3csh A 1.55 BS01 LZ6 A 1 F8 P9 V10 R13 W38 K44 Q51 L52 Q64 S65 G205 F8 P9 V10 R13 W38 K44 Q51 L52 Q64 S65 G205 Y7 R13 Y7 R13 2.5.1.18 0000302,0002674,0004364,0004602,0005504,0005515,0005576,0005615,0005634,0005737,0005739,0005829,0006469,0006629,0006693,0006749,0006805,0007417,0008432,0009890,0010804,0016740,0019207,0031982,0032691,0032720,0032872,0032873,0032930,0034774,0035726,0035730,0035731,0035732,0043066,0043124,0043407,0043409,0043508,0043651,0048147,0051122,0051771,0070026,0070062,0070372,0070373,0070664,0071222,0071638,0097057,0098869,1901687,1904813,2001237 P09211 18511072 212 PPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGDLTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYVKALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAYVGRLSARPKLKAFLASPEYVNLPINGNGKQ 3csh B 1.55 BS02 LZ6 B 1 F8 P9 V10 R13 V35 W38 K44 Q51 L52 Q64 S65 G205 F8 P9 V10 R13 V35 W38 K44 Q51 L52 Q64 S65 G205 Y7 R13 Y7 R13 2.5.1.18 0000302,0002674,0004364,0004602,0005504,0005515,0005576,0005615,0005634,0005737,0005739,0005829,0006469,0006629,0006693,0006749,0006805,0007417,0008432,0009890,0010804,0016740,0019207,0031982,0032691,0032720,0032872,0032873,0032930,0034774,0035726,0035730,0035731,0035732,0043066,0043124,0043407,0043409,0043508,0043651,0048147,0051122,0051771,0070026,0070062,0070372,0070373,0070664,0071222,0071638,0097057,0098869,1901687,1904813,2001237 P09211 18511072 214 PPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGDLTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYVKALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAYVGRLSARPKLKAFLASPEYVNLPINGNGKQ 3csi A 1.9 BS01 LZ6 A 1 F8 P9 V10 R13 V35 W38 K44 Q51 L52 Q64 S65 Y108 G205 F8 P9 V10 R13 V35 W38 K44 Q51 L52 Q64 S65 Y108 G205 Y7 R13 Y7 R13 2.5.1.18 0000302,0002674,0004364,0004602,0005504,0005515,0005576,0005615,0005634,0005737,0005739,0005829,0006469,0006629,0006693,0006749,0006805,0007417,0008432,0009890,0010804,0016740,0019207,0031982,0032691,0032720,0032872,0032873,0032930,0034774,0035726,0035730,0035731,0035732,0043066,0043124,0043407,0043409,0043508,0043651,0048147,0051122,0051771,0070026,0070062,0070372,0070373,0070664,0071222,0071638,0097057,0098869,1901687,1904813,2001237 P09211 18511072 212 PPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGDLTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYVSLIYTNYEVGKDDYVKALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAYVGRLSARPKLKAFLASPEYVNLPINGNGKQ 3csi B 1.9 BS03 LZ6 B 1 F8 R13 V35 W38 K44 Q51 L52 Q64 S65 G205 F8 R13 V35 W38 K44 Q51 L52 Q64 S65 G205 Y7 R13 Y7 R13 2.5.1.18 0000302,0002674,0004364,0004602,0005504,0005515,0005576,0005615,0005634,0005737,0005739,0005829,0006469,0006629,0006693,0006749,0006805,0007417,0008432,0009890,0010804,0016740,0019207,0031982,0032691,0032720,0032872,0032873,0032930,0034774,0035726,0035730,0035731,0035732,0043066,0043124,0043407,0043409,0043508,0043651,0048147,0051122,0051771,0070026,0070062,0070372,0070373,0070664,0071222,0071638,0097057,0098869,1901687,1904813,2001237 P09211 18511072 216 PPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGDLTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYVSLIYTNYEVGKDDYVKALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAYVGRLSARPKLKAFLASPEYVNLPINGNGKQ 3csi C 1.9 BS01 LZ6 C 1 F8 P9 V10 R13 T34 V35 W38 K44 Q51 L52 Q64 S65 Y108 G205 F8 P9 V10 R13 T34 V35 W38 K44 Q51 L52 Q64 S65 Y108 G205 Y7 R13 Y7 R13 2.5.1.18 0000302,0002674,0004364,0004602,0005504,0005515,0005576,0005615,0005634,0005737,0005739,0005829,0006469,0006629,0006693,0006749,0006805,0007417,0008432,0009890,0010804,0016740,0019207,0031982,0032691,0032720,0032872,0032873,0032930,0034774,0035726,0035730,0035731,0035732,0043066,0043124,0043407,0043409,0043508,0043651,0048147,0051122,0051771,0070026,0070062,0070372,0070373,0070664,0071222,0071638,0097057,0098869,1901687,1904813,2001237 P09211 18511072 211 PPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGDLTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYVSLIYTNYEVGKDDYVKALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAYVGRLSARPKLKAFLASPEYVNLPINGNGKQ 3csi D 1.9 BS02 LZ6 D 1 F8 R13 W38 Q51 L52 Q64 S65 G205 F8 R13 W38 Q51 L52 Q64 S65 G205 Y7 R13 Y7 R13 2.5.1.18 0000302,0002674,0004364,0004602,0005504,0005515,0005576,0005615,0005634,0005737,0005739,0005829,0006469,0006629,0006693,0006749,0006805,0007417,0008432,0009890,0010804,0016740,0019207,0031982,0032691,0032720,0032872,0032873,0032930,0034774,0035726,0035730,0035731,0035732,0043066,0043124,0043407,0043409,0043508,0043651,0048147,0051122,0051771,0070026,0070062,0070372,0070373,0070664,0071222,0071638,0097057,0098869,1901687,1904813,2001237 P09211 18511072 214 PPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGDLTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYVSLIYTNYEVGKDDYVKALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAYVGRLSARPKLKAFLASPEYVNLPINGNGKQ 4hj2 A 2.1 BS01 LZ6 A 1 Y9 R45 Q54 V55 Q67 T68 L107 P110 M208 F220 Y6 R42 Q51 V52 Q64 T65 L104 P107 M205 F217 Y9 R15 R20 Y6 R12 R17 1.11.1.-,2.5.1.18,5.3.3.- 0004364,0004601,0004602,0004769,0005504,0005515,0005737,0005829,0006629,0006693,0006749,0006805,0016740,0016853,0030855,0043651,0070062,0098869,1901687 -logKd/Ki=2.53, Kd=2.95mM P08263 23460799 301 KPKLHYFNARGRMESTRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLMFQQVPMVEIDGMKLVQTRAILNYIASKYNLYGKDIKERALIDMYIEGIADLGEMILLLPVCPPEEKDAKLALIKEKIKNRYFPAFEKVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDSSLISSFPLLKALKTRISNLPTVKKFLQPGSPRKPPMDEKSLEEARKIF 4hj2 A 2.1 BS02 LZ6 B 1 D101 R131 D98 R128 Y9 R15 R20 Y6 R12 R17 1.11.1.-,2.5.1.18,5.3.3.- 0004364,0004601,0004602,0004769,0005504,0005515,0005737,0005829,0006629,0006693,0006749,0006805,0016740,0016853,0030855,0043651,0070062,0098869,1901687 -logKd/Ki=2.53, Kd=2.95mM P08263 23460799 301 KPKLHYFNARGRMESTRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLMFQQVPMVEIDGMKLVQTRAILNYIASKYNLYGKDIKERALIDMYIEGIADLGEMILLLPVCPPEEKDAKLALIKEKIKNRYFPAFEKVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDSSLISSFPLLKALKTRISNLPTVKKFLQPGSPRKPPMDEKSLEEARKIF 4hj2 B 2.1 BS01 LZ6 A 1 D101 R131 D98 R124 Y9 R15 R20 Y6 R12 R17 1.11.1.-,2.5.1.18,5.3.3.- 0004364,0004601,0004602,0004769,0005504,0005515,0005737,0005829,0006629,0006693,0006749,0006805,0016740,0016853,0030855,0043651,0070062,0098869,1901687 -logKd/Ki=2.53, Kd=2.95mM P08263 23460799 301 KPKLHYFNARGRMESTRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLMFQQVPMVEIDGMKLVQTRAILNYIASKYNLYGKDIKERALIDMYIEGIADLGEMILLLPVEKDAKLALIKEKIKNRYFPAFEKVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDSSLISSFPLLKALKTRISNLPTVKKFLQPGSPRKPPMDEKSLEEARKIF 4hj2 B 2.1 BS02 LZ6 B 1 Y9 R45 Q54 V55 Q67 T68 L107 P110 M208 F220 Y6 R42 Q51 V52 Q64 T65 L104 P107 M201 F213 Y9 R15 R20 Y6 R12 R17 1.11.1.-,2.5.1.18,5.3.3.- 0004364,0004601,0004602,0004769,0005504,0005515,0005737,0005829,0006629,0006693,0006749,0006805,0016740,0016853,0030855,0043651,0070062,0098869,1901687 -logKd/Ki=2.53, Kd=2.95mM P08263 23460799 301 KPKLHYFNARGRMESTRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLMFQQVPMVEIDGMKLVQTRAILNYIASKYNLYGKDIKERALIDMYIEGIADLGEMILLLPVEKDAKLALIKEKIKNRYFPAFEKVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDSSLISSFPLLKALKTRISNLPTVKKFLQPGSPRKPPMDEKSLEEARKIF