E27 L28 F31 L54 I91 T113 I5 M20 W22 E27 L28 F31 L54 I91 T113 1.5.1.3 0004146,0005515,0005542,0005829,0006730,0009257,0009410,0016491,0031427,0046452,0046654,0046655,0046656,0046677,0050661,0051870,0051871,0070401,0070402 IC50=8.8nM, EC50=1nM P0ABQ4 1998681 361 MISLIAALAVDRVIGMENAMPWNLPAELAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 1drb A 1.96 BS01 MTX A 1 I5 A6 F31 K32 I50 R57 I94 I5 A6 F31 K32 I50 R57 I94 I5 M20 W22 C27 L28 F31 L54 I91 T113 I5 M20 W22 C27 L28 F31 L54 I91 T113 1.5.1.3 0004146,0005515,0005542,0005829,0006730,0009257,0009410,0016491,0031427,0046452,0046654,0046655,0046656,0046677,0050661,0051870,0051871,0070401,0070402 IC50=8.8nM, EC50=1nM P0ABQ4 1998681 161 MISLIAALAVDRVIGMENAMPWNLPACLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 1drb B 1.96 BS01 MTX B 1 I5 A6 F31 K32 I50 R52 R57 I94 I5 A6 F31 K32 I50 R52 R57 I94 I5 M20 W22 C27 L28 F31 L54 I91 T113 I5 M20 W22 C27 L28 F31 L54 I91 T113 1.5.1.3 0004146,0005515,0005542,0005829,0006730,0009257,0009410,0016491,0031427,0046452,0046654,0046655,0046656,0046677,0050661,0051870,0051871,0070401,0070402 IC50=8.8nM, EC50=1nM P0ABQ4 1998681 361 MISLIAALAVDRVIGMENAMPWNLPACLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 1dre A 2.6 BS01 MTX A 1 I5 A6 M20 D27 L28 F31 K32 R52 R57 I94 I5 A6 M20 D27 L28 F31 K32 R52 R57 I94 I5 M20 W22 D27 L28 F31 L54 I91 T113 I5 M20 W22 D27 L28 F31 L54 I91 T113 1.5.1.3 0004146,0005515,0005542,0005829,0006730,0009257,0009410,0016491,0031427,0046452,0046654,0046655,0046656,0046677,0050661,0051870,0051871,0070401,0070402 IC50=8.8nM, EC50=1nM P0ABQ4 9012674 161 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 1e7w A 1.75 BS02 MTX A 1 S111 F113 L188 Y191 Y194 D232 M233 S103 F105 L167 Y170 Y173 D211 M212 R17 D181 Y194 R13 D160 Y173 1.5.1.33 0004155,0005829,0006729,0016491,0031427,0047040 Ki=180nM Q01782 11373620 301 TVPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAITVQADLSNVATAPVSSAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLREAMETATADLFGSNAIAPYFLIKAFAHRVAGTPAKHRGTNYSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDDMPPAVWEGHRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA 1e7w B 1.75 BS02 MTX B 1 S111 F113 Y191 Y194 W238 H241 S97 F99 Y167 Y170 W208 H211 R17 D181 Y194 R12 D157 Y170 1.5.1.33 0004155,0005829,0006729,0016491,0031427,0047040 Ki=180nM Q01782 11373620 301 VPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAITVQADLSNVATAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLRGDREAMETATADLFGSNAIAPYFLIKAFAHRVAGTPAKHRGTNYSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDWEGHRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA 1mxf A 2.3 BS02 MTX A 1 R22 S103 Y105 Y182 P218 M221 Y229 R12 S93 Y95 Y153 P189 M192 Y200 R22 D169 Y182 K186 R12 D140 Y153 K157 ? 0000166,0016491 Q8I814 16168672 1278 CPAAVITGGARRIGHSIAVRLHQQGFRVVVHYRHSEGAAQRLVAELNAARAGSAVLCKGDLSLSSSLLDCCEDIIDCSFRAFGRCDVLVNNASAYYPTPLLPKPIDAQVAELFGSNAVAPLFLIRAFARRQNLSVVNLCDAMTDLPLPGFCVYTMAKHALGGLTRAAALELAPRHIRVNAVAPGLSLLPPAMPQETQEEYRRKVPLGQSEASAAQIADAIAFLVSKDAGYITGTTLKVDGGLILARA 1mxf B 2.3 BS02 MTX B 1 R22 S103 Y105 Y182 Y229 R12 S93 Y95 Y153 Y200 R22 D169 Y182 K186 R12 D140 Y153 K157 ? 0000166,0016491 Q8I814 16168672 2278 CPAAVITGGARRIGHSIAVRLHQQGFRVVVHYRHSEGAAQRLVAELNAARAGSAVLCKGDLSLSSSLLDCCEDIIDCSFRAFGRCDVLVNNASAYYPTPLLPKPIDAQVAELFGSNAVAPLFLIRAFARRQNLSVVNLCDAMTDLPLPGFCVYTMAKHALGGLTRAAALELAPRHIRVNAVAPGLSLLPPAMPQETQEEYRRKVPLGQSEASAAQIADAIAFLVSKDAGYITGTTLKVDGGLILARA 1mxf C 2.3 BS02 MTX C 1 R22 S103 Y105 Y182 Y229 R12 S93 Y95 Y153 Y200 R22 D169 Y182 K186 R12 D140 Y153 K157 ? 0000166,0016491 Q8I814 16168672 3278 CPAAVITGGARRIGHSIAVRLHQQGFRVVVHYRHSEGAAQRLVAELNAARAGSAVLCKGDLSLSSSLLDCCEDIIDCSFRAFGRCDVLVNNASAYYPTPLLPKPIDAQVAELFGSNAVAPLFLIRAFARRQNLSVVNLCDAMTDLPLPGFCVYTMAKHALGGLTRAAALELAPRHIRVNAVAPGLSLLPPAMPQETQEEYRRKVPLGQSEASAAQIADAIAFLVSKDAGYITGTTLKVDGGLILARA 1mxf D 2.3 BS02 MTX D 1 R22 S103 Y105 Y182 M221 T225 Y229 R12 S93 Y95 Y153 M192 T196 Y200 R22 D169 Y182 K186 R12 D140 Y153 K157 ? 0000166,0016491 Q8I814 16168672 4278 CPAAVITGGARRIGHSIAVRLHQQGFRVVVHYRHSEGAAQRLVAELNAARAGSAVLCKGDLSLSSSLLDCCEDIIDCSFRAFGRCDVLVNNASAYYPTPLLPKPIDAQVAELFGSNAVAPLFLIRAFARRQNLSVVNLCDAMTDLPLPGFCVYTMAKHALGGLTRAAALELAPRHIRVNAVAPGLSLLPPAMPQETQEEYRRKVPLGQSEASAAQIADAIAFLVSKDAGYITGTTLKVDGGLILARA 1p33 A 2.86 BS02 MTX A 1 R17 S111 F113 L188 Y191 Y194 P230 Y241 R13 S101 F103 L167 Y170 Y173 P209 Y220 R17 D181 Y194 R13 D160 Y173 1.5.1.33 0006729,0016491,0031427,0047040 P42556 12925782 351 TAPVALVTGAAKRLGSSIAEALHAEGYTVCLHYHRSAADASTLAATLNARRPNSAITVQADLSNVATASSVPVTLFSRCSALVDACYMHWGRCDVLVNNASSFYPTPLLRDKESLEVAAADLFGSNAIAPYFLIKAFAQRVADTRAEQRGTSYSIVNMVDAMTSQPLLGYTMYTMAKEALEGLTRSAALELASLQIRVNGVSPGLSVLPDDMPFSVQEDYRRKVPLYQRNSSAEEVSDVVIFLCSPKAKYITGTCIKVDGGYSLTRA 1p33 B 2.86 BS02 MTX B 1 R17 S111 F113 Y191 Y194 L226 P230 M233 R15 S103 F105 Y172 Y175 L207 P211 M214 R17 D181 Y194 R15 D162 Y175 1.5.1.33 0006729,0016491,0031427,0047040 P42556 12925782 352 SPTAPVALVTGAAKRLGSSIAEALHAEGYTVCLHYHRSAADASTLAATLNARRPNSAITVQADLSNVATASSVPVTLFSRCSALVDACYMHWGRCDVLVNNASSFYPTPLLRKKESLEVAAADLFGSNAIAPYFLIKAFAQRVADTRAEQRGTSYSIVNMVDAMTSQPLLGYTMYTMAKEALEGLTRSAALELASLQIRVNGVSPGLSVLPDDMPFSVQEDYRRKVPLYQRNSSAEEVSDVVIFLCSPKAKYITGTCIKVDGGYSLTRA 1p33 C 2.86 BS02 MTX C 1 R17 S111 F113 Y191 Y194 P230 M233 Y241 R14 S102 F104 Y171 Y174 P210 M213 Y221 R17 D181 Y194 R14 D161 Y174 1.5.1.33 0006729,0016491,0031427,0047040 P42556 12925782 353 PTAPVALVTGAAKRLGSSIAEALHAEGYTVCLHYHRSAADASTLAATLNARRPNSAITVQADLSNVATASSVPVTLFSRCSALVDACYMHWGRCDVLVNNASSFYPTPLLRKKESLEVAAADLFGSNAIAPYFLIKAFAQRVADTRAEQRGTSYSIVNMVDAMTSQPLLGYTMYTMAKEALEGLTRSAALELASLQIRVNGVSPGLSVLPDDMPFSVQEDYRRKVPLYQRNSSAEEVSDVVIFLCSPKAKYITGTCIKVDGGYSLTRA 1p33 D 2.86 BS02 MTX D 1 R17 S111 F113 Y191 Y194 P230 M233 Y241 R13 S101 F103 Y171 Y174 P210 M213 Y221 R17 D181 Y194 R13 D161 Y174 1.5.1.33 0006729,0016491,0031427,0047040 P42556 12925782 354 TAPVALVTGAAKRLGSSIAEALHAEGYTVCLHYHRSAADASTLAATLNARRPNSAITVQADLSNVATASSVPVTLFSRCSALVDACYMHWGRCDVLVNNASSFYPTPLLRKDKESLEVAAADLFGSNAIAPYFLIKAFAQRVADTRAEQRGTSYSIVNMVDAMTSQPLLGYTMYTMAKEALEGLTRSAALELASLQIRVNGVSPGLSVLPDDMPFSVQEDYRRKVPLYQRNSSAEEVSDVVIFLCSPKAKYITGTCIKVDGGYSLTRA 1ra3 A 1.8 BS01 MTX A 1 I5 A6 D27 L28 F31 K32 I50 R57 I94 I5 A6 D27 L28 F31 K32 I50 R57 I94 I5 M20 W22 D27 L28 F31 L54 I91 T113 I5 M20 W22 D27 L28 F31 L54 I91 T113 1.5.1.3 0004146,0005515,0005542,0005829,0006730,0009257,0009410,0016491,0031427,0046452,0046654,0046655,0046656,0046677,0050661,0051870,0051871,0070401,0070402 IC50=8.8nM, EC50=1nM P0ABQ4 9012674 161 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 1rb3 A 2.3 BS01 MTX A 1 I5 A6 A7 D27 L28 F31 K32 I50 R57 I94 I5 A6 A7 D27 L28 F31 K32 I50 R57 I94 I5 M20 W22 D27 L28 F31 L54 I91 T113 I5 M20 W22 D27 L28 F31 L54 I91 T113 1.5.1.3 0004146,0005515,0005542,0005829,0006730,0009257,0009410,0016491,0031427,0046452,0046654,0046655,0046656,0046677,0050661,0051870,0051871,0070401,0070402 IC50=8.8nM, EC50=1nM P0ABQ4 9012674 161 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 1rb3 B 2.3 BS01 MTX B 1 I5 A6 D27 F31 L54 R57 I5 A6 D27 F31 L54 R57 I5 M20 W22 D27 L28 F31 L54 I91 T113 I5 M20 W22 D27 L28 F31 L54 I91 T113 1.5.1.3 0004146,0005515,0005542,0005829,0006730,0009257,0009410,0016491,0031427,0046452,0046654,0046655,0046656,0046677,0050661,0051870,0051871,0070401,0070402 IC50=8.8nM, EC50=1nM P0ABQ4 9012674 161 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 1rg7 A 2.0 BS01 MTX A 1 I5 A6 N18 A19 D27 L28 F31 K32 I50 L54 R57 I94 I5 A6 N18 A19 D27 L28 F31 K32 I50 L54 R57 I94 I5 M20 W22 D27 L28 F31 L54 I91 T113 I5 M20 W22 D27 L28 F31 L54 I91 T113 1.5.1.3 0004146,0005515,0005542,0005829,0006730,0009257,0009410,0016491,0031427,0046452,0046654,0046655,0046656,0046677,0050661,0051870,0051871,0070401,0070402 Kd=0.7nM IC50=8.8nM, EC50=1nM P0ABQ4 9012674 161 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 1rh3 A 2.4 BS01 MTX A 1 I5 A6 M20 D27 L28 F31 K32 R52 R57 I94 I5 A6 M20 D27 L28 F31 K32 R52 R57 I94 I5 M20 W22 D27 L28 F31 L54 I91 T113 I5 M20 W22 D27 L28 F31 L54 I91 T113 1.5.1.3 0004146,0005515,0005542,0005829,0006730,0009257,0009410,0016491,0031427,0046452,0046654,0046655,0046656,0046677,0050661,0051870,0051871,0070401,0070402 IC50=8.8nM, EC50=1nM P0ABQ4 9012674 161 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 1rx3 A 2.2 BS01 MTX A 1 I5 A6 A7 M20 D27 L28 F31 K32 L54 R57 I5 A6 A7 M20 D27 L28 F31 K32 L54 R57 I5 M20 W22 D27 L28 F31 L54 I91 T113 I5 M20 W22 D27 L28 F31 L54 I91 T113 1.5.1.3 0004146,0005515,0005542,0005829,0006730,0009257,0009410,0016491,0031427,0046452,0046654,0046655,0046656,0046677,0050661,0051870,0051871,0070401,0070402 IC50=8.8nM, EC50=1nM P0ABQ4 9012674 161 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 1tdr A 2.5 BS01 MTX A 1 I5 D27 L28 F31 K32 R52 L54 R57 I94 I5 D27 L28 F31 K32 R52 L54 R57 I94 I5 M20 W22 D27 L28 F31 L54 I91 T113 I5 M20 W22 D27 L28 F31 L54 I91 T113 1.5.1.3 0004146,0005515,0005542,0005829,0006730,0009257,0009410,0016491,0031427,0046452,0046654,0046655,0046656,0046677,0050661,0051870,0051871,0070401,0070402 IC50=8.8nM, EC50=1nM P0ABQ4 15299803 170 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFKILERR 1tdr B 2.5 BS01 MTX B 1 I5 D27 L28 F31 K32 R57 I5 D27 L28 F31 K32 R57 I5 M20 W22 D27 L28 F31 L54 I91 T113 I5 M20 W22 D27 L28 F31 L54 I91 T113 1.5.1.3 0004146,0005515,0005542,0005829,0006730,0009257,0009410,0016491,0031427,0046452,0046654,0046655,0046656,0046677,0050661,0051870,0051871,0070401,0070402 IC50=8.8nM, EC50=1nM P0ABQ4 15299803 170 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFKILERR 1u70 A 2.5 BS01 MTX A 1 I7 V8 R22 E30 F31 F34 Q35 I60 N64 K68 R70 V115 I7 V8 R22 E30 F31 F34 Q35 I60 N64 K68 R70 V115 R22 E30 R22 E30 1.5.1.3 0003723,0003729,0004146,0005634,0005737,0005739,0005829,0006729,0006730,0008144,0016491,0031103,0031427,0035094,0035999,0046452,0046653,0046654,0046655,0050661,0051000,0051871,2000121 Ki=230nM IC50=25nM, Ki=0.006000nM P00375 15681865 187 VRPLNCIVAVSQNMGIGKNGDRPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKFEVYEKKD 1u72 A 1.9 BS02 MTX A 1 I7 V8 A9 E30 F31 F34 Q35 N64 R70 I7 V8 A9 E30 F31 F34 Q35 N64 R70 L22 E30 L22 E30 1.5.1.3 0000900,0003723,0003729,0004146,0005542,0005737,0005739,0005829,0006729,0006730,0008144,0016491,0017148,0031103,0031427,0046452,0046653,0046654,0046655,0050661,0051000,0070402,1990825,2000121 Kd=0.0034nM IC50=22nM, Kd=0.194984nM, Ki=4420nM, EC50=13.3nM P00374 15681865 188 VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND 2c7v A 2.2 BS02 MTX A 1 R14 S95 F97 P99 X168 F171 Y174 P210 M213 W221 R13 S94 F96 P98 X153 F156 Y159 P195 M198 W206 R14 D161 Y174 K178 R13 D146 Y159 K163 1.5.1.33 0000166,0016491,0047040 Ki=152nM O76290 16968221 1272 EAPAAVVTGAAKRIGRAIAVKLHQTGYRVVIHYHNSAEAAVSLADELNKERSNTAVVCQADLTNSNVLPASCEEIINSCFRAFGRCDVLVNNASAFYPTPLVQGKTVETQVAELIGTNAIAPFLLTMSFAQRQKGSSNLSIVNLCDAMVDQPCMAFSLYNMGKHALVGLTQSAALELAPYGIRVNGVAPGVSLLPVAMGEEEKDKWRRKVPLGRREASAEQIADAVIFLVSGSAQYITGSIIKVDGGLSLVHA 2c7v B 2.2 BS02 MTX B 1 R14 S95 F97 P99 X168 Y174 L208 P210 M213 W221 R13 S94 F96 P98 X154 Y160 L194 P196 M199 W207 R14 D161 Y174 K178 R13 D147 Y160 K164 1.5.1.33 0000166,0016491,0047040 Ki=152nM O76290 16968221 1272 EAPAAVVTGAAKRIGRAIAVKLHQTGYRVVIHYHNSAEAAVSLADELNKERSNTAVVCQADLTNSNVLPASCEEIINSCFRAFGRCDVLVNNASAFYPTPLVQNGKTVETQVAELIGTNAIAPFLLTMSFAQRQKTSSNLSIVNLCDAMVDQPCMAFSLYNMGKHALVGLTQSAALELAPYGIRVNGVAPGVSLLPVAMGEEEKDKWRRKVPLGRREASAEQIADAVIFLVSGSAQYITGSIIKVDGGLSLVHA 2c7v C 2.2 BS02 MTX C 1 R14 S95 F97 P99 Y174 P210 M213 W221 R13 S94 F96 P98 Y166 P202 M205 W213 R14 D161 Y174 K178 R13 D153 Y166 K170 1.5.1.33 0000166,0016491,0047040 Ki=152nM O76290 16968221 1272 EAPAAVVTGAAKRIGRAIAVKLHQTGYRVVIHYHNSAEAAVSLADELNKERSNTAVVCQADLTNSNVLPASCEEIINSCFRAFGRCDVLVNNASAFYPTPLVQGGKTVETQVAELIGTNAIAPFLLTMSFAQRQKGTNPNCTSSNLSIVNLCDAMVDQPCMAFSLYNMGKHALVGLTQSAALELAPYGIRVNGVAPGVSLLPVAMGEEEKDKWRRKVPLGRREASAEQIADAVIFLVSGSAQYITGSIIKVDGGLSLVHA 2c7v D 2.2 BS02 MTX D 1 R14 S95 F97 P99 Y174 L208 P210 M213 W221 R13 S94 F96 P98 Y163 L197 P199 M202 W210 R14 D161 Y174 K178 R13 D150 Y163 K167 1.5.1.33 0000166,0016491,0047040 Ki=152nM O76290 16968221 1272 EAPAAVVTGAAKRIGRAIAVKLHQTGYRVVIHYHNSAEAAVSLADELNKERSNTAVVCQADLTNSNVLPASCEEIINSCFRAFGRCDVLVNNASAFYPTPLVQGDHNGKTVETQVAELIGTNAIAPFLLTMSFAQRQKGSSNLSIVNLCDAMVDQPCMAFSLYNMGKHALVGLTQSAALELAPYGIRVNGVAPGVSLLPVAMGEEEKDKWRRKVPLGRREASAEQIADAVIFLVSGSAQYITGSIIKVDGGLSLVHA 2drc A 1.9 BS01 MTX A 1 I5 A6 D27 F31 I50 R57 I94 I5 A6 D27 F31 I50 R57 I94 I5 M20 F22 D27 L28 F31 L54 I91 T113 I5 M20 F22 D27 L28 F31 L54 I91 T113 1.5.1.3 0004146,0005515,0005542,0005829,0006730,0009257,0009410,0016491,0031427,0046452,0046654,0046655,0046656,0046677,0050661,0051870,0051871,0070401,0070402 Kd=0.13nM -logKd/Ki=9.89, Kd=0.13nM IC50=8.8nM, EC50=1nM P0ABQ4 1932031 161 MISLIAALAVDRVIGMENAMPFNLPADLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 2drc B 1.9 BS01 MTX B 1 I5 A6 D27 L28 F31 K32 I50 R52 R57 I94 I5 A6 D27 L28 F31 K32 I50 R52 R57 I94 I5 M20 F22 D27 L28 F31 L54 I91 T113 I5 M20 F22 D27 L28 F31 L54 I91 T113 1.5.1.3 0004146,0005515,0005542,0005829,0006730,0009257,0009410,0016491,0031427,0046452,0046654,0046655,0046656,0046677,0050661,0051870,0051871,0070401,0070402 Kd=0.13nM -logKd/Ki=9.89, Kd=0.13nM IC50=8.8nM, EC50=1nM P0ABQ4 1932031 161 MISLIAALAVDRVIGMENAMPFNLPADLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 2oip A 2.8 BS02 MTX A 1 V9 V10 A11 L25 D32 L33 F36 S37 I62 L67 R70 V7 V8 A9 L23 D30 L31 F34 S35 I60 L65 R68 0004146,0004799,0006231,0006730,0016741,0046654 17580969 605 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEKKNCDPARGQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRGIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 2oip B 2.8 BS03 MTX B 1 V9 V10 A11 D32 L33 F36 S37 I62 L67 R70 V7 V8 A9 D30 L31 F34 S35 I60 L65 R68 0004146,0004799,0006231,0006730,0016741,0046654 17580969 609 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEKKNCDPARGQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRGIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 2oip C 2.8 BS02 MTX C 1 V9 V10 A11 L25 F36 S37 L67 R70 C113 V7 V8 A9 L23 F34 S35 L65 R68 C111 0004146,0004799,0006231,0006730,0016741,0046654 17580969 613 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEKCDPARGQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRGIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 2oip D 2.8 BS03 MTX D 1 V9 V10 A11 L25 D32 L33 F36 S37 I62 L67 R70 V7 V8 A9 L23 D30 L31 F34 S35 I60 L65 R68 0004146,0004799,0006231,0006730,0016741,0046654 17580969 617 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEKKCDPARGQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRGIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 2oip E 2.8 BS02 MTX E 1 V9 V10 D32 L33 F36 S37 I62 L67 R70 C113 V7 V8 D30 L31 F34 S35 I60 L65 R68 C111 0004146,0004799,0006231,0006730,0016741,0046654 17580969 621 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEKKTGQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRGIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 2qk8 A 2.4 BS01 MTX A 1 M6 V7 A8 E28 L29 V32 I51 R53 L55 R58 F96 M6 V7 A8 E28 L29 V32 I51 R53 L55 R58 F96 M6 L21 W23 E28 L29 V32 L55 I93 T115 M6 L21 W23 E28 L29 V32 L55 I93 T115 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 ic50~20nM -logKd/Ki=7.91, IC50=12.2nM IC50=15nM Q81R22 17696333 200 MIVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNIIVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAFEGDTFFPEMDMTNWKEVFVEKGLTDEKNPYTYYYHVYEKQQ 3cd2 A 2.5 BS02 MTX A 1 I10 L25 E32 I33 F36 F69 R75 I123 I10 L25 E32 I33 F36 F69 R75 I123 L25 E32 L25 E32 1.5.1.3 0004146,0005739,0006730,0016491,0046452,0046654,0046655,0050661 IC50=1nM, Ki=0.008000nM P16184 10194348 307 MNQQKSLTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFVPTFDSFESMNVVLMGRKTWESIPLQFRPLKGRINVVITRNESLDLGNGIHSAKSLDHALELLYRTYGSESSVQINRIFVIGGAQLYKAAMDHPKLDRIMATIIYKDIHCDVFFPLKFRDKEWSSVWKKEKHSDLESWVGTKVPHGKINEDGFDYEFEMWTRDL 3cl9 A 3.3 BS02 MTX A 1 V26 V27 A28 D48 M49 F52 S83 F88 L91 R94 I154 V25 V26 A27 D47 M48 F51 S82 F87 L90 R93 I145 I41 D48 E295 W317 Y343 C403 R423 D426 I40 D47 E286 W308 Y334 C394 R414 D417 1.5.1.3,2.1.1.45 0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 Q27793 18536013 602 SLFKIRMPETVAEGTRLALRAFSLVVAVDERGGIGDGRSIPWNVPEDMKFFRDVTTKLRGKNVKPSPAKRNAVVMGRKTWDSIPPKFRPLPGRLNVVLSSTLTTQHLLDNLHADSIVAVNGGLEQALQLLASPNYTPSIETVYCIGGGSVYAEALRPPCVHLLQAIYRTTIRASESSCSVFFRVPESGTEAAAGIEWQRETISEELTSANGNETKYYFEKLIPRNREEEQYLSLVDRIIREGNVKHDRTGVGTLSIFGAQMRFSLRNNRLPLLTTKRVFWRGVCEELLWFLRGETYAKKLSDKGVHIWDDNGSRAFLDSRGLTEYEEMDLGPVYGFQWRHFGAAYTHHDANYDGQGVDQIKAIVETLKTNPDDRRMLFTAWNPSALPRMALPPCHLLAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHVYSNHVEPCNEQLKRVPRAFPYLVFRREREFLEDYEEGDMEVIDYAPYPP 3dat A 2.3 BS01 MTX A 1 M6 V7 A8 L21 E28 L29 V32 I51 R53 L55 R58 F96 M6 V7 A8 L21 E28 L29 V32 I51 R53 L55 R58 F96 M6 L21 W23 E28 L29 V32 L55 I93 T115 M6 L21 W23 E28 L29 V32 L55 I93 T115 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 IC50=15nM Q81R22 19374017 201 MIVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNIIVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAFEGDTFFPEMDMTNWKEVFVEKGLTDEKNPYTYYYHVYEKQ 3dau A 1.5 BS01 MTX A 1 I5 A6 M20 D27 L28 F31 K32 I50 R52 L54 R57 I94 I5 A6 M20 D27 L28 F31 K32 I50 R52 L54 R57 I94 I5 M20 W22 D27 L28 F31 L54 I91 T113 I5 M20 W22 D27 L28 F31 L54 I91 T113 1.5.1.3 0004146,0005515,0005542,0005829,0006730,0009257,0009410,0016491,0031427,0046452,0046654,0046655,0046656,0046677,0050661,0051870,0051871,0070401,0070402 IC50=8.8nM, EC50=1nM P0ABQ4 19374017 201 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 3dfr A 1.7 BS02 MTX A 1 L4 W5 L19 D26 L27 H28 F30 R31 F49 P50 R57 L4 W5 L19 D26 L27 H28 F30 R31 F49 P50 R57 L4 L19 W21 D26 L27 F30 L54 L94 T116 L4 L19 W21 D26 L27 F30 L54 L94 T116 1.5.1.3 0004146,0005829,0006730,0016491,0031427,0046452,0046654,0046655,0046677,0050661 ic50=3nM IC50=16nM, Ki=0.004000nM P00381 6815178 164 TAFLWAQNRNGLIGKDGHLPWHLPDDLHYFRAQTVGKIMVVGRRTYESFPKRPLPERTNVVLTHQEDYQAQGAVVVHDVAAVFAYAKQHLDQELVIAGGAQIFTAFKDDVDTLLVTRLAGSFEGDTKMIPLNWDDFTKVSSRTVEDTNPALTHTYEVWQKKA 3drc A 1.9 BS01 MTX A 1 I5 A6 D27 F31 K32 I50 R57 I94 I5 A6 D27 F31 K32 I50 R57 I94 I5 M20 W22 D27 L28 F31 L54 I91 T113 I5 M20 W22 D27 L28 F31 L54 I91 T113 1.5.1.3 0004146,0005515,0005542,0005829,0006730,0009257,0009410,0016491,0031427,0046452,0046654,0046655,0046656,0046677,0050661,0051870,0051871,0070401,0070402 Kd=0.7nM IC50=8.8nM, EC50=1nM P0ABQ4 1932031 161 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 3drc B 1.9 BS01 MTX B 1 I5 A6 D27 F31 K32 I50 R52 R57 I94 I5 A6 D27 F31 K32 I50 R52 R57 I94 I5 M20 W22 D27 L28 F31 L54 I91 T113 I5 M20 W22 D27 L28 F31 L54 I91 T113 1.5.1.3 0004146,0005515,0005542,0005829,0006730,0009257,0009410,0016491,0031427,0046452,0046654,0046655,0046656,0046677,0050661,0051870,0051871,0070401,0070402 Kd=0.7nM IC50=8.8nM, EC50=1nM P0ABQ4 1932031 361 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR 3eig A 1.7 BS01 MTX A 1 I7 V8 L22 E30 R31 R32 F34 E35 N64 L67 R70 V115 I7 V8 L22 E30 R31 R32 F34 E35 N64 L67 R70 V115 L22 E30 L22 E30 1.5.1.3 0000900,0003723,0003729,0004146,0005542,0005737,0005739,0005829,0006729,0006730,0008144,0016491,0017148,0031103,0031427,0046452,0046653,0046654,0046655,0050661,0051000,0070402,1990825,2000121 Ki=21nM -logKd/Ki=7.68, Ki=21nM IC50=22nM, Kd=0.194984nM, Ki=4420nM, EC50=13.3nM P00374 19478082 200 VGSLNCIVAVSQNMGIGKNGDLPWPPLRNERRYFERMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND 3hj3 A 2.7 BS02 MTX A 1 V9 V10 A11 D32 L33 F36 S37 I62 L67 R70 V7 V8 A9 D30 L31 F34 S35 I60 L65 R68 0004146,0004799,0006231,0006730,0016741,0046654 24324854 605 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEKQLKSIDDTVDLLGEIAGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 3hj3 B 2.7 BS03 MTX B 1 V9 V10 A11 D32 L33 F36 S37 I62 L67 R70 V7 V8 A9 D30 L31 F34 S35 I60 L65 R68 0004146,0004799,0006231,0006730,0016741,0046654 24324854 609 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEKRGQLKSIDDTVDLLGEIAGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 3hj3 C 2.7 BS02 MTX C 1 V9 V10 A11 L25 D32 L33 F36 S37 L67 R70 V7 V8 A9 L23 D30 L31 F34 S35 L65 R68 0004146,0004799,0006231,0006730,0016741,0046654 24324854 613 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEKKTQLKSIDDTVDLLGEIAGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 3hj3 D 2.7 BS02 MTX D 1 V9 V10 A11 L25 D32 L33 F36 S37 I62 L67 R70 C113 V7 V8 A9 L23 D30 L31 F34 S35 I60 L65 R68 C111 0004146,0004799,0006231,0006730,0016741,0046654 24324854 615 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQLKSIDDTVDLLGEIAGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 3ia4 A 1.7 BS02 MTX A 1 I6 A7 M21 E28 L29 F32 K33 I51 R53 R58 I96 I6 A7 M21 E28 L29 F32 K33 I51 R53 R58 I96 I6 M21 W23 E28 L29 F32 L55 L93 T115 I6 M21 W23 E28 L29 F32 L55 L93 T115 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0050661 Q70YQ6 19681091 164 MIVSMIAALANNRVIGLDNKMPWHLPAELQLFKRATLGKPIVMGRNTFESIGRPLPGRLNIVLSRQTDYQPEGVTVVATLEDAVVAAGDVEELMIIGGATIYNQCLAAADRLYLTHIELTTEGDTWFPDYEQYNWQEIEHESYAADDKNPHNYRFSLLERV 3ia4 B 1.7 BS02 MTX B 1 I6 A7 M21 E28 L29 F32 K33 I51 R53 R58 I96 I6 A7 M21 E28 L29 F32 K33 I51 R53 R58 I96 I6 M21 W23 E28 L29 F32 L55 L93 T115 I6 M21 W23 E28 L29 F32 L55 L93 T115 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0050661 Q70YQ6 19681091 164 MIVSMIAALANNRVIGLDNKMPWHLPAELQLFKRATLGKPIVMGRNTFESIGRPLPGRLNIVLSRQTDYQPEGVTVVATLEDAVVAAGDVEELMIIGGATIYNQCLAAADRLYLTHIELTTEGDTWFPDYEQYNWQEIEHESYAADDKNPHNYRFSLLERV 3ia4 C 1.7 BS02 MTX C 1 I6 A7 A8 M21 E28 L29 F32 K33 I51 R53 R58 I96 I6 A7 A8 M21 E28 L29 F32 K33 I51 R53 R58 I95 I6 M21 W23 E28 L29 F32 L55 L93 T115 I6 M21 W23 E28 L29 F32 L55 L92 T114 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0050661 Q70YQ6 19681091 164 MIVSMIAALANNRVIGLDNKMPWHLPAELQLFKRATLGKPIVMGRNTFESIGRPLPGRLNIVLSRQDYQPEGVTVVATLEDAVVAAGDVEELMIIGGATIYNQCLAAADRLYLTHIELTTEGDTWFPDYEQYNWQEIEHESYAADDKNPHNYRFSLLERV 3ia4 D 1.7 BS02 MTX D 1 I6 A7 A8 M21 E28 L29 F32 K33 I51 R53 L55 R58 I96 I6 A7 A8 M21 E28 L29 F32 K33 I51 R53 L55 R58 I96 I6 M21 W23 E28 L29 F32 L55 L93 T115 I6 M21 W23 E28 L29 F32 L55 L93 T115 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0050661 Q70YQ6 19681091 164 MIVSMIAALANNRVIGLDNKMPWHLPAELQLFKRATLGKPIVMGRNTFESIGRPLPGRLNIVLSRQTDYQPEGVTVVATLEDAVVAAGDVEELMIIGGATIYNQCLAAADRLYLTHIELTTEGDTWFPDYEQYNWQEIEHESYAADDKNPHNYRFSLLERV 3ix9 A 1.95 BS02 MTX A 1 I8 W9 L23 E30 L31 F34 K35 L58 R61 V100 I7 W8 L22 E29 L30 F33 K34 L57 R60 V99 I8 L23 W25 E30 L31 F34 L58 L97 T119 I7 L22 W24 E29 L30 F33 L57 L96 T118 1.5.1.3 0004146,0005515,0005829,0006730,0016491,0046452,0046654,0046655,0046677,0050661 Ki=3.9nM Q54801 19950924 200 TKKIVAIWAQDEEGVIGKDNRLPWYLPAELQHFKETTLNHAILMGRVTFDGMGRRLLPKRETLILTRNPEEKIDGVATFHDVQSVLDWYSAQEKNLYIVGGKQIFQAFEPYLDEVIVTHIHARVEGDTYFPAEFDLSLFETVSSKFYTKDEKNPYDFTIQYRKRKE 3ix9 B 1.95 BS02 MTX B 1 I8 W9 L23 E30 L31 Q32 F34 K35 L58 R61 V100 I7 W8 L22 E29 L30 Q31 F33 K34 L57 R60 V99 I8 L23 W25 E30 L31 F34 L58 L97 T119 I7 L22 W24 E29 L30 F33 L57 L96 T118 1.5.1.3 0004146,0005515,0005829,0006730,0016491,0046452,0046654,0046655,0046677,0050661 Ki=3.9nM Q54801 19950924 200 TKKIVAIWAQDEEGVIGKDNRLPWYLPAELQHFKETTLNHAILMGRVTFDGMGRRLLPKRETLILTRNPEEKIDGVATFHDVQSVLDWYSAQEKNLYIVGGKQIFQAFEPYLDEVIVTHIHARVEGDTYFPAEFDLSLFETVSSKFYTKDEKNPYDFTIQYRKRKE 3qxt A 1.7 BS01 MTX A 1 V4 A26 R28 R29 S30 R32 W34 M36 R74 N79 T80 V81 V2 A24 R26 R27 S28 R30 W32 M34 R72 N77 T78 V79 Kd=6700nM -logKd/Ki=5.22, Kd=6uM 21557375 2000 QVQLVESGGGLVQAGGSLRLSCAASRRSSRSWAMAWFRQAPGKEREFVAKISGDGRLTTYGDSVKGRFTISRDKGKNTVYLQMDSLKPEDTAVYYCAADDNYVTASWRSGPDYWGQGTQVTVSS 3qxt B 1.7 BS01 MTX B 1 V4 A26 R28 R29 S30 S31 R32 W34 M36 R74 N79 T80 V81 Y120 V2 A24 R26 R27 S28 S29 R30 W32 M34 R72 N77 T78 V79 Y113 Kd=6700nM 21557375 2000 QVQLVESGGGLVQAGGSLRLSCAASRRSSRSWAMAWFRQAPGKEREFVAKISGDGRLTTYGDSVKGRFTISRDKGKNTVYLQMDSLKPEDTAVYYCAADDNYVTASWRSGPDYWGQGTQVTVSS 3qxv A 2.5 BS01 MTX A 1 V4 A26 S30 S31 W34 M36 R74 N76 Y79 L80 V81 V1 A23 S27 S28 W31 M33 R71 N73 Y76 L77 V78 Kd=5nM -logKd/Ki=8.40, Kd=4nM 21557375 2000 VQLVESGGGLVQAGGSLRLSCAASRRSSRSWAMAWFRQAPGKEREFVAKISGDGRLTTYGDSVKGRFTISRDNAEYLVYLQMDSLKPEDTAVYYCAADDNYVTASWRSGPDYWGQGTQVTVSS 3qxv B 2.5 BS01 MTX B 1 V4 A26 R28 S30 S31 W34 D75 Y79 L80 V81 Y120 V1 A23 R25 S27 S28 W31 D72 Y76 L77 V78 Y112 Kd=5nM 21557375 2000 VQLVESGGGLVQAGGSLRLSCAASRRSSRSWAMAWFRQAPGKEREFVAKISGDGRLTTYGDSVKGRFTISRDNAEYLVYLQMDSLKPEDTAVYYCAADDNYVTASWRSGPDYWGQGTQVTVSS 3qxv C 2.5 BS01 MTX C 1 V4 A26 R28 S30 W34 M36 R74 Y79 L80 V81 V1 A23 R25 S27 W31 M33 R71 Y76 L77 V78 Kd=5nM 21557375 2000 VQLVESGGGLVQAGGSLRLSCAASRRSSRSWAMAWFRQAPGKEREFVAKISGDGRLTTYGDSVKGRFTISRDNAEYLVYLQMDSLKPEDTAVYYCAADDNYVTASWRSGPDYWGQGTQVTVSS 3qxv D 2.5 BS01 MTX D 1 V4 A26 R28 S30 S31 W34 R74 N76 Y79 L80 V81 Y120 V2 A24 R26 S28 S29 W32 R72 N74 Y77 L78 V79 Y113 Kd=5nM 21557375 2000 QVQLVESGGGLVQAGGSLRLSCAASRRSSRSWAMAWFRQAPGKEREFVAKISGDGRLTTYGDSVKGRFTISRDNAEYLVYLQMDSLKPEDTAVYYCAADDNYVTASWRSGPDYWGQGTQVTVSS 3qxv E 2.5 BS01 MTX E 1 C24 R28 S30 S31 W34 M36 Y79 L80 Y120 C17 R21 S23 S24 W27 M29 Y69 L70 Y104 Kd=5nM 21557375 2000 VQLVESGQAGGSLRLSCAASRRSSRSWAMAWFRAKEREFVAKISGDGRLTTYGDSVKGRFTISRDNAEYLVYLQMDLKPEDTAVYYCAADDNYVTASWRSGPDYWGQGTQVTV 3tq9 A 2.3 BS02 MTX A 1 I6 A7 A8 L21 D28 F32 K33 I51 L55 R58 I6 A7 A8 L21 D28 F32 K33 I51 L55 R58 I6 L21 W23 D28 L29 F32 L55 V93 T115 I6 L21 W23 D28 L29 F32 L55 V93 T115 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0050661 Q83AB2 26033498 2001 MIITLIAAMDKNRLIGRNNELPWHLPADLAHFKSITLGKPIVMGRRTFDSIGKPLPHRRNIVITQQKNLIIEGCDIFYSLDDALSALTKEPEVIIIGGARIFKEALPKADKMILTIINHSFEGDVYFPEWNDKEWKITSQIKHFQFLELRR 4dfr A 1.7 BS01 MTX A 1 I5 A6 D27 F31 K32 I50 R52 L54 R57 I94 I5 A6 D27 F31 K32 I50 R52 L54 R57 I94 I5 M20 W22 D27 L28 F31 L54 I91 T113 I5 M20 W22 D27 L28 F31 L54 I91 T113 1.5.1.3 0004146,0005515,0005542,0005829,0006730,0009257,0009410,0016491,0031427,0046452,0046654,0046655,0046656,0046677,0050661,0051870,0051871,0070401,0070402 IC50=8.8nM, EC50=1nM P0ABQ4 6815178 161 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFKILERR 4dfr B 1.7 BS01 MTX B 1 I5 A6 A7 D27 L28 F31 K32 I50 R52 L54 R57 I94 I5 A6 A7 D27 L28 F31 K32 I50 R52 L54 R57 I94 I5 M20 W22 D27 L28 F31 L54 I91 T113 I5 M20 W22 D27 L28 F31 L54 I91 T113 1.5.1.3 0004146,0005515,0005542,0005829,0006730,0009257,0009410,0016491,0031427,0046452,0046654,0046655,0046656,0046677,0050661,0051870,0051871,0070401,0070402 IC50=8.8nM, EC50=1nM P0ABQ4 6815178 162 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFKILERR 4gh8 A 1.85 BS01 MTX A 1 I5 A6 M20 D28 F32 K33 N55 R61 I5 A6 M20 D28 F32 K33 N55 R61 I5 M20 W22 D28 L29 F32 L58 I95 T117 I5 M20 W22 D28 L29 F32 L58 I95 T117 1.5.1.3 0004146,0046654,0050661 IC50=8.8nM, EC50=1nM P0ABQ4 23733948 201 MISLIAALAVDRVIGMENAMPWPPLPADLAWFKRNTLNKPVIMGRHTWESIPEKNRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 4gh8 B 1.85 BS01 MTX B 1 I5 A6 A7 M20 D28 L29 F32 K33 P52 N55 R61 I5 A6 A7 M20 D28 L29 F32 K33 P52 N55 R61 I5 M20 W22 D28 L29 F32 L58 I95 T117 I5 M20 W22 D28 L29 F32 L58 I95 T117 1.5.1.3 0004146,0046654,0050661 IC50=8.8nM, EC50=1nM P0ABQ4 23733948 201 MISLIAALAVDRVIGMENAMPWPPLPADLAWFKRNTLNKPVIMGRHTWESIPEKNRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILER 4kn0 A 2.1 BS01 MTX A 1 Y76 F78 Y101 Q116 W118 H151 R152 G153 W154 W156 W187 S190 Y53 F55 Y78 Q93 W95 H128 R129 G130 W131 W133 W164 S167 ? Kd=40nM -logKd/Ki=7.40, Kd=40nM IC50=106nM P14207 23934049 301 RTDLLNVCMDAKHHKTKPGPEDKLHDQCSPWKKNACCTASTSQELHKDTSRLYNFNWDHCGKMEPACKRHFIQDTCLYECSPNLGPWIQQVNQSWRKERFLDVPLCKEDCQRWWEDCHTSHTCKSNWHRGWDWTSGVNKCPAGALCRTFESYFPTPAALCEGLWSHSYKVSNYSRGSGRCIQMWFDSAQGNPNEEVARFYAAAMH 4ky8 A 3.084 BS03 MTX A 1 V9 V10 A11 D32 L33 K34 F36 S37 I62 R70 C113 T134 V7 V8 A9 D30 L31 K32 F34 S35 I60 R68 C111 T132 0004146,0004799,0006231,0006730,0016741,0046654 23927969 603 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 4ky8 B 3.084 BS04 MTX B 1 V9 V10 A11 D32 K34 F36 S37 I62 R70 C113 T134 V7 V8 A9 D30 K32 F34 S35 I60 R68 C111 T132 0004146,0004799,0006231,0006730,0016741,0046654 23927969 603 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 4ky8 C 3.084 BS03 MTX C 1 V9 V10 A11 D32 L33 K34 F36 S37 I62 R70 C113 V7 V8 A9 D30 L31 K32 F34 S35 I60 R68 C111 0004146,0004799,0006231,0006730,0016741,0046654 23927969 603 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 4ky8 D 3.084 BS04 MTX D 1 V9 V10 A11 L25 D32 K34 F36 S37 I62 R70 C113 T134 V7 V8 A9 L23 D30 K32 F34 S35 I60 R68 C111 T132 0004146,0004799,0006231,0006730,0016741,0046654 23927969 603 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 4ky8 E 3.084 BS03 MTX E 1 V9 V10 A11 L25 D32 L33 F36 S37 I62 L67 R70 C113 T134 V7 V8 A9 L23 D30 L31 F34 S35 I60 L65 R68 C111 T132 0004146,0004799,0006231,0006730,0016741,0046654 23927969 603 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 4l6h A 1.75 BS02 MTX A 1 K19 D504 R530 Y531 V532 W576 K19 D502 R528 Y529 V530 W574 2.1.1.14 0003871,0005634,0006555,0006696,0008168,0008172,0008270,0008652,0009086,0009277,0009986,0019280,0030446,0032259,0034605,0046872,0052553,0062040,0071266 ic50=4mM P82610 24524835 803 MVQSSVLGFPRIGGQRELKKITEAYWSGKATVEELLAKGKELREHNWKLQQKAGVDIIPSNDFSYYDQVLDLSLLFNAIPERYTKFDLAPIDVLFAMGRGLQAAATQAAVDVTALEMVKWFDSNYHYVRPTFSHSTEFKLNTAAGIKPVDEFNEAKALGVQTRPVILGPVSYLYLGKADKDSLDLEPISLLPKILPVYKELLQKLKEAGAEQVQIDEPVLVLDLPEAVQSKFKEAYDALVGADVPELILTTYFGDVRPNLKAIENLPVAGFHFDFVRVPEQLDEVASILKDGQTLSAGVVDGRNIWKTDFAKASAVVQKAIEKVGKDKVVVATSSSLLHTPVDLESETKLDAVIKDWFSFATQKLDEVVVIAKNVSGEDVSKQLEANAASIKARSESSITNDPKVQERLTTINEALATRKAAFPERLTEQKAKYNLPLFPTTTIGSFPQTKDIRINRNKFAKGQITAEEYEAFINKEIETVVRFQEEIGLDVLVHGEPERNDMVQYFGEQLNGFAFTTNGWVQSYGSRYVRPPIIVGDVSRPKAMTVKESVYAQSITSKPMKGMLTGPVTILRWSFPRDDVSGKIQALQLGLALRDEVNDLEGAGITVIQVDEPAIREGLPLRAGKERSDYLNWAAQSFRVATSGVENSTQIHSHFCLDPNHIKALDADVVSIEFSKDDPNYIQEFSEYPNHIGLGLFDIHSPRIPSKQEFVSRIEEILKVYPASKFWVNPDCGLKTRGWPEVKESLTNMVEAAKEFRAKY 4l8f B 1.97 BS01 MTX B 1 F20 G71 G72 G73 A108 L109 E112 S168 H169 Q170 W171 H218 F16 G67 G68 G69 A104 L105 E108 S164 H165 Q166 W167 H214 A108 H218 E220 A104 H214 E216 3.4.19.9 0008242,0016787 Q6NY42 24028568 301 KTNERPIIGVLAQDVFDPKPDRNSYIAASYVKFLESAGARVVPVMINKSEDEYSRLFKSINGVLFPGGGVSLESSGYSKAAGIFYRLALEANSNGDYFPVWGTALGFELLTLLTSGELLLSHTNTSGIALPLDFTEDVKGSRLFKEFPEELMKSLATEPLTENSHQWSITTENFTANKKLKKFYRVLSTNTDGYNKFVSTMEAYDFPIYATQWHPEKNAFEWTRPYIPHTPSAIKTTFYMANFFVNEARKNLHSFASTEEEEKALIYNYKPEYTGIQSAFEQTYFFN 4l8f D 1.97 BS01 MTX D 1 F20 G71 G72 G73 A108 L109 E112 S168 H169 Q170 W171 H218 F16 G67 G68 G69 A104 L105 E108 S164 H165 Q166 W167 H214 A108 H218 E220 A104 H214 E216 3.4.19.9 0008242,0016787 Q6NY42 24028568 301 KTNERPIIGVLAQDVFDPKPDRNSYIAASYVKFLESAGARVVPVMINKSEDEYSRLFKSINGVLFPGGGVSLESSGYSKAAGIFYRLALEANSNGDYFPVWGTALGFELLTLLTSGELLLSHTNTSGIALPLDFTEDVKGSRLFKEFPEELMKSLATEPLTENSHQWSITTENFTANKKLKKFYRVLSTNTDGYNKFVSTMEAYDFPIYATQWHPEKNAFEWTRPYIPHTPSAIKTTFYMANFFVNEARKNLHSFASTEEEEKALIYNYKPEYTGIQSAFEQTYFFN 4l8w G 2.39 BS01 MTX G 1 F20 G71 G72 G73 C108 L109 E112 H169 Q170 W171 F16 G67 G68 G69 C104 L105 E108 H165 Q166 W167 E220 E216 3.4.19.9 0008242,0016787 Q6NY42 24028568 301 KTNERPIIGVLAQDVFDPKPDRNSYIAASYVKFLESAGARVVPVMINKSEDEYSRLFKSINGVLFPGGGVSLESSGYSKAAGIFYRLALEANSNGDYFPVWGTCLGFELLTLLTSGELLLSHTNTSGIALPLDFTEDVKGSRLFKEFPEELMKSLATEPLTENSHQWSITTENFTANKKLKKFYRVLSTNTDGYNKFVSTMEAYDFPIYATQWNPEKNAFEWTRPYIPHTPSAIKTTFYMANFFVNEARKNLHSFASTEEEEKALIYNYKPEYTGIQSAFEQTYFFN 4l8w I 2.39 BS01 MTX I 1 F20 G72 G73 C108 L109 E112 H169 Q170 W171 F16 G68 G69 C104 L105 E108 H165 Q166 W167 E220 E216 3.4.19.9 0008242,0016787 Q6NY42 24028568 301 KTNERPIIGVLAQDVFDPKPDRNSYIAASYVKFLESAGARVVPVMINKSEDEYSRLFKSINGVLFPGGGVSLESSGYSKAAGIFYRLALEANSNGDYFPVWGTCLGFELLTLLTSGELLLSHTNTSGIALPLDFTEDVKGSRLFKEFPEELMKSLATEPLTENSHQWSITTENFTANKKLKKFYRVLSTNTDGYNKFVSTMEAYDFPIYATQWNPEKNAFEWTRPYIPHTPSAIKTTFYMANFFVNEARKNLHSFASTEEEEKALIYNYKPEYTGIQSAFEQTYFFN 4p66 A 1.84 BS01 MTX A 1 I5 A6 A7 M20 D27 L28 F31 K32 X46 R57 I94 I5 A6 A7 M20 D27 L28 F31 K32 X46 R57 I94 I5 M20 W22 D27 L28 F31 L54 I91 T113 I5 M20 W22 D27 L28 F31 L54 I91 T113 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 C3TR70 24977791 201 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHCWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDEAIAAAGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYSFEILERR 4p68 A 2.26 BS01 MTX A 1 I5 A6 M20 D27 F31 I50 X54 R57 I94 I5 A6 M20 D27 F31 I50 X54 R57 I94 I5 M20 W22 D27 L28 F31 C54 I91 T113 I5 M20 W22 D27 L28 F31 C54 I91 T113 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 C3TR70 24977791 201 MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPCPGRKNIILSSQPGTDDRVTWVKSVDEAIAAAGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEFHDADAQNSHSYSFEILERR 4q0d A 3.449 BS05 MTX A 1 V9 V10 A11 D32 L33 K34 F36 S37 I62 L67 R70 V7 V8 A9 D30 L31 K32 F34 S35 I60 L65 R68 0004146,0004799,0006231,0006730,0016741,0046654 25127103 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEKKLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 4q0d B 3.449 BS04 MTX B 1 V9 V10 A11 D32 L33 F36 S37 I62 R70 V7 V8 A9 D30 L31 F34 S35 I60 R68 0004146,0004799,0006231,0006730,0016741,0046654 25127103 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEKKLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 4q0d C 3.449 BS05 MTX C 1 V9 V10 A11 L25 D32 L33 K34 F36 S37 I62 L67 R70 V7 V8 A9 L23 D30 L31 K32 F34 S35 I60 L65 R68 0004146,0004799,0006231,0006730,0016741,0046654 25127103 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEKKLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 4q0d D 3.449 BS04 MTX D 1 V9 V10 A11 L25 D32 L33 K34 F36 S37 I62 L67 R70 V7 V8 A9 L23 D30 L31 K32 F34 S35 I60 L65 R68 0004146,0004799,0006231,0006730,0016741,0046654 25127103 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEKKLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 4q0d E 3.449 BS04 MTX E 1 V9 V10 A11 D32 K34 F36 S37 I62 R70 T134 V7 V8 A9 D30 K32 F34 S35 I60 R68 T132 0004146,0004799,0006231,0006730,0016741,0046654 25127103 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEKKLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 4qi9 A 2.297 BS01 MTX A 1 I6 A7 D28 F32 I51 L55 R58 M95 I6 A7 D19 F23 I42 L46 R49 M86 I6 D28 L29 F32 L55 V92 T114 I6 D19 L20 F23 L46 V83 T105 1.5.1.3 0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 A0A3N4BLI0 201 MIISLIAALAADRVILPADLAWFKRNTLNKPVIMGRKTFESIGRPLPGRLNIVISSQPGTDERVTWAASIEEALAFAGNAEEVMVMGGGRVYKQFLDRANRMYLTHIDAEVGGDTHFPDYEPDEWESVFSEFHDADEANSHSYCFEILERRGENLYFQ 4qi9 B 2.297 BS01 MTX B 1 I6 A7 D28 K33 R53 R58 M95 I6 A7 D20 K25 R45 R50 M87 I6 D28 L29 F32 L55 V92 T114 I6 D20 L21 F24 L47 V84 T106 1.5.1.3 0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 A0A3N4BLI0 201 MIISLIAALAADRVIHLPADLAWFKRNTLNKPVIMGRKTFESIGRPLPGRLNIVISSQPGTDERVTWAASIEEALAFAGNAEEVMVMGGGRVYKQFLDRANRMYLTHIDAEVGGDTHFPDYEPDEWESVFSEFHDADEANSHSYCFEILERRGENLYFQ 4qi9 C 2.297 BS01 MTX C 1 I6 A7 A8 D28 F32 K33 R53 L55 R58 M95 I6 A7 A8 D20 F24 K25 R45 L47 R50 M87 I6 D28 L29 F32 L55 V92 T114 I6 D20 L21 F24 L47 V84 T106 1.5.1.3 0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 A0A3N4BLI0 201 MIISLIAALAADRVIHLPADLAWFKRNTLNKPVIMGRKTFESIGRPLPGRLNIVISSQPGTDERVTWAASIEEALAFAGNAEEVMVMGGGRVYKQFLDRANRMYLTHIDATHFPDYEPDEWESVFSEFHDADEANSHSYCFEILERRGENLYFQ 5hi6 A 2.051 BS01 MTX A 1 I6 A7 D28 F32 K33 I51 R58 M95 I7 A8 D29 F33 K34 I52 R59 M96 I6 M21 W23 D28 L29 F32 L55 V92 T114 I7 M22 W24 D29 L30 F33 L56 V93 T115 1.5.1.3 0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 A0A3N4BLI0 201 AMIISLIAALAADRVIGMENAMPWHLPADLAWFKRNTLNKPVIMGRKTFESIGRPLPGRLNIVISSQPGTDERVTWAASIEEALAFAGNAEEVMVMGGGRVYKQFLDRANRMYLTHIDAEVGGDTHFPDYEPDEWESVFSEFHDADEANSHSYCFEILERR 5hi6 B 2.051 BS01 MTX B 1 I6 A7 A8 D28 L29 F32 K33 S50 R53 R58 M95 I8 A9 A10 D30 L31 F34 K35 S52 R55 R60 M97 I6 M21 W23 D28 L29 F32 L55 V92 T114 I8 M23 W25 D30 L31 F34 L57 V94 T116 1.5.1.3 0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 A0A3N4BLI0 201 NAMIISLIAALAADRVIGMENAMPWHLPADLAWFKRNTLNKPVIMGRKTFESIGRPLPGRLNIVISSQPGTDERVTWAASIEEALAFAGNAEEVMVMGGGRVYKQFLDRANRMYLTHIDAEVGGDTHFPDYEPDEWESVFSEFHDADEANSHSYCFEILERR 5j7w C 2.5 BS01 MTX C 1 L55 I80 W81 W84 L194 D220 L223 G224 F227 Y260 I313 A314 L55 I80 W81 W84 L194 D220 L223 G224 F227 Y260 I313 A314 E59 W81 Y145 C197 R217 D220 E59 W81 Y145 C197 R217 D220 2.1.1.45 0004799,0005737,0005829,0006231,0006235,0008168,0009165,0016741,0032259 Ki=13uM Q834R3 27517810 402 MEEAYLALGKKILEEGHFKEDRTGTGTYSLFGYQMRFDLAKGFPLLTTKRVPFGLIKSELLWFLKGDTNIRYLLERNNHIWDEWAFERYVKSADYQGPDMTDFGHRVLQDPAFAEQYKEEHQKFCDAILNDAEFAEKYGELGNIYGAQWRHWETKDGSFIDQLANVIEMIKTNPDSRRLIVSAWNPEDVPSMALPPCHTMFQFYVNEGKLSCQLYQRSADVFLGVPFNIASYALLTHLIAHETGLEVGEFVHTLGDAHLYQNHVEQMQEQLSREVRSFPTLVLNPDKASVFDFDMEDIKVEGYDPHPTIKAPIAV 5j7w D 2.5 BS01 MTX D 1 L55 I80 W81 W84 D220 L223 G224 F227 Y260 I313 A314 L55 I80 W81 W84 D220 L223 G224 F227 Y260 I313 A314 E59 W81 Y145 C197 R217 D220 E59 W81 Y145 C197 R217 D220 2.1.1.45 0004799,0005737,0005829,0006231,0006235,0008168,0009165,0016741,0032259 Ki=13uM -logKd/Ki=4.89, Ki=13uM Q834R3 27517810 402 MEEAYLALGKKILEEGHFKEDRTGTGTYSLFGYQMRFDLAKGFPLLTTKRVPFGLIKSELLWFLKGDTNIRYLLERNNHIWDEWAFERYVKSADYQGPDMTDFGHRVLQDPAFAEQYKEEHQKFCDAILNDAEFAEKYGELGNIYGAQWRHWETKDGSFIDQLANVIEMIKTNPDSRRLIVSAWNPEDVPSMALPPCHTMFQFYVNEGKLSCQLYQRSADVFLGVPFNIASYALLTHLIAHETGLEVGEFVHTLGDAHLYQNHVEQMQEQLSREVRSFPTLVLNPDKASVFDFDMEDIKVEGYDPHPTIKAPIAV 5x66 A 1.99 BS02 MTX A 1 R78 F80 I108 D218 F225 Y258 M311 R53 F55 I83 D193 F200 Y233 M286 E87 W109 Y135 C195 R215 D218 E62 W84 Y110 C170 R190 D193 2.1.1.45 0000900,0003729,0004799,0005542,0005634,0005737,0005739,0005743,0005759,0005829,0006206,0006231,0006235,0006417,0007623,0008168,0009165,0009410,0009636,0014070,0016741,0017148,0019860,0032259,0032570,0033189,0034097,0035999,0042803,0045471,0046653,0046683,0048589,0051216,0051384,0051593,0060574,0071897,0097421,1901363,1990825 IC50=29000nM, Ki=600nM P04818 28634233 402 PPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV 5x66 B 1.99 BS02 MTX B 1 F80 I108 D218 G222 F225 Y258 M311 F55 I83 D193 G197 F200 Y233 M286 E87 W109 Y135 C195 R215 D218 E62 W84 Y110 C170 R190 D193 2.1.1.45 0000900,0003729,0004799,0005542,0005634,0005737,0005739,0005743,0005759,0005829,0006206,0006231,0006235,0006417,0007623,0008168,0009165,0009410,0009636,0014070,0016741,0017148,0019860,0032259,0032570,0033189,0034097,0035999,0042803,0045471,0046653,0046683,0048589,0051216,0051384,0051593,0060574,0071897,0097421,1901363,1990825 IC50=29000nM, Ki=600nM P04818 28634233 402 PPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV 5x66 C 1.99 BS02 MTX C 1 I108 F225 Y258 M311 I83 F200 Y233 M286 E87 W109 Y135 C195 R215 D218 E62 W84 Y110 C170 R190 D193 2.1.1.45 0000900,0003729,0004799,0005542,0005634,0005737,0005739,0005743,0005759,0005829,0006206,0006231,0006235,0006417,0007623,0008168,0009165,0009410,0009636,0014070,0016741,0017148,0019860,0032259,0032570,0033189,0034097,0035999,0042803,0045471,0046653,0046683,0048589,0051216,0051384,0051593,0060574,0071897,0097421,1901363,1990825 IC50=29000nM, Ki=600nM P04818 28634233 402 PPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV 5x66 D 1.99 BS03 MTX D 1 R78 F80 I108 D218 G222 F225 Y258 M311 R53 F55 I83 D193 G197 F200 Y233 M286 E87 W109 Y135 C195 R215 D218 E62 W84 Y110 C170 R190 D193 2.1.1.45 0000900,0003729,0004799,0005542,0005634,0005737,0005739,0005743,0005759,0005829,0006206,0006231,0006235,0006417,0007623,0008168,0009165,0009410,0009636,0014070,0016741,0017148,0019860,0032259,0032570,0033189,0034097,0035999,0042803,0045471,0046653,0046683,0048589,0051216,0051384,0051593,0060574,0071897,0097421,1901363,1990825 IC50=29000nM, Ki=600nM P04818 28634233 402 PPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV 5x66 E 1.99 BS03 MTX E 1 F80 K107 I108 D218 F225 Y258 M311 F55 K82 I83 D193 F200 Y233 M286 E87 W109 Y135 C195 R215 D218 E62 W84 Y110 C170 R190 D193 2.1.1.45 0000900,0003729,0004799,0005542,0005634,0005737,0005739,0005743,0005759,0005829,0006206,0006231,0006235,0006417,0007623,0008168,0009165,0009410,0009636,0014070,0016741,0017148,0019860,0032259,0032570,0033189,0034097,0035999,0042803,0045471,0046653,0046683,0048589,0051216,0051384,0051593,0060574,0071897,0097421,1901363,1990825 IC50=29000nM, Ki=600nM P04818 28634233 402 PPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMA 5x66 F 1.99 BS03 MTX F 1 K77 F80 I108 D218 G222 F225 Y258 M311 K52 F55 I83 D193 G197 F200 Y233 M286 E87 W109 Y135 C195 R215 D218 E62 W84 Y110 C170 R190 D193 2.1.1.45 0000900,0003729,0004799,0005542,0005634,0005737,0005739,0005743,0005759,0005829,0006206,0006231,0006235,0006417,0007623,0008168,0009165,0009410,0009636,0014070,0016741,0017148,0019860,0032259,0032570,0033189,0034097,0035999,0042803,0045471,0046653,0046683,0048589,0051216,0051384,0051593,0060574,0071897,0097421,1901363,1990825 IC50=29000nM, Ki=600nM P04818 28634233 402 PPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV 6deb B 1.7 BS01 MTX B 1 L96 D118 T140 I168 V169 L98 D120 T142 I170 V171 S44 K51 Q95 D118 S46 K53 Q97 D120 1.5.1.5,3.5.4.9 0000105,0003824,0004477,0004488,0005829,0006164,0006730,0009086,0016491,0016787,0035999 Q0PA35 302 NAMTLLDGKALSAKIKEELKEKNQFLKSKGIESCLAVILVGDNPASQTYVKSKAKACEECGIKSLVYHLNENITQNELLALINTLNHDDSVHGILVQLPLPDHICKDLILESIISSKDVDGFHPINVGYLNLGLESGFLPCTPLGVMKLLKAYEIDLEGKDAVIIGASNIVGRPMATMLLNAGATVSVCHIKTKDLSLYTRQADLIIVAAGCVNLLRSDMVKEGVIVVDVGINRLESGKIVGDVDFEEVSKKSSYITPVPGGVGPMTIAMLLENTVKSAKNRLN 6deb B 1.7 BS02 MTX B 2 Y47 K51 G209 Y49 K53 G211 S44 K51 Q95 D118 S46 K53 Q97 D120 1.5.1.5,3.5.4.9 0000105,0003824,0004477,0004488,0005829,0006164,0006730,0009086,0016491,0016787,0035999 Q0PA35 303 NAMTLLDGKALSAKIKEELKEKNQFLKSKGIESCLAVILVGDNPASQTYVKSKAKACEECGIKSLVYHLNENITQNELLALINTLNHDDSVHGILVQLPLPDHICKDLILESIISSKDVDGFHPINVGYLNLGLESGFLPCTPLGVMKLLKAYEIDLEGKDAVIIGASNIVGRPMATMLLNAGATVSVCHIKTKDLSLYTRQADLIIVAAGCVNLLRSDMVKEGVIVVDVGINRLESGKIVGDVDFEEVSKKSSYITPVPGGVGPMTIAMLLENTVKSAKNRLN 6ojs A 3.214 BS04 MTX A 1 V9 V10 A11 L25 D32 L33 F36 S37 I62 L67 R70 T134 V7 V8 A9 L23 D30 L31 F34 S35 I60 L65 R68 T132 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E281 W303 Y329 C389 R410 D413 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31172516 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEKKLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6ojs B 3.214 BS04 MTX B 1 V9 V10 A11 L25 D32 L33 F36 S37 I62 L67 R70 T134 V7 V8 A9 L23 D30 L31 F34 S35 I60 L65 R68 T132 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E281 W303 Y329 C389 R410 D413 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31172516 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEKKLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6ojs C 3.214 BS05 MTX C 1 V9 V10 A11 L25 D32 L33 F36 S37 I62 L67 R70 T134 V7 V8 A9 L23 D30 L31 F34 S35 I60 L65 R68 T132 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E281 W303 Y329 C389 R410 D413 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31172516 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEKKLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6ojs D 3.214 BS04 MTX D 1 V9 V10 A11 L25 D32 L33 F36 S37 I62 L67 R70 T134 V7 V8 A9 L23 D30 L31 F34 S35 I60 L65 R68 T132 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E281 W303 Y329 C389 R410 D413 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31172516 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEKKLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6ojs E 3.214 BS05 MTX E 1 V9 V10 A11 L25 D32 L33 F36 S37 I62 L67 R70 T134 V7 V8 A9 L23 D30 L31 F34 S35 I60 L65 R68 T132 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E281 W303 Y329 C389 R410 D413 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31172516 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEKKLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6p9z X 1.86 BS01 MTX X 1 L5 V6 A7 D27 L28 V31 K32 R57 F92 L5 V6 A7 D27 L28 V31 K32 R57 F92 L5 L20 W22 D27 L28 V31 L54 V89 T111 L5 L20 W22 D27 L28 V31 L54 V89 T111 1.5.1.3 0004146,0005829,0006730,0016491,0046452,0046654,0046655,0050661 Ki=0.71nM Ki=1.000000nM P0A017 31565920 201 TLSILVAHDLQRVIGFENQLPWHLPNDLKHVKKLSTGHTLVMGRKTFESIGKPLPNRRNVVLTSDTSFNVEGVDVIHSIEDIYQLPGHVFIFGGQTLFEEMIDKVDDMYITVIEGKFRGDTFFPPYTFEDWEVASSVEGKLDEKNTIPHTFLHLIRK 6pf7 A 2.795 BS04 MTX A 1 V9 V10 A11 D32 L33 F36 S37 I62 L67 R70 V7 V8 A9 D30 L31 F34 S35 I60 L65 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E280 W302 Y328 C388 R409 D412 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEKLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pf7 B 2.795 BS05 MTX B 1 V9 V10 A11 D32 L33 F36 S37 I62 R70 V7 V8 A9 D30 L31 F34 S35 I60 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E280 W302 Y328 C388 R409 D412 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEKLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pf7 C 2.795 BS04 MTX C 1 V9 V10 A11 L25 D32 L33 F36 S37 I62 L67 R70 V7 V8 A9 L23 D30 L31 F34 S35 I60 L65 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E281 W303 Y329 C389 R410 D413 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEKKLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pf7 D 2.795 BS05 MTX D 1 V9 V10 A11 L25 D32 L33 F36 S37 I62 L67 R70 V7 V8 A9 L23 D30 L31 F34 S35 I60 L65 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E280 W302 Y328 C388 R409 D412 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEKLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pf7 E 2.795 BS04 MTX E 1 V9 V10 A11 L25 D32 L33 F36 S37 I62 L67 R70 V7 V8 A9 L23 D30 L31 F34 S35 I60 L65 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E281 W303 Y329 C389 R410 D413 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEKKLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pf8 A 2.533 BS04 MTX A 1 V9 V10 A11 D32 F36 S37 I62 R70 V7 V8 A9 D30 F34 S35 I60 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pf8 B 2.533 BS05 MTX B 1 V9 V10 A11 D32 L33 F36 S37 I62 R70 C113 V7 V8 A9 D30 L31 F34 S35 I60 R68 C111 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pf8 C 2.533 BS04 MTX C 1 V9 V10 A11 D32 F36 S37 I62 R70 V7 V8 A9 D30 F34 S35 I60 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E278 W300 Y326 C386 R407 D410 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pf8 D 2.533 BS05 MTX D 1 V9 V10 A11 L25 D32 F36 S37 I62 R70 C113 V7 V8 A9 L23 D30 F34 S35 I60 R68 C111 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pf8 E 2.533 BS04 MTX E 1 V9 V10 A11 D32 F36 S37 I62 R70 V7 V8 A9 D30 F34 S35 I60 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pf9 A 2.89 BS04 MTX A 1 V9 V10 A11 L25 D32 F36 S37 I62 L67 R70 T134 V7 V8 A9 L23 D30 F34 S35 I60 L65 R68 T132 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pf9 B 2.89 BS04 MTX B 1 V9 V10 A11 L25 D32 F36 S37 I62 L67 R70 T134 V7 V8 A9 L23 D30 F34 S35 I60 L65 R68 T132 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pf9 C 2.89 BS05 MTX C 1 V9 V10 A11 L25 D32 L33 F36 S37 I62 L67 R70 V7 V8 A9 L23 D30 L31 F34 S35 I60 L65 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pf9 D 2.89 BS04 MTX D 1 V9 V10 A11 D32 F36 S37 I62 R70 V7 V8 A9 D30 F34 S35 I60 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pf9 E 2.89 BS04 MTX E 1 V9 V10 A11 L25 D32 L33 F36 S37 I62 R70 V7 V8 A9 L23 D30 L31 F34 S35 I60 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E278 W300 Y326 C386 R407 D410 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pfa A 2.79 BS04 MTX A 1 V9 V10 A11 D32 F36 S37 I62 L67 R70 V7 V8 A9 D30 F34 S35 I60 L65 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pfa B 2.79 BS05 MTX B 1 V9 V10 A11 L25 D32 F36 S37 I62 R70 V7 V8 A9 L23 D30 F34 S35 I60 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pfa C 2.79 BS04 MTX C 1 V9 V10 A11 D32 F36 S37 I62 L67 R70 V7 V8 A9 D30 F34 S35 I60 L65 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E278 W300 Y326 C386 R407 D410 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pfa D 2.79 BS05 MTX D 1 V9 V10 A11 L25 D32 F36 S37 I62 L67 R70 V7 V8 A9 L23 D30 F34 S35 I60 L65 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pfa E 2.79 BS04 MTX E 1 V9 V10 A11 L25 D32 F36 S37 I62 L67 R70 V7 V8 A9 L23 D30 F34 S35 I60 L65 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pfb A 3.089 BS04 MTX A 1 V9 V10 A11 L25 D32 F36 S37 R70 T134 V7 V8 A9 L23 D30 F34 S35 R68 T132 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E278 W300 Y326 C386 R407 D410 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pfb B 3.089 BS05 MTX B 1 V9 V10 A11 D32 L33 F36 S37 I62 R70 V7 V8 A9 D30 L31 F34 S35 I60 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E278 W300 Y326 C386 R407 D410 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pfb C 3.089 BS04 MTX C 1 V9 V10 A11 D32 L33 F36 S37 I62 R70 V7 V8 A9 D30 L31 F34 S35 I60 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pfb D 3.089 BS04 MTX D 1 V9 V10 A11 D32 F36 S37 I62 R70 V7 V8 A9 D30 F34 S35 I60 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pfb E 3.089 BS04 MTX E 1 V9 V10 A11 D32 L33 F36 S37 I62 R70 V7 V8 A9 D30 L31 F34 S35 I60 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E278 W300 Y326 C386 R407 D410 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pfc A 2.689 BS04 MTX A 1 V9 V10 A11 D32 L33 F36 S37 I62 R70 V7 V8 A9 D30 L31 F34 S35 I60 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pfc B 2.689 BS04 MTX B 1 V9 V10 A11 D32 L33 F36 S37 I62 R70 V7 V8 A9 D30 L31 F34 S35 I60 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pfc C 2.689 BS04 MTX C 1 V9 V10 A11 D32 F36 S37 I62 R70 V7 V8 A9 D30 F34 S35 I60 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pfc D 2.689 BS05 MTX D 1 V9 V10 A11 L25 D32 L33 F36 S37 I62 R70 V7 V8 A9 L23 D30 L31 F34 S35 I60 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pfc E 2.689 BS04 MTX E 1 V9 V10 A11 D32 L33 F36 S37 I62 R70 V7 V8 A9 D30 L31 F34 S35 I60 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pfd A 3.324 BS04 MTX A 1 V9 V10 A11 D32 F36 S37 I62 R70 C113 V7 V8 A9 D30 F34 S35 I60 R68 C111 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pfd B 3.324 BS05 MTX B 1 V9 V10 A11 L25 D32 L33 F36 S37 I62 R70 V7 V8 A9 L23 D30 L31 F34 S35 I60 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pfd C 3.324 BS04 MTX C 1 V9 V10 A11 L25 D32 F36 S37 I62 R70 V7 V8 A9 L23 D30 F34 S35 I60 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pfd D 3.324 BS05 MTX D 1 V9 V10 A11 L25 D32 L33 F36 S37 I62 R70 V7 V8 A9 L23 D30 L31 F34 S35 I60 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pfd E 3.324 BS04 MTX E 1 V9 V10 A11 L25 D32 L33 F36 S37 I62 R70 V7 V8 A9 L23 D30 L31 F34 S35 I60 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pfe A 2.812 BS04 MTX A 1 V9 V10 A11 L25 D32 F36 S37 I62 R70 V7 V8 A9 L23 D30 F34 S35 I60 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pfe B 2.812 BS05 MTX B 1 V9 V10 A11 L25 D32 L33 F36 S37 I62 R70 V7 V8 A9 L23 D30 L31 F34 S35 I60 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pfe C 2.812 BS04 MTX C 1 V9 V10 A11 L25 D32 L33 F36 S37 I62 R70 V7 V8 A9 L23 D30 L31 F34 S35 I60 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E281 W303 Y329 C389 R410 D413 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEKKLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pfe D 2.812 BS04 MTX D 1 V9 V10 A11 L25 D32 F36 S37 I62 R70 T134 V7 V8 A9 L23 D30 F34 S35 I60 R68 T132 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E281 W303 Y329 C389 R410 D413 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEKKLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pfe E 2.812 BS05 MTX E 1 V9 V10 A11 L25 D32 L33 F36 S37 I62 R70 V7 V8 A9 L23 D30 L31 F34 S35 I60 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E278 W300 Y326 C386 R407 D410 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pff A 2.982 BS04 MTX A 1 V9 V10 A11 L25 D32 L33 F36 S37 I62 R70 V7 V8 A9 L23 D30 L31 F34 S35 I60 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pff B 2.982 BS05 MTX B 1 V9 V10 A11 L25 D32 L33 K34 F36 S37 I62 R70 V7 V8 A9 L23 D30 L31 K32 F34 S35 I60 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pff C 2.982 BS04 MTX C 1 V9 V10 A11 D32 L33 F36 S37 I62 L67 R70 V7 V8 A9 D30 L31 F34 S35 I60 L65 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pff D 2.982 BS05 MTX D 1 V9 V10 A11 D32 L33 F36 S37 I62 R70 V7 V8 A9 D30 L31 F34 S35 I60 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pff E 2.982 BS04 MTX E 1 V9 V10 A11 L25 D32 L33 F36 S37 I62 R70 V7 V8 A9 L23 D30 L31 F34 S35 I60 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pfg A 2.706 BS04 MTX A 1 V9 V10 A11 L25 D32 L33 F36 S37 I62 R70 C113 V7 V8 A9 L23 D30 L31 F34 S35 I60 R68 C111 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E278 W300 Y326 C386 R407 D410 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pfg B 2.706 BS05 MTX B 1 V9 V10 A11 L25 D32 L33 F36 S37 I62 R70 C113 V7 V8 A9 L23 D30 L31 F34 S35 I60 R68 C111 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pfg C 2.706 BS04 MTX C 1 V9 V10 A11 L25 D32 L33 F36 S37 I62 R70 C113 V7 V8 A9 L23 D30 L31 F34 S35 I60 R68 C111 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pfg D 2.706 BS04 MTX D 1 V9 V10 A11 L25 D32 F36 S37 I62 R70 C113 V7 V8 A9 L23 D30 F34 S35 I60 R68 C111 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pfg E 2.706 BS04 MTX E 1 V9 V10 A11 L25 D32 L33 F36 S37 I62 R70 C113 V7 V8 A9 L23 D30 L31 F34 S35 I60 R68 C111 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pfh A 2.94 BS04 MTX A 1 V9 V10 A11 L25 D32 L33 F36 S37 I62 R70 V7 V8 A9 L23 D30 L31 F34 S35 I60 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E281 W303 Y329 C389 R410 D413 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEKKLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pfh B 2.94 BS05 MTX B 1 V9 V10 A11 D32 L33 F36 S37 I62 R70 V7 V8 A9 D30 L31 F34 S35 I60 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pfh C 2.94 BS04 MTX C 1 V9 V10 A11 L25 D32 L33 F36 S37 I62 R70 V7 V8 A9 L23 D30 L31 F34 S35 I60 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pfh D 2.94 BS04 MTX D 1 V9 V10 A11 L25 D32 L33 F36 S37 I62 R70 V7 V8 A9 L23 D30 L31 F34 S35 I60 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E281 W303 Y329 C389 R410 D413 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEKKLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pfh E 2.94 BS05 MTX E 1 V9 V10 A11 L25 D32 L33 F36 S37 I62 R70 T134 V7 V8 A9 L23 D30 L31 F34 S35 I60 R68 T132 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pfi A 2.89 BS04 MTX A 1 V9 V10 A11 L25 D32 F36 S37 I62 R70 V7 V8 A9 L23 D30 F34 S35 I60 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pfi B 2.89 BS05 MTX B 1 V9 V10 A11 L25 D32 L33 F36 S37 I62 R70 V7 V8 A9 L23 D30 L31 F34 S35 I60 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E280 W302 Y328 C388 R409 D412 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEKLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pfi C 2.89 BS04 MTX C 1 V9 V10 A11 L25 D32 F36 S37 I62 L67 R70 T134 V7 V8 A9 L23 D30 F34 S35 I60 L65 R68 T132 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pfi D 2.89 BS05 MTX D 1 V9 V10 A11 L25 D32 L33 K34 F36 S37 I62 L67 R70 T134 V7 V8 A9 L23 D30 L31 K32 F34 S35 I60 L65 R68 T132 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E280 W302 Y328 C388 R409 D412 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEKLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6pfi E 2.89 BS04 MTX E 1 V9 V10 A11 L25 D32 L33 F36 S37 I62 R70 T134 V7 V8 A9 L23 D30 L31 F34 S35 I60 R68 T132 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E279 W301 Y327 C387 R408 D411 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 31536894 604 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV 6smn A 1.63 BS02 MTX A 1 Y182 T184 T186 I189 Y140 T142 T144 I147 Y102 E104 D257 T283 K286 R292 Y60 E62 D215 T241 K244 R250 2.1.2.1 0004372,0005739,0005747,0006544,0006563,0006730,0008270,0009536,0016740,0019264,0030170,0035999,0050897 Ki=270.2uM Q94C74 31873125 603 SRSSWIKQLNASLDEIDPEVADIIELEKARQWKGFELIPSENFTSLSVMQAVGSVMTNKYSEGYPGARYYGGNEYIDMAETLCQKRALEAFQLDPSKWGVNVQSLSGSPANFQVYTALLKPHERIMALDLPHGGHLSHGYQTDTKKISAVSIFFETMPYRLDENTGYIDYDQLEKSAVLFRPKLIVAGASAYARLYDYARIRKVCNKQKAVMLADMAHISGLVAAGVIPSPFEYADVVTTTTHKSLRGPRGAMIFFRKGLKEINKQGKEVMYDYEDRINQAVFPGLQGGPHNHTITGLAVALKQARTPEYKAYQDQVLRNCSKFAETLLAKGYDLVSGGTDNHLVLVNLKNKGIDGSRVEKVLELVHIAANKNTVPGDVSAMVPGGIRMGTPALTSRGFIEEDFAKVAEYFDLAVKIALKIKAESQGTKLKDFVATMQSNEKLQSEMSKLREMVEEYAKQFPTIGFEKETMRYKE 6smn B 1.63 BS03 MTX B 1 Y182 T184 D185 T186 I189 Y140 T142 D143 T144 I147 Y102 E104 D257 T283 K286 R292 Y60 E62 D215 T241 K244 R250 2.1.2.1 0004372,0005739,0005747,0006544,0006563,0006730,0008270,0009536,0016740,0019264,0030170,0035999,0050897 Ki=270.2uM Q94C74 31873125 2404 SRSSWIKQLNASLDEIDPEVADIIELEKARQWKGFELIPSENFTSLSVMQAVGSVMTNKYSEGYPGARYYGGNEYIDMAETLCQKRALEAFQLDPSKWGVNVQSLSGSPANFQVYTALLKPHERIMALDLPHGGHLSHGYQTDTKKISAVSIFFETMPYRLDENTGYIDYDQLEKSAVLFRPKLIVAGASAYARLYDYARIRKVCNKQKAVMLADMAHISGLVAAGVIPSPFEYADVVTTTTHKSLRGPRGAMIFFRKGLKEINKQGKEVMYDYEDRINQAVFPGLQGGPHNHTITGLAVALKQARTPEYKAYQDQVLRNCSKFAETLLAKGYDLVSGGTDNHLVLVNLKNKGIDGSRVEKVLELVHIAANKNTVPGDVSAMVPGGIRMGTPALTSRGFIEEDFAKVAEYFDLAVKIALKIKAESQGTKLKDFVATMQSNEKLQSEMSKLREMVEEYAKQFPTIGFEKETMRYKE 6smn C 1.63 BS02 MTX C 1 Y182 T184 D185 T186 Y140 T142 D143 T144 Y102 E104 D257 T283 K286 R292 Y60 E62 D215 T241 K244 R250 2.1.2.1 0004372,0005739,0005747,0006544,0006563,0006730,0008270,0009536,0016740,0019264,0030170,0035999,0050897 Ki=270.2uM Q94C74 31873125 603 SRSSWIKQLNASLDEIDPEVADIIELEKARQWKGFELIPSENFTSLSVMQAVGSVMTNKYSEGYPGARYYGGNEYIDMAETLCQKRALEAFQLDPSKWGVNVQSLSGSPANFQVYTALLKPHERIMALDLPHGGHLSHGYQTDTKKISAVSIFFETMPYRLDENTGYIDYDQLEKSAVLFRPKLIVAGASAYARLYDYARIRKVCNKQKAVMLADMAHISGLVAAGVIPSPFEYADVVTTTTHKSLRGPRGAMIFFRKGLKEINKQGKEVMYDYEDRINQAVFPGLQGGPHNHTITGLAVALKQARTPEYKAYQDQVLRNCSKFAETLLAKGYDLVSGGTDNHLVLVNLKNKGIDGSRVEKVLELVHIAANKNTVPGDVSAMVPGGIRMGTPALTSRGFIEEDFAKVAEYFDLAVKIALKIKAESQGTKLKDFVATMQSNEKLQSEMSKLREMVEEYAKQFPTIGFEKETMRYKE 6smn D 1.63 BS02 MTX C 2 Y182 T184 D185 Y145 T147 D148 Y102 E104 D257 T283 K286 R292 Y65 E67 D220 T246 K249 R255 2.1.2.1 0004372,0005739,0005747,0006544,0006563,0006730,0008270,0009536,0016740,0019264,0030170,0035999,0050897 Q94C74 31873125 617 SNAEKSRSSWIKQLNASLDEIDPEVADIIELEKARQWKGFELIPSENFTSLSVMQAVGSVMTNKYSEGYPGARYYGGNEYIDMAETLCQKRALEAFQLDPSKWGVNVQSLSGSPANFQVYTALLKPHERIMALDLPHGGHLSHGYQTDTKKISAVSIFFETMPYRLDENTGYIDYDQLEKSAVLFRPKLIVAGASAYARLYDYARIRKVCNKQKAVMLADMAHISGLVAAGVIPSPFEYADVVTTTTHKSLRGPRGAMIFFRKGLKEINKQGKEVMYDYEDRINQAVFPGLQGGPHNHTITGLAVALKQARTPEYKAYQDQVLRNCSKFAETLLAKGYDLVSGGTDNHLVLVNLKNKGIDGSRVEKVLELVHIAANKNTVPGDVSAMVPGGIRMGTPALTSRGFIEEDFAKVAEYFDLAVKIALKIKAESQGTKLKDFVATMQSNEKLQSEMSKLREMVEEYAKQFPTIGFEKETMRYKE 6smr A 2.12 BS02 MTX B 1 Y139 T141 S142 G143 A382 L383 Y142 T144 S145 G146 A385 L386 Y59 E61 D215 T241 K244 R250 Y62 E64 D218 T244 K247 R253 2.1.2.1 0004372,0005515,0005737,0005829,0005886,0006730,0007623,0009506,0016740,0019264,0030170,0035999,1901149 Ki=179.3uM O23254 31873125 501 SNAMEPVSSWGNTSLVSVDPEIHDLIEKEKRRQCRGIELIASENFTSFAVIEALGSALTNKYSEGIPGNRYYGGNEFIDEIENLCRSRALEAFHCDPAAWGVNVQPYSGSPANFAAYTALLQPHDRIMGLDLPSGGHLTHGYYTSGGKKISATSIYFESLPYKVNFTTGYIDYDKLEEKALDFRPKLLICGGSAYPRDWDYARFRAIADKVGALLLCDMAHISGLVAAQEAANPFEYCDVVTTTTHKSLRGPRAGMIFYRKGPKPPKKGQPEGAVYDFEDKINFAVFPALQGGPHNHQIGALAVALKQANTPGFKVYAKQVKANAVALGNYLMSKGYQIVTNGTENHLVLWDLRPLGLTGNKVEKLCDLCSITLNKNAVFGDSSALAPGGVRIGAPAMTSRGLVEKDFEQIGEFLSRAVTLTLDIQKTYGKLLKDFNKGLVNNKDLDQLKADVEKFSASYEMPGFLMSEMKYK 6smr B 2.12 BS02 MTX A 1 Y139 K373 L383 Y140 K374 L384 Y59 E61 D215 T241 K244 R250 Y60 E62 D216 T242 K245 R251 2.1.2.1 0004372,0005515,0005737,0005829,0005886,0006730,0007623,0009506,0016740,0019264,0030170,0035999,1901149 Ki=179.3uM O23254 31873125 503 AMEPVSSWGNTSLVSVDPEIHDLIEKEKRRQCRGIELIASENFTSFAVIEALGSALTNKYSEGIPGNRYYGGNEFIDEIENLCRSRALEAFHCDPAAWGVNVQPYSGSPANFAAYTALLQPHDRIMGLDLPSGGHLTHGYYTSGGKKISATSIYFESLPYKVNFTTGYIDYDKLEEKALDFRPKLLICGGSAYPRDWDYARFRAIADKVGALLLCDMAHISGLVAAQEAANPFEYCDVVTTTTHKSLRGPRAGMIFYRKGPKPPKKGQPEGAVYDFEDKINFAVFPALQGGPHNHQIGALAVALKQANTPGFKVYAKQVKANAVALGNYLMSKGYQIVTNGTENHLVLWDLRPLGLTGNKVEKLCDLCSITLNKNAVFGDSSALAPGGVRIGAPAMTSRGLVEKDFEQIGEFLSRAVTLTLDIQKTYGKLLKDFNKGLVNNKDLDQLKADVEKFSASYEMPGFLMSEMKYKD 6smr B 2.12 BS03 MTX B 1 Y68 P285 Y69 P286 Y59 E61 D215 T241 K244 R250 Y60 E62 D216 T242 K245 R251 2.1.2.1 0004372,0005515,0005737,0005829,0005886,0006730,0007623,0009506,0016740,0019264,0030170,0035999,1901149 Ki=179.3uM O23254 31873125 501 AMEPVSSWGNTSLVSVDPEIHDLIEKEKRRQCRGIELIASENFTSFAVIEALGSALTNKYSEGIPGNRYYGGNEFIDEIENLCRSRALEAFHCDPAAWGVNVQPYSGSPANFAAYTALLQPHDRIMGLDLPSGGHLTHGYYTSGGKKISATSIYFESLPYKVNFTTGYIDYDKLEEKALDFRPKLLICGGSAYPRDWDYARFRAIADKVGALLLCDMAHISGLVAAQEAANPFEYCDVVTTTTHKSLRGPRAGMIFYRKGPKPPKKGQPEGAVYDFEDKINFAVFPALQGGPHNHQIGALAVALKQANTPGFKVYAKQVKANAVALGNYLMSKGYQIVTNGTENHLVLWDLRPLGLTGNKVEKLCDLCSITLNKNAVFGDSSALAPGGVRIGAPAMTSRGLVEKDFEQIGEFLSRAVTLTLDIQKTYGKLLKDFNKGLVNNKDLDQLKADVEKFSASYEMPGFLMSEMKYKD 6smr D 2.12 BS03 MTX D 1 T141 S142 K373 S381 A382 L383 T142 S143 K374 S382 A383 L384 Y59 E61 D215 T241 K244 R250 Y60 E62 D216 T242 K245 R251 2.1.2.1 0004372,0005515,0005737,0005829,0005886,0006730,0007623,0009506,0016740,0019264,0030170,0035999,1901149 Ki=179.3uM O23254 31873125 703 AMEPVSSWGNTSLVSVDPEIHDLIEKEKRRQCRGIELIASENFTSFAVIEALGSALTNKYSEGIPGNRYYGGNEFIDEIENLCRSRALEAFHCDPAAWGVNVQPYSGSPANFAAYTALLQPHDRIMGLDLPSGGHLTHGYYTSGGKKISATSIYFESLPYKVNFTTGYIDYDKLEEKALDFRPKLLICGGSAYPRDWDYARFRAIADKVGALLLCDMAHISGLVAAQEAANPFEYCDVVTTTTHKSLRGPRAGMIFYRKGPKPPKKGQPEGAVYDFEDKINFAVFPALQGGPHNHQIGALAVALKQANTPGFKVYAKQVKANAVALGNYLMSKGYQIVTNGTENHLVLWDLRPLGLTGNKVEKLCDLCSITLNKNAVFGDSSALAPGGVRIGAPAMTSRGLVEKDFEQIGEFLSRAVTLTLDIQKTYGKLLKDFNKGLVNNKDLDQLKADVEKFSASYEMPGFLMSEMKYK 6uy3 A 2.0 BS01 MTX A 1 V2 A24 R26 S28 S29 R30 W32 R72 Y77 L78 V79 V1 A23 R25 S27 S28 R29 W31 R71 Y76 L77 V78 33514714 306 VQLVESGGGLVQAGGSLRLSCAASRRSSRSWAMHWVRQAPGKGLEWVAVISYDGRLKYYADSVKGRFTISRDNAEYLVYLQMNSLRAEDTAVYYCAAEEGDGGFFDYWGQGTLVTVSSGSVLTQPPSASGTPGQRVTISCSGSSSNIGSNYVNWYQQLPGTAPKLLIYRNNERPSGVPDRFSGSKSGTSASLAISGLRSEDEADYYCAAWDGSLSGRGVFGTGTKLTVLENLYFQG 6wep A 2.79 BS02 MTX A 1 V9 V10 A11 L25 D32 L33 F36 S37 I62 L67 R70 V7 V8 A9 L23 D30 L31 F34 S35 I60 L65 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E278 W300 Y326 C386 R407 D410 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 602 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDM 6wep B 2.79 BS02 MTX B 1 V9 V10 A11 L25 D32 L33 F36 S37 I62 L67 R70 V7 V8 A9 L23 D30 L31 F34 S35 I60 L65 R68 L25 D32 E294 W316 Y342 C402 R423 D426 L23 D30 E278 W300 Y326 C386 R407 D410 1.5.1.3,2.1.1.45 0000166,0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 A0A0S4TER9 602 EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDM 7cca A 2.75 BS02 MTX A 1 H82 I83 F200 Y233 K286 H82 I83 F200 Y233 K286 E62 W84 Y110 C170 R190 D193 E62 W84 Y110 C170 R190 D193 2.1.1.45 0004799,0005829,0006231,0008168,0009165,0016741,0032259 Q77J90 33197475 302 MEGEHQYLNLVREILERGVKKDDRTGTGTLSIFGPQMRFSLRDDTIPVLTTKKIFWRGVVEELLWFIRGNTDAKELAKKKIHIWNANGSREFLDSRGLYDRAEGDLGPVYGFQWRHFGAEYDTCSSDYTGKGIDQLANILKTLRENPDDRRMIMTAWNPMDLHLMALPPCHMTAQFYVANGELSCQLYQRSGDVGLGVPFNIASYSLLTHLMASMVGLKPGEFILTLGDAHIYNTHIEVLKKQLCRVPRPFPKLRILMAPEKIEDFTIDMFYLEGYQPHSGNLQMKMAV 7cca B 2.75 BS03 MTX B 1 F55 I81 H82 I83 F200 K286 F55 I81 H82 I83 F200 K286 E62 W84 Y110 C170 R190 D193 E62 W84 Y110 C170 R190 D193 2.1.1.45 0004799,0005829,0006231,0008168,0009165,0016741,0032259 Q77J90 33197475 302 MEGEHQYLNLVREILERGVKKDDRTGTGTLSIFGPQMRFSLRDDTIPVLTTKKIFWRGVVEELLWFIRGNTDAKELAKKKIHIWNANGSREFLDSRGLYDRAEGDLGPVYGFQWRHFGAEYDTCSSDYTGKGIDQLANILKTLRENPDDRRMIMTAWNPMDLHLMALPPCHMTAQFYVANGELSCQLYQRSGDVGLGVPFNIASYSLLTHLMASMVGLKPGEFILTLGDAHIYNTHIEVLKKQLCRVPRPFPKLRILMAPEKIEDFTIDMFYLEGYQPHSGNLQMKM 7dp4 A 1.5 BS02 MTX A 1 Y73 I101 W102 L214 F218 M304 Y56 I84 W85 L197 F201 M287 2.1.1.45 0004799,0005739,0005829,0006231,0006235,0008168,0009165,0016741,0032259 A0A4E9EZW9 402 KNEDESKYLDQVRYILKNGERIDDRTGVGTISVFGMHSVYSLRNGVVPVLTTKRVYWKGVVEELLWFIRGDTNAKHLSEKGVRIWDANGSRQFLDQCGFSDRSEGDLGPIYGFQWRHCGAEYRGMDTDYTNQGIDQLSEIIDLIKNEPHSRRIILSAWNVKDLKLMALPPCHTLAQFAVRNGELSCQLYQRSGDMGLGVPFNLASYGLLTHMIAHVCGLKTGHLCHVLGDAHVYMNHVDALQEQLKRQPRQFPTVRFIGNIKTIDDFTYESIVLENYQPMPAIKMAM 7dp5 A 1.6 BS02 MTX A 1 Y73 I101 L214 F218 M302 M304 Y56 I84 L197 F201 M285 M287 2.1.1.45 0004799,0005739,0005829,0006231,0006235,0008168,0009165,0016741,0032259 A0A4E9EZW9 402 KNEDESKYLDQVRYILKNGERIDDRTGAGTISVFGMHSVYSLRNGVVPVLTTKRVYWKGVVEELLWFIRGDTNAKHLSEKGVRIWDANGSRQFLDQCGFSDRSEGDLGPIYGFQWRHCGAEYRGMDTDYTNQGIDQLSEIIDLIKNEPHSRRIILSAWNVKDLKLMALPPCHTLAQFAVRNGELSCQLYQRSGDMGLGVPFNLASYGLLTHMIAHVCGLKTGHLCHVLGDAHVYMNHVDALQEQLKRQPRQFPTVRFIGNIKTIDDFTYESIVLENYQPMPAIKMAM 7f3y A 2.252 BS02 MTX A 1 I14 C15 A16 D54 M55 F58 I112 F116 L119 R122 I164 I14 C15 A16 D54 M55 F58 I102 F106 L109 R112 I154 1.5.1.3,2.1.1.45 0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 IC50=84nM P13922 34614393 702 MMEQVCDVFDIYAICACCKVESKNEGKKNEVFNNYTFRGLGNKGVLPWKCNSLDMKYFCAVTTYVNESKYEKLKYKRCKYLNKETKKLQNVVVMGRTSWESIPKKFKPLSNRINVILSRTLKKEDFDEDVYIINKVEDLIVLLGKLNYYKCFIIGGSVVYQEFLEKKLIKKIYFTRINSTYECDVFFPEINENEYQIISVSDVYTSNNTTLDFIIYKKTNNDDEEEDDFVYFNFNKEKEEKNKNSIHPNDFQIYNSLKYKYHPEYQYLNIIYDIMMNGNKQSDRTGVGVLSKFGYIMKFDLSQYFPLLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMYDNYENKGVDQLKNIINLIKNDPTSRRILLCAWNVKDLDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHVLGNAHVYNNHIDSLKIQLNRIPYPFPTLKLNPDIKNIEDFTISDFTIQNYVHHEKISMDMAA 7f3y A 2.252 BS04 MTX A 2 D513 L516 G517 F520 Y553 I602 S603 D452 L455 G456 F459 Y492 I541 S542 1.5.1.3,2.1.1.45 0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 IC50=84nM P13922 34614393 704 MMEQVCDVFDIYAICACCKVESKNEGKKNEVFNNYTFRGLGNKGVLPWKCNSLDMKYFCAVTTYVNESKYEKLKYKRCKYLNKETKKLQNVVVMGRTSWESIPKKFKPLSNRINVILSRTLKKEDFDEDVYIINKVEDLIVLLGKLNYYKCFIIGGSVVYQEFLEKKLIKKIYFTRINSTYECDVFFPEINENEYQIISVSDVYTSNNTTLDFIIYKKTNNDDEEEDDFVYFNFNKEKEEKNKNSIHPNDFQIYNSLKYKYHPEYQYLNIIYDIMMNGNKQSDRTGVGVLSKFGYIMKFDLSQYFPLLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMYDNYENKGVDQLKNIINLIKNDPTSRRILLCAWNVKDLDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHVLGNAHVYNNHIDSLKIQLNRIPYPFPTLKLNPDIKNIEDFTISDFTIQNYVHHEKISMDMAA 7f3y B 2.252 BS03 MTX B 1 I14 C15 A16 L46 D54 M55 F58 F116 R122 I164 I14 C15 A16 L46 D54 M55 F58 F106 R112 I154 1.5.1.3,2.1.1.45 0004146,0004799,0005739,0005829,0006231,0006730,0008168,0009165,0016491,0016741,0032259,0046654 IC50=84nM P13922 34614393 702 MMEQVCDVFDIYAICACCKVESKNEGKKNEVFNNYTFRGLGNKGVLPWKCNSLDMKYFCAVTTYVNESKYEKLKYKRCKYLNKETKKLQNVVVMGRTSWESIPKKFKPLSNRINVILSRTLKKEDFDEDVYIINKVEDLIVLLGKLNYYKCFIIGGSVVYQEFLEKKLIKKIYFTRINSTYECDVFFPEINENEYQIISVSDVYTSNNTTLDFIIYKKTNNDEEEDDFVYFNFNKEKEEKNKNSIHPNDFQIYNSLKYKYHPEYQYLNIIYDIMMNGNKQSDRTGVGVLSKFGYIMKFDLSQYFPLLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMYDNYENKGVDQLKNIINLIKNDPTSRRILLCAWNVKDLDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHVLGNAHVYNNHIDSLKIQLNRIPYPFPTLKLNPDIKNIEDFTISDFTIQNYVHHEKISMDMAA 7rg7 A 1.83 BS01 MTX A 1 V176 A198 R200 R201 S202 S203 R204 W206 R246 N248 Y251 L252 V253 V142 A164 R166 R167 S168 S169 R170 W172 R212 N214 Y217 L218 V219 34880210 301 NPSLIRSESWSVASGNEANLLDGDDNTGVWYKNHHHWESLAGEFIGLDLGKEIKLDGIRFVIGKNGGGSSDKWNKFKLEYSLDNESWTTIKEYDKTGAPAGKDVIEESFETPISAKYIRLTNLEAAPAHLTFSEFAIVSDQVQLVESGGGLVQAGGSLRLSCAASRRSSRSWAMAWFRQAPGKEREFVAKISGDGRLTTYGDSVKGRFTISRDNAEYLVYLQMDSLKPEDTAVYYCAADDNYVTASWRSGPDYWGQGTQVTVSS 7rga A 2.9 BS01 MTX A 1 R200 S202 M208 R246 Y251 L252 V253 R167 S169 M175 R213 Y218 L219 V220 3.2.1.35 P26831 34880210 301 NPSLIRSESWHVYDGNEANLLDGDDNTGVWYKRSNGEASLAGEFIGLDLGKEIKLDGIRFVIGKNGGGSSDKWNKFKLEYSLDNESWTTIKEYDKTGAPAGKDVIEESFETPISAKYIRLTNLEPRHVQLTFSEFAIVSDSQVQLVESGGGLVQAGGSLRLSCAASRRSSRSWAMAWFRQAPGKEREFVAKISGDGRLTTYGDSVKGRFTISRDNAEYLVYLQMDSLKPEDTAVYYCAADDNYVTASWRSGPDYWGQGTQVTVSS 7rga A 2.9 BS02 MTX B 1 G97 A98 P99 G97 A98 P99 3.2.1.35 P26831 34880210 301 NPSLIRSESWHVYDGNEANLLDGDDNTGVWYKRSNGEASLAGEFIGLDLGKEIKLDGIRFVIGKNGGGSSDKWNKFKLEYSLDNESWTTIKEYDKTGAPAGKDVIEESFETPISAKYIRLTNLEPRHVQLTFSEFAIVSDSQVQLVESGGGLVQAGGSLRLSCAASRRSSRSWAMAWFRQAPGKEREFVAKISGDGRLTTYGDSVKGRFTISRDNAEYLVYLQMDSLKPEDTAVYYCAADDNYVTASWRSGPDYWGQGTQVTVSS 7rga B 2.9 BS01 MTX A 1 G97 A98 P99 G97 A98 P99 3.2.1.35 P26831 34880210 301 NPSLIRSESWHVYDGNEANLLDGDDNTGVWYKRSNGEASLAGEFIGLDLGKEIKLDGIRFVIGKNGGGSSDKWNKFKLEYSLDNESWTTIKEYDKTGAPAGKDVIEESFETPISAKYIRLTNLEPRHVQLTFSEFAIVSDSQVQLVESGGGLVQAGGSLRLSCAASRRSSRSWAMAWFRQAPGKEREFVAKISGDGRLTTYGDSVKGRFTISRDNAEYLVYLQMDSLKPEDTAVYYCAADDNYVTASWRSGPDYWGQGTQVTVSS 7rga B 2.9 BS02 MTX B 1 A198 R200 S202 W206 M208 R246 N248 Y251 L252 V253 A165 R167 S169 W173 M175 R213 N215 Y218 L219 V220 3.2.1.35 P26831 34880210 301 NPSLIRSESWHVYDGNEANLLDGDDNTGVWYKRSNGEASLAGEFIGLDLGKEIKLDGIRFVIGKNGGGSSDKWNKFKLEYSLDNESWTTIKEYDKTGAPAGKDVIEESFETPISAKYIRLTNLEPRHVQLTFSEFAIVSDSQVQLVESGGGLVQAGGSLRLSCAASRRSSRSWAMAWFRQAPGKEREFVAKISGDGRLTTYGDSVKGRFTISRDNAEYLVYLQMDSLKPEDTAVYYCAADDNYVTASWRSGPDYWGQGTQVTVSS 7rga C 2.9 BS01 MTX C 1 A198 R200 S202 W206 M208 R246 Y251 L252 V253 Y287 A165 R167 S169 W173 M175 R213 Y218 L219 V220 Y254 3.2.1.35 P26831 34880210 301 NPSLIRSESWHVYDGNEANLLDGDDNTGVWYKRSNGEASLAGEFIGLDLGKEIKLDGIRFVIGKNGGGSSDKWNKFKLEYSLDNESWTTIKEYDKTGAPAGKDVIEESFETPISAKYIRLTNLEPRHVQLTFSEFAIVSDSQVQLVESGGGLVQAGGSLRLSCAASRRSSRSWAMAWFRQAPGKEREFVAKISGDGRLTTYGDSVKGRFTISRDNAEYLVYLQMDSLKPEDTAVYYCAADDNYVTASWRSGPDYWGQGTQVTVSS 7rga D 2.9 BS01 MTX D 1 V176 R200 S202 M208 R246 Y251 L252 V143 R167 S169 M175 R213 Y218 L219 3.2.1.35 P26831 34880210 301 NPSLIRSESWHVYDGNEANLLDGDDNTGVWYKRSNGEASLAGEFIGLDLGKEIKLDGIRFVIGKNGGGSSDKWNKFKLEYSLDNESWTTIKEYDKTGAPAGKDVIEESFETPISAKYIRLTNLEPRHVQLTFSEFAIVSDSQVQLVESGGGLVQAGGSLRLSCAASRRSSRSWAMAWFRQAPGKEREFVAKISGDGRLTTYGDSVKGRFTISRDNAEYLVYLQMDSLKPEDTAVYYCAADDNYVTASWRSGPDYWGQGTQVTVSS 7rga E 2.9 BS01 MTX E 1 L178 S202 M208 R246 D247 Y251 L252 V253 Y287 L150 S174 M180 R218 D219 Y223 L224 V225 Y259 3.2.1.35 P26831 34880210 301 HHHHSNPSLIRSESWHVYDGNEANLLDGDDNTGVWYKRSNGEASLAGEFIGLDLGKEIKLDGIRFVIGKNGGGSSDKWNKFKLEYSLDNESWTTIKEYDKTGAPAGKDVIEESFETPISAKYIRLTNLEPRHVQLTFSEFAIVSDSQVQLVESGGGLVQAGGSLRLSCAASRRSSRSWAMAWFRQAPGKEREFVAKISGDGRLTTYGDSVKGRFTISRDNAEYLVYLQMDSLKPEDTAVYYCAADDNYVTASWRSGPDYWGQGTQVTVSS 7rga E 2.9 BS02 MTX G 1 T96 G97 A98 P99 T101 G102 A103 P104 3.2.1.35 P26831 34880210 301 HHHHSNPSLIRSESWHVYDGNEANLLDGDDNTGVWYKRSNGEASLAGEFIGLDLGKEIKLDGIRFVIGKNGGGSSDKWNKFKLEYSLDNESWTTIKEYDKTGAPAGKDVIEESFETPISAKYIRLTNLEPRHVQLTFSEFAIVSDSQVQLVESGGGLVQAGGSLRLSCAASRRSSRSWAMAWFRQAPGKEREFVAKISGDGRLTTYGDSVKGRFTISRDNAEYLVYLQMDSLKPEDTAVYYCAADDNYVTASWRSGPDYWGQGTQVTVSS 7rga F 2.9 BS01 MTX F 1 A198 R201 S202 W206 M208 Y251 L252 V253 A165 R168 S169 W173 M175 Y218 L219 V220 3.2.1.35 P26831 34880210 301 NPSLIRSESWHVYDGNEANLLDGDDNTGVWYKRSNGEASLAGEFIGLDLGKEIKLDGIRFVIGKNGGGSSDKWNKFKLEYSLDNESWTTIKEYDKTGAPAGKDVIEESFETPISAKYIRLTNLEPRHVQLTFSEFAIVSDSQVQLVESGGGLVQAGGSLRLSCAASRRSSRSWAMAWFRQAPGKEREFVAKISGDGRLTTYGDSVKGRFTISRDNAEYLVYLQMDSLKPEDTAVYYCAADDNYVTASWRSGPDYWGQGTQVTVSS 7rga G 2.9 BS01 MTX E 1 G97 A98 P99 G97 A98 P99 3.2.1.35 P26831 34880210 301 NPSLIRSESWHVYDGNEANLLDGDDNTGVWYKRSNGEASLAGEFIGLDLGKEIKLDGIRFVIGKNGGGSSDKWNKFKLEYSLDNESWTTIKEYDKTGAPAGKDVIEESFETPISAKYIRLTNLEPRHVQLTFSEFAIVSDSQVQLVESGGGLVQAGGSLRLSCAASRRSSRSWAMAWFRQAPGKEREFVAKISGDGRLTTYGDSVKGRFTISRDNAEYLVYLQMDSLKPEDTAVYYCAADDNYVTASWRSGPDYWGQGTQVTVSS 7rga G 2.9 BS02 MTX G 1 Q175 R200 S202 W206 R246 Y251 L252 Y287 Q142 R167 S169 W173 R213 Y218 L219 Y254 3.2.1.35 P26831 34880210 301 NPSLIRSESWHVYDGNEANLLDGDDNTGVWYKRSNGEASLAGEFIGLDLGKEIKLDGIRFVIGKNGGGSSDKWNKFKLEYSLDNESWTTIKEYDKTGAPAGKDVIEESFETPISAKYIRLTNLEPRHVQLTFSEFAIVSDSQVQLVESGGGLVQAGGSLRLSCAASRRSSRSWAMAWFRQAPGKEREFVAKISGDGRLTTYGDSVKGRFTISRDNAEYLVYLQMDSLKPEDTAVYYCAADDNYVTASWRSGPDYWGQGTQVTVSS 7tx6 A 3.3 BS01 MTX A 1 I48 T49 Y76 E123 Y126 M130 R133 Y282 Y286 K411 I26 T27 Y54 E101 Y104 M108 R111 Y221 Y225 K350 ? 0005506,0005886,0008518,0009055,0015350,0015884,0016020,0020037,0022900,0042597,0046872,0051180,0051958,0090482 P0ABE7,P41440 36071163 2644 RSWRHLVCYLCFYGFMAQIRPGESFITPYLLGPDKNFTREQVTNEITPVLSYSYLAVLVPVFLLTDYLRYTPVLLLQGLSFVSVWLLLLLGHSVAHMQLMELFYSVTMAARIAYSSYIFSLVRPARYQRVAGYSRAAVLLGVFTSSVLGQLLVTVGRVSFSTLNYISLAFLTFSVVLALFLKRPKRSLFLARMLRELGDSLRRPQLRLWSLWWVFNSAGYYLVVYYVHILWNEVDPTTNSARVYNGAADAASTLLGAITSFAAGFVKIRWARWSKLLIAGVTATQAGLVFLLAHTRHPSSIWLCYAAFVLFRGSYQFLVPIATFQIASSLSKELCALVFGVNTFFATIVKTIITFIVSDVRGLGLPVRKQFQLYSVYFLILSIIYFLGAMLDGLRHCQ 8bwp A 3.6 BS01 MTX A 1 F324 L363 T366 L367 F368 W995 F318 L357 T360 L361 F362 W896 7.6.2.-,7.6.2.2,7.6.2.3 0001409,0002576,0005515,0005524,0005730,0005794,0005886,0006805,0006855,0006869,0008559,0015132,0015143,0015216,0015431,0015432,0015562,0015721,0015732,0015747,0016020,0016323,0016324,0016404,0016887,0031088,0032310,0034634,0034775,0042626,0042910,0043225,0055085,0060271,0070730,0071716,0098591,0098656,0140115,0140359,0150104,1903790 O15439 37683641 1401 EVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLNEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQQLGKAEAAALTETAKQVYFK 8xom A 3.05 BS02 MTX A 1 L321 F324 L367 D842 W995 L315 F318 L361 D762 W915 0001409,0002576,0005515,0005524,0005730,0005794,0005886,0006805,0006855,0006869,0008559,0015132,0015143,0015216,0015431,0015432,0015562,0015721,0015732,0015747,0016020,0016323,0016324,0016404,0031088,0032310,0034634,0034775,0042626,0042910,0043225,0055085,0060271,0070730,0071716,0098591,0098656,0140115,0140359,0150104,1903790 O15439 38886124 1402 EVKPNPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQQLG