1mt5 A 2.8 BS01 MAY A 1 M191 L192 S193 S217 D237 I238 G239 S241 A377 L380 F381 F432 T488 I491 M155 L156 S157 S181 D201 I202 G203 S205 A341 L344 F345 F396 T452 I455 K142 S217 S218 T236 I238 G239 G240 S241 F244 K106 S181 S182 T200 I202 G203 G204 S205 F208 3.1.1.-,3.5.1.99 0000139,0004040,0005515,0005543,0005783,0005789,0005794,0006631,0008289,0009062,0016020,0016042,0016787,0016788,0017064,0031090,0042802,0045907,0047372,0052651,0098793,0098794,0098978,0150036 IC50=2.5nM P97612 12459591 600 ARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMT 1mt5 B 2.8 BS01 MAY B 1 L192 S193 S217 D237 I238 G239 S241 L372 A377 L380 F381 F432 I491 W531 L156 S157 S181 D201 I202 G203 S205 L336 A341 L344 F345 F396 I455 W495 K142 S217 S218 T236 I238 G239 G240 S241 F244 K106 S181 S182 T200 I202 G203 G204 S205 F208 3.1.1.-,3.5.1.99 0000139,0004040,0005515,0005543,0005783,0005789,0005794,0006631,0008289,0009062,0016020,0016042,0016787,0016788,0017064,0031090,0042802,0045907,0047372,0052651,0098793,0098794,0098978,0150036 IC50=2.5nM P97612 12459591 600 ARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMT 1mt5 C 2.8 BS01 MAY C 1 M191 L192 S193 F194 S217 D237 I238 G239 S241 L372 A377 F432 I491 M155 L156 S157 F158 S181 D201 I202 G203 S205 L336 A341 F396 I455 K142 S217 S218 T236 I238 G239 G240 S241 F244 K106 S181 S182 T200 I202 G203 G204 S205 F208 3.1.1.-,3.5.1.99 0000139,0004040,0005515,0005543,0005783,0005789,0005794,0006631,0008289,0009062,0016020,0016042,0016787,0016788,0017064,0031090,0042802,0045907,0047372,0052651,0098793,0098794,0098978,0150036 IC50=2.5nM P97612 12459591 600 ARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMT 1mt5 D 2.8 BS01 MAY D 1 M191 L192 S193 S217 D237 I238 G239 S241 L372 A377 L380 F381 L404 F432 T488 I491 M155 L156 S157 S181 D201 I202 G203 S205 L336 A341 L344 F345 L368 F396 T452 I455 K142 S217 S218 T236 I238 G239 G240 S241 F244 K106 S181 S182 T200 I202 G203 G204 S205 F208 3.1.1.-,3.5.1.99 0000139,0004040,0005515,0005543,0005783,0005789,0005794,0006631,0008289,0009062,0016020,0016042,0016787,0016788,0017064,0031090,0042802,0045907,0047372,0052651,0098793,0098794,0098978,0150036 IC50=2.5nM P97612 12459591 600 ARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMT 1mt5 E 2.8 BS01 MAY E 1 L192 S193 S217 D237 I238 G239 S241 L372 A377 L380 F381 F432 T488 I491 L156 S157 S181 D201 I202 G203 S205 L336 A341 L344 F345 F396 T452 I455 K142 S217 S218 T236 I238 G239 G240 S241 F244 K106 S181 S182 T200 I202 G203 G204 S205 F208 3.1.1.-,3.5.1.99 0000139,0004040,0005515,0005543,0005783,0005789,0005794,0006631,0008289,0009062,0016020,0016042,0016787,0016788,0017064,0031090,0042802,0045907,0047372,0052651,0098793,0098794,0098978,0150036 IC50=2.5nM P97612 12459591 600 ARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMT 1mt5 F 2.8 BS01 MAY F 1 M191 L192 S193 S217 D237 I238 G239 S241 A377 L380 F381 F432 T488 M155 L156 S157 S181 D201 I202 G203 S205 A341 L344 F345 F396 T452 K142 S217 S218 T236 I238 G239 G240 S241 F244 K106 S181 S182 T200 I202 G203 G204 S205 F208 3.1.1.-,3.5.1.99 0000139,0004040,0005515,0005543,0005783,0005789,0005794,0006631,0008289,0009062,0016020,0016042,0016787,0016788,0017064,0031090,0042802,0045907,0047372,0052651,0098793,0098794,0098978,0150036 IC50=2.5nM P97612 12459591 600 ARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMT 1mt5 G 2.8 BS01 MAY G 1 L192 S193 F194 S217 D237 I238 G239 S241 L372 A377 L380 F381 F432 I491 L156 S157 F158 S181 D201 I202 G203 S205 L336 A341 L344 F345 F396 I455 K142 S217 S218 T236 I238 G239 G240 S241 F244 K106 S181 S182 T200 I202 G203 G204 S205 F208 3.1.1.-,3.5.1.99 0000139,0004040,0005515,0005543,0005783,0005789,0005794,0006631,0008289,0009062,0016020,0016042,0016787,0016788,0017064,0031090,0042802,0045907,0047372,0052651,0098793,0098794,0098978,0150036 IC50=2.5nM P97612 12459591 600 ARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMT 1mt5 H 2.8 BS01 MAY H 1 L192 S193 S217 D237 I238 G239 S241 L372 A377 L380 F381 F432 I491 L156 S157 S181 D201 I202 G203 S205 L336 A341 L344 F345 F396 I455 K142 S217 S218 T236 I238 G239 G240 S241 F244 K106 S181 S182 T200 I202 G203 G204 S205 F208 3.1.1.-,3.5.1.99 0000139,0004040,0005515,0005543,0005783,0005789,0005794,0006631,0008289,0009062,0016020,0016042,0016787,0016788,0017064,0031090,0042802,0045907,0047372,0052651,0098793,0098794,0098978,0150036 IC50=2.5nM P97612 12459591 600 ARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMT 1mt5 I 2.8 BS01 MAY I 1 S193 S217 D237 I238 G239 S241 L372 A377 L380 F381 F432 I491 S157 S181 D201 I202 G203 S205 L336 A341 L344 F345 F396 I455 K142 S217 S218 T236 I238 G239 G240 S241 F244 K106 S181 S182 T200 I202 G203 G204 S205 F208 3.1.1.-,3.5.1.99 0000139,0004040,0005515,0005543,0005783,0005789,0005794,0006631,0008289,0009062,0016020,0016042,0016787,0016788,0017064,0031090,0042802,0045907,0047372,0052651,0098793,0098794,0098978,0150036 IC50=2.5nM P97612 12459591 600 ARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMT 1mt5 J 2.8 BS01 MAY J 1 L192 S193 F194 S217 D237 I238 G239 S241 L372 A377 L380 F381 L404 F432 T488 I491 W531 L156 S157 F158 S181 D201 I202 G203 S205 L336 A341 L344 F345 L368 F396 T452 I455 W495 K142 S217 S218 T236 I238 G239 G240 S241 F244 K106 S181 S182 T200 I202 G203 G204 S205 F208 3.1.1.-,3.5.1.99 0000139,0004040,0005515,0005543,0005783,0005789,0005794,0006631,0008289,0009062,0016020,0016042,0016787,0016788,0017064,0031090,0042802,0045907,0047372,0052651,0098793,0098794,0098978,0150036 IC50=2.5nM P97612 12459591 600 ARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMT 1mt5 K 2.8 BS01 MAY K 1 L192 S193 S217 D237 I238 G239 S241 L372 A377 L380 F381 F432 T488 I491 L156 S157 S181 D201 I202 G203 S205 L336 A341 L344 F345 F396 T452 I455 K142 S217 S218 T236 I238 G239 G240 S241 F244 K106 S181 S182 T200 I202 G203 G204 S205 F208 3.1.1.-,3.5.1.99 0000139,0004040,0005515,0005543,0005783,0005789,0005794,0006631,0008289,0009062,0016020,0016042,0016787,0016788,0017064,0031090,0042802,0045907,0047372,0052651,0098793,0098794,0098978,0150036 IC50=2.5nM P97612 12459591 600 ARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMT 1mt5 L 2.8 BS01 MAY L 1 M191 L192 S193 S217 D237 I238 G239 S241 L372 A377 F432 I491 M155 L156 S157 S181 D201 I202 G203 S205 L336 A341 F396 I455 K142 S217 S218 T236 I238 G239 G240 S241 F244 K106 S181 S182 T200 I202 G203 G204 S205 F208 3.1.1.-,3.5.1.99 0000139,0004040,0005515,0005543,0005783,0005789,0005794,0006631,0008289,0009062,0016020,0016042,0016787,0016788,0017064,0031090,0042802,0045907,0047372,0052651,0098793,0098794,0098978,0150036 IC50=2.5nM P97612 12459591 600 ARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMT 1mt5 M 2.8 BS01 MAY M 1 L192 S193 D237 I238 G239 G240 S241 A377 F381 L404 F432 T488 I491 L156 S157 D201 I202 G203 G204 S205 A341 F345 L368 F396 T452 I455 K142 S217 S218 T236 I238 G239 G240 S241 F244 K106 S181 S182 T200 I202 G203 G204 S205 F208 3.1.1.-,3.5.1.99 0000139,0004040,0005515,0005543,0005783,0005789,0005794,0006631,0008289,0009062,0016020,0016042,0016787,0016788,0017064,0031090,0042802,0045907,0047372,0052651,0098793,0098794,0098978,0150036 IC50=2.5nM P97612 12459591 600 ARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMT 1mt5 N 2.8 BS01 MAY N 1 M191 L192 S193 F194 S217 D237 I238 G239 S241 L372 A377 L380 F381 F432 I491 M155 L156 S157 F158 S181 D201 I202 G203 S205 L336 A341 L344 F345 F396 I455 K142 S217 S218 T236 I238 G239 G240 S241 F244 K106 S181 S182 T200 I202 G203 G204 S205 F208 3.1.1.-,3.5.1.99 0000139,0004040,0005515,0005543,0005783,0005789,0005794,0006631,0008289,0009062,0016020,0016042,0016787,0016788,0017064,0031090,0042802,0045907,0047372,0052651,0098793,0098794,0098978,0150036 IC50=2.5nM P97612 12459591 600 ARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMT 1mt5 O 2.8 BS01 MAY O 1 M191 L192 S193 S217 D237 I238 G239 S241 L372 A377 L380 F381 F432 T488 I491 W531 M155 L156 S157 S181 D201 I202 G203 S205 L336 A341 L344 F345 F396 T452 I455 W495 K142 S217 S218 T236 I238 G239 G240 S241 F244 K106 S181 S182 T200 I202 G203 G204 S205 F208 3.1.1.-,3.5.1.99 0000139,0004040,0005515,0005543,0005783,0005789,0005794,0006631,0008289,0009062,0016020,0016042,0016787,0016788,0017064,0031090,0042802,0045907,0047372,0052651,0098793,0098794,0098978,0150036 IC50=2.5nM P97612 12459591 600 ARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMT 1mt5 P 2.8 BS01 MAY P 1 M191 L192 S193 S217 D237 I238 G239 S241 L372 A377 F381 F432 T488 I491 W531 M155 L156 S157 S181 D201 I202 G203 S205 L336 A341 F345 F396 T452 I455 W495 K142 S217 S218 T236 I238 G239 G240 S241 F244 K106 S181 S182 T200 I202 G203 G204 S205 F208 3.1.1.-,3.5.1.99 0000139,0004040,0005515,0005543,0005783,0005789,0005794,0006631,0008289,0009062,0016020,0016042,0016787,0016788,0017064,0031090,0042802,0045907,0047372,0052651,0098793,0098794,0098978,0150036 IC50=2.5nM P97612 12459591 600 ARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMT 4pkb A 2.09 BS01 MAY A 1 G36 G37 G38 S77 T78 D215 G12 G13 G14 S53 T54 D191 3.1.1.- 0006629 -logKd/Ki=6.94, IC50=0.116uM Q8LPW4 25248161 401 LGEMVTVLSIDGGGIRGIIPATILEFLEGQLQEMDNNADARLADYFDVIGGTSTGGLLTAMISTPNENNRPFAAAKEIVPFYFEHGPQIFNPSGQILGPKYDGKYLMQVLQEKLGETRVHQALTEVVISSFDIKTNKPVIFTKSNLANSPELDAKMYDISYSTAAAPTYFPPHYFVTNTSNGDEYEFNLVDGAVATVADPALLSISVATRLAQKDPAFASIRSLNYKKMLLLSLGTGTTSEFDKTYTAKEAATWTAVHWMLVIQKMTDAASSYMTDYYLSTAFQALDSKNNYLRVQENALTGTTTEMDDASEANMELLVQVGENLLKKPVSEDNPETYEEALKRFAKLLSDRKKLRA 4x95 A 3.08 BS01 MAY A 1 G12 D13 S165 M166 K202 H359 G9 D10 S162 M163 K199 H356 2.3.1.-,3.1.1.32,3.1.1.4,3.1.1.5 0004622,0004623,0005515,0005543,0005576,0005615,0005654,0005764,0006629,0006631,0006644,0006650,0006651,0006658,0006672,0008270,0008374,0008970,0009062,0016020,0016042,0016411,0016746,0016787,0034638,0043231,0046338,0046470,0046471,0046872,0047499,0052739,0052740,0070062 Q8NCC3 25727495 407 HPPVVLVPGDLGNQLEAKLDKPTVVHYLCSKKTESYFTIWLNLELLLPVIIDCWIDNIRLVYNKTSRATQFPDGVDVRVPGFGKTFSLEFLDPSKSSVGSYFHTMVESLVGWGYTRGEDVRGAPYDWRRAPNENGPYFLALREMIEEMYQLYGGPVVLVAHSMGNMYTLYFLQRQPQAWKDKYIRAFVSLGAPWGGVAKTLRVLASGDNNRIPVIGPLKIREQQRSAVSTSWLLPYNYTWSPEKVFVQTPTINYTLRDYRKFFQDIGFEDGWLMRQDTEGLVEATMPPGVQLHCLYGTGVPTPDSFYYESFPDRDPKICFGDGDGTVNLKSALQCQAWQSRQEHQVLLQELPGSEHIEMLANATTLAYLKRVLLG 4x95 B 3.08 BS01 MAY B 1 G12 D13 L14 S165 M166 R214 H359 G10 D11 L12 S163 M164 R212 H357 2.3.1.-,3.1.1.32,3.1.1.4,3.1.1.5 0004622,0004623,0005515,0005543,0005576,0005615,0005654,0005764,0006629,0006631,0006644,0006650,0006651,0006658,0006672,0008270,0008374,0008970,0009062,0016020,0016042,0016411,0016746,0016787,0034638,0043231,0046338,0046470,0046471,0046872,0047499,0052739,0052740,0070062 Q8NCC3 25727495 407 RHPPVVLVPGDLGNQLEAKLDKPTVVHYLCSKKTESYFTIWLNLELLLPVIIDCWIDNIRLVYNKTSRATQFPDGVDVRVPGFGKTFSLEFLDPSKSSVGSYFHTMVESLVGWGYTRGEDVRGAPYDWRRAPNENGPYFLALREMIEEMYQLYGGPVVLVAHSMGNMYTLYFLQRQPQAWKDKYIRAFVSLGAPWGGVAKTLRVLASGDNNRIPVIGPLKIREQQRSAVSTSWLLPYNYTWSPEKVFVQTPTINYTLRDYRKFFQDIGFEDGWLMRQDTEGLVEATMPPGVQLHCLYGTGVPTPDSFYYESFPDRDPKICFGDGDGTVNLKSALQCQAWQSRQEHQVLLQELPGSEHIEMLANATTLAYLKRVLLGP 4x97 A 2.65 BS01 MAY A 1 G12 D13 W43 Y104 S165 M166 H359 I360 G10 D11 W41 Y102 S163 M164 H357 I358 2.3.1.-,3.1.1.32,3.1.1.4,3.1.1.5 0004622,0004623,0005515,0005543,0005576,0005615,0005654,0005764,0006629,0006631,0006644,0006650,0006651,0006658,0006672,0008270,0008374,0008970,0009062,0016020,0016042,0016411,0016746,0016787,0034638,0043231,0046338,0046470,0046471,0046872,0047499,0052739,0052740,0070062 Q8NCC3 25727495 405 RHPPVVLVPGDLGNQLEAKLDKPTVVHYLCSKKTESYFTIWLNLELLLPVIIDCWIDNIRLVYNKTSRATQFPDGVDVRVPGFGKTFSLEFLDPSKSSVGSYFHTMVESLVGWGYTRGEDVRGAPYDWRRAPNENGPYFLALREMIEEMYQLYGGPVVLVAHSMGNMYTLYFLQRQPQAWKDKYIRAFVSLGAPWGGVAKTLRVLASGDNNRIPVIGPLKIREQQRSAVSTSWLLPYNYTWSPEKVFVQTPTINYTLRDYRKFFQDIGFEDGWLMRQDTEGLVEATMPPGVQLHCLYGTGVPTPDSFYYESFPDRDPKICFGDGDGTVNLKSALQCQAWQSRQEHQVLLQELPGSEHIEMLANATTLAYLKRVLLGP 4x97 B 2.65 BS01 MAY B 1 G12 D13 S165 M166 H359 G10 D11 S163 M164 H357 2.3.1.-,3.1.1.32,3.1.1.4,3.1.1.5 0004622,0004623,0005515,0005543,0005576,0005615,0005654,0005764,0006629,0006631,0006644,0006650,0006651,0006658,0006672,0008270,0008374,0008970,0009062,0016020,0016042,0016411,0016746,0016787,0034638,0043231,0046338,0046470,0046471,0046872,0047499,0052739,0052740,0070062 Q8NCC3 25727495 405 RHPPVVLVPGDLGNQLEAKLDKPTVVHYLCSKKTESYFTIWLNLELLLPVIIDCWIDNIRLVYNKTSRATQFPDGVDVRVPGFGKTFSLEFLDPSKSSVGSYFHTMVESLVGWGYTRGEDVRGAPYDWRRAPNENGPYFLALREMIEEMYQLYGGPVVLVAHSMGNMYTLYFLQRQPQAWKDKYIRAFVSLGAPWGGVAKTLRVLASGDNNRIPVIGPLKIREQQRSAVSTSWLLPYNYTWSPEKVFVQTPTINYTLRDYRKFFQDIGFEDGWLMRQDTEGLVEATMPPGVQLHCLYGTGVPTPDSFYYESFPDRDPKICFGDGDGTVNLKSALQCQAWQSRQEHQVLLQELPGSEHIEMLANATTLAYLKRVLLGP 4x97 C 2.65 BS01 MAY C 1 G12 D13 W43 L94 Y104 S165 M166 H359 G9 D10 W40 L91 Y101 S162 M163 H356 2.3.1.-,3.1.1.32,3.1.1.4,3.1.1.5 0004622,0004623,0005515,0005543,0005576,0005615,0005654,0005764,0006629,0006631,0006644,0006650,0006651,0006658,0006672,0008270,0008374,0008970,0009062,0016020,0016042,0016411,0016746,0016787,0034638,0043231,0046338,0046470,0046471,0046872,0047499,0052739,0052740,0070062 Q8NCC3 25727495 405 HPPVVLVPGDLGNQLEAKLDKPTVVHYLCSKKTESYFTIWLNLELLLPVIIDCWIDNIRLVYNKTSRATQFPDGVDVRVPGFGKTFSLEFLDPSKSSVGSYFHTMVESLVGWGYTRGEDVRGAPYDWRRAPNENGPYFLALREMIEEMYQLYGGPVVLVAHSMGNMYTLYFLQRQPQAWKDKYIRAFVSLGAPWGGVAKTLRVLASGDNNRIPVIGPLKIREQQRSAVSTSWLLPYNYTWSPEKVFVQTPTINYTLRDYRKFFQDIGFEDGWLMRQDTEGLVEATMPPGVQLHCLYGTGVPTPDSFYYESFPDRDPKICFGDGDGTVNLKSALQCQAWQSRQEHQVLLQELPGSEHIEMLANATTLAYLKRVLLGP 4x97 D 2.65 BS01 MAY D 1 G12 D13 S165 M166 H359 G9 D10 S162 M163 H356 2.3.1.-,3.1.1.32,3.1.1.4,3.1.1.5 0004622,0004623,0005515,0005543,0005576,0005615,0005654,0005764,0006629,0006631,0006644,0006650,0006651,0006658,0006672,0008270,0008374,0008970,0009062,0016020,0016042,0016411,0016746,0016787,0034638,0043231,0046338,0046470,0046471,0046872,0047499,0052739,0052740,0070062 Q8NCC3 25727495 405 HPPVVLVPGDLGNQLEAKLDKPTVVHYLCSKKTESYFTIWLNLELLLPVIIDCWIDNIRLVYNKTSRATQFPDGVDVRVPGFGKTFSLEFLDPSKSSVGSYFHTMVESLVGWGYTRGEDVRGAPYDWRRAPNENGPYFLALREMIEEMYQLYGGPVVLVAHSMGNMYTLYFLQRQPQAWKDKYIRAFVSLGAPWGGVAKTLRVLASGDNNRIPVIGPLKIREQQRSAVSTSWLLPYNYTWSPEKVFVQTPTINYTLRDYRKFFQDIGFEDGWLMRQDTEGLVEATMPPGVQLHCLYGTGVPTPDSFYYESFPDRDPKICFGDGDGTVNLKSALQCQAWQSRQEHQVLLQELPGSEHIEMLANATTLAYLKRVLLGP