2qwx A 1.5 BS03 ML1 A 1 F126 F178 F126 F178 G149 Y155 N161 G149 Y155 N161 1.10.5.1 0001512,0003955,0005515,0005654,0005737,0005829,0008270,0009055,0016491,0016661,0031404,0042803,0046872,0070062,0071949,1901662,1904408,1905594 Kd=1.4uM IC50=11300nM, Ki=57nM P16083 18254726 233 AGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ 2qwx A 1.5 BS04 ML1 B 1 W105 M154 W105 M154 G149 Y155 N161 G149 Y155 N161 1.10.5.1 0001512,0003955,0005515,0005654,0005737,0005829,0008270,0009055,0016491,0016661,0031404,0042803,0046872,0070062,0071949,1901662,1904408,1905594 Kd=1.4uM IC50=11300nM, Ki=57nM P16083 18254726 233 AGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ 2qwx B 1.5 BS01 ML1 A 1 W105 G149 W105 G149 G149 Y155 N161 G149 Y155 N161 1.10.5.1 0001512,0003955,0005515,0005654,0005737,0005829,0008270,0009055,0016491,0016661,0031404,0042803,0046872,0070062,0071949,1901662,1904408,1905594 Kd=1.4uM IC50=11300nM, Ki=57nM P16083 18254726 233 AGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ 2qwx B 1.5 BS04 ML1 B 1 F126 F178 F126 F178 G149 Y155 N161 G149 Y155 N161 1.10.5.1 0001512,0003955,0005515,0005654,0005737,0005829,0008270,0009055,0016491,0016661,0031404,0042803,0046872,0070062,0071949,1901662,1904408,1905594 Kd=1.4uM IC50=11300nM, Ki=57nM P16083 18254726 233 AGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ 2qx4 A 1.65 BS02 ML1 A 1 F126 F178 F126 F178 G149 Y155 N161 G149 Y155 N161 1.10.5.1 0001512,0003955,0005515,0005654,0005737,0005829,0008270,0009055,0016491,0016661,0031404,0042803,0046872,0070062,0071949,1901662,1904408,1905594 Kd=1.4uM IC50=11300nM, Ki=57nM P16083 18254726 233 AGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ 2qx4 B 1.65 BS01 ML1 A 1 W105 G149 W105 G149 G149 Y155 N161 G149 Y155 N161 1.10.5.1 0001512,0003955,0005515,0005654,0005737,0005829,0008270,0009055,0016491,0016661,0031404,0042803,0046872,0070062,0071949,1901662,1904408,1905594 Kd=1.4uM IC50=11300nM, Ki=57nM P16083 18254726 233 AGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ 2qx4 B 1.65 BS03 ML1 B 1 T71 C121 Q122 F126 F178 T71 C121 Q122 F126 F178 G149 Y155 N161 G149 Y155 N161 1.10.5.1 0001512,0003955,0005515,0005654,0005737,0005829,0008270,0009055,0016491,0016661,0031404,0042803,0046872,0070062,0071949,1901662,1904408,1905594 Kd=1.4uM IC50=11300nM, Ki=57nM P16083 18254726 233 AGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ 2qx6 A 1.75 BS02 ML1 A 1 F126 I128 F178 F126 I128 F178 G149 Y155 N161 G149 Y155 N161 1.10.5.1 0001512,0003955,0005515,0005654,0005737,0005829,0008270,0009055,0016491,0016661,0031404,0042803,0046872,0070062,0071949,1901662,1904408,1905594 Kd=1.4uM IC50=11300nM, Ki=57nM P16083 18254726 233 AGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ 2qx6 A 1.75 BS04 ML1 B 1 W105 G149 W105 G149 G149 Y155 N161 G149 Y155 N161 1.10.5.1 0001512,0003955,0005515,0005654,0005737,0005829,0008270,0009055,0016491,0016661,0031404,0042803,0046872,0070062,0071949,1901662,1904408,1905594 Kd=1.4uM IC50=11300nM, Ki=57nM P16083 18254726 233 AGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ 2qx6 B 1.75 BS01 ML1 A 1 W105 G150 W105 G150 G149 Y155 N161 G149 Y155 N161 1.10.5.1 0001512,0003955,0005515,0005654,0005737,0005829,0008270,0009055,0016491,0016661,0031404,0042803,0046872,0070062,0071949,1901662,1904408,1905594 Kd=1.4uM IC50=11300nM, Ki=57nM P16083 18254726 233 AGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ 2qx6 B 1.75 BS03 ML1 B 1 F126 F178 F126 F178 G149 Y155 N161 G149 Y155 N161 1.10.5.1 0001512,0003955,0005515,0005654,0005737,0005829,0008270,0009055,0016491,0016661,0031404,0042803,0046872,0070062,0071949,1901662,1904408,1905594 Kd=1.4uM IC50=11300nM, Ki=57nM P16083 18254726 233 AGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ 4qog A 1.4 BS02 ML1 A 1 F126 F178 F125 F177 G149 Y155 N161 G148 Y154 N160 1.10.5.1 0001512,0003955,0005515,0005654,0005737,0005829,0008270,0009055,0016491,0016661,0031404,0042803,0046872,0070062,0071949,1901662,1904408,1905594 IC50=11300nM, Ki=57nM P16083 302 GKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFG 4qog B 1.4 BS01 ML1 A 1 W105 G149 W104 G148 G149 Y155 N161 G148 Y154 N160 1.10.5.1 0001512,0003955,0005515,0005654,0005737,0005829,0008270,0009055,0016491,0016661,0031404,0042803,0046872,0070062,0071949,1901662,1904408,1905594 IC50=11300nM, Ki=57nM P16083 302 GKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFG 4qog B 1.4 BS03 ML1 B 1 G68 F126 I128 F178 G67 F125 I127 F177 G149 Y155 N161 G148 Y154 N160 1.10.5.1 0001512,0003955,0005515,0005654,0005737,0005829,0008270,0009055,0016491,0016661,0031404,0042803,0046872,0070062,0071949,1901662,1904408,1905594 IC50=11300nM, Ki=57nM P16083 302 GKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFG 4qoi A 1.55 BS03 ML1 A 1 F126 F178 F125 F177 G149 Y155 N161 G148 Y154 N160 1.10.5.1 0001512,0003955,0005515,0005654,0005737,0005829,0008270,0009055,0016491,0016661,0031404,0042803,0046872,0070062,0071949,1901662,1904408,1905594 IC50=11300nM, Ki=57nM P16083 303 GKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ 4qoi B 1.55 BS03 ML1 B 1 F126 I128 F178 F125 I127 F177 G149 Y155 N161 G148 Y154 N160 1.10.5.1 0001512,0003955,0005515,0005654,0005737,0005829,0008270,0009055,0016491,0016661,0031404,0042803,0046872,0070062,0071949,1901662,1904408,1905594 IC50=11300nM, Ki=57nM P16083 303 GKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNFEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ 5i8f A 1.3 BS01 ML1 A 1 F39 V91 G136 K139 F44 V96 G141 K144 ? 0004864,0005634,0005737,0006952,0009738,0010427,0038023 E9JSA3 27242869 210 IDPFTMAAYTIVKEEESPIAPHRLFKALVLERHQVLVKAQPHVFKSGEIIEGDGGVGTVTKITFVDGHPLTYMLHKFDEIDAANFYCKYTLFEGDVLRDNIEKVVYEVKLEAVGGGSKGKITVTYHPKPGCTVNEEEVKIGEKKAYEFYKQVEEYLAANPEVFA 5i8f A 1.3 BS02 ML1 A 2 V30 K33 Q146 Y150 V35 K38 Q151 Y155 ? 0004864,0005634,0005737,0006952,0009738,0010427,0038023 E9JSA3 27242869 211 IDPFTMAAYTIVKEEESPIAPHRLFKALVLERHQVLVKAQPHVFKSGEIIEGDGGVGTVTKITFVDGHPLTYMLHKFDEIDAANFYCKYTLFEGDVLRDNIEKVVYEVKLEAVGGGSKGKITVTYHPKPGCTVNEEEVKIGEKKAYEFYKQVEEYLAANPEVFA 5mxb A 1.51 BS01 ML1 A 1 Y9 L22 Y82 T101 V115 F143 Y9 L22 Y82 T101 V115 F143 3.1.27.- 0004518,0004540,0004864,0005509,0005634,0005737,0005829,0006952,0009738,0010427,0038023,0044373,0046872,1904408 Q9LLQ2 29630775 220 GVFTFQDEYTSTIAPAKLYKALVTDADIIIPKAVETIQSVEIVEGNGGPGTIKKLTFIEGGESKYVLHKIEAIDEANLGYNYSIVGGVGLPDTIEKISFETKLVEGANGGSIGKVTIKIETKGDAQPNEEEGKAAKARGDAFFKAIESYLSAHPD 5mxb A 1.51 BS02 ML1 A 2 I37 L55 R138 F142 I37 L55 R138 F142 3.1.27.- 0004518,0004540,0004864,0005509,0005634,0005737,0005829,0006952,0009738,0010427,0038023,0044373,0046872,1904408 Q9LLQ2 29630775 222 GVFTFQDEYTSTIAPAKLYKALVTDADIIIPKAVETIQSVEIVEGNGGPGTIKKLTFIEGGESKYVLHKIEAIDEANLGYNYSIVGGVGLPDTIEKISFETKLVEGANGGSIGKVTIKIETKGDAQPNEEEGKAAKARGDAFFKAIESYLSAHPD 5mxw A 1.57 BS01 ML1 A 1 Y9 L22 Y80 T101 V115 Y9 L22 Y80 T100 V114 3.1.27.- 0004518,0004540,0004864,0005509,0005634,0005737,0005829,0006952,0009738,0010427,0038023,0044373,0046872,1904408 Q9LLQ2 29630775 218 GVFTFQDEYTSTIAPAKLYKALVTDADIIIPKAVETIQSVEIVEGNGGPGTIKKLTFIEGGESKYVLHKIEAIDEANLGYNYSIVGGVGLDTIEKISFETKLVEGANGGSIGKVTIKIETKGDAQPNEEEGKAAKARGDAFFKAIESYLSAHPDY 6tr5 A 1.509 BS01 ML1 A 1 D270 N271 K272 D183 N184 K185 3.1.1.98 0016787 ic50=75uM Q6P988 31876313 501 DLRLHLLLNTSVTCNDGSPAGYYLKESRGSRRWLLFLEGGWYCFNRENCDSRYDTMRRLMSSRDWPRTRTGTGILSSQPEENPYWWNANMVFIPYCSSDVWSGASSKSEKNEYAFMGALIIQEVVRELLGRGLSGAKVLLLAGSSAGGTGVLLNVDRVAEQLEKLGYPAIQVRGLADSGWFLDNKQYRHTAPTEAIRRGIRYWNGVVPERCRRQFQEGEEWNCFFGYKVYPTLRSPVFVVQWLFDEAQLTVDNVHLPVQEGLRLYIQNLGRELRHTLKDVPASFAPACLSHEIIIRSHWTDVQVKGTSLPRALHCWDRSLHPLKGCPVHLVDSCPWPHCNPSCPT 6tr5 A 1.509 BS02 ML1 A 2 T236 F268 P287 F319 V346 T149 F181 P192 F224 V251 3.1.1.98 0016787 ic50=75uM Q6P988 31876313 502 DLRLHLLLNTSVTCNDGSPAGYYLKESRGSRRWLLFLEGGWYCFNRENCDSRYDTMRRLMSSRDWPRTRTGTGILSSQPEENPYWWNANMVFIPYCSSDVWSGASSKSEKNEYAFMGALIIQEVVRELLGRGLSGAKVLLLAGSSAGGTGVLLNVDRVAEQLEKLGYPAIQVRGLADSGWFLDNKQYRHTAPTEAIRRGIRYWNGVVPERCRRQFQEGEEWNCFFGYKVYPTLRSPVFVVQWLFDEAQLTVDNVHLPVQEGLRLYIQNLGRELRHTLKDVPASFAPACLSHEIIIRSHWTDVQVKGTSLPRALHCWDRSLHPLKGCPVHLVDSCPWPHCNPSCPT