1dmh A 1.7 BS02 MCT A 1 L73 P76 P108 L109 Y164 Y200 R221 H224 H226 L71 P74 P106 L107 Y162 Y198 R219 H222 H224 Y164 Y200 R221 H224 H226 Y162 Y198 R219 H222 H224 1.13.11.1 0003824,0005506,0005575,0008199,0009056,0009712,0016702,0018576,0019614,0042952,0046872,0051213 P07773 10801478 401 VKIFNTQDVQDFLRVASGLEQEGGNPRVKQIIHRVLSDLYKAIEDLNITSDEYWAGVAYLNQLGANQEAGLLSPGLGFDHYLDMRMDAEDAALGIENATPRTIEGPLYVAGAPESVGYARMDDGSDPNGHTLILHGTIFDADGKPLPNAKVEIWHANTKGFYSHFDPTGEQQAFNMRRSIITDENGQYRVRTILPAGYGCPPEGPTQQLLNQLGRHGNRPAHIHYFVSADGHRKLTTQINVAGDPYTYDDFAYATREGLVVDAVEHTDPEAIKANDVEGPFAEMVFDLKLTRLVDGVDNQVVDRPRLAV 1dmh B 1.7 BS02 MCT B 1 P76 P108 Y164 Y200 R221 H224 H226 P74 P106 Y162 Y198 R219 H222 H224 Y164 Y200 R221 H224 H226 Y162 Y198 R219 H222 H224 1.13.11.1 0003824,0005506,0005575,0008199,0009056,0009712,0016702,0018576,0019614,0042952,0046872,0051213 P07773 10801478 401 VKIFNTQDVQDFLRVASGLEQEGGNPRVKQIIHRVLSDLYKAIEDLNITSDEYWAGVAYLNQLGANQEAGLLSPGLGFDHYLDMRMDAEDAALGIENATPRTIEGPLYVAGAPESVGYARMDDGSDPNGHTLILHGTIFDADGKPLPNAKVEIWHANTKGFYSHFDPTGEQQAFNMRRSIITDENGQYRVRTILPAGYGCPPEGPTQQLLNQLGRHGNRPAHIHYFVSADGHRKLTTQINVAGDPYTYDDFAYATREGLVVDAVEHTDPEAIKANDVEGPFAEMVFDLKLTRLVDGVDNQVVDRPRLAV 1l4g A 2.1 BS01 MCT A 1 Q88 L315 E317 Q85 L312 E314 E174 E317 E171 E314 2.4.2.21 0000166,0008939,0009236,0016757 Q05603 12101181 990 LHALLRDIPAPDAEAMARTQQHIDGLLKPPGSLGRLETLAVQLAGMPGLNGTPQVGEKAVLVMCADHGVWDEGVAVSPKIVTAIQAANMTRGTTGVCVLAAQAGAKVHVIDVGIDAEPIPGVVNMRVARGCGNIAVGPAMSRLQAEALLLEVSRYTCDLAQRGVTLFGVGELGMANTTPAAAMVSVFTGSDAKEVVGIGANLPPSRIDNKVDVVRRAIAINQPNPRDGIDVLSKVGGFDLVGMTGVMLGAARCGLPVLLDGFLSYSAALAACQIAPAVRPYLIPSHFSAEKGARIALAHLSMEPYLHMAMRLGEGSGAALAMPIVEAACAMFHNMGELAASNIVLP 2ehz A 1.35 BS02 MCT A 1 H152 Y178 F192 H200 H215 H247 N249 Y256 H149 Y175 F189 H197 H212 H244 N246 Y253 1.13.11.56 0003824,0008198,0009056,0016702,0018554,0046872,0051213,1901170 P0A108 1600 QAAVIELGYMGISVKDPDAWKSFATDMLGLQVLDEGEKDRFYLRMDYWHHRIVVHHNGQDDLEYLGWRVAGKPEFEALGQKLIDAGYKIRICDKVEAQERMVLGLMKTEDPGGNPTEIFWGPRIDMSNPFHPGRPLHGKFVTGDQGLGHCIVRQTDVAEAHKFYSLLGFRGDVEYRIPLPNGMTAELSFMHCNARDHSIAFGAMPAAKRLNHLMLEYTHMEDLGYTHQQFVKNEIDIALQLGIHANDKALTFYGATPSGWLIEPGWRGATAIDEAEYYVGDIFGHGVEATGYGLDVKLS 2ehz A 1.35 BS03 MCT A 2 I154 V155 R156 F204 G205 M207 N214 I151 V152 R153 F201 G202 M204 N211 1.13.11.56 0003824,0008198,0009056,0016702,0018554,0046872,0051213,1901170 P0A108 1601 QAAVIELGYMGISVKDPDAWKSFATDMLGLQVLDEGEKDRFYLRMDYWHHRIVVHHNGQDDLEYLGWRVAGKPEFEALGQKLIDAGYKIRICDKVEAQERMVLGLMKTEDPGGNPTEIFWGPRIDMSNPFHPGRPLHGKFVTGDQGLGHCIVRQTDVAEAHKFYSLLGFRGDVEYRIPLPNGMTAELSFMHCNARDHSIAFGAMPAAKRLNHLMLEYTHMEDLGYTHQQFVKNEIDIALQLGIHANDKALTFYGATPSGWLIEPGWRGATAIDEAEYYVGDIFGHGVEATGYGLDVKLS 2ehz A 1.35 BS04 MCT A 3 L244 F286 L241 F283 1.13.11.56 0003824,0008198,0009056,0016702,0018554,0046872,0051213,1901170 P0A108 1602 QAAVIELGYMGISVKDPDAWKSFATDMLGLQVLDEGEKDRFYLRMDYWHHRIVVHHNGQDDLEYLGWRVAGKPEFEALGQKLIDAGYKIRICDKVEAQERMVLGLMKTEDPGGNPTEIFWGPRIDMSNPFHPGRPLHGKFVTGDQGLGHCIVRQTDVAEAHKFYSLLGFRGDVEYRIPLPNGMTAELSFMHCNARDHSIAFGAMPAAKRLNHLMLEYTHMEDLGYTHQQFVKNEIDIALQLGIHANDKALTFYGATPSGWLIEPGWRGATAIDEAEYYVGDIFGHGVEATGYGLDVKLS 2ehz A 1.35 BS05 MCT A 4 H58 E102 R103 H55 E99 R100 1.13.11.56 0003824,0008198,0009056,0016702,0018554,0046872,0051213,1901170 P0A108 1603 QAAVIELGYMGISVKDPDAWKSFATDMLGLQVLDEGEKDRFYLRMDYWHHRIVVHHNGQDDLEYLGWRVAGKPEFEALGQKLIDAGYKIRICDKVEAQERMVLGLMKTEDPGGNPTEIFWGPRIDMSNPFHPGRPLHGKFVTGDQGLGHCIVRQTDVAEAHKFYSLLGFRGDVEYRIPLPNGMTAELSFMHCNARDHSIAFGAMPAAKRLNHLMLEYTHMEDLGYTHQQFVKNEIDIALQLGIHANDKALTFYGATPSGWLIEPGWRGATAIDEAEYYVGDIFGHGVEATGYGLDVKLS 2ehz A 1.35 BS06 MCT A 5 H194 N196 A197 A274 D276 H191 N193 A194 A271 D273 1.13.11.56 0003824,0008198,0009056,0016702,0018554,0046872,0051213,1901170 P0A108 1604 QAAVIELGYMGISVKDPDAWKSFATDMLGLQVLDEGEKDRFYLRMDYWHHRIVVHHNGQDDLEYLGWRVAGKPEFEALGQKLIDAGYKIRICDKVEAQERMVLGLMKTEDPGGNPTEIFWGPRIDMSNPFHPGRPLHGKFVTGDQGLGHCIVRQTDVAEAHKFYSLLGFRGDVEYRIPLPNGMTAELSFMHCNARDHSIAFGAMPAAKRLNHLMLEYTHMEDLGYTHQQFVKNEIDIALQLGIHANDKALTFYGATPSGWLIEPGWRGATAIDEAEYYVGDIFGHGVEATGYGLDVKLS 2ehz A 1.35 BS07 MCT A 6 Q62 L65 E66 R212 Q59 L62 E63 R209 1.13.11.56 0003824,0008198,0009056,0016702,0018554,0046872,0051213,1901170 P0A108 1605 QAAVIELGYMGISVKDPDAWKSFATDMLGLQVLDEGEKDRFYLRMDYWHHRIVVHHNGQDDLEYLGWRVAGKPEFEALGQKLIDAGYKIRICDKVEAQERMVLGLMKTEDPGGNPTEIFWGPRIDMSNPFHPGRPLHGKFVTGDQGLGHCIVRQTDVAEAHKFYSLLGFRGDVEYRIPLPNGMTAELSFMHCNARDHSIAFGAMPAAKRLNHLMLEYTHMEDLGYTHQQFVKNEIDIALQLGIHANDKALTFYGATPSGWLIEPGWRGATAIDEAEYYVGDIFGHGVEATGYGLDVKLS 3fw5 A 2.3 BS01 MCT A 1 K125 F133 K134 K122 F130 K131 ? 0005506,0005515,0005576,0005615,0006826,0006915,0015891,0031410,0035580,0036094,0042742,0042802,0045087,0060205,0070062,0120162,0140315,1903981 P80188 20581821 180 TSDLIPAPPLSKVPLQQNFQDNQFQGKWYVVGLAGNAILREDKDPQKMYATIYELKEDKSYNVTSVLFRKKKCDYWIRTFVPGSQPGEFTLGNIKSYPGLTSYLVRVVSTNYNQHAMVFFKKVSQNREYFKITLYGRTKELTSELKENFIRFSKSLGLPENHIVFPVPIDQCIDG 3fw5 B 2.3 BS01 MCT B 1 Y106 K125 Y132 F133 K134 Y95 K114 Y121 F122 K123 ? 0005506,0005515,0005576,0005615,0006826,0006915,0015891,0031410,0035580,0036094,0042742,0042802,0045087,0060205,0070062,0120162,0140315,1903981 P80188 20581821 180 SDLIPAPPLSKVPLQQNFQDNQFQGKWYVVGLAGNAILQKMYATIYELKDKSYNVTSVLFRKKKCDYWIRTFVPGSQPGEFTLGNIKSYPGLTSYLVRVVSTNYNQHAMVFFKKVSQNREYFKITLYGRTKELKENFIRFSKSGLPENHIVFPVPIDQCID 3fw5 C 2.3 BS01 MCT C 1 K125 K134 K122 K131 ? 0005506,0005515,0005576,0005615,0006826,0006915,0015891,0031410,0035580,0036094,0042742,0042802,0045087,0060205,0070062,0120162,0140315,1903981 P80188 20581821 180 TSDLIPAPPLSKVPLQQNFQDNQFQGKWYVVGLAGNAILREDKDPQKMYATIYELKEDKSYNVTSVLFRKKKCDYWIRTFVPGSQPGEFTLGNIKSYPGLTSYLVRVVSTNYNQHAMVFFKKVSQNREYFKITLYGRTKELTSELKENFIRFSKSLGLPENHIVFPVPIDQCID 3hjs A 1.8 BS02 MCT A 1 D80 V81 P105 Y106 Y162 Y196 R217 H220 H222 D56 V57 P81 Y82 Y138 Y172 R193 H196 H198 Y162 Y196 R217 H220 H222 Y138 Y172 R193 H196 H198 1.13.11.1 0003824,0005506,0008199,0009056,0009712,0016702,0018576,0046872,0051213 Ki=4uM P95607 20040374 283 ATADTSPERLAAIAKDALGALNDVILKHGVTYPEYRVFKQWLIDVGEGGEWPLFLDVFIEHSVEEVLARSRKGTMGSIEGPYYIENSPELPSKCTLPMREEDEKITPLVFSGQVTDLDGNGLAGAKVELWHADNDGYYSQFAPHLPEWNLRGTIIADEEGRYEITTIQPAPYQIPTDGPTGQFIEAQNGHPWRPAHLHLIVSAPGKESVTTQLYFKGGEWIDSDVASATKPELILDPKTGDDGKNYVTYNFVLDPA 3hpy A 1.94 BS02 MCT A 1 W193 H201 H216 H248 V250 T251 Y257 W192 H200 H215 H247 V249 T250 Y256 H154 H201 H216 H248 Y257 E267 H153 H200 H215 H247 Y256 E266 1.13.11.2 0003824,0008198,0009056,0018577,0046872,0051213 Q7WYF5 19828456 311 AMTGVLRPGHAQVRVLNLEEGIHFYRNVLGLVETGRDDQGRVYFKCWDERDHSCYIIREADTAGIDFFGFKVLDKATLEKLDADLQAYGLTTTRIPAGEMLETGERVRFELPSGHLIELYAEKTCVGNGISEVNPAPWNAQREHGIAPIQLDHCLLYGPNIAEVQKIFTEVLGFYLVERVLSPDGDSDMGIWLSCSHKVHDIAFVEYPEKGKLHHCSFLLESWEQVLRAGDIMSMNEVNVDIGPTRHGVTRGCTIYAWDPSGNRFETFMGGYHPYPDYEPLSWTYDNF 3hpy B 1.94 BS02 MCT B 1 W193 H201 H216 H248 V250 T251 Y257 W192 H200 H215 H247 V249 T250 Y256 H154 H201 H216 H248 Y257 E267 H153 H200 H215 H247 Y256 E266 1.13.11.2 0003824,0008198,0009056,0018577,0046872,0051213 Q7WYF5 19828456 311 AMTGVLRPGHAQVRVLNLEEGIHFYRNVLGLVETGRDDQGRVYFKCWDERDHSCYIIREADTAGIDFFGFKVLDKATLEKLDADLQAYGLTTTRIPAGEMLETGERVRFELPSGHLIELYAEKTCVGNGISEVNPAPWNAQREHGIAPIQLDHCLLYGPNIAEVQKIFTEVLGFYLVERVLSPDGDSDMGIWLSCSHKVHDIAFVEYPEKGKLHHCSFLLESWEQVLRAGDIMSMNEVNVDIGPTRHGVTRGCTIYAWDPSGNRFETFMGGYHPYPDYEPLSWTYDNF 3hpy C 1.94 BS02 MCT C 1 H154 W193 H201 H216 H248 V250 Y257 E267 H153 W192 H200 H215 H247 V249 Y256 E266 H154 H201 H216 H248 Y257 E267 H153 H200 H215 H247 Y256 E266 1.13.11.2 0003824,0008198,0009056,0018577,0046872,0051213 Q7WYF5 19828456 311 AMTGVLRPGHAQVRVLNLEEGIHFYRNVLGLVETGRDDQGRVYFKCWDERDHSCYIIREADTAGIDFFGFKVLDKATLEKLDADLQAYGLTTTRIPAGEMLETGERVRFELPSGHLIELYAEKTCVGNGISEVNPAPWNAQREHGIAPIQLDHCLLYGPNIAEVQKIFTEVLGFYLVERVLSPDGDSDMGIWLSCSHKVHDIAFVEYPEKGKLHHCSFLLESWEQVLRAGDIMSMNEVNVDIGPTRHGVTRGCTIYAWDPSGNRFETFMGGYHPYPDYEPLSWTYDNFAQGLDYPQ 4k7n A 2.3 BS01 MCT A 1 P40 T44 P45 G46 C47 R127 P40 T44 P45 G46 C47 R127 1.11.1.24 0008379,0016491,0034599 Kd=330uM -logKd/Ki=3.48, Kd=330uM P30044 25025339 201 APIKVGDAIPAVEVFEGEPGNKVNLAELFKGKKGVLFGVPGAFTPGCSKTHLPGFVEQAEALKAKGVQVVACLSVNDAFVTGEWGRAHKAEGKVRLLADPTGAFGKETDLLLDDSLVSIFGNRRLKRFSMVVQDGIVKALNVEPDGTGLTCSLAPNIISQL 4k7n B 2.3 BS01 MCT B 1 T44 P45 G46 C47 R127 T44 P45 G46 C47 R127 1.11.1.24 0008379,0016491,0034599 Kd=330uM -logKd/Ki=3.48, Kd=330uM P30044 25025339 201 APIKVGDAIPAVEVFEGEPGNKVNLAELFKGKKGVLFGVPGAFTPGCSKTHLPGFVEQAEALKAKGVQVVACLSVNDAFVTGEWGRAHKAEGKVRLLADPTGAFGKETDLLLDDSLVSIFGNRRLKRFSMVVQDGIVKALNVEPDGTGLTCSLAPNIISQL 4k7n C 2.3 BS01 MCT C 1 T44 P45 G46 C47 R127 T44 P45 G46 C47 R127 1.11.1.24 0008379,0016491,0034599 Kd=330uM P30044 25025339 201 APIKVGDAIPAVEVFEGEPGNKVNLAELFKGKKGVLFGVPGAFTPGCSKTHLPGFVEQAEALKAKGVQVVACLSVNDAFVTGEWGRAHKAEGKVRLLADPTGAFGKETDLLLDDSLVSIFGNRRLKRFSMVVQDGIVKALNVEPDGTGLTCSLAPNIISQL 5znh A 2.4 BS02 MCT A 1 H150 F198 H206 H220 H252 I254 T255 Y261 E271 F273 I298 H150 F198 H206 H220 H252 I254 T255 Y261 E271 F273 I298 H150 H206 H220 H252 Y261 E271 H150 H206 H220 H252 Y261 E271 1.13.11.2 0003824,0008198,0009056,0018577,0046872,0051213 A0A4V8GZK8 402 MGVLRIGHASLKVMDMDAAVRHYENVLGMKTTMKDKAGNVYLKCWDEWDKYSVILTPSDQAGMNHLAYKVEKEADLEALQQKIEAWGVKTTMLDEGTLPSTGRMLQFKLPSGHEMRLYASKEFVGTDVGNINPDPWPDGLKGAGAHWLDHCLLVCEMNPEAGINTVADNTRFVTECLDFFLTEQVLVGPGGSIQATTFLARTTTPHDIAFVGGPTSGLHHIAFFLDSWHDVLKAADVMAKNKVRIDVAPTRHGITRGETIYFFDPSGNRNETFAGLGYLAQRDRPVTTWTEDQLGSAIFYHTGYLEPSFTDVYT