1jt1 A 1.78 BS03 MCO A 1 S221 G223 M266 Y293 K297 D300 S173 G175 M217 Y244 K248 D251 H116 H118 D120 H121 H196 Y228 H263 H70 H72 D74 H75 H148 Y180 H214 3.5.2.6 Ki=400uM -logKd/Ki=3.40, Ki=400uM Q9K578 12507470 700 YPMPNPFPPFRIAGNLYYVGTDDLASYLIVTPRGNILINSDLEANVPMIKASIKKLGFKFSDTKILLISHAHFDHAAGSELIKQQTKAKYMVMDEDVSVILSGGKSDFHYANDSSTYFTQSTVDKVLHDGERVELGGTVLTAHLTPGHTRGCTTWTMKLKDHGKQYQAVIIGSIGVNPGYKLVDNITYPKIAEDYKHSIKVLESMRCDIFLGSHAGMFDLKNKYVLLSKGQNNPFVDPTGCKNYIEQKANDFYTELKKQETG 1m2x A 1.5 BS04 MCO A 1 H118 D119 D120 K167 H196 Y233 H74 D75 D76 K106 H135 Y166 H116 H118 D120 H196 C221 K224 Y233 H263 H72 H74 D76 H135 C154 K157 Y166 H196 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 Ki~85uM -logKd/Ki=4.15, Ki=70uM O08498 12684522 811 DVKIEKLKDNLYVYTTYNTFNGTKYAANAVYLVTDKGVVVIDCPWGEDKFKSFTDEIYKKHGKKVIMNIATHSHDDRAGGLEYFGKIGAKTYSTKMTDSILAKENKPRAQYTFDNNKSFKVGKSEFQVYYPGKGHTADNVVVWFPKEKVLVGGCIIKSADSKDLGYIGEAYVNDWTQSVHNIQQKFSGAQYVVAGHDDWKDQRSIQHTLDLINEYQQKQ 1m2x B 1.5 BS04 MCO B 1 H118 D119 D120 K167 H196 Y233 H74 D75 D76 K106 H135 Y166 H116 H118 D120 H196 C221 K224 Y233 H263 H72 H74 D76 H135 C154 K157 Y166 H196 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 Ki~85uM O08498 12684522 812 DVKIEKLKDNLYVYTTYNTFNGTKYAANAVYLVTDKGVVVIDCPWGEDKFKSFTDEIYKKHGKKVIMNIATHSHDDRAGGLEYFGKIGAKTYSTKMTDSILAKENKPRAQYTFDNNKSFKVGKSEFQVYYPGKGHTADNVVVWFPKEKVLVGGCIIKSADSKDLGYIGEAYVNDWTQSVHNIQQKFSGAQYVVAGHDDWKDQRSIQHTLDLINEYQQKQ 1m2x C 1.5 BS04 MCO C 1 H118 D119 D120 K167 H196 Y233 H74 D75 D76 K106 H135 Y166 H116 H118 D120 H196 C221 K224 Y233 H263 H72 H74 D76 H135 C154 K157 Y166 H196 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 Ki~85uM O08498 12684522 813 DVKIEKLKDNLYVYTTYNTFNGTKYAANAVYLVTDKGVVVIDCPWGEDKFKSFTDEIYKKHGKKVIMNIATHSHDDRAGGLEYFGKIGAKTYSTKMTDSILAKENKPRAQYTFDNNKSFKVGKSEFQVYYPGKGHTADNVVVWFPKEKVLVGGCIIKSADSKDLGYIGEAYVNDWTQSVHNIQQKFSGAQYVVAGHDDWKDQRSIQHTLDLINEYQQ 1m2x D 1.5 BS04 MCO D 1 H118 D119 D120 K167 H196 Y233 H74 D75 D76 K106 H135 Y166 H116 H118 D120 H196 C221 K224 Y233 H263 H72 H74 D76 H135 C154 K157 Y166 H196 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 Ki~85uM O08498 12684522 814 DVKIEKLKDNLYVYTTYNTFNGTKYAANAVYLVTDKGVVVIDCPWGEDKFKSFTDEIYKKHGKKVIMNIATHSHDDRAGGLEYFGKIGAKTYSTKMTDSILAKENKPRAQYTFDNNKSFKVGKSEFQVYYPGKGHTADNVVVWFPKEKVLVGGCIIKSADSKDLGYIGEAYVNDWTQSVHNIQQKFSGAQYVVAGHDDWKDQRSIQHTLDLINEYQQKQ 1uzf A 2.0 BS02 MCO A 1 Q281 H353 H383 E384 H387 K511 H513 Y520 Y523 Q242 H314 H344 E345 H348 K468 H470 Y477 Y480 H353 A354 H383 E384 H387 E411 H513 Y523 H314 A315 H344 E345 H348 E372 H470 Y480 3.4.15.1 0006508,0008237,0008241,0016020 P12821 15236580 702 DEAEASKFVEEYDRTSQVVWNEYAEANWNYNTNITTETSKILLQKNMQIANHTLKYGTQARKFDVNQLQNTTIKRIIKKVQDLERAALPAQELEEYNKILLDMETTYSVATVCHPNGSCLQLEPDLTNVMATSRKYEDLLWAWEGWRDKAGRAILQFYPKYVELINQAARLNGYVDAGDSWRSMYETPSLEQDLERLFQELQPLYLNLHAYVRRALHRHYGAQHINLEGPIPAHLLGNMWAQTWSNIYDLVVPFPSAPSMDTTEAMLKQGWTPRRMFKEADDFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHASAWDFYNGKDFRIKQCTTVNLEDLVVAHHEMGHIQYFMQYKDLPVALREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSDEHDINFLMKMALDKIAFIPFSYLVDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRTQGDFDPGAKFHIPSSVPYIRYFVSFIIQFQFHEALCQAAGHTGPLHKCDIYQSKEAGQRLATAMKLGFSRPWPEAMQLITGQPNMSASAMLSYFKPLLDWLRTENELHGEKLGWP 2fu8 A 1.8 BS03 MCO A 1 Y33 W39 D120 H196 S225 P227 H263 Y10 W16 D87 H159 S186 P188 H224 H116 H118 D120 H121 H196 Y229 H263 H83 H85 D87 H88 H159 Y190 H224 3.5.2.6 0008270,0008800,0016787,0017001,0030655,0042597,0046677,0046872 Ki=20uM -logKd/Ki=4.70, Ki=20uM P52700 17999929 1410 EVPLPQLRAYTVDASWLQPMAPLQIADHTWQIGTEDLTALLVQTPDGAVLLDGGMPQMASHLLDNMKARGVTPRDLRLILLSHAHADHAGPVAELKRRTGAKVAANAESAVLLARGGSDDLHFGDGITYPPANADRIVMDGEVITVGGIVFTAHFMAGHTPGSTAWTWTDTRNGKPVRIAYADSLSAPGYQLQGNPRYPHLIEDYRRSFATVRALPCDVLLTPHPGASNWDYAAGARAGAKALTCKAYADAAEQKFDGQLAKETAG 2fu8 B 1.8 BS03 MCO B 1 Y33 W39 D120 H196 S225 P227 H263 Y10 W16 D87 H159 S186 P188 H224 H116 H118 D120 H121 H196 Y229 H263 H83 H85 D87 H88 H159 Y190 H224 3.5.2.6 0008270,0008800,0016787,0017001,0030655,0042597,0046677,0046872 Ki=20uM P52700 17999929 2410 EVPLPQLRAYTVDASWLQPMAPLQIADHTWQIGTEDLTALLVQTPDGAVLLDGGMPQMASHLLDNMKARGVTPRDLRLILLSHAHADHAGPVAELKRRTGAKVAANAESAVLLARGGSDDLHFGDGITYPPANADRIVMDGEVITVGGIVFTAHFMAGHTPGSTAWTWTDTRNGKPVRIAYADSLSAPGYQLQGNPRYPHLIEDYRRSFATVRALPCDVLLTPHPGASNWDYAAGARAGAKALTCKAYADAAEQKFDGQLAKETAG 2qds A 1.66 BS02 MCO A 1 D120 H196 N233 D72 H147 N174 N116 H118 D120 H196 C221 K224 N233 H263 N68 H70 D72 H147 C166 K169 N174 H204 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 Ki=72uM P26918 18563261 501 AGMSLTQVSGPVYVVEDNYYVQENSMVYFGAKGVTVVGATWTPDTARELHKLIKRVSRKPVLEVINTNYHTDRAGGNAYWKSIGAKVVSTRQTRDLMKSDWAEIVAFTRKGLPEYPDLPLVLPNVVHDGDFTLQEGKVRAFYAGPAHTPDGIFVYFPDEQVLYGNCILKEKLGNLSFADVKAYPQTLERLKAMKLPIKTVIGGHDSPLHGPELIDHYEALIKAA 4c1c A 1.18 BS01 MCO A 1 H118 D120 H179 C198 K201 G209 N210 H240 H79 D81 H140 C159 K162 G170 N171 H201 H116 H118 D120 H179 C198 K201 N210 H240 H77 H79 D81 H140 C159 K162 N171 H201 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 -logKd/Ki=4.97, IC50=10.7uM P04190 26482303 1261 KTVIKNETGTISISQLNKNVWVHTELGSAVPSNGLVLNTSKGLVLVDSSWDDKLTKELIEMVEKKFQKRVTDVIITHAHADRIGGIKTLKERGIKAHSTALTAELAKKNGYEEPLGDLQTVTNLKFGNMKVETFYPGKGHTEDNIVVWLPQYNILVGGCLVKSTSAKDLGNVADAYVNEWSTSIENVLKRYRNINAVVPGHGEVGDKGLLLHTLDLLK 4c1e A 1.399 BS01 MCO A 1 F62 Y67 W87 H116 D118 H179 R205 G209 N210 H240 F31 Y36 W56 H85 D87 H148 R174 G178 N179 H209 H114 H116 D118 H179 C198 Y201 N210 H240 H83 H85 D87 H148 C167 Y170 N179 H209 3.5.2.6 0016787,0017001,0046872 -logKd/Ki=7.14, IC50=0.072uM Q9K2N0 26482303 350 EYPTVSEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNR 4c1e B 1.399 BS01 MCO B 1 F62 Y67 W87 H116 D118 H179 R205 G209 N210 H240 F31 Y36 W56 H85 D87 H148 R174 G178 N179 H209 H114 H116 D118 H179 C198 Y201 N210 H240 H83 H85 D87 H148 C167 Y170 N179 H209 3.5.2.6 0016787,0017001,0046872 Q9K2N0 26482303 350 EYPTVSEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNR 4c1g A 1.714 BS03 MCO A 1 W46 V49 D99 H157 K179 G184 W26 V29 D79 H137 K159 G164 H95 H97 D99 H157 C176 K179 N185 H215 H75 H77 D79 H137 C156 K159 N165 H195 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 -logKd/Ki=5.14, IC50=7.2uM P52699 26482303 305 SLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESK 5zj2 A 1.1 BS03 MCO A 1 M67 V73 W93 H122 D124 H189 G219 N220 H250 M26 V32 W52 H81 D83 H148 G178 N179 H209 H120 H122 D124 H189 C208 K211 N220 H250 H79 H81 D83 H148 C167 K170 N179 H209 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 C7C422 303 GDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR