2vta A 2.0 BS01 LZ1 A 1 A31 F82 L83 L134 A31 F73 L74 L125 D127 K129 Q131 N132 D145 T165 D118 K120 Q122 N123 D136 T145 2.7.11.22 0000082,0000086,0000122,0000287,0000307,0000781,0000793,0000805,0000806,0001673,0004672,0004674,0004693,0005515,0005524,0005634,0005635,0005654,0005667,0005737,0005768,0005813,0005829,0005856,0006260,0006281,0006338,0006351,0006468,0006813,0007099,0007165,0007265,0007346,0008284,0010389,0010468,0015030,0016301,0016310,0018105,0019904,0030332,0031453,0031571,0032298,0035173,0043247,0043687,0045740,0045893,0046872,0051298,0051301,0051321,0071732,0090398,0097123,0097124,0097134,0097135,0097472,0106310,1905784 ic50=185uM -logKd/Ki=3.73, IC50=185uM IC50=185000nM P24941 18656911 1301 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL 3e6i A 2.2 BS02 LZ1 A 1 F298 A299 T303 F478 F267 A268 T272 F447 T303 F430 C437 T272 F399 C406 1.14.13.n7,1.14.14.1 0001676,0002933,0004497,0005506,0005737,0005739,0005743,0005783,0005789,0006631,0006805,0008202,0008392,0009617,0016098,0016491,0016705,0016709,0016712,0018601,0018885,0018910,0018960,0019373,0019825,0019899,0020037,0030544,0042197,0042759,0043231,0046872,0051879,0070330,0120319 P05181 18818195 501 KLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPRS 3e6i B 2.2 BS02 LZ1 B 1 F298 A299 T303 F478 F266 A267 T271 F446 T303 F430 C437 T271 F398 C405 1.14.13.n7,1.14.14.1 0001676,0002933,0004497,0005506,0005737,0005739,0005743,0005783,0005789,0006631,0006805,0008202,0008392,0009617,0016098,0016491,0016705,0016709,0016712,0018601,0018885,0018910,0018960,0019373,0019825,0019899,0020037,0030544,0042197,0042759,0043231,0046872,0051879,0070330,0120319 P05181 18818195 501 KLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPRS 4b2i A 1.3 BS01 LZ1 A 1 M169 I171 A201 A203 Q217 A218 M62 I64 A94 A96 Q110 A111 ? 0003677,0003684,0005524,0006259,0006281,0006310,0008094,0016887,0140664 Kd=1mM -logKd/Ki=3.00, Kd=1.0mM Kd=1000000nM O74036 23344974 1351 ATIGRISTGSKSLDKLLGGGIETQAITEVFGEFGSGKTQLAHTLAVMVQLPPEEGGLNGSVMWIDTENTFRPERIREIAQNRGLDPDEVLKHIAYARAFNSNHQMLLVQQAEDMIKELLNTDRPVKLLIVDSLTSHFRSEYIGRGALAERQQKLAKHLADLHRLANLYDIAVFVTNQVSATLRVYLRKGKGGKRIARLIDAPHLPEGEAVFSITEKGIED 5lk9 A 1.12 BS02 LZ1 A 1 F21 F35 T56 V59 F21 F35 T56 V59 ? 0004601,0005344,0015671,0019825,0020037,0046872,0098869 Q9NAV7 205 GFKQDIATLRGDLRTYAQDIFLAFLNKYPDEKRNFKNYVGKSDQELKSMAKFGDHTEKVFNLMMEVADRATDCVPLASDASTLVQMKQHSGLTTGNFEKLFVALVEYMRASGQSFDSQSWDRFGKNLVSALSSAGMK 5lk9 B 1.12 BS02 LZ1 B 1 F21 F35 T56 V59 F21 F35 T56 V59 ? 0004601,0005344,0015671,0019825,0020037,0046872,0098869 Q9NAV7 305 GFKQDIATLRGDLRTYAQDIFLAFLNKYPDEKRNFKNYVGKSDQELKSMAKFGDHTEKVFNLMMEVADRATDCVPLASDASTLVQMKQHSGLTTGNFEKLFVALVEYMRASGQSFDSQSWDRFGKNLVSALSSAGMK 5qur A 1.247 BS01 LZ1 A 1 M169 W170 I171 A201 A203 M62 W63 I64 A94 A96 ? 0003677,0003684,0005524,0006259,0006281,0006310,0008094,0016887,0140664 Kd=1000000nM O74036 401 ATIGRISTGSKSLDKLLGGGIETQAITEVFGEFGSGKTQLAHTLAVMVQLPPEEGGLNGSVMWIDTENTFRPERIREIAQNRGLDPDEVLKHIAYARAFNSNHQMLLVQQAEDMIKELLNTDRPVKLLIVDSLTSHFRSEYIGRGALAERQQKLAKHLADLHRLANLYDIAVFVTNQVILAHSATLRVYLRKGKGGKRIARLIDGEAVFSITEKGIED 5qus A 1.247 BS01 LZ1 A 1 M169 I171 A201 A203 M62 I64 A94 A96 ? 0003677,0003684,0005524,0006259,0006281,0006310,0008094,0016887,0140664 Kd=1000000nM O74036 401 ATIGRISTGSKSLDKLLGGGIETQAITEVFGEFGSGKTQLAHTLAVMVQLPPEEGGLNGSVMWIDTENTFRPERIREIAQNRGLDPDEVLKHIAYARAFNSNHQMLLVQQAEDMIKELLNTDRPVKLLIVDSLTSHFRSEYIGRGALAERQQKLAKHLADLHRLANLYDIAVFVTNQVQILAHSATLRVYLRKGKGGKRIARLIDGEAVFSITEKGIED 5qut A 1.248 BS01 LZ1 A 1 M169 I171 A201 A203 M62 I64 A94 A96 ? 0003677,0003684,0005524,0006259,0006281,0006310,0008094,0016887,0140664 Kd=1000000nM O74036 401 ATIGRISTGSKSLDKLLGGGIETQAITEVFGEFGSGKTQLAHTLAVMVQLPPEEGGLNGSVMWIDTENTFRPERIREIAQNRGLDPDEVLKHIAYARAFNSNHQMLLVQQAEDMIKELLNTDRPVKLLIVDSLTSHFRSEYIGRGALAERQQKLAKHLADLHRLANLYDIAVFVTNQVQILAHSATLRVYLRKGKGGKRIARLIDGEAVFSITEKGIED 7h97 A 1.54 BS01 LZ1 A 1 M9 D10 R144 M12 D13 R147 2.1.1.-,2.7.7.-,2.7.7.19,2.7.7.48,3.1.3.84,3.4.22.-,3.6.1.15,3.6.1.74,3.6.4.13 Q8JUX6 211 GAMAPSYRVKRMDIAKNDEECVVNAANPRGLPGDGVCKAVYKKWPESFKNSATPVGTAKTVMCGTYPVIHAVGPNFSNYTESEGDRELAAAYREVAKEVTRLGVNSVAIPLLSTGVYSGGKDRLTQSLNHLFTAMDSTDADVVIYCRDKEWEKKISEAIQMRT 7h97 D 1.54 BS01 LZ1 D 1 D10 R144 D9 R143 2.1.1.-,2.7.7.-,2.7.7.19,2.7.7.48,3.1.3.84,3.4.22.-,3.6.1.15,3.6.1.74,3.6.4.13 Q8JUX6 207 PSYRVKRMDIAKNDEECVVNAANPRGLPGDGVCKAVYKKWPESFKNSATPVGTAKTVMCGTYPVIHAVGPNFSNYTESEGDRELAAAYREVAKEVTRLGVNSVAIPLLSTGVYSGGKDRLTQSLNHLFTAMDSTDADVVIYCRDKEWEKKISEAIQMRT 7o6r A 2.0 BS01 LZ1 A 1 G484 L486 I503 N505 R509 G469 L471 I488 N490 R494 3.6.4.10 0005524,0140662 P19120 38317495 902 GPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTVFDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVSSMVLTKMKEIAEAYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNVLIFDLGGGTFDVSILTIAAGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAEKYKAEDEKQRDKVSSKNSLESYAFNMKA