2vtp A 2.15 BS01 LZ9 A 1 I10 V18 A31 E81 F82 L83 H84 D86 L134 A144 D145 I10 V18 A31 E73 F74 L75 H76 D78 L126 A136 D137 D127 K129 Q131 N132 D145 T165 D119 K121 Q123 N124 D137 T148 2.7.11.22 0000082,0000086,0000122,0000287,0000307,0000781,0000793,0000805,0000806,0001673,0004672,0004674,0004693,0005515,0005524,0005634,0005635,0005654,0005667,0005737,0005768,0005813,0005829,0005856,0006260,0006281,0006338,0006351,0006468,0006813,0007099,0007165,0007265,0007346,0008284,0010389,0010468,0015030,0016301,0016310,0018105,0019904,0030332,0031453,0031571,0032298,0035173,0043247,0043687,0045740,0045893,0046872,0051298,0051301,0051321,0071732,0090398,0097123,0097124,0097134,0097135,0097472,0106310,1905784 ic50=0.003uM -logKd/Ki=8.52, IC50=3nM IC50=3.0nM P24941 18656911 1299 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 4y72 A 2.3 BS01 LZ9 A 1 I10 Y15 V18 A31 K33 E81 F82 L83 S84 K89 L135 D146 I13 Y18 V21 A34 K36 E84 F85 L86 S87 K92 L138 D149 D128 K130 Q132 N133 D146 V159 T166 D131 K133 Q135 N136 D149 V162 T169 2.7.11.22,2.7.11.23 0000082,0000086,0000226,0000307,0000781,0001618,0003682,0004672,0004674,0004693,0005515,0005524,0005634,0005654,0005737,0005739,0005759,0005789,0005813,0005819,0005829,0005856,0005876,0006260,0006281,0006338,0006357,0006468,0006915,0006974,0007077,0007095,0007098,0007344,0008353,0009410,0009636,0010628,0010629,0010971,0014038,0014070,0014075,0014823,0016020,0016301,0016310,0016477,0016579,0018105,0018107,0030261,0030332,0030496,0030544,0030855,0031100,0034501,0035173,0042307,0042542,0042752,0043066,0044772,0045471,0045740,0045931,0045995,0046686,0046688,0046718,0048144,0048511,0048678,0051301,0055015,0060045,0062033,0065003,0070062,0070301,0070371,0071407,0072686,0090166,0097121,0097122,0097125,0097472,0106310,1900182,1902423,1902850,1905448 ic50=10nM IC50=10.0nM P06493 25864384 301 LGSMEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 5hq0 A 2.3 BS01 LZ9 A 1 I10 Y15 V18 A31 K33 E81 F82 L83 S84 K89 L135 D146 I13 Y18 V21 A34 K36 E84 F85 L86 S87 K92 L138 D149 D128 K130 Q132 N133 D146 V159 T166 D131 K133 Q135 N136 D149 V162 T169 2.7.11.22,2.7.11.23 0000082,0000086,0000226,0000307,0000781,0001618,0003682,0004672,0004674,0004693,0005515,0005524,0005634,0005654,0005737,0005739,0005759,0005789,0005813,0005819,0005829,0005856,0005876,0006260,0006281,0006338,0006357,0006468,0006915,0006974,0007077,0007095,0007098,0007344,0008353,0009410,0009636,0010628,0010629,0010971,0014038,0014070,0014075,0014823,0016020,0016301,0016310,0016477,0016579,0018105,0018107,0030261,0030332,0030496,0030544,0030855,0031100,0034501,0035173,0042307,0042542,0042752,0043066,0044772,0045471,0045740,0045931,0045995,0046686,0046688,0046718,0048144,0048511,0048678,0051301,0055015,0060045,0062033,0065003,0070062,0070301,0070371,0071407,0072686,0090166,0097121,0097122,0097125,0097472,0106310,1900182,1902423,1902850,1905448 ic50=10nM IC50=10.0nM P06493 25864384 301 LGSMEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND