1el9 A 2.0 BS02 MTG A 1 I50 R52 M245 Y254 H269 G344 K348 I50 R52 M245 Y254 H269 G344 K348 H45 T48 R49 R52 S98 Y254 K265 H269 C315 H345 K348 H45 T48 R49 R52 S98 Y254 K265 H269 C315 H345 K348 1.5.3.1 0005737,0005829,0008115,0016491,0050660 Kd=2.6mM P40859 10913292 801 STHFDVIVVGAGSMGMAAGYQLAKQGVKTLLVDAFDPPHTNGSHHGDTRIIRHAYGEGREYVPLALRSQELWYELEKETHHKIFTKTGVLVFGPKGESAFVAETMEAAKEHSLTVDLLEGDEINKRWPGITVPENYNAIFEPNSGVLFSENCIRAYRELAEARGAKVLTHTRVEDFDISPDSVKIETANGSYTADKLIVSMGAWNSKLLSKLNLDIPLQPYRQVVGFFESDESKYSNDIDFPGFMVEVPNGIYYGFPSFGGCGLKLGYHTFGQKIDPDTINREFGVYPEDESNLRAFLEEYMPGANGELKRGAVCMYTKTLDEHFIIDLHPEHSNVVIAAGFSGHGFKFSSGVGEVLSQLALTGKTEHDISIFSINRPALKESLQ 1el9 B 2.0 BS02 MTG B 1 I50 R52 M245 Y254 H269 G344 K348 I50 R52 M245 Y254 H269 G344 K348 H45 T48 R49 R52 S98 Y254 K265 H269 C315 H345 K348 H45 T48 R49 R52 S98 Y254 K265 H269 C315 H345 K348 1.5.3.1 0005737,0005829,0008115,0016491,0050660 Kd=2.6mM P40859 10913292 811 STHFDVIVVGAGSMGMAAGYQLAKQGVKTLLVDAFDPPHTNGSHHGDTRIIRHAYGEGREYVPLALRSQELWYELEKETHHKIFTKTGVLVFGPKGESAFVAETMEAAKEHSLTVDLLEGDEINKRWPGITVPENYNAIFEPNSGVLFSENCIRAYRELAEARGAKVLTHTRVEDFDISPDSVKIETANGSYTADKLIVSMGAWNSKLLSKLNLDIPLQPYRQVVGFFESDESKYSNDIDFPGFMVEVPNGIYYGFPSFGGCGLKLGYHTFGQKIDPDTINREFGVYPEDESNLRAFLEEYMPGANGELKRGAVCMYTKTLDEHFIIDLHPEHSNVVIAAGFSGHGFKFSSGVGEVLSQLALTGKTEHDISIFSINRPALKESLQ 3ad7 B 2.2 BS03 MTG B 1 I67 R69 M264 Y271 T354 K358 V402 I67 R69 M264 Y271 T354 K358 V402 A62 T65 T66 G326 K358 A62 T65 T66 G326 K358 1.5.3.24 0000166,0005737,0008115,0016491,0046653 Kd=3.01mM -logKd/Ki=2.52, Kd=3.01mM Q50LF2 20675294 801 ADLLPEHPEFLWNNPEPKKSYDVVIVGGGGHGLATAYYLAKNHGITNVAVLEKGWLAGGNMARNTTIIRSNYLWDESAGIYEKSLKLWEELPEELEYDFLFSQRGVLNLAHTLGDVRESIRRVEANKFNGVDAEWLTPEQVKEVCPIINTGDNIRYPVMGATYQPRAGIAKHDHVAWAFARKANEMGVDIIQNCEVTGFLKDGEKVTGVKTTRGTILAGKVALAGAGHSSVLAELAGFELPIQSHPLQALVSELFEPVHPTVVMSNHIHVYVSQAHKGELVMGAGIDSYNGYGQRGAFHVIEEQMAAAVELFPIFARAHVLRTWGGIVDTTMDASPIISKTPIQNLYVNCGWGTGGFKGTPGAGYTLAHTIAHDEPHKLNAPFALERFETGHLIDEHGAAAVAH 3qss A 1.85 BS04 MTG A 1 I50 R52 M245 Y254 H269 G344 K348 I50 R52 M245 Y254 H269 G344 K348 H45 T48 R49 R52 S98 Y254 K265 H269 C315 H345 K348 H45 T48 R49 R52 S98 Y254 K265 H269 C315 H345 K348 1.5.3.1 0005737,0005829,0008115,0016491,0050660 Kd=4.9mM P40859 21568312 405 STHFDVIVVGAGSMGMAAGYQLAKQGVKTLLVDAFDPPHTNGSHHGDTRIIRHAYGEGREYVPLALRSQELWYELEKETHHKIFTKTGVLVFGPKGESAFVAETMEAAKEHSLTVDLLEGDEINKRWPGITVPENYNAIFEPNSGVLFSENCIRAYRELAEARGAKVLTHTRVEDFDISPDSVKIETANGSYTADKLIVSMGAWNSKLLSKLNLDIPLQPYRQVVGFFESDESKYSNDIDFPGFMVEVPNGIYYGFPSFGGCGLKLGYHTFGQKIDPDTINREFGVYPEDESNLRAFLEEYMPGANGELKRGAVCMYTKTLDEHFIIDLHPEHSNVVIAAGFSGHGFKFSSGVGEVLSQLALTGKTEHDISIFSINRPALKES 3qss B 1.85 BS04 MTG B 1 I50 R52 M245 Y254 H269 G344 K348 I50 R52 M245 Y254 H269 G344 K348 H45 T48 R49 R52 S98 Y254 K265 H269 C315 H345 K348 H45 T48 R49 R52 S98 Y254 K265 H269 C315 H345 K348 1.5.3.1 0005737,0005829,0008115,0016491,0050660 Kd=4.9mM P40859 21568312 405 STHFDVIVVGAGSMGMAAGYQLAKQGVKTLLVDAFDPPHTNGSHHGDTRIIRHAYGEGREYVPLALRSQELWYELEKETHHKIFTKTGVLVFGPKGESAFVAETMEAAKEHSLTVDLLEGDEINKRWPGITVPENYNAIFEPNSGVLFSENCIRAYRELAEARGAKVLTHTRVEDFDISPDSVKIETANGSYTADKLIVSMGAWNSKLLSKLNLDIPLQPYRQVVGFFESDESKYSNDIDFPGFMVEVPNGIYYGFPSFGGCGLKLGYHTFGQKIDPDTINREFGVYPEDESNLRAFLEEYMPGANGELKRGAVCMYTKTLDEHFIIDLHPEHSNVVIAAGFSGHGFKFSSGVGEVLSQLALTGKTEHDISIFSINRPALKES 8td6 B 2.08 BS01 MTG A 1 G175 S176 G181 S182 0004735,0005515,0005739,0005759,0006561,0016491,0034599,0042802,0051881,0055129,1903377 P32322 39133178 402 NLYFQSMSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKMGVKLTPHNKETVQHSDVLFLAVKPHIIPFILDEIGADIEDRHIVVSCAAGVTISSIEKKLSAFRPAPRVIRCMTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSSVGFCTEVEEDLIDAVTGLSGSGPAYAFTALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLHSEQHPGQLKDNVSSPGGATIHALHVLESGGFRSLLINAVEASCIRTRELQSMADQE 8td6 C 2.08 BS02 MTG C 1 A237 T238 A237 T238 0004735,0005515,0005739,0005759,0006561,0016491,0034599,0042802,0051881,0055129,1903377 P32322 39133178 402 MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKMGVKLTPHNKETVQHSDVLFLAVKPHIIPFILDEIGADIEDRHIVVSCAAGVTISSIEKKLSAFRPAPRVIRCMTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSSVGFCTEVEEDLIDAVTGLSGSGPAYAFTALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLHSEQHPGQLKDNVSSPGGATIHALHVLESGGFRSLLINAVEASCIRTRELQSMADQE 8td6 C 2.08 BS03 MTG D 1 G175 S176 G175 S176 0004735,0005515,0005739,0005759,0006561,0016491,0034599,0042802,0051881,0055129,1903377 P32322 39133178 402 MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKMGVKLTPHNKETVQHSDVLFLAVKPHIIPFILDEIGADIEDRHIVVSCAAGVTISSIEKKLSAFRPAPRVIRCMTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSSVGFCTEVEEDLIDAVTGLSGSGPAYAFTALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLHSEQHPGQLKDNVSSPGGATIHALHVLESGGFRSLLINAVEASCIRTRELQSMADQE 8td6 D 2.08 BS01 MTG C 1 T171 G175 S176 T177 G181 S182 0004735,0005515,0005739,0005759,0006561,0016491,0034599,0042802,0051881,0055129,1903377 P32322 39133178 402 NLYFQSMSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKMGVKLTPHNKETVQHSDVLFLAVKPHIIPFILDEIGADIEDRHIVVSCAAGVTISSIEKKLSAFRPAPRVIRCMTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSSVGFCTEVEEDLIDAVTGLSGSGPAYAFTALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLHSEQHPGQLKDNVSSPGGATIHALHVLESGGFRSLLINAVEASCIRTRELQSMAD 8td6 D 2.08 BS03 MTG D 1 S233 T238 S239 T244 0004735,0005515,0005739,0005759,0006561,0016491,0034599,0042802,0051881,0055129,1903377 P32322 39133178 402 NLYFQSMSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKMGVKLTPHNKETVQHSDVLFLAVKPHIIPFILDEIGADIEDRHIVVSCAAGVTISSIEKKLSAFRPAPRVIRCMTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSSVGFCTEVEEDLIDAVTGLSGSGPAYAFTALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLHSEQHPGQLKDNVSSPGGATIHALHVLESGGFRSLLINAVEASCIRTRELQSMAD